CN116269200A - Continuous intraocular pressure monitoring sensor and intraocular pressure measuring method - Google Patents
Continuous intraocular pressure monitoring sensor and intraocular pressure measuring method Download PDFInfo
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- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
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- A—HUMAN NECESSITIES
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Abstract
The invention discloses a continuous intraocular pressure monitoring sensor and an intraocular pressure measuring method, wherein the continuous intraocular pressure monitoring sensor comprises an intraocular pressure strain sensing circuit and a wireless transmission circuit which are packaged in a cornea contact lens; the intraocular pressure strain sensing circuit consists of a strain measuring resistor and a temperature compensating resistor and is used for monitoring the change of eyeball curvature caused by the change of intraocular pressure and converting the change into an electric signal; the strain measurement resistor is arranged along the circumferential direction in which the direction of strain is measured; the temperature compensation resistor is arranged along the radial direction in the direction of measuring strain; the temperature compensation of the strain measuring resistor is realized by carrying out difference on the resistance change of the strain measuring resistor and the temperature compensation resistor; the wireless transmission circuit is connected with the strain measurement resistor and the temperature compensation resistor. The continuous intraocular pressure monitoring sensor can complete continuous and real-time monitoring of the intraocular pressure of the patient under the condition that the normal sight of the patient is not affected, is simple to use and convenient to carry, and enables the measurement result to be more accurate.
Description
Technical Field
The invention relates to the technical field of contact lenses, in particular to a continuous intraocular pressure monitoring sensor and an intraocular pressure measuring method.
Background
Glaucoma acts as a global second roughly blind eye disease, and in severe cases, results in irreversible blindness. Related studies have shown that controlling and lowering intraocular pressure in patients is the only available method for treating glaucoma patients. During treatment, the intraocular pressure of the patient needs to be measured to determine whether the treatment is functioning. Since the intraocular pressure of a patient is liable to fluctuate with circadian rhythms while being affected by the body posture of the patient when measuring the intraocular pressure of the patient, the peak value of the intraocular pressure of the patient usually occurs at night or early morning, and long-term and continuous tracking is required to analyze key intraocular pressure fluctuations. Thus, continuous real-time monitoring of the patient's ocular pressure is critical to the patient's treatment.
The current clinical devices for measuring the intraocular pressure of a patient mainly comprise a non-contact tonometer, a Goldmann applanation tonometer, an Icare rebound tonometer and the like, but the devices generally need a trained clinician, cannot realize continuous intraocular pressure detection, and have the defects of inconvenience in carrying, limited measurement precision and the like due to large size, so that key intraocular pressure fluctuation of the patient is difficult to collect. Therefore, there is an urgent need to develop an intraocular pressure monitoring device that is portable, high-precision, and simultaneously can continuously monitor the intraocular pressure of a patient, and is increasingly critical to the treatment of patients.
While invasive sensors allow continuous ocular pressure monitoring, they require surgery, and the implantation process is irreversible, rendering them unacceptable to most patients. Contact lenses are currently the ideal platform for intimate contact with the human eye and have been used as wearable devices for physiological measurements. In recent decades, contact lens IOP (intraocular pressure) sensors have emerged that integrate LC resonant circuits, microfluidic, piezoresistive and photonic crystal technologies. The wireless transmission mode of intraocular pressure data of the non-invasive sensor based on the contact lens mainly comprises optical image comparison, LC resonance frequency measurement and data transmission through an integrated embedded chip. The optical image comparison mode needs an optical reading device, and the optical image comparison mode cannot continuously monitor the intraocular pressure in real time, the capacitance and inductance type sensor needs to measure the resonance frequency to read signals, the frequency or phase discriminator needs to read signals, the detection instrument is large in size and is not beneficial to the patient to carry about, and continuous monitoring of the IOP is difficult to realize clinically.
Unlike optical, LC resonant sensors, data transmission through an integrated embedded chip can be miniaturized, with the sensing mechanism based on resistive sensors. One prior art utilizes silver nanowires as sensors, while integrating wireless circuitry for non-invasive continuous intraocular pressure monitoring, calculates intraocular pressure by measuring the resistance of the silver nanowire sensor as a function of the curvature of the eye, but it does not address the temperature impact on the silver nanowire sensor. The other prior art uses a snakelike silicon-based strain gauge as a sensor, simultaneously integrates an NFC chip for wireless transmission, utilizes a temperature sensor in the NFC chip to acquire temperature data in real time, combines the linear change of the resistance of the silicon-based strain gauge along with the temperature, and corrects the eye pressure by utilizing the temperature data in an acquisition program, but because the temperature sensor in the NFC chip is low in precision, the inside of the chip can generate heat in the use process, accurate temperature data cannot be acquired, and errors still exist after correction. The university of Qinghua Xu Jiandong et al developed a continuous IOP monitoring sensor using a few-layer graphene combined with a wheatstone bridge circuit, which can avoid the influence of temperature, but because it requires two constant value resistors and two measurement resistors to be arranged simultaneously, and the balance of the initial bridge needs to be ensured, and the spatial area of the contact lens is limited, there is much inconvenience in designing the wireless transmission circuit of the integrated embedded chip.
Therefore, in the prior art, the sensing method of continuous intraocular pressure monitoring by a resistive sensor cannot solve the problem of the influence of temperature change on the measurement result.
Disclosure of Invention
Aiming at the urgent need that the current intraocular pressure monitoring equipment cannot meet the continuous and real-time intraocular pressure monitoring of glaucoma patients, the invention provides a continuous intraocular pressure monitoring sensor and an intraocular pressure measuring method, wherein an intraocular pressure strain sensing circuit and a wireless transmission circuit are embedded into a cornea contact lens, so that the continuous and real-time intraocular pressure monitoring of the patients can be completed under the condition that the normal vision of the patients is not influenced, the continuous and real-time intraocular pressure monitoring device is simple to use and convenient to carry, errors caused by the influence of the ambient temperature on a resistance sensor can be avoided more simply, and the measuring result when the patients wear the continuous and real-time intraocular pressure monitoring sensor is more accurate.
The invention adopts the following specific technical scheme:
the invention provides a continuous intraocular pressure monitoring sensor, which comprises a flexible cornea contact lens, an intraocular pressure strain sensing circuit and a wireless transmission circuit, wherein the intraocular pressure strain sensing circuit and the wireless transmission circuit are encapsulated in the cornea contact lens;
the cornea contact lens is in a spherical crown structure and is used for being worn on the eyeball of a patient to be tightly attached to cornea of the eye, so that the accuracy of the intraocular pressure strain sensing circuit sensing is ensured;
the intraocular pressure strain sensing circuit consists of a strain measuring resistor and a temperature compensating resistor and is used for monitoring the change of eyeball curvature caused by the change of intraocular pressure and converting the change into an electric signal; the strain measurement resistor is arranged along the circumferential direction in the direction in which the strain is measured; the temperature compensation resistor is arranged along the radial direction in the direction of measuring strain; the temperature compensation of the strain measuring resistor is realized by differentiating the resistance change of the strain measuring resistor and the temperature compensation resistor;
the wireless transmission circuit is connected with the strain measuring resistor and the temperature compensation resistor, and is used for collecting and processing electric signals obtained by the strain measuring resistor and the temperature compensation resistor and transmitting data to an external receiving device.
Further, the wireless transmission circuit comprises an LC energy supply module, a conductive line, a fixed resistor and an ASIC chip;
the LC energy supply module consists of an antenna coil and a resonance capacitor;
the conductive circuit is used for connecting the antenna coil, the resonance capacitor, the ASIC chip, the fixed value resistor, the strain measurement resistor and the temperature compensation resistor.
Further, the ASIC chip comprises a radio frequency module, a power management module and a digital-to-analog conversion module;
the power management module is connected with the strain measurement resistor, the temperature compensation resistor and the constant value resistor and used for stabilizing and distributing voltage;
the digital-to-analog conversion module is connected with the strain measurement resistor and the temperature compensation resistor and is used for converting an analog signal into a digital signal;
the digital signal transmitting end of the digital-to-analog conversion module is connected with the radio frequency module, and the digital signal is transmitted to an external receiving device through the radio frequency module.
Further, the resistance of the constant value resistor, the resistance of the strain measurement resistor and the resistance of the temperature compensation resistor are all equal;
the ASIC (Application Specific Integrated Circuit) chip is used for calculating the resistance value of the strain measurement resistor by comparing the voltage at the two ends of the constant value resistor and the strain measurement resistor, and calculating the resistance value of the temperature compensation resistor by comparing the voltage at the two ends of the constant value resistor and the temperature compensation resistor.
Further, the diameter of the antenna coil is larger than the diameter of the pupil of the patient;
the antenna coil is made of copper or liquid metal.
Further, the antenna coil is formed by a plurality of inductance coils with spiral structures and is separated from the strain measuring resistor and the temperature compensating resistor in a multi-layer circuit mode;
the antenna coil is die-molded and encapsulated in a layer close to the air.
Furthermore, the cornea contact lens is made of a substrate which has biocompatibility and safety and is made of elastic high-light-transmittance materials;
the intraocular pressure strain sensing circuit and the wireless transmission circuit are both fabricated on the substrate by a microelectronic fabrication process.
Further, the contact lens is made of PDMS (polydimethylsiloxane) or Parylene C (polychloro-paraxylene);
the conductive line is made of liquid metal or copper.
Further, the strain measurement resistor and the temperature compensation resistor are made of nanowire materials or graphene materials, and are continuous serpentine shapes.
Further, the external receiving device comprises a data acquisition device and terminal equipment in signal connection with the data acquisition device;
the terminal device is used for displaying the intraocular pressure value.
In addition, the invention also provides an intraocular pressure measuring method, which comprises the following steps:
measuring initial tonometric value IOP of a patient by tonometer 0 Simultaneously, the continuous intraocular pressure monitoring sensor is worn on the eyeball of a patient, and the resistance value R of the strain measurement resistor is obtained through a wireless transmission circuit a0 Resistance R of temperature compensation resistor b0 ；
When the intraocular pressure changes, the intraocular pressure IOP of the patient at the moment is measured again through the tonometer 1 And the resistance R of the strain measurement resistor is obtained through a wireless transmission circuit a1 Resistance R of temperature compensation resistor b1 ；
Continuous intraocular pressure monitoring of a patient via a contact lens sensor, when the resistance R of the strain gauge resistor is a2 Resistance R of temperature compensation resistor b2 At this time, the intraocular pressure IOP is:
the beneficial effects are that:
the continuous intraocular pressure monitoring sensor is worn on an eyeball of a patient by adopting a flexible cornea contact lens, an intraocular pressure strain sensing circuit and a wireless transmission circuit are packaged in the cornea contact lens, the intraocular pressure strain sensing circuit monitors change of eyeball curvature caused by change of eye pressure through a strain measuring resistor and a temperature compensating resistor and converts the change into an electric signal, the strain measuring resistor is used for circumferentially arranging the direction of measuring strain, the temperature compensating resistor is used for radially arranging the direction of measuring strain, and temperature compensation of the strain measuring resistor is realized by differentiating resistance change of the strain measuring resistor and the temperature compensating resistor; the wireless transmission circuit is used for collecting and processing the electric signals acquired by the strain measuring resistor and the temperature compensating resistor and transmitting the data to an external receiving device; the continuous intraocular pressure monitoring sensor combines cornea deformation characteristics, namely, cornea deformation is mainly circumferential deformation, radial deformation is not obvious, change of eyeball curvature can be well sensed and converted into an electric signal through the strain measuring resistor arranged circumferentially, the temperature compensating resistor arranged along the radial direction in the direction of measuring strain is smaller in change of eyeball curvature, the resistance change mainly comes from temperature change in an external environment, and temperature compensation of the strain measuring resistor is realized by differentiating the resistance change of the strain measuring resistor and the temperature compensating resistor; therefore, the intraocular pressure strain sensing circuit and the wireless transmission circuit are embedded into the cornea contact lens, so that continuous real-time monitoring of the intraocular pressure of a patient can be finished under the condition that the normal sight of the patient is not affected, the intraocular pressure strain sensing circuit is simple to use and convenient to carry, and a method for carrying out temperature compensation on the resistance strain gauge is realized, so that the intraocular pressure strain sensing circuit is more accurate and simpler; meanwhile, errors caused by the influence of the ambient temperature on the resistance sensor can be avoided more simply, and the measurement result is more accurate when the patient wears the resistance sensor.
Drawings
FIG. 1 is a schematic diagram of a continuous intraocular pressure monitoring sensor according to the present invention;
FIG. 2 is a cross-sectional view of section A1-A2 of FIG. 1;
fig. 3 is a schematic diagram of the working principle of the continuous intraocular pressure monitoring sensor according to the present invention.
Wherein, 1-cornea contact lens, 2-antenna coil, 3-conductive circuit, 4-strain measuring resistor, 5-temperature compensating resistor, 6-constant value resistor, 7-ASIC chip, 8-central optical zone, 9-resonance capacitor, 10-eyeball, 11-data acquisition device, 12-terminal equipment, 13-intraocular pressure strain sensing circuit
Detailed Description
The invention will now be described in detail by way of example with reference to the accompanying drawings.
Example 1
The present embodiment provides a continuous intraocular pressure monitoring sensor, as shown in fig. 1, 2 and 3, which includes a flexible contact lens 1, and an intraocular pressure strain sensing circuit 13 and a wireless transmission circuit encapsulated in the contact lens 1;
the cornea contact lens 1 is of a spherical crown structure matched with the eyeball 10 in shape and is used for being worn on the eyeball 10 of a patient to be tightly attached to cornea of the eye, so that the accuracy of sensing by the intraocular pressure strain sensing circuit 13 is ensured;
the intraocular pressure strain sensing circuit 13 is composed of a strain measuring resistor 4 and a temperature compensating resistor 5, and is used for monitoring the change of curvature of the eyeball 10 caused by the change of intraocular pressure and converting the change into an electric signal; the strain gauge resistor 4 is arranged along the circumferential direction in which the strain is measured; the temperature compensation resistor 5 is arranged along the radial direction in the direction in which the strain is measured; the temperature compensation of the strain measurement resistor 4 is realized by carrying out difference on the resistance change of the strain measurement resistor 4 and the temperature compensation resistor 5; the strain measuring resistor 4 and the temperature compensating resistor 5 are made of nanowire materials or graphene materials and are in continuous serpentine shapes;
the wireless transmission circuit is connected with the strain measuring resistor 4 and the temperature compensating resistor 5, and is used for collecting and processing electric signals acquired by the strain measuring resistor 4 and the temperature compensating resistor 5 and transmitting data to an external receiving device; the external receiving device comprises a data acquisition device 11 and a terminal device 12 in signal connection with the data acquisition device 11; the terminal device 12 is used to display the intraocular pressure value, thereby being able to display the intraocular pressure change value.
The continuous intraocular pressure monitoring sensor is worn on an eyeball 10 of a patient by adopting a flexible cornea contact lens 1, an intraocular pressure strain sensing circuit 13 and a wireless transmission circuit are packaged in the cornea contact lens 1, the intraocular pressure strain sensing circuit 13 monitors the change of curvature of the eyeball 10 caused by the change of the intraocular pressure through a strain measuring resistor 4 and a temperature compensating resistor 5 and converts the change into an electric signal, the strain measuring resistor 4 is used for circumferentially arranging the direction of measuring strain, the temperature compensating resistor 5 is used for radially arranging the direction of measuring strain, and the temperature compensation of the strain measuring resistor 4 is realized by differentiating the resistance change of the strain measuring resistor 4 and the temperature compensating resistor 5; the wireless transmission circuit is used for collecting and processing the electric signals acquired by the strain measuring resistor 4 and the temperature compensating resistor 5 and transmitting data to an external receiving device; the continuous intraocular pressure monitoring sensor combines cornea deformation characteristics, namely, cornea deformation is mainly circumferential deformation, radial deformation is not obvious, change of curvature of an eyeball 10 can be well sensed and converted into an electric signal through the strain measuring resistor 4 which is circumferentially arranged, the temperature compensating resistor 5 which is radially arranged along the direction of measuring strain is relatively small in change of curvature of the eyeball 10, and the resistance change is mainly derived from temperature change in an external environment, so that temperature compensation of the strain measuring resistor 4 is realized by differentiating the resistance change of the strain measuring resistor 4 and the temperature compensating resistor 5; therefore, the intraocular pressure strain sensing circuit 13 and the wireless transmission circuit are embedded into the cornea contact lens 1, so that continuous real-time monitoring of the intraocular pressure of a patient can be completed under the condition that the normal sight of the patient is not affected, the intraocular pressure strain sensing circuit is simple to use and convenient to carry, and a method for carrying out temperature compensation on the resistance strain gauge is realized, so that the intraocular pressure strain sensing circuit is more accurate and simpler; meanwhile, errors caused by the influence of the ambient temperature on the resistance sensor can be avoided more simply, and the measurement result is more accurate when the patient wears the resistance sensor.
In a specific embodiment, the wireless transmission circuit comprises an LC energy supply module, a conductive line 3, a fixed resistor 6 and an ASIC chip 7;
the LC energy supply module consists of an antenna coil 2 and a resonance capacitor 9; the diameter of the antenna coil 2 is larger than the diameter of the pupil of the patient; the antenna coil 2 is made of copper or liquid metal; the antenna coil 2 is formed by a plurality of inductance coils with spiral structures and is separated from the strain measuring resistor 4 and the temperature compensating resistor 5 in a multi-layer circuit mode; the antenna coil 2 is encapsulated in a layer close to the air in a mould pressing way; the antenna coil 2 is formed by a plurality of inductance coils with spiral structures, so that the efficient transmission of energy can be satisfied; the antenna coil 2 is separated from the strain measuring resistor 4 and the temperature compensating resistor 5 in a multi-layer circuit mode, so that the influence of the antenna coil 2 on the intraocular pressure strain sensing circuit 13 can be avoided; because the diameter of the antenna coil 2 is larger than that of the pupil of the patient, the antenna coil 2 can be positioned outside the pupil, the light transmission of the central optical zone 8 of the cornea contact lens 1 is ensured, and the antenna coil 2 is prevented from shielding the sight of the patient;
the conductive circuit 3 is used for connecting the antenna coil 2, the resonant capacitor 9, the ASIC chip 7, the fixed value resistor 6, the strain measurement resistor 4 and the temperature compensation resistor 5; the conductive line 3 can be made of liquid metal or copper; the conductive tracks 3 can be prepared by microelectronics technology onto the substrate forming the contact lens 1 for the electrical connection between the individual components;
the ASIC chip 7 comprises a radio frequency module, a power management module and a digital-to-analog conversion module; the power management module is connected with the strain measuring resistor 4, the temperature compensating resistor 5 and the constant value resistor 6 and is used for stabilizing and distributing voltage; the digital-to-analog conversion module is connected with the strain measuring resistor 4 and the temperature compensating resistor 5 and is used for converting an analog signal into a digital signal; the digital signal transmitting end of the digital-to-analog conversion module is connected with the radio frequency module, and the digital signal is transmitted to an external receiving device through the radio frequency module.
Further, the resistance of the constant value resistor 6, the resistance of the strain gauge resistor 4 and the resistance of the temperature compensation resistor 5 are all equal; when the wireless transmission circuit works, the resistance values of the two snake-shaped strain resistors in the intraocular pressure strain sensing circuit 13 can be calculated by comparing the voltage at the two ends of the fixed-value resistor 6 and the two snake-shaped strain resistors; if the constant value resistor with the same resistance value is not provided, a technical scheme that the resistance value of the constant value resistor 6, the resistance value of the strain measurement resistor 4 and the resistance value of the temperature compensation resistor 5 are similar can be adopted, and the purpose that the resistance values are equal or similar is to improve the accuracy of measuring the resistance values of the two snake-shaped strain resistors of the strain measurement resistor 4 and the temperature compensation resistor 5;
the ASIC chip 7 calculates the resistance value of the strain measurement resistor 4 by comparing the voltages at the two ends of the constant value resistor 6 and the strain measurement resistor 4, and calculates the resistance value of the temperature compensation resistor 5 by comparing the voltages at the two ends of the constant value resistor 6 and the temperature compensation resistor 5.
In the continuous intraocular pressure monitoring sensor, the contact lens 1 is made of a substrate which has biocompatibility and safety and is made of elastic high-light-transmittance materials, and the materials are used for packaging the intraocular pressure strain sensing circuit 13 and the wireless transmission circuit, so that the contact lens can perform long-time stable work in a closed environment; the cornea contact lens 1 is made of PDMS or Parylene C; both the intraocular pressure strain sensing circuit 13 and the wireless transmission circuit are fabricated on a substrate by a microelectronic fabrication process.
Example two
The present embodiment provides an intraocular pressure measurement method, which uses the continuous intraocular pressure monitoring sensor in the above embodiment for measurement, and specifically includes the following steps:
measuring initial tonometric value IOP of a patient by tonometer 0 The continuous intraocular pressure monitoring sensor in the above embodiment is worn on the eyeball 10 of the patient to obtain the resistance R of the strain gauge resistor 4 via the wireless transmission circuit a0 Resistance R of temperature compensation resistor 5 b0 The method comprises the steps of carrying out a first treatment on the surface of the When the initial tonometer value of the patient is measured, the measurement can be performed according to a clinical standard protocol;
when the intraocular pressure changes in the elapsed time, the intraocular pressure IOP of the patient at this time is measured again by the tonometer 1 And the resistance R of the strain measuring resistor 4 is obtained through a wireless transmission circuit a1 Resistance R of temperature compensation resistor 5 b1 The method comprises the steps of carrying out a first treatment on the surface of the When the tonometer is adopted to measure the intraocular pressure of the patient again, the same scheme is adopted in the primary measurement, namely, the secondary measurement can be carried out according to a clinical standard scheme;
continuous intraocular pressure monitoring of a patient by means of a contact lens sensor, when the resistance R of the strain gauge resistor 4 is measured a2 Resistance R of temperature compensation resistor 5 b2 At this time, the intraocular pressure IOP is:
by adopting the intraocular pressure measuring method and the continuous intraocular pressure monitoring sensor in the embodiment, the intraocular pressure of the patient can be continuously and real-time monitored under the condition that the normal sight of the patient is not affected, and the problem that the conventional intraocular pressure monitoring equipment cannot meet urgent requirements of continuous and real-time intraocular pressure monitoring of glaucoma patients is solved.
In summary, the above embodiments are only preferred embodiments of the present invention, and are not intended to limit the scope of the present invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A continuous intraocular pressure monitoring sensor comprising a flexible contact lens, an intraocular pressure strain sensing circuit and a wireless transmission circuit encapsulated within the contact lens;
the cornea contact lens is in a spherical crown structure and is used for being worn on the eyeball of a patient to be tightly attached to cornea of the eye, so that the accuracy of the intraocular pressure strain sensing circuit sensing is ensured;
the intraocular pressure strain sensing circuit consists of a strain measuring resistor and a temperature compensating resistor and is used for monitoring the change of eyeball curvature caused by the change of intraocular pressure and converting the change into an electric signal; the strain measurement resistor is arranged along the circumferential direction in the direction in which the strain is measured; the temperature compensation resistor is arranged along the radial direction in the direction of measuring strain; the temperature compensation of the strain measuring resistor is realized by differentiating the resistance change of the strain measuring resistor and the temperature compensation resistor;
the wireless transmission circuit is connected with the strain measuring resistor and the temperature compensation resistor, and is used for collecting and processing electric signals obtained by the strain measuring resistor and the temperature compensation resistor and transmitting data to an external receiving device.
2. The continuous intraocular pressure monitoring sensor of claim 1 wherein said wireless transmission circuit comprises an LC power module, conductive traces, a constant value resistor, and an ASIC chip;
the LC energy supply module consists of an antenna coil and a resonance capacitor;
the conductive circuit is used for connecting the antenna coil, the resonance capacitor, the ASIC chip, the fixed value resistor, the strain measurement resistor and the temperature compensation resistor.
3. The continuous intraocular pressure monitoring sensor of claim 2 wherein said ASIC chip includes a radio frequency module, a power management module and a digital to analog conversion module;
the power management module is connected with the strain measurement resistor, the temperature compensation resistor and the constant value resistor and used for stabilizing and distributing voltage;
the digital-to-analog conversion module is connected with the strain measurement resistor and the temperature compensation resistor and is used for converting an analog signal into a digital signal;
the digital signal transmitting end of the digital-to-analog conversion module is connected with the radio frequency module, and the digital signal is transmitted to an external receiving device through the radio frequency module.
4. A continuous intraocular pressure monitoring sensor according to claim 3 wherein the resistance of said constant value resistor, the resistance of said strain gauge resistor and the resistance of said temperature compensation resistor are all equal;
and the ASIC chip calculates the resistance value of the strain measurement resistor by comparing the voltage at the two ends of the constant value resistor and the strain measurement resistor, and calculates the resistance value of the temperature compensation resistor by comparing the voltage at the two ends of the constant value resistor and the temperature compensation resistor.
5. A continuous intraocular pressure monitoring sensor according to claim 2 wherein the diameter of said antenna coil is greater than the diameter of the patient's pupil;
the antenna coil is made of copper or liquid metal.
6. A continuous intraocular pressure monitoring sensor according to claim 2 wherein said antenna coil is formed of a plurality of inductive coils of helical configuration and is separated from said strain gauge resistor and said temperature compensation resistor by a multi-layer circuit;
the antenna coil is die-molded and encapsulated in a layer close to the air.
7. A continuous intraocular pressure monitoring sensor according to claim 2 wherein said contact lens is made of a substrate of a highly light transmissive material that is both biocompatible and safe and resilient;
the intraocular pressure strain sensing circuit and the wireless transmission circuit are both fabricated on the substrate by a microelectronic fabrication process.
8. The continuous intraocular pressure monitoring sensor of claim 7 wherein said contact lens is made of PDMS or Parylene C;
the conductive line is made of liquid metal or copper.
9. The continuous intraocular pressure monitoring sensor of claim 1 wherein said strain gauge resistor and said temperature compensating resistor are each made of nanowire material or graphene material and are each continuous serpentine in shape;
the external receiving device comprises a data acquisition device and terminal equipment in signal connection with the data acquisition device;
the terminal device is used for displaying the intraocular pressure value.
10. A method of tonometry, comprising the steps of:
measuring initial tonometric value IOP of a patient by tonometer 0 Simultaneously, the continuous intraocular pressure monitoring sensor according to any one of claims 1 to 9 is worn on the eyeball of a patient, and the resistance R of the strain measurement resistor is obtained through a wireless transmission circuit a0 Resistance R of temperature compensation resistor b0 ；
When the intraocular pressure changes, the intraocular pressure IOP of the patient at the moment is measured again through the tonometer 1 And transmitting electricity by radioObtaining the resistance value R of the strain measurement resistor at the moment a1 Resistance R of temperature compensation resistor b1 ；
Continuous intraocular pressure monitoring of a patient via a contact lens sensor, when the resistance R of the strain gauge resistor is a2 Resistance R of temperature compensation resistor b2 At this time, the intraocular pressure IOP is:
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