CN116392530A - 一种治疗风湿的中药组合物及制备方法 - Google Patents
一种治疗风湿的中药组合物及制备方法 Download PDFInfo
- Publication number
- CN116392530A CN116392530A CN202310285950.2A CN202310285950A CN116392530A CN 116392530 A CN116392530 A CN 116392530A CN 202310285950 A CN202310285950 A CN 202310285950A CN 116392530 A CN116392530 A CN 116392530A
- Authority
- CN
- China
- Prior art keywords
- parts
- traditional chinese
- radix
- chinese medicine
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 74
- 239000000203 mixture Substances 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 210000000582 semen Anatomy 0.000 claims abstract description 19
- 241000903946 Clematidis Species 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 12
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 9
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 9
- 241000096284 Gynochthodes officinalis Species 0.000 claims abstract description 9
- 244000291333 Serissa japonica Species 0.000 claims abstract description 9
- 235000017803 cinnamon Nutrition 0.000 claims abstract description 9
- 241000173529 Aconitum napellus Species 0.000 claims abstract description 8
- 241000382455 Angelica sinensis Species 0.000 claims abstract description 8
- 241000045403 Astragalus propinquus Species 0.000 claims abstract description 8
- 241000007126 Codonopsis pilosula Species 0.000 claims abstract description 8
- 229940023019 aconite Drugs 0.000 claims abstract description 8
- 235000006533 astragalus Nutrition 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 238000010298 pulverizing process Methods 0.000 claims description 17
- 239000000843 powder Substances 0.000 claims description 16
- 238000010438 heat treatment Methods 0.000 claims description 15
- 238000000605 extraction Methods 0.000 claims description 14
- 241000756943 Codonopsis Species 0.000 claims description 11
- 239000009636 Huang Qi Substances 0.000 claims description 11
- 239000010271 massa medicata fermentata Substances 0.000 claims description 11
- 238000001035 drying Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 238000002791 soaking Methods 0.000 claims description 9
- 241000723347 Cinnamomum Species 0.000 claims description 8
- 238000007873 sieving Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 7
- 239000008213 purified water Substances 0.000 claims description 7
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 238000007710 freezing Methods 0.000 claims description 6
- 230000008014 freezing Effects 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 230000005855 radiation Effects 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 15
- 239000000284 extract Substances 0.000 abstract description 11
- 239000004480 active ingredient Substances 0.000 abstract description 9
- 230000001225 therapeutic effect Effects 0.000 abstract description 7
- 208000025747 Rheumatic disease Diseases 0.000 abstract description 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 2
- 244000223760 Cinnamomum zeylanicum Species 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 17
- 230000000052 comparative effect Effects 0.000 description 11
- 241000699670 Mus sp. Species 0.000 description 8
- 238000004806 packaging method and process Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000002708 enhancing effect Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- 241000208340 Araliaceae Species 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000004043 dyeing Methods 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 244000036978 Caesalpinia bonduc Species 0.000 description 1
- 235000014145 Caesalpinia bonduc Nutrition 0.000 description 1
- 235000016513 Caesalpinia crista Nutrition 0.000 description 1
- 241000218158 Clematis Species 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000016285 Movement disease Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003435 antirheumatic agent Substances 0.000 description 1
- 229940107666 astragalus root Drugs 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229960001259 diclofenac Drugs 0.000 description 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 208000035474 group of disease Diseases 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 231100000234 hepatic damage Toxicity 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000001503 joint Anatomy 0.000 description 1
- 230000008407 joint function Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 229960000681 leflunomide Drugs 0.000 description 1
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 description 1
- 230000008818 liver damage Effects 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
- 229960001940 sulfasalazine Drugs 0.000 description 1
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及中药技术领域,尤其是涉及一种治疗风湿的中药组合物及制备方法。该中药组合物包括以下重量份的原料:威灵仙10‑12份、肉桂10‑12份、六月雪10‑12份、巴戟天12‑15份、桂枝8‑10份、云实15‑20份、附子8‑13份、当归9‑14份、黄芪25‑28份、党参15‑17份、六神曲15‑17份。该组合物治疗风湿性疾病效果显著,不易复发。本发明还提供了该中药组合物的制备方法,能够充分提取药物的有效成分,保护药物中的有效成分和活性不被破坏,提高人体吸收率,增强治疗效果。
Description
技术领域
本发明涉及中药技术领域,尤其是涉及一种治疗风湿的中药组合物及制备方法。
背景技术
风湿病是一组侵犯关节、骨骼、肌肉、血管及有关软组织或***为主的疾病,其中多数为自身免疫性疾病。发病多较隐蔽而缓慢,患病因素包括感染、免***缺陷、遗传,病程较长,需要长期接受治疗,且大多具有遗传倾向。
现有的许多抗风湿药物,比如非甾体抗炎药(如阿司匹林、布洛芬、双氯芬酸)、免疫抑制剂(如甲氨蝶呤、来氟米特、柳氮磺胺吡啶)及部分生物制剂等都可以引起药物性肝损,同时服药时间长,有的患者可能需要终身服药,治疗效果并不理想。
中药是以中国传统医药理论指导采集、炮制、制剂,说明作用机理,指导临床应用的药物,用于预防、治疗、诊断疾病并具有康复与保健作用的物质。中药主要来源于天然药及其加工品,包括植物药、动物药、矿物药类药物,长期食用对身体无损害,但是现有的中药配方治疗风湿的效果并不显著,易复发,而且其制备方法过程中不能很好的保留药物的有效成分,不能发挥药物的最大作用。
鉴于此,需要一种不易复发的中药组合物用于治疗风湿,同时也需要一种能够最大程度地保留药物中有效成分的制备方法。
发明内容
本发明的第一目的在于提供一种治疗风湿的中药组合物,该组合物治疗风湿性疾病效果显著,不易复发。本发明的第二目的在于提供一种治疗风湿的中药组合物的制备方法,该方法能够充分提取药物的有效成分。
本发明提供的一种治疗风湿的中药组合物,包括以下重量份的原料:威灵仙10-12份、肉桂10-12份、六月雪10-12份、巴戟天12-15份、桂枝8-10份、云实15-20份、附子8-13份、当归9-14份、黄芪25-28份、党参15-17份、六神曲15-17份。
优选地,包括以下重量份的原料:威灵仙10份、肉桂10份、六月雪10份、巴戟天12份、桂枝8份、云实15份、附子8份、当归10份、黄芪25份、党参15份、六神曲17份。
本发明提供的上述中药组合物的制备方法,将上述所有原料加工制成中药制剂。
优选地,所述中药制剂为散剂、丸剂、膏剂、口服液或药酒。
优选地,所述中药制剂为散剂。
优选地,包括以下步骤:
(1)将云实、附子、当归、黄芪、党参、六神曲粉碎后,加入纯净水浸泡后煎煮,煎煮后获得第一提取液;
(2)将威灵仙、肉桂、六月雪、巴戟天、桂枝粉碎后加入超声逆流提取设备中,加入提取溶剂乙醇,提取后,过滤,滤液减压浓缩,得到第二提取液;
(3)将第一提取液和第二提取液混合,减压浓缩,真空冷冻干燥,粉碎,过筛,灭菌,得到中药散剂。
优选地,所述步骤(1)中浸泡时间为20-24小时,加水煎煮两次,每次煎煮加入药材重量2-3倍的水,在95-100℃的条件下煎煮3-4小时;更优选地,所述步骤(1)中浸泡时间为24小时,加水煎煮两次,每次煎煮加入药材重量3倍的水,在100℃的条件下煎煮3.5小时。采用煎煮的方法相比较采用回流法更能充分地提取出上述药物中的有效成分,重复两次煎煮能够保证各有效成分被富集,增强治疗效果。
优选地,所述步骤(2)中加入乙醇的重量为药材重量的8-10倍,超声频率设置为30-50kHz,温度为45-50℃,提取时间为4-5小时。更优选地,所述步骤(2)中加入乙醇的重量为药材重量的10倍,超声频率设置为50kHz,温度为50℃,提取时间为5小时。采用超声波提取比水煎煮法提取的药物的要有效成分更全面,治疗效果更好。
优选地,所述步骤(3)中的真空冷冻干燥具体过程为:在0.1Pa-0.3Pa真空度下,先在-25℃--30℃下冷冻7-8h,然后以每分钟1-2℃的速度缓慢升温,至0-5℃下干燥3-4h,再以每分钟1-2℃的速度继续缓慢升温,至25-30℃下干燥14-15h。更优选地,所述步骤(3)中的真空冷冻干燥具体过程为:在0.1Pa真空度下,先在-30℃下冷冻7h,然后以每分钟1℃的速度缓慢升温,至2℃下干燥3h,再以每分钟1℃的速度继续缓慢升温,至30℃下干燥14h。采用真空冷冻干燥比采用加热烘干能更好的保护中原料中的有效成分和活性物质,增强治疗效果。采用上述逐级升温干燥能够防止药物内部也充分干燥,粉碎后在水中易溶解,易于人体吸收。
优选地,所述步骤(3)中过筛采用80-100目筛;灭菌采用紫外线辐射处理40-50分钟。
综上所述,本发明与现有技术相比具有以下优点:
本发明提供的中药组合物采用威灵仙、肉桂、六月雪、巴戟天、桂枝为君药,散风祛湿,舒筋活络,温经通脉;云实、附子和当归为臣药,抗菌消炎;黄芪、党参和六神曲为佐药,补中益气,健脾益肺,增强免疫力,提高身体素质;君臣相辅,先消除患处的炎症,再进行温经通脉,治疗效果更明显,与传统治疗风湿的中药相比缩短了治疗时间,佐药配合二者增强身体免疫力,长期服用对身体无损害,不宜复发,适用于风湿痹痛、四肢酸麻、腰膝无力、风湿导致的关节变形等症。
本发明提供的上述中药组合物的制备方法,能够最大程度提取各个药物中的有效成分,使药性发挥到最大,保护药物中的有效成分和活性不被破坏,提高人体吸收率,增强治疗效果。
具体实施方式
应该指出,以下详细说明都是例示性的,旨在对本申请提供进一步的说明。除非另有指明,本文使用的所有技术和科学术语具有与本申请所属技术领域的普通技术人员通常理解的相同含义。
需要注意的是,这里所使用的术语仅是为了描述具体实施方式,而非意图限制根据本申请的示例性实施方式。如在这里所使用的,除非上下文另外明确指出,否则单数形式也包括复数形式,此外,还应当理解的是,当在本说明中使用术语“包含”和/或“包括”时,其指明存在特征、步骤、操作、器件、组件和/或它们的组合。
下面将结合实施例对本发明的技术方案进行清楚、完整地描述,显然,所描述的实施例是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1
一种治疗风湿的中药组合物,由以下重量份的原料组成:威灵仙10份、肉桂10份、六月雪10份、巴戟天12份、桂枝8份、云实15份、附子8份、当归10份、黄芪25份、党参15份、六神曲17份。
将上述中药组合物加工制成中药散剂,具体步骤如下:
(1)将云实、附子、当归、黄芪、党参、六神曲粉碎后,加入纯净水浸泡24小时,加入云实、附子、当归、黄芪、党参、六神曲总重量3倍的水,在100℃的条件下煎煮3.5小时,重复煎煮2次,获得第一提取液;
(2)将威灵仙、肉桂、六月雪、巴戟天、桂枝粉碎后加入超声逆流提取设备中,加入提取溶剂乙醇,加入乙醇的重量为威灵仙、肉桂、六月雪、巴戟天、桂枝总重量的10倍,超声频率设置为50kHz,温度为50℃,提取5小时后过滤,滤液减压浓缩,得到第二提取液;
(3)将第一提取液和第二提取液混合,减压浓缩,真空冷冻干燥,在0.1Pa真空度下,先在-30℃下冷冻7h,然后以每分钟1℃的速度缓慢升温,至2℃下干燥3h,再以每分钟1℃的速度继续缓慢升温,至30℃下干燥14h,干燥后粉碎,过80目筛,紫外线辐射处理50分钟,分装,每袋10克,得到中药散剂。
上述中药散剂使用时直接取一包放入150mL温水中搅拌均匀,一日三次,每次一包,三天为一个疗程,连续服用3个疗程。
实施例2
一种治疗风湿的中药组合物,由以下重量份的原料组成:威灵仙12份、肉桂12份、六月雪12份、巴戟天15份、桂枝10份、云实20份、附子13份、当归14份、黄芪28份、党参17份、六神曲15份。
将上述中药组合物加工制成中药散剂,具体步骤如下:
(1)将云实、附子、当归、黄芪、党参、六神曲粉碎后,加入纯净水浸泡20小时,加入云实、附子、当归、黄芪、党参、六神曲总重量2倍的水,在95℃的条件下煎煮4小时,重复煎煮2次,获得第一提取液;
(2)将威灵仙、肉桂、六月雪、巴戟天、桂枝粉碎后加入超声逆流提取设备中,加入提取溶剂乙醇,加入乙醇的重量为威灵仙、肉桂、六月雪、巴戟天、桂枝总重量的8倍,超声频率设置为30kHz,温度为45℃,提取4小时后过滤,滤液减压浓缩,得到第二提取液;
(3)将第一提取液和第二提取液混合,减压浓缩,真空冷冻干燥,在0.3Pa真空度下,先在-25℃下冷冻8h,然后以每分钟1℃的速度缓慢升温,至5℃下干燥3h,再以每分钟1℃的速度继续缓慢升温,至25℃下干燥15h,干燥后粉碎,过80目筛,紫外线辐射处理45分钟,分装,每袋10克,得到中药散剂。
上述中药散剂使用时直接取一包放入150mL温水中搅拌均匀,一日三次,每次一包,3天为一个疗程,连续服用3个疗程。
实施例3
一种治疗风湿的中药组合物,由以下重量份的原料组成:威灵仙11份、肉桂11份、六月雪11份、巴戟天13份、桂枝9份、云实17份、附子11份、当归12份、黄芪27份、党参16份、六神曲16份。
将上述中药组合物加工制成中药散剂,具体步骤如下:
(1)将云实、附子、当归、黄芪、党参、六神曲粉碎后,加入纯净水浸泡22小时,加入云实、附子、当归、黄芪、党参、六神曲总重量2.5倍的水,在98℃的条件下煎煮3.5小时,重复煎煮2次,获得第一提取液;
(2)将威灵仙、肉桂、六月雪、巴戟天、桂枝粉碎后加入超声逆流提取设备中,加入提取溶剂乙醇,加入乙醇的重量为威灵仙、肉桂、六月雪、巴戟天、桂枝总重量的9倍,超声频率设置为40kHz,温度为47℃,提取4.5小时后过滤,滤液减压浓缩,得到第二提取液;
(3)将第一提取液和第二提取液混合,减压浓缩,真空冷冻干燥,在0.2Pa真空度下,先在-27℃下冷冻7.5h,然后以每分钟1.5℃的速度缓慢升温,至3℃下干燥3.5h,再以每分钟1.5℃的速度继续缓慢升温,至27℃下干燥14.5h,干燥后粉碎,过100目筛,紫外线辐射处理40分钟,分装,每袋10克,得到中药散剂。
上述中药散剂使用时直接取一包放入150mL温水中搅拌均匀,一日三次,每次一包,3天为一个疗程,连续服用3个疗程。
本发明实施例1-3中的制备方法步骤(2)中采用的提取溶剂为质量分数为95%的乙醇。本发明采用的原料均为市售中药药材。
对比例1
一种中药组合物,其技术方案与实施例1基本一致,不同之处在于:将其中的云实、附子和当归替换为金银花、肉桂和单参。
对比例2
一种中药组合物,其技术方案与实施例1基本一致,不同之处在于:将其中的黄芪、党参和六神曲替换为白术、人参和麦芽。
对比例3
一种中药组合物,其技术方案与实施例1基本一致,不同之处在于:将其中的六月雪替换为独活,肉桂替换为干姜,巴戟天替换为鹿茸。
对比例4
一种中药组合物,其技术方案与实施例1基本一致,不同之处在于:制备方法中步骤(1)为:将云实、附子、当归、黄芪、党参、六神曲粉碎后,加入纯净水浸泡24小时,加入云实、附子、当归、黄芪、党参、六神曲总重量3倍的95%的乙醇溶液加热回流3.5小时,获得第一提取液。
对比例5
一种中药组合物,其技术方案与实施例1基本一致,不同之处在于:制备方法中步骤(2)为:将威灵仙、肉桂、六月雪、巴戟天、桂枝粉碎后加入纯净水,加入水的重量为威灵仙、肉桂、六月雪、巴戟天、桂枝总重量的10倍,在100℃下煎煮4小时,重复煎煮两次后过滤,滤液减压浓缩,得到第二提取液。
对比例6
一种中药组合物,其技术方案与实施例1基本一致,不同之处在于:制备方法中步骤(3)为:将第一提取液和第二提取液混合,减压浓缩,放置在80℃的烘箱中烘干,粉碎,过筛,灭菌,得到中药散剂。
毒性试验
选择80只健康的实验用小白鼠,质量200±5g,随机分为四组,每组20只,其中雌鼠和雄鼠各10只。其中1-3组为实验组分别喂实施例1-3制备的中药组合物,一日一次,饭后服用,每只喂50毫克的药加2毫升水溶解,最后一组作为对照,饭后仅喂2毫升水。在同样的环境中喂普通饲料,实验周期为2个月。
实验结束后,检验实验组小白鼠的血液细胞学指标、血液生化学指标与对照组的无明显差异。将4组小白鼠处死后内脏进行病理切片染色检查,实验组小白鼠脏器组织结构排列有序,细胞形态正常,染色清晰,与对照组比较无明显差异。
毒性试验表明,本发明实施例1-3提供的中药组合物对小白鼠长期给药后未见毒性反应。
临床试验
选择年龄在45-60周岁的360名风湿性关节炎患者,分为9组,每组40人。每组患者分别使用实施例1-3和对比例1-6提供的中药组合物,一日三次,连续服用9天,治疗情况如表1所示。
疗效标准如下:
痊愈:症状消失,关节功能恢复;有效:症状减轻,关节活动障碍有所改善;无效:治疗前后无任何变化。
表1风湿性关节炎治疗效果
其中表1中的总有效率为有效率与痊愈率之和。
从表1中可以看出,本发明实施例1-3提供的中药组合物具有显著的治疗效果,痊愈率在67.5%以上,比对比例1-3提供的中药组合物至少高32.5%;实施例1-3总有效率在90%,比对比例1-3提供的中药组合物至少高20%。
通过实施例1与对比例4-6治疗效果可以看出,本发明实施例1的治疗效果最好,该中药组合物的制备方法能够充分的提取各个药物中的有效成分,使药性发挥到最大,保护药物中的有效成分和活性不被破坏,从而保证好的治疗效果。
上述痊愈的患者停药六个月后进行随访,统计风湿性关节炎复发情况,如表2所示。
表2停药后的复发结果
通过表2可以看出,本发明实施例1-3提供的中药组合物,复发率最高仅为22.2%,与对比例1-3相比,复发率至少低了27.8%,本发明提供的中药组合物治愈风湿后不易复发。
最后应说明的是:以上各实施例仅用以说明本发明的技术方案,而非对其限制;尽管参照前述各实施例对本发明进行了详细的说明,本领域的普通技术人员应当理解:其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分或者全部技术特征进行等同替换;而这些修改或者替换,并不使相应技术方案的本质脱离本发明各实施例技术方案的范围。
Claims (10)
1.一种治疗风湿的中药组合物,其特征在于,包括以下重量份的原料:威灵仙10-12份、肉桂10-12份、六月雪10-12份、巴戟天12-15份、桂枝8-10份、云实15-20份、附子8-13份、当归9-14份、黄芪25-28份、党参15-17份、六神曲15-17份。
2.根据权利要求1所述的治疗风湿的中药组合物,其特征在于,包括以下重量份的原料:威灵仙10份、肉桂10份、六月雪10份、巴戟天12份、桂枝8份、云实15份、附子8份、当归10份、黄芪25份、党参15份、六神曲17份。
3.一种权利要求1-2任一所述的治疗风湿的中药组合物的制备方法,其特征在于,将上述所有原料加工制成中药制剂。
4.根据权利要求3所述的制备方法,其特征在于,所述中药制剂为散剂、丸剂、膏剂、口服液或药酒。
5.根据权利要求4所述的制备方法,其特征在于,所述中药制剂为散剂。
6.根据权利要求5所述的制备方法,其特征在于,包括以下步骤:
(1)将云实、附子、当归、黄芪、党参、六神曲粉碎后,加入纯净水浸泡后煎煮,煎煮后获得第一提取液;
(2)将威灵仙、肉桂、六月雪、巴戟天、桂枝粉碎后加入超声逆流提取设备中,加入提取溶剂乙醇,提取后,过滤,滤液减压浓缩,得到第二提取液;
(3)将第一提取液和第二提取液混合,减压浓缩,真空冷冻干燥,粉碎,过筛,灭菌,得到中药散剂。
7.根据权利要求6所述的制备方法,其特征在于,所述步骤(1)中浸泡时间为20-24小时,加水煎煮两次,每次煎煮加入药材重量2-3倍的水,在95-100℃的条件下煎煮3-4小时。
8.根据权利要求6所述的制备方法,其特征在于,所述步骤(2)中加入乙醇的重量为药材重量的8-10倍,超声频率设置为30-50kHz,温度为45-50℃,提取时间为4-5小时。
9.根据权利要求6所述的制备方法,其特征在于,所述步骤(3)中的真空冷冻干燥具体过程为:在0.1Pa-0.3Pa真空度下,先在-25℃--30℃下冷冻7-8h,然后以每分钟1-2℃的速度缓慢升温,至0-5℃下干燥3-4h,再以每分钟1-2℃的速度继续缓慢升温,至25-30℃下干燥14-15h。
10.根据权利要求6所述的制备方法,其特征在于,所述步骤(3)中过筛采用80-100目筛;灭菌采用紫外线辐射处理40-50分钟。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202310285950.2A CN116392530A (zh) | 2023-03-22 | 2023-03-22 | 一种治疗风湿的中药组合物及制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202310285950.2A CN116392530A (zh) | 2023-03-22 | 2023-03-22 | 一种治疗风湿的中药组合物及制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN116392530A true CN116392530A (zh) | 2023-07-07 |
Family
ID=87017024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202310285950.2A Pending CN116392530A (zh) | 2023-03-22 | 2023-03-22 | 一种治疗风湿的中药组合物及制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN116392530A (zh) |
-
2023
- 2023-03-22 CN CN202310285950.2A patent/CN116392530A/zh active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101461911B (zh) | 一种治疗痛风的中药内服胶囊 | |
CN101703692A (zh) | 一种治疗骨伤的中药制剂及其制备方法 | |
CN1051237C (zh) | 治疗癫痫病的药物 | |
CN101011544A (zh) | 痛风速康颗粒(胶囊)及其制作工艺 | |
CN102078527A (zh) | 一种治疗泌尿结石的中药配方 | |
CN101537160B (zh) | 一种排毒养颜保健品 | |
CN101239159B (zh) | 一种治疗类风湿性关节炎的中药组合物及其制备方法 | |
CN103027978A (zh) | 一种治疗跌打损伤的药物组合物及其制备方法 | |
CN1111046C (zh) | 一种治疗妇女产后症的中药制剂 | |
CN116392530A (zh) | 一种治疗风湿的中药组合物及制备方法 | |
CN1127344C (zh) | 一种治疗糖尿病及其并发症的口服丸剂 | |
CN1186067C (zh) | 治疗急性筋伤的药物及其制备方法 | |
CN101485716A (zh) | 一种治疗放射损伤药物及其制备方法 | |
CN1286515C (zh) | 一种治疗囊肿的药物组合物 | |
CN104547489A (zh) | 一种中药组合物在制备治疗粉碎性骨折药物中的用途 | |
CN112755137B (zh) | 一种治疗轻中度膝骨关节炎的中药组合物及其应用 | |
CN102631435A (zh) | 一种治疗类风湿性关节炎的药物 | |
CN107281444B (zh) | 一种止痛的药物组合物及其制备方法和用途 | |
CN108888736B (zh) | 一种外用接骨续筋药及其制备方法 | |
CN1238013C (zh) | 治疗心肌炎的中药制剂 | |
CN1299752C (zh) | 治疗***的中药胶囊及其生产方法 | |
CN1218738C (zh) | 活血止痛内服中成药 | |
CN107233540A (zh) | 一种治疗类风湿关节炎的中药组合物 | |
CN101062233A (zh) | 一种接骨散及其制备方法 | |
CN1322879C (zh) | 一种治疗早中期强直性脊柱炎的药物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |