CN116531802B - Cistanche deserticola polysaccharide obtaining and purifying equipment and method - Google Patents

Cistanche deserticola polysaccharide obtaining and purifying equipment and method Download PDF

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Publication number
CN116531802B
CN116531802B CN202310554539.0A CN202310554539A CN116531802B CN 116531802 B CN116531802 B CN 116531802B CN 202310554539 A CN202310554539 A CN 202310554539A CN 116531802 B CN116531802 B CN 116531802B
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resin filter
mandrel
purification
tank body
cistanche deserticola
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CN116531802A (en
Inventor
李国锋
李明泽
赵保堂
黄玉龙
尚琪
刘�东
张芳
李玉新
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Agricultural Products Storage & Processing Institute Gansu Academy Of Agricultural Sciences
Gansu Agricultural University
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Agricultural Products Storage & Processing Institute Gansu Academy Of Agricultural Sciences
Gansu Agricultural University
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    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003General processes for their isolation or fractionation, e.g. purification or extraction from biomass
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/02Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor with moving adsorbents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/10Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/42Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424Elution mode
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/10Process efficiency

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Sustainable Development (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

The invention relates to the field of cistanche deserticola polysaccharide purification, in particular to cistanche deserticola polysaccharide acquisition and purification equipment and a cistanche deserticola polysaccharide acquisition and purification method, which comprise a tank body, wherein a mandrel is fixedly penetrated in the middle of the tank body, and a liquid inlet is penetrated at the top of the tank body; the ring frame rotates outside the mandrel, the edge of the ring frame, the edge of the tank body and the side wall form a plurality of evenly distributed accommodating grooves, resin filter bodies are placed in the accommodating grooves, and one end of the accommodating grooves, which is close to the mandrel, is a net surface; the purification passage is arranged at the upper part of the mandrel; the water washing component is arranged at the lower part of the mandrel, the annular resin filter bodies are adopted to form a plurality of continuous purification stations, the resin filter bodies at the upper part are used for filtering, adsorbing and purifying the cistanche deserticola polysaccharide, the resin filter bodies at the lower part are subjected to backwashing and desorption by the water washing component, the cistanche deserticola polysaccharide is continuously and efficiently purified by rotating and transposition of each resin filter body, and the resin filter bodies are subjected to backwashing and desorption, so that the service life is prolonged, and the method is suitable for continuous purification processing of the cistanche deserticola polysaccharide.

Description

Cistanche deserticola polysaccharide obtaining and purifying equipment and method
Technical Field
The invention relates to the field of cistanche deserticola polysaccharide purification, in particular to cistanche deserticola polysaccharide acquisition and purification equipment and a cistanche deserticola polysaccharide acquisition and purification method.
Background
Cistanche deserticola polysaccharide is one of main components of cistanche deserticola pharmacological action, and has the effects of improving immunity, promoting DNA synthesis, enhancing physical strength, improving intelligence, and resisting aging, and the purity of the polysaccharide directly influences the pharmacological action degree;
in the cistanche polysaccharide obtaining process and the cistanche crude sugar purifying process, organic solvent treatment is needed, then the treatment solution is filtered by macroporous resin, impurities and pigments in the extraction solution are removed, and the purer extraction solution is obtained.
Disclosure of Invention
The invention aims to solve the following problems in the prior art: the traditional process is to add the extracting solution into a macroporous resin column, automatically filter under normal pressure, gradually saturate the macroporous resin with increasing treatment capacity, and filter the macroporous resin after replacement, so that the requirement of industrial continuous treatment of cistanche deserticola polysaccharide is difficult to meet.
The invention provides desert cistanche polysaccharide obtaining and purifying equipment for solving the problems in the prior art, which comprises a tank body, wherein a mandrel is fixedly penetrated in the middle of the tank body, and a liquid inlet is penetrated in the top of the tank body;
the ring frame rotates outside the mandrel, the edge of the ring frame, the edge of the tank body and the side wall form a plurality of evenly distributed accommodating grooves, resin filter bodies are placed in the accommodating grooves, and one end of the accommodating groove, which is close to the mandrel, is a net surface;
a purification passage provided at an upper portion of the mandrel;
the driving assembly is used for driving the ring frame to rotate, so that the upper accommodating groove is alternately aligned with the purification passage, the cistanche deserticola polysaccharide extracting solution enters the upper accommodating groove from the liquid inlet, and the cistanche deserticola polysaccharide extracting solution penetrates the resin filter body from top to bottom and is discharged from the purification passage;
and the water washing assembly is arranged at the lower part of the mandrel and used for washing the resin filter body in the lower accommodating groove.
Preferably, the driving assembly comprises a motor, the motor is connected with the ring frame through gear transmission, a flow sensor is arranged in the liquid inlet, and the flow sensor and the motor are connected with a controller together.
Preferably, the purification passage comprises an upper liquid cavity, the upper liquid cavity is arranged on the upper portion of the mandrel, a net surface is arranged on the upper portion of the surface of the mandrel and used for penetrating through the accommodating groove and the upper liquid cavity, and one end of the upper liquid cavity is connected with the liquid outlet.
Preferably, the washing assembly comprises a lower liquid cavity and a liquid pump, the lower liquid cavity is arranged at the lower part of the mandrel, a net surface is arranged at the lower part of the surface of the mandrel and used for penetrating through the accommodating groove and the lower liquid cavity, the drainage end of the liquid pump is connected with the lower liquid cavity, and a waste discharge port is arranged at the bottom of the tank body.
Preferably, the cavity inside the tank body is disc-shaped, the bottom of the cavity inside the tank body extends to form an arc-shaped expansion part, the resin filter body is at least provided with two split parts, the split parts are connected through springs, and the accommodating groove is aligned with the arc-shaped expansion part to enable the split parts of the resin filter body to be unfolded.
Preferably, the section of the accommodating groove is trapezoid, and the split part of the resin filter body is closed and matched with the accommodating groove.
Preferably, the split parts of the resin filter body are connected through telescopic pieces, the telescopic pieces comprise telescopic pipes and telescopic rods which are mutually spliced, and the telescopic pipes and the telescopic rods are respectively and fixedly connected with the split parts at two ends.
Preferably, the telescopic pipe is fixedly penetrated through the split part near the mandrel, the end part of the telescopic rod is provided with a reducing port, the inner end of the telescopic rod is provided with a plunger part adapting to the reducing port, the surface of the telescopic rod is provided with an axially extending through groove, the surface of the telescopic rod is provided with a through hole penetrating through the through groove, and the through hole is opposite to a gap between the split parts when the split part is unfolded.
A purification method based on the cistanche deserticola polysaccharide acquisition and purification equipment comprises the following specific steps:
A. introducing herba cistanches polysaccharide extract into the accommodating groove at the upper part from the liquid inlet, allowing the herba cistanches polysaccharide extract to penetrate through the resin filter body downwards to be adsorbed and purified, and discharging the purified herba cistanches polysaccharide extract from the purification passage;
B. the upper resin filter body is adsorbed and saturated, the ring frame is driven to rotate by the driving device, so that the accommodating groove and the resin filter body are rotated and transposed, and the cistanche deserticola polysaccharide extract is kept to be continuously adsorbed and purified;
C. the saturated resin filter body is rotated to the lower part of the tank body, and the resin filter body is backwashed through the water washing assembly.
Compared with the related art, the cistanche deserticola polysaccharide obtaining and purifying equipment and the cistanche deserticola polysaccharide purifying method provided by the invention have the following beneficial effects:
the invention adopts the resin filter bodies distributed in a ring shape to form a plurality of continuous purification stations, the resin filter bodies at the upper part carry out filtration, adsorption and purification on the cistanche deserticola polysaccharide, the resin filter bodies at the lower part are backwashed and desorbed by the water washing component, the rotary transposition of each resin filter body keeps continuous and efficient purification treatment on the cistanche deserticola polysaccharide, and the resin filter bodies are backwashed and desorbed, so that the service cycle is prolonged, and the invention is suitable for continuous purification processing of the industrialized cistanche deserticola polysaccharide.
Drawings
FIG. 1 is a schematic diagram of the overall structure of the present invention;
FIG. 2 is a second schematic diagram of the overall structure of the present invention;
FIG. 3 is a schematic diagram showing the distribution structure of a resin filter according to the present invention;
FIG. 4 is a schematic view of a radial cross-sectional structure of the present invention;
FIG. 5 is a schematic axial cross-sectional view of the present invention;
FIG. 6 is a schematic view showing an expanded structure of a resin filter body according to the present invention;
fig. 7 is a schematic view of the telescopic structure of the present invention.
Reference numerals in the drawings: 1. a tank body; 11 liquid inlets; 12. a liquid outlet; 2. a flow sensor; 3. a mandrel; 31. a liquid feeding cavity; 32. a liquid discharging cavity; 4. a motor; 5. a liquid pump; 51. a waste discharge port; 6. a resin filter; 7. a ring frame; 8. a telescoping member; 81. a telescopic tube; 82. a telescopic rod; 83. a through hole; 84. a plunger portion; 85. and (5) through grooves.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
Specific implementations of the invention are described in detail below in connection with specific embodiments.
Example 1
As shown in fig. 1-2, the cistanche deserticola polysaccharide obtaining and purifying device is provided with a stainless steel tank body 1, wherein a disc-shaped cavity is formed in the tank body 1, a mandrel 3 is fixedly installed by penetrating through the middle part of the tank body 1, and a liquid inlet 11 is installed on the top of the tank body 1 in a penetrating manner;
as shown in fig. 3-4, the ring frame 7 is made of stainless steel, the ring frame 7 is composed of a ring body and fan plates uniformly and radially extending from the surface of the ring body, the ring frame 7 rotates outside the mandrel 3, a plurality of uniformly distributed accommodating grooves are formed between the fan plates of the ring frame 7 and the edges and the side walls of the tank body 1, resin filter bodies 6 are placed in the accommodating grooves, and one end of each accommodating groove, which is close to the mandrel 3, is a net surface;
as shown in fig. 3-5, the purification passage comprises an upper liquid cavity 31, an upper liquid cavity 31 and a lower liquid cavity 32 which are distributed up and down are formed by dividing the inside of the mandrel 3 through a partition plate, net surfaces are arranged on the upper part and the lower part of the surface of the mandrel 3, and one end of the upper liquid cavity 31 is connected with a liquid outlet 12;
as shown in fig. 1, the driving assembly comprises a motor 4, the motor 4 is arranged outside the tank body 1, one end of a ring frame 7 rotates to penetrate out of the tank body 1, the motor 4 is connected with the ring frame 7 through gear transmission, a flow sensor 2 is arranged in a liquid inlet 11, the flow sensor 2 is electrically connected with a controller, and the controller is electrically connected with the motor 4;
when the cistanche deserticola polysaccharide is industrially purified, the cistanche deserticola polysaccharide extract is led into the tank body 1 from the liquid inlet 11, enters the accommodating groove at the upper part, is adsorbed and filtered by the resin filter body 6, enters the upper liquid cavity 31 through the net surface after being purified, and is discharged through the liquid outlet 12;
the flow sensor 2 calculates the desert cistanche polysaccharide extract amount processed in a single accommodating groove, when the processing amount reaches a set value, the resin filter 6 in the accommodating groove is close to saturation, the controller controls the motor 4 to drive the ring frame 7 to rotate, so that the accommodating groove is replaced by a station, the new resin filter 6 continuously adsorbs, filters and purifies the desert cistanche polysaccharide extract, the nearly saturated resin filter 6 is deviated to one side of the upper part of the mandrel 3, the desert cistanche polysaccharide extract which is not bent and permeated is continuously discharged into the upper liquid cavity 31, the accommodating groove is sequentially transposed, and the nearly saturated resin filter 6 is transferred to the bottommost part of the tank body 1 after all the desert cistanche polysaccharide extract is discharged.
As shown in fig. 2-5, the water washing assembly comprises a liquid discharging cavity 32 and a liquid pump 5, wherein the liquid discharging cavity 32 is arranged at the lower part of the mandrel 3, the liquid pump 5 is arranged outside the tank body 1, the water discharging end of the liquid pump 5 is connected with one end of the liquid discharging cavity 32, and the bottom of the tank body 1 is provided with a waste discharge port 51;
because the resin filter 6 permeates the cistanche polysaccharide extract, the concentration of impurities adsorbed on the upper part of the resin filter 6 is maximum, when the saturated resin filter 6 moves to the bottommost part of the tank 1, the resin filter 6 is turned over, the concentration of impurities is at the bottom of the resin filter 6 at the maximum, the accommodating groove penetrates through the lower liquid cavity 32, the liquid pump 5 is used for introducing cleaning water into the lower liquid cavity 32, the cleaning water washes the resin filter 6 through the net surface, impurities adsorbed on the inner part of the resin filter 6 are discharged from the waste discharge port 51 after being desorbed, the saturation state of the resin filter 6 can be greatly reduced, and the cycle use period of the resin filter 6 is prolonged;
the washed resin filter body 6 is deflected to a station, continuously discharges washing water downwards, and then circulates to the top of the tank body 1 to be recycled.
Example two
As shown in fig. 4-7, the bottom of the inner cavity of the tank body 1 extends downwards to form an arc-shaped expansion part, the section of the containing groove is trapezoid-shaped, and the resin filter body 6 is integrally matched with the arc-shaped expansion part;
the resin filter body 6 is provided with at least two split parts, the outside of each split part is encapsulated by a filter screen, and the inside is filled with adsorption resin particles;
when the accommodating groove is not aligned with the arc-shaped expansion part, the split parts are extruded by the inner wall of the tank body 1 and mutually clung to form the whole adapting accommodating groove, and when the accommodating groove is aligned with the arc-shaped expansion part, the split parts are unfolded under the action of elasticity to enable gaps to be formed between the split parts, so that cleaning water washes the independent split parts, and desorption cleaning of the resin filter body 6 is quickened;
the telescopic piece 8 comprises a telescopic pipe 81 and a telescopic rod 82 which are mutually spliced, the telescopic pipe 81 and the telescopic rod 82 are respectively and fixedly connected with split parts at two end parts, the telescopic pipe 81 fixedly penetrates through the split parts near the mandrel 3, the end part of the telescopic rod 82 is provided with a reducing port, the inner end of the telescopic rod 82 is provided with a plunger part 84 which is matched with the reducing port, the surface of the telescopic rod 82 is provided with a through groove 85 which extends axially, and the surface of the telescopic rod 82 is provided with a through hole 83 which penetrates through the through groove 85;
the telescopic pipe 81 and the telescopic rod 82 are in sliding connection to enable each split part to be opened and closed in a straight line, when the accommodating groove is aligned with the arc-shaped expansion part to enable each split part to be unfolded, the through holes 83 align with gaps between the split parts, a part of cleaning water in the lower liquid cavity 32 enters the through grooves 85 through the reducing holes, then enters between the split parts through the through holes 83, the cleaning water conduction speed between each split part is increased, and desorption cleaning of the resin filter 6 is improved.
Example III
A purification method based on the cistanche deserticola polysaccharide acquisition and purification equipment comprises the following specific steps:
A. introducing herba cistanches polysaccharide extract into the upper accommodating tank through the liquid inlet 11, allowing the herba cistanches polysaccharide extract to penetrate downwards through the resin filter body 6 for adsorption purification, and discharging the purified herba cistanches polysaccharide extract from the purification passage;
B. the upper resin filter body 6 is adsorbed and saturated, the ring frame 7 is driven to rotate by the driving device, so that the accommodating groove and the resin filter body 6 are rotated and transposed, and the cistanche deserticola polysaccharide extract is kept to be continuously adsorbed and purified;
C. the saturated resin filter 6 is rotated to the lower portion of the tank 1, and the resin filter 6 is backwashed by the water washing assembly.

Claims (3)

1. A cistanche deserticola polysaccharide obtaining and purifying device, which is characterized by comprising:
the tank body (1), the central part of the tank body (1) is fixedly penetrated by a mandrel (3), and the top of the tank body (1) is penetrated by a liquid inlet (11);
the ring frame (7), the ring frame (7) rotates outside the mandrel (3), the edge of the ring frame (7), the edge and the side wall of the tank body (1) form a plurality of evenly distributed accommodating grooves, resin filter bodies (6) are placed in the accommodating grooves, and one end of the accommodating grooves, which is close to the mandrel (3), is a net surface;
a purification passage arranged at the upper part of the mandrel (3);
the driving assembly is used for driving the ring frame (7) to rotate, so that the upper accommodating grooves are alternately aligned with the purification passages, the cistanche deserticola polysaccharide extracting solution enters the accommodating grooves at the upper part from the liquid inlet (11), and the cistanche deserticola polysaccharide extracting solution penetrates the resin filter body (6) from top to bottom and is discharged from the purification passages;
the water washing assembly is arranged at the lower part of the mandrel (3) and used for washing the resin filter body (6) in the lower accommodating groove;
the purification passage comprises an upper liquid cavity (31), the upper liquid cavity (31) is arranged at the upper part of the mandrel (3), a net surface is arranged at the upper part of the surface of the mandrel (3) and used for penetrating through the containing groove and the upper liquid cavity (31), and one end of the upper liquid cavity (31) is connected with the liquid outlet (12);
the water washing assembly comprises a lower liquid cavity (32) and a liquid pump (5), the lower liquid cavity (32) is arranged at the lower part of the mandrel (3), a net surface is arranged at the lower part of the surface of the mandrel (3) and used for penetrating through the accommodating groove and the lower liquid cavity (32), the drainage end of the liquid pump (5) is connected with the lower liquid cavity (32), and a waste discharge port (51) is formed in the bottom of the tank body (1);
the inner cavity of the tank body (1) is disc-shaped, the bottom of the inner cavity of the tank body (1) extends to form an arc-shaped expansion part, the resin filter body (6) is at least provided with two split parts, the split parts are connected through a spring, and the accommodating groove is aligned with the arc-shaped expansion part to enable the split parts of the resin filter body (6) to be unfolded;
the section of the accommodating groove is trapezoid, and the split part of the resin filter body (6) is closed and matched with the accommodating groove;
the split parts of the resin filter body (6) are connected through a telescopic piece (8), the telescopic piece (8) comprises a telescopic pipe (81) and a telescopic rod (82) which are mutually spliced, and the telescopic pipe (81) and the telescopic rod (82) are respectively and fixedly connected with the split parts at two ends;
the telescopic pipe (81) is fixedly penetrated through a split part close to the position of the mandrel (3), a diameter reducing opening is formed in the end part of the telescopic rod (82), a plunger part (84) which is matched with the diameter reducing opening is arranged at the inner end of the telescopic rod (82), an axially extending through groove (85) is formed in the surface of the telescopic rod (82), a through hole (83) penetrating through the through groove (85) is formed in the surface of the telescopic rod (82), and the through hole (83) is aligned with a gap between the split parts when the split part is unfolded.
2. The cistanche deserticola polysaccharide acquisition and purification device according to claim 1, wherein the driving component comprises a motor (4), the motor (4) is connected with the ring frame (7) through gear transmission, a flow sensor (2) is arranged in the liquid inlet (11), and the flow sensor (2) and the motor (4) are connected with a controller together.
3. A purification method based on the cistanche deserticola polysaccharide acquisition and purification equipment as claimed in any one of claims 1-2, characterized by the following specific steps:
A. introducing herba cistanches polysaccharide extract into the accommodating groove at the upper part through the liquid inlet (11), allowing the herba cistanches polysaccharide extract to penetrate the resin filter body (6) downwards for adsorption and purification, and discharging the purified herba cistanches polysaccharide extract from the purification passage;
B. the upper resin filter body (6) is adsorbed and saturated, the ring frame (7) is driven to rotate by the driving component, so that the accommodating groove and the resin filter body (6) are rotated and transposed, and the cistanche deserticola polysaccharide extract is kept to be continuously adsorbed and purified;
C. the saturated resin filter body (6) is rotated to the lower part of the tank body (1), and the resin filter body (6) is reversely washed by the water washing assembly.
CN202310554539.0A 2023-05-17 2023-05-17 Cistanche deserticola polysaccharide obtaining and purifying equipment and method Active CN116531802B (en)

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CN117123024B (en) * 2023-08-31 2024-07-05 广州广钢气体能源股份有限公司 Helium purifying equipment and purifying method

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CN114053825A (en) * 2021-11-17 2022-02-18 王云艳 Molecular sieve adsorber
CN114684966A (en) * 2022-04-02 2022-07-01 浙江晶立捷环境科技有限公司 Resource system and method for rosemary lipid solubility extraction wastewater
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