CN116212764A - Method for industrially synthesizing 2, 2-diphenyl ethanol by using continuous flow equipment - Google Patents
Method for industrially synthesizing 2, 2-diphenyl ethanol by using continuous flow equipment Download PDFInfo
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- NYLOEXLAXYHOHH-UHFFFAOYSA-N 2,2-diphenylethanol Chemical compound C=1C=CC=CC=1C(CO)C1=CC=CC=C1 NYLOEXLAXYHOHH-UHFFFAOYSA-N 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims abstract description 23
- 230000002194 synthesizing effect Effects 0.000 title claims abstract description 15
- 238000006243 chemical reaction Methods 0.000 claims abstract description 42
- 238000003860 storage Methods 0.000 claims abstract description 25
- 238000007599 discharging Methods 0.000 claims abstract description 5
- 238000010791 quenching Methods 0.000 claims abstract description 5
- 230000000171 quenching effect Effects 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 24
- KZMGYPLQYOPHEL-UHFFFAOYSA-N Boron trifluoride etherate Chemical compound FB(F)F.CCOCC KZMGYPLQYOPHEL-UHFFFAOYSA-N 0.000 claims description 19
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 claims description 16
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 12
- AWMVMTVKBNGEAK-UHFFFAOYSA-N Styrene oxide Chemical compound C1OC1C1=CC=CC=C1 AWMVMTVKBNGEAK-UHFFFAOYSA-N 0.000 claims description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 9
- QARVLSVVCXYDNA-UHFFFAOYSA-N bromobenzene Chemical compound BrC1=CC=CC=C1 QARVLSVVCXYDNA-UHFFFAOYSA-N 0.000 claims description 9
- 230000014759 maintenance of location Effects 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 5
- 229910052744 lithium Inorganic materials 0.000 claims description 5
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 5
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 4
- 238000003786 synthesis reaction Methods 0.000 claims description 4
- UBJFKNSINUCEAL-UHFFFAOYSA-N lithium;2-methylpropane Chemical compound [Li+].C[C-](C)C UBJFKNSINUCEAL-UHFFFAOYSA-N 0.000 claims description 3
- WGOPGODQLGJZGL-UHFFFAOYSA-N lithium;butane Chemical compound [Li+].CC[CH-]C WGOPGODQLGJZGL-UHFFFAOYSA-N 0.000 claims description 3
- 125000001979 organolithium group Chemical group 0.000 claims description 2
- 230000003321 amplification Effects 0.000 abstract description 4
- 238000003199 nucleic acid amplification method Methods 0.000 abstract description 4
- 239000012043 crude product Substances 0.000 abstract description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000007789 gas Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 238000005086 pumping Methods 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 230000002107 myocardial effect Effects 0.000 description 2
- 238000010534 nucleophilic substitution reaction Methods 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- NHKJPPKXDNZFBJ-UHFFFAOYSA-N phenyllithium Chemical compound [Li]C1=CC=CC=C1 NHKJPPKXDNZFBJ-UHFFFAOYSA-N 0.000 description 2
- 238000007142 ring opening reaction Methods 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 description 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
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- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000005111 flow chemistry technique Methods 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000001286 intracranial vasospasm Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 210000002464 muscle smooth vascular Anatomy 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
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- 239000006228 supernatant Substances 0.000 description 1
- 230000000948 sympatholitic effect Effects 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0006—Controlling or regulating processes
- B01J19/0013—Controlling the temperature of the process
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/02—Lithium compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2204/00—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices
- B01J2204/002—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices the feeding side being of particular interest
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00002—Chemical plants
- B01J2219/00027—Process aspects
- B01J2219/00033—Continuous processes
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Abstract
The invention discloses a method for industrially synthesizing 2, 2-diphenyl ethanol by using continuous flow equipment, which comprises the following steps: s1, introducing a solution into the storage tank through an industrial diaphragm pump set, filling the solution into a pipeline, and discharging the gas in the storage tank; s2, introducing the solution into the reaction device through an industrial diaphragm pump set, and controlling the reaction temperature in the reaction device to perform three-stage reaction; s3, quenching the reaction by water to prepare the 2, 2-diphenyl ethanol. The invention has the innovation point that the continuous flow equipment is used in industry, a large amount of 2, 2-diphenyl ethanol can be synthesized, the risk coefficient of reaction amplification is reduced, the method has important significance for green environment protection, and a crude product with high purity (GC purity is 80% -90%) is obtained, so that the method has important significance.
Description
Technical Field
The invention relates to the technical field of 2, 2-diphenyl ethanol synthesis, in particular to a method for industrially synthesizing 2, 2-diphenyl ethanol by using continuous flow equipment.
Background
2, 2-diphenylethanol is an important intermediate for synthesizing a plurality of bioactive molecules, medicines, other materials and the like. For example, 2-diphenylethanol is a key intermediate in the synthesis of both panoramine and bisbenoxamide, and the calcium antagonists of the panoramine class have the effect of inhibiting phosphodiesterase and sympatholytic activity in addition to blocking ca2+ influx. Reducing myocardial contractility and relaxing vascular smooth muscle, increasing coronary flow, and reducing myocardial oxygen consumption. Has important effects on treating cardiovascular and cerebrovascular diseases such as hypertension, angina pectoris, arrhythmia, cerebral vasospasm, myocardial ischemia and the like clinically. The bisbenoxamide is mainly absorbed by root systems, so that cell division of meristems of weeds is inhibited, formation of buds and secondary roots is prevented, and the weeds are killed. In addition, it is an important intermediate of some small molecule inhibitors. Therefore, the industrial synthesis of 2, 2-diphenyl ethanol is of great significance.
At present, 2-diphenyl ethanol is synthesized by a main boric acid oxidation method, a metal catalysis and an interposed carbonyl reduction method, and the synthesis method needs to use a catalyst, gas or peroxide and the like, and has great harm, complex operation or post-treatment, high risk coefficient and certain damage to the environment.
In order to solve the above problems, we propose a method for industrially synthesizing 2, 2-diphenylethanol using continuous flow equipment with higher practicability.
Disclosure of Invention
The invention aims to provide a method for industrially synthesizing 2, 2-diphenyl ethanol by using continuous flow equipment, which solves the existing problems.
In order to achieve the above purpose, the present invention provides the following technical solutions: the continuous flow equipment comprises a storage tank, a mass flowmeter, a damper and a back pressure valve which are arranged on the storage tank, and an industrial diaphragm pump set which is communicated with the storage tank;
the industrial diaphragm pump set is communicated with the reaction device;
the industrial diaphragm pump set comprises an industrial diaphragm pump A, an industrial diaphragm pump B, an industrial diaphragm pump C and an industrial diaphragm pump D.
Preferably, the height of the storage tank is 1.5 meters higher than that of the industrial diaphragm pump.
A method for industrially synthesizing 2, 2-diphenylethanol using continuous flow equipment, comprising the steps of:
s1, introducing a solution into the storage tank through an industrial diaphragm pump set, filling the solution into a pipeline, and discharging the gas in the storage tank;
s2, introducing the solution into the reaction device through an industrial diaphragm pump set, and controlling the reaction temperature in the reaction device to perform three-stage reaction;
s3, quenching the reaction by water to prepare the 2, 2-diphenyl ethanol.
Preferably, the solution comprises a styrene oxide solution, a boron trifluoride diethyl ether solution and an organolithium reagent;
wherein the solvent used in the styrene oxide solution is at least one of toluene, tetrahydrofuran and anhydrous diethyl ether;
the solvent used in the boron trifluoride etherate solution must be toluene;
the organic lithium reagent is one of butyl lithium, sec-butyl lithium and tert-butyl lithium.
Preferably, in the step S1, the method further includes the following steps:
the bromobenzene solution and butyllithium were pumped simultaneously using an industrial diaphragm pump A, then after 5min the styrene oxide solution was pumped in by diaphragm pump C and after 10min the boron trifluoride etherate solution was pumped in by industrial diaphragm pump D.
Preferably, the flow rate of the industrial diaphragm pump A is 250g/min-330g/min, the flow rate of the industrial diaphragm pump B is 100g/min-200g/min, the flow rate of the industrial diaphragm pump C is 220g/min-280g/min, and the flow rate of the industrial diaphragm pump D is 260g/min-320g/min.
Preferably, in the step S2, the reaction device controls the reaction temperature in three stages, wherein the temperature of the first stage is-70 ℃ to 75 ℃, the temperature of the second stage is-60 ℃ to 75 ℃, and the temperature of the third stage is-72 ℃ to 78 ℃.
Preferably, in the step S2, the retention time of the first stage is 5min-10min, the retention time of the second stage is 4min-8min, and the retention time of the third stage is 6min-9min.
Compared with the prior art, the invention has the following beneficial effects:
the invention aims to overcome the defects of the prior art, including the dosage of the catalyst, the dangerousness of peroxide, complex operation and the like; has important significance for developing new technological methods.
The continuous flow technology is a hot topic in the chemical industry, is also a current and subsequent development direction, and reflects the value of green chemistry. Because continuous flow technology has the following advantages
1) The continuous flow reaction has better heat and mass transfer effect;
2) The continuous flow chemistry has the advantages of high reaction speed and short time;
3) The continuous flow reaction has no amplification effect, so that the loss caused by the amplification effect is avoided;
4) The continuous flow reaction has the characteristics of simple operation, low risk coefficient and the like.
The invention has the innovation point that the continuous flow equipment is used in industry, a large amount of 2, 2-diphenyl ethanol can be synthesized, the risk coefficient of reaction amplification is reduced, the method has important significance for green environment protection, and a crude product with high purity (GC purity is 80% -90%) is obtained, so that the method has important significance.
Drawings
FIG. 1 is a schematic diagram of the synthetic scheme of the present invention;
fig. 2 is a schematic view of the apparatus structure of the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments.
According to the invention, continuous production is realized by means of continuous feeding and discharging by means of an industrial diaphragm pump by means of nitrogen balance system pressure, a phenyl lithium intermediate is obtained through lithium halogen exchange of butyl lithium and phenyl bromine in a sequential feeding mode, nucleophilic substitution is further carried out on the phenyl lithium intermediate and epoxy, ring opening is carried out under the action of boron trifluoride diethyl ether, and finally the reaction is quenched by water and then subjected to simple post-treatment, so that a target product is obtained.
The synthetic route of the reaction process is as follows:
embodiment case 1:
as shown in fig. 1 and 2, the method for industrially synthesizing 2, 2-diphenylethanol by using continuous flow equipment comprises a storage tank, a mass flowmeter, a damper and a back pressure valve which are arranged on the storage tank, and an industrial diaphragm pump set which is communicated with the storage tank, wherein the height of the storage tank is 1.5 meters higher than that of the industrial diaphragm pump;
the industrial diaphragm pump set is communicated with the reaction device;
the industrial diaphragm pump set comprises an industrial diaphragm pump A, an industrial diaphragm pump B, an industrial diaphragm pump C and an industrial diaphragm pump D.
A method for industrially synthesizing 2, 2-diphenylethanol using continuous flow equipment, comprising the steps of:
s1, introducing a solution into the storage tank through an industrial diaphragm pump set, filling the solution into a pipeline, and discharging the gas in the storage tank;
wherein the solution comprises a styrene oxide solution, a boron trifluoride diethyl ether solution and an organic lithium reagent;
wherein the solvent used in the styrene oxide solution is at least one of toluene, tetrahydrofuran and anhydrous diethyl ether;
the solvent used in the boron trifluoride etherate solution must be toluene;
the organic lithium reagent is one of butyl lithium, sec-butyl lithium and tert-butyl lithium;
simultaneously pumping bromobenzene solution and butyl lithium by using an industrial diaphragm pump A, pumping styrene oxide solution by using a diaphragm pump C after 5min, and pumping boron trifluoride diethyl ether solution by using an industrial diaphragm pump D after 10 min;
the flow rate of the industrial diaphragm pump A is 250g/min-330g/min, the flow rate of the industrial diaphragm pump B is 100g/min-200g/min, the flow rate of the industrial diaphragm pump C is 220g/min-280g/min, and the flow rate of the industrial diaphragm pump D is 260g/min-320g/min;
s2, introducing the solution into the reaction device through an industrial diaphragm pump set, and controlling the reaction temperature in the reaction device to perform three-stage reaction;
wherein the reaction device controls the reaction temperature in three sections, wherein the temperature of the first section is-70-75 ℃, the temperature of the second section is-60-75 ℃, and the temperature of the third section is-72-78 ℃;
the retention time of the first section is 5-10 min, the retention time of the second section is 4-8 min, and the retention time of the third section is 6-9 min;
s3, quenching the reaction by water to prepare the 2, 2-diphenyl ethanol.
Specific embodiment case 2:
as shown in fig. 1, each storage tank is well protected by nitrogen, then tetrahydrofuran solution of bromobenzene is pumped into the storage tank by a diaphragm plunger pump, butyl lithium is pumped into the storage tank by nitrogen, tetrahydrofuran solution of styrene oxide is pumped into the storage tank by a diaphragm plunger pump, toluene solution of boron trifluoride diethyl ether is pumped into the storage tank by a diaphragm plunger pump, the first reaction temperature is controlled to be about-70 ℃, the second reaction temperature is controlled to be about-63 ℃, and the third reaction temperature is controlled to be about-75 ℃; performing operations such as exhausting in advance, filling a pipeline with liquid, then starting a pump 1 and a pump 2 simultaneously, performing lithium-halogen exchange in a reaction tube for 7min, and performing nucleophilic substitution on the obtained intermediate 2 and a THF solution of styrene oxide in the reaction tube for 5.5min; finally, ring opening is carried out on the intermediate 3 obtained in the second step and toluene solution of boron trifluoride diethyl etherate in a reaction tube, and the action time is 7min; then the reactants are introduced into (1/2 of the ice-water mixture is stored) for quenching, and then the supernatant is taken and analyzed by GC to obtain the crude product with the purity of 86.1 percent;
1 HNMR(400MHz，CDCl 3 ):δ＝7.37–7.35(m，4H)，7.31–7.29(m，4H)，7.28–7.26(m，2H)，4.26–4.24(m，1H)，4.20(t，J＝6.6Hz，2H)，1.58(t，J＝6.2Hz，1H)。
although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. The continuous flow equipment is characterized by comprising a storage tank, a mass flowmeter, a damper and a back pressure valve which are arranged on the storage tank, and an industrial diaphragm pump set which is communicated with the storage tank;
the industrial diaphragm pump set is communicated with the reaction device;
the industrial diaphragm pump set comprises an industrial diaphragm pump A, an industrial diaphragm pump B, an industrial diaphragm pump C and an industrial diaphragm pump D.
2. The continuous flow apparatus of claim 1, wherein the height of the storage tank is 1.5 meters above an industrial diaphragm pump.
3. A process for the industrial synthesis of 2, 2-diphenylethanol using continuous flow equipment, characterized in that it comprises the following steps:
s1, introducing a solution into the storage tank through an industrial diaphragm pump set, filling the solution into a pipeline, and discharging the gas in the storage tank;
s2, introducing the solution into the reaction device through an industrial diaphragm pump set, and controlling the reaction temperature in the reaction device to perform three-stage reaction;
s3, quenching the reaction by water to prepare the 2, 2-diphenyl ethanol.
4. The method for industrially synthesizing 2, 2-diphenylethanol using continuous flow equipment according to claim 3, characterized in that said solutions comprise a styrene oxide solution, a boron trifluoride etherate solution and an organolithium reagent;
wherein the solvent used in the styrene oxide solution is at least one of toluene, tetrahydrofuran and anhydrous diethyl ether;
the solvent used in the boron trifluoride etherate solution must be toluene;
the organic lithium reagent is one of butyl lithium, sec-butyl lithium and tert-butyl lithium.
5. The method for industrially synthesizing 2, 2-diphenylethanol using the continuous flow apparatus according to claim 3, characterized by further comprising the steps of:
the bromobenzene solution and butyllithium were pumped simultaneously using an industrial diaphragm pump A, then after 5min the styrene oxide solution was pumped in by diaphragm pump C and after 10min the boron trifluoride etherate solution was pumped in by industrial diaphragm pump D.
6. The method for industrially synthesizing 2, 2-diphenylethanol using a continuous flow apparatus according to claim 5, wherein the flow rate of the industrial diaphragm pump A is 250g/min to 330g/min, the flow rate of the industrial diaphragm pump B is 100g/min to 200g/min, the flow rate of the industrial diaphragm pump C is 220g/min to 280g/min, and the flow rate of the industrial diaphragm pump D is 260g/min to 320g/min.
7. The method for industrially synthesizing 2, 2-diphenylethanol using the continuous flow apparatus according to claim 3, characterized in that in said step S2, the reaction apparatus controls the reaction temperature in three stages, wherein the temperature in the first stage is-70℃to 75 ℃, the temperature in the second stage is-60℃to 75 ℃, and the temperature in the third stage is-72℃to 78 ℃.
8. The method for industrially synthesizing 2, 2-diphenylethanol using the continuous flow apparatus according to claim 3, wherein in said step S2, the retention time of the first stage is 5min to 10min, the retention time of the second stage is 4min to 8min, and the retention time of the third stage is 6min to 9min.
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