CN116173166A - Qi-tonifying, defending and asthma-preventing granule and production system and production process thereof - Google Patents

Qi-tonifying, defending and asthma-preventing granule and production system and production process thereof Download PDF

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CN116173166A
CN116173166A CN202211310916.8A CN202211310916A CN116173166A CN 116173166 A CN116173166 A CN 116173166A CN 202211310916 A CN202211310916 A CN 202211310916A CN 116173166 A CN116173166 A CN 116173166A
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medicine
channel
roller
blank
tonifying
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CN116173166B (en
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薛汉荣
余建玮
喻强强
余涛
孙朋
叶超
沈建丽
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Jiangxi University of Traditional Chinese Medicine
Affiliated Hospital of Jiangxi University of TCM
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Jiangxi University of Traditional Chinese Medicine
Affiliated Hospital of Jiangxi University of TCM
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/60—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a horizontal or inclined axis
    • B01F27/72—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a horizontal or inclined axis with helices or sections of helices
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract

The invention relates to a qi-tonifying, health-protecting and asthma-preventing granule, a production system and a production process of the granule, wherein the qi-tonifying, health-protecting and asthma-preventing granule is prepared from the following raw materials: astragalus root, bighead atractylodes rhizome, divaricate saposhnikovia root, cassia twig, white paeony root, ginger, chinese date, liquorice, curculigo rhizome and epimedium herb; the production system comprises a mixing channel, a cake pressing component and a blank making component, wherein a redundant area is obliquely arranged at the far end of the mixing channel upwards, the blank making channel is downwards arranged, the cake pressing component comprises cake pressing rollers which are sleeved in the blank making channel in a bilateral symmetry manner, the blank making component comprises a main die roller which is arranged below the cake pressing rollers in a staggered manner, an upper guide plate is arranged between the cake pressing rollers and the main die roller, the output end of the blank making channel is in butt joint with an external screening piece, after the medicine blank particles thrown out by the blank making channel are screened, the screened qualified medicine blank particles enter a pellet making disc, the medicine blank particles inside are enabled to be rolled into pellets, and finally the medicine pellets conforming to the particle size are screened out through sieve holes at the bottom in the pellet making disc, so that finished granules are obtained.

Description

Qi-tonifying, defending and asthma-preventing granule and production system and production process thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicine granule production, in particular to a qi-tonifying and health-protecting asthma-preventing granule, and simultaneously discloses a production system and a production process of the granule.
Background
The traditional Chinese medicine considers that healthy qi is normal functional activity of human body, adaptability to external environment, disease resistance and rehabilitation capability, has the function of maintaining physiological balance and stability, and is healthy qi of human body with defending function, and comprises functional activities of nutrient, defensive, qi, blood, essence, spirit, body fluid, liquid, viscera, meridian and the like. When the patient is deficient in vital energy, six pathogenic factors invade, and the body is prone to suffering from diseases; healthy qi is strong and is resistant to pathogenic qi, so it is not easy to get ill. Therefore, deficiency of healthy qi is an intrinsic factor of the pathogenesis, and invasion of exogenous pathogenic factors is an extrinsic condition of the pathogenesis. The defensive function of the human body is directly related to the strength of qi and yang. Defensive qi is the first line of defense of the body against exogenous pathogens. The lung governs qi, breathes in the mouth, governs fur, opens into the nose, and warms evil, so that the whole respiratory system of the human body is led to the outside, is easily affected by climate, and is easily contacted with humanized allergen in the environment. Among them, the main cause of morbidity is common cold and climate change. By investigation of the causes of acute attacks in 100 cases of asthmatics, it was found that the causes of exogenous wind-cold account for 74% [1]. Weak qi and yang, deficiency of defensive qi, and reduced respiratory tract defensive function and immunoregulation, which are susceptible to invasion of pathogenic factors, cause depression of lung qi, disorder of dispersing and descending, aggravate airway inflammation, increase airway responsiveness, and cause asthma attack. The internal cause of repeated attack of asthma is 'qi-yang deficiency and defensive qi deficiency', and 'Wei Qigen is derived from lower jiao, nourishes middle jiao and develops on upper jiao', which integrates lung, spleen and kidney tonifying, and is superior to the thought of single lung tonifying, spleen strengthening and kidney tonifying in traditional asthma remission stage treatment.
Therefore, by invigorating qi and warming yang for defending, the respiratory tract defending function and the immunity regulating capability are enhanced, the airway inflammation is reduced, the airway responsiveness is reduced, and the recurrent attacks of asthma can be reduced or controlled. According to the scheme, wei Qigen is derived from lower energizer, nourishes middle energizer, is developed in upper energizer and has hidden kidney deficiency no matter whether or not the patients with asthma clinically have kidney deficiency, the granule for tonifying qi, protecting health and preventing asthma is disclosed.
Meanwhile, in order to facilitate taking, the formulation of the prescription is defined as granules. The traditional Chinese medicine granule is prepared from traditional Chinese medicine decoction pieces serving as raw materials through the production processes of decoction extraction, deslagging separation, concentration, mixing and stirring, granulation, packaging and the like, and the traditional Chinese medicine granule is a novel formula medicine with unified specification, unified dosage and unified quality standard, and the medicine granulation method can be divided into three main categories: the method has the advantages that the surface of the particles prepared by the wet method is wet, the particles are good in quality, attractive in appearance, strong in wear resistance, good in compression forming property and the like, however, most of the traditional equipment adopts the wet method for granulating, the medicine powder is unevenly stirred, meanwhile, the medicine mixture can be accumulated and blocked in the conveying process, the sufficient blanking amount can not be ensured, the quality of the granules can not be ensured, and certain defects exist in granulating, such as low granulating precision, uneven particle size and uneven particle finished product.
A third object of the present invention is to disclose a process for the production of the above granules.
Disclosure of Invention
Aiming at the defects and problems, the invention provides the qi-tonifying and defending asthma-preventing granule, and simultaneously discloses a production system and a production process of the granule.
The device is unique in structure and ingenious in design, the drug powder, water and additives can be uniformly mixed through the mixing channel arranged on the double-auger, the quality of traditional Chinese medicine granules is guaranteed, the auger can be conveyed to the redundant area in the conveying process, the drug mixture can slide down into the blank making granule channel, the uniformity of the feeding amount in the blank making granule channel is guaranteed in an auxiliary mode, the drug mixture can be rolled into a cake shape through the cake pressing component and conveyed to the blank making granule component, the drug cake is rolled into the die sleeve ring by utilizing the mutual matching of the main die roller and the auxiliary roller, the traditional Chinese medicine granules with the same granule size are cut into the traditional Chinese medicine granules in the die sleeve ring, the drying piece can be semi-dried, the ejection of the traditional Chinese medicine granules in the die sleeve ring is realized by the outer ejection roller, the granulating precision is improved, and the quality of the granule finished product is guaranteed.
The qi-tonifying and health-protecting asthma-preventing granule is prepared from the following raw materials in parts by weight: 20-35 parts of astragalus membranaceus, 6-15 parts of bighead atractylodes rhizome, 6-15 parts of divaricate saposhnikovia root, 6-15 parts of cassia twig, 6-15 parts of white paeony root, 6-15 parts of ginger, 6-15 parts of Chinese date, 7-12 parts of liquorice, 6-15 parts of rhizoma curculiginis and 6-15 parts of herba epimedii.
In the medicinal materials, the weight ratio of the bighead atractylodes rhizome to the divaricate saposhnikovia root to the cassia twig is 1:1:1.
The utility model provides a production system of benefit gas guard anti-wheeze granule, includes the compounding passageway, the feed inlet has been seted up on the compounding passageway to be equipped with water delivery shower nozzle and additive shower nozzle, and be equipped with a pair of auger in the compounding passageway, still include cake subassembly and system base granule subassembly, the distal end tilt up of compounding passageway has redundant district, and be equipped with system base granule passageway downwards at the compounding passageway distal end, cake subassembly includes the cake roller of bilateral symmetry suit in system base granule passageway, system base granule subassembly includes the dislocation main mould roller of establishing in cake roller below, is equipped with the guide plate between cake roller and the main mould roller, main mould roller main part includes the support sleeve, and the periphery side cladding of support sleeve is equipped with the mould lantern ring, and is equipped with the breach section on the support sleeve, and is equipped with the inner tube in the axial in the support sleeve, hub connection between inner tube and the support sleeve, be equipped with the heating member in the inner tube, the center dead axle of inner tube is fixed in the system base granule passageway, and the mould lantern ring is equipped with the ring for rotating the cover in the support sleeve, and the both ends extension of mould lantern ring is equipped with the ring, is equipped with the tooth segment department in the top tooth segment of support sleeve is equipped with the tooth top tooth profile pin outside the tooth roller, and the tooth profile pin sets outside the tooth die sleeve is equipped with a plurality of tooth sets outside the tooth profile pin roll meshed with in the tooth segment in the inside the drive ring and the tooth segment of the drive sleeve in the rotation.
An auxiliary roller for assisting in rolling the mould lantern ring is arranged on the side edge of the main mould roller, and the output end of the blank making grain channel is in butt joint with an external screening piece; the blank making grain channel is transversely provided with a flat hole corresponding to the roll shaft of any one cake pressing roll, the roll shaft of the cake pressing roll is matched and arranged in the flat hole, the cake pressing roll can slide in the flat hole through the roll shaft, the cake pressing gap is adjusted, and the flat hole is provided with a locking block for fixing the roll shaft; the mould lantern ring comprises a plurality of uniformly distributed inner grooves, and the mould lantern ring is integrally and rotatably sleeved on the supporting sleeve.
The heating piece is a heating wire, a plurality of heating holes are formed in the inner barrel, the heating wire is correspondingly placed in the heating holes, and the heating wire conducts heat to the copper supporting sleeve through the hub, so that the medicine blank particles in the die sleeve ring are semi-dried.
The notch section is positioned at the left lower side of the support sleeve, a lower guide plate is arranged at the outer side of the notch section of the support sleeve, the lower guide plate is of an arc-shaped structure, and the lower guide plate corresponds to the notch section of the support sleeve.
An end plate is arranged between the main gear and the supporting sleeve, the end plate is fixed on the central fixed shaft, an annular hole corresponding to the toothed ring is formed in the end plate, the toothed ring penetrates through the annular hole to be meshed with the main gear, the whole end plate is larger than the main die roller, and the main gear drives the toothed ring to enable the die lantern ring to rotate on the circular supporting plate.
A production method of qi-tonifying and health-protecting asthma-preventing particles, which comprises the following steps:
step S1, starting a production system by workers, putting concentrated and purified medicinal material powder into a feed inlet, enabling the medicinal material powder to enter a mixing channel through the feed inlet, respectively outputting water and a coagulant into the mixing channel by a water delivery nozzle and an additive nozzle at the side edge of the feed inlet, mixing the medicinal material powder with the medicinal material powder in the mixing channel, uniformly stirring the medicinal material powder by a double auger arranged in the mixing channel, and conveying the medicinal material powder to a blank making channel in a spiral manner;
s2, under the operation of a cake pressing assembly and a blank making assembly, the medicine mixture entering the blank making channel is firstly rolled and cut into uniform medicine cakes, then is further cut into medicine blanks with the same particle size, and the medicine blanks are demoulded and thrown out after being heated and dried;
step S3, screening the screened qualified drug blanks, enabling the screened qualified drug blanks to enter a pellet making disc, controlling three motors to start at the moment, enabling the arc-shaped fixed arms to drive the hinged arms by the motors with different rotating speeds and directions, enabling the pellet making disc to continuously shake circumferentially around the shaft seat under the mutual cooperation of the hinged arms, enabling the internal drug blanks to be rolled into pellets, screening out the drug pellets conforming to the particle size through sieve holes at the bottom in the pellet making disc, and repeating the steps S1 to S3 to continuously produce the drug pellets.
A production method of a traditional Chinese medicine granule production system comprises the following steps of: taking 140 jin of medicinal materials according to the weight ratio, adding enough water for decoction for 2 times, wherein the first time is 110 minutes and the second time is 80 minutes, merging the medicinal liquid obtained by the two times of decoction, filtering and concentrating until the relative density of the medicinal liquid is 1.1, adding ethanol to enable the alcohol concentration to be 60%, standing for 6-8 hours, filtering and concentrating again until the relative density of the medicinal liquid is 1.14, and finally carrying out spray drying on the concentrated medicinal liquid to obtain corresponding medicinal material powder
The invention has the beneficial effects that:
1. compared with the traditional western medicine hormone treatment with a plurality of adverse reactions, the traditional Chinese medicine preparation qi-tonifying and yang-warming protective particles have no obvious adverse reaction, and years of clinical practice prove that the traditional Chinese medicine preparation qi-tonifying and yang-warming protective particles can strengthen the defending function and the immunoregulation capability of the respiratory tract, reduce airway inflammation, reduce airway reactivity, reduce or control repeated attacks of asthma, and have the advantages of good curative effect and low price;
2. the production system structure of this granule is unique, design benefit, the compounding passageway that utilizes the pair auger to set up can make medicine powder and water and additive stirring compounding even, guarantee the quality of traditional chinese medicine granule, the auger is in carrying the in-process, unnecessary medicine compounding can be carried to the redundant district in, prevent the condition that the backlog leads to blockking up from appearing in the system base grain passageway, medicine compounding in the redundant district also can be continuous enter into the system base grain passageway simultaneously, the auxiliary assurance system base grain passageway in medicine compounding feed amount's homogeneity, avoid the condition that leads to the fact the influence to base grain quality because of the feed amount is not enough, can be in cake form and carry to the system base grain subassembly with the medicine compounding roll-in, utilize the cooperation of main mould roller with assisting the roller, the medicine cake is rolled in the mould cover intra-annular, cut into granule size the same traditional chinese medicine granule, the heating element can semi-dry the medicine base grain in the mould cover intra-annular, and realize the liftout of the mould cover medicine base grain by outer liftout roll, the pelletization precision has been improved, guarantee the quality of traditional chinese medicine granule. Can also be popularized and applied to the production of other similar granules.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a flow chart of granulation for the system for producing granules for tonifying qi and defending asthma according to the present invention.
Fig. 2 is a schematic structural diagram of a production system of qi-tonifying and health-protecting asthma-preventing particles according to the present invention.
Fig. 3 is an exploded view of fig. 2.
Fig. 4 is a cross-sectional view of one of the internal parts of the system for producing particles for the benefit of the present invention.
FIG. 5 is a schematic view of a main mold roll.
FIG. 6 is a second schematic diagram of the main mold roll structure.
Fig. 7 is a second internal cross-sectional view of the system for producing particles for gas-beneficial and anti-wheezing according to the present invention.
FIG. 8 is a schematic view of a specific pellet assembly configuration.
Fig. 9 is a schematic structural view of a special compound mixer.
Fig. 10 is a schematic diagram of the steps of granule production using the qi-tonifying and anti-asthma granule production system of the present invention.
In the figure: 1-mixing channel, 2-feed inlet, 3-water delivery nozzle, 4-additive nozzle, 5-redundant zone, 6-green pellet making channel, 7-auger, 8-motor one, 9-cake roller, 10-upper deflector, 11-lower deflector, 12-main die roller, 121-support sleeve, 122-notched section, 123-die collar, 124-inner barrel, 125-hub, 126-heated bore, 13-outer top roller, 14-auxiliary roller, 18-main gear, 19-toothed ring, 20-end plate, 21-spike tooth, 22-center fixed shaft, 23-inner shaft, 24-shaft bracket, 25-pellet making assembly, 251-pellet making disc, 252-fixed chassis, 253-motor, 254-upper gear, 255-middle gear, lower gear, 257-shaft seat, 258-funnel, 259-discharge pipe, 2510-arc fixed arm, 2511-hinge arm, 5-motor, 2516-gear, 26-fixed plate, 27-hopper, 28-mixing hopper, 28-auxiliary gear, 29-30-drive link, 31-32-swing link, 32-32.
Detailed Description
The invention will be further described with reference to the drawings and examples.
Embodiment 1, this embodiment discloses a qi-tonifying, defending and asthma-preventing granule, which is prepared from the following raw materials in parts by weight: 20-35 parts of astragalus membranaceus, 6-15 parts of bighead atractylodes rhizome, 6-15 parts of divaricate saposhnikovia root, 6-15 parts of cassia twig, 6-15 parts of white paeony root, 6-15 parts of ginger, 6-15 parts of Chinese date, 7-12 parts of liquorice, 6-15 parts of rhizoma curculiginis and 6-15 parts of herba epimedii. Specifically, in this embodiment, 27 parts of astragalus membranaceus, 9 parts of bighead atractylodes rhizome, 9 parts of divaricate saposhnikovia root, 9 parts of cassia twig, 9 parts of white paeony root, 9 parts of ginger, 9 parts of Chinese date, 9 parts of liquorice, 9 parts of curculigo rhizome and 9 parts of epimedium.
Taking 140 jin of medicinal materials, adding enough water for decoction for 2 times, wherein the first time is 110 minutes, the second time is 80 minutes, merging the medicinal liquid obtained by the two times of decoction, filtering and concentrating until the relative density of the medicinal liquid is 1.1, adding ethanol to enable the alcohol concentration to be 60%, standing for 6-8 hours, filtering and concentrating again until the relative density of the medicinal liquid is 1.14, and finally carrying out spray drying on the concentrated medicinal liquid to obtain corresponding medicinal material powder.
The preparation is formulated as a prescription for invigorating qi, warming yang and protecting health, and comprises Gu Fangyu screen powder, ramulus Cinnamomi decoction and two kinds of herba Epimedii.
The prescription improves the respiratory tract defense function by tonifying lung and strengthening defensive qi; regulating ying and wei to raise immunity regulating capacity so as to raise the adaptability of respiratory tract to stimulating factors in environment; by stimulating the true elements, kidney qi is vigorous and defensive qi is filled. The whole formula achieves the aim of preventing recurrent attacks of asthma by invigorating qi and warming yang.
The principal drug in the prescription: astragalus root, radix astragali, sweet and slightly warm, enters the lung and spleen meridians, has the actions of tonifying qi and consolidating superficial resistance, and can strengthen the spleen and lung qi in the interior and arrest sweating in the exterior, huang Qi Gan Wenchun yang in Zhu Shu (pearl bag), it uses five ingredients: deficiency is compensated for, and the deficiency is also compensated for; primordial qi is also benefited; strengthening spleen and stomach, thirdly; … … ";
ministerial drugs: xian Mao, pungent and hot, xian Ling Pi, xin Gan, all enter kidney meridian, tonify kidney yang, help Huang Qi strengthen qi and warm yang; the white atractylodes rhizome is sweet and flat, enters lung and spleen and stomach channels, invigorates spleen and supplements qi, and helps astragalus root strengthen the effects of supplementing qi and consolidating exterior; ramulus Cinnamomi, pungent and sweet in flavor, can enter lung meridian, and its application in Ben Jing Shu Zhi (the present meridian dredging syndrome) … … has six: the riding is harmonized; the Chinese medicinal composition is a Chinese character 'Yuan Tong' type; the water is removed; the lower air is generated; the blood stasis is removed; the recipe is in the middle warmer. The action of activating yang can help the principal drugs to tonify without stagnation;
adjuvant drug: radix Saposhnikoviae, pungent and sweet in taste and slightly warm in nature, has effects of dispelling pathogenic wind, relieving exterior syndrome, relieving spasm, etc., and radix astragali has effects of radix Saposhnikoviae, consolidating exterior without retaining pathogenic factors; white peony root, radix Paeoniae alba, bitter in taste and slightly cold in nature, has the effects of nourishing blood and astringing yin, and one can restrict the dryness-heat property of astragalus root, curculigo rhizome and epimedium; the two are combined with Guizhi to regulate nutrient and defensive qi. Ginger, rhizoma Zingiberis recens, with pungent and warm nature and jujube, and sweet and flat nature, can promote qi flow of the spleen and stomach and promote hair growth to harmonize nutrient.
The preparation method comprises the following steps: the honey-fried licorice root is prepared from two steps: firstly, the Chinese herbal medicine is an adjuvant medicine for invigorating spleen and replenishing qi; firstly, the medicines are blended. So the recipe has strict compatibility and has the effects of tonifying qi, warming yang and protecting health.
In the whole recipe, yupingfeng powder is prepared from astragalus root, white atractylodes rhizome and ledebouriella root, and has the functions of invigorating Qi, strengthening body resistance, arresting sweating, dispelling wind and resisting wind. Because the recipe has the efficacy of preventing wind like a human body and is precious like jade, the name of the recipe is "Yupingfeng" which is a classical prescription for strengthening body resistance and consolidating exterior in traditional Chinese medicine. Clinical experiments show that the modified jade screen powder can obviously improve asthma symptoms, obviously reduce the repeated times of asthma attacks and improve the life quality of children suffering from asthma [4], and the modified jade screen powder is superior to a control group in improvement of FEV1% and PEFR of lung function, so that the modified jade screen powder has a certain effect on improving the lung function during asthma attacks [5]. Therefore, the whole formula achieves the aim of preventing bronchial asthma attacks by invigorating qi and warming yang.
For ease of administration, the dosage form to be formulated is positioned as a granule. When the existing equipment adopts wet granulation to produce traditional Chinese medicine granules, the conditions that the stirring of medicine powder is uneven and the quality of the granules cannot be ensured exist in most cases, and the conditions that the granulating precision is low, the granule size is uneven and the granule finished product is uneven exist in granulating, so that certain defects exist.
When the above prescription is produced by adopting a wet granulation process, the problems also exist, therefore, the embodiment provides a production system of the air-supplementing defending and anti-wheezing particles, as shown in fig. 1-4, the production system comprises a rectangular mixing channel 1, a feed inlet 2 is arranged above the front end of the mixing channel 1, various medicinal material powder after concentration and purification can enter the mixing channel 1 through the feed inlet 2, a water delivery nozzle 3 and an additive nozzle 4 are respectively arranged on the side edge of the feed inlet 2, the water delivery nozzle 3 is connected with an external water source through a pipeline, the additive nozzle 4 is connected with an external additive barrel through a pipeline, the output ends of the water delivery nozzle 3 and the additive nozzle 4 are communicated with the mixing channel 1 through pipelines, at least two pairs of augers 7 are arranged in the mixing channel 1, the augers 7 are staggered and sleeved in the mixing channel 1 in parallel, namely the axes of the augers are mutually parallel, the threads outside each augers are correspondingly staggered, the tail ends of the augers 7 extend out of the mixing channel 1 in a shaft frame 24, the gearbox 7 are respectively arranged at the side edges of the feed inlet 2, the gearbox, the head ends of the augers 7 are respectively, and the gearbox are respectively connected with the additive nozzle 4 through a pipeline, the two pairs of augers are evenly connected with the drug powder, the drug powder are evenly mixed, and the drug powder is delivered into the mixing channel through the mixing channel, and the drug powder is evenly mixed by the output through the spiral delivery end and the spiral delivery agent, and the drug powder is evenly mixed by the drug delivery agent, and the drug delivery;
the far end of the mixing channel 1 is upwards inclined with a redundant area 5, and a blank making channel 6 is downwards arranged at the far end of the mixing channel 1, part of medicine mixing can be conveyed into the redundant area in the conveying process of the auger, so that the condition that the blank making channel 6 is blocked due to backlog is prevented, meanwhile, the medicine mixing in the redundant area 5 can continuously enter the blank making channel 6, the uniformity of the feeding amount of the medicine mixing in the blank making channel 6 is ensured, the medicine mixing uniformity is rolled into medicine cakes, the condition that the quality of the blank is influenced due to insufficient or excessive feeding amount is avoided, the cake pressing component comprises cake pressing rollers 9 which are symmetrically arranged in the blank making channel 6 in a left-right mode, the cake pressing rollers 9 are sleeved in the blank making channel 6 in a rotating mode through roller shafts, and the second motor arranged outside the blank making channel can drive the cake pressing rollers 9 to rotate so as to roll the medicine mixing into cakes;
the main mould roller 12 is arranged below the cake pressing roller 9 in a staggered way, an upper guide plate 10 is arranged between the cake pressing roller 9 and the main mould roller 12, the upper guide plate 10 is of an arc-shaped structure, the far end of the upper guide plate 10 is positioned above the main mould roller 12, and medicine cakes can be guided onto the main mould roller 12 by the upper guide plate 10.
As shown in fig. 5-6, two configurations of the main mold roll 12 are shown. The main part of main mould roller 12 includes columniform support sleeve 121, support sleeve 121 adopts the copper material, the periphery side cladding of support sleeve 121 is equipped with the mould lantern ring 123, the mould lantern ring 123 comprises a plurality of indent that the equipartition was arranged for evenly cut the medicine cake, cut the medicine cake into the identical base grain of granule, be equipped with breach section 122 in support sleeve 121's left downside, and be equipped with inner tube 124 at support sleeve 121 central coaxial, through many wheel hub 125 fixed connection between inner tube 124 and the support sleeve 121, wheel hub 125 can adopt the platy. A heating hole 126 is formed in the inner barrel 124, a heating piece is arranged in the heating hole 126, a heating wire or a heating rod can be adopted for the heating piece, heat is transmitted to the supporting sleeve 121 through the hub 125, heat conduction is carried out on the supporting sleeve 121, further, a certain degree of semi-drying can be carried out on the blank grains in the supporting sleeve 121 in the rotating process of the die lantern ring, moisture in the dried blank grains is fixed in the blank grain making channel 6 through a central fixed shaft, the die lantern ring 123 is rotationally sleeved on the supporting sleeve 121, toothed rings 19 are fixedly extended at two ends of the die lantern ring 123, an outer top roller 13 is arranged at a notch section 122 of the supporting sleeve 121, a plurality of spike teeth 21 are uniformly distributed on the periphery side of the outer top roller 13, the spike teeth 21 are matched and meshed in the die lantern ring 123, the inner shaft 23 of the outer top roller 13 is rotationally sleeved in the blank grain making channel 6 through the spike teeth 21, and the main gears 18 at two ends of the inner shaft 23 are meshed with the toothed rings 19, the output end of a motor II is connected with the inner shaft 23, when the outer top roller rotates, the outer top roller and the medicine can be driven to rotate relatively to the die 13, and the medicine is delivered to the position of the die sleeve when the medicine is rotationally ejected from the die sleeve 121, and the medicine is delivered to the inside the die sleeve, and the medicine is cut;
an end plate 20 is arranged between the main gear and the supporting sleeve 121, the end plate 20 is fixed on the central fixed shaft, an annular hole corresponding to the toothed ring 19 is formed in the end plate 20, the toothed ring 19 penetrates through the annular hole to be meshed with the main gear 18, the whole end plate 20 is larger than the main die roller 12, and the end plate is arranged for blocking materials so as to prevent medicine cakes from falling into the main gear 18 or the toothed ring 19 to cause influence; an auxiliary roller 14 for assisting in rolling a die sleeve ring 123 is arranged above the right side of the main die roller 12, two ends of the auxiliary roller 14 are rotationally sleeved in a blank making channel 6, the outer peripheral side of the auxiliary roller 14 is attached to the die sleeve ring 123, when the rolled medicine cake is conveyed to the main die roller 123, the medicine cake is rolled into the die sleeve ring 123 by the auxiliary roller 14 and cut into medicine blanks with the same particle size, a lower guide plate 11 is arranged outside a notch section 122 of a supporting sleeve 121, the lower guide plate 11 is of an arc-shaped structure, the lower guide plate 11 corresponds to the notch section of the supporting sleeve 121, the lower guide plate 11 can guide and discharge the medicine blanks subjected to blanking, the output end of the blank making channel 6 is connected with a sealing channel, the output end of the sealing channel is in butt joint with a screening piece, the screening piece adopts the existing screening equipment, the particle size of the medicine blanks is not screened in detail, the qualified medicine blanks are discharged to the next procedure, unqualified medicine blanks are conveyed to a material mixing channel 1, and qualified medicine blanks are quantitatively conveyed, and unqualified medicine blanks can be conveyed by adopting spiral conveying or negative pressure conveying;
after the medicinal material powder enters the mixing channel 1, water and a coagulant are respectively output by the water delivery nozzle 3 and the additive nozzle 4, the medicinal material powder is mixed to form a medicinal material mixture, the medicinal material mixture is uniformly stirred and mixed by the double augers 7, the medicinal material powder is uniformly stirred, the augers can be conveyed into the redundant area 5 in the conveying process, the situation that the blocking is caused by backlog of the blank making channel 1 is prevented, meanwhile, the medicinal material in the redundant area 5 can continuously enter the blank making channel 1, the uniformity of the feeding amount of the medicinal material in the blank making channel 1 is ensured, the motor two drives the cake pressing roller 9 to rotate, the medicinal material mixture is uniformly rolled into medicinal cakes, the medicinal material cakes are cut into medicinal blank grains with the same grain size by the auxiliary roller 14 in the die sleeve ring 123 when being guided by the upper guide plate 10, meanwhile, the heating wire can transfer heat to the supporting sleeve 121 through the hub 125, the inside the blank making channel 1 can be subjected to the condition that the blank grains are blocked in the die sleeve ring, the moisture in the blank is continuously discharged outside the die ring 123, the dried blank grains are discharged outside the die ring 13 when the die ring is driven to the inside, the blank grains are dried, the blank grains are discharged outside the die ring 13, and the blank grains are dried, the blank grains are discharged outside the die grains and the blank grains are dried, and the blank grains are discharged to the qualified and the quality is discharged, and the quality is discharged to the quality.
According to the production system of the embodiment, the mixing channel 1 arranged by the double augers can uniformly mix medicine powder, water and additives, the quality of traditional Chinese medicine granules is guaranteed, the augers 7 can be conveyed into the redundant area 5 in the conveying process, the situation that blockage is caused by backlog of the blank making channel 6 is prevented, meanwhile, the medicine mixing in the redundant area 5 can continuously enter the blank making channel 6, the uniformity of the medicine mixing feeding amount in the blank making channel 6 is ensured in an auxiliary manner, the condition that the quality of the blank is influenced due to insufficient feeding amount is avoided, the medicine mixing can be rolled into a cake shape and conveyed onto the blank making component through the cake pressing component, the medicine cake is rolled into the die sleeve 123 by utilizing the mutual matching of the main die roller 12 and the auxiliary roller, the traditional Chinese medicine granules with the same particle size are cut into the traditional Chinese medicine granules, the heating piece can be semi-dried by the medicine blank in the die sleeve 123, the ejection accuracy of the medicine blank in the die sleeve 123 is realized by the outer ejection roller 13, the quality of the finished product is improved, and the quality of the traditional Chinese medicine granules is guaranteed.
Example 2 a system for producing a Chinese medicinal granule in this embodiment will be described centering on the differences from example 1.
In this embodiment, flat holes corresponding to the roll shafts of any one of the cake rollers 9 are transversely formed in the blank making grain channel 6, the roll shafts of the cake rollers 9 are matched and arranged in the flat holes, the cake rollers 9 can slide in the flat holes through the roll shafts, cake pressing gaps are adjusted, locking blocks for fixing the roll shafts are arranged on the flat holes, and the control of the thickness of the rolled medicine cake is realized through adjustment of the cake rollers 9.
Example 3 a system for producing a Chinese medicinal granule in this embodiment will be described centering on the differences from example 1.
In the implementation process of embodiment 1, the drug mixture is made into drug granules, secondary processing of the drug granules may not be realized, the drug granules are processed into drug granules, and the next production process is not satisfied, aiming at the problems, this embodiment provides a special-purpose granule making assembly for cooperating with embodiment 1, as shown in fig. 8, a shaft seat 257 is fixed at the central part of a fixed chassis, a lower shaft of a lower gear 256 is rotatably sleeved in the shaft seat 257, the central shaft of a middle gear 255 is of a hollow structure, the middle gear 255 is rotatably sleeved on the lower shaft of the lower gear 256 through the central shaft, the upper shaft of the upper gear 254 is of a hollow structure, the upper gear 254 is rotatably sleeved on the central shaft of the middle gear 255 through the upper shaft, after the upper gear 254, the middle gear 255 and the lower gear 256 are completely sleeved, the central shaft of the middle gear 255 is higher than the upper shaft, the lower shaft of the lower gear 256 is higher than the central shaft, arc-shaped fixed arms 2510 are respectively and are respectively fixed outwards, a hinge arm 1 is hinged at the free end of each arc-shaped fixed arm 2510, the free end of each arc-shaped fixed arm 2511 is hinged with a funnel 251, the free end of the hinge arm 2511 is provided with a plurality of holes, the free end of the corresponding funnel-shaped motor 251 is provided with a plurality of holes, the upper gear wheels 251 are meshed with the upper gear holes and a motor 253, the funnel-shaped carrier wheel 251 are arranged at the bottom end of the funnel-shaped carrier is arranged, and the funnel-shaped carrier is provided with the upper gear 255, and the upper gear carrier is corresponding to the upper gear carrier has a motor carrier wheel and the upper carrier has a carrier gear and a carrier gear and a carrier is corresponding to the carrier axle and a carrier axle;
the medicine blank grain enters into the pelleting disc 251, the controller controls the three motors to start, when the rotating speeds of the motors are different and the rotating directions are different, the upper gear 254, the middle gear 255 and the lower gear 256 are different in rotating speed and different in rotating directions, and then the arc-shaped fixed arms 2510 can be driven to drive the articulated arms 2511 respectively, the pelleting disc 251 can continuously shake around the shaft seat 257 along the circumference through the mutual matching among the articulated arms 2511, the medicine blank grain inside is rolled into granules, and the medicine granules conforming to the grain size are screened out through the sieve holes at the bottom in the pelleting disc 251, so that the medicine granules are manufactured.
Example 4 a system for producing a Chinese medicinal granule in this embodiment will be described centering on the differences from example 2.
In the process implemented in embodiment 2, after the drug pellets are made into drug pellets, the drug pellets may not be coated with the drug powder, and the drug pellets are processed into composite pellet products, and the drug pellets need to be coated with the drug powder manually, so that the compound mixer implemented in embodiment 2 is provided, as shown in fig. 9, in the compound hopper 28, a collecting hopper 27 is matched and sleeved, the collecting hopper 27 is of a mesh structure, one end of a swinging rod 29 is fixed on a gear shaft of an auxiliary gear 30, the auxiliary gear is rotationally sleeved on a fixed plate 26, the free end of the swinging rod is sleeved on a bottom rotating shaft of the compound hopper 28, a driving gear 31 at the output end of the motor is meshed with the auxiliary gear, and adjacent compound hoppers are fixedly connected through a connecting rod 32, the drug pellets are firstly conveyed into the collecting hopper 27, spraying of an adhesive is performed, and the powder is placed in the compound hopper 28, and after the collecting hopper 27 is placed into the compound hopper 28, the driving gear 31 is rotationally meshed with a transmission gear, the gear is rotationally driven to drive the auxiliary hopper 27, so that the compound hopper connected with the drug powder swings around the tooth shaft of the auxiliary gear 30, and the bottom of the compound hopper is uniformly mixed into the composite pellets, and the compound pellets are processed.
On the basis of the above embodiment, fig. 10 is a schematic diagram of steps of producing granules by using a traditional Chinese medicine granule production system according to the present invention, and a production method by using the traditional Chinese medicine granule production system includes the following steps:
step S1, starting a production system by workers, putting concentrated and purified medicinal material powder into a feed inlet 2, enabling the medicinal material powder to enter a mixing channel 1 through the feed inlet 2, respectively outputting water and a coagulant into the mixing channel 1 by a water delivery nozzle 3 and an additive nozzle 4 at the side edge of the feed inlet 2, mixing the medicinal material powder in the mixing channel 1, uniformly stirring the medicinal material powder by a double auger arranged in the mixing channel 1, and conveying the medicinal material powder to a blank making channel in a spiral manner;
s2, under the operation of a cake pressing assembly and a blank making assembly, the medicine mixture entering the blank making channel is firstly rolled and cut into uniform medicine cakes, then is further cut into medicine blanks with the same particle size, and the medicine blanks are demoulded and thrown out after being heated and dried;
step S3, after screening the thrown drug blanks, screening qualified drug blanks, enabling the screened drug blanks to enter a pelleting disc 251, controlling three motors to start at the moment, enabling the arc-shaped fixed arms to drive the articulated arms by the motors with different rotating speeds and different steering directions, enabling the pelleting disc 251 to continuously shake circumferentially around a shaft seat 257 under the mutual coordination of the articulated arms 2511, enabling the inside drug blanks to be rolled into pellets, screening out the drug pellets conforming to the particle size through sieve holes at the bottom in the pelleting disc 251, and repeating the steps S1 to S3 to continuously produce the drug pellets.
In this embodiment, the preparation process of the concentrated and purified medicinal powder is as follows: taking 140 jin of medicinal materials, adding enough water for decoction for 2 times, wherein the first time is 110 minutes, the second time is 80 minutes, merging the medicinal liquid obtained by the two times of decoction, filtering and concentrating until the relative density of the medicinal liquid is 1.1, adding ethanol to enable the alcohol concentration to be 60%, standing for 6-8 hours, filtering and concentrating again until the relative density of the medicinal liquid is 1.14, and finally carrying out spray drying on the concentrated medicinal liquid to obtain corresponding medicinal material powder.
The traditional Chinese medicine granule produced by the traditional Chinese medicine granule production system and the corresponding production method has the advantages of uniform content of medicine in granules, good consistency of particle size and high quality of finished products.
The foregoing description of the preferred embodiments of the invention is not intended to limit the invention to the particular embodiments disclosed, but on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention.

Claims (9)

1. The qi-tonifying and health-protecting asthma-preventing granule is characterized by being prepared from the following raw materials in parts by weight: 20-35 parts of astragalus membranaceus, 6-15 parts of bighead atractylodes rhizome, 6-15 parts of divaricate saposhnikovia root, 6-15 parts of cassia twig, 6-15 parts of white paeony root, 6-15 parts of ginger, 6-15 parts of Chinese date, 7-12 parts of liquorice, 6-15 parts of rhizoma curculiginis and 6-15 parts of herba epimedii.
2. The qi-tonifying, defending and asthma-preventing granule of claim 1, wherein: in the medicinal materials, the weight ratio of the bighead atractylodes rhizome to the divaricate saposhnikovia root to the cassia twig is 1:1:1.
3. The production system of the qi-tonifying defending anti-wheezing particles according to claim 1, comprising a mixing channel, wherein a feed inlet is formed in the mixing channel, a water delivery nozzle and an additive nozzle are arranged, and at least one pair of augers is arranged in the mixing channel, and the production system is characterized in that: the novel biscuit manufacture device comprises a biscuit manufacture device, and is characterized by further comprising a biscuit manufacture assembly and a biscuit manufacture assembly, wherein a redundant area is arranged at the upper end of a mixing channel in an inclined mode, a biscuit manufacture channel is arranged at the lower end of the mixing channel in a downward mode, the biscuit manufacture assembly comprises a biscuit manufacture roller sleeved on the support sleeve in a bilateral symmetry mode, the biscuit manufacture assembly comprises a main die roller arranged below the biscuit manufacture roller in a staggered mode, an upper guide plate is arranged between the biscuit manufacture roller and the main die roller, the main die roller body comprises a support sleeve, a die sleeve ring is coated on the outer peripheral side of the support sleeve, a notch section is arranged on the support sleeve, an inner cylinder is axially arranged in the support sleeve and connected with a hub between the inner cylinder and the support sleeve, a heating piece is arranged in the inner cylinder, a central fixed shaft of the inner cylinder is fixed in the biscuit manufacture channel, the die sleeve is sleeved on the support sleeve in a rotating mode, tooth rings are arranged at the two ends of the die sleeve in an extending mode, an outer top roller is arranged at the notch section of the support sleeve, a plurality of spike teeth are uniformly distributed on the outer top roller, the spike teeth are meshed in the die sleeve in a matched mode, an inner shaft of the outer top roller rotates in the biscuit manufacture channel, and the main gear at two ends of the inner shaft are meshed with the tooth rings, and the tooth rings are meshed with the die rings, and are used for driving the die sleeve.
4. The production system of qi-tonifying, defending and anti-wheezing granules according to claim 1, wherein: an auxiliary roller for assisting in rolling the mould lantern ring is arranged on the side edge of the main mould roller, and the output end of the blank making grain channel is in butt joint with an external screening piece; the blank making grain channel is transversely provided with a flat hole corresponding to the roll shaft of any one cake pressing roll, the roll shaft of the cake pressing roll is matched and arranged in the flat hole, the cake pressing roll can slide in the flat hole through the roll shaft, the cake pressing gap is adjusted, and the flat hole is provided with a locking block for fixing the roll shaft; the mould lantern ring comprises a plurality of uniformly distributed inner grooves, and the mould lantern ring is integrally and rotatably sleeved on the supporting sleeve.
5. The production system of the qi-tonifying and anti-asthma granules according to claim 3, wherein the heating piece is a heating wire, a plurality of heating holes are formed in the inner cylinder, the heating wire is correspondingly placed in the heating holes, and the heating wire conducts heat to the copper supporting sleeve through the hub so as to semi-dry the medicine blank granules in the die sleeve ring.
6. A production system of granules for protecting and protecting against asthma according to claim 3, wherein the notch section is located at the left lower side of the supporting sleeve, a lower deflector is arranged at the outer side of the notch section of the supporting sleeve, the lower deflector has an arc-shaped structure, and the lower deflector corresponds to the notch section of the supporting sleeve.
7. A system for producing particles for use in a gas-supplementing and gas-protecting and anti-wheezing device according to claim 3, wherein an end plate is provided between the main gear and the support sleeve, the end plate is fixed on the central fixed shaft, and the end plate is provided with an annular hole corresponding to a toothed ring, the toothed ring is meshed with the main gear through the annular hole, the end plate is integrally larger than the main mold roller, and the main gear drives the toothed ring to rotate the mold collar on the circular support plate.
8. The production method of the qi-tonifying and health-protecting asthma-preventing granule is characterized by comprising the following steps of:
step S1, starting a production system by workers, putting concentrated and purified medicinal material powder into a feed inlet, enabling the medicinal material powder to enter a mixing channel through the feed inlet, respectively outputting water and a coagulant into the mixing channel by a water delivery nozzle and an additive nozzle at the side edge of the feed inlet, mixing the medicinal material powder with the medicinal material powder in the mixing channel, uniformly stirring the medicinal material powder by a double auger arranged in the mixing channel, and conveying the medicinal material powder to a blank making channel in a spiral manner;
s2, under the operation of a cake pressing assembly and a blank making assembly, the medicine mixture entering the blank making channel is firstly rolled and cut into uniform medicine cakes, then is further cut into medicine blanks with the same particle size, and the medicine blanks are demoulded and thrown out after being heated and dried;
step S3, screening the screened qualified drug blanks, enabling the screened qualified drug blanks to enter a pellet making disc, controlling three motors to start at the moment, enabling the arc-shaped fixed arms to drive the hinged arms by the motors with different rotating speeds and directions, enabling the pellet making disc to continuously shake circumferentially around the shaft seat under the mutual cooperation of the hinged arms, enabling the internal drug blanks to be rolled into pellets, screening out the drug pellets conforming to the particle size through sieve holes at the bottom in the pellet making disc, and repeating the steps S1 to S3 to continuously produce the drug pellets.
9. The production method of the qi-tonifying, defending and asthma-preventing particles according to claim 8, wherein the preparation process of the concentrated and purified medicinal powder is as follows: taking 140 jin of medicinal materials according to the weight ratio, adding enough water for decoction for 2 times, wherein the first time is 110 minutes, the second time is 80 minutes, merging the liquid medicine obtained by the two times of decoction, filtering and concentrating until the relative density of the liquid medicine is 1.1, adding ethanol to enable the alcohol concentration to be 60%, standing for 6-8 hours, filtering and concentrating again until the relative density of the liquid medicine is 1.14, and finally carrying out spray drying on the concentrated liquid medicine to obtain corresponding medicinal material powder.
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