CN116510061A - Preparation method of surgical suture - Google Patents
Preparation method of surgical suture Download PDFInfo
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- CN116510061A CN116510061A CN202310535028.4A CN202310535028A CN116510061A CN 116510061 A CN116510061 A CN 116510061A CN 202310535028 A CN202310535028 A CN 202310535028A CN 116510061 A CN116510061 A CN 116510061A
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- 238000002360 preparation method Methods 0.000 title abstract description 18
- 239000000835 fiber Substances 0.000 claims abstract description 28
- 229920001169 thermoplastic Polymers 0.000 claims abstract description 25
- 239000004416 thermosoftening plastic Substances 0.000 claims abstract description 25
- 239000002994 raw material Substances 0.000 claims abstract description 19
- 239000012530 fluid Substances 0.000 claims abstract description 17
- 238000007493 shaping process Methods 0.000 claims abstract description 14
- 239000000463 material Substances 0.000 claims abstract description 13
- 239000004626 polylactic acid Substances 0.000 claims description 31
- 229920000642 polymer Polymers 0.000 claims description 31
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 30
- 229920001610 polycaprolactone Polymers 0.000 claims description 30
- 239000011159 matrix material Substances 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 21
- 239000006057 Non-nutritive feed additive Substances 0.000 claims description 17
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 4
- 239000001569 carbon dioxide Substances 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 101000691618 Homo sapiens Inactive phospholipase C-like protein 1 Proteins 0.000 claims 2
- 102100026207 Inactive phospholipase C-like protein 1 Human genes 0.000 claims 2
- 229920000848 poly(L-lactide-ε-caprolactone) Polymers 0.000 claims 2
- 239000007858 starting material Substances 0.000 claims 1
- 239000004632 polycaprolactone Substances 0.000 description 29
- 239000000126 substance Substances 0.000 description 20
- 230000000052 comparative effect Effects 0.000 description 19
- 238000004519 manufacturing process Methods 0.000 description 9
- 238000002425 crystallisation Methods 0.000 description 5
- 230000008025 crystallization Effects 0.000 description 5
- 229920002521 macromolecule Polymers 0.000 description 4
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- 210000001519 tissue Anatomy 0.000 description 3
- 241001494479 Pecora Species 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
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- 238000011056 performance test Methods 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000032544 Cicatrix Diseases 0.000 description 1
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- 230000001737 promoting effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to the technical field of biomedical new materials, and particularly discloses a preparation method of a medical surgical suture, which comprises the following steps: s1: the raw materials for preparing the surgical suture are melted and blended and then subjected to hot stretching to obtain nascent fiber; s2: carrying out cold stretching treatment on the unfixed nascent fiber yarn along the fiber orientation direction, so that the diameter of the nascent fiber yarn after cold stretching meets the diameter specification of the surgical suture, and then removing the stretching load to obtain a filament yarn; s3: fixing the two ends of the filament by adopting a clamping piece, and then carrying out thermoplastic shaping treatment on the filament under the protection of supercritical fluid to obtain the single-strand surgical suture. The surgical suture prepared by the invention has good mechanical property, tissue compatibility and biodegradability, can meet the requirements of consumers on the degradable suture, and has wide market prospect.
Description
Technical Field
The invention relates to the technical field of biomedical new materials, in particular to a preparation method of a surgical suture line.
Background
Medical surgical sutures are indispensable medical materials for suturing wounds after surgery. Surgical threads typically include both soluble and insoluble components. Non-biodegradable sutures cannot be absorbed by the body, have different degrees of tissue reaction, and scar the sutured epidermis, especially local skin; the biodegradable suture is easy to be absorbed or excreted after being degraded in body tissues, so that the pain of a patient caused by secondary operation is avoided, the infection chance of wounds is reduced, and the scars are small. Therefore, biodegradable medical sutures are attracting more and more attention.
The equipment price of hot spinning is high, the processing process is complex, and technicians with more experience are required to operate the equipment, so that the cost is high; corresponding production processes often produce only one diameter suture. Modifying the process to produce sutures of different wire diameters is not suitable for such production facilities. The suture used in the operation has a large size from a thick suture to a thin suture. The suture lines with different diameters can be produced by adopting a simple device, which is the direction of modern production technology innovation.
Disclosure of Invention
Aiming at the problems and the defects existing in the prior art, the invention aims to provide a preparation method of a surgical suture.
In order to achieve the aim of the invention, the technical scheme adopted by the invention is as follows:
the first aspect of the invention provides a method for preparing a single strand surgical suture, comprising the steps of:
s1: the raw materials for preparing the surgical suture are melted and blended and then subjected to hot stretching to obtain nascent fiber;
s2: according to the diameter specification of the prepared surgical suture, carrying out cold stretching treatment on the nascent fiber yarn along the fiber orientation direction, so that the diameter of the nascent fiber yarn after cold stretching meets the diameter specification of the surgical suture, and then removing the stretching load to obtain a filament;
s3: fixing the two ends of the filament by adopting a clamping piece, and then carrying out thermoplastic shaping treatment on the filament under the protection of supercritical fluid to obtain the single-strand surgical suture.
According to the above preparation method, preferably, in step S3, the thermoplastic shaping temperature is 25-45 ℃ for 24 hours.
According to the above preparation method, preferably, in step S3, the supercritical fluid is carbon dioxide or/and nitrogen; the supercritical fluid has a pressure of 10-17 MPa. More preferably, the supercritical fluid is carbon dioxide.
According to the above preparation method, preferably, in step S1, the temperature of melt blending is 70 to 200 ℃; the temperature of the hot stretching is 70-200 ℃.
According to the above-mentioned production method, preferably, in step S2, the temperature of the cold stretching treatment is 15 to 25 ℃. More preferably, the temperature of the cold stretching treatment is 25 ℃.
According to the above-mentioned production method, preferably, in step S2, the drawing ratio of the cold drawing treatment is 1.2 to 3 and the drawing rate is 1 to 5mm/min. More preferably, the stretching rate is 1mm/min.
According to the above preparation method, preferably, the raw material comprises a polymer matrix, and the polymer matrix is PCL (polycaprolactone), polylactic acid or PLCL (poly L-lactide-caprolactone).
According to the above preparation method, preferably, the raw material further comprises a fiber-forming phase substance, wherein the fiber-forming phase substance accounts for 5% -40% of the total weight of the polymer matrix. More preferably, the fiber-forming phase material comprises 20% to 30% of the total weight of the polymer matrix.
According to the above preparation method, preferably, the raw materials further comprise a processing aid, wherein the processing aid accounts for 1-10% of the total weight of the polymer matrix. More preferably, the processing aid comprises 3 to 5% by weight of the total polymer matrix.
According to the above-mentioned production method, preferably, the fiber-forming phase substance is polylactic acid; the processing aid is PLCL.
According to the above preparation method, preferably, the raw material is composed of a polymer matrix and a fiber-forming phase substance, wherein the polymer matrix is PLCL, and the fiber-forming phase substance is polylactic acid; the polylactic acid accounts for 40% of the total weight of the PLCL.
According to the above preparation method, preferably, the raw material is composed of a polymer matrix and a fiber-forming phase substance, wherein the polymer matrix is PCL, and the fiber-forming phase substance is polylactic acid; the polylactic acid accounts for 20% of the total weight of the PCL.
According to the above-mentioned production method, preferably, the raw material is composed of a polymer matrix, a fiber-forming phase substance and a processing aid; more preferably, the polymer matrix is PCL, the fiber-forming phase material is polylactic acid, and the processing aid is PLCL; the polylactic acid accounts for 20% of the total weight of the PCL, and the PLCL accounts for 5% of the total weight of the PCL.
According to the above-described production method, preferably, in step S3, the distance between the two holders is 1.01 to 1.2 times the original length of the filament in that direction. More preferably, the distance between the two clamps is 1.1 times the original length of the filament in that direction.
According to the above preparation method, preferably, the melt blending is performed in step S1 by using a twin-screw extruder having a screw speed of 90 to 110rpm.
According to the above preparation method, preferably, in step S1, the hot stretching is performed by using a high-speed roller, and the angular velocity of the high-speed roller is 90 to 110rad/min.
In a second aspect, the present invention provides a surgical suture prepared by the method of the first aspect.
Compared with the prior art, the invention has the following positive and beneficial effects:
(1) The polymer raw material is subjected to melt blending extrusion and hot stretching to prepare the nascent fiber yarn, and then the nascent fiber yarn is subjected to cold stretching of 1.2-3 times under the condition of room temperature, so that the cold stretching can not only improve the orientation of macromolecules in the suture line, but also further perfect the structure of a crystal area, induce the orientation crystallization of macromolecules and improve the mechanical property of the suture line; therefore, the drawn yarn with mechanical properties (ultimate tensile stress, elongation at break and elastic modulus) superior to those of the existing commercial single-strand medical surgical suture can be obtained through two-time drawing treatment.
(2) The invention carries out thermoplastic shaping on filaments after cold drawing and drafting under the protection of supercritical carbon dioxide fluid, and passes through supercritical CO 2 The introduction of the polymer can reduce the hydrogen bonding degree of the macromolecular material in the filament, induce the macromolecular material to crystallize, further improve the crystallinity of the macromolecular material and strengthen the tensile strength of the suture lineA degree; moreover, thermoplastic shaping can enable the polymer molecules to be converted from an unbalanced conformation to a balanced conformation, thereby eliminating internal stress and improving the dimensional stability of the suture.
(3) The preparation surgical suture line of the invention takes a polymer matrix, a fiber-forming phase substance and a processing aid as raw materials, and in the process of melt extrusion hot stretching, the fiber-forming phase substance is stretched in situ, and nanofibers with larger length-diameter ratio are formed in polymer nascent fiber filaments, so that the orientation degree of the nascent fiber filaments is increased, macromolecules are orderly arranged along the axial direction due to the increase of the orientation degree, and the intermolecular acting force is large, so that the strength is correspondingly increased; the processing aid can play a role in compatibilization, improve the phase interface between the polymer matrix and the fiber-forming phase substance, and further improve the mechanical strength of the surgical suture.
More preferably, the invention utilizes the advantage complementation of the composite material, takes PCL (polycaprolactone) as a polymer matrix, and adds a fiber-forming phase substance polylactic acid (PLA) into the PCL (polycaprolactone) to improve the crystallinity and mechanical property of the PCL material; in addition, the PLCL is used as a processing aid, and the PLCL is used as a copolymer of the PCL and the PLA, so that the PLCL has a good compatibilization effect, the phase interface between the PCL and the PLA is improved, and the mechanical strength is further improved. Therefore, the invention forms an effect of complementary advantages by blending the PCL, PLA, PLCL materials, not only exerts the characteristics of good plasticity, flexibility and the like of PCL, but also exerts the advantage of high PLA strength, and the prepared surgical suture has good mechanical property, tissue compatibility and biodegradability, can meet the requirements of consumers on the degradable suture, and has wide market prospect.
(4) According to the preparation method of the surgical suture, by adjusting the stretching multiplying power of hot stretching and cold stretching, surgical suture products with different diameters and length specifications can be prepared, so that the requirements of sutures with different diameters are met; moreover, the processing equipment of the medical surgical suture line is simple, the price is economical, the process is simple and flexible, and the suture lines with different diameters can be produced on the same machine without changing the preparation process; low production energy consumption.
(5) The degradable suture thread prepared by the invention belongs to the biomedical textile, is the leading field of the textile field, has the characteristics of high-tech content, high added value and the like, and has important significance for promoting the industrial upgrading of the local traditional textile industry and the enterprise revenue generation.
Drawings
FIG. 1 is a schematic flow chart of a method of preparing a single strand surgical suture of the present invention;
FIG. 2 is a graph showing the results of diameter measurement of the surgical suture prepared in example 1 of the present invention;
FIG. 3 is a crystalline state diagram of a single strand surgical suture of the present invention during a supercritical fluid thermoplastic sizing process.
Detailed Description
It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
The experimental methods in the following examples, in which specific conditions are not specified, are all conventional in the art or according to the conditions suggested by the manufacturer; the reagents or apparatus used were conventional products commercially available without the manufacturer's attention.
The present invention will be further described in detail by way of specific examples, which do not limit the scope of the present invention, so that those skilled in the art can more clearly understand the technical aspects of the present invention.
Example 1:
a method for processing a single strand surgical suture (as shown in fig. 1), comprising the steps of:
s1: the raw materials for preparing the surgical suture are dried and then mixed uniformly, and melt blending is carried out by a double-screw extruder; the temperature of the twin-screw extruder from the barrel to the die was set at 170℃at 190℃at 190℃and 180℃in this order, and the rotational speed of the twin-screw extruder was 80rpm. After the blend is discharged from the die of the double-screw extruder, the high-speed roller is adopted for hot stretching to obtain primary fiber, and the primary fiber is wound and collected on the roller after being cooled in a water bath. During the hot stretching, the rotating speed of the high-speed roller is 90rad/min; the temperature of the hot stretching was 180 ℃.
The raw materials comprise a polymer matrix, a fiber-forming phase substance and a processing aid, wherein the polymer matrix is PCL, the fiber-forming phase substance is PLA, and the processing aid is PLCL; PLA constituted 20% of the total PCL and PLCL constituted 5% of the total PCL.
S2: according to the diameter specification of the prepared surgical suture, cold stretching treatment is carried out on the nascent fiber yarn by adopting a universal stretcher along the fiber orientation direction under the condition of room temperature, so that the diameter of the nascent fiber yarn after cold stretching meets the diameter specification standard of the surgical suture 7-0, and then the stretching load is removed, so as to obtain the filament yarn. The stretching ratio of the cold stretching treatment is 1.2-3, and the stretching speed is 1mm/min.
S3: fixing the two ends of the filament with clamping members (the distance between the two clamping members is 1.1 times the original length of the filament in the direction), and then performing supercritical fluid CO 2 And carrying out thermoplastic setting treatment on the filaments under protection to obtain a single-strand surgical suture (the specification of the surgical suture is 7-0). Wherein the supercritical fluid CO 2 The pressure of the thermoplastic shaping is 10-17 MPa, the temperature of the thermoplastic shaping is 30 ℃ and the time is 24 hours.
FIG. 2 is a graph showing the results of diameter measurement of the surgical suture prepared in example 1 of the present invention. As can be seen from FIG. 2, the surgical suture prepared according to the present invention has a diameter of 0.066mm, and the diameter specification meets the "7-0" surgical suture standard prescribed by the United states pharmacopoeia Commission USP.
Example 2:
the content of example 2 is substantially the same as that of example 1, except that:
in step S1: the raw materials consist of a polymer matrix and a fiber-forming phase substance, wherein the polymer matrix is PCL, and the fiber-forming phase substance is PLA; PLA constituted 20% of the total PCL weight.
Example 3:
the content of example 3 is substantially the same as that of example 1, except that:
in step S1: the temperature of the twin-screw extruder from the charging barrel to the die is set to be 80 ℃, 85 ℃ and 75 ℃ in sequence, and the rotating speed of the twin-screw extruder is 90rpm; during hot stretching, the rotating speed of the roller is 110rad/min; the temperature of the hot stretching is 75 ℃; the raw material is PCL.
Example 4:
the content of example 4 is substantially the same as that of example 1, except that:
in step S1: the rotational speed of the twin-screw extruder was 90rpm; the rotational speed of the drum during hot stretching was 100rad/min. The raw materials consist of a polymer matrix and a fiber-forming phase substance, wherein the polymer matrix is PLCL, and the fiber-forming phase substance is PLA; PLA accounted for 40% of the total weight of PLCL.
Example 5:
the content of example 5 is substantially the same as that of example 1, except that:
in step S1: the rotational speed of the twin-screw extruder was 90rpm; the rotational speed of the drum during hot stretching was 110rad/min. The raw material is PLA.
In step S3: the thermoplastic setting temperature is 65 ℃.
Example 6:
the content of example 6 is substantially the same as that of example 1, except that:
in step S3: the thermoplastic setting temperature was 45 ℃.
Example 7:
the content of example 7 is substantially the same as that of example 1, except that:
in step S3: the thermoplastic setting temperature was 40 ℃.
Example 8:
the content of example 8 is substantially the same as that of example 1, except that:
in step S2: the temperature of the cold stretching treatment is 20 ℃, and the stretching rate of the cold stretching treatment is 5mm/min;
in step S3: the thermoplastic setting temperature was 40 ℃.
Example 9:
the content of example 9 is substantially the same as that of example 3, except that:
in step S2: the temperature of the cold stretching treatment is 15 ℃, and the stretching rate of the cold stretching treatment is 3mm/min;
in step S3: the thermoplastic setting temperature was 25 ℃.
The performance of the single-strand surgical sutures prepared in examples 1 to 5 of the present invention was tested, and comparative experiments, comparative examples 1 to 5, were performed in order to verify the effect of the thermoplastic setting treatment under the protection of the supercritical fluid on the performance of the surgical sutures. The contents of comparative examples 1 to 5 are substantially the same as those of examples 1 to 5, except that: comparative examples 1 to 5 filaments obtained after cold stretching treatment were single strand surgical sutures, and the operation of step S3 was not performed (i.e., no supercritical fluid CO was used) 2 And carrying out thermoplastic shaping treatment on the filaments under protection). The performance test of the single-strand surgical suture prepared in examples 1 to 5 and comparative examples 1 to 5 was performed while comparing with the existing commercial single-strand sheep intestine suture (comparative example 6), and the results are shown in table 1.
Table 1 results of performance tests of surgical sutures prepared in examples 1 to 5
As can be seen from Table 1, comparing the examples with the comparative examples, the supercritical CO is passed 2 And (3) performing thermoplastic setting in the atmosphere, wherein the ultimate tensile stress and the elastic modulus of the suture line are improved, and the elongation at break is slightly reduced. Comparing example 5 with example 3, it can be seen that PLA has a higher ultimate tensile stress and modulus of elasticity, but a lower elongation at break. Blending PLA with PCL in situ to form a fiber (example 2 and comparative example 2), PLA is charged therein as a fiber phase, and can increase the ultimate tensile stress and elastic modulus of the suture (example 3 and comparative example 3). The addition of PLCL can increase the elongation at break of PLA (examples 4 and 5). The PLCL is further added into the PCL/PLA as a processing aid, so that the PLCL can play a good role in compatibilization, the phase interface between the PCL and the PLA is improved, and the PCL/PLA is further improvedThe ultimate tensile stress was high (examples 1 and 2). Finally, example 1, as an optimal component, has a higher ultimate tensile stress on the basis of a similar modulus of elasticity and elongation at break, compared to the comparative 6 commercial sheep intestine suture.
In order to verify the influence of cold stretching treatment on the crystallinity of the surgical suture, the invention takes the single-strand surgical suture prepared in the example 1 as an example, and researches the crystallization state of the surgical suture under different treatment time of supercritical fluid thermoplastic shaping; meanwhile, comparative example 7 in which cold stretching treatment was not performed was also set in the present invention.
The contents of comparative example 7 are as follows:
a method for processing a single strand surgical suture, comprising the steps of:
s1: the raw materials for preparing the surgical suture are dried and then mixed uniformly, and melt blending is carried out by a double-screw extruder; the temperature of the twin-screw extruder from the barrel to the die was set at 170℃at 190℃at 190℃and 180℃in this order, and the rotational speed of the twin-screw extruder was 80rpm. After the blend is discharged from the die of the double-screw extruder, the high-speed roller is adopted for hot stretching, so as to obtain the primary fiber yarn with the diameter specification meeting the 7-0 standard of the surgical suture line, and the primary fiber yarn is wound and collected on the roller after being cooled in a water bath. During the hot stretching, the rotating speed of the roller is 90rad/min; the temperature of the hot stretching was 180 ℃.
The raw materials comprise a polymer matrix, a fiber-forming phase substance and a processing aid, wherein the polymer matrix is PCL, the fiber-forming phase substance is PLA, and the processing aid is PLCL; PLA constituted 20% of the total PCL and PLCL constituted 5% of the total PCL.
S2: fixing the two ends of the nascent fiber yarn with clamping members (the distance between the two clamping members is 1.1 times of the original length of the yarn in the direction), and then performing supercritical fluid CO 2 And carrying out thermoplastic shaping treatment on the filaments under protection to obtain the single-strand surgical suture. Wherein the thermoplastic shaping temperature is 30 ℃ and the time is 24 hours.
The crystallization state diagram of the single strand surgical suture prepared in example 1 and comparative example 7 during the supercritical fluid thermoplastic setting treatment is shown in fig. 3.
As can be seen from fig. 3, in example 1, compared with comparative example 7, macromolecules in the suture line are oriented after cold stretching treatment, and oriented crystallization is induced; moreover, with supercritical CO 2 And the thermoplastic shaping treatment time is prolonged under the atmosphere, and the crystallinity is obviously improved. Thus, the cold stretching treatment can induce macromolecular orientation crystallization in the suture line, and supercritical CO 2 The thermoplastic shaping treatment can further improve the crystallinity of the macromolecular material, thereby enhancing the tensile strength of the suture line.
The mechanical properties of the single-strand surgical sutures prepared in example 1 and comparative example 7 are compared to each other as shown in table 2.
Table 2 results of mechanical property comparison of single-strand surgical sutures prepared in example 1 and comparative example 7
As can be seen from Table 2, the ultimate tensile stress of example 1 was increased by 6 times or more, the elastic modulus was increased by 4 times and the elongation at break was reduced by 7 times as compared with comparative example 7 under the same specification after the cold drawing treatment
In order to verify the influence of cold stretching treatment on the mechanical properties of surgical suture, the method for preparing single-strand surgical suture described in comparative example 5 is taken as an example, and the ultimate tensile stress of filaments obtained after hot stretching and cold stretching treatment in comparative example 5 and the ultimate tensile stress of nascent fiber filaments obtained only after hot stretching treatment are respectively detected. The ultimate tensile stress of the filament obtained after hot stretching and cold stretching treatment can reach 400.02MPa, but the ultimate tensile stress of the nascent fiber obtained after hot stretching treatment only is 53.06MPa. This demonstrates that the cold stretching treatment can greatly improve the mechanical properties of the surgical suture.
The above-described embodiments are provided to illustrate the gist of the present invention, but are not intended to limit the scope of the present invention. It will be understood by those skilled in the art that various modifications and equivalent substitutions may be made to the technical solution of the present invention without departing from the spirit and scope of the technical solution of the present invention.
Claims (10)
1. A method for preparing a single strand surgical suture, comprising the steps of:
s1: the raw materials for preparing the surgical suture are melted and blended and then subjected to hot stretching to obtain nascent fiber;
s2: carrying out cold stretching treatment on the nascent fiber yarn along the fiber orientation direction, so that the diameter of the nascent fiber yarn after cold stretching meets the diameter specification of the surgical suture, and then removing the stretching load to obtain a filament yarn;
s3: fixing the two ends of the filament by adopting a clamping piece, and then carrying out thermoplastic shaping treatment on the filament under the protection of supercritical fluid to obtain the single-strand surgical suture.
2. The method according to claim 1, wherein in step S3, the thermoplastic setting temperature is 25 to 45 ℃ for 24 hours.
3. The method according to claim 2, wherein in step S3, the supercritical fluid is carbon dioxide or/and nitrogen, and the pressure of the supercritical fluid is 10 to 17MPa.
4. A method according to any one of claims 1 to 3, wherein in step S1, the temperature of melt blending is 70 to 200 ℃; the temperature of the hot stretching is 70-200 ℃.
5. The method according to claim 4, wherein in the step S2, the temperature of the cold stretching treatment is 15 to 25 ℃; the stretching ratio of the cold stretching treatment is 1.2-3, and the stretching rate is 1-5 mm/min.
6. The method of claim 5, wherein the starting material comprises a polymer matrix, and wherein the polymer matrix is PCL, polylactic acid, or PLCL.
7. The method of claim 6, wherein the feedstock further comprises a fiber-forming phase material, the fiber-forming phase material comprising from 5% to 40% of the total weight of the polymer matrix.
8. The method of claim 7, wherein the feedstock further comprises a processing aid, the processing aid comprising 1 to 10% by weight of the total polymer matrix.
9. The method of claim 8, wherein the fiber-forming phase material is polylactic acid; the processing aid is PLCL.
10. A surgical suture prepared by the method of any one of claims 1 to 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310535028.4A CN116510061A (en) | 2023-05-12 | 2023-05-12 | Preparation method of surgical suture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310535028.4A CN116510061A (en) | 2023-05-12 | 2023-05-12 | Preparation method of surgical suture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116510061A true CN116510061A (en) | 2023-08-01 |
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