CN116270440A - Auxiliary medicine feeding bag wrapping gel for cats - Google Patents

Auxiliary medicine feeding bag wrapping gel for cats Download PDF

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CN116270440A
CN116270440A CN202310443662.5A CN202310443662A CN116270440A CN 116270440 A CN116270440 A CN 116270440A CN 202310443662 A CN202310443662 A CN 202310443662A CN 116270440 A CN116270440 A CN 116270440A
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gel
parts
cat
phagostimulant
adhesive
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Inventor
吴胜良
吴明校
吴柏青
孙振华
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Chongqing Hanpei Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87—Re-use of by-products of food processing for fodder production

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses auxiliary medicine feeding bag wrapping gel for cats, which is characterized in that: is prepared from fresh meat, adhesive, phagostimulant, antiseptic and nutrients; the fresh meat is crushed, added with adhesive, phagostimulant, preservative and nutrient, mixed evenly, put into a mould, frozen below-50 ℃, then frozen, dried, packaged and sterilized to obtain the product. According to the characteristic design of the cat esophagus, the invention is delicious and nutritious for the cat, has good stretchability and plasticity, can prevent the irritation medicine from damaging the cat esophagus, is provided with the taste which the cat likes, covers the medicine smell, can wrap medicines of different dosage forms according to the needs, simplifies medicine feeding procedures and prevents stress. The preparation process of the medicine-coated gel is simple and easy to implement, is convenient to use, and has good commercial prospect.

Description

Auxiliary medicine feeding bag wrapping gel for cats
Technical Field
The invention relates to the technical field of pet medicine, in particular to auxiliary medicine-feeding bag-wrapping gel for cats.
Background
With the continuous enrichment and improvement of material life, the number of raised pets is increased. The number of cats kept is rapidly increasing at present, and the number of dogs in many areas is already exceeding the number of dogs. However, in the feeding process of cats, since cats (particularly, cat breeds) are very critical and firm in taste (since the pet drugs are mainly treated, the taste of the drugs is not very good, the taste is relatively sensitive to both smell and taste, and particularly, for pets suffering from anorexia, the eating desire is difficult to cause), and there is a fear that the cats are easily stressed, so that the feeding of the drugs is very difficult.
And the cat esophagus structure is very different from that of dogs, and 1/3 of the cat esophagus structure is composed of smooth muscle, so that the residence time of the medicine in the esophagus is prolonged, and the cat esophagitis and the perforation of the esophagus are caused by easily stimulating the esophagus, thereby secondary other diseases are caused.
At present, a common pet medicine feeding mode in the market is a pet medicine feeder similar to an injector, a solid tablet is placed at the head of the medicine feeder, and then the medicine feeder is inserted into a pet mouth. And appetite for diseased cats may decrease and the alien drug odor may further increase resistance and stress in cats.
There are also some gel hollow candies designed for feeding medicines to pets in the market at present, such as the gel hollow candies for assisting in feeding medicines to pets disclosed in CN 114514956A, and a preparation method and application thereof. Mainly designed for dogs, but cats have different tastes and esophageal constructions for foods than dogs, so that the effect on cats is not ideal and some esophageal damage is generated, which has been a problem for pets and doctors. Therefore, there is a need to develop a feed wrap gel that is suitable for the eating habits of cats to encapsulate the drug and aid in inducing drug feeding.
Disclosure of Invention
In order to solve the technical problems, the invention provides the auxiliary medicine feeding bag wrapping gel for cats, which is delicious and nutritious for cats, has good stretchability and plasticity, covers medicine odor and can wrap medicines in different dosage forms according to requirements.
In order to achieve the above purpose, the invention is realized by the following technical scheme: an auxiliary medicine feeding bag wrapping gel for cats, which is characterized in that: is prepared from fresh meat, adhesive, phagostimulant, antiseptic and nutrients; the fresh meat is crushed, added with adhesive, phagostimulant, preservative and nutrient, mixed evenly, put into a mould, frozen below-50 ℃, then frozen, dried, packaged and sterilized to obtain the product.
In the scheme, the method comprises the following steps: the fresh meat is one or more of fresh chicken, beef, duck, quail and chicken liver. Fresh meat provides nutritional ingredients for the cat, the cat is induced to eat, and after the fresh meat is freeze-dried, the flavor and nutrition of the fresh meat can be best maintained, and the cat prefers to eat.
In the scheme, the method comprises the following steps: the adhesive is one or more of wheat protein powder, corn extract, cellulose, glycerol and gelatin. The adhesive has the effect of shaping the coated gel and preventing loosening.
In the scheme, the method comprises the following steps: the phagostimulant is one or more of chicken liver powder, beer yeast, chicken oil, beef tallow, catnip and kiwi fruit alkali. The phagostimulant has the effect of inducing the feeding of the cat while providing the favorite taste of the cat.
In the scheme, the method comprises the following steps: the preservative is one or more of tert-butyl hydroquinone, sorbic acid, benzoic acid and sodium diacetate.
In the scheme, the method comprises the following steps: the nutrient is one or more of taurine, compound vitamins, glucose, fish oil and coconut oil.
In the scheme, the method comprises the following steps: the preparation method of the composite material also comprises a wrapping carrier, wherein the wrapping carrier is prepared according to the following method: completely dissolving chitosan in 0.1M/L anti-bad thrombus solution to obtain 5% (w/w) chitosan solution, adding tannic acid or genipin or citric acid or tannin, stirring at 60-70deg.C, and crosslinking until deep color gel is formed; adding crushed fresh meat, adhesive, phagostimulant, preservative and nutrients into the wrapping carrier, uniformly mixing, placing into a mould, freezing at-50deg.C, freeze-drying, packaging and sterilizing to obtain the final product. The inclusion of the encapsulation vehicle forms an image-wise cross-linked structure, so that the encapsulation gel does not loosen in the cat's esophagus, but easily breaks up in gastric acid. Thereby avoiding the stimulation of the medicine to the cat esophagus and avoiding the occurrence of the perforation of esophagitis esophagus.
In the scheme, the method comprises the following steps: according to the weight portions, the meat food is prepared from 100 portions of fresh meat, 20-45 portions of adhesive, 6-20 portions of phagostimulant, 0.5-1 portion of preservative, 1-6 portions of nutrient and 40-60 portions of package carrier.
In the scheme, the method comprises the following steps: the sterilization adopts irradiation sterilization.
The auxiliary medicine feeding bag wrapping gel for the cat is specially designed for the cat, is designed according to the characteristics of the esophagus of the cat, is delicious and nutritious for the cat, has good stretchability and plasticity, can prevent the irritation medicine from damaging the esophagus of the cat, is provided with the favorite taste of the cat, covers the medicine smell, can wrap medicines of different dosage forms as required, simplifies medicine feeding procedures and prevents stress. The preparation process of the medicine-coated gel is simple and easy to implement, is convenient to use, and has good commercial prospect.
Drawings
FIG. 1 is a schematic diagram and reaction of gel carrier cross-linking synthesis.
FIG. 2 is a diagram of a real object prepared by the invention.
FIG. 3 is a graph showing the effect of slow release decomposition under simulated gastric acid conditions. Common commercial gel material (20 min in physiological saline solution), non-coated carrier material (20 min in physiological saline solution), coated carrier material (20 min in physiological saline solution) and coated carrier material (20 min in physiological saline solution).
Fig. 4 is a physical diagram after the medicine is wrapped.
Detailed Description
The invention is further described below with reference to the drawings and examples.
Example 1
Freeze-dried chicken wrapping gel
Firstly, chitosan is completely dissolved in 0.1M/L anti-bad thrombus solution to obtain 5% (w/w) chitosan solution at room temperature, tannic acid with the mass of 0.05% of that of chitosan is added for crosslinking, and stirring is continuously carried out for 20 min at the temperature of 60-70 ℃ until deep color gel is observed to form, then, the following raw materials are added into 60 parts of gel in parts by weight, 100 parts of fresh chicken, 20 parts of wheat protein powder, 2 parts of corn extract, 5 parts of glycerol, 20 parts of chicken liver powder, 2 parts of chicken oil, 5 parts of catnip, 2 parts of beer yeast, 1 part of compound vitamin and 1 part of preservative sorbic acid are uniformly mixed, and then the mixture is put into a mould for freezing at-50 ℃ for 24 hours, and finally, the mixture is frozen and dried for at least 24 hours. And finally spraying 4 parts of coconut oil on the surface of the frozen gel material, and sub-packaging and irradiation sterilization are carried out.
Example 2
100 parts of fresh chicken, 20 parts of wheat protein powder, 2 parts of corn extract, 5 parts of glycerol, 20 parts of chicken liver powder, 2 parts of chicken oil, 5 parts of catnip, 2 parts of beer yeast, 1 part of compound vitamin and 1 part of preservative sorbic acid are uniformly mixed, and then the mixture is put into a mould for freezing for 24 hours at the temperature of minus 50 ℃, and finally the mixture is frozen and dried for at least 24 hours. And finally spraying 4 parts of coconut oil on the surface of the frozen gel material, and sub-packaging and irradiation sterilization are carried out.
Example 3
Beef freeze-drying coating gel
Firstly, chitosan is completely dissolved in 0.1M/L anti-bad thrombus solution to obtain 5% (w/w) chitosan solution at room temperature, tannin with the mass of 0.05% of that of the chitosan is added for crosslinking, and continuously stirred for 20 min at the temperature of 60-70 ℃ until deep color gel is observed to form, then, the following raw materials are added into 40 parts of gel in parts by weight, 100 parts of fresh beef, 20 parts of wheat protein powder, 4 parts of beef tallow, 5 parts of catnip, 5 parts of beer yeast and 1 part of compound vitamin, after being uniformly mixed, 1 part of preservative sodium diacetate is put into a mold for freezing for 24 hours at the temperature of minus 50 ℃, and finally, the freeze drying is carried out for at least 24 hours. And then spraying 2 parts of coconut oil on the surface of the frozen gel material, and sterilizing by irradiation.
Example 4
100 parts of fresh beef, 20 parts of wheat protein powder, 4 parts of beef tallow, 5 parts of catmint, 5 parts of beer yeast and 1 part of compound vitamin, and 1 part of preservative sodium diacetate are uniformly mixed, then the mixture is put into a mould for freezing for 24 hours at the temperature of minus 50 ℃, and finally the mixture is frozen and dried for at least 24 hours. And then spraying 2 parts of coconut oil on the surface of the frozen gel material, and sterilizing by irradiation.
Example 5
Freeze-dried chicken liver coating gel
Firstly, chitosan is completely dissolved in 0.1M/L anti-bad thrombus solution to obtain 5% (w/w) chitosan solution at room temperature, tannic acid with the mass of 0.05% of that of chitosan is added for crosslinking, and stirring is continuously carried out for 20 min at the temperature of 60-70 ℃ until deep color gel is observed to form, and then, the following raw materials, namely, 100 parts of fresh chicken liver, 30 parts of wheat protein powder, 5 parts of cellulose, 5 parts of gelatin, 4 parts of beef tallow, 5 parts of catnip, 3 parts of kiwi fruit alkali, 5 parts of beer yeast and 4 parts of nutrients including 1 part of taurine, 1 part of compound vitamin and 1 part of glucose are added into 50 parts of gel in parts by weight. And (3) uniformly mixing 0.5 part of the preservative tert-butylhydroquinone, putting into a mould, freezing at the temperature of 50 ℃ below zero for 24 hours, and finally, freeze-drying for at least 24 hours. And then spraying 3 parts of coconut oil on the surface of the frozen gel material, and sterilizing by irradiation.
Example 6
100 parts of fresh chicken liver, 30 parts of wheat protein powder, 5 parts of cellulose, 5 parts of gelatin, 4 parts of beef tallow, 5 parts of catmint, 3 parts of kiwi fruit alkali, 5 parts of beer yeast and 4 parts of nutrients, including 1 part of taurine, 1 part of compound vitamin and 1 part of glucose. And (3) uniformly mixing 0.5 part of the preservative tert-butylhydroquinone, putting into a mould, freezing at the temperature of 50 ℃ below zero for 24 hours, and finally, freeze-drying for at least 24 hours. And then spraying 3 parts of coconut oil on the surface of the frozen gel material, and sterilizing by irradiation.
Comparative example 1
Chicken drying and wrapping gel
Firstly, chitosan is completely dissolved in 0.1M/L anti-bad thrombus solution to obtain 5% (w/w) chitosan solution at room temperature, tannic acid with the mass of 0.05% of that of chitosan is added for crosslinking, and stirring is continuously carried out for 20 min at the temperature of 60-70 ℃ until deep color gel is observed to form, then, the following raw materials, 100 parts of fresh chicken, 20 parts of wheat protein powder, 2 parts of corn extract, 5 parts of glycerol, 20 parts of chicken liver powder, 2 parts of chicken oil, 5 parts of catnip, 2 parts of beer yeast, 1 part of compound vitamin and 1 part of preservative sorbic acid are added into 50 parts of gel in parts by weight, and the mixture is uniformly mixed, and then the mixture is put into a die for electric heating and drying. And finally, spraying 4 parts of coconut oil on the surface of the dried gel material, and sub-packaging and irradiation sterilization are carried out.
Test 1
The frozen coated gels provided in examples 1-6 and comparative examples for use in aiding in feeding a pet medicament were taken as test samples.
The pet medicine is amoxicillin and clavulanate potassium hydrochloride anti-inflammatory tablets with large market dosage, and the specification is 50 mg/granule, and the tablet is universal for cats and dogs.
The gel without carrier encapsulation is shown on the left side of figure 1 and the gel with carrier encapsulation is shown on the right side.
7 pet cats in each group are fed with the same feeding environment, the cat food with the same daily amount is fed for free feeding, then the test cats are fed with medicine, the medicine which is not coated with gel and the medicine which is coated with gel are taken out and fed directly at the same time, the cats are not fed forcibly, and the feeding is continued for 4 days; the feeding results were recorded for all 4 days, and specific data are shown in table 1.
Table 1: cat drug-coated gel feeding test result statistical table
Figure BDA0004194849200000061
Figure BDA0004194849200000071
In the figure, "-" indicates a failure of one pet feeding medication and "" indicates a success of one pet feeding medication
As can be seen from the table, with the dried gel, the cat had two non-feeding food on the first day. Cats and dogs are relatively more sensitive to both smell and taste, especially for pets with decreased appetite due to illness, and are difficult to induce a desire to eat. Therefore, by adopting a freeze-drying method, the feeding desire of the cat is more easily caused.
Test 2
Samples of examples 1-6 were taken, and gel wrap materials currently commercially available, to simulate gastric acid digestion in cats for testing
The test method comprises the following steps: the common medicine-coated gel and the gel special for cats developed in the research are compared, the test is carried out in normal saline (20 min) and hydrochloric acid (1 h) with pH=2 respectively, the solution is slightly shaken continuously by simulating the peristaltic motion of esophagus and stomach, and the change of the material is observed. Since the cat eat is directly swallowed, and the cat needs to chew by a person, saliva is not used, and physiological saline can be directly adopted to simulate the esophagus environment of the cat.
Test results: FIG. 3 is a macroscopic view of a drug-coated gel for cats according to an embodiment of the invention after being dissociated under simulated esophageal and gastric acid conditions. A common commercial gel material (20 min in physiological saline solution), B an uncoated carrier material of the invention (20 min in physiological saline solution), c an coated carrier material of the invention (20 min in physiological saline solution) d an coated carrier material of the invention (ph=2 solution).
Experimental results show that the common commercial drug coating material is easy to disperse under the condition of shaking of conventional liquid, the gel of the non-coated gel carrier disclosed by the invention is loose in normal physiological saline, and the gel of the coated carrier disclosed by the invention is stable in physiological saline. And the characteristic of swelling and scattering rapidly under the condition of simulating the pH of gastric acid is very important for protecting the medicine from leaking into the esophagus and decomposing in the stomach.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (9)

1. An auxiliary medicine feeding bag wrapping gel for cats, which is characterized in that: is prepared from fresh meat, adhesive, phagostimulant, antiseptic and nutrients; the fresh meat is crushed, added with adhesive, phagostimulant, preservative and nutrient, mixed evenly, put into a mould, frozen below-50 ℃, then frozen, dried, packaged and sterilized to obtain the product.
2. The auxiliary cat feed casing gel of claim 1, wherein: the fresh meat is one or more of fresh chicken, beef, duck, quail and chicken liver.
3. The auxiliary cat feed casing gel of claim 2, wherein: the adhesive is one or more of wheat protein powder, corn extract, cellulose, glycerol and gelatin.
4. A cat auxiliary feed wrap gel according to claim 3, wherein: the phagostimulant is one or more of chicken liver powder, beer yeast, chicken oil, beef tallow, catnip and kiwi fruit alkali.
5. The auxiliary cat feed casing gel of claim 4, wherein: the preservative is one or more of tert-butyl hydroquinone, sorbic acid, benzoic acid and sodium diacetate.
6. The auxiliary cat feed casing gel of claim 5, wherein: the nutrient is one or more of taurine, compound vitamins, glucose, fish oil and coconut oil.
7. The auxiliary cat feed casing gel of claim 1, wherein: the preparation method of the composite material also comprises a wrapping carrier, wherein the wrapping carrier is prepared according to the following method: completely dissolving chitosan in 0.1M/L anti-bad thrombus solution to obtain 5% (w/w) chitosan solution, adding tannic acid or genipin or citric acid or tannin, stirring at 60-70deg.C, and crosslinking until deep color gel is formed; adding crushed fresh meat, adhesive, phagostimulant, preservative and nutrients into the wrapping carrier, uniformly mixing, placing into a mould, freezing at-50deg.C, freeze-drying, packaging and sterilizing to obtain the final product.
8. The auxiliary cat feed casing gel of claim 7, wherein: according to the weight portions, the meat food is prepared from 100 portions of fresh meat, 20 to 45 portions of adhesive, 6 to 20 portions of phagostimulant, 0.5 to 1 portion of preservative, 1 to 6 portions of nutrient and 40 to 60 portions of package carrier.
9. The auxiliary cat feed casing gel of claim 8, wherein: the sterilization adopts irradiation sterilization.
CN202310443662.5A 2023-04-24 2023-04-24 Auxiliary medicine feeding bag wrapping gel for cats Pending CN116270440A (en)

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