CN1162271A - Dosimetric spacer - Google Patents
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- CN1162271A CN1162271A CN 95195916 CN95195916A CN1162271A CN 1162271 A CN1162271 A CN 1162271A CN 95195916 CN95195916 CN 95195916 CN 95195916 A CN95195916 A CN 95195916A CN 1162271 A CN1162271 A CN 1162271A
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Abstract
An apparatus for administering a fluid medicament to a patient in a gas for inhalation and for calculating the dosage administered to the patient comprising a holding member (1) for temporarily holding the medicament and gas prior to inhalation, means for introducing a quantity of the medicament into the holding chamber (1), a sensor (4) for detecting the introduction of the medicament into the holding chamber (1), detector means for detecting the rate of flow of gas inhaled by a patient from the holding chamber (1) and calculation means (25,27,29,30,31) operably connected to the sensor (4) and to the detector means for calculating the amount of medicament received by a patient. The calculating means (25,27,29,30,31) makes its calculation on the basis of the quantity of medicament released into the holding chamber (1), the volume of the holding chamber (1), the time elapsed from the detection of the introduction of the medicament, and the detected rate of flow of gas inhaled from the holding chamber (1). The calculation being made by assessing the concentration of the medicament in the holding chamber (1) on a time basis during reduction of the said concentration within the holding chamber (1), and by determining the volume of the gas received by the patient during inhalation, and the time elapsed from the detected introduction of medicament to the inhalation by the patient.
Description
The present invention relates to a kind ofly in the gas that patients sucks, add the method and apparatus that a kind of quantitative fluid medicine is used.
In this description and claims, but the powder of the fluid medicine liquid of indication or fluidisation attitude or other similar forms.
As everyone knows, the multi-dose inhaler (MDI) by patient's operation has the mask that a patient uses by its suction gas or medicine.When patient begins to smoke, must start this MDI, make at the medicine that will measure dosage by patient by mask when air-breathing to be sprayed onto in the air flow.
It's a pity that above-mentioned MDI often loses a lot of medicines because of misoperation.This MDI must be activated when air-breathing or cause in that patient is firm, around the pulmonary that medicine can be inhaled into can make it to play effectiveness.If this NDI fixes too lately, most drug rests on bottleneck throat or bronchus and is invalid.Elderly patients and child can not make the initiation of MDI probably and begin air-breathing mutual coordination.
More existing MDI and Diskus (DPI) are available, and they comprise that some survey patients whether just air-breathing and start the pick off of MDI automatically.Although these MDI and DPI work finely when surveying the air-breathing beginning of adult, concerning old people and child, start MDI and just have any problem, can not be measured because their inspiratory flow rate is too little.Usually be, when this inspiratory flow rate that just occurs in them reaches its maximum, therefore, to start MDI and also just be filled half generation at patient's lung if a child or old people can start MDI.
Once the someone proposed to have a separator chamber or a preserving chamber that links to each other with MDI or DPI.When MDI is activated, at full speed cause the medicine of a certain dosage from respiratory organ.If patient directly sucks the medicine of this dosage, because suction velocity is higher, the medicine of most of dosage is punched in the back of throat.And many these medicines of medicine no show will be at the pulmonary of treatment.In some cases, the medicine of fewer than half dosage is stayed in the lung.The particular problem that the child directly sucks medicine is, because the volume of child's lung is less, therefore the medicine of all dosage of emitting can not be sucked.Preserving chamber is arranged between MDI and the patient.Medicine is directed onto in this preserving chamber, and medicine just is placed on that this is indoor before patient sucks from this preserving chamber.The separator chamber absorbs from the high-speed of the medicine of MDI initiation plays the effect of one " buffering " chamber.Then, suck with a much lower speed by patient.Like this, the medication amount of beating at the throat back is reduced more than 80 percent, the amount of staying pulmonary can be doubled.
In addition, the use of preserving chamber means after medicine has been initiated in the preserving chamber, and patient just no longer needs to coordinate the initiation of medicine and its relation between air-breathing.
Some shortcoming of the thing of above-mentioned proposition.In fact really be deep into patient's pulmonary although can not accomplish to assure the medicine of a specified rate, but still wish to guarantee to medication amount as far as possible accurately, make patient's treatment in full force and effect.
In the past, the medicine of a certain dosage is directed onto in the preserving chamber, repeats air-breathing when the medicine of concluding all dosage is inhaled into from this preserving chamber patient.Like this to being accurately by the estimator of the drug dose of the actual suction of patient.At first, air-breathing along with patient, more air is inhaled in this preserving chamber, to replace the air of being inhaled.This makes the medicine in the preserving chamber diluted.So even work as a patient inhales two to three times, medicine is still stayed in this preserving chamber.Secondly, be injected to medicine in the preserving chamber and fall wall and bottom in the meantime gradually at preserving chamber.This part is owing to gravity causes, and part is because on the medicine and the cause of the electrostatic charge in the preserving chamber.Therefore, in intake period, many medicines are not fed to patient, no matter and the patient inhales number of times what.
The objective of the invention is to, reduce above-mentioned and other shortcoming, particularly will accurately determine the medication amount that is sucked by patient.
Protection scope of the present invention is limited by appended claim.
By example all embodiment of the present invention are described in conjunction with some accompanying drawings now.Accompanying drawing wherein is:
Fig. 1 and 2 represents the first embodiment of the present invention;
Fig. 3 expresses drug concentrations in the curve chart mode and how to change;
The variation of dilution factor when Fig. 4 is illustrated in the suction medicine with the curve chart form;
Fig. 5 is the curve chart of expression by the flow of pick off;
The Fig. 6 and the 7 expression second embodiment of the present invention;
Fig. 8,9 and 10 is curve charts of the feature of expression second embodiment;
The Figure 11 and the 12 expression third embodiment of the present invention;
Figure 13 represents the fourth embodiment of the present invention;
Figure 14 is the air that detected by pick off of expression or the curve chart of gas flow;
Figure 15 has represented the processor layout that a drug dose that calculates the supply patient is used; And
Figure 16 represents the another embodiment that comprises control system of the present invention.
See Fig. 1 earlier.One preserving chamber 1 comprises an inlet 2, feeds this preserving chamber by this inlet liquid medicine from multiple dose respiratory organ (MDI) 3.MDI3 discharges liquid medicine with drop group (a cloud of dropplet) form.Be provided with a pick off 4 between MDI3 and preserving chamber 1, it surveys each startup of MDI3.This pick off 4 is gone back detecting air or other gas by 2 flowing velocities that enter this preserving chamber 1 that enter the mouth.
This preserving chamber comprises that also one is connected with the outlet 5 of a mask 6.Patient sucks air or the gas that has been full of from the medicine of preserving chamber 1 from mask 6.This makes more air or gas be drawn into this preserving chamber 1 through inlet 2.Air is surveyed by pick off 4 by the flow velocity of inlet.Be provided with a check valve 7 between outlet 5 and mask 6, like this, patient can only be from preserving chamber 1 suction and in this preserving chamber of can not breathing out.The mask 6 of before patient exhales, must moving away.
See Fig. 2.In mask 6, be provided with one second check valve 8, the air of breathing out can be discharged in the surrounding air by this valve.
In case medicine is released in the preserving chamber, at first because gravity and preserve locular wall and medicine between the cause of electrostatic force, drug concentrations will be fallen to make drug deposition and reduce on the wall of preserving chamber and bottom along with medicine.Secondly, cause dilution, concentration is reduced owing to the air admission preserving chamber has replaced by patient's inhaled air.
Dosage for the medicine of determining the effective supply patient must calculate.Do these calculating, will understand more following feelings information earlier:
(A) drug concentrations in preserving chamber 1 (as shown in Figure 3).This concentration value depend on MDI that drug release is used in the preserving chamber in the meantime the number of starts and had drug deposition by oneself and risen at medicine to the release of preserving chamber and the time quantum between the patient inhales; And
(B) dilution factor, promptly because the air or the gas that do not contain medicine do not enter preserving chamber 1, so, when the drug level of 1 li of preserving chamber of the every suction of patient just is lowered once.This dilution information slip is shown in Fig. 4.
According to these information, but the drug dose that monitor patients is received when the medication amount of supplying with patient is an aequum, has a device can send shows signal, and as seen this signal maybe can be heard.
See Fig. 5, the type of flow of the inlet that passes through preserving chamber 12 that its expression detects.After MDI starts, just begin treatment, survey patient's air-breathing situation since then patient.Survey gettering rate, make and to calculate to determine having reached required dosage when.Point out this time point then.
Calculating to the dosage of giving patient is described now in conjunction with embodiment shown in Figure 2.Patient is connected in MDI3 inlet 2 earlier.Start MDI3 then so that (a cloud of) medicine is discharged in the preserving chamber 1 by pick off 4.The pick off 4 that can be a mike or pressure detector is surveyed the input of medicine to preserving chamber 1, and sends a signal.One data processor (not shown) receives from the signal of pick off 4 and startup-timer (not shown).Then, patient is with mask 6 and is air-breathing.Air that preserving chamber is 1 li and medicine from preserving chamber by export 5 and mask be inhaled into.Meanwhile, air 2 enters preserving chamber 1 replacing inhaled air by entering the mouth, thereby causes dilution.Data processor calculates the medication amount of supplying with patient with the frequent interval that is generally per second 100 times.In each time cycle of selecting for use like this, calculate in the preserving chamber 1 drug level with take into account medicine in the meantime on the wall of preserving chamber 1 deposition and enter preserving chamber 1, not with the diluting effect of the air of any medicine.One bin comprises data and consults platform, is used to refer to a certain moment after medicine is sent into according to the drug concentrations of deposition velocity in preserving chamber of medicine.This bin also includes data and consults platform, is provided to show behind the air of input one set amount in the preserving chamber drug concentrations.So, in the time of selecting for use, calculate the drug level in the preserving chamber 1.Then, can calculate the drug dose of suction like this, the air capacity that is soon recorded by pick off in the time cycle of selecting for use multiply by in the time cycle that is selected for use that the drug level in the preserving chamber is resulting long-pendingly promptly to be.After this, the dosage addition of calculating gained in the dosage that will in the time cycle that this is selected for use, calculate and time cycle of selecting for use more in front.In case this cumulative accumulated dose arrives a predetermined value, will demonstrate the medicine that given all dosage to patient.Available light of this demonstration or acoustical signal.Patient needed the gas of taking a few mouthfuls of it before sucking predetermined close.Because check valve 8 can be discharged to the gas of breathing out in the ambient air, but patient just through port cover on per twice and exhale between air-breathing.
Microprocessor also must calculate the startup of MDI or cause number of times, so that calculate the initial drug level in the preserving chamber 1.The accountant of usefulness is similar to will be in conjunction with Figure 15 and 16 those devices of describing in the back of this description in the present embodiment.But, in the present embodiment, except considering because the reduction of the concentration that the deposition of medicine causes also will be considered the influence of diluting.
Refer now to Fig. 6.Another device that the figure shows is worked in conjunction with dry powder respiratory organ (DPI).DPI is normally started by patient's inspiratory airflow.They do not fit into the very low patient of inspiratory airflow, because DPI may not necessarily be triggered reliably.The dry powder respiratory organ discharges by patient and sucks the medicine that is fine-powdered in their lung.The same with traditional MDI, the shortcoming of traditional DPI is that the medicine of most given doses hits the back side at patient's bottleneck throat.According to Fig. 6, a preserving chamber 1 comprises one first inlet 9, and it is used for to this preserving chamber 1 application of load and removes load.This preserving chamber 1 also comprise one in chamber 1 piston mobile 10.When this piston 10 pulls back, through first mouthful 9 air or gas are sucked in the preserving chamber 1, and the air that is trapped in the piston back is released by one second mouthful 11.
This preserving chamber 1 comprises a check valve 12, this valve only when piston 10 pulls back foot just with the gas or the air communication that add with medicine.This check valve 12 makes air can only flow into surge chamber.
In use, piston 10 is pulled back so that air or gas suck in this preserving chamber 1 through first mouthful 9.Air or gas are used for Diskus 13 and the pick off 4 of drug release to air or gas by one earlier before arriving first mouthful 9.In case piston 10 pulls back foot, it just makes this check valve 12 expose.Piston 10 just is initiated in that position.Then, patient moves DPI13 away and changes a mask 6 (as shown in Figure 7).Then, patient is air-breathing from mask 6, air that adds in company with medicine or gas through mouthfuls 9, pick off 4 and mask 6 be inhaled into from preserving chamber.Pick off 4 is surveyed this air flow (as shown in figure 10) surrounding air and is entered surge chamber 1 through check valve 12, so that replace air or the gas that just is being inhaled into.
Can do also to calculate when medicine has been added to a given dose accurately to measure.In addition, must understand the drug concentrations (as shown in Figure 8) in the preserving chamber 1, because the deposition of medicine is arranged in the meantime.Also must understand dilution factor (as shown in Figure 9) in intake period.As described in conjunction with Figure 2, can calculate these contents from the output of pick off 4.
In case supplied with dosage accurately, just sent indication.
Figure 11 and 12 has represented another embodiment.In this embodiment, piston 10 returns and crosses preserving chamber 1 when patient inhales.In preserving chamber, there is not check valve 12 as in the previous examples.In the process of soaring of air-breathing and afterwards preserving chamber 1, thereby this piston can only move along the direction of the preserving chamber 1 that soars and prevents dilution.For patient can be exhaled, a check valve 14 is set in mask 6.
Another advantage of this embodiment is, has eliminated dilution factor, and makes Rapid Dose Calculation simpler, quick and accurate.This preserving chamber 1 of no air admission is to replace air or the gas that just is being inhaled into, and this is to replace the air that has been inhaled into because this piston moves.
Now in conjunction with the calculating of the description of the embodiment shown in Figure 11 and 12 to supply patient's dosage.Patient at first links DPI13 on the mouth 19.Pulling back piston 10 makes air be inhaled in the preserving chamber 1 through DPI13 and mouth 9.The pick off 4 that can be a mike or a pressure detector is being surveyed the input of medicine to preserving chamber 1, and produces a signal.One data processor (not shown) receives the signal from pick off 4, and starts a timer (not shown).Patient moves DPI and changes a mask (Figure 12) from mouth 9 then.Patient is air-breathing by this mask, air flow flows through sensor 4.Data processor calculates the drug dose of giving patient very continually, and common every centisecond calculates once.Drug level in preserving chamber 1 is calculated continuously, and considers the deposition of medicine on the wall of preserving chamber 1 in the meantime.One bin includes data and consults platform, is provided to show the drug concentrations that is engraved in when input a certain behind the medicine in the preserving chamber 1.Then, can calculate the dosage that sucks medicine like this, be about to the air capacity that recorded by pick off, multiply by that drug level is resulting long-pendingly promptly to be.Then, will be in selecting for use of this centisecond dosage that calculates in the time cycle and the dosage addition of selecting calculating gained in the time cycle more in front for use.In case this cumulative accumulated dose reaches a predetermined value, will demonstrate the medicine that has given all dosage to patient.Available light of this demonstration or acoustical signal.
Figure 15 comprises a schematic diagram by the processor system of the processor 25 of a power supply 34 power supply.It is when medicine to be sent into speed in the preserving chamber 1 and patient inhales to indicate that pick off 4 is given this processor 25 with all signals by an amplifier 32.This processor 25 is to calculate the drug dose of supplying with patient on a program 29, comprises the basis of the bin 30 of data consultation device 31 and clock and watch 27.When in case this processor calculates the supply dosage that reaches predetermined, just by data output 33 outputs one signal.
See Figure 13 and 14 now.Whole system is controlled by moving of piston 10.Do not use valve, but mask comprises two inlets, a logical atmosphere, another logical preserving chamber 1.Pick off 4 surveys when patient is just exhaling and be air-breathing.Piston 10 moves forward automatically when patient inhales, makes this patient suck air or the gas that contains medicine from preserving chamber 1.As several embodiment of front, when receiving the medicine of correct dose, patient to send the alerting signal that to listen or to see.
In this embodiment, make in case piston pulled out to be full of medicine and air in the preserving chamber 1, available biasing device this piston of setovering, thus air and medicine are released preserving chamber 1, other has locking device to be used for fixing piston.Pick off 4 is pick offs of a kind of generation usefulness of sensing patient inhales, stopped air-breathing in case pick off 4 detects patient, before the locking device fixed piston, microprocessor 25 release locking devices make piston move through preserving chamber 1, so that distribute enough air and medicine to be satisfied with patient's suction.When patient exhales, the gas of exhalation is drained by the check valve on the mask 14.Breathing process will repeat to determine that up to microprocessor patient has received pre-metered doses of medication, and patient will be alerted this moment, and locking device is fixed piston securely and made no longer and can be drawn onto medicine from preserving chamber 1.
In an embodiment more as shown in figure 16, a piston 10 removable preserving chambers 1 that pass through, this preserving chamber 1 have flatly 9, can be drawn into air or medicine from a DPI through this mouth 9 when piston 10 is drawn.Patient draws a connecting rod 20 just can pull out piston 10.Be with tooth on this connecting rod 20, an electromagnetism ratchet 21 be arranged on preserving chamber 1 in appearance to be meshed and lock piston 10 with toothed connecting rod 20.Other have a random spring 22 round connecting rod 20 and be arranged on piston 10 and an end of preserving chamber 1 between, this spring is biased in piston 10 to drain gas and medicine from preserving chamber 1.In addition, also comprise potion template 35, be used to refer to the dosage of having supplied with in accordance with regulations.The operation of present embodiment is identical with shown in Figure 11,12 and 15 substantially, and the dosage that gives patient is wherein monitored all the time.Processor 25 uses signal from pick off 4, from the time signal of an intervalometer 27, to consult about the data of predetermined close and data on the platform be time dependent data how about drug level.Along with the increase of the dosage that gives patient that calculates, just luminous with the pipe of the ratio corresponding position of given predetermined close in all light emitting diodes on the dosage plate 35, this moment, new light emitting diode everywhere respectively can be luminous 25%, 50%, 75% and 100%.In addition, when having supplied with whole pre-metered doses of medication, microprocessor 25 drive electromagnetism ratchet 21 to be engaged in toothed connecting rod 20 lock piston 10.Like this, just can prevent has medicine to be fed to patient again.Microprocessor system also comprises a compliance data storage (compliance data memory) 36, is used for the dosage of record date, time and output, and these data then can be analyzed by the doctor.
Data above-mentioned are consulted platform and can be provided about drug concentrations and how to reduce in time, and drug concentrations is how by the air-breathing data that dilution reduced that causes because of known quantity.The data of consulting in the platform must be by the test accumulation.For example, when collecting the data that reduce in time about drug level, the medicine of a known quantity is sent into preserving chamber 1, and the air in the preserving chamber 1 is discharged into a filter paper through behind the certain hour.Then the medicine that is discharged from is weighed.To repeat to do this test by the different time cycles to set up data necessary.Concentration curve over time may be different for different medicines.Therefore, device must have its correct scatter chart that designs.
Be input in the preserving chamber by medicine, replace some air again, then air and medicine are entered a filter paper, just can collect the data that reduce because of dilution about drug level with the diluent substrate concentration with a known quantity.A curve then just can draw.
Usually, the volume of preserving chamber 1 generally is the 100-500 milliliter, and pick off 4 can be a pressure-type, as a kind of air operated, or turbulent flow-detecting, as a mike.
Claims (23)
1. the apparatus that gas that invalid fluid medicine adding is smoked, and calculating is given patient's dosage comprises:
One preserving chamber is used for temporarily preserving medicine and gas before being sucked by patient;
A certain amount of medicine is sent into the device that preserving chamber is used;
One pick off is used for the input of sensing medicine to preserving chamber;
Sniffer is used for surveying the flow velocity of patient from the gas of preserving chamber suction; And
Accountant, it is operably connected to pick off and sniffer, is used for the medication amount that absorbed by patient according to following data computation: be discharged into the predetermined medication amount in the preserving chamber; The volume that presets of preserving chamber; In the past time when sensing the input of medicine; And, the flow velocity of the gas that is detected, suck from preserving chamber;
By being at least a portion because the estimation of the time-based drug level in the preserving chamber during the reduction of the drug level in the preserving chamber that causes of the deposition of medicine in preserving chamber, and, to the gas flow that absorbed by patient in intake period with from sensing the mensuration that is input to patient inhales institute elapsed time of medicine, just can make aforementioned calculation.
2. the apparatus that gas that invalid fluid medicine adding is smoked, and calculating is given patient's dosage comprises:
One preserving chamber is used for preserving medicine and gas before being sucked by patient;
A certain amount of medicine is sent into the device that preserving chamber is used;
One pick off is used for the input of sensing medicine to preserving chamber;
Sniffer is used for surveying the flow velocity of patient from the gas of preserving chamber suction; And
Accountant, it is operably connected to pick off and sniffer, is used for calculating the medication amount that is absorbed by patient, and this accountant comprises:
One time set is used to refer to when the autobiography sensor senses medicine input preserving chamber and rises the time in the past;
And then the device of the initial drug level in the holding chamber in preserving chamber input medicine is provided;
Be determined at the device of the drug level in the preserving chamber during the patient inhales, drug level reduction at least a portion in time is owing to the deposition of medicine in preserving chamber causes, and this mensuration is to play the time in past when sensing medicine input preserving chamber according to the initial concentration that is provided by the device that initial concentration is provided and according to the self-inductance measurement device to carry out; And
The device that the medication amount that mensuration is absorbed by patient is used, this mensuration is undertaken by following method: earlier to by detection to flow velocity carry out integration and calculate the gas flow that is sucked from preserving chamber by patient, then, the gas flow of trying to achieve aforementioned calculation amasss with the drug level in the preserving chamber of that time of being measured by the device of measuring drug level is.
3. apparatus as claimed in claim 1 or 2 is characterized in that, also comprises a bin, is used for depositing one and consults chart, and this graphical presentation is the reduction situation of the interior drug level of preserving chamber in the meantime.
4. apparatus as claimed in claim 3 is characterized in that, the mensuration work that is determined at the device that the drug level in the intake period preserving chamber uses is also carried out according to the chart of consulting in the bin.
5. as each described apparatus in the claim 2,3 or 4, it is characterized in that, the device that provides and then the initial drug level in the holding chamber in preserving chamber input medicine to use is measured described initial concentration according to the drug level of the input preserving chamber of scheduled volume and the predetermined volume of preserving chamber.
6. as each described apparatus in above-mentioned all claim, it is characterized in that, preserving chamber comprises an inlet, and this inlet can be in patient inhales and from the preserving chamber gas bleeding, makes gas enter preserving chamber thereby cause when making the reduction of drug level in the preserving chamber because of dilution.
7. apparatus as claimed in claim 6 is characterized in that, the mensuration work that is determined at the device that the drug level in the intake period preserving chamber uses is also undertaken by the gas flow that patient sucks according to the front.
8. as claim 6 or 7 described apparatuses, it is characterized in that, also comprise a bin, be used for depositing one and consult chart, the situation that drug level reduces with the air capacity that is inhaled in this graphical presentation preserving chamber.
9. as each described apparatus in the claim 1 to 5, it is characterized in that preserving chamber comprises a piston, when air-breathing, reduce gas flow in preserving chamber, thereby prevent diluted with its.
10. apparatus as claimed in claim 9 is characterized in that, also comprises the device that lock piston is used.
11., it is characterized in that piston can move so that gas and medicine are sucked preserving chamber as claim 9 or 10 described apparatuses in preserving chamber.
12. as above-mentioned all claim in each described apparatus, it is characterized in that, also comprise one in preserving chamber the mouth, a certain amount of medicine is sent in the preserving chamber by described releasing device by this mouth, and, suck gas by this stomatosis people.
13., it is characterized in that the plunger lock device pins piston as each described apparatus in the claim 10 to 12 when the dosage that records is provided.
14. apparatus as claimed in claim 1 is characterized in that, also comprises the device that indication provides the dosage that records to use.
15., it is characterized in that medicine is a drop group as each described apparatus in above-mentioned all claim.
16., it is characterized in that medicine is a dry powder particle as each described apparatus in above-mentioned all claim.
17. as each described apparatus in above-mentioned all claim, it is characterized in that preserving chamber comprises and being sucked away by the gas in this mouthful preserving chamber flatly, and, by this mouthful drug release in preserving chamber.
18. as each described apparatus in above-mentioned all claim, it is characterized in that, be used for the sensing medicine to the pick off of the input usefulness of preserving chamber be used for surveying the sniffer that the flow velocity of the gas that patient sucks from preserving chamber uses and form by a single-sensor.
19. apparatus as claimed in claim 18 is characterized in that, single-sensor is arranged on the mouth place of preserving chamber.
20. one kind adds the gas that smokes with invalid fluid medicine, and the apparatus that calculates the dosage of giving patient comprises:
One preserving chamber is used for temporarily preserving medicine and gas before being sucked by patient;
A certain amount of medicine is sent into the device that preserving chamber is used;
One pick off is used for the input of sensing medicine to preserving chamber;
Sniffer is used for surveying the flow velocity of patient from the gas of preserving chamber suction; And
Accountant, it is operably connected to pick off and sniffer, is used for the medication amount that absorbed by patient according to following data computation: be discharged into the predetermined medication amount in the preserving chamber; The volume that presets of preserving chamber; In the past time when sensing the input of medicine; And, the flow velocity of the gas that is detected, suck from preserving chamber;
By at least a portion be since the reduction of medicine described concentration in the diluted preserving chamber that causes in preserving chamber during, the estimation of the drug level in the preserving chamber of doing according to the amount that is inhaled into that detects, and, just can make aforementioned calculation to the mensuration of the gas flow that absorbed by patient in intake period.
21. one kind adds the gas that smokes with invalid fluid medicine, and the apparatus that calculates the dosage of giving patient comprises:
One preserving chamber is used for preserving medicine and gas before being sucked by patient;
A certain amount of medicine is sent into the device that preserving chamber is used;
One pick off is used for the input of sensing medicine to preserving chamber;
Sniffer is used for surveying the flow velocity of patient from the gas of preserving chamber suction; And
Accountant, it is operably connected to pick off and sniffer, is used for calculating the medication amount that is absorbed by patient, and this accountant comprises:
One time set is used to refer to when the autobiography sensor senses medicine input preserving chamber and rises the time in the past;
The device that provides and then the initial drug level in the holding chamber in preserving chamber input medicine to use;
Be determined at the device of the drug level in the preserving chamber during the patient inhales, drug level with by reduction at least a portion of the gas flow inhaled owing to medicine diluted causing in preserving chamber, this mensuration is to sense the gas flow that plays, calculates from the gas flow rate that is recorded by detector the suction of gained when medicine is imported preserving chamber according to the initial concentration that is provided by the device that initial concentration is provided and self-inductance measurement device to carry out; And
The device that the medication amount that mensuration is absorbed by patient is used, this mensuration is undertaken by following method: earlier to by detection to flow velocity carry out integration and calculate the gas flow that is sucked from preserving chamber by patient, then, the gas flow of trying to achieve aforementioned calculation amasss with the drug level in the preserving chamber of that time of being measured by the device of measuring drug level is.
22. one kind is used an apparatus to be added the method for the gas that smokes with invalid by the fluid medicine of dose, this apparatus comprises:
One preserving chamber is used for preserving medicine and gas before being sucked by patient;
A certain amount of medicine is sent into the device that preserving chamber is used;
One pick off is used for the defeated people of sensing medicine to preserving chamber;
Sniffer is used for surveying the flow velocity of patient from the gas of preserving chamber suction; And
Accountant, it is operably connected to pick off and sniffer, is used for calculating the medication amount that is absorbed by patient;
This method comprises the following steps:
In the moment of sensing medicine input preserving chamber, this sensing is surveyed by pick off;
Monitoring elapsed time in the input that detects medicine, this monitoring is undertaken by accountant;
Be determined at the drug level in the preserving chamber during the patient inhales, drug level reduction at least a portion in time is owing to the deposition of medicine in preserving chamber causes, and this mensuration is according to the initial concentration that provides and elapsed time when sensing from medicine input preserving chamber from sensor;
The medication amount that mensuration is absorbed by patient, this mensuration is undertaken by following method: earlier to by detection to flow velocity carry out integral and calculating, calculate the gas flow that is sucked from preserving chamber by patient again, then, it is long-pending to try to achieve the gas flow and the drug level in that preserving chamber that records for the moment of aforementioned calculation.
23. one kind adds the gas that smokes with invalid fluid medicine, and the method for calculating the dosage of giving patient comprises the steps:
The moment of a certain amount of medicine input of sensing preserving chamber;
Survey the flow velocity of patient from the gas of preserving chamber suction;
Monitoring elapsed time in the input that detects medicine;
Be determined at the drug level in the preserving chamber during the patient inhales, drug level reduction at least a portion in time is owing to the deposition of medicine in preserving chamber causes, this mensuration be according to the initial drug level in the predetermined preserving chamber in the input of the medicine and then preserving chamber and when sensor senses medicine input preserving chamber elapsed time;
The medication amount that calculating is absorbed by patient, this calculating is undertaken by following method: earlier the flow velocity of surveying is carried out integral and calculating, calculate the gas flow that is sucked from preserving chamber by patient again, then, it is long-pending to try to achieve the suction gas flow and the drug level in that preserving chamber that records for the moment of aforementioned calculation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95195916 CN1162271A (en) | 1994-10-27 | 1995-10-27 | Dosimetric spacer |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9421687.6 | 1994-10-27 | ||
| CN 95195916 CN1162271A (en) | 1994-10-27 | 1995-10-27 | Dosimetric spacer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1162271A true CN1162271A (en) | 1997-10-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 95195916 Pending CN1162271A (en) | 1994-10-27 | 1995-10-27 | Dosimetric spacer |
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| Country | Link |
|---|---|
| CN (1) | CN1162271A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020173595A1 (en) | 2019-02-27 | 2020-09-03 | NuvoAir AB | A method and a device for estimating an amount of a powder shaped material passing a bend in a flow channel |
| CN111973848A (en) * | 2020-07-13 | 2020-11-24 | 四川省人民医院 | Inhalant device |
-
1995
- 1995-10-27 CN CN 95195916 patent/CN1162271A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020173595A1 (en) | 2019-02-27 | 2020-09-03 | NuvoAir AB | A method and a device for estimating an amount of a powder shaped material passing a bend in a flow channel |
| CN111973848A (en) * | 2020-07-13 | 2020-11-24 | 四川省人民医院 | Inhalant device |
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