CN1166599A - Agitator of automatic analyzer - Google Patents

Agitator of automatic analyzer Download PDF

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Publication number
CN1166599A
CN1166599A CN 96107568 CN96107568A CN1166599A CN 1166599 A CN1166599 A CN 1166599A CN 96107568 CN96107568 CN 96107568 CN 96107568 A CN96107568 A CN 96107568A CN 1166599 A CN1166599 A CN 1166599A
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China
Prior art keywords
stirrer
stirring parts
automatic analyzer
reaction vessel
mentioned
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CN 96107568
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Chinese (zh)
Inventor
藤冈秀彦
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Mitsubishi Corp
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Mitsubishi Corp
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Priority to CN 96107568 priority Critical patent/CN1166599A/en
Publication of CN1166599A publication Critical patent/CN1166599A/en
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Abstract

An agitator does not require the use of washing water and hence can reduce the cost of analyzing operation. The agitator of an automatic analyzer for automatically feeding a specimen and a reagent into a reaction container, stirring them in the container and carrying out an optical analysis of the specimen is characterized in that it comprises a stirring member staying in the reaction container until an analyzing operation is over.

Description

The stirrer of automatic analyzer
The present invention relates to a kind of stirrer of automatic analyzer, described automatic analyzer can automatically add sample and reagent in reaction vessel, and in container, stir, then sample is carried out optical analysis, the automatic analyzer that has stirrer of the present invention is applicable to occasions such as biochemical analysis, immunoassay and physicochemical analysis.
In the process of the water of chemical analysis blood, urine or environmental pollution, in order to sieve a large amount of samples, just must stir effectively sample and reagent by the multiple inspection project, their are fully mixed each other.
Japanese Utility Model No.1-31305 announced a kind of general mixer of automatic analyzer, and this stirrer contains a rotating stirring rod and an agitating plate that is fixed on this stirring rod front end.When each stirring operation, stirring rod is inserted in the reaction vessel, stir finish after, just stirring rod is taken out from container so that wash, preparation is used next time again.
Japanese Utility Model No.62-299961 and 63-14904 announced other the stirrer that has stirring rod, when using this class stirrer, also be that stirring rod is inserted in the reaction vessel that fills sample and reagent solution, and according to axial rotation, centrifugal rotation, vertical movement, intermittent exercise and other stirring modes stir.Operation is just taken out stirring rod, and is washed after stirring and finishing, in order to using next time again.
When adopting described any stirrer of above-mentioned Japanese Utility Model No.1-31305,62-29961 and 63-14904, stirring rod all will be washed, and will consume a large amount of slurries in each operation.This washings also must be highly purified, can only could obtain by distillation or double ion exchange process, and this has just improved the cost of analysis operation.
In addition, when washed stirring rod is inserted in the reaction vessel, some water can be brought in the container inevitably, this has just produced the problem of cross pollution, and, reduced the degree of accuracy of test findings owing to the volume that has changed reaction solution.
At last, above-mentioned any general mixer also must be equipped with and drive stirring rod and enter the pump device relevant with other with the mechanism of the mechanism that shifts out reaction vessel, wash agitation rod, sink, pumping washings, thereby the volume of stirrer is increased, and manufacturing cost increases.
Therefore, the problems referred to above and other problems at existing stirrer an object of the present invention is to provide a kind of stirrer that does not need to use washings, therefore can reduce the cost of analysis operation.
Another object of the present invention provides a kind of like this stirrer, promptly, its stirring parts need not to send into and shift out reaction vessel, therefore do not exist because stirring parts is brought the cross-contamination issue that washings produce to the container into, do not have the problem that reduces the degree of accuracy of test findings owing to change reaction solution volume yet.Therefore, the automatic analyzer that has a this stirrer all is highly reliable for any analysis.
A further object of the present invention provides a kind of like this stirrer, and promptly it need not to be equipped with and drives stirring rod and enter the pump device relevant with other with the mechanism of the mechanism that shifts out container, wash agitation rod, sink, pumping washings.Therefore, this stirrer is a compact conformation, and manufacturing cost is also low.
According to the present invention, reach above-mentioned projects by the stirrer that a kind of automatic analyzer is provided, described automatic analyzer can add sample and reagent automatically in reaction vessel, and in container, stir, then sample is carried out optical analysis, above-mentioned stirrer is characterised in that it has a stirring parts, and this stirring parts placed reaction vessel always before analysis operation is finished.
In a most preferred embodiment, stirring parts placed reaction vessel always before reaction vessel is scrapped processing.In another most preferred embodiment, reaction vessel can automatically infeed and scrap.In another most preferred embodiment, stirring parts has the agitating plate that a profile roughly is complementary with the level cross-sectionn of container.In another most preferred embodiment, the agitating plate of stirring parts is provided with the through hole that can allow flow of liquid cross.In yet another embodiment, stirring parts is connected with driving mechanism by an elongated rod member.Preferably, stirring parts is connected with driving mechanism by a plate that extends by the direction of reaction vessel along light beam.Preferably, the stirring parts vertical cross-section that allows to analyze the zone that light beam passes through in reaction vessel is greater than the fair vertical cross-section of analyzing the zone that light beam passes through.Stirring parts preferably has spiral helicine profile.Stirring parts is a vertically disposed flat board preferably, and the zone that this flat board makes the analysis light beam pass through in reaction vessel is provided with several through holes.Preferably, when entering reaction vessel, stirring parts controls its temperature.The stirring operation of stirring parts is preferably undertaken by ultrasonic vibration.Preferably, stirring parts can be controlled stirring operation automatically according to the test event in the analysis cycle.
According to another aspect of the present invention, the stirrer that a kind of automatic analyzer is used has been proposed, described automatic analyzer can add sample and reagent automatically in reaction vessel, and in container, stir, then sample is carried out optical analysis, above-mentioned stirrer is characterised in that it contains a kind of dismountable stirring parts.
The stirrer of automatic analyzer of the present invention, its stirring parts is not washed and reuse, but with after scrapped, so stirrer always is to use new stirring parts.
Describe the present invention in detail below in conjunction with accompanying drawing, in the accompanying drawing:
Fig. 1 is the simple skeleton view of stirring parts of first embodiment of stirrer of the present invention;
Fig. 2 is the planimetric map that has the automatic analyzer of stirring parts embodiment illustrated in fig. 1;
Fig. 3 is the schematic perspective view of reaction vessel that has the stirring parts of Fig. 1 embodiment;
Fig. 4 is the diagrammatic cross-sectional view of the mechanism of vertical drive stirring parts embodiment illustrated in fig. 1;
Fig. 5 is the schematic perspective view of second embodiment of the stirring parts of stirrer of the present invention;
Fig. 6 is the schematic perspective view of the 3rd embodiment of the stirring parts of stirrer of the present invention;
Fig. 7 is the schematic perspective view of the 4th embodiment of the stirring parts of stirrer of the present invention;
Fig. 8 is the schematic perspective view of the 5th embodiment of the stirring parts of stirrer of the present invention;
Fig. 9 is the schematic perspective view of the 6th embodiment of the stirring parts of stirrer of the present invention;
Figure 10 is the schematic perspective view of the 7th embodiment of the stirring parts of stirrer of the present invention;
Figure 11 is the schematic perspective view of the 8th embodiment of the stirring parts of stirrer of the present invention;
Figure 12 is the schematic perspective view of the 9th embodiment of the stirring parts of stirrer of the present invention.
Description of drawings the present invention referring to expression most preferred embodiment of the present invention.
At first referring to Fig. 2, Fig. 2 shows the automatic analyzer of the stirrer that contains the first embodiment of the present invention briefly, and this automatic analyzer 1 contains reagent tray 4 and the reaction vessel pallet 6 that is positioned at automatic analyzer central authorities.In addition, also have an automatic sampler that is used for depositing automatically and supply with sample (nearside along analyser is arranged) 10, one be positioned at automatic sampler 10 next doors reaction vessel infeed/take out station 12 and a sub-ray spectrometer 14 that is positioned at automatic analyzer 1 distally.Be provided with the supervisory keyboard that has a plurality of key (not shown) 20 of the parameter of a job that is used for importing control automatic analyzer 1 in the behind of automatic analyzer 1,22, one of LCD that are used for showing ongoing analysis operation and other job statuses is used for printing the printer 24 of data that analysis operation obtains and one and is used for input system program and running parameter and record analysis and operates the floppy disk 26 of the data that obtain.
Automatic sampler 10 has a cycloconveyor belt 100, is mounted with 50 test tubes 102 that post corresponding bar code on this conveying belt 100, and along an orbital motion that is roughly rectangle.In the track inboard of cycloconveyor belt 100 one first stripe shape code reader 104 is arranged, be used for reading bar code by on the test tube 102 in precalculated position on the track.
Inner region 150 along reagent tray 4 is arranged 24 reagent bottles 154 that post corresponding bar code, also arranges the same number of reagent bottle 154 that posts corresponding bar code along its outskirt 152, and reagent tray 4 rotates along clockwise direction.The outside, neighboring at reagent tray 4 has one to carry bottle mechanical arm 161, be used for mentioning the reagent bottle 154 in the outskirt 152, so that the corresponding reagent bottle 154 in the visible inner region 150, and can read its bar code by getting bottleneck 155, outside the periphery of reagent tray 4, also have second a stripe shape code reader 156 that is used for reading by the bar code on the reagent bottle of getting bottleneck 155.In addition, outside the periphery outside reagent tray 4, also have one the first reagent aspirating pipe 162 and the second reagent aspirating pipe 160, the former is used for inhaling the reagent in the reagent bottle 154 that moves outskirt 152, and the latter is used for inhaling the reagent in the reagent bottle 154 that moves inner region 150.In the outside, the neighboring of reagent tray 4, also have the first and second suction pipe head sinks 170 and 172, they are entreated among being separately positioned on the track that sucks the suction pipe head 166 of centre and the second reagent aspirating pipe 160 among 164 the track of the first reagent aspirating pipe 162.
Circumferential periphery along reaction vessel pallet 6 is loaded with a reaction vessel 202, this container has dismountable stirring parts 200 of a first embodiment of the invention, reaction vessel pallet 6 rotates in the counterclockwise direction, the outside, neighboring at reaction vessel pallet 6, the station 12 of a supply/taking-up container, sub-ray spectrometer 14 and first, second assembly 210,212 are arranged, and the stirring parts 200 that described assembly 210,212 is used for vertically will delivering on the relevant position pushes in the reaction vessel 202.
The supply of above-mentioned reaction vessel/taking-up station 12 is designed to have the reaction vessel box of 10 stackings, each container contains again and is 100 reaction vessels 202 of total that 10 row * 10 row forms are arranged, so it can in turn supply to the reaction vessel 202 that has stirring parts 200 on the reaction vessel pallet 6, and after each analysis operation is finished, regain reaction vessel 202 successively so that carry out waste disposal.
As shown in Figure 3, the shape of each reaction vessel 202 all is the cuboid of upper opening, and they have a pair of bottom to be provided with the opposed sidewall of corresponding light hole 250.Can find out that from Fig. 1 and 3 stirring parts 200 (being to place in the container 202 in Fig. 3) also has a cuboid main body 252, the base plate 254 of this main body 252 is hung by 4 poles 256 and a pair of button card 260 that is arranged on main body 252 tops opposed to each other.
As shown in Figure 4, the mixing arm plate 304 that the guide rail (not shown) of a level meter that is used for fixing assembly and one can vertical moving is contained in the mechanism's mechanism of second assembly 212 of stirring parts (or vertically drive) that vertically drives first assembly 210 of stirring parts, and this mixing arm plate 304 mobile is by means of realizing by and the vertical drive screw 300 that counterclockwise rotates and the work of meshing and being fixed on the nut 302 on the mixing arm plate 304 with its clockwise.A motor 306 and a pair of slide block 308 and 310 are housed on mixing arm plate 304, this slide block 308 and 310 has respectively with slide block drive screw 320 and is meshed but reverse each other internal thread, and above-mentioned slide block drive screw 320 is driven by conical gear 322 by motor 306. Slide block 308 and 310 bottom are respectively equipped with the retained part 330 that engages with the button card 260 of corresponding stirring parts 200.Therefore, when motor 306 work, it just drives slide block drive screw 320 along slide block 308 and 310 directions close to each other or that leave are rotated, thereby can be as required clamp or unclamp stirring parts 200 by the retaining part 330 of slide block 308 and 310, when vertical drive screw 300 is worked, can make mixing arm plate 304 and relevant slide block 308 and 310 vertical moving.The stirring movement and the stirring rate thereof according to track of stirring parts 200 are decided according to Interventions Requested, and are controlled automatically by a control gear (not shown).
As shown in Figure 2, sub-ray spectrometer 14 is a kind of very common spectroscopy instruments of using diffraction grating, from the light beam of light source 350 by being installed in the light hole 250 of reaction vessel 202 bottoms on the reaction vessel pallet 6, and connect electro-optical device 352 receive before by diffraction grating 360 diffraction.
The following describes other embodiment of stirring parts.
The stirring parts 400 of second embodiment shown in Fig. 5 contains the main body 402 of a cuboid, and this main body 402 is provided with slit 403, and its base plate 404 is hung by 4 poles 406 and a pair of button card 410 in main body 402 top opposite disposed.In this embodiment, stirring parts 400 also is a vertical moving and carry out stirring operation.
The stirring parts 450 of the third embodiment of the invention shown in Fig. 6 contains the main body 452 of a cuboid, this main body 452 is provided with a slit 453, its base plate 454 is by a pair of support plate 456 and a pair of opposed button card 460 hangs at main body 452 tops, in this embodiment, stirring parts 450 also is a vertical moving and stirring.
Fig. 7 illustrates the stirrer 500 of the 4th embodiment, and this stirring parts 500 has a columnar member 502, is respectively equipped with at the bottom of columnar member 502 and middle part and stirs boss 504 and 506, and in this embodiment, stirring parts 500 also is a vertical moving and stirring.
Fig. 8 illustrates the stirring parts 550 of the 5th embodiment, and this stirring parts 550 has a columnar member 552, is respectively equipped with agitating auger blade 554 and 556 in its bottom and middle part.In this embodiment, stirring parts 550 is rotated and is stirred, and the light beam of sub-ray spectrometer 14 is by the space between the agitating auger blade 554 and 556.Screw blade 554 and 556 screw thread trend are reciprocal, so when stirring parts 550 was rotated, the sample at upper and lower positions just was forced to flow to the space between agitating auger blade 554 and 556 in the reaction vessel 202.
Fig. 9 illustrates the stirring parts 600 of the 6th embodiment, it has a main body 602 that hangs the cuboid of agitating plate 604, on above-mentioned agitating plate 604, be provided with big through hole 606 and several little through holes 608 that can allow light beam pass through, one make-up card 460 is set on the top of main body 602 opposed to each other, in this embodiment, stirring parts 600 is flatly to move back and forth and stir along the direction perpendicular to agitating plate 604.
Figure 10 illustrates the stirring parts 650 of the 7th embodiment, it has a main body 652 that hangs the cuboid of agitating plate 654, main body 652 at the cuboid of above-mentioned agitating plate 654, a plurality of small through hole 658 are arranged on above-mentioned agitating plate 654, a pair of opposed buckle 660 is arranged at the top of main body 652, in this embodiment, stirring parts 650 is flatly to move back and forth and stir along the direction perpendicular to agitating plate 654.Light beam B from sub-ray spectrometer 14 passes through along the surface of agitating plate 654.
Figure 11 illustrates the stirring parts 700 of the 8th embodiment, and it has a cylinder-shaped body 702 that hangs agitating plate 704, and there is a columniform chuck 706 upper end of this main body 702.In this embodiment, stirring parts 700 is to vibrate by means of ultrasound wave.Stir around its vertical axis rotation again simultaneously.When agitating plate 704 stopped operating, the light beam that is parallel to come comfortable sub-ray spectrometer 14 was to carry out spectrophotometry.
Figure 12 illustrates the stirring parts 750 of the 9th embodiment, and it has a cylinder-shaped body 752 that hangs columnar member 756, and a screw blade 754 is arranged in the bottom of columnar member 756.In this embodiment, stirring parts 750 is carried out stirring operation around its vertical axis rotation.
In another embodiment of the present invention, the solution in the reaction vessel is stirred by a dismountable stirring parts, and after stirring operation is finished, and stirring parts is taken out and scraps it.
In another embodiment of the present invention, stirring parts is not inserted in the reaction vessel in advance, but just inserts in the container when stirring.
In another embodiment of the present invention, sample in the reaction vessel and reagent are through after stirring, and the solution that stirred does not directly carry out spectrophotometry, but moves on in the photometry pond (for example flow cell), and then carry out the spectrophotometry operation.
As mentioned above, stirrer of the present invention does not need to use washings, therefore can reduce the analysis operation cost.
In addition, the stirring parts of stirrer of the present invention does not need to send into and shift out reaction vessel, therefore, do not exist, do not have the problem that causes the precision reduction of test result owing to the volume change of reaction solution yet owing to washings therewith enter the cross-contamination issue that container causes.Therefore, any analysis that has an automatic analyzer of this stirrer all is highly reliable.
Moreover stirrer of the present invention does not need to be used for driving the mechanism that puddler entered or shifted out reaction vessel, does not need the mechanism and sink, the pump that transports washings and other relevant devices of wash agitation bar yet.Therefore, this agitator structure compactness, low cost of manufacture.
Especially, any stirring parts of the first, second, third, the 6th and the 7th above-mentioned embodiment can be come stirred sample and reagent by means of the nozzle of minute feeding sample and reagent, thus can be when sending into reagent or after sending into reagent immediately the whole solution to sample and reagent stir.Therefore, the stirrer that has this class stirring parts can be effectively applied to the occasion that initial reaction takes place fast for sample and reagent, for example occasion of latex immunity nephelometric analysis.

Claims (14)

1. can supply with sample and reagent stir the automatic analyzer of the optical analysis of carrying out sample then in reaction vessel and in container stirrer automatically for one kind,
It is characterized in that above-mentioned stirrer contains a stirring parts, this stirring parts placed reaction vessel always before analysis operation is finished.
2. according to the stirrer of the automatic analyzer of claim 1, it is characterized in that above-mentioned stirring parts placed reactor always before reaction vessel is scrapped.
3. according to the stirrer of the automatic analyzer of claim 1, it is characterized in that above-mentioned reaction vessel automatically infeeds and takes out and scrap.
4. according to the stirrer of the automatic analyzer of claim 1, it is characterized in that above-mentioned stirring parts has an agitating plate, the shape of this plate and the level cross-sectionn of reaction vessel are complementary basically.
5. according to the stirrer of the automatic analyzer of claim 4, it is characterized in that the agitating plate of above-mentioned stirring parts is provided with several through holes that can allow liquid pass through.
6. according to the stirrer of the automatic analyzer of claim 4, it is characterized in that above-mentioned stirring parts is connected with driving mechanism by an elongated rod member.
7. according to the stirrer of the automatic analyzer of claim 4, it is characterized in that above-mentioned stirring parts is connected with driving mechanism by a plate that extends by the direction of reaction vessel along light beam.
8. according to the stirrer of the automatic analysis of claim 1, it is characterized in that above-mentioned stirring parts allows to analyze the zone that light beam passes through in reaction vessel vertical cross-section is greater than the vertical cross-section that does not allow to analyze the zone that light beam passes through.
9. the stirrer of automatic analyzer according to Claim 8 is characterized in that, above-mentioned stirring parts has spiral profile.
10. the stirrer of automatic analyzer according to Claim 8 is characterized in that, above-mentioned stirring parts is a vertically arranged flat board, has several through holes in the zone that this flat board allows the analysis light beam to pass through in container.
11. the stirrer according to the automatic analyzer of claim 1 is characterized in that, above-mentioned stirring parts will be carried out temperature control when entering reaction vessel.
12. the stirrer according to the automatic analyzer of claim 1 is characterized in that above-mentioned stirring parts is carried out stirring operation by ultrasonic vibration.
13. the stirrer according to the automatic analyzer of claim 1 is characterized in that above-mentioned stirring parts can automatically be controlled stirring operation according to the Interventions Requested of analysis cycle.
14. automatically supply with sample and reagent stirs, then sample is carried out the stirrer of the automatic analyzer of optical analysis for one kind in reaction vessel and in container, it is characterized in that this stirrer contains a dismountable stirring parts.
CN 96107568 1996-05-29 1996-05-29 Agitator of automatic analyzer Pending CN1166599A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 96107568 CN1166599A (en) 1996-05-29 1996-05-29 Agitator of automatic analyzer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 96107568 CN1166599A (en) 1996-05-29 1996-05-29 Agitator of automatic analyzer

Publications (1)

Publication Number Publication Date
CN1166599A true CN1166599A (en) 1997-12-03

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Application Number Title Priority Date Filing Date
CN 96107568 Pending CN1166599A (en) 1996-05-29 1996-05-29 Agitator of automatic analyzer

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107179414A (en) * 2016-03-10 2017-09-19 西门子医学诊断产品有限责任公司 Method for mixing liquid in automatic analyzer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107179414A (en) * 2016-03-10 2017-09-19 西门子医学诊断产品有限责任公司 Method for mixing liquid in automatic analyzer

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