CN116570789A

CN116570789A - Plasma collection system and collection method

Info

Publication number: CN116570789A
Application number: CN202310855871.0A
Authority: CN
Inventors: 孟德颖; 郑少东
Original assignee: Sichuan Tianfu Nanger Biomedical Co ltd
Current assignee: Sichuan Tianfu Nanger Biomedical Co ltd
Priority date: 2023-07-13
Filing date: 2023-07-13
Publication date: 2023-08-11
Anticipated expiration: 2043-07-13
Also published as: CN116570789B

Abstract

The application relates to the technical field of plasma collection, in particular to a plasma collection system and a plasma collection method, wherein the plasma collection system comprises a management platform, an interaction unit, a control unit and a collection unit, wherein the interaction unit is in signal connection with the management platform, the interaction unit is used for inputting physical condition information of a plasma donor, and the control unit is used for receiving the physical condition information of the plasma donor, determining target data to be collected according to the physical condition information and controlling the collection process of the collection unit. The weight change of the collecting bag is monitored through the weighing module, the total weight of the pure blood plasma and the anticoagulant mixed solution in the blood plasma collecting bag is calculated according to the weight change process, and the volume of the pure blood plasma in the collecting bag is calculated through calculating the weight of the anticoagulant in the blood plasma so as to accurately control the quantity of the collected blood plasma.

Description

Plasma collection system and collection method

Technical Field

The application relates to the technical field of plasma collection, in particular to a plasma collection system and a plasma collection method.

Background

Plasma collection is a apheresis procedure in which whole blood is drawn from a donor, plasma is separated from cellular blood components (red blood cells, platelets, and white blood cells) and retained, and the cellular blood components are returned to the donor. Separation of plasma from cellular components is typically accomplished in an automated process by centrifugation or membrane filtration.

However, in operation of the conventional plasma collection system, since the collected blood contains an anticoagulant, the plasma finally collected by the plasma collection system is actually a mixture of the plasma and the anticoagulant. The anticoagulant therein naturally occupies a certain volume of the plasma collection bag, and therefore the volume of pure plasma in the plasma collection bag is actually smaller than the preset plasma collection amount of the plasma separator, resulting in an actual amount of plasma collection smaller than the preset plasma collection amount of the plasma separator.

In addition, the plasma collection system is the highest level of medical equipment as a class III medical equipment (which can be used for life support, can be implanted in human body, has potential danger to human body, has to be strictly controlled for safety and effectiveness of human life), has extremely high risk coefficient and has to be strictly controlled, so that the design and requirements thereof are very strict, and the stability, safety and real-time responsiveness of the design are strictly required.

Disclosure of Invention

The application aims to provide a plasma collection system and a collection method, which are used for accurately controlling the collection amount of plasma.

The application is realized by the following technical scheme:

the plasma collection system comprises a management platform, an interaction unit, a control unit and a collection unit, wherein the interaction unit is in signal connection with the management platform, the interaction unit is used for inputting physical condition information of a plasma donor, and the control unit is used for receiving the physical condition information of the plasma donor, determining target data to be collected according to the physical condition information and controlling the collection process of the collection unit; the acquisition unit comprises: automobile body, centrifuge, peristaltic pump, anti-coagulation pump, weighing module and collection pipeline, centrifuge, peristaltic pump, anti-coagulation pump all set up inside the automobile body, the collection pipeline includes pjncture needle, collection bag and the anti-coagulation container through the pipeline intercommunication, collection bag can be placed in the centrifugal cup and by the centrifuge drive, weighing module is used for monitoring the weight of collection bag.

In operation, since the blood collected by the conventional plasma collection system contains an anticoagulant, the plasma finally collected by the plasma collection system is actually a mixture of the plasma and the anticoagulant. The anticoagulant therein naturally occupies a certain volume of the plasma collection bag, and therefore the volume of pure plasma in the plasma collection bag is actually smaller than the preset plasma collection amount of the plasma separator, resulting in an actual amount of plasma collection smaller than the preset plasma collection amount of the plasma separator.

Based on the above problems, a plasma collection system is provided, physical condition information of a plasma donator is input through an interaction unit, collection operation of plasma is completed through a collection unit, collection operation of the collection unit is controlled through a control unit, more specifically, based on the collection unit, a collection pipeline is used for introducing whole blood through a vein puncture needle and the like, an anticoagulant pump is started at the same time, an anticoagulant in an anticoagulant container is introduced into the collection pipeline and is mixed with the whole blood, a peristaltic pump is started, a mixed solution of the whole blood and the anticoagulant is introduced into a separation cup, the separation cup is driven through a centrifuge, under the high-speed rotation effect of the centrifuge, the whole blood is centrifugally separated into a plasma layer, a white film layer and a red cell layer from inside to outside, the plasma layer is led into a collection bag, the weight change of the collection bag is monitored through a weighing module, the total weight of the pure anticoagulant mixed solution in the plasma collection bag is calculated according to the weight change process, and the total weight of the anticoagulant mixed solution in the plasma collection bag is calculated through the weight in the calculation. It should be noted that, in the above process, the key points involved include: the amount of deviation between the calculated amount and the actual amount of the anticoagulant, the amount of deviation between the weighing amount and the actual amount of the weighing module, and the like, and therefore, it is necessary to precisely control the amount of collected plasma by reducing the amount of deviation between the two points.

Further, the control unit comprises an estimation module, an estimation model is carried in the estimation module, and the estimation model is utilized to correct peristaltic pump error fluctuation, wherein the correction process comprises the compensation of peristaltic pump system errors and random errors and the estimation of peristaltic pump phase errors. It should be noted that, for the control of the conventional peristaltic pump, the anticoagulant pump and the like by the PID fuzzy controller, if the conventional PID control is adopted, it is difficult to obtain good control quality, the control structure of the conventional PID controller is single, and the setting parameter process is complicated, so that the actual movement amount of the pump is difficult to determine, and one of the calculation methods of the anticoagulant pump is to calculate by calculating the movement amount of the anticoagulant pump. Thus, the deviation in the peristaltic pump control process is compensated for by introducing the predictive module, and the compensation process can be used for peristaltic pumps or anticoagulation pumps. The correction and compensation process based on the pre-estimation module can effectively overcome the influence of errors on the pumping process, is simple to realize, has good reliability, and particularly obviously improves the pumping precision and obviously enhances the interference suppression capability.

Further, the control unit further comprises a detection module and a measuring and calculating module which are connected through signals, the detection module is used for detecting the proportion of plasma and cell components in blood, the measuring and calculating module is used for measuring and calculating the mixing proportion of anticoagulants according to the proportion, and the estimating module controls the peristaltic pump and the anticoagulation pump to rotate based on the mixing proportion of the anticoagulants and the error correction amount of the peristaltic pump. For an anticoagulation pipeline, the detection module can be realized by detecting the light transmittance of blood by a photoelectric detector in a centrifugal machine, and obtaining the specific volume of red blood cells according to the detection result, thereby obtaining the ratio of plasma to cell components; for the measuring and calculating module, the mixing ratio of the anticoagulant and the whole blood can be obtained after the hematocrit obtained by the detecting module is calculated through mathematics, wherein the mixing ratio of the anticoagulant and the whole blood refers to the volume ratio of the anticoagulant and the whole blood.

Further, the weighing module comprises a weighing sensor, an AD converter and an ARM processor which are connected through signals, wherein analog signals acquired by the weighing sensor are transmitted to the AD converter after being subjected to signal conditioning, and are transmitted to the ARM processor after being converted into corresponding digital values through AD; the signal adjusting process is to eliminate zero drift and common mode noise of the weighing sensor, and voltage signals of the weighing sensor and an analog power supply pin of the AD converter are subjected to voltage stabilization and noise filtering. Based on the above, the precision in weighing can reach 0.5ml, and the precision requirement standard in Europe can be completely met.

A method of plasma collection comprising the steps of: step 1, inputting physical condition information of a plasma donator through an interaction unit, if the physical condition information is verified to pass, performing plasma collection, and if the physical condition information is not verified to pass, not performing plasma collection; step 2, after verification in the step 1 is passed, pre-filling an anticoagulant into an anticoagulant pipeline, inputting target data and initial single-cycle acquisition quantity in an interaction unit, and starting an automatic acquisition flow of a system after performing puncture on a pulp donor; step 3, in the collection process of step 2, the peristaltic pump extracts whole blood from the vein of the plasma donor and carries out centrifugal separation, the separated cell components are left in the centrifugal cup, the blood plasma enters the collection bag to be collected, and the collection is stopped after the data of the weighing module meet the target data; and 4, after the step 3 is finished, entering a feedback flow, and enabling the peristaltic pump to feed the blood in the centrifugal cup back into the vein of the plasma donor until the centrifugal cup is empty.

Compared with the prior art, the application has the following advantages and beneficial effects:

1. the application monitors the weight change of the collecting bag through the weighing module, calculates the total weight of the pure plasma and the anticoagulant mixed solution in the plasma collecting bag according to the weight change process, and calculates the volume of the pure plasma in the collecting bag through calculating the weight of the anticoagulant in the plasma. It should be noted that, in the above process, the key points involved include: the deviation between the calculated amount and the actual amount of the anticoagulant, the deviation between the weighing amount and the actual amount of the weighing module, and the like, so that the amount of the collected plasma is accurately controlled by reducing the deviation between the two points;

2. according to the application, on the basis of double closed loop feedback adjustment of the rotating speed adjusting module, the proportion data of the blood plasma and the cell components calculated by the measuring and calculating module is introduced to perform cyclic feedback again, so that the change of the power supply current can be effectively controlled, and the real-time dynamic rotating speed adjustment can be performed according to the quantized data of the blood in the centrifugal cup, so that the rotating speed control process is more stable and smooth, the centrifugal effect is further improved, and the layering of the blood plasma is more facilitated;

3. the voltage signals of the analog power supply pins of the weighing sensor and the AD converter are subjected to voltage stabilization and noise filtering treatment, so that the precision in weighing can reach 0.5ml, and the European precision requirement standard can be completely met.

Drawings

The accompanying drawings, which are included to provide a further understanding of embodiments of the application and are incorporated in and constitute a part of this specification, illustrate embodiments of the application and together with the description serve to explain the principles of the application. In the drawings:

FIG. 1 is a schematic diagram of the system of the present application;

FIG. 2 is a flow chart of the method of the present application;

FIG. 3 is a schematic view of the appearance structure of the present application;

FIG. 4 is a schematic view of the working state structure of the present application;

FIG. 5 is a schematic structural view of an adjusting member;

FIG. 6 is a schematic view of the internal structure of the centrifuge;

FIG. 7 is a schematic circuit diagram of a rotational speed adjustment module;

FIG. 8 is a schematic view of a partial cross-sectional structure of a centrifuge;

fig. 9 is a schematic view showing a state of engagement of the centrifugal cup and the holder.

In the drawings, the reference numerals and corresponding part names:

the centrifugal device comprises a 1-car body, a 2-protection structure, a 21-telescopic part, a 22-turnover part, a 3-adjusting piece, a 4-centrifugal machine, a 5-centrifugal cup, a 31-bottom plate, a 32-adjusting motor, a 33-adjusting plate, a 34-adjusting wheel, a 35-lifting plate, a 6-rotating speed adjusting module, a 7-clamping piece, a 71-clamping arm, a 72-first connecting rod, a 73-second connecting rod, a 74-elastic piece, an 8-inertial piece, a 81-fixing rope, a 82-inertial ball and a 9-inner container.

Detailed Description

For the purpose of making apparent the objects, technical solutions and advantages of the present application, the present application will be further described in detail with reference to the following examples and the accompanying drawings, wherein the exemplary embodiments of the present application and the descriptions thereof are for illustrating the present application only and are not to be construed as limiting the present application. It should be noted that the present application is already in a practical development and use stage.

Example 1:

as shown in fig. 1, the plasma collection system comprises a management platform, and further comprises an interaction unit, a control unit and a collection unit which are in signal connection with the management platform, wherein the interaction unit is used for inputting physical condition information of a pulp donor, and the control unit is used for receiving the physical condition information of the pulp donor, determining target data to be collected according to the physical condition information and controlling the collection process of the collection unit; the acquisition unit comprises: automobile body 1, centrifuge 4, peristaltic pump, anti-coagulation pump, weighing module and collection pipeline, centrifuge 4, peristaltic pump, anti-coagulation pump all set up inside automobile body 1, the collection pipeline includes pjncture needle, collection bag and the anti-coagulation container through the pipeline intercommunication, collection bag can be placed in centrifugal cup 5 and by centrifuge 4 drives, weighing module is used for monitoring the weight of collection bag. In operation, since the blood collected by the conventional plasma collection system contains an anticoagulant, the plasma finally collected by the plasma collection system is actually a mixture of the plasma and the anticoagulant. The anticoagulant therein naturally occupies a certain volume of the plasma collection bag, and therefore the volume of pure plasma in the plasma collection bag is actually smaller than the preset plasma collection amount of the plasma separator, resulting in an actual amount of plasma collection smaller than the preset plasma collection amount of the plasma separator.

Based on the above problems, a plasma collection system is proposed, physical condition information of a plasma donator is input through an interaction unit, collection operation of plasma is completed through a collection unit, collection operation of the collection unit is controlled through a control unit, more specifically, based on the collection unit, a collection pipeline is used for introducing whole blood through a vein puncture needle and the like, an anticoagulant pump is started at the same time, an anticoagulant in an anticoagulant container is introduced into the collection pipeline through the anticoagulant pump and is mixed with the whole blood, a peristaltic pump is started, a mixed solution of the whole blood and the anticoagulant is introduced into a separation cup, the separation cup is driven through a centrifugal machine 4, under the high-speed rotation effect of the centrifugal machine 4, the whole blood is centrifugally separated into a plasma layer, a white membrane layer and a red cell layer from inside to outside, the plasma layer is led into a collection bag, weight change of the collection bag is monitored through a weighing module, total weight of the pure anticoagulant and the mixed solution in the plasma collection bag is calculated according to the weight change process, and the pure volume of the plasma in the collection bag is calculated through weight calculation. It should be noted that, in the above process, the key points involved include: the deviation between the calculated amount and the actual amount of the anticoagulant, the deviation between the weighing amount and the actual amount of the weighing module, and the like, and therefore, the amount of the collected plasma is precisely controlled by reducing the deviation between the two points.

The control unit comprises an estimation module, wherein an estimation model is carried in the estimation module, and the estimation model is utilized to correct peristaltic pump error fluctuation, wherein the correction process comprises the compensation of peristaltic pump system errors and random errors and the estimation of peristaltic pump phase errors. It should be noted that, for the control of the conventional peristaltic pump, the anticoagulant pump and the like by the PID fuzzy controller, if the conventional PID control is adopted, it is difficult to obtain good control quality, the control structure of the conventional PID controller is single, and the setting parameter process is complicated, so that the actual movement amount of the pump is difficult to determine, and one of the calculation methods of the anticoagulant pump is to calculate by calculating the movement amount of the anticoagulant pump. Thus, the deviation in the peristaltic pump control process is compensated for by introducing the predictive module, and the compensation process can be used for peristaltic pumps or anticoagulation pumps. The correction and compensation process based on the pre-estimation module can effectively overcome the influence of errors on the pumping process, is simple to realize, has good reliability, and particularly obviously improves the pumping precision and obviously enhances the interference suppression capability.

For peristaltic pumps or error analysis of peristaltic pumps, there are mainly systematic errors, random errors and deformation errors, wherein the systematic errors include phase errors, namely principle errors and manufacturing errors, and the principle errors are caused by the principle of peristaltic pumps, and the reasons include that the start and stop phases are different each time. There are related experiments showing that the phase error accounts for about 50% to 80% of the peristaltic pump errors. Thus, although random errors and deformation errors are unavoidable, the calculation of the excess can be performed by introducing a relatively fixed compensation value; for the phase error, the numerical range of the phase error can be measured through limited experiments, then the correction and compensation process is carried out, and for the test process, the aging operation is carried out for about 100 times when the test is started; the height of the liquid level at the inlet is controlled to be not more than 5cm, and the rapid needle head is selected to have no hanging drop; in order to reduce the influence of random errors, the flow is not too large, the test is selected between 10 and 30 pulses, hanging drops are generated when the flow is too small, and the random error ratio is too large to directly reflect the influence of phase errors. In order to avoid repeated calculation of the error amount in each acquisition process, the error amount is trained by introducing a predictive model. For the pre-estimated model, a gating cyclic neural network with pre-estimated capability, namely a GRU neural network model is preferable; for the predictive module, a Smith predictive controller is preferred. Specifically, the logic process is as follows: creating a time transfer function model comprising a continuous model or a discontinuous model, discretizing the transfer function model to be converted into a differential equation, acquiring a molecular denominator of the transfer function model, in other words, discrete dividing the transfer function of the function model into a training part and a pre-estimating part by creating a pre-estimating module, constructing a compensation model by utilizing the pre-estimating model of the training part, generating a compensation signal according to the pre-estimating value by the compensation model, and discharging the influence of errors by the compensation process of the pre-estimating module.

It should be noted that, the control unit further includes a detection module and a measurement module connected by signals, the detection module is used for detecting the proportion of plasma and cell components in blood, the measurement module is used for measuring and calculating the mixing proportion of anticoagulant according to the proportion, and the estimation module controls the peristaltic pump to rotate with the anticoagulant pump based on the mixing proportion of anticoagulant and the error correction amount of the peristaltic pump. For the anticoagulation pipeline, the detection module can be realized by detecting the light transmittance of blood by a photoelectric detector in the centrifugal machine 4, and obtaining the specific volume of the red blood cells according to the detection result, thereby obtaining the ratio of the blood plasma to the red blood cells; for the measuring and calculating module, the mixing ratio of the anticoagulant and the whole blood can be obtained after the hematocrit obtained by the detecting module is calculated through mathematics, wherein the mixing ratio of the anticoagulant and the whole blood refers to the volume ratio of the anticoagulant and the whole blood. It should be noted that, between the anticoagulation line and the peristaltic pump, there is a sounding point, and the main function of sounding is to detect whether there is air in the blood transfer tube path, and when there is air in the blood transfer tube path, the peristaltic pump is stopped immediately, and this time must have a strictly defined time upper limit, and this time must be less than 200ms to stop the peristaltic pump, and wait for the nurse to process. While pre-filling with anticoagulant requires the detection of the presence of anticoagulant in the line, if not, protection must be provided in less than 200 ms. This time includes both hardware and software operating times, i.e., the sum of the time the hardware has collected that air is in the tubing to stop the peristaltic pump. This requires real-time performance of the operating system selected by the system.

The weighing module comprises a weighing sensor, an AD converter and an ARM processor which are connected through signals, wherein analog signals acquired by the weighing sensor are transmitted to the AD converter after being subjected to signal conditioning, and are transmitted to the ARM processor after being converted into corresponding digital values through AD; the signal adjusting process is to eliminate zero drift and common mode noise of the weighing sensor, and voltage signals of the weighing sensor and an analog power supply pin of the AD converter are subjected to voltage stabilization and noise filtering. Based on the above, the precision in weighing can reach 0.5ml, and the precision requirement standard in Europe can be completely met. It should also be noted that, to achieve accurate measurement of the acquisition system, the analog power supply of the weighing module requires an accurate, low noise power supply signal. In order to provide a good stable point voltage signal, the weighing module circuit adopts a precise low-voltage-difference voltage stabilizer, such as ADP3301, which can realize stable operation by adopting any type of capacitor, and the ESR (equivalent series resistance) value is not limited. Excellent accuracy of 0.8% can be realized at room temperature, and the overall accuracy of temperature, line and load adjustment is + -1.4%.

Example 2:

this example describes only the portions different from example 1, specifically:

as shown in fig. 2, a plasma collection method comprises the following steps: step 1, inputting physical condition information of a plasma donator through an interaction unit, if the physical condition information is verified to pass, performing plasma collection, and if the physical condition information is not verified to pass, not performing plasma collection; step 2, after verification in the step 1 is passed, pre-filling an anticoagulant into an anticoagulant pipeline, inputting target data and initial single-cycle acquisition quantity in an interaction unit, and starting an automatic acquisition flow of a system after performing puncture on a pulp donor; step 3, in the collection process of step 2, the peristaltic pump extracts whole blood from the vein of the plasma donor and carries out centrifugal separation, the separated cell components are left in the centrifugal cup 5, the blood plasma enters a collection bag to be collected, and the collection is stopped after the data of the weighing module meet the target data; and 4, after the step 3 is finished, entering a feedback flow, and enabling the peristaltic pump to feed the blood in the centrifugal cup 5 back into the vein of the plasma donor until the centrifugal cup 5 is empty.

The physical condition information includes, but is not limited to: age requirement data, physical examination data, blood sample detection data, pre-harvest check data, temporary rejection data and the like, wherein for the age requirement data, 18 to 55 years old are age-appropriate pulp collection groups, and identification cards are identified by a system to register and limit people in non-age groups; for physical examination data, the physical examination data comprises parameter data such as blood pressure, weight, pulse, body temperature and the like; for blood sample detection data, the blood sample detection data mainly comprises five index detection of AIDS, syphilis, hepatitis B, hepatitis C and transaminase, and the detection qualified parameter standard is set, and the automatic judgment of the higher than standard parameter is unqualified and the automatic judgment of the lower than standard parameter is qualified; for the pre-harvest check data, the pre-harvest check data can be identity identification through an identity card and the like; and for temporary rejection data, the temporary rejection data is used for carrying out system identification on the people who have been subjected to temporary rejection, and automatic prompt is carried out in the next registration, so that the situation that the part of people do not carefully flow into the next process and even plasma collection is avoided.

Example 3:

in the foregoing, the software level of the plasma collection system has been described, and the description of the hardware level of the plasma collection system is first performed, more specifically:

referring to fig. 3 to 6, the vehicle body 1 is a frame structure of a mobile blood sampling system, the inside of the frame structure is hollow and accommodates a centrifuge 4, a peristaltic pump and an anticoagulant pump, a protecting structure 2 is arranged above the vehicle body 1, the protecting structure 2 mainly comprises a turnover part 22 and a telescopic part 21, the turnover part 22 and the telescopic part 21 are made of organic glass, the telescopic part 21 can stretch downwards when the collection preparation work, the turnover part 22 is turned upwards again, an image collection device and a display screen for face recognition are integrated on the lower end face of the turnover part 22, and a hook for placing a collection pipeline is arranged. Considering the space volume utilization and carrying problems, it is preferable in this embodiment that: the inside of automobile body 1 still is provided with regulating part 3, centrifuge 4 can realize high regulation and keep dynamic balance through regulating part 3, regulating part 3 includes: the automobile comprises a bottom plate 31, an adjusting motor 32, an adjusting plate 33, an adjusting wheel 34 and a lifting plate 35, wherein the bottom plate 31 is contacted with the automobile body 1, the adjusting motor 32 is arranged on the bottom plate 31, an output shaft is in transmission connection with the adjusting wheel 34, the bottom plate 31 and the lifting plate 35 are oppositely arranged and can be adjusted, the cross section of the adjusting plate 33 is triangular and is slidably arranged at the lower end of the lifting plate 35, and a toothed belt which can be meshed with the adjusting wheel 34 is arranged on the surface where the inclined edge of the adjusting plate 33 is positioned. The sliding of the adjusting plate 33 and the lifting plate 35 is set to be a dovetail groove or a T-shaped groove, when the adjusting motor 32 is started, the adjusting wheel 34 can be driven to rotate, so that the sliding of the adjusting plate 33 in the groove is realized, and finally, the stepless height adjustment of the lifting plate 35 in the vertical direction is realized.

Example 4:

in this embodiment, only the differences from embodiment 3 are described, and specifically, for the centrifuge 4, the current single plasma sampling machine on the market mainly adopts a negative feedback control scheme of the rotational speed of the dc motor based on the control of the single chip microcomputer. In practice it has been found that this solution has the following drawbacks for such a constant speed operation system of the plasma centrifuge 4, the system control performance index is mainly immunity. The reasons for influencing the rotational speed are mainly the variation of the supply current and the amount of blood in the centrifuge cup 5. In a single closed-loop speed regulating system, the action point of the power grid voltage disturbance is far away from the regulated quantity, the regulating action is delayed by a plurality of links, and the single closed-loop speed regulating system has poor disturbance resistance.

Based on this, as shown in fig. 7, the control unit of the present application further includes a rotation speed adjusting module 6 in signal connection with the measuring module, where the rotation speed adjusting module 6 includes a main circuit, a detection circuit, a control circuit, a given circuit and a display circuit in signal connection, and the detection circuit is used for detecting voltage, current and rotation speed, and the detected current and voltage signals need to be sent to the measuring module after a/D conversion due to the amplitude and polarity problems. For the control circuit, including signal connection: the motor speed regulator comprises an outer ring regulator, an inner ring regulator, a converter, a current transformer and a speed measuring piece, wherein the outer ring regulator is a leading regulator of a control circuit, so that the motor speed can quickly follow given voltage change, the speed error can be reduced in a steady state, and the motor speed regulator plays an anti-disturbance role on load change; the inner ring regulator makes current change along with given voltage (output quantity of the outer ring regulator) in the control process of the outer ring rotating speed, plays a role in resisting disturbance in time on fluctuation of power grid voltage, and can ensure that maximum current allowed by a motor is obtained in the dynamic control and regulation process of the rotating speed, so that the dynamic regulation process of the motor is quickened. Furthermore, in the feedback regulation process of the outer ring, the proportion of the blood plasma and the cell component calculated by the measuring and calculating module is introduced, and the rotating speed is dynamically feedback-regulated according to the proportion. As shown in fig. 7, ASR is an outer ring regulator, ACR is an outer ring regulator, TA is a current transformer, G is a speed measuring piece, GT is a converter, and the proportion data of the blood plasma and the cell components calculated by the measuring and calculating module are introduced to perform the circulating feedback again on the basis of the double closed-loop feedback regulation of the rotating speed regulating module 6, so that the change of the power supply current can be effectively controlled, the real-time dynamic rotating speed regulation can be performed according to the quantized data of the blood in the centrifugal cup 5, the rotating speed control process is more stable and smooth, the centrifugal effect is further improved, and the plasma layering is more facilitated.

Example 5:

in this embodiment, only the portion differing from embodiment 3 is described, specifically, in order to improve the stability of the centrifugal cup 5 during centrifugation, as shown in fig. 9, a clamping member 7 for improving the stability is further provided on the outer circumferential surface of the centrifugal cup 5, the clamping member 7 includes clamping arms 71 distributed in a circumferential array, the clamping arms 71 include a first link 72 contacting the inner container 9 of the centrifuge 4, a second link 73 hinged to the free end of the first link 72, and an elastic member 74 hinged to the free end of the second link 73, and the elastic member 74 and the second link 73 have a tendency to bend inwards. Based on the above structure, the clamping member 7 can dynamically correct and clamp the rotating centrifugal cup 5 in real time, the outer surfaces of the second connecting rod 73 and the elastic member 74 are coated with wear-resistant materials, and the bending trend of the elastic member 74 and the second connecting rod 73 can be realized by a spring and other structures.

Example 6:

in this embodiment, only the portion different from embodiment 3 is described, specifically, in order to further improve the stability of the centrifugal cup 5 during centrifugation, as shown in fig. 8, an inertial member 8 for rotating inertia is further disposed on the outer peripheral surface of the centrifugal cup 5, the inertial member 8 includes a fixing rope 81, one end of the fixing rope 81 is slidably disposed in the inner container 9, the other end of the fixing rope is slidably disposed in the outer peripheral surface of the centrifugal cup 5, and an inertial ball 82 is movably disposed on the fixing rope 81, so that when the centrifugal cup 5 rotates, the inertial member 8 can simultaneously rotate. The connection implementation form of the fixing rope 81 and the inner container 9 can be as follows: a sliding rail is arranged on the inner wall of the inner container 9, a sliding block is arranged on the sliding rail, the sliding block is fixedly connected with one end of the fixed rope 81, and the height of the sliding rail is not adjustable; the connection realization form of the fixing rope 81 and the centrifugal cup 5 can be as follows: the outer peripheral surface of the centrifugal cup 5 is also provided with a sliding block, and the sliding rail is also provided with a sliding block, which is different in that: the other end and the slider swing joint of fixed rope 81 promptly can carry out the altitude mixture control in vertical direction, and the altitude mixture control process is controllable, like forms such as miniature numerical control slide rail realize, based on above-mentioned structure, and this altitude mixture control bind with the plasma layer place height, adjusts the altitude mixture control of fixed rope 81 other end place height according to the plasma layer information of gathering promptly. During the rotation of the centrifugal cup 5, under the action of the rotating inertia ball 82, the plasma layer where the centrifugal cup 5 is positioned has higher rotation inertia, which is beneficial to the differential centrifugation of the plasma layer.

Example 7:

the medical system must ensure the correctness of the operation of the system, and the medical system must be operated when the operation is needed and stopped when the operation is needed. Otherwise, medical accidents that harm the life safety of the human body may occur. Therefore, on the basis of the above, it is proposed that when resource access is performed among the management platform, the interaction unit, the control unit and the acquisition unit, the following conditions are satisfied: the upper limit of the priority of the task accessing the resource is equal to or greater than the maximum of the priorities of all the tasks accessing this resource; the upper limit of the priority of the task accessing the resource is less than the minimum priority of all tasks not accessing the resource.

When a task needs a resource and locks the resource, the priority of the task is temporarily raised to the maximum value of the priority of the resource; when the task runs out of resources and unlocks the resources, the priority of the task is restored to the static value of the priority originally defined.

Deadlock can be prevented by setting the order of resource applications or can be avoided if the execution of the critical section is atomic. If the running task occupies the mutex lock and inherits the high priority of the task through the mutex lock, and when the task releases the mutex lock, the inherited priority of the task should be raised to the highest priority capable of inheriting the priority of the task in all the mutex locks owned by the task, and the protocol for preventing the priority inversion adopting the concept is a priority ceiling protocol. Based on the content, the real-time performance of data resource access among the acquisition systems can be greatly improved, and the acquisition efficiency is improved.

The foregoing description of the embodiments has been provided for the purpose of illustrating the general principles of the application, and is not meant to limit the scope of the application, but to limit the application to the particular embodiments, and any modifications, equivalents, improvements, etc. that fall within the spirit and principles of the application are intended to be included within the scope of the application.

Claims

1. A plasma collection system comprising a management platform, characterized in that: the system also comprises an interaction unit, a control unit and an acquisition unit which are connected with the management platform through signals, wherein the interaction unit is used for inputting physical condition information of the pulp donor, and the control unit is used for receiving the physical condition information of the pulp donor, determining target data to be acquired according to the physical condition information and controlling the acquisition process of the acquisition unit;

the acquisition unit comprises: automobile body (1), centrifuge (4), peristaltic pump, anti-coagulation pump, weighing module and collection pipeline, centrifuge (4), peristaltic pump, anti-coagulation pump all set up inside automobile body (1), the collection pipeline includes pjncture needle, collection bag and anti-coagulation container through the pipeline intercommunication, collection bag can be placed in centrifugal cup (5) and by centrifuge (4) drive, weighing module is used for monitoring the weight of collection bag.

2. A plasma collection system according to claim 1, wherein: the control unit comprises an estimation module, an estimation model is carried in the estimation module, and the estimation model is utilized to correct peristaltic pump error fluctuation, wherein the correction process comprises the compensation of peristaltic pump system errors and random errors and the estimation of peristaltic pump phase errors.

3. A plasma collection system according to claim 2, wherein: the control unit also comprises a detection module and a measuring and calculating module which are connected through signals, wherein the detection module is used for detecting the proportion of plasma and cell components in blood, the measuring and calculating module is used for measuring and calculating the mixing proportion of the anticoagulant according to the proportion, and the estimating module is used for controlling the peristaltic pump and the anticoagulant pump to rotate based on the mixing proportion of the anticoagulant and the error correction amount of the peristaltic pump.

4. A plasma collection system according to claim 1, wherein: the weighing module comprises a weighing sensor, an AD converter and an ARM processor which are connected through signals, wherein analog signals acquired by the weighing sensor are transmitted to the AD converter after being subjected to signal conditioning, and are transmitted to the ARM processor after being converted into corresponding digital values through AD;

the signal adjusting process is to eliminate zero drift and common mode noise of the weighing sensor, and voltage signals of the weighing sensor and an analog power supply pin of the AD converter are subjected to voltage stabilization and noise filtering.

5. A method for collecting plasma, characterized in that: a plasma collection system according to any one of claims 1 to 4, comprising the steps of:

step 1, inputting physical condition information of a plasma donator through an interaction unit, if the physical condition information is verified to pass, performing plasma collection, and if the physical condition information is not verified to pass, not performing plasma collection;

step 2, after verification in the step 1 is passed, pre-filling an anticoagulant into an anticoagulant pipeline, inputting target data and initial single-cycle acquisition quantity in an interaction unit, and starting an automatic acquisition flow of a system after performing puncture on a pulp donor;

step 3, in the collection process of step 2, the peristaltic pump extracts whole blood from the vein of the plasma donor and carries out centrifugal separation, the separated cell components are left in a centrifugal cup (5), the blood plasma enters a collection bag to be collected, and the collection is stopped after the data of the weighing module meets the target data;

and 4, after the step 3 is finished, entering a feedback flow, and enabling the peristaltic pump to feed the blood in the centrifugal cup (5) back into the vein of the plasma donor until the centrifugal cup (5) is empty.