CN116159099A - Preparation method of decoction pieces of hundred medicines - Google Patents
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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Abstract
The invention discloses a preparation method of a hundred-medicine decoction piece, which comprises the following steps of: vinasse: the tea leaves are respectively cleaned and removed from non-medicinal parts, rotten medicinal materials and impurities at the ratio of 100:25:6.2; crushing gallnut; putting the crushed gallnut into a drying box for drying; screening crushed and dried gallnut with a 24-mesh screen, and screening out black brown aphids and gray powdery excrement; pulverizing Galla chinensis to 100 mesh, pulverizing distiller's grains to 50 mesh, adding folium Camelliae sinensis into jacketed kettle, decocting for multiple times, and concentrating to obtain fluid extract; mixing Galla chinensis powder, pulvis Cornus Bubali Concentratus and fluid extract, and fermenting in a fermentation tray; placing the fermented material in a drying chamber for drying, and controlling the water content of the material to be 28.00% -29.00%; the materials are made into strips with the diameter of 5-10mm by using extrusion strip making equipment, cut into pieces with the diameter of 3-8mm by using cutting equipment, and dried at the temperature of 50-70 ℃ has the advantages of high forming rate and good forming effect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a preparation method of decoction pieces of hundred medicines.
Background
The decoction of the Chinese herbal medicines is a traditional Chinese herbal medicine decoction piece prepared by natural fermentation of Chinese gall, tea, vinasse and the like, and is originally carried out in Danxi Xin method. The decoction is a block filled with white frost, has sweet and sour taste, has effects of moistening lung, resolving phlegm, stopping bleeding, relieving diarrhea, relieving fever, promoting salivation, etc., and can be used for treating cough due to lung deficiency, chronic diarrhea, chronic dysentery, hematochezia, hemorrhoid blood, carbuncle, swelling, sore, skin, and skin wet and rot. The main raw materials of the hundred-medicine decoction are gallnuts, the gallnuts contain a large amount of tannin components and a small amount of gallic acid, the content of the tannin in the gallnuts is not less than 50% and even is more than 70% specified in pharmacopoeia of the people's republic of China of 2015 edition. Tannins are reported to have hepatotoxicity, and gallic acid generated by fermentation and conversion has the effects of resisting tumor, killing trypanosome, resisting inflammation, inhibiting bacteria, resisting virus, reducing blood sugar and reducing ester and the like, and the tannins are hydrolyzed to generate the gallic acid under the action of tannase and microorganisms in the process of fermenting gallnut into hundred medicines, so that the gallic acid is a material basis for changing the efficacy of the gallic acid.
In clinical medication, traditional Chinese herbal pieces decocted by hundred medicines are prepared into a lozenge, so that the problem of quantitative taking of the decocted hundred medicines is solved, and the decoction is convenient for patients to carry and store, but the existing decoction production process of the hundred medicines has the problems of high material viscosity, inconvenient operation and difficult molding.
Disclosure of Invention
The invention aims to provide a preparation method of a hundred-medicine decoction piece, which has the advantages of high molding rate and good molding effect.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: a preparation method of a hundred-medicine decoction piece comprises the following steps: s1, gallnut: vinasse: the tea leaves are respectively cleaned and removed from non-medicinal parts, rotten medicinal materials and impurities at the ratio of 100:25:6.2;
s2, crushing the cleaned gallnut by using a crusher, wherein the crushed gallnut has no complete capsule shell;
s3, putting the crushed gallnut into a drying box, drying for 1-2 hours at the temperature of 50-60 ℃, and turning over the gallnut in the drying process;
s4, screening the crushed and dried gallnut with a 24-mesh screen, and screening off blackish brown aphids and gray powdery excreta;
s5, passing the crushed gallnut through a 100-mesh screen, and continuously crushing the gallnut which does not pass through the 100-mesh screen until the gallnut passes through the 100-mesh screen; then, the crushed vinasse passes through a 50-mesh screen, and the vinasse is continuously crushed without passing through the 50-mesh screen until the vinasse passes through the 50-mesh screen;
s6, putting tea leaves into a jacketed kettle, adding clear water which is 15 times the weight of the tea leaves into the jacketed kettle, heating the jacketed kettle, boiling the water, decocting for 20 minutes, and filtering the liquid medicine by using a 80-mesh screen;
s7, repeating the step S6 for two times, and combining the three decoctions;
s8, adding the combined decoction into a concentrator, and concentrating to obtain fluid extract with the amount of 1-1.2 times that of the fine powder of the gallnut;
s9, pouring the fine powder of the gallnut and the wine groove powder into a groove type mixer, adding the clear paste after mixing until the color is uniform, and continuing mixing for 5-10 minutes to ensure uniform mixing, no dry powder and no core wrapping;
s10, spreading the soft materials mixed in the step S9 in a fermentation tray, fermenting for 3-9 days at the temperature of 20-45 ℃ and the humidity of 80-90%, and taking out when the mould coating grows out in the fermentation process, continuing fermenting until the surface is spread over the white mould coating;
s11, placing the fermented material in the step S10 in a drying chamber for drying, and controlling the water content of the material to be 28.00% -29.00%;
s12, using extrusion strip-making equipment to make the material into strips with the diameter of 5-10mm, cutting the strips into pieces with the diameter of 3-8mm by using cutting equipment, and drying at the temperature of 50-70 ℃.
Further, in step S2, the size of the gallic acid powder is 100-140 mesh.
Further, in step S5, the size of the distillers' grains powder is 50-80 meshes.
Further, in step S8, the ratio of gallnut to fluid extract is 1:1.
Compared with the prior art, the invention has the advantages that: before extrusion molding of the material, the water content of the material is controlled to be 28.00% -29.00%, so that the material is prevented from being bonded, and the molding rate and the molding effect of the material are improved.
Drawings
FIG. 1 is a sample No. 2 molding diagram;
FIG. 2 is a sample No. 3 molding diagram;
FIG. 3 is a sample No. 4 molding diagram;
FIG. 4 is a sample No. 5 molding diagram;
FIG. 5 is a sample No. 6 molding diagram;
FIG. 6 is a sample No. 7 molding diagram;
FIG. 7 is a sample No. 8 molding chart.
Detailed Description
The present invention will be further described below.
Examples: a preparation method of a hundred-medicine decoction piece comprises the following steps: s1, gallnut: vinasse: the tea leaves are respectively cleaned and removed from non-medicinal parts, rotten medicinal materials and impurities at the ratio of 100:25:6.2;
s2, crushing the cleaned gallnut by using a crusher, wherein the crushed gallnut has no complete capsule shell;
s3, putting the crushed gallnut into a drying box, drying for 1-2 hours at the temperature of 50-60 ℃, and turning over the gallnut in the drying process;
s4, screening the crushed and dried gallnut with a 24-mesh screen, and screening off blackish brown aphids and gray powdery excreta;
s5, passing the crushed gallnut through a 100-mesh screen, and continuously crushing the gallnut which does not pass through the 100-mesh screen until the gallnut passes through the 100-mesh screen; then, the crushed vinasse passes through a 50-mesh screen, and the vinasse is continuously crushed without passing through the 50-mesh screen until the vinasse passes through the 50-mesh screen;
s6, putting tea leaves into a jacketed kettle, adding clear water which is 15 times the weight of the tea leaves into the jacketed kettle, heating the jacketed kettle, boiling the water, decocting for 20 minutes, and filtering the liquid medicine by using a 80-mesh screen;
s7, repeating the step S6 for two times, and combining the three decoctions;
s8, adding the combined decoction into a concentrator, and concentrating to obtain fluid extract with the amount of 1-1.2 times that of the fine powder of the gallnut;
s9, pouring the fine powder of the gallnut and the wine groove powder into a groove type mixer, adding the clear paste after mixing until the color is uniform, and continuing mixing for 5-10 minutes to ensure uniform mixing, no dry powder and no core wrapping;
s10, spreading the soft materials mixed in the step S9 in a fermentation tray, fermenting for 3-9 days at the temperature of 20-45 ℃ and the humidity of 80-90%, and taking out when the mould coating grows out in the fermentation process, continuing fermenting until the surface is spread over the white mould coating;
s11, placing the fermented material in the step S10 in a drying chamber for drying, and controlling the water content of the material to be 28.00% -29.00%;
s12, using extrusion strip-making equipment to make the material into strips with the diameter of 5-10mm, cutting the strips into pieces with the diameter of 3-8mm by using cutting equipment, and drying at the temperature of 50-70 ℃.
Further, in step S2, the size of the gallic acid powder is 100-140 mesh.
Further, in step S5, the size of the distillers' grains powder is 50-80 meshes.
Further, in step S8, the ratio of gallnut to fluid extract is 1:1.
The effect of different water contents on material formation is shown in Table 1
TABLE 1 Material Forming results Table
As shown in Table 1, the molding effect was best when the moisture content of the material was 28.93%.
The principles and embodiments of the present invention have been described herein with reference to specific examples, the description of which is intended only to assist in understanding the methods of the present invention and the core ideas thereof; also, it will be apparent to those skilled in the art from this disclosure that various changes and modifications can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (4)
1. A preparation method of a hundred-medicine decoction piece is characterized by comprising the following steps: the method comprises the following steps: s1, gallnut: vinasse: the tea leaves are respectively cleaned and removed from non-medicinal parts, rotten medicinal materials and impurities at the ratio of 100:25:6.2;
s2, crushing the cleaned gallnut by using a crusher, wherein the crushed gallnut has no complete capsule shell;
s3, putting the crushed gallnut into a drying box, drying for 1-2 hours at the temperature of 50-60 ℃, and turning over the gallnut in the drying process;
s4, screening the crushed and dried gallnut with a 24-mesh screen, and screening off blackish brown aphids and gray powdery excreta;
s5, passing the crushed gallnut through a 100-mesh screen, and continuously crushing the gallnut which does not pass through the 100-mesh screen until the gallnut passes through the 100-mesh screen; then, the crushed vinasse passes through a 50-mesh screen, and the vinasse is continuously crushed without passing through the 50-mesh screen until the vinasse passes through the 50-mesh screen;
s6, putting tea leaves into a jacketed kettle, adding clear water which is 15 times the weight of the tea leaves into the jacketed kettle, heating the jacketed kettle, boiling the water, decocting for 20 minutes, and filtering the liquid medicine by using a 80-mesh screen;
s7, repeating the step S6 for two times, and combining the three decoctions;
s8, adding the combined decoction into a concentrator, and concentrating to obtain fluid extract with the amount of 1-1.2 times that of the fine powder of the gallnut;
s9, pouring the fine powder of the gallnut and the wine groove powder into a groove type mixer, adding the clear paste after mixing until the color is uniform, and continuing mixing for 5-10 minutes to ensure uniform mixing, no dry powder and no core wrapping;
s10, spreading the soft materials mixed in the step S9 in a fermentation tray, fermenting for 3-9 days at the temperature of 20-45 ℃ and the humidity of 80-90%, and taking out when the mould coating grows out in the fermentation process, continuing fermenting until the surface is spread over the white mould coating;
s11, placing the fermented material in the step S10 in a drying chamber for drying, and controlling the water content of the material to be 28.00% -29.00%;
s12, using extrusion strip-making equipment to make the material into strips with the diameter of 5-10mm, cutting the strips into pieces with the diameter of 3-8mm by using cutting equipment, and drying at the temperature of 50-70 ℃.
2. The method for preparing the hundred-medicine decoction pieces according to claim 1, wherein: in the step S2, the size of the gallic acid powder is 100-140 meshes.
3. The method for preparing the hundred-medicine decoction pieces according to claim 1, wherein: in the step S5, the size of the vinasse powder is 50-80 meshes.
4. The method for preparing the hundred-medicine decoction pieces according to claim 1, wherein: in the step S8, the ratio of the gallnut to the clear paste is 1:1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202310152063.8A CN116159099A (en) | 2023-02-22 | 2023-02-22 | Preparation method of decoction pieces of hundred medicines |
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| CN202310152063.8A CN116159099A (en) | 2023-02-22 | 2023-02-22 | Preparation method of decoction pieces of hundred medicines |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116603038A (en) * | 2023-06-25 | 2023-08-18 | 苏州市天灵中药饮片有限公司 | Lees preparation technology capable of shortening hundred-medicine decoction fermentation period |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109971637A (en) * | 2019-01-17 | 2019-07-05 | 北京金崇光药业有限公司 | Fermentation system containing automatic charging device and fermented Chinese gall herb and tea leaves processing procedure |
| CN211584307U (en) * | 2019-12-30 | 2020-09-29 | 北京金崇光药业有限公司 | Novel extruder |
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2023
- 2023-02-22 CN CN202310152063.8A patent/CN116159099A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109971637A (en) * | 2019-01-17 | 2019-07-05 | 北京金崇光药业有限公司 | Fermentation system containing automatic charging device and fermented Chinese gall herb and tea leaves processing procedure |
| CN211584307U (en) * | 2019-12-30 | 2020-09-29 | 北京金崇光药业有限公司 | Novel extruder |
Non-Patent Citations (1)
| Title |
|---|
| 王瑞生等: "基于肠道菌群及肠黏膜屏障功能探索百药煎治疗溃疡性结肠炎的作用机制", 《中国实验方剂学杂志》, vol. 27, no. 20, pages 46 - 54 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116603038A (en) * | 2023-06-25 | 2023-08-18 | 苏州市天灵中药饮片有限公司 | Lees preparation technology capable of shortening hundred-medicine decoction fermentation period |
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