CN116077172A

CN116077172A - Method and device for testing radio frequency ablation and system for testing radio frequency ablation

Info

Publication number: CN116077172A
Application number: CN202310202996.3A
Authority: CN
Inventors: 颜莹; 崔长杰; 徐宏
Original assignee: Hangzhou Kunbo Biotechnology Co Ltd
Current assignee: Hangzhou Kunbo Biotechnology Co Ltd
Priority date: 2023-03-06
Filing date: 2023-03-06
Publication date: 2023-05-09

Abstract

The application provides a method and a device for testing radio frequency ablation and a system for testing radio frequency ablation, comprising the following steps: ablating the target object by adopting pulse voltage; in the ablation process, obtaining target impedance corresponding to a target object; controlling the perfusion equipment to perfuse the target object according to a preset perfusion mode under the condition that the target impedance is not greater than a first threshold value; and under the condition that the target impedance is larger than a first threshold value, adjusting a preset pouring mode so that the pouring equipment can pour the target object according to the adjusted pouring mode. The method and the device ensure that the current passing through the focus tissue contained in the target object is not too small due to the overlarge target impedance, so that the thermal efficacy on the focus tissue contained in the target object in the ablation process is always stronger, and the better ablation effect is ensured.

Description

Method and device for testing radio frequency ablation and system for testing radio frequency ablation

Technical Field

The application relates to the technical field of radio frequency ablation, in particular to a radio frequency ablation testing method, a device, a computer readable storage medium, a processor and a radio frequency ablation testing system.

Background

The radio frequency ablation technology is widely applied, and a common ablation control method is constant voltage ablation, wherein the constant voltage ablation is performed by adopting a voltage pulse mode, and an infusion pump is controlled to perform normal saline infusion for a specified time at a specified flow rate in a fixed period in the ablation process.

The control of the conventional constant-voltage ablation infusion pump only controls the infusion pump to perform normal saline infusion for a specified time according to a set fixed period and a specified flow, so that the effect is poor.

Disclosure of Invention

The main objective of the present application is to provide a method and apparatus for testing radiofrequency ablation, a computer readable storage medium, a processor and a system for testing radiofrequency ablation, so as to solve the problem of poor ablation effect of a constant-pressure ablation method in the prior art.

According to an aspect of an embodiment of the present application, there is provided a method for testing radio frequency ablation, including: ablating the target object by adopting pulse voltage; in the ablation process, acquiring target impedance corresponding to the target object; controlling a perfusion device to perfuse the target object according to a preset perfusion mode under the condition that the target impedance is not greater than a first threshold value; and under the condition that the target impedance is larger than the first threshold value, adjusting the preset pouring mode so that the pouring equipment can pour the target object according to the adjusted pouring mode.

Optionally, adjusting the preset perfusion mode if the target impedance is greater than the first threshold value includes: controlling the perfusion apparatus to be started and to continuously perfuse the cooling medium to the target object at a preset flow rate for a first preset time period under the condition that the target impedance is larger than the first threshold value; and under the condition that the target impedance is larger than the first threshold value after the first preset time period of pouring, acquiring the change rate of the target impedance, and adjusting the pouring flow rate of the pouring equipment according to the change rate and the current flow rate of the pouring equipment so as to reduce the target impedance corresponding to the target object.

Optionally, adjusting the perfusion flow rate of the perfusion apparatus according to the rate of change and the current flow rate of the perfusion apparatus includes: reducing the current flow rate of the perfusion apparatus to obtain a target flow rate when the rate of change is less than a second threshold; and under the condition that the change rate is not smaller than the second threshold value, increasing the current flow rate of the perfusion equipment to obtain the target flow rate.

Optionally, increasing the current flow rate of the perfusion apparatus to obtain the target flow rate if the rate of change is not less than the second threshold value includes: determining that the target flow rate is the sum of the current flow rate and a first preset value under the condition that the change rate is not smaller than the second threshold value and smaller than a third threshold value; determining that the target flow rate is the sum of the current flow rate and a second preset value under the condition that the change rate is not smaller than the third threshold value and smaller than a fourth threshold value; determining that the target flow rate is the sum of the current flow rate and a third preset value under the condition that the change rate is not smaller than the fourth threshold value and smaller than a fifth threshold value; and under the condition that the change rate is not smaller than the fifth threshold value, determining that the target flow rate is the sum of the current flow rate and a fourth preset value, wherein the first preset value, the second preset value, the third preset value and the fourth preset value are sequentially increased, and the target flow rate is not larger than the flow rate threshold value.

Optionally, in the case that the rate of change is less than a second threshold, reducing the current flow rate of the perfusion apparatus to obtain a target flow rate, including: determining the target flow rate as a difference between the current flow rate and a fifth preset value when the current flow rate of the perfusion apparatus is greater than the predetermined flow rate; and determining that the target flow rate is the preset flow rate under the condition that the current flow rate is not larger than the preset flow rate.

Optionally, controlling the perfusion device to perfuse the target object according to a preset perfusion mode under the condition that the target impedance is not greater than a first threshold value includes: controlling the perfusion equipment to be started and perfusing the cooling medium to the target object at a preset flow rate under the condition that the target impedance is not greater than the first threshold value and the closing time of the perfusion equipment reaches a second preset time; and controlling the perfusion equipment to be closed under the condition that the perfusion time length reaches a fourth preset time length.

Optionally, ablating the target object with the pulsed voltage includes: outputting a preset voltage to ablate the target object; stopping outputting the predetermined voltage when the ablation duration reaches a fifth predetermined duration or when the target impedance is not less than a sixth threshold; and re-outputting the preset voltage to ablate the target object under the condition that the idle time length reaches a sixth preset time length or the target impedance is not larger than a seventh threshold value, wherein the seventh threshold value is smaller than the sixth threshold value, the ablation time length is used for recording the time length of continuously outputting the preset voltage each time, and the idle time length is used for recording the time length of stopping outputting the preset voltage each time.

According to another aspect of the embodiments of the present application, there is also provided a test device for radio frequency ablation, including: the ablation unit is used for ablating the target object by adopting pulse voltage; the acquisition unit is used for acquiring target impedance corresponding to the target object in an ablation process; the control unit is used for controlling the perfusion equipment to perfuse the target object according to a preset perfusion mode under the condition that the target impedance is not greater than a first threshold value; and the adjusting unit is used for adjusting the preset pouring mode under the condition that the target impedance is larger than the first threshold value, so that the pouring equipment is used for pouring the target object according to the adjusted pouring mode.

According to still another aspect of the inventive embodiment, there is also provided a computer-readable storage medium including a stored program, wherein the program performs any one of the methods.

According to yet another aspect of the embodiments of the present application, there is also provided a processor, where the processor is configured to execute a program, and where the program executes any one of the methods.

According to another aspect of the embodiments of the present application, there is also provided a test system for radio frequency ablation, including: a radio frequency ablation device; the controller of the radio frequency ablation device comprises one or more processors, a memory, and one or more programs, wherein the one or more programs are stored in the memory and configured to be executed by the one or more processors, the one or more programs comprising instructions for performing any of the methods.

By adopting the technical scheme, firstly, a target object is ablated by adopting pulse voltage, and in the ablation process, the target impedance corresponding to the target object is obtained; controlling a perfusion device to perfuse the target object according to a preset perfusion mode under the condition that the target impedance is not greater than a first threshold value; and adjusting the preset pouring mode under the condition that the target impedance is larger than the first threshold value, and controlling the pouring equipment to pour the target object according to the adjusted pouring mode so as to adjust the target impedance. Compared with the problems of insufficient thermal efficacy and poor ablation effect caused by overlarge impedance and constant voltage of a target object in a constant-voltage ablation process in the prior art, the radio frequency ablation method provided by the application ablates the target object through pulse voltage and adopts a preset perfusion mode, when the target impedance in the ablation process is overlarge, the effect of adjusting the target impedance in the ablation process is achieved by adjusting the preset perfusion mode, so that the adjusted target impedance is not overlarge, the current passing through the focus tissue contained in the target object is ensured not to be overlarge and is overlarge due to overlarge target impedance, the thermal efficacy of the focus tissue contained in the target object in the ablation process is always stronger, and the ablation effect is ensured to be better.

Drawings

The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this application, illustrate embodiments of the application and together with the description serve to explain the application and do not constitute an undue limitation to the application. In the drawings:

FIG. 1 shows a block diagram of a hardware architecture of a mobile terminal according to a test method for performing radio frequency ablation provided in an embodiment of the present application;

FIG. 2 illustrates a flow diagram of a method of testing radio frequency ablation provided in accordance with an embodiment of the present application;

FIG. 3 illustrates a voltage control flow diagram of a method of testing radio frequency ablation according to an embodiment of the present application;

FIG. 4 illustrates an infusion control flow chart of a test method of radio frequency ablation according to an embodiment of the present application;

FIG. 5 shows a model diagram of voltage ablation by a prior art radio frequency ablation method;

FIG. 6 shows a model diagram of voltage ablation by a test method of radio frequency ablation according to an embodiment of the present application;

fig. 7 shows a block diagram of a radio frequency ablation testing device provided according to an embodiment of the present application.

Wherein the figures include the following reference numerals:

102. a processor; 104. a memory; 106. a transmission device; 108. and an input/output device.

Detailed Description

It should be noted that, in the case of no conflict, the embodiments and features in the embodiments may be combined with each other. The present application will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.

In order to make the present application solution better understood by those skilled in the art, the following description will be made in detail and with reference to the accompanying drawings in the embodiments of the present application, it is apparent that the described embodiments are only some embodiments of the present application, not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art based on the embodiments herein without making any inventive effort, shall fall within the scope of the present application.

It should be noted that the terms "first," "second," and the like in the description and claims of the present application and in the drawings are used for distinguishing between similar objects and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used may be interchanged where appropriate in order to describe the embodiments of the present application described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

As described in the background art, the constant-pressure ablation method in the prior art has poor ablation effect, and in order to solve the above problems, embodiments of the present application provide a method, a device, a computer-readable storage medium, a processor, and a system for testing radio frequency ablation.

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.

The method embodiments provided in the embodiments of the present application may be performed in a mobile terminal, a computer terminal or similar computing device. Taking the mobile terminal as an example, fig. 1 is a block diagram of a hardware structure of the mobile terminal of a method for testing radio frequency ablation according to an embodiment of the present invention. As shown in fig. 1, a mobile terminal may include one or more (only one is shown in fig. 1) processors 102 (the processor 102 may include, but is not limited to, a microprocessor MCU or a processing device such as a programmable logic device FPGA) and a memory 104 for storing data, wherein the mobile terminal may also include a transmission device 106 for communication functions and an input-output device 108. It will be appreciated by those skilled in the art that the structure shown in fig. 1 is merely illustrative and not limiting on the structure of the mobile terminal. For example, the mobile terminal may also include more or fewer components than shown in fig. 1, or have a different configuration than shown in fig. 1.

The memory 104 may be used to store computer programs, such as software programs of application software and modules, such as computer programs corresponding to the method for displaying device information in the embodiment of the present invention, and the processor 102 executes the computer programs stored in the memory 104 to perform various functional applications and data processing, i.e., implement the method. Memory 104 may include high-speed random access memory, and may also include non-volatile memory, such as one or more magnetic storage devices, flash memory, or other non-volatile solid-state memory. In some examples, the memory 104 may further include memory remotely located relative to the processor 102, which may be connected to the mobile terminal via a network. Examples of such networks include, but are not limited to, the internet, intranets, local area networks, mobile communication networks, and combinations thereof. The transmission device 106 is used to receive or transmit data via a network. Specific examples of the network may include a wireless network provided by a communication provider of the mobile terminal. In one example, the transmission device 106 includes a network adapter (Network Interface Controller, simply referred to as NIC) that can connect to other network devices through a base station to communicate with the internet. In one example, the transmission device 106 may be a Radio Frequency (RF) module, which is configured to communicate with the internet wirelessly.

In this embodiment, a method of testing radio frequency ablation operating on a mobile terminal, a computer terminal, or similar computing device is provided, it being noted that the steps illustrated in the flowchart of the figures may be performed in a computer system, such as a set of computer executable instructions, and that although a logical sequence is illustrated in the flowchart, in some cases the steps illustrated or described may be performed in a different order than that illustrated herein.

Fig. 2 is a flow chart of a method of testing radio frequency ablation according to an embodiment of the present application. As shown in fig. 2, the method comprises the steps of:

step S201, ablating a target object by adopting pulse voltage;

specifically, the target object may be organs such as a lung, a heart, or bionic organs such as a lung, a heart, or the like. The focus tissue contained in the target object is ablated by adopting the pulse voltage, so that the radio frequency current periodically acts on the focus tissue contained in the target object to generate heat, and the focus tissue contained in the target object is coagulated, denatured and necrotized, thereby achieving the effect of removing the focus tissue contained in the target object. The pulse voltage can be square wave pulse, and constant voltage ablation is kept; other types of pulses are also possible, such as triangular pulses, ladder-line pulses, etc.

Step S202, acquiring target impedance corresponding to the target object in an ablation process;

specifically, the target impedance is the impedance of the target object, and can be obtained through real-time detection in an ablation process. The impedance of the target object may include impedance of the lesion tissue contained in the detected target object or impedance of the surrounding tissue of the lesion contained in the detected target object, and of course, the impedance of the target object may be impedance obtained by comprehensively calculating impedance of the lesion tissue and impedance of the surrounding tissue of the lesion, or the like.

Step S203, controlling a perfusion device to perfuse the target object according to a preset perfusion mode under the condition that the target impedance is not greater than a first threshold value;

specifically, the first threshold is a preset limit value, and a specific value of the threshold can be flexibly set by a person skilled in the art according to actual situations. The preset perfusion mode may include a pulsed perfusion mode matched to a pulsed voltage. In practical applications, the perfusion apparatus may be any suitable perfusion apparatus, such as a perfusion pump, a perfusion machine, or the like. Specifically, the pouring device is used for pouring the cooling medium into the target object, and the target impedance corresponding to the target object is reduced by pouring the cooling medium into the target object.

Step S204, adjusting the preset perfusion mode when the target impedance is greater than the first threshold, so that the perfusion apparatus perfuses the target object according to the adjusted perfusion mode.

Specifically, when the target impedance is greater than the first threshold, it is indicated that the dehydration of the focal tissue contained in the target object is relatively serious, and in this case, the purpose of reducing the target impedance is achieved by adjusting the preset perfusion mode, so that a relatively sufficient thermal efficiency acts on the focal tissue contained in the target object in the subsequent ablation process.

Through the embodiment, firstly, a target object is ablated by adopting pulse voltage, and in the ablation process, the target impedance corresponding to the target object is obtained; controlling a perfusion device to perfuse the target object according to a preset perfusion mode under the condition that the target impedance is not greater than a first threshold value; and adjusting the preset pouring mode under the condition that the target impedance is larger than the first threshold value, and controlling the pouring equipment to pour the target object according to the adjusted pouring mode so as to adjust the target impedance. Compared with the problems of insufficient thermal efficacy and poor ablation effect caused by overlarge impedance and constant voltage of a target object in a constant-voltage ablation process in the prior art, the radio frequency ablation method provided by the application ablates the target object through pulse voltage and adopts a preset perfusion mode, when the target impedance in the ablation process is overlarge, the effect of adjusting the target impedance in the ablation process is achieved by adjusting the preset perfusion mode, so that the adjusted target impedance is not overlarge, the current passing through the focus tissue contained in the target object is ensured not to be overlarge and is overlarge due to overlarge target impedance, the thermal efficacy of the focus tissue contained in the target object in the ablation process is always stronger, and the ablation effect is ensured to be better.

In order to further avoid the problem that the target impedance is too large in the ablation process, so that the current passing through the focal tissue contained in the target object is too small, resulting in insufficient thermal efficiency and poor ablation effect, in an alternative scheme, when the target impedance is greater than the first threshold, the preset perfusion mode is adjusted, which includes: controlling the perfusion apparatus to be started and to continuously perfuse the cooling medium to the target object at a preset flow rate for a first preset time period under the condition that the target impedance is larger than the first threshold value; and under the condition that the target impedance is larger than the first threshold value after the first preset time period of pouring, acquiring the change rate of the target impedance, and adjusting the pouring flow rate of the pouring equipment according to the change rate and the current flow rate of the pouring equipment so as to reduce the target impedance corresponding to the target object. In the embodiment, when the target impedance is greater than a first threshold value, the perfusion equipment is controlled to perfuse the target object at a preset flow rate for a first preset time period to reduce the target impedance; when the target impedance corresponding to the perfused target object is still larger than the first threshold value, the reduction effect of the target impedance is not ideal, and under the condition, the perfusion flow rate at the moment is adjusted according to the change rate of the target impedance and the current flow rate of the perfusion equipment, so that the target impedance is further reduced, the target impedance can be adjusted to be not larger than the first threshold value as soon as possible, and the better ablation effect can be further ensured.

Specifically, the change rate is a parameter for representing the real-time increase condition of the target impedance in the ablation process, and specifically can be the change rate before the perfusion equipment is started, and the larger the change rate is, the faster the increase speed of the target impedance in the ablation process is. The cooling medium can be physiological saline, and the physiological saline is controlled to be infused into the target object in the constant voltage ablation process, so that the temperature of focus tissues contained in the target object can be reduced, the humidity of the focus tissues contained in the target object is increased, and the focus tissues contained in the target object are fundamentally prevented from crusting due to drying and heating; meanwhile, physiological saline can improve the conductivity and the heat conductivity of focus tissues contained in a target object, maintain the balance of impedance and keep the impedance in a relatively stable state. The voltage ablation and the normal saline infusion are combined, so that the target impedance can be stabilized within a certain range in the whole ablation process, the good ablation effect on focus tissues contained in a target object is ensured, meanwhile, the phenomenon that the focus tissues contained in the target object are scabbed is avoided, the scabbed tissues are adhered to an ablation instrument, and the problem that the target object is damaged when the ablation instrument is pulled out is also avoided.

A person skilled in the art may flexibly set the value of the first predetermined time period according to actual needs, for example, 300ms,400ms, etc., where in the embodiment of the present application, the first predetermined time period is 500ms.

In practical application, the method further comprises: setting an impedance early warning flag to 1 when the target impedance R is greater than the first threshold Ralarm, and setting an impedance early warning flag to 0 when the target impedance R is not greater than the first threshold Ralarm. So that the related personnel can know the size of the target impedance in time.

In another alternative embodiment, adjusting the perfusion flow rate of the perfusion apparatus according to the rate of change and the current flow rate of the perfusion apparatus includes: reducing the current flow rate of the perfusion apparatus to obtain a target flow rate when the rate of change is less than a second threshold; and under the condition that the change rate is not smaller than the second threshold value, increasing the current flow rate of the perfusion equipment to obtain the target flow rate. When the change rate is smaller than a second threshold value, the target impedance in the ablation process is slowly increased, the current flow rate of the perfusion equipment can be reduced, and the waste of cooling medium in the ablation process is avoided while the effect of reducing the target impedance is further realized; when the change rate is not smaller than the second threshold value, the target impedance in the ablation process is rapidly increased, and the current flow rate is required to be increased, so that the aim of rapidly reducing the target impedance is further fulfilled.

To further ensure that the target impedance falls back as soon as possible to not more than a first threshold, further increasing the current flow rate of the perfusion apparatus, if the rate of change is not less than the second threshold, to obtain the target flow rate, comprises: determining that the target flow rate is the sum of the current flow rate and a first preset value under the condition that the change rate is not smaller than the second threshold value Kstep and smaller than a third threshold value Kslow; determining that the target flow rate is the sum of the current flow rate and a second preset value under the condition that the change rate is not smaller than the third threshold Kslow and smaller than a fourth threshold Kmedium; determining that the target flow rate is the sum of the current flow rate and a third preset value under the condition that the change rate is not smaller than the fourth threshold Kmedium and smaller than a fifth threshold Kfast; and under the condition that the change rate is not smaller than the fifth threshold Kfast, determining that the target flow rate is the sum of the current flow rate and a fourth preset value, wherein the first preset value, the second preset value, the third preset value and the fourth preset value are sequentially increased, and the target flow rate is not larger than a flow rate threshold. By dividing four adjustment levels and pouring the target object according to the target flow rate corresponding to the adjustment level where the change rate is located, the target flow rate can be further ensured to be matched with the current target impedance change rate, and accordingly the value reduction effect of the target impedance after pouring is further ensured to be better.

Of course, the adjustment level of the change rate is not limited to the four levels, and may be, for example, 2 levels, 3 levels, or 6 levels, etc., and those skilled in the art may flexibly set the adjustment level according to actual needs. In a specific embodiment, the first preset value is 0.1ml/min, the second preset value is 0.2 ml/min, the third preset value is 0.3 ml/min, and the fourth preset value is 0.5 ml/min. Of course, the first preset value, the second preset value, the third preset value and the fourth preset value are not limited to the values, and may be flexibly set to other values according to actual situations.

In an exemplary embodiment, reducing the current flow rate of the perfusion apparatus to a target flow rate if the rate of change is less than a second threshold comprises: determining the target flow rate as a difference between the current flow rate and a fifth preset value when the current flow rate of the perfusion apparatus is greater than the predetermined flow rate; and determining that the target flow rate is the preset flow rate under the condition that the current flow rate is not larger than the preset flow rate. In the case where the current flow rate is greater than the predetermined flow rate, it is indicated that the current flow rate is greater, but that such a large flow rate is not required to perfuse the target object, so that the current flow rate is reduced by determining the target flow rate as the difference between the current flow rate and a fifth preset value; and under the condition that the current flow rate is not greater than the preset flow rate, directly taking the preset flow rate as the adjusted flow rate.

In a specific embodiment, the fifth preset value is 0.1ml/min. Of course, the fifth preset value is not limited to the above-mentioned value, and may be flexibly set by those skilled in the art according to actual situations.

In addition, in order to eliminate the influence caused by the excessive flow rate of the perfusion apparatus to the target object, in other embodiments of the present application, when the change rate is not less than the second threshold value, the current flow rate of the perfusion apparatus is increased, and after obtaining the target flow rate, the method further includes: determining whether the target flow rate is greater than a flow rate threshold Fmax, and determining that the target flow rate is the flow rate threshold if the target flow rate is greater than the flow rate threshold Fmax. And under the condition that the target flow rate obtained after the current flow rate is increased is greater than a preset flow rate threshold, the target object is perfused by taking the flow rate threshold as the target flow rate, so that the influence of the overlarge flow rate on the target object is further avoided, the situation that perfusion equipment is abnormal in perfusion can be avoided, and the flow rate threshold Fmax is the maximum perfusion flow rate of the perfusion equipment.

According to a further embodiment of the present application, controlling the perfusion apparatus to perfuse the target object according to a preset perfusion mode, where the target impedance is not greater than a first threshold value, includes: controlling the perfusion equipment to be started and perfusing the cooling medium to the target object at a preset flow rate under the condition that the target impedance is not greater than the first threshold value and the closing time of the perfusion equipment reaches a second preset time; and controlling the perfusion equipment to be closed under the condition that the perfusion time length reaches a fourth preset time length. In the ablation process, under the condition that the target impedance is not larger than a first threshold value, the current target impedance is not influenced by the ablation effect basically, at the moment, in order to avoid the influence of overlong ablation time on a patient under the condition of ensuring the ablation effect, the perfusion equipment is controlled to periodically perform the perfusion work at a preset flow rate, the controllability of the ablation time can be ensured as much as possible, and the influence of overlong ablation time on the patient with poor experience is avoided.

In order to further ensure that the periodic perfusion function of the perfusion apparatus is easier to control, under the condition that the perfusion apparatus is closed, a fourth timer Tp 'is controlled to start timing, and under the condition that the timing duration of the fourth timer Tp' reaches the second preset duration Tpi, the perfusion apparatus is controlled to be opened. Before the fourth timer is controlled to start timing, the fourth timer may be cleared. When the perfusion apparatus is started, a first timer Tp is controlled to start timing, and when the timing of the first timer Tp reaches a fourth preset time period Tpr, the perfusion apparatus is controlled to be closed. Before the first timer is controlled to start timing, the first timer can be cleared.

In a practical application, the pulse voltage may be any suitable voltage with variability and continuity, and according to an exemplary embodiment of the present application, the ablation of the target object with the pulse voltage includes: an output step of outputting a predetermined voltage to ablate the target object; stopping outputting the preset voltage under the condition that the ablation duration reaches a fifth preset duration, wherein the ablation duration is used for recording the duration of continuously outputting the preset voltage each time; a circulation step, in which the outputting step and the stopping step are sequentially executed at least once until the total ablation duration reaches a preset duration when the idle duration reaches a sixth preset duration, wherein the idle duration is used for recording the duration of stopping outputting the preset voltage each time, and the total ablation duration is the sum of all the ablation durations and all the idle durations; and determining, namely stopping the ablation action of the target object and determining that the ablation is ended under the condition that the total ablation duration reaches the preset duration. In the embodiment, when the square wave pulse voltage is adopted to ablate the target object, the infusion mode of the infusion device is adjusted, so that the overlarge target impedance corresponding to the target object is avoided, and the effect of radio frequency ablation is further improved.

Of course, the implementation of ablating the target object with the pulse voltage is not limited to the described manner, for example, ablating the target object with the pulse voltage may further include the following steps:

step S2011: outputting a preset voltage to ablate the target object;

specifically, the predetermined voltage is a preset voltage value, and a specific value of the predetermined voltage can be determined by a person skilled in the art according to experience or experiment.

Step S2012: stopping outputting the predetermined voltage when the ablation duration reaches a fifth predetermined duration or when the target impedance is not less than a sixth threshold;

specifically, the ablation duration is used for recording the duration of outputting the preset voltage continuously each time, and the fifth preset duration and the sixth threshold are preset values according to experience, experiments or other modes.

Step S2013: and re-outputting the preset voltage to ablate the target object when the idle time reaches a sixth preset time or the target impedance is not larger than a seventh threshold value, wherein the seventh threshold value is smaller than the sixth threshold value.

Specifically, the idle time length is used for recording the time length for stopping outputting the preset voltage each time, and determining to finish one ablation process under the condition that the sum of all the idle time lengths and all the ablation time lengths needs to reach the preset total ablation time length.

In the embodiment, in addition to stopping voltage output when the ablation duration reaches the fifth predetermined duration and continuing voltage output when the idle duration reaches the sixth predetermined duration, stopping voltage output or continuing voltage output control is performed according to the target impedance, specifically, when the target impedance is not smaller than the sixth threshold, it is indicated that the target impedance is larger at this time, and the current through the focal tissue contained in the target object is too small when the ablation preset voltage is unchanged, and the ablation thermal efficiency is insufficient at this time, and in this case, the effect of voltage output on the focal tissue contained in the target object is not large, so that outputting of the preset voltage is stopped at this time; when the target impedance is not greater than the seventh threshold, it is indicated that the target impedance is smaller at this time, and the voltage ablation can be continued, and the effect of performing the voltage ablation is better, so that the predetermined voltage is also output again at this time. Through the simultaneous regulation and control of pulse voltage and the perfusion mode of the perfusion equipment, the method can effectively avoid overlarge target impedance corresponding to a target object, promote the ablation effect, and provide double guarantee, and ensure the normal running of radio frequency ablation under the condition that any one of the regulation and control of pulse voltage and the perfusion mode of the perfusion equipment fails.

In the actual setting process, the seventh threshold is far smaller than the sixth threshold, the sixth threshold is a preset ablation stopping impedance threshold Rstop, and the seventh threshold is a preset ablation starting impedance Rstart.

The ablation duration and the idle duration can be realized by controlling the timing and stopping of a timer, and the specific process is as follows: controlling a second timer t to start timing while outputting a preset voltage to ablate the target object; when the second timer t reaches the second preset time Tr, indicating that the ablation time reaches a fifth preset time, stopping outputting the preset voltage at the moment, and controlling a third timer t' to start timing; and when the third timer t' reaches the third preset time Ti, the idle time reaches a sixth preset time. In order to ensure that the control process of radio frequency ablation is simpler and easier to realize, the control process is also used for controlling the second timer to be cleared before the second timer is controlled to start timing and is also used for controlling the third timer to be cleared before the third timer is controlled to start timing. In the practical application process, the second timer and the third timer may be the same timer or may be different timers.

According to another specific embodiment of the present application, in the case that the target impedance is not less than a sixth threshold, the method further includes setting an impedance anomaly flag to 1; and setting the impedance anomaly flag to 0 when the target impedance is not greater than a seventh threshold value.

In order to enable those skilled in the art to more clearly understand the technical solutions of the present application, the implementation procedure of the radio frequency ablation test method of the present application will be described in detail below with reference to specific embodiments.

The embodiment relates to a specific radio frequency ablation test method, wherein the voltage control flow of the radio frequency ablation method is shown in fig. 3, and the perfusion control flow of the radio frequency ablation method is shown in fig. 4. As shown in fig. 3, the constant voltage ablation adopts a voltage pulse mode to ablate, and the time of outputting the ablation voltage Tr is controlled at the beginning, then the voltage output is stopped, the stopping time is Ti, and the voltage pulse output is controlled. In the ablation process, the temperature of focus tissues contained in the target object is increased due to the thermal effect, the focus tissues contained in the target object are dehydrated, the impedance is increased, and if the target impedance is more than Rstop, the output of the ablation voltage is stopped. After the output of the ablation voltage is stopped, the impedance can fall back, and when the impedance value is less than or equal to Rstart, the output of the ablation voltage is recovered. The voltage control flow is as follows:

Step a) starts voltage output, and the second timer t is cleared.

Step b), the second timer t carries out timing processing, meanwhile, whether the ablation time is completed or not is judged, and if the ablation residual time=0, the ablation is finished. If the ablation remaining time is not equal to 0, the next operation is performed.

Step c) if

Target impedance->

Repeating the step b) when the step is performed; if the target impedance->

Stopping the voltage output, setting the impedance abnormality flag to 1, and executing the step e).

Step d) if t > =tr, stopping the voltage output, and resetting the third timer t' to zero, and executing the next step.

Step e) ending the ablation if the ablation time remaining = 0. If the ablation remaining time is not equal to 0, the next operation is performed.

Step f) if the impedance anomaly flag=1, determining in real time whether the target impedance R is smaller than Rstart. If R is less than or equal to Rstart, the impedance anomaly flag is set to 0, and the step a is executed. If R > Rstart, step e) is performed.

Step g) if the impedance anomaly flag=0, the third timer t' performs a timer process.

Step h) ending the ablation if the ablation remaining time = 0. If the ablation remaining time is not equal to 0, the next operation is performed.

Step i) if

ExecuteStep g).

Step j) if

Step a) is performed.

As shown in fig. 4, in the constant voltage ablation process, the initial control of the perfusion pump uses a pulse perfusion mode, after the ablation start device controls the perfusion pump to idle Tpi time, the perfusion is performed by using the flow rate Fm, and the perfusion enters an idle state after Tpr time. In the ablation process, the temperature of focus tissues contained in a target object is increased due to a thermal effect, the focus tissues contained in the target object are dehydrated, the impedance is increased, if the target impedance is larger than Ralarm, a perfusion pump is controlled to perform continuous perfusion, and the flow rate is controlled according to the change rate of the target impedance corresponding to the target object. The specific control flow is as follows:

step 1), the perfusion pump is in an idle state, and the fourth timer Tp' is controlled to be cleared;

step 2) controlling a fourth timer Tp' to perform timing processing, and executing the next step;

step 3) if the target object resistance R is more than Ralarm, executing step 8);

step 4) if the target object resistance R is less than or equal to Ralarm, when the fourth timer Tp' < Tpi and the ablation is not finished, executing step 2), and if the ablation is finished, ending the control flow of the perfusion pump; when the fourth timer Tp' is more than or equal to Tpi, controlling the perfusion pump to start perfusion, wherein the perfusion flow rate F=Fm, starting timing when the first timer Tp is cleared, and executing the next step.

Step 5), the first timer Tp carries out timing processing, and the next step is executed;

step 6) if the target object resistance R > Ralarm, executing step 8);

step 7) if R is less than or equal to Ralarm, judging that the first timer Tp is more than or equal to Tpr when ablation is not finished, and executing the step 1); when the first timer Tp is less than Tpr, executing the step 5); and if the ablation is finished, ending the perfusion treatment and ending the current flow judgment.

Step 8) under the condition that R is larger than Ralarm, setting an impedance early warning mark as 1, and pouring by using the flow rate of F=Fm;

step 9) judging whether the ablation is finished in real time, if not, executing the next step after continuously pouring for a set period of time by using the flow rate of F=Fm; and if the ablation is finished, ending the perfusion treatment and ending the current flow judgment.

Step 10), if R is less than or equal to Ralarm, setting an impedance early warning mark to 0, and executing the step 1); if the target object resistance R > Ralarm, the next step is performed.

Step 11) after continuous perfusion for 500ms, and under the condition that R is greater than Ralarm, calculating the change rate K= (Ri-Ri-1)/T of target impedance, wherein Ri is current sampling impedance, ri-1 is last sampling impedance, and T is the sampling interval time of the two impedances. If K < Ksteadily, go to step 12), otherwise go to step 13).

Step 12) if the flow rate F > Fm, reducing the flow rate of the infusion pump by 0.1ml per minute to obtain a reduced flow rate, namely F=F-0.1 ml/min, continuously infusing the set duration by the infusion pump according to the reduced flow rate F, and re-judging the change rate of the target impedance under the condition that ablation is not finished; if the flow rate F is less than or equal to Fm, the infusion pump directly infuses for a set time according to the flow rate F, and the change rate of the target impedance is judged again under the condition that ablation is not finished;

step 13) if Ksteadily is less than or equal to K < Kslow, the flow rate of the infusion pump is increased by 0.1ml per minute, resulting in an increased flow rate, i.e., f=f+0.1 ml/min, and step 17) is performed.

Step 14) if

The flow rate of the infusion pump is increased by 0.2ml per minute, resulting in an increased flow rate, i.e. f=f+0.2 ml/min, step 17 is performed.

Step 15) if

The flow rate of the infusion pump is increased by 0.3ml per minute, resulting in an increased flow rate, i.e. f=f+0.3 ml/min, step 17 is performed.

Step 16) if

The flow rate of the infusion pump is increased by 0.4ml per minute, resulting in an increased flow rate, i.e. f=f+0.4ml/min, step 17 is performed.

Step 17) if the calculated latest flow rate

And determining the flow rate of the perfusion pump as Fmax, obtaining the determined flow rate, namely F=fmax, continuously perfusing the perfusion pump for a set time period according to the adjusted flow rate F, and re-judging the change rate of the target impedance under the condition that ablation is not finished.

The model of voltage ablation by adopting the existing radio frequency ablation test method is shown in fig. 5, the model of voltage ablation by adopting the radio frequency ablation test method is shown in fig. 6, and comparison of fig. 5 and fig. 6 shows that the radio frequency ablation test method can control the target impedance in the ablation process within a preset range, so that a good ablation effect is ensured.

It should be noted that the steps illustrated in the flowcharts of the figures may be performed in a computer system such as a set of computer executable instructions, and that although a logical order is illustrated in the flowcharts, in some cases the steps illustrated or described may be performed in an order other than that illustrated herein.

The embodiment of the application also provides a testing device for radio frequency ablation, and it is noted that the testing device for radio frequency ablation of the embodiment of the application can be used for executing the testing method for radio frequency ablation provided by the embodiment of the application. The device is used for implementing the embodiments and the preferred embodiments, and is not described again. As used below, the term "module" may be a combination of software and/or hardware that implements a predetermined function. While the means described in the following embodiments are preferably implemented in software, implementation in hardware, or a combination of software and hardware, is also possible and contemplated.

The following describes a radio frequency ablation testing device provided in an embodiment of the present application.

Fig. 7 is a schematic diagram of a testing device for radio frequency ablation according to an embodiment of the present application. As shown in fig. 7, the apparatus includes:

an ablation unit 10 for ablating a target object with a pulse voltage;

An acquiring unit 20, configured to acquire a target impedance corresponding to the target object during an ablation process;

A control unit 30, configured to control a perfusion apparatus to perfuse the target object according to a preset perfusion mode, if the target impedance is not greater than a first threshold;

And an adjusting unit 40, configured to adjust the preset perfusion mode when the target impedance is greater than the first threshold, so that the perfusion apparatus perfuses the target object according to the adjusted perfusion mode.

In the embodiment, an ablation unit is used for ablating a target object by adopting pulse voltage, and in the ablation process, a target impedance corresponding to the target object is obtained by an obtaining unit; under the condition that the target impedance is not greater than a first threshold value, pouring the target object in a preset pouring mode through a control unit pouring device; and under the condition that the target impedance is larger than the first threshold value, adjusting the preset pouring mode, and controlling the pouring equipment to pour the target object according to the adjusted pouring mode so as to adjust the target impedance. Compared with the constant voltage ablation process of the prior art, the impedance of the target object is overlarge and the voltage is constant, so that the current passing through focus tissues contained in the target object is overlarge, the problem of insufficient thermal efficiency and poor ablation effect is solved, the radio frequency ablation device of the application ablates the target object through pulse voltage and adopts a preset perfusion mode to perfuse the target object, when the target impedance in the ablation process is overlarge, the effect of adjusting the target impedance in the ablation process is achieved by adjusting the preset perfusion mode, the adjusted target impedance is not overlarge, the current passing through focus tissues contained in the target object is not overlarge and is small due to the overlarge target impedance, the thermal efficiency of the focus tissues contained in the target object in the ablation process is always stronger, and the good ablation effect is ensured.

In order to further avoid the problem that the target impedance is too high during the ablation process, so that the current passing through the focal tissue contained in the target object is too low, resulting in insufficient thermal efficacy and poor ablation effect, in an alternative scheme, the adjusting unit comprises: a first control module for controlling the perfusion apparatus to be turned on and to continue to perfuse the cooling medium to the target object at a predetermined flow rate for a first predetermined period of time if the target impedance is greater than the first threshold; and the acquisition module is used for acquiring the change rate of the target impedance under the condition that the target impedance is larger than the first threshold value after the first preset time period passes, and adjusting the perfusion flow rate of the perfusion equipment according to the change rate and the current flow rate of the perfusion equipment so as to reduce the target impedance corresponding to the target object. In the embodiment, when the target impedance is greater than a first threshold value, the perfusion equipment is controlled to perfuse the target object at a preset flow rate for a first preset time period to reduce the target impedance; when the target impedance corresponding to the perfused target object is still larger than the first threshold value, the reduction effect of the target impedance is not ideal, and under the condition, the perfusion flow rate at the moment is adjusted according to the change rate of the target impedance and the current flow rate of the perfusion equipment, so that the target impedance is further reduced, the target impedance can be adjusted to be not larger than the first threshold value as soon as possible, and the better ablation effect can be further ensured.

In practical application, the device further comprises: the first setting unit is configured to set an impedance early warning flag to 1 if the target impedance R is greater than the first threshold Ralarm, and set an impedance early warning flag to 0 if the target impedance R is not greater than the first threshold Ralarm. So that the related personnel can know the size of the target impedance in time.

In another alternative embodiment, the acquiring module includes: a reducing submodule, configured to reduce a current flow rate of the perfusion apparatus to obtain a target flow rate if the rate of change is less than a second threshold; and the increasing submodule is used for increasing the current flow rate of the perfusion equipment to obtain the target flow rate under the condition that the change rate is not smaller than the second threshold value. When the change rate is smaller than a second threshold value, the target impedance in the ablation process is slowly increased, the current flow rate of the perfusion equipment can be reduced, and the waste of cooling medium in the ablation process is avoided while the effect of reducing the target impedance is further realized; when the change rate is not smaller than the second threshold value, the target impedance in the ablation process is rapidly increased, and the current flow rate is required to be increased, so that the aim of rapidly reducing the target impedance is further fulfilled.

In order to further ensure that the target impedance can fall back to not more than the first threshold value as soon as possible, the increasing sub-module is further configured to determine that the target flow rate is the sum of the current flow rate and a first preset value when the rate of change is not less than the second threshold value ksteaddity and less than a third threshold value Kslow; the increasing sub-module is further configured to determine that the target flow rate is a sum of the current flow rate and a second preset value when the rate of change is not less than the third threshold Kslow and less than a fourth threshold Kmedium; the increasing sub-module is further configured to determine that the target flow rate is a sum of the current flow rate and a third preset value when the rate of change is not less than the fourth threshold Kmedium and less than a fifth threshold Kfast; the increasing sub-module is further configured to determine, when the rate of change is not less than the fifth threshold Kfast, that the target flow rate is a sum of the current flow rate and a fourth preset value, where the first preset value, the second preset value, the third preset value, and the fourth preset value are sequentially increased, and the target flow rate is not greater than a flow rate threshold. By dividing four adjustment levels and pouring the target object according to the target flow rate corresponding to the adjustment level where the change rate is located, the target flow rate can be further ensured to be matched with the current target impedance change rate, and accordingly the value reduction effect of the target impedance after pouring is further ensured to be better.

In an exemplary embodiment, the reducing sub-module is further configured to determine the target flow rate as a difference between the current flow rate and a fifth preset value, in a case where the current flow rate of the perfusion apparatus is greater than the predetermined flow rate; the reduction sub-module is further configured to determine that the target flow rate is the predetermined flow rate if the current flow rate is not greater than the predetermined flow rate. In the case where the current flow rate is greater than the predetermined flow rate, it is indicated that the current flow rate is greater, but that such a large flow rate is not required to perfuse the target object, so that the current flow rate is reduced by determining the target flow rate as the difference between the current flow rate and a fifth preset value; and under the condition that the current flow rate is not greater than the preset flow rate, directly taking the preset flow rate as the adjusted flow rate.

In addition, in order to eliminate the influence of the excessive flow rate of the perfusion apparatus on the target object, in other embodiments of the present application, the apparatus further includes: and the determining unit is used for increasing the current flow rate of the perfusion equipment under the condition that the change rate is not smaller than the second threshold value, determining whether the target flow rate is larger than a flow rate threshold value Fmax or not after obtaining the target flow rate, and determining that the target flow rate is the flow rate threshold value Fmax under the condition that the target flow rate is larger than the flow rate threshold value Fmax. And under the condition that the target flow rate obtained after the current flow rate is increased is greater than a preset flow rate threshold, the target object is perfused by taking the flow rate threshold as the target flow rate, so that the influence of the overlarge flow rate on the target object is further avoided, the situation that perfusion equipment is abnormal in perfusion can be avoided, and the flow rate threshold Fmax is the maximum perfusion flow rate of the perfusion equipment.

According to a further embodiment of the present application, the control unit comprises: the second control module is used for controlling the starting of the pouring equipment and pouring the cooling medium to the target object at a preset flow rate under the condition that the target impedance is not greater than the first threshold value and the closing time of the pouring equipment reaches a second preset time; and the third control module is used for controlling the perfusion equipment to be closed under the condition that the perfusion time length reaches a fourth preset time length. In the ablation process, under the condition that the target impedance is not larger than a first threshold value, the current target impedance is not influenced by the ablation effect basically, at the moment, in order to avoid the influence of overlong ablation time on a patient under the condition of ensuring the ablation effect, the perfusion equipment is controlled to periodically perform the perfusion work at a preset flow rate, the controllability of the ablation time can be ensured as much as possible, and the influence of overlong ablation time on the patient with poor experience is avoided.

In order to further ensure that the periodic perfusion function of the perfusion apparatus is easier to control, under the condition that the perfusion apparatus is closed, a fourth timer Tp' is controlled to start timing, and under the condition that the timing duration of the fourth timer Tp reaches the second preset duration Tpi, the perfusion apparatus is controlled to be opened. Before the fourth timer is controlled to start timing, the fourth timer may be cleared. When the perfusion apparatus is started, a first timer Tp is controlled to start timing, and when the timing of the first timer Tp reaches a fourth preset time period Tpr, the perfusion apparatus is controlled to be closed. Before the first timer is controlled to start timing, the first timer can be cleared.

In a practical application, the pulsed voltage may be any suitable voltage with variability and continuity, according to an exemplary embodiment of the present application, the ablation unit comprises: the first output module is used for outputting a preset voltage to ablate the target object; the first stopping module is used for stopping outputting the preset voltage when the ablation duration reaches a fifth preset duration, and the ablation duration is used for recording the duration of continuously outputting the preset voltage each time; the circulation module is used for performing the output step and the stopping step at least once in sequence under the condition that the idle time length reaches a sixth preset time length, wherein the idle time length is used for recording the time length of stopping outputting the preset voltage each time, and the total ablation time length is the sum of all the ablation time lengths and all the idle time lengths; the determining module is used for determining that the ablation action of the target object is stopped and the ablation is ended under the condition that the total ablation duration reaches the preset duration. In the embodiment, when the square wave pulse voltage is adopted to ablate the target object, the infusion mode of the infusion device is adjusted, so that the overlarge target impedance corresponding to the target object is avoided, and the effect of radio frequency ablation is further improved.

Of course, the implementation of ablating the target object with the pulse voltage is not limited to the described manner, for example, the ablating unit may further include:

the second output module is used for outputting a preset voltage to ablate the target object;

A second stopping module for stopping outputting the predetermined voltage when the ablation duration reaches a fifth predetermined duration or when the target impedance is not less than a sixth threshold;

And the third output module is used for outputting the preset voltage again to ablate the target object when the idle time reaches a sixth preset time or the target impedance is not larger than a seventh threshold value, and the seventh threshold value is smaller than the sixth threshold value.

The radio frequency ablation testing device comprises a processor and a memory, wherein the ablation unit, the acquisition unit, the control unit, the adjustment unit and the like are stored in the memory as program units, and the processor executes the program units stored in the memory to realize corresponding functions. The modules are all located in the same processor; alternatively, the modules may be located in different processors in any combination.

The processor includes a kernel, and the kernel fetches the corresponding program unit from the memory. The kernel can be provided with one or more than one kernel, and the problem of poor ablation effect of the constant pressure ablation method in the prior art is solved by adjusting kernel parameters.

The memory may include volatile memory, random Access Memory (RAM), and/or nonvolatile memory, such as Read Only Memory (ROM) or flash memory (flash RAM), among other forms in computer readable media, the memory including at least one memory chip.

The embodiment of the invention provides a computer readable storage medium, which comprises a stored program, wherein when the program runs, a device where the computer readable storage medium is located is controlled to execute the radio frequency ablation test method.

Specifically, the method for testing radio frequency ablation comprises the following steps:

step S201, ablating a target object by adopting pulse voltage;

The embodiment of the invention provides a processor which is used for running a program, wherein the program runs to execute the radio frequency ablation testing method.

step S201, ablating a target object by adopting pulse voltage;

The embodiment of the invention provides a test system for radio frequency ablation, which comprises the following components: a radio frequency ablation device; a controller of the radio frequency ablation device comprising one or more processors, a memory and one or more programs, wherein the one or more programs are stored in the memory and configured to be executed by the one or more processors, which when executing the programs implement at least the following steps:

step S201, ablating a target object by adopting pulse voltage;

The controller herein may be a server, PC, PAD, cell phone, etc.

The present application also provides a computer program product adapted to perform a program initialized with at least the following method steps when executed on a data processing device:

step S201, ablating a target object by adopting pulse voltage;

It will be appreciated by those skilled in the art that the modules or steps of the invention described may be implemented in a general purpose computing device, they may be concentrated on a single computing device, or distributed across a network of computing devices, they may be implemented in program code that is executable by computing devices, so that they may be stored in a memory device for execution by computing devices, and in some cases, the steps shown or described may be performed in a different order than that shown or described, or they may be separately fabricated into individual integrated circuit modules, or multiple modules or steps of them may be fabricated into a single integrated circuit module. Thus, the present invention is not limited to any specific combination of hardware and software.

It will be appreciated by those skilled in the art that embodiments of the present application may be provided as a method, system, or computer program product. Accordingly, the present application may take the form of an entirely hardware embodiment, an entirely software embodiment, or an embodiment combining software and hardware aspects. Furthermore, the present application may take the form of a computer program product embodied on one or more computer-usable storage media (including, but not limited to, disk storage, CD-ROM, optical storage, and the like) having computer-usable program code embodied therein.

The present application is described with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems) and computer program products according to embodiments of the application. It will be understood that each flow and/or block of the flowchart illustrations and/or block diagrams, and combinations of flows and/or blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to a processor of a general purpose computer, special purpose computer, embedded processor, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.

These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including instruction means which implement the function specified in the flowchart flow or flows and/or block diagram block or blocks.

These computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.

In one typical configuration, a computing device includes one or more processors (CPUs), input/output interfaces, network interfaces, and memory.

The memory may include volatile memory in a computer-readable medium, random Access Memory (RAM) and/or nonvolatile memory, etc., such as Read Only Memory (ROM) or flash RAM. Memory is an example of a computer-readable medium.

Computer readable media, including both non-transitory and non-transitory, removable and non-removable media, may implement information storage by any method or technology. The information may be computer readable instructions, data structures, modules of a program, or other data. Examples of storage media for a computer include, but are not limited to, phase change memory (PRAM), static Random Access Memory (SRAM), dynamic Random Access Memory (DRAM), other types of Random Access Memory (RAM), read Only Memory (ROM), electrically Erasable Programmable Read Only Memory (EEPROM), flash memory or other memory technology, compact disc read only memory (CD-ROM), digital Versatile Discs (DVD) or other optical storage, magnetic cassettes, magnetic tape magnetic disk storage or other magnetic storage devices, or any other non-transmission medium, which can be used to store information that can be accessed by a computing device. Computer-readable media, as defined herein, does not include transitory computer-readable media (transmission media), such as modulated data signals and carrier waves.

It should also be noted that the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article or apparatus that comprises an element.

From the above description, it can be seen that the embodiments described herein achieve the following technical effects:

1) According to the radio frequency ablation testing method, firstly, a target object is ablated by adopting pulse voltage, and in the ablation process, target impedance corresponding to the target object is obtained; controlling a perfusion device to perfuse the target object according to a preset perfusion mode under the condition that the target impedance is not greater than a first threshold value; and adjusting the preset pouring mode under the condition that the target impedance is larger than the first threshold value, and controlling the pouring equipment to pour the target object according to the adjusted pouring mode so as to adjust the target impedance. Compared with the problems of insufficient thermal efficacy and poor ablation effect caused by overlarge impedance and constant voltage of a target object in a constant-voltage ablation process in the prior art, the radio frequency ablation method provided by the application ablates the target object through pulse voltage and adopts a preset perfusion mode, when the target impedance in the ablation process is overlarge, the effect of adjusting the target impedance in the ablation process is achieved by adjusting the preset perfusion mode, so that the adjusted target impedance is not overlarge, the current passing through the focus tissue contained in the target object is ensured not to be overlarge and is overlarge due to overlarge target impedance, the thermal efficacy of the focus tissue contained in the target object in the ablation process is always stronger, and the ablation effect is ensured to be better. ,

2) According to the radio frequency ablation testing device, the target object is ablated by the ablation unit through the pulse voltage, and in the ablation process, the target impedance corresponding to the target object is obtained through the obtaining unit; under the condition that the target impedance is not greater than a first threshold value, pouring the target object in a preset pouring mode through a control unit pouring device; and under the condition that the target impedance is larger than the first threshold value, adjusting the preset pouring mode, and controlling the pouring equipment to pour the target object according to the adjusted pouring mode so as to adjust the target impedance. Compared with the constant voltage ablation process of the prior art, the impedance of the target object is overlarge and the voltage is constant, so that the current passing through focus tissues contained in the target object is overlarge, the problem of insufficient thermal efficiency and poor ablation effect is solved, the radio frequency ablation device of the application ablates the target object through pulse voltage and adopts a preset perfusion mode to perfuse the target object, when the target impedance in the ablation process is overlarge, the effect of adjusting the target impedance in the ablation process is achieved by adjusting the preset perfusion mode, the adjusted target impedance is not overlarge, the current passing through focus tissues contained in the target object is not overlarge and is small due to the overlarge target impedance, the thermal efficiency of the focus tissues contained in the target object in the ablation process is always stronger, and the good ablation effect is ensured.

The foregoing description is only of the preferred embodiments of the present application and is not intended to limit the same, but rather, various modifications and variations may be made by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims

1. A method of testing radio frequency ablation comprising:

ablating the target object by adopting pulse voltage;

in the ablation process, acquiring target impedance corresponding to the target object;

controlling a perfusion device to perfuse the target object according to a preset perfusion mode under the condition that the target impedance is not greater than a first threshold value;

adjusting the preset perfusion mode under the condition that the target impedance is larger than the first threshold value, so that the perfusion equipment perfuses the target object according to the adjusted perfusion mode,

and adjusting the preset perfusion mode under the condition that the target impedance is greater than the first threshold value, wherein the method comprises the following steps:

controlling the perfusion apparatus to be started and to continuously perfuse the cooling medium to the target object at a preset flow rate for a first preset time period under the condition that the target impedance is larger than the first threshold value;

Under the condition that the target impedance is larger than the first threshold value after the first preset time period of pouring, acquiring the change rate of the target impedance, adjusting the pouring flow rate of the pouring equipment according to the change rate and the current flow rate of the pouring equipment so as to reduce the target impedance corresponding to the target object,

adjusting the perfusion flow rate of the perfusion apparatus according to the rate of change and the current flow rate of the perfusion apparatus, comprising:

reducing the current flow rate of the perfusion apparatus to obtain a target flow rate when the rate of change is less than a second threshold;

increasing the current flow rate of the perfusion apparatus to obtain the target flow rate if the rate of change is not less than the second threshold,

and increasing the current flow rate of the perfusion apparatus to obtain the target flow rate under the condition that the change rate is not smaller than the second threshold value, wherein the method comprises the following steps:

determining that the target flow rate is the sum of the current flow rate and a first preset value under the condition that the change rate is not smaller than the second threshold value and smaller than a third threshold value;

determining that the target flow rate is the sum of the current flow rate and a second preset value under the condition that the change rate is not smaller than the third threshold value and smaller than a fourth threshold value;

Determining that the target flow rate is the sum of the current flow rate and a third preset value under the condition that the change rate is not smaller than the fourth threshold value and smaller than a fifth threshold value;

and under the condition that the change rate is not smaller than the fifth threshold value, determining that the target flow rate is the sum of the current flow rate and a fourth preset value, wherein the first preset value, the second preset value, the third preset value and the fourth preset value are sequentially increased, and the target flow rate is not larger than the flow rate threshold value.

2. The method of claim 1, wherein reducing the current flow rate of the perfusion apparatus to a target flow rate if the rate of change is less than a second threshold comprises:

determining the target flow rate as a difference between the current flow rate and a fifth preset value when the current flow rate of the perfusion apparatus is greater than the predetermined flow rate;

and determining that the target flow rate is the preset flow rate under the condition that the current flow rate is not larger than the preset flow rate.

3. The method according to claim 1 or 2, wherein controlling the perfusion apparatus to perfuse the target object in a preset perfusion manner if the target impedance is not greater than a first threshold value, comprises:

Controlling the perfusion equipment to be started and perfusing the cooling medium to the target object at a preset flow rate under the condition that the target impedance is not greater than the first threshold value and the closing time of the perfusion equipment reaches a second preset time;

and controlling the perfusion equipment to be closed under the condition that the perfusion time length reaches a fourth preset time length.

4. The method of claim 1 or 2, wherein ablating the target object with the pulsed voltage comprises:

outputting a preset voltage to ablate the target object;

stopping outputting the predetermined voltage when the ablation duration reaches a fifth predetermined duration or when the target impedance is not less than a sixth threshold;

and re-outputting the preset voltage to ablate the target object under the condition that the idle time length reaches a sixth preset time length or the target impedance is not larger than a seventh threshold value, wherein the seventh threshold value is smaller than the sixth threshold value, the ablation time length is used for recording the time length of continuously outputting the preset voltage each time, and the idle time length is used for recording the time length of stopping outputting the preset voltage each time.

5. A test device for radio frequency ablation, comprising:

The ablation unit is used for ablating the target object by adopting pulse voltage;

the acquisition unit is used for acquiring target impedance corresponding to the target object in an ablation process;

the control unit is used for controlling the perfusion equipment to perfuse the target object according to a preset perfusion mode under the condition that the target impedance is not greater than a first threshold value;

an adjusting unit for adjusting the preset perfusion mode under the condition that the target impedance is larger than the first threshold value, so that the perfusion equipment perfuses the target object according to the adjusted perfusion mode,

the adjusting unit includes: a first control module for controlling the perfusion apparatus to be turned on and to continue to perfuse the cooling medium to the target object at a predetermined flow rate for a first predetermined period of time if the target impedance is greater than the first threshold; an acquisition module, configured to acquire a rate of change of the target impedance when the target impedance is greater than the first threshold value and adjust a perfusion flow rate of the perfusion apparatus according to the rate of change and a current flow rate of the perfusion apparatus so that the target impedance corresponding to the target object is reduced,

The acquisition module comprises: a reducing submodule, configured to reduce a current flow rate of the perfusion apparatus to obtain a target flow rate if the rate of change is less than a second threshold; an increasing sub-module for increasing the current flow rate of the perfusion apparatus to obtain the target flow rate if the rate of change is not less than the second threshold,

the increasing sub-module is further configured to determine that the target flow rate is a sum of the current flow rate and a first preset value when the rate of change is not less than the second threshold and less than a third threshold; the increasing sub-module is further configured to determine that the target flow rate is a sum of the current flow rate and a second preset value when the rate of change is not less than the third threshold and less than a fourth threshold; the increasing sub-module is further configured to determine that the target flow rate is a sum of the current flow rate and a third preset value when the rate of change is not less than the fourth threshold and less than a fifth threshold; the increasing sub-module is further configured to determine, when the rate of change is not less than the fifth threshold, that the target flow rate is a sum of the current flow rate and a fourth preset value, where the first preset value, the second preset value, the third preset value, and the fourth preset value are sequentially increased, and the target flow rate is not greater than the flow rate threshold.

6. A computer readable storage medium, characterized in that the computer readable storage medium comprises a stored program, wherein the program performs the method of any one of claims 1 to 4.

7. A processor for running a program, wherein the program when run performs the method of any one of claims 1 to 4.

8. A system for testing radio frequency ablation, comprising:

a radio frequency ablation device;

a controller of the radio frequency ablation device comprising one or more processors, a memory, and one or more programs, wherein the one or more programs are stored in the memory and configured to be executed by the one or more processors, the one or more programs comprising instructions for performing the method of any of claims 1-4.