CN116350560A - 修护牙釉质的生物玻璃牙膏及其制备工艺 - Google Patents
修护牙釉质的生物玻璃牙膏及其制备工艺 Download PDFInfo
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Abstract
本发明公开了修护牙釉质的生物玻璃牙膏及其制备工艺,以重量百分比计包括如下组分:微纳米生物玻璃35‑45%、生物玻璃凝胶30‑40%、纳米羟基磷灰石12‑17%、百香果提取物2‑4%、薄荷油0.1‑1%、珍珠粉1.5‑2.5%、碳酸钙0.1‑0.5%、天然冰片2‑4%、起泡剂0.5‑0.8%,去离子水余量,本发明中的修护牙釉质的生物玻璃牙膏由于添加了将微纳米生物玻璃、生物玻璃凝胶、富勒烯纳米颗粒,能够形成纳米颗粒聚合团状物,提高形成固化层的速度,且提高固化层的质量从而更好的保护牙龈,缓解牙龈萎缩、减缓牙龈出血、缓及防治牙齿松动、防治牙周病、修护牙釉质、减少牙敏感、坚固牙齿和促进牙齿生长的效果,且在形成的过程中和形成后有效的抑制。
Description
技术领域
本发明涉及牙膏领域,具体为修护牙釉质的生物玻璃牙膏及其制备工艺。
背景技术
牙膏是洁牙制品的一种,一般呈凝胶状,通常会抹在牙刷上,借助牙刷的机械摩擦的作用清洁牙齿表面,对牙齿及其周边进行清洁,使口腔净化清爽。而牙齿敏感、痛疼、出血等疾病主要通过修复牙釉质和封堵牙本质小管来阻隔刺激源,那么对牙釉质修复就需要有材料非常非常接近牙釉质成份,而封堵牙本质小管就需要尽可能高的提高封堵率及封堵长度来达到,其中生物活性玻璃、羟基磷灰石有良好的修复与封堵效果,生物玻璃是通过在生物环境中与体液中发生化学反应,在其界面形成多孔的SiO2凝胶层,随后生物玻璃内的Ca2+和体液中的PO43-向SiO2凝胶层扩散、沉积,逐渐发生矿化,进而在其表面形成羟基磷灰石hydroxyapatite,HA覆盖层,实现生物玻璃与宿骨之间的化学键性结合,这种键合非常牢固,与正常愈合的骨折界面强度等效。生物活性玻璃是一种能与牙组织发生物理及化学反应的新型高科技生物活性材料,该材料能迅速与水及唾液发生持续的离子交换、提高氧分压和pH值、产生较强负电荷,瞬间在口腔形成由HA(羟基磷酸灰石)组成的多孔网络支架,网架吸附了大量的硅离子、钠离子、锶离子、钙离子和磷离子,易于附着并渗透牙组织,同时与牙骨组织和软组织有良好的生物相容性。
现有的生物玻璃牙膏形成固化层的速度缓慢,无法很好地减缓牙龈出血和修护牙釉质,并且牙膏的适用度不高。
发明内容
本发明的目的在于提供修护牙釉质的生物玻璃牙膏及其制备工艺,以解决上述背景技术中提出的现有的生物玻璃牙膏形成固化层的速度缓慢,无法很好地减缓牙龈出血和修护牙釉质,并且牙膏的适用度不高的问题。
为实现上述目的,本发明提供如下技术方案:修护牙釉质的生物玻璃牙膏,以重量百分比计包括如下组分:微纳米生物玻璃35-45%、生物玻璃凝胶30-40%、纳米羟基磷灰石12-17%、百香果提取物2-4%、薄荷油0.1-1%、珍珠粉1.5-2.5%、碳酸钙0.1-0.5%、天然冰片2-4%、起泡剂0.5-0.8%,去离子水余量。
优选的,微纳米生物玻璃37%、生物玻璃凝胶38%、纳米羟基磷灰石12%、百香果提取物3%、薄荷油0.5%、碳酸钙0.3%、珍珠粉2%、天然冰片2%、起泡剂0.6%,去离子水4.6%。
优选的,微纳米生物玻璃38%、生物玻璃凝胶38%、纳米羟基磷灰石13%、百香果提取物3%、薄荷油0.4%、碳酸钙0.2%、珍珠粉2%、天然冰片2%、起泡剂0.6%,去离子水2.8%。
优选的,微纳米生物玻璃39%、生物玻璃凝胶38%、纳米羟基磷灰石14%、百香果提取物2%、薄荷油0.4%、碳酸钙0.2%、珍珠粉2%、天然冰片2%、起泡剂0.6%,去离子水2.8%。
优选的,所述生物活性玻璃具体为纳米生物活性玻璃粉末,所述纳米生物活性玻璃粉末的粒径为20-5000nm。
优选的,所述生物玻璃凝胶的粒径为6-20um,所述生物玻璃凝胶与所述纳米生物活性玻璃粉末的粒径比例为7∶1-13∶1。
修护牙釉质的生物玻璃牙膏的制备工艺,包括以下步骤,包括以下步骤:
S1、备料:根据配方所选材料要求,按照对应的配比称量材料;
S2、预溶解:先向预溶解罐中导入少量去离子水,再将S1中配好的碳酸钙、百香果提取物和天然冰片导入到预溶解罐中进行溶解,得到组分A;
S3、一次混合:将S1中配好的微纳米生物玻璃和纳米羟基磷灰石进行混合、搅拌以及超声波均质后得到组分B;
S4、二次混合:将S1中配好的生物玻璃凝胶来与S2中得到的组分A进行混合搅拌得到组分C;
S5、三次混合:将S3中得到的组分B与S4中得到的组分C进行混合、搅拌以及超声波均质后得到组分D;
S6、四次混合:在低温高压的环境下来将S5中得到的组分D来与薄荷油、珍珠粉、起泡剂和剩余去离子水进行混合、搅拌以及超声波均质后得到所述修护牙釉质的生物玻璃牙膏。
优选的,所述S6步骤中,低温高压具体为温度10~20℃、压力350~420MPa。
与现有技术相比,本发明的有益效果是:本发明中的修护牙釉质的生物玻璃牙膏由于添加了将微纳米生物玻璃、生物玻璃凝胶、富勒烯纳米颗粒,能够形成纳米颗粒聚合团状物,提高形成固化层的速度,且提高固化层的质量从而更好的保护牙龈,缓解牙龈萎缩、减缓牙龈出血、缓及防治牙齿松动、防治牙周病、修护牙釉质、减少牙敏感、坚固牙齿和促进牙齿生长的效果,且在形成的过程中和形成后有效的抑制,同时在牙膏中添加了百香果提取物,能够进一步提高牙膏的适用度,避免在刷牙时产生不适,还能起到清新口气的效果。
具体实施方式
下面将结合本发明实施例,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1
本发明提供了修护牙釉质的生物玻璃牙膏,以重量百分比计包括如下组分:微纳米生物玻璃37%、生物玻璃凝胶38%、纳米羟基磷灰石12%、百香果提取物3%、薄荷油0.5%、碳酸钙0.3%、珍珠粉2%、天然冰片2%、起泡剂0.6%,去离子水4.6%。
修护牙釉质的生物玻璃牙膏的制备工艺,包括以下步骤
S1、备料:根据配方所选材料要求,按照对应的配比称量材料;
S2、预溶解:先向预溶解罐中导入少量去离子水,再将S1中配好的碳酸钙、百香果提取物和天然冰片导入到预溶解罐中进行溶解,得到组分A;
S3、一次混合:将S1中配好的微纳米生物玻璃和纳米羟基磷灰石进行混合、搅拌以及超声波均质后得到组分B;
S4、二次混合:将S1中配好的生物玻璃凝胶来与S2中得到的组分A进行混合搅拌得到组分C;
S5、三次混合:将S3中得到的组分B与S4中得到的组分C进行混合、搅拌以及超声波均质后得到组分D;
S6、四次混合:在温度10~20℃、压力350~420MPa的环境下来将S5中得到的组分D来与薄荷油、珍珠粉、起泡剂和剩余去离子水进行混合、搅拌以及超声波均质后得到所述修护牙釉质的生物玻璃牙膏。
该实施例中:修护牙釉质的生物玻璃牙膏由于添加了将微纳米生物玻璃、生物玻璃凝胶、富勒烯纳米颗粒,能够形成纳米颗粒聚合团状物,提高形成固化层的速度,且提高固化层的质量从而更好的保护牙龈,缓解牙龈萎缩、减缓牙龈出血、缓及防治牙齿松动、防治牙周病、修护牙釉质、减少牙敏感、坚固牙齿和促进牙齿生长的效果,且在形成的过程中和形成后有效的抑制口腔内细菌的滋生,保存口腔健康,从而防止牙龈受损,起到保护牙龈的作用。
实施例2
本发明提供了修护牙釉质的生物玻璃牙膏,以重量百分比计包括如下组分:微纳米生物玻璃38%、生物玻璃凝胶38%、纳米羟基磷灰石13%、百香果提取物3%、薄荷油0.4%、碳酸钙0.2%、珍珠粉2%、天然冰片2%、起泡剂0.6%,去离子水2.8%。
修护牙釉质的生物玻璃牙膏的制备工艺,包括以下步骤
S1、备料:根据配方所选材料要求,按照对应的配比称量材料;
S2、预溶解:先向预溶解罐中导入少量去离子水,再将S1中配好的碳酸钙、百香果提取物和天然冰片导入到预溶解罐中进行溶解,得到组分A;
S3、一次混合:将S1中配好的微纳米生物玻璃和纳米羟基磷灰石进行混合、搅拌以及超声波均质后得到组分B;
S4、二次混合:将S1中配好的生物玻璃凝胶来与S2中得到的组分A进行混合搅拌得到组分C;
S5、三次混合:将S3中得到的组分B与S4中得到的组分C进行混合、搅拌以及超声波均质后得到组分D;
S6、四次混合:在温度10~20℃、压力350~420MPa的环境下来将S5中得到的组分D来与薄荷油、珍珠粉、起泡剂和剩余去离子水进行混合、搅拌以及超声波均质后得到所述修护牙釉质的生物玻璃牙膏。
该实施例中:该实施例与实施例一相比,在所制得的修护牙釉质的生物玻璃牙膏中将微纳米生物玻璃的重量百分比提升至38%、纳米羟基磷灰石的重量百分比提升至13%,能够更好对牙龈起到防护作用,来进一步减缓牙龈出血以及抑制口腔细菌的滋生。
实施例3
本发明提供了修护牙釉质的生物玻璃牙膏,以重量百分比计包括如下组分:微纳米生物玻璃39%、生物玻璃凝胶38%、纳米羟基磷灰石14%、百香果提取物2%、薄荷油0.4%、碳酸钙0.2%、珍珠粉2%、天然冰片2%、起泡剂0.6%,去离子水2.8%。
修护牙釉质的生物玻璃牙膏的制备工艺,包括以下步骤
S1、备料:根据配方所选材料要求,按照对应的配比称量材料;
S2、预溶解:先向预溶解罐中导入少量去离子水,再将S1中配好的碳酸钙、百香果提取物和天然冰片导入到预溶解罐中进行溶解,得到组分A;
S3、一次混合:将S1中配好的微纳米生物玻璃和纳米羟基磷灰石进行混合、搅拌以及超声波均质后得到组分B;
S4、二次混合:将S1中配好的生物玻璃凝胶来与S2中得到的组分A进行混合搅拌得到组分C;
S5、三次混合:将S3中得到的组分B与S4中得到的组分C进行混合、搅拌以及超声波均质后得到组分D;
S6、四次混合:在温度10~20℃、压力350~420MPa的环境下来将S5中得到的组分D来与薄荷油、珍珠粉、起泡剂和剩余去离子水进行混合、搅拌以及超声波均质后得到所述修护牙釉质的生物玻璃牙膏。
该实施例中:该实施例与实施例一相比,在所制得的修护牙釉质的生物玻璃牙膏中将微纳米生物玻璃的重量百分比提升至39%、纳米羟基磷灰石的重量百分比提升至14%,能够更快的形成更好的固化层,能够更好的保护牙龈,进而有效缓解牙龈出血,提高对牙釉质的修护效果。
尽管参照前述实施例对本发明进行了详细的说明,对于本领域的技术人员来说,其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换,凡在本发明的精神和原则之内,所做的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (8)
1.修护牙釉质的生物玻璃牙膏,其特征在于,以重量百分比计包括如下组分:微纳米生物玻璃35-45%、生物玻璃凝胶30-40%、纳米羟基磷灰石12-17%、百香果提取物2-4%、薄荷油0.1-1%、珍珠粉1.5-2.5%、碳酸钙0.1-0.5%、天然冰片2-4%、起泡剂0.5-0.8%,去离子水余量。
2.根据权利要求1所述的修护牙釉质的生物玻璃牙膏,其特征在于,以重量百分比计包括如下组分:微纳米生物玻璃37%、生物玻璃凝胶38%、纳米羟基磷灰石12%、百香果提取物3%、薄荷油0.5%、碳酸钙0.3%、珍珠粉2%、天然冰片2%、起泡剂0.6%,去离子水4.6%。
3.根据权利要求1所述的修护牙釉质的生物玻璃牙膏,其特征在于,以重量百分比计包括如下组分:微纳米生物玻璃38%、生物玻璃凝胶38%、纳米羟基磷灰石13%、百香果提取物3%、薄荷油0.4%、碳酸钙0.2%、珍珠粉2%、天然冰片2%、起泡剂0.6%,去离子水2.8%。
4.根据权利要求1所述的修护牙釉质的生物玻璃牙膏,其特征在于,以重量百分比计包括如下组分:微纳米生物玻璃39%、生物玻璃凝胶38%、纳米羟基磷灰石14%、百香果提取物2%、薄荷油0.4%、碳酸钙0.2%、珍珠粉2%、天然冰片2%、起泡剂0.6%,去离子水2.8%。
5.根据权利要求1所述的修护牙釉质的生物玻璃牙膏,其特征在于:所述生物活性玻璃具体为纳米生物活性玻璃粉末,所述纳米生物活性玻璃粉末的粒径为20-5000nm。
6.根据权利要求1所述的修护牙釉质的生物玻璃牙膏,其特征在于:所述生物玻璃凝胶的粒径为6-20um,所述生物玻璃凝胶与所述纳米生物活性玻璃粉末的粒径比例为7∶1-13∶1。
7.如权利要求1-4任一所述的长效去油的修护牙釉质的生物玻璃牙膏的制备工艺,其特征在于,包括以下步骤:
S1、备料:根据配方所选材料要求,按照对应的配比称量材料;
S2、预溶解:先向预溶解罐中导入少量去离子水,再将S1中配好的碳酸钙、百香果提取物和天然冰片导入到预溶解罐中进行溶解,得到组分A;
S3、一次混合:将S1中配好的微纳米生物玻璃和纳米羟基磷灰石进行混合、搅拌以及超声波均质后得到组分B;
S4、二次混合:将S1中配好的生物玻璃凝胶来与S2中得到的组分A进行混合搅拌得到组分C;
S5、三次混合:将S3中得到的组分B与S4中得到的组分C进行混合、搅拌以及超声波均质后得到组分D;
S6、四次混合:在低温高压的环境下来将S5中得到的组分D来与薄荷油、珍珠粉、起泡剂和剩余去离子水进行混合、搅拌以及超声波均质后得到所述修护牙釉质的生物玻璃牙膏。
8.根据权利要求7所述的长效去油的复方酮康唑发用洗剂的制备工艺,其特征在于:所述S6步骤中,低温高压具体为温度10~20℃、压力350~420MPa。
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