CN1161368C - Production method of phycocolloid oligosaccharide - Google Patents
Production method of phycocolloid oligosaccharide Download PDFInfo
- Publication number
- CN1161368C CN1161368C CNB011079525A CN01107952A CN1161368C CN 1161368 C CN1161368 C CN 1161368C CN B011079525 A CNB011079525 A CN B011079525A CN 01107952 A CN01107952 A CN 01107952A CN 1161368 C CN1161368 C CN 1161368C
- Authority
- CN
- China
- Prior art keywords
- oligosaccharide
- algin
- manufacture method
- oligosaccharides
- production method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229920001542 oligosaccharide Polymers 0.000 title claims abstract description 26
- 150000002482 oligosaccharides Chemical class 0.000 title claims abstract description 22
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 20
- 229920000615 alginic acid Polymers 0.000 claims abstract description 20
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical group OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000005903 acid hydrolysis reaction Methods 0.000 claims abstract description 4
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 4
- 238000000926 separation method Methods 0.000 claims abstract description 3
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims description 9
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 230000007062 hydrolysis Effects 0.000 claims description 3
- 238000006460 hydrolysis reaction Methods 0.000 claims description 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
- 229920000936 Agarose Polymers 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 229940072056 alginate Drugs 0.000 claims description 2
- 229920002401 polyacrylamide Polymers 0.000 claims description 2
- 230000001590 oxidative effect Effects 0.000 abstract description 4
- 239000012505 Superdex™ Substances 0.000 abstract description 2
- 239000002253 acid Substances 0.000 abstract description 2
- 239000007800 oxidant agent Substances 0.000 abstract 3
- 239000005708 Sodium hypochlorite Substances 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 235000010408 potassium alginate Nutrition 0.000 abstract 1
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 abstract 1
- 239000000737 potassium alginate Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- -1 oligosaccharides calcium salt Chemical class 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- WFIYPADYPQQLNN-UHFFFAOYSA-N 2-[2-(4-bromopyrazol-1-yl)ethyl]isoindole-1,3-dione Chemical compound C1=C(Br)C=NN1CCN1C(=O)C2=CC=CC=C2C1=O WFIYPADYPQQLNN-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- AEMOLEFTQBMNLQ-UHFFFAOYSA-N beta-D-galactopyranuronic acid Natural products OC1OC(C(O)=O)C(O)C(O)C1O AEMOLEFTQBMNLQ-UHFFFAOYSA-N 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB011079525A CN1161368C (en) | 2001-04-07 | 2001-04-07 | Production method of phycocolloid oligosaccharide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB011079525A CN1161368C (en) | 2001-04-07 | 2001-04-07 | Production method of phycocolloid oligosaccharide |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1380342A CN1380342A (en) | 2002-11-20 |
CN1161368C true CN1161368C (en) | 2004-08-11 |
Family
ID=4656848
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB011079525A Expired - Fee Related CN1161368C (en) | 2001-04-07 | 2001-04-07 | Production method of phycocolloid oligosaccharide |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1161368C (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1562050A (en) | 2004-03-24 | 2005-01-12 | 中国海洋大学 | Use of oligose alginate in anti-dementia and anti-diabetes |
CN100372542C (en) * | 2004-04-16 | 2008-03-05 | 中国海洋大学 | Use of algin oligocauharide as prebiotics |
CN1321139C (en) * | 2004-11-22 | 2007-06-13 | 青岛明月海藻集团有限公司 | Production process of algin oligose |
CN1920002B (en) * | 2005-08-22 | 2011-06-08 | 中国海洋大学 | Novel vibrionaceae vibrio bacterial strain and application thereof |
CN101037456B (en) * | 2007-04-24 | 2010-05-26 | 宁波大学 | Preparation method of alginate oligosaccharides |
WO2009086685A1 (en) * | 2007-12-29 | 2009-07-16 | Dalian Yaweite Bioengineering Co., Ltd. | An alginic acid with low molecular weight, its salts, uses, preparative methods, pharmaceutical compositions and foods |
CN102391317A (en) * | 2011-08-05 | 2012-03-28 | 宁夏万胜生物工程有限公司 | Method for separating alginate-derived oligosaccharides from alginate-derived oligosaccharide fermentation liquor |
-
2001
- 2001-04-07 CN CNB011079525A patent/CN1161368C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1380342A (en) | 2002-11-20 |
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Owner name: QINGDAO OCEAN UNIVERSITY OF CHINA HOLDINGS CO., LT Free format text: FORMER OWNER: QINGDAO OCEANOLOGY UNIV. Effective date: 20130427 |
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Free format text: CORRECT: ADDRESS; FROM: 266003 QINGDAO, SHANDONG PROVINCE TO: 266071 QINGDAO, SHANDONG PROVINCE |
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Effective date of registration: 20130427 Address after: 266071 Hongkong East Road, Laoshan District, Shandong, China, No. 23, No. Patentee after: Qingdao Ocean University of China Holdings Limited Address before: 266003 No. 5 fish Hill Road, Shandong, Qingdao Patentee before: Qingdao Oceanology Univ. |
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ASS | Succession or assignment of patent right |
Owner name: QINGDAO HAIDA HAITANG BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: QINGDAO OCEAN UNIVERSITY OF CHINA HOLDINGS CO., LTD. Effective date: 20130927 |
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C41 | Transfer of patent application or patent right or utility model | ||
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Free format text: CORRECT: ADDRESS; FROM: 266071 QINGDAO, SHANDONG PROVINCE TO: 266061 QINGDAO, SHANDONG PROVINCE |
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TR01 | Transfer of patent right |
Effective date of registration: 20130927 Address after: 1704 room 182-6, Fortune Tower, No. 266061 Haier Road, Laoshan District, Shandong, Qingdao Patentee after: Qingdao haidahai sugar Biotechnology Co. Ltd. Address before: 266071 Hongkong East Road, Laoshan District, Shandong, China, No. 23, No. Patentee before: Qingdao Ocean University of China Holdings Limited |
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EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20021120 Assignee: QINGDAO BZ OLIGO BIOTECH CO., LTD. Assignor: Qingdao haidahai sugar Biotechnology Co. Ltd. Contract record no.: 2014370000031 Denomination of invention: Production method of phycocolloid oligosaccharide Granted publication date: 20040811 License type: Exclusive License Record date: 20140324 |
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