CN116617323A - Preparation for soothing liver and improving nutrition metabolism of poultry and preparation method thereof - Google Patents
Preparation for soothing liver and improving nutrition metabolism of poultry and preparation method thereof Download PDFInfo
- Publication number
- CN116617323A CN116617323A CN202310502386.5A CN202310502386A CN116617323A CN 116617323 A CN116617323 A CN 116617323A CN 202310502386 A CN202310502386 A CN 202310502386A CN 116617323 A CN116617323 A CN 116617323A
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- Prior art keywords
- preparation
- liver
- poultry
- improving
- phosphate buffer
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Classifications
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Abstract
The invention discloses a preparation for soothing liver and improving nutrition metabolism of poultry and a preparation method thereof, belonging to the technical field of veterinary medicine preparations, wherein the preparation comprises the following components: 3-5g of eucommia ulmoides leaves, 3-5g of perilla seeds, 2-4g of white paeony roots, 2-4g of szechuan lovage rhizome, 5-6g of Chinese angelica, 4-5g of roses, 4-6g of green tangerine peel, 3-6g of nutgrass galingale rhizome, 4-5g of taurine, 4-5g of vine tea flavone, 4-6g of lactobacillus, 4-6g of maltose, 6-8g of soybean lecithin, 2-3g of cholesterol, 1-2g of nonionic surfactant, 20-25mL of propylene glycol and a phosphate buffer solution with pH value of=5.8, wherein the phosphate buffer solution is added to 100mL. The preparation of the invention adopts the compatibility principle of monarch, minister, assistant and guide of traditional Chinese medicines, and is used for soothing liver and protecting liver of animals, improving liver function and improving the problem of abnormal nutrition metabolism of animals.
Description
Technical Field
The invention belongs to the field of veterinary medicine preparations, and in particular relates to a preparation for soothing liver and improving nutrition metabolism of poultry and a preparation method thereof.
Background
The liver is the largest digestive gland in poultry, and is also an important organ with the most vigorous in vivo substance metabolism, energy metabolism and substance conversion and the most diversified functions.
The liver participates in the metabolism of protein, sugar, lipid, vitamin, hormone and other nutritive matters, and is the most important detoxication organ and immune organ of the organism. Its functions involve the functions of substance metabolism, bioconversion, bile generation and secretion, coagulation, endocrine regulation, and immunity; but also plays a very important role in maintaining body temperature, regulating blood circulation volume and regulating water distribution balance inside and outside blood vessels.
The nutritional metabolism diseases mainly comprise gout, fatty liver hemorrhage syndrome, vitamin A and vitamin B 1 Vitamin B 2 Vitamin D, vitamin E deficiency, selenium deficiency, calcium deficiency, phosphorus deficiency and the like have great influence on the production performance of poultry, and also directly influence the benefits of farmers, and how to regulate the nutrition metabolism of the poultry by improving the liver function is the content of the patent attention of the invention.
Taurine is a component of cholic acid synthesized by livers in animals, and the taurine is added into the feed to promote bile excretion.
The main component in eucommia ulmoides leaves is chlorogenic acid, which has obvious protective effect on liver injury and obviously reduces the severity of pathological liver injury. Can also promote bile secretion and promote toxin discharge.
Ampelopsis grossedentata flavone has strong antioxidation effect, can effectively remove free radicals and protect liver cells; can increase lymphocyte number, improve animal immune organ index, and improve immunity and disease resistance.
Zi is good at lung meridian. Has the functions of reducing qi, resolving phlegm, relieving asthma and moistening intestines. Can promote development of animal immune organ, enhance nonspecific immunity, and improve immunity and disease resistance; improving the development of internal organs such as liver, gall, spleen, kidney and the like of animals, and improving the capability of organism to synthesize protein.
Bai Shao enters liver and spleen meridians. Calm liver and relieve pain, nourish blood and astringe yin. White peony root can also enhance phagocytic function of mononuclear macrophage system so as to raise immunoregulatory function of animal, and can protect liver, kidney and cardiovascular system.
Chuan Xiong enters liver, gall bladder and pericardium meridians. Promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain. Has antihistaminic and cholagogic effects.
Dang Gui enters liver, heart and spleen meridians. Replenishing blood, nourishing blood, promoting blood circulation, relieving pain, moistening dryness and relaxing bowels. The Chinese angelica can enhance the immune function of organisms, and polysaccharide in the Chinese angelica can activate immune cells such as macrophages and lymphocytes and can also increase the formation of antibodies, thereby enhancing the immune function.
The rose is good at nourishing liver and spleen meridians. Promoting qi circulation, resolving stagnation, regulating blood, and relieving pain. The flos Rosae Rugosae has effects of promoting blood circulation, dispersing stagnated liver qi.
Qing Pi enters liver, gallbladder and stomach meridians. Liver soothing, qi breaking, food retention removing and stagnation eliminating effects. The green tangerine peel has various pharmacological effects of regulating gastrointestinal motility, promoting secretion of digestive juice, protecting liver, promoting bile flow and the like.
Nutgrass galingale rhizome, rhizoma Cyperi, enter liver, spleen and triple energizer meridians. Liver soothing, qi stagnation relieving, qi regulating, middle energizer regulating, blood circulation activating and pain relieving. Has analgesic, antiinflammatory, antipyretic, liver protecting, and gallbladder function promoting effects.
The liposome is used as a targeting preparation, and can be phagocytized by reticuloendothelial system after entering the body, and the reticuloendothelial system is mainly distributed in liver, spleen, lung and other tissues, so that the liposome is enriched in the liver in a targeting way.
The fermentation technology of the traditional Chinese medicine has the effects of increasing curative effect, reducing toxicity, improving availability and the like, so that the microecology and the traditional Chinese medicine have synergistic effect, and the maximum effect of the microecology and the traditional Chinese medicine is stimulated.
Disclosure of Invention
One of the purposes of the invention is to provide a preparation for soothing liver and improving the nutrition metabolism of poultry.
The second object of the present invention is to provide a method for preparing the above preparation.
The third object of the invention is to provide the application of the preparation in preparing medicines for preventing and treating gout of poultry.
In order to achieve the above purpose, the invention adopts the following technical scheme:
a preparation for soothing liver and improving nutrition metabolism of poultry comprises the following components: 3-5g of eucommia ulmoides leaves, 3-5g of perilla seeds, 2-4g of white paeony roots, 2-4g of szechuan lovage rhizome, 5-6g of Chinese angelica, 4-5g of roses, 4-6g of green tangerine peel, 3-6g of nutgrass galingale rhizome, 4-5g of taurine, 4-5g of vine tea flavone, 4-6g of lactobacillus, 4-6g of maltose, 6-8g of soybean lecithin, 2-3g of cholesterol, 1-2g of nonionic surfactant, 20-25mL of propylene glycol and a phosphate buffer solution with pH value of=5.8, wherein the phosphate buffer solution is added to 100mL.
Preferably, the viable count of lactic acid bacteria is ≡ 100 hundred million CFU/g.
Preferably, the nonionic surfactant is formed by mixing tween-80 and span-80 according to a mass ratio of 1:1.
The preparation method of the preparation for soothing liver and improving poultry nutrition metabolism comprises the following steps:
(1) Taking eucommia ulmoides leaves, perilla seeds, white paeony root, szechuan lovage rhizome, chinese angelica, rose, green tangerine peel and nutgrass galingale rhizome, respectively crushing the eucommia ulmoides leaves, the perilla seeds, the white paeony root, the szechuan lovage rhizome, the Chinese angelica, the rose, the green tangerine peel and the nutgrass galingale rhizome to 100-150 meshes, uniformly mixing, and sterilizing for standby;
(2) Adding lactobacillus and maltose into purified water, dissolving, adding into the mixture obtained in the step (1), and stirring uniformly; placing the mixture in a fermentation tank, and fermenting for 40-50 hours at the constant temperature of 35+/-2 ℃;
(3) Taking 40mL of phosphate buffer solution with pH value of 5.8, adding taurine and ampelopsis grossedentata flavone, and continuously stirring until the taurine and ampelopsis grossedentata flavone are dissolved for later use;
(4) Adding the solution obtained in the step (3) into the material obtained in the step (2), and uniformly stirring;
(5) Taking propylene glycol, adding soybean lecithin, cholesterol and a nonionic surfactant, heating to 70-80 ℃, stirring at constant temperature until the materials are completely dissolved, and cooling for later use;
(6) And (3) adding the solution obtained in the step (5) into the solution obtained in the step (4) under the stirring state, and using a phosphate buffer solution with pH=5.8 to fix the volume to 100mL, emulsifying and homogenizing to obtain the liposome.
Further, the sterilization in the step (2) means high-temperature sterilization at 12-130 ℃ for 10-20 minutes.
Further, in the step (6), the pressure of the homogenizing machine is 1000 Bar to 2000Bar during emulsification and homogenization, and the emulsification and homogenization time is 5 to 10 minutes.
Wherein the ph=5.8 phosphate buffer is formulated as follows: 8.34g of monopotassium phosphate and 0.87g of dipotassium phosphate are taken, and water is added to dissolve the monopotassium phosphate and the dipotassium phosphate into 1000mL to obtain the aqueous solution.
The application method of the preparation comprises the following steps: can be mixed with water 50kg per 100ml for long term use.
The invention adopts a process combining liposome and traditional Chinese medicine fermentation, wherein the traditional Chinese medicine is firstly subjected to solid fermentation together with probiotics, and then is prepared into the liposome, so that the curative effect of the medicine is improved, the targeting effect is also achieved, and the formula adopts the traditional Chinese medicine compound, so that the liver can be soothing liver, the liver function can be enhanced, the organism immunity can be enhanced, and the nutrition metabolism of birds can be well improved.
The invention has the advantages and beneficial effects that: (1) The preparation adopts the compatibility principle of monarch, minister, assistant and guide of traditional Chinese medicines, and is used for soothing liver and protecting liver of animals, improving liver function and improving the problem of abnormal nutrition metabolism of animals; (2) The invention adopts the traditional Chinese medicine micro powder to prepare liposome which is selectively distributed in the liver, activates the action of the medicine and greatly improves the curative effect of the medicine entering the body; (3) The invention adopts oral preparation, is convenient for clinical administration, is suitable for group administration, and saves manpower and material resources.
Detailed Description
The present invention will be further described by way of examples, but the scope of the present invention is not limited thereto.
Example 1 preparation of a formulation for soothing liver and improving nutrient metabolism in poultry
The components of the composition are as follows: 3g of eucommia ulmoides leaf, 5g of perilla seed, 2g of white peony root, 4g of ligusticum wallichii, 5g of angelica sinensis, 5g of rose, 4g of green tangerine peel, 6g of rhizoma cyperi, 4g of taurine, 5g of vine tea flavone, 4g of lactobacillus, 6g of maltose, 6g of soybean lecithin, 3g of cholesterol, 1g of nonionic surfactant (mixed by tween-80 and span-80 according to a mass ratio of 1:1), 25mL of propylene glycol and the addition of phosphate buffer (pH 5.8) to 100mL.
The preparation process comprises the following steps:
(1) Pulverizing folium Eucommiae, fructus Perillae, radix Paeoniae alba, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, flos Rosae Rugosae, pericarpium Citri Reticulatae viride, and rhizoma Cyperi respectively to 120 mesh, mixing, sterilizing at 121deg.C for 15 min, and cooling;
(2) Adding purified water into lactobacillus and maltose, dissolving, adding into the mixture obtained in step (1), stirring, placing into a fermentation tank, and fermenting at 35+ -2deg.C for 48 hr;
(3) Taking 40mL of phosphate buffer (pH 5.8), adding taurine and ampelopsis grossedentata flavone, and continuously stirring until the taurine and the ampelopsis grossedentata flavone are dissolved for later use;
(4) Adding the solution obtained in the step (3) into the material obtained in the step (2), and uniformly stirring;
(5) Taking propylene glycol, adding soybean lecithin, cholesterol and a nonionic surfactant, heating to 80 ℃, stirring at constant temperature until the materials are completely dissolved, and cooling for standby;
(6) And (3) adding the solution in the step (5) into the solution in the step (4) under the stirring state, fixing the volume to 100mL by using phosphate buffer (pH 5.8), and emulsifying and homogenizing by 1000 Bar for 10 minutes to obtain the liposome.
Wherein the ph=5.8 phosphate buffer is formulated as follows: 8.34g of monopotassium phosphate and 0.87g of dipotassium phosphate are taken, and water is added to dissolve the monopotassium phosphate and the dipotassium phosphate into 1000mL to obtain the aqueous solution.
The application method of the preparation comprises the following steps: can be mixed with water 50kg per 100ml for long term use.
Example 2 preparation of formulations for soothing liver and improving nutrient metabolism in poultry
The components of the composition are as follows: 5g of eucommia ulmoides leaf, 3g of perilla seed, 4g of white peony root, 2g of ligusticum wallichii, 6g of angelica sinensis, 4g of rose, 6g of green tangerine peel, 3g of rhizoma cyperi, 5g of taurine, 4g of vine tea flavone, 6g of lactobacillus, 4g of maltose, 8g of soybean lecithin, 2g of cholesterol, 2g of nonionic surfactant (mixed by tween-80 and span-80 according to a mass ratio of 1:1), 20mL of propylene glycol and a phosphate buffer (pH 5.8) to 100mL.
The preparation process comprises the following steps:
(1) Pulverizing folium Eucommiae, fructus Perillae, radix Paeoniae alba, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, flos Rosae Rugosae, pericarpium Citri Reticulatae viride, and rhizoma Cyperi respectively to 120 mesh, mixing, sterilizing at 121deg.C for 15 min, and cooling;
(2) Adding purified water into lactobacillus and maltose, dissolving, adding into the mixture obtained in step (1), stirring, placing into a fermentation tank, and fermenting at 35+ -2deg.C for 48 hr;
(3) Taking 40mL of phosphate buffer (pH 5.8), adding taurine and ampelopsis grossedentata flavone, and continuously stirring until the taurine and the ampelopsis grossedentata flavone are dissolved for later use;
(4) Adding the solution obtained in the step (3) into the material obtained in the step (2), and uniformly stirring;
(5) Taking propylene glycol, adding soybean lecithin, cholesterol and a nonionic surfactant, heating to 70 ℃, stirring at constant temperature until the materials are completely dissolved, and cooling for standby;
(6) And (3) adding the solution in the step (5) into the solution in the step (4) under the stirring state, and using phosphate buffer solution (pH 5.8) to fix the volume to 100mL, and emulsifying and homogenizing by 2000Bar for 5 minutes to obtain the liposome.
Wherein phosphate buffer (pH 5.8): 8.34g of monopotassium phosphate and 0.87g of dipotassium phosphate are taken, and water is added to dissolve the monopotassium phosphate and the dipotassium phosphate into 1000mL to obtain the aqueous solution.
The application method of the preparation comprises the following steps: can be mixed with water 50kg per 100ml for long term use.
Example 3 preparation of formulations for soothing liver and improving nutrient metabolism in poultry
The components of the composition are as follows: 5g of eucommia ulmoides leaf, 3g of perilla seed, 4g of white peony root, 2g of ligusticum wallichii, 6g of angelica sinensis, 4g of rose, 6g of green tangerine peel, 3g of rhizoma cyperi, 5g of taurine, 4g of vine tea flavone, 8g of soybean lecithin, 2g of cholesterol, 2g of nonionic surfactant (mixed by tween-80 and span-80 according to the mass ratio of 1:1), 20mL of propylene glycol and 100mL of phosphate buffer (pH 5.8).
The preparation process comprises the following steps:
(1) Pulverizing folium Eucommiae, fructus Perillae, radix Paeoniae alba, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, flos Rosae Rugosae, pericarpium Citri Reticulatae viride, and rhizoma Cyperi respectively to 120 mesh, mixing, sterilizing at 121deg.C for 15 min, and cooling;
(2) Taking 40mL of phosphate buffer (pH 5.8), adding taurine and ampelopsis grossedentata flavone, and continuously stirring until the taurine and the ampelopsis grossedentata flavone are dissolved for later use;
(3) Adding the solution obtained in the step (2) into the material obtained in the step (1), and uniformly stirring;
(4) Taking propylene glycol, adding soybean lecithin, cholesterol and a nonionic surfactant, heating to 70-80 ℃ and keeping the temperature, stirring until the materials are completely dissolved, and cooling for later use;
(5) And (3) adding the solution in the step (4) into the solution in the step (3) under the stirring state, and using phosphate buffer (pH 5.8) to fix the volume to 100mL, and emulsifying and homogenizing by 2000Bar for 5 minutes to obtain the liposome.
Wherein phosphate buffer (pH 5.8): 8.34g of monopotassium phosphate and 0.87g of dipotassium phosphate are taken, and water is added to dissolve the monopotassium phosphate and the dipotassium phosphate into 1000mL to obtain the aqueous solution.
Note that: in this example, the traditional Chinese medicine is not fermented.
Example 4 preparation of a control for liver soothing and improving the nutritional metabolism of poultry
The components of the composition are as follows: 5g of eucommia ulmoides leaf, 3g of perilla seed, 4g of white peony root, 2g of ligusticum wallichii, 6g of angelica, 4g of rose, 6g of green tangerine peel, 3g of nutgrass galingale rhizome, 5g of taurine, 4g of vine tea flavone, 6g of lactic acid bacteria and 4g of maltose.
The preparation process comprises the following steps:
(1) Pulverizing folium Eucommiae, fructus Perillae, radix Paeoniae alba, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, flos Rosae Rugosae, pericarpium Citri Reticulatae viride, and rhizoma Cyperi respectively to 120 mesh, mixing, sterilizing at 121deg.C for 15 min, and cooling;
(2) Adding purified water into lactobacillus and maltose, dissolving, adding into the mixture obtained in step (1), stirring, placing into a fermentation tank, and fermenting at 35+ -2deg.C for 48 hr;
(3) Vacuum drying the fermentation product at 50-55deg.C until the water content is below 10%, pulverizing, sieving, adding taurine and Ampelopsis grossedentata flavone, and mixing.
Note that: in this example, the traditional Chinese medicine is not made into liposome after fermentation.
EXAMPLE 5 Effect of the formulation of the invention on avian gout
The method is carried out according to the following steps:
drug and reagent
Test drug: the formulations prepared in examples 1, 2;
control drug: the formulations prepared in examples 3 and 4
Blank group: no preparation is added
(II) test method
(1) And (3) test design: healthy broilers 250 at 40 days of age are selected as subjects and randomly divided into 5 groups, and medicines are added to a test group and a control group respectively at the same time by improving the daily ration protein level by 20%.
The 2 test groups and the 2 control groups were each as follows: mixed drink, 50kg of water is added into every 100ml for administration, and the mixed drink is continuously used for 3 months, and free ingestion, epidemic prevention and management measures are adopted to be consistent with daily use.
Measuring the index: testing initial average weight, final average weight, feeding amount and the content of uric acid in blood.
(2) Results and analysis
TABLE 1 comparison of production Properties
Table 1 shows: the average body weight gain of the test group is 2.62, 9.17 percent higher than that of the control group 1 and the control group 2, 16.96 percent higher than that of the blank group by 32.99 percent; the average feed meat ratio of the test group was 2.305, and the control group 1 and the control group 2 were 5.42% higher and 6.29% higher than the test group and 13.67% higher than the blank group, respectively.
The results show that the preparation of the invention can obviously improve the absorption and metabolism of the poultry to nutrition under the high protein feeding condition, and improve the production performance, and meanwhile, the process conditions of the preparation of the invention show obvious difference to the use effect.
TABLE 2 determination of uric acid content in blood (unit: mg/100 ml)
Table 2 shows: during feeding, the uric acid content in the blood of the test groups 1 and 2 is not obviously different from that before the test; uric acid levels in blood of control groups 1, 2 increased prior to testing; uric acid levels in the blood of the blank group were significantly elevated compared to that before the test.
The results show that the preparation can obviously remove uric acid in blood and improve metabolic capability under the condition of high protein feeding, and meanwhile, the process conditions of the preparation have obvious difference on the use effect.
Finally, it should be noted that: the above examples are provided for illustrating the technical solution of the present invention and are not to be construed as limiting the present invention, and it should be understood by those skilled in the art that any equivalent or obvious modification of the embodiments of the present invention without changing the performance or use thereof without departing from the spirit of the present invention is intended to be included in the scope of the present invention as claimed.
Claims (8)
1. The preparation for soothing the liver and improving the nutrition metabolism of the poultry is characterized by comprising the following components: 3-5g of eucommia ulmoides leaves, 3-5g of perilla seeds, 2-4g of white paeony roots, 2-4g of szechuan lovage rhizome, 5-6g of Chinese angelica, 4-5g of roses, 4-6g of green tangerine peel, 3-6g of nutgrass galingale rhizome, 4-5g of taurine, 4-5g of vine tea flavone, 4-6g of lactobacillus, 4-6g of maltose, 6-8g of soybean lecithin, 2-3g of cholesterol, 1-2g of nonionic surfactant, 20-25mL of propylene glycol and a phosphate buffer solution with pH value of=5.8, wherein the phosphate buffer solution is added to 100mL.
2. The preparation for soothing liver and improving nutritional metabolism of poultry according to claim 1, wherein the nonionic surfactant is prepared by mixing tween-80 and span-80 according to a mass ratio of 1:1.
3. The method for preparing the preparation for soothing liver and improving nutritional metabolism of poultry according to claim 1 or 2, wherein the process is as follows:
(1) Taking eucommia ulmoides leaves, perilla seeds, white paeony root, szechuan lovage rhizome, chinese angelica, rose, green tangerine peel and nutgrass galingale rhizome, respectively crushing the eucommia ulmoides leaves, the perilla seeds, the white paeony root, the szechuan lovage rhizome, the Chinese angelica, the rose, the green tangerine peel and the nutgrass galingale rhizome to 100-150 meshes, uniformly mixing, and sterilizing for standby;
(2) Adding lactobacillus and maltose into purified water, dissolving, adding into the mixture obtained in the step (1), and stirring uniformly; placing the mixture in a fermentation tank, and fermenting for 40-50 hours at the constant temperature of 35+/-2 ℃;
(3) Taking 40mL of phosphate buffer solution with pH value of 5.8, adding taurine and ampelopsis grossedentata flavone, and continuously stirring until the taurine and ampelopsis grossedentata flavone are dissolved for later use;
(4) Adding the solution obtained in the step (3) into the material obtained in the step (2), and uniformly stirring;
(5) Taking propylene glycol, adding soybean lecithin, cholesterol and nonionic surfactant, heating to 70-80 ℃, stirring at constant temperature until all the components are dissolved, and cooling for standby;
(6) And (3) adding the solution obtained in the step (5) into the solution obtained in the step (4) under the stirring state, and using a phosphate buffer solution with pH=5.8 to fix the volume to 100mL, emulsifying and homogenizing to obtain the liposome.
4. A method for preparing a formulation for soothing liver and improving nutritional metabolism of poultry as claimed in claim 3, wherein ph=5.8
The phosphate buffer solution is prepared as follows: 8.34g of monopotassium phosphate and 0.87g of dipotassium phosphate are taken, and water is added to dissolve the monopotassium phosphate and the dipotassium phosphate into 1000mL to obtain the aqueous solution.
5. The method for preparing the preparation for soothing the liver and improving the nutrition metabolism of poultry according to claim 3, wherein the pressure of an emulsion homogenizer is 1000 Bar to 2000Bar during emulsification and homogenization, and the emulsification and homogenization time is 5 minutes to 10 minutes.
6. The method of using a formulation for soothing the liver and improving the nutritional metabolism of poultry as claimed in claim 1, wherein 50kg of water is added per 100mL.
7. Use of the formulation for soothing liver and improving nutritional metabolism of poultry according to claim 1 for preparing a medicament for preventing and treating gout in poultry.
8. The use according to claim 7, wherein the poultry is chicken.
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| CN110521877A (en) * | 2019-09-30 | 2019-12-03 | 广州邹鲁农业有限公司 | A kind of improvement chicken and the yellow-feather broiler fodder of egg quality and preparation method thereof |
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| CN110521877A (en) * | 2019-09-30 | 2019-12-03 | 广州邹鲁农业有限公司 | A kind of improvement chicken and the yellow-feather broiler fodder of egg quality and preparation method thereof |
Non-Patent Citations (3)
| Title |
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| 凌明亮: "禽痛风的发病机制及其防治方法", 湖北畜牧兽医, no. 02, 28 April 2005 (2005-04-28), pages 26 - 29 * |
| 李云鑫等: "中草药饲料添加剂在鸡养殖生产上的应用", 畜禽业, no. 04, 18 April 2020 (2020-04-18), pages 8 - 12 * |
| 闫海峰等: "中药治疗痛风相关专利用药规律分析", 天津中医药, vol. 33, no. 10, 12 October 2016 (2016-10-12), pages 629 - 633 * |
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