CN116270311A - Sun-proof moisturizing repair film composition with liquid crystal structure - Google Patents
Sun-proof moisturizing repair film composition with liquid crystal structure Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/87—Polyurethanes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0295—Liquid crystals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/496—Triazoles or their condensed derivatives, e.g. benzotriazoles
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4966—Triazines or their condensed derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
The invention discloses a sun-proof moisturizing repair film composition with a liquid crystal structure, which comprises the following components in percentage by mass: 40-60% of bionic liquid crystal structure repairing film, the balance being macromolecular polyurethane film, the sum of the mass percentages of the components being 100%. The bionic liquid crystal structure repairing film comprises: 2-8% of emulsifying agent, 0.2-2% of repairing agent, 5-15% of bionic humectant, 8-25% of grease and the balance of water; the macromolecular polyurethane film comprises: 5-25% of polyurethane, 7-25% of macromolecular sun-screening agent, 10-20% of stabilizing agent and the balance of water. The composition has a special liquid crystal structure, is skin-friendly and skin-adhering, is safe and harmless to human bodies, and can be used for all skin types.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a sun-proof moisturizing repair film composition with a liquid crystal structure.
Background
The liquid crystal skin care product is a novel skin care product which is paid attention to in recent years and can play roles of efficiently moisturizing, releasing active ingredients and the like, but the liquid crystal skin care product is widely used at present and has a certain limitation. Firstly, the types of emulsifying agents for preparing the liquid crystal skin care product are few, and most of the emulsifying agents focus on the research of alkyl glycoside emulsifying agents and sucrose ester emulsifying agents, so that the types of emulsifying agents for preparing the liquid crystal skin care product are required to be further widened; the liquid crystal structure of the liquid crystal skin care product tends to be reduced in the storage process, and the oil and the emulsifier molecules forming the liquid crystal structure are mutually dissolved with other oil molecules in the storage process, so that the ordered arrangement of oil and water interface oil and the emulsifier is gradually reduced, and the liquid crystal structure is reduced. Therefore, the improvement of the stability of the product, the enhancement of the moisturizing effect and the promotion of the penetration of the active ingredients are the problems to be solved in the process of realizing the efficacy of the cosmetics, and the unique advantages of the liquid crystal structure system, such as the highly ordered structure, the unique optical effect, the better affinity of the skin and the like, enable the efficacy of the cosmetics to be reflected, thus providing a wider space for the development of the cosmetics.
Sun protection refers to the blocking or absorbing of ultraviolet light by some means for the purpose of preventing skin from tanning, sunburn, etc. The general sun protection method comprises the following steps: the sun-proof product is smeared, and articles such as sun-proof clothes, umbrellas and the like are used. Sun protection products are classified as physical sun protection, chemical sun protection, biological sun protection; physical sunscreens are equivalent to putting a layer of uv protective clothing on the skin. However, the physical sun protection texture is generally heavy and sticky, is not easy to push away when being used on the skin, and is easy to cause facial blushing. Most of the chemical sunscreens are chemical sunscreens, and resist sunburn by absorbing ultraviolet rays, but have poor light stability, are easy to be absorbed by skin penetration, are directly smeared to have certain injury to skin, and cannot be used by sensitive muscles and postoperative skin. The biological sun-screening agent has no ultraviolet absorption capability and can only play a role in indirect sun screening.
Disclosure of Invention
The invention aims to provide a sun-proof moisturizing repair film composition with a liquid crystal structure, which not only can repair and protect skin, but also can effectively resist damage of ultraviolet rays and UV light.
The invention adopts the technical scheme that the sun-proof moisturizing repair film composition with the liquid crystal structure comprises the following components in percentage by mass: 40-60% of bionic liquid crystal structure repairing film, the balance being macromolecular polyurethane film, the sum of the mass percentages of the components being 100%.
The present invention is also characterized in that,
the bionic liquid crystal structure repairing film comprises the following components in percentage by mass: 2-8% of emulsifying agent, 0.2-2% of repairing agent, 5-15% of bionic humectant, 8-25% of grease and the balance of water, wherein the sum of the mass percentages of the components is 100%.
The preparation process of the bionic liquid crystal structure repair film comprises the following steps: heating water and bionic humectant in the bionic liquid crystal structure repairing film to 80-90 ℃, heating emulsifier and grease to 80-90 ℃, mixing and homogenizing the water and the oil at the rotation speed of 5000-8000r/min for 2-4 times, cooling to room temperature, and adding repairing agent to form the repairing film.
The emulsifier is one or more of behenyl alcohol, cetyl alcohol, stearyl alcohol, cetostearyl glucoside, sodium stearyl glutamate, methyl glucose sesquistearate, PEG-20 methyl glucose sesquistearate, and lecithin.
The repairing agent comprises the following components in percentage by mass: 20-30% of oligopeptide, 20-30% of small molecular heat shock protein and the balance of macromolecular recombinant collagen, wherein the sum of the mass percentages of the components is 100%;
the bionic humectant comprises the following components in percentage by mass: 1-3% of carbomer, 1-3% of ceramide, 1-3% of sodium hyaluronate with the molecular weight of 120-180w, 5-15% of pyrrolidone carboxylic acid sodium, 10-20% of 1, 2-pentanediol, 20-40% of amino acid and 16-62% of glycerol as the rest, wherein the sum of the mass percentages of the components is 100%.
The macromolecular polyurethane film comprises the following components in percentage by mass: 5-25% of polyurethane, 7-25% of macromolecular sun-screening agent, 10-20% of stabilizing agent and the balance of water, wherein the sum of the mass percentages of the components is 100%.
The preparation process of the macromolecular polyurethane film comprises the following steps: heating one part of water, macromolecular sun-screening agent and stabilizing agent in the macromolecular polyurethane film to 80-90 ℃, mixing and homogenizing, cooling to room temperature, and adding polyurethane dissolved in the other part of water to obtain the polyurethane film.
The polyurethane is one or more of polyurethane with polymerization degree of 1,2, 11, 14, 15 and 35; the macromolecular sun-screening agent consists of bis-ethylhexyloxyphenol methoxyphenyl triazine, methylene bis-benzotriazole tetramethylbutylphenol and ethoxyethyl triazone.
The stabilizer comprises the following components in percentage by mass: 15-25% of cetostearyl alcohol, 10-15% of butanediol, 10-15% of glycerol, 5-10% of 1, 2-pentanediol, 1-2% of octanediol, and the balance of isopropyl palmitate, wherein the sum of the mass percentages of the components is 100%.
The beneficial effects of the invention are as follows:
1. the oligopeptide, the small molecular heat shock protein and the large molecular recombinant collagen used in the invention are repaired by different molecular weights, the small molecular heat shock protein is stress protein which is homologous to a human body, and generates stress reaction when the external temperature is high, so that the collagen of the small molecular heat shock protein is protected from being damaged by ultraviolet rays, the repair capability is strong, the small molecular heat shock protein and the bionic humectant can repair the skin which is damaged by the ultraviolet rays at the same time with the oligopeptide, the large molecular collagen and the bionic humectant can play a good role in moisturizing, and the damage of the ultraviolet rays to the skin is reduced; the outer carrier is of a liquid crystal structure, which is equivalent to the second layer of skin, and is used for transmitting active substances while resisting the external environment;
2. the composition has a special liquid crystal structure, is skin-friendly and skin-adhering, is safe and harmless to human bodies, and can be used for all skin types;
3. the sun-screening agent used in the invention is macromolecular chemical sun-screening agent which is difficult to penetrate through skin barrier, so that irritation to skin is avoided, the texture is fresh and cool, and the double advantages of physical and chemical sun-screening are combined; in addition, the sun-proof and after-sun repair cream is convenient to use, has good sun-proof and after-sun repair effects, and can effectively prevent skin from being sunburned and sunburned.
Drawings
FIG. 1 is a schematic view of the liquid crystal structure (I) of the composition prepared in example 1 after being left at a low temperature of 1 m;
FIG. 2 is a schematic diagram of the liquid crystal structure (II) after 1m of the composition prepared in example 1 was left at low temperature;
FIG. 3 is a schematic diagram of the liquid crystal structure (I) of the composition prepared in comparative example 1 after being left at a low temperature of 1 m;
FIG. 4 is a schematic diagram of the liquid crystal structure (II) after leaving the composition prepared in comparative example 1 at a low temperature for 1 m;
FIG. 5 is a schematic diagram of the liquid crystal structure (one) of the composition prepared in comparative example 2 after being left at a low temperature of 1 m;
FIG. 6 is a schematic diagram of the liquid crystal structure (II) after 1m of the composition prepared in comparative example 2 was left at a low temperature.
Detailed Description
The invention will be described in detail below with reference to the drawings and the detailed description.
The invention relates to a sun-proof moisturizing repair film composition with a liquid crystal structure, which comprises the following components in percentage by mass: 40-60% of bionic liquid crystal structure repairing film, the balance being macromolecular polyurethane film, wherein the sum of the mass percentages of the components is 100%;
the bionic liquid crystal structure repairing film comprises the following components in percentage by mass: 2-8% of emulsifying agent, 0.2-2% of repairing agent, 5-15% of bionic humectant, 8-25% of grease and the balance of water, wherein the sum of the mass percentages of the components is 100%;
the emulsifier is one or more of behenyl alcohol, cetyl alcohol, stearyl alcohol, cetostearyl glucoside, sodium stearyl glutamate, methyl glucose sesquistearate, PEG-20 methyl glucose sesquistearate and lecithin;
the repairing agent comprises the following components in percentage by mass: 20-30% of oligopeptide, 20-30% of small molecule heat shock proteins (sHSPs), and the balance of macromolecular recombinant collagen, wherein the sum of the mass percentages of the components is 100%;
the bionic humectant comprises the following components in percentage by mass: 1-3% of carbomer, 1-3% of ceramide, 1-3% of sodium hyaluronate with the molecular weight of 120-180w, 5-15% of sodium pyrrolidone carboxylate, 10-20% of 1, 2-pentanediol, 20-40% of amino acid and 16-62% of glycerol as the rest, wherein the sum of the mass percentages of the components is 100%;
the oil is one or more of natural vegetable oil and natural oil.
The macromolecular polyurethane film comprises the following components in percentage by mass: 5-25% of polyurethane, 7-25% of macromolecular sun-screening agent, 10-20% of stabilizer and the balance of water, wherein the sum of the mass percentages of the components is 100%;
the polyurethane is one or more of polyurethane with polymerization degree of 1,2, 11, 14, 15 and 35;
the macromolecular sun-screening agent consists of bis-ethylhexyloxyphenol methoxyphenyl triazine, methylene bis-benzotriazole tetramethylbutylphenol and ethoxyethyl triazone.
The stabilizer comprises the following components in percentage by mass: 15-25% of cetostearyl alcohol, 10-15% of butanediol, 10-15% of glycerol, 5-10% of 1, 2-pentanediol, 1-2% of octanediol and the balance of isopropyl palmitate, wherein the sum of the mass percentages of the components is 100%;
the invention relates to a preparation method of a sun-proof moisturizing repair film composition with a liquid crystal structure, which specifically comprises the following steps:
step 1, heating water and a bionic humectant in a bionic liquid crystal structure repairing film to 80-90 ℃, heating an emulsifying agent and grease to 80-90 ℃, mixing and homogenizing the water and the oil at the rotation speed of 5000-8000r/min for 2-4 times, cooling to room temperature, and adding a repairing agent to form the repairing film;
and 2, heating one part of water, a macromolecular sun-screening agent and a stabilizing agent in the macromolecular polyurethane film to 80-90 ℃, mixing and homogenizing, cooling to room temperature, and adding polyurethane dissolved in the other part of water to obtain the polyurethane film.
The application method of the sun-proof moisturizing repair film composition comprises the following steps: and uniformly coating the bionic liquid crystal structure repairing film on the face, uniformly coating the macromolecular polyurethane film on the face after the bionic liquid crystal structure repairing film is completely absorbed, and after the bionic liquid crystal structure repairing film is completely formed.
Example 1
The invention relates to a sun-proof moisturizing repair film composition with a liquid crystal structure, which comprises a bionic liquid crystal structure repair film and a macromolecular polyurethane film;
the bionic liquid crystal structure repairing film comprises the following components in percentage by mass: 6% of an emulsifying agent, 1% of a repairing agent, 10% of a bionic humectant, 13.5% of grease and the balance of water, wherein the sum of the mass percentages of the components is 100%;
the emulsifier is 3% of behenyl alcohol, 2.2% of cetyl alcohol, 0.6% of cetostearyl glucoside and 0.2% of sodium stearyl glutamate;
the repairing agent consists of oligopeptide 0.2%, micromolecular heat shock protein 0.3% and macromolecule recombinant collagen 0.5%.
The bionic humectant comprises 4.05% of glycerin, 0.15% of carbomer, 0.15% of ceramide, 0.15% of sodium hyaluronate with 120-180w molecular weight, 1% of sodium pyrrolidone carboxylate, 3% of amino acid and 1.5% of 1, 2-pentanediol.
The oil consists of 6% of squalane, 6% of olive oil and 1.5% of shea butter;
the macromolecular polyurethane film comprises the following components in percentage by mass: polyurethane-35%, macromolecular sun-screening agent 15%, stabilizer 15%, and water in balance, the sum of the mass percentages of the components being 100%;
the macromolecular sunscreen agent consists of 7% of bis-ethylhexyloxyphenol methoxyphenyl triazine (molecular weight: 727.8), 6% of methylenebis-benzotriazole tetramethylbutylphenol (molecular weight: 658.87) and 2% of ethoxyethyl triazinone (molecular weight: 822);
the stabilizer consists of isopropyl palmitate 7%, cetostearyl alcohol 3%, butanediol 1.8%, glycerol 2%, 1, 2-pentanediol 1% and octanediol 0.2%.
Example 2
The invention relates to a sun-proof moisturizing repair film composition with a liquid crystal structure, which comprises a bionic liquid crystal structure repair film and a macromolecular polyurethane film;
the bionic liquid crystal structure repairing film comprises the following components in percentage by mass: 2% of emulsifying agent, 0.2% of repairing agent, 5% of bionic humectant, 8% of grease and the balance of water, wherein the sum of the mass percentages of the components is 100%;
the emulsifier is 1.4% of behenyl alcohol, 0.4% of cetyl alcohol, 0.1% of cetostearyl glucoside and 0.1% of sodium stearyl glutamate;
the repairing agent consists of oligopeptide 0.04%, small molecular heat shock protein 0.04% and macromolecule recombinant collagen 0.12%.
The bionic humectant comprises 3.1% of glycerin, 0.05% of carbomer, 0.05% of ceramide, 0.05% of sodium hyaluronate with 120-180w molecular weight, 0.25% of sodium pyrrolidone carboxylate, 1% of amino acid and 0.5% of 1, 2-pentanediol.
The grease consists of 8% of squalane;
the macromolecular polyurethane film comprises the following components in percentage by mass: polyurethane-35%, macromolecular sun-screening agent 7%, stabilizer 10%, and water in balance, wherein the sum of the mass percentages of the components is 100%;
the macromolecular sunscreen agent consists of bis-ethylhexyloxyphenol methoxyphenyl triazine (molecular weight: 727.8) 4%, methylenebis-benzotriazole tetramethylbutylphenol (molecular weight: 658.87) 2% and ethoxyethyl triazinone (molecular weight: 822) 1%;
the stabilizer consists of isopropyl palmitate 5.9%, cetostearyl alcohol 1.5%, butanediol 1%, glycerol 1%, 1, 2-pentanediol 0.5% and octanediol 0.1%.
Example 3
The invention relates to a sun-proof moisturizing repair film composition with a liquid crystal structure, which comprises a bionic liquid crystal structure repair film and a macromolecular polyurethane film;
the bionic liquid crystal structure repairing film comprises the following components in percentage by mass: 8% of an emulsifying agent, 2% of a repairing agent, 15% of a bionic humectant, 25% of grease and the balance of water, wherein the sum of the mass percentages of the components is 100%;
the emulsifier is 4% of behenyl alcohol, 3.04% of cetyl alcohol, 0.76% of cetostearyl glucoside and 0.2% of sodium stearyl glutamate;
the repairing agent consists of oligopeptide 0.6%, micromolecular heat shock protein 0.6% and macromolecule recombinant collagen 0.8%.
The bionic humectant consists of 2.4% of glycerin, 0.45% of carbomer, 0.45% of ceramide, 0.45% of sodium hyaluronate with 120-180w molecular weight, 2.25% of sodium pyrrolidone carboxylate, 6% of amino acid and 3% of 1, 2-pentanediol.
The grease consists of 25% of squalane;
the macromolecular polyurethane film comprises the following components in percentage by mass: polyurethane-35%, macromolecular sun-screening agent 25%, stabilizer 20%, and water in balance, the sum of the mass percentages of the components being 100%;
the macromolecular sun-screening agent consists of 9% of bis-ethylhexyloxyphenol methoxyphenyl triazine (molecular weight: 727.8), 9% of methylenebis-benzotriazole tetramethylbutylphenol (molecular weight: 658.87) and 2% of ethoxyethyl triazinone (molecular weight: 822);
the stabilizer consists of 6.6% of isopropyl palmitate, 5% of cetostearyl alcohol, 3% of butanediol, 3% of glycerol, 2% of 1, 2-pentanediol and 0.4% of octanediol.
Comparative example 1
The comparative example provides a composition for a sun protection and moisture protection film, the specific embodiment is the same as example 1, except that the grease is 6% of macadamia nut oil, 6% of jojoba oil and 1.5% of C10-18 fatty acid triglycerides.
Comparative example 2
This comparative example provides a composition for a sun protection, moisturizing and repair film, the specific embodiment being the same as example 1 except that the emulsifier is 2.4% methyl glucose sesquistearate, 1.0% PEG-20 methyl glucose sesquistearate, 2.5% cetylstearyl alcohol.
Comparative example 3
This comparative example provides a composition for a sunscreen moisturizing repair film, the specific embodiment being the same as example 1 except that the sunscreen agent is ethylhexyl methoxycinnamate (molecular weight 290.4) 8%, ethylhexyl salicylate (molecular weight 250.33) 3%, butylmethoxydibenzoylmethane (molecular weight 310.39) 2%, 4-methylbenzylidene camphor (molecular weight 254.37) 2%.
Through experiments, it is found that
Comparative example 1 shows that the type of oil and fat affects the formation of the liquid crystal effect to a different extent than example 1, and the formation of the liquid crystal effect affects the moisturizing effect, the sun-screening effect and the safety.
Comparative example 2 shows that the kind and combination of the emulsifiers have different effects on the formation of the liquid crystal effect, and the formation of the liquid crystal effect is also the moisturizing effect, the sun-screening effect and the safety, as compared with example 1.
Comparative example 3 shows that the kind and molecular weight of the sunscreen agent have a certain influence on the final sunscreen effect and safety of the composition as compared with example 1.
1. Safety test verification
30 volunteers (sensitive muscles) are selected for skin closed patch test, and the selected area is not more than 50mm 2 A plaque test apparatus of about 1mm depth. The test object is placed in the plaque cell in an amount of about 0.020g to about 0.025g (solid or semi-solid) or about 0.020mL to about 0.025mL (liquid). When the test substance is the original cosmetic product, the control hole is blank (no substance is placed), the test substance is diluted sample, the patch test with the test substance is applied to the back or forearm curved side of the subject by using hyposensitization tape, and the patch test is uniformly applied to the skin by using palm light pressure for 24 hours.
Skin reactions were observed according to the criteria of table 1 for 30min (after disappearance of the indentations), 24h and 48h after removal of the subject plaque tester, respectively, and the observations were recorded.
TABLE 1 skin response grading Standard for skin seal Patch test
TABLE 2 Patch test results
As can be seen from table 2 test results nos. 1,2,3 and 8, 9, successful formation of the liquid crystal structure contributes to the final composition safety; 1. as can be seen from nos. 4 and 6, the formation of the liquid crystal structure is less obvious or impossible, and the safety thereof is lowered; 1. it can be seen from figure 8 that the choice of sunscreens has a great impact on the final safety. 4. It can be seen from the numbers 5, 6 and 7 that the formation of the liquid crystal structure is insufficient and has little influence on the final safety, and the safety of the composition depends on the safety of the macromolecular polyurethane film.
The bionic liquid crystal structure repairing film can be obtained according to the whole measurement result, and has a beneficial effect on the whole safety of the composition.
2. Efficacy experiment verification
Determination of SPF value
SPF value test method: the measurement results of the MED test method using a sunlight simulator xenon arc lamp meeting the conditions as a light source are shown in Table 3:
TABLE 3SPF value measurement results
From the measurement results, the formation of the liquid crystal structure plays a role in enhancing the sun-proof effect. The selection and compatibility of the types of sunscreens directly affect the sunscreening effect.
As can be seen from the above SPF measurement experiments, the combined effect of example 1 is higher than that of comparative examples 1,2 and 3. The compositions complement each other, so that the SPF value is improved, and the combination use has the best sun-screening effect.
3. Moisture retention verification
The moisture retention test index is the moisture content of the skin cuticle; skin transepidermal water loss rate. Data and indexes obtained after 30 subjects test examples 1,0h, 2h, 4h, 8h and 12h are shown in tables 4 and 5;
table 4 instrument measurement parameter specification and related apparatus
Table 5 moisturizing efficacy test data
From the test results of table 5, both the moisture growth rate and the percutaneous moisture loss rate of the composition of example 1 were superior to those of comparative examples 1 and 2, and the results of the formation of the bionic liquid crystal structure could directly affect the skin moisturizing effect of the composition.
From the test results of the composition of example 1, the repair film of the bionic liquid crystal structure substrate of example 1 and the macromolecular polyurethane film of example 1, it can be seen that the moisturizing effect of the composition is far better than that of the repair film of the bionic liquid crystal structure substrate and the macromolecular polyurethane film in the moisturizing effect, so that the moisturizing effect is 1+1 & gt2.
4. Clinical efficacy verification of post-sun repair
Selecting male and female 1:1 ratio, and dividing the male and female 1:1 ratio into 30 persons/group (60 groups (control group is blank control); drilling holes with the size of 5cm and 10cm and the diameter of 1.5cm on opaque tin foil rectangular hard paper, and drilling 2 rows and 8 holes on a paperboard; 8 wells were set up as a blank, example 1 composition, example 1 example liquid crystal construction substrate repair film, 1 macromolecular polyurethane film, comparative example 1 composition, comparative example 2 composition, comparative example 3 composition, commercially available after-sun repair product, respectively. The whole experimenter needs to rest for 30min before proceeding. Respectively smearing each group of samples into the holes of the comparison, sticking the drilling paper board on the inner side of the arm after the drilling paper board is completely dried, covering the rest exposed parts of the arm tightly, and irradiating the rest exposed parts in an ultraviolet lamp box, wherein ultraviolet rays only can irradiate the skin of the arm exposed by the holes; the irradiation is continued for 10 minutes after the interval of 5 minutes, the circulation is carried out, and the irradiation time is about 1 hour; the irradiation process experiment is to obtain 6 circular areas damaged by ultraviolet rays to different degrees; after 1 hour, abnormal reactions such as burning and the like are supposed to be caused in the exposed circular area, and the number of people with inflammatory reactions is recorded; the experiment is continuously carried out for 3 days, and the conditions of skin inflammation, peeling, recovery speed and the like are respectively observed and recorded; and then, the skin is continuously smeared for 28 days as a period, the improvement of the pigmentation of the skin is detected by a ANTSCI VISIA skin image analyzer detection system, and one person is recorded when the improvement degree is more than 50%. The clinical test results are shown in Table 6:
TABLE 6 clinical data of human trial efficacy
From the test results of table 6, the quality of the formation of the liquid crystal structures of 2, 5 and 6 directly affects the inflammation relieving and after-sun repairing effects of the composition, and the type and compatibility of the sunscreens of 2 and 6 directly affects the repairing effects. The liquid crystal structure substrate repairing film and the macromolecular polyurethane film can be obtained from the materials 2,3 and 4, and have stronger effects on relieving inflammation (inflammatory reaction generated in 1,2 and 3 hours) generated in real time and repairing for a long time when being used together. It can be seen that the efficacy of the composition is greater than that of the respective film. The efficacy of the anti-inflammatory sun-proof repair is 1+1 & gt2.
Liquid crystal structure test
After 1m of examples 1 and 1 were left at low temperature, the liquid crystal structure was stable as shown in fig. 1 (polarized light microscope X40) and fig. 2 (polarized light microscope X400).
After the comparative example 1 and comparative example 1 were left at a low temperature for 1m, as shown in FIG. 3 (polarization microscope X40) and FIG. 4 (polarization microscope X400), a small amount of liquid crystal structure was present.
After the comparative example 2 and comparative example 2 were left at a low temperature for 1m, as shown in fig. 5 (polarized light microscope X40) and fig. 6 (polarized light microscope X400), the liquid crystal structure was significantly reduced and the structure was changed.
Claims (10)
1. The sun-proof moisturizing repair film composition with the liquid crystal structure is characterized by comprising the following components in percentage by mass: 40-60% of bionic liquid crystal structure repairing film, the balance being macromolecular polyurethane film, the sum of the mass percentages of the components being 100%.
2. The sun-proof moisturizing repair film composition with the liquid crystal structure as claimed in claim 1, wherein the bionic liquid crystal structure repair film comprises the following components in percentage by mass: 2-8% of emulsifying agent, 0.2-2% of repairing agent, 5-15% of bionic humectant, 8-25% of grease and the balance of water, wherein the sum of the mass percentages of the components is 100%.
3. The sun-proof moisturizing repair film composition with a liquid crystal structure according to claim 2, wherein the preparation process of the bionic liquid crystal structure repair film is as follows: heating water and bionic humectant in the bionic liquid crystal structure repairing film to 80-90 ℃, heating emulsifier and grease to 80-90 ℃, mixing and homogenizing the water and the oil at the rotation speed of 5000-8000r/min for 2-4 times, cooling to room temperature, and adding repairing agent to form the repairing film.
4. The composition of claim 2, wherein the emulsifier is any one or more of behenyl alcohol, cetyl alcohol, stearyl alcohol, cetostearyl glucoside, sodium stearyl glutamate, methyl glucsesquistearate, PEG-20 methyl glucsesquistearate, and lecithin.
5. The sun-proof moisturizing repair film composition with a liquid crystal structure as claimed in claim 2, wherein the repair agent comprises the following components in mass percent: 20-30% of oligopeptide, 20-30% of small molecular heat shock protein and the balance of macromolecular recombinant collagen, wherein the sum of the mass percentages of the components is 100%;
the bionic humectant comprises the following components in percentage by mass: 1-3% of carbomer, 1-3% of ceramide, 1-3% of sodium hyaluronate with the molecular weight of 120-180w, 5-15% of pyrrolidone carboxylic acid sodium, 10-20% of 1, 2-pentanediol, 20-40% of amino acid and 16-62% of glycerol as the rest, wherein the sum of the mass percentages of the components is 100%.
6. The sun-proof moisturizing repair film composition with the liquid crystal structure as claimed in claim 1, wherein the macromolecular polyurethane film comprises the following components in percentage by mass: 5-25% of polyurethane, 7-25% of macromolecular sun-screening agent, 10-20% of stabilizing agent and the balance of water, wherein the sum of the mass percentages of the components is 100%.
7. The sunproof moisturizing repair film composition with a liquid crystal structure as set forth in claim 6, wherein the preparation process of the macromolecular polyurethane film is as follows: heating one part of water, macromolecular sun-screening agent and stabilizing agent in the macromolecular polyurethane film to 80-90 ℃, mixing and homogenizing, cooling to room temperature, and adding polyurethane dissolved in the other part of water to obtain the polyurethane film.
8. The sunproof moisturizing repair film composition with liquid crystal structure as set forth in claim 6, wherein the polyurethane is one or more of polyurethanes with polymerization degree of 1,2, 11, 14, 15, 35; the macromolecular sun-screening agent consists of bis-ethylhexyloxyphenol methoxyphenyl triazine, methylenebis-benzotriazole tetramethylbutylphenol and ethoxyethyl triazone.
9. The sun-proof moisturizing repair film composition with a liquid crystal structure as claimed in claim 6, wherein the stabilizer comprises the following components in mass percent: 15-25% of cetostearyl alcohol, 10-15% of butanediol, 10-15% of glycerol, 5-10% of 1, 2-pentanediol, 1-2% of octanediol, and the balance of isopropyl palmitate, wherein the sum of the mass percentages of the components is 100%.
10. The application method of the sun-proof moisturizing repair film composition with the liquid crystal structure is characterized in that the bionic liquid crystal structure repair film is smeared on the face uniformly, after the bionic liquid crystal structure repair film is completely absorbed, the macromolecular polyurethane film is smeared on the face uniformly, and after the bionic liquid crystal structure repair film is completely formed, the bionic liquid crystal structure repair film composition is obtained.
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| CN117122533A (en) * | 2023-08-21 | 2023-11-28 | 广州泰诺生物科技有限公司 | Bionic fetal fat composition and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117122533A (en) * | 2023-08-21 | 2023-11-28 | 广州泰诺生物科技有限公司 | Bionic fetal fat composition and preparation method and application thereof |
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