CN116059301B

CN116059301B - Tea drink for preventing influenza and preparation method thereof

Info

Publication number: CN116059301B
Application number: CN202211527221.5A
Authority: CN
Inventors: 黄天赐; 吴卫刚; 范荫荫; 杨群; 吴洪飞; 骆维; 施枝江
Original assignee: Jiuzhou Tianrun Traditional Chinese Medicine Industry Co ltd
Current assignee: Jiuzhou Tianrun Traditional Chinese Medicine Industry Co ltd
Priority date: 2022-12-01
Filing date: 2022-12-01
Publication date: 2024-02-13
Anticipated expiration: 2042-12-01
Also published as: CN116059301A

Abstract

The invention discloses tea drink for preventing influenza and a preparation method thereof, and belongs to the technical field of tea drinks. The material is prepared from the following raw materials in parts by weight: 1-3 parts of honeysuckle, 1-4 parts of weeping forsythiae capsule, 1-2 parts of radix isatidis, 2-3 parts of reed rhizome, 2-3 parts of cogongrass rhizome, 2-4 parts of wrinkled gianthyssop herb, 2-5 parts of radix angelicae and 1 part of tsaoko amomum fruit. The preparation method comprises the following steps: mixing radix Isatidis, rhizoma Phragmitis and lalang grass rhizome at a certain proportion, pulverizing into coarse powder, decocting with 3-6 times of water for 30-45min, decocting for 2-4 times, and mixing decoctions; mixing flos Lonicerae, fructus forsythiae, herba Agastaches, radix Angelicae Dahuricae and fructus Tsaoko at a certain ratio, and pulverizing to obtain fine powder; mixing the decoction with the fine powder according to the proportion, adding 1-4 times of water by volume of the mixed solution, stirring uniformly, and concentrating in vacuum at 40-60 ℃; freeze-drying the concentrated solution, and preparing the dried sample into granular tea drink; ozone is adopted for sterilization treatment; quantitatively packaging to obtain the product.

Description

Tea drink for preventing influenza and preparation method thereof

Technical Field

The invention relates to the technical field of tea drinks, in particular to tea drink for preventing influenza and a preparation method thereof.

Background

Influenza is an acute respiratory infection caused by influenza virus, is a disease with strong infectivity and high transmission speed, can show symptoms such as high fever, purulent phlegm, severe cough and/or dyspnea, and can also show heart failure, shock and the like when serious. In view of the limitations of the current human medical level, conventional treatments are mostly injection of antiviral drugs or prevention of influenza.

Vaccination is the most economical and effective method of preventing influenza, but one vaccination with influenza does not represent a "life-long benefit", and because of the wide variety of viruses and the potential for variation, influenza vaccines are injected once a year. The efficacy of influenza vaccines lasts approximately one year, and over the last year vaccination is still needed to achieve protection. And after the influenza vaccine is injected, antibodies can be produced after half a month, so that the aim of prevention is achieved, and the influenza virus cannot be resisted before the antibodies are produced. In addition, patients with ovalbumin allergy, acute exacerbation and fever of acute disease, severe chronic disease, uncontrolled epilepsy and other progressive neurological diseases, and those with a history of Ji Lanba Rayleigh syndrome, etc. cannot be vaccinated with influenza vaccines. From the foregoing, it can be seen that there are also major limitations to vaccination against influenza.

At present, in the antiviral drugs on the market, the direct treatment effect on the viral influenza is less, and most influenza is cured by the immunity of the human body; moreover, long-term administration of antiviral drugs causes resistance to viruses, further reducing the therapeutic effect and even adversely affecting the human body itself. Meanwhile, in order to reduce the occurrence of antiviral drug resistant strains, the prevention by using antiviral drugs in a large range or conventionally is not recommended.

Along with the pursuit of healthy life style, disease prevention by disease treatment has become a popular treatment mode for people. In China, chinese herbal medicine is rich in resources, has increasingly obvious effect on prevention and treatment of serious diseases as a traditional Chinese medicine for 5000 years, is milder in medicine property and can treat the root cause compared with western medicines, so that development of a tea drink with influenza prevention effect is significant for people with poor resistance or cold initial stage.

Disclosure of Invention

The tea drink for preventing influenza provided by the invention can be used for a long time, can effectively improve body functions, strengthen immunity, effectively prevent influenza and is suitable for general people; in addition, the invention also provides a preparation method of the tea beverage, which adopts a corresponding treatment method aiming at different raw materials, keeps special faint scent on the basis of guaranteeing the extraction of active ingredients, has fresh and sweet taste, can increase the drinking willingness, and is suitable for long-term drinking. The technical scheme provided by the invention is as follows:

on one hand, the invention provides a tea drink for preventing influenza, which is prepared from the following raw materials in parts by weight: 1-3 parts of honeysuckle, 1-4 parts of weeping forsythiae capsule, 1-2 parts of radix isatidis, 2-3 parts of reed rhizome, 2-3 parts of cogongrass rhizome, 2-4 parts of wrinkled gianthyssop herb, 2-5 parts of radix angelicae and 1 part of tsaoko amomum fruit. Decocting radix Isatidis, rhizoma Phragmitis and lalang grass rhizome to obtain decoction, mixing the decoction with the medicinal powder, vacuum concentrating at low temperature, lyophilizing, pulverizing, and shaping to obtain granule tea beverage. Specifically, the radix isatidis, the reed rhizome and the cogongrass rhizome have more water-soluble components, and most of the effective components can be obtained by decoction. The honeysuckle, the weeping forsythia, the wrinkled gianthyssop herb, the dahurian angelica root and the tsaoko amomum fruit have volatile components, and are decomposed after being heated, so that the loss of active ingredients is more, and the decoction is not performed. More effective component substances in the medicinal materials can be extracted through decoction and powdering treatment. The tea beverage in the form of granule is prepared by low-temperature vacuum concentration and freeze-drying, so that the decomposition of active ingredients and the decomposition or change of faint scent ingredients are avoided.

The following description of the components is provided:

honeysuckle flower, sweet and cold. Enter lung, heart and stomach meridians; clearing heat and detoxicating, dispelling wind and heat; can be used for treating carbuncle, furuncle, pharyngitis, erysipelas, dysentery with blood, wind-heat type common cold, and epidemic febrile disease. The modern pharmacological research shows that honeysuckle has a certain inhibition effect on various bacteria, is a typical broad-spectrum antibacterial drug, has the effects of resisting influenza virus, respiratory syncytial virus, adenovirus and herpes virus, and has obvious immunity enhancing effect.

Fructus forsythiae, bitter and slightly cold. Enter the lung, heart and small intestine meridians; clearing away heat and toxic materials, detumescence, resolving hard mass, and dispelling pathogenic wind and heat. Can be used for treating carbuncle, scrofula, acute mastitis, erysipelas, wind-heat type common cold, epidemic febrile disease, excessive heat, polydipsia, coma, speckle, and stranguria due to heat.

Radix Isatidis, bitter and cold. It enters heart and stomach meridians. Clear away heat and toxic materials, cool blood and relieve sore throat. Can be used for treating epidemic febrile, fever, pharyngalgia, epidemic parotitis, throat ulcer, erysipelas, carbuncle, and swelling.

Reed rhizome, rhizoma Phragmitis, sweet and cold. Enter lung and stomach meridians; clearing heat and purging fire, promoting fluid production and quenching thirst, relieving restlessness, preventing vomiting, and promoting urination, and can be used for treating pyretic dysphoria and polydipsia, cough due to lung heat, carbuncle and vomiting due to lung, vomiting due to stomach heat, and stranguria due to heat.

Lalang grass rhizome, rhizoma Imperatae, sweet and cold. Enter lung, stomach and bladder meridians. Cool blood and stop bleeding, clear heat and induce diuresis. Can be used for treating hematemesis, epistaxis, hematuria, pyretic disease, polydipsia, jaundice due to damp-heat, edema, oliguria, and stranguria due to heat.

Huo Xiang, pungent and slightly warm. Enter spleen, stomach and lung meridians. Aromatic, turbid-qi transforming, middle energizer regulating, vomiting relieving, summer-heat relieving. Can be used for treating damp obstruction in middle energizer, gastric fullness and emesis, summer-heat and dampness exterior syndrome, damp warm beginning, fever and listlessness, chest distress and discomfort, cold dampness and summer-heat obstruction, abdominal pain and vomiting and diarrhea, and nasosinusitis headache.

Dahurian angelica root, radix Angelicae Dahuricae, pungent and warm. The stomach, large intestine and lung channels; relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifices, eliminating dampness, stopping leukorrhagia, relieving swelling, and expelling pus, and can be used for treating common cold, headache, glauber bone pain, nasal obstruction, nasal discharge, allergic rhinitis, nasosinusitis, toothache, leukorrhagia, and pyocutaneous disease.

Fructus Tsaoko, pungent and warm. Enter spleen and stomach meridians. Remove dampness and warm middle energizer, check malaria and remove phlegm. Can be used for treating internal cold and dampness, abdominal distention and pain, distention and fullness, emesis, malaria, fever, and epidemic febrile disease. The medicines are combined together to play the roles of clearing heat, detoxicating and eliminating pathogenic factors.

Honeysuckle, weeping forsythiae capsule and radix isatidis all have the effects of clearing heat and detoxicating, reed rhizome purging fire, cogongrass rhizome promoting urination, wrinkled gianthyssop herb for stopping vomiting, dahurian angelica root for dispelling cold and tsaoko amomum fruit for drying dampness. The tea beverage is free of other adjuvants, sweetener, etc., and has sweet taste and no bitter taste after being combined and made into product. Part of raw materials have faint scent (such as sweet taste and faint scent of honeysuckle after soaking in water), and the raw materials are combined and made into products to have faint scent of flowers.

Specifically, the tea drink for preventing influenza is prepared from the following raw materials in parts by weight: 2 parts of honeysuckle, 2 parts of weeping forsythia, 2 parts of radix isatidis, 3 parts of reed rhizome, 3 parts of cogongrass rhizome, 4 parts of wrinkled gianthyssop, 5 parts of radix angelicae and 1 part of tsaoko amomum fruit.

Specifically, the tea drink for preventing influenza is prepared from the following raw materials in parts by weight: 1 part of honeysuckle, 1 part of weeping forsythia, 1 part of radix isatidis, 1 part of reed rhizome, 2 parts of cogongrass rhizome, 3 parts of wrinkled gianthyssop, 2 parts of radix angelicae and 1 part of tsaoko amomum fruit.

Specifically, the tea drink for preventing influenza is prepared from the following raw materials in parts by weight: 3 parts of honeysuckle, 4 parts of weeping forsythia, 2 parts of radix isatidis, 2 parts of reed rhizome, 2 parts of cogongrass rhizome, 2 parts of wrinkled gianthyssop, 3 parts of radix angelicae and 1 part of tsaoko amomum fruit.

Preferably, the granular tea beverage is sterilized with ozone. Ozone sterilization has several effects: firstly, the sterilization effect is better; and secondly, high temperature is not needed, so that high-temperature volatilization of effective substances and volatilization or change of faint scent substances are avoided.

In another aspect, the present invention also provides a preparation method of the tea beverage for preventing influenza, which comprises the following steps:

(1) The preparation of the decoction comprises the following steps: mixing radix Isatidis, rhizoma Phragmitis and lalang grass rhizome at a certain proportion, pulverizing into coarse powder, decocting with 3-6 times of water for 30-45min, decocting for 2-4 times, and mixing decoctions.

(2) Preparing medicinal powder: mixing flos Lonicerae, fructus forsythiae, herba Agastaches, radix Angelicae Dahuricae and fructus Tsaoko at a certain ratio, and pulverizing to obtain fine powder (i.e. the above mentioned medicinal powder).

(3) Concentrating: mixing the decoction with the fine powder according to a certain proportion to obtain a mixed solution, adding 1-4 times of water to ensure uniformity of the fine powder completely dissolved in the decoction, stirring, and vacuum concentrating at 40-60deg.C to 1/8-1/2 of the volume of the mixed solution.

(4) Preparing particles: freeze-drying the concentrated solution, crushing the dried sample into superfine powder, and pressing to form tea beverage in a granule form; the preparation method of the granule is the same as that of the conventional granule.

(5) And (3) sterilization: ozone is adopted for sterilization treatment.

(6) And (3) packaging: quantitatively packaging to obtain the product.

Wherein in step (1), the coarse powder is smaller than 10 mesh or crushed to pass through a first sieve to be not less than 95%. In the step (2), the size of the fine powder is 10-50 meshes. In the step (4), crushing to a size smaller than 200 meshes.

Wherein, in the step (5), the conditions of the ozone sterilization treatment are as follows: the treatment time is 2-4 hours, and the ozone concentration is 8-20ppm.

Specifically, the preparation method of the tea drink for preventing influenza comprises the following steps:

(1) The preparation of the decoction comprises the following steps: mixing radix Isatidis, rhizoma Phragmitis and lalang grass rhizome at a certain proportion, pulverizing into coarse powder smaller than 10 mesh, adding 5 times of water for each time, decocting for 30-45min, decocting for 3 times, and mixing decoctions.

(2) Preparing medicinal powder: mixing flos Lonicerae, fructus forsythiae, herba Agastaches, radix Angelicae Dahuricae and fructus Tsaoko at a certain ratio, and pulverizing to obtain 10-50 mesh fine powder.

(3) Concentrating: mixing the decoction with the fine powder according to the proportion, adding water with the volume of 3 times of that of the mixed solution, stirring uniformly, and concentrating in vacuum at 40-60 ℃ to 1/6 of the volume of the mixed solution.

(4) Preparing particles: freeze-drying the concentrated solution, and crushing and press-forming the dried sample to obtain the tea beverage in the form of granule.

(5) And (3) sterilization: ozone is adopted for sterilization treatment, the treatment time is 2-4 hours, and the ozone concentration is 12ppm.

(6) And (3) packaging: quantitatively packaging in a sterile workshop according to 5 g/bag to obtain the product.

The method of the invention has the following beneficial effects:

(1) Can effectively improve body functions, increase physical strength, strengthen immunity, effectively prevent influenza and is suitable for general people;

(2) Has sweet taste and faint scent, and can be drunk by people for a long time.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in further detail below.

Example 1

The embodiment 1 provides a tea drink for preventing influenza and a preparation method thereof, wherein the tea drink is prepared from the following raw materials in parts by weight: 2 parts of honeysuckle, 2 parts of weeping forsythia, 2 parts of radix isatidis, 3 parts of reed rhizome, 3 parts of cogongrass rhizome, 4 parts of wrinkled gianthyssop, 5 parts of radix angelicae and 1 part of tsaoko amomum fruit. The preparation method comprises the following steps:

(1) The preparation of the decoction comprises the following steps: mixing radix Isatidis, rhizoma Phragmitis and lalang grass rhizome at a certain proportion, pulverizing into coarse powder smaller than 10 mesh, adding 5 times of water, decocting for 30-45min for 3 times, and mixing decoctions.

Example 2

The embodiment 2 provides a tea drink for preventing influenza and a preparation method thereof, wherein the tea drink is prepared from the following raw materials in parts by weight: 1 part of honeysuckle, 1 part of weeping forsythia, 1 part of radix isatidis, 1 part of reed rhizome, 2 parts of cogongrass rhizome, 3 parts of wrinkled gianthyssop, 2 parts of radix angelicae and 1 part of tsaoko amomum fruit. The preparation method is the same as in example 1.

Example 3

The embodiment 3 provides a tea drink for preventing influenza and a preparation method thereof, wherein the tea drink is prepared from the following raw materials in parts by weight: 3 parts of honeysuckle, 4 parts of weeping forsythia, 2 parts of radix isatidis, 2 parts of reed rhizome, 2 parts of cogongrass rhizome, 2 parts of wrinkled gianthyssop, 3 parts of radix angelicae and 1 part of tsaoko amomum fruit. The preparation method is the same as in example 1.

Verification example

1. Test for drinking

5g of the tea drinks of examples 1-3 were taken and placed in 500ml glasses, respectively, and brewed with 300ml boiling water for 5min, and tasting was started when the temperature was reduced to 35.+ -. 5 ℃ and the taste, smell and scores of the different tea drinks were compared, and the results are shown in Table 1:

table 1 mouthfeel test results

Scoring criteria: 1. bitter and astringent; 2. light taste; 3. the fragrance in the mouth is improved; 4. balanced bitter and sweet, and sweet aftertaste; 5. the product is mellow in taste.

As can be seen from Table 1, the tea beverage of the present patent has a sweet or light taste and a faint scent.

2. Influenza prevention test

In order to study the anti-influenza curative effect of the traditional Chinese medicine tea, 100 people of 10-60 years old are selected during the winter influenza epidemic period, and men and women respectively account for half, wherein 10-20 years old 30 people, 20-40 years old 30 people and 40-50 years old 40 people. 100 people are randomly divided into 4 groups according to age groups (namely the 3 age groups), one group, two groups and three groups are respectively brewed with the tea drinks of the examples 1, 2 and 3 every day, and the four groups do not drink tea drinks, and no other medicines capable of preventing and treating influenza are taken in the period. The number of influenza times of the people in 3 months is counted, and the influenza morbidity conditions of the two groups of people are respectively observed, and the results are shown in Table 2:

TABLE 2 influenza prevention Condition list

As can be seen from Table 2, the tea beverages of examples 1-3 were consumed at a low ratio of influenza, whereas the population not consumed the tea beverages had a high ratio of influenza, indicating that the tea beverages of examples 1-3 had influenza preventing effects.

3. Fatigue resistance test

40 mice were screened and divided into 4 groups of 10 mice each, and a load swim test was performed. Taking the products of examples 1-3, infusing with boiling water, concentrating the aqueous solution, and taking the same dosage of the medicines for one month according to the weight of 1ml/50g by stomach infusion, taking the same dosage of physiological saline for stomach infusion by a control group, loading 5% weight lead wire on the root of the tail of a mouse tested object for 30min at last time, putting the mouse tested object into a swimming box for swimming, and measuring the load swimming time of each group of mice. The measured swimming time of the load is subjected to variance alignment test, the requirement of variance alignment is met, statistical treatment is performed by a two-by-two comparison method of average numbers between a plurality of experimental groups and a control group in a single-factor variance analysis method, and the results are shown in Table 3:

TABLE 3 mouse weight bearing swimming time

As can be seen from Table 3, the average swimming time of groups 1-3 was prolonged as compared with the control group, indicating that the prepared tea beverage has antifatigue effect and can enhance the function. Wherein, the swimming time of one group of mice is longest, and the average swimming time of one group of mice, two groups of mice and three groups of mice reaches more than 2 times of that of a control group. The above results indicate that examples 1-3 all have anti-fatigue effects.

In Table 1, examples 1 and 3 are preferred; in Table 2, example 2 is preferred; in Table 3, example 1 is preferred. The formulation of example 2 was used with the corresponding formulation being adjusted as required, if better influenza preventing effect was desired.

The foregoing description of the preferred embodiments of the invention is not intended to limit the invention to the precise form disclosed, and any such modifications, equivalents, and alternatives falling within the spirit and scope of the invention are intended to be included within the scope of the invention.

Claims

1. The tea drink for preventing influenza is characterized by being prepared from the following raw materials in parts by weight: 1-3 parts of honeysuckle, 1-4 parts of weeping forsythiae capsule, 1-2 parts of radix isatidis, 2-3 parts of reed rhizome, 2-3 parts of cogongrass rhizome, 2-4 parts of wrinkled gianthyssop herb, 2-5 parts of dahurian angelica root and 1 part of tsaoko amomum fruit, wherein the radix isatidis, reed rhizome and cogongrass rhizome are prepared into decoction, the honeysuckle, weeping forsythiae capsule, wrinkled gianthyssop herb, dahurian angelica root and tsaoko amomum fruit are prepared into medicinal powder, and the decoction and the medicinal powder are mixed, concentrated in vacuum at low temperature, freeze-dried, crushed and molded to obtain granular tea drink;

the preparation method comprises the following steps:

(1) The preparation of the decoction comprises the following steps: mixing radix Isatidis, rhizoma Phragmitis and lalang grass rhizome at a certain proportion, pulverizing into coarse powder, decocting with 3-6 times of water for 30-45min, decocting for 2-4 times, and mixing decoctions;

(2) Preparing medicinal powder: mixing flos Lonicerae, fructus forsythiae, herba Agastaches, radix Angelicae Dahuricae and fructus Tsaoko at a certain ratio, and pulverizing to obtain fine powder;

(3) Concentrating: mixing the decoction with the fine powder according to the proportion, adding water with the volume of 1-4 times of that of the mixed solution, stirring uniformly, and concentrating in vacuum at 40-60 ℃ to 1/8-1/2 of that of the mixed solution;

(4) Preparing particles: freeze-drying the concentrated solution, and crushing and compression molding the dried sample to obtain tea beverage in a granular dosage form;

(5) And (3) sterilization: ozone is adopted for sterilization treatment;

(6) And (3) packaging: quantitatively packaging to obtain the product.

2. The tea beverage for preventing influenza according to claim 1, which is prepared from the following raw materials in parts by weight: 2 parts of honeysuckle, 2 parts of weeping forsythia, 2 parts of radix isatidis, 3 parts of reed rhizome, 3 parts of cogongrass rhizome, 4 parts of wrinkled gianthyssop, 5 parts of radix angelicae and 1 part of tsaoko amomum fruit.

3. The tea beverage for preventing influenza according to claim 1, which is prepared from the following raw materials in parts by weight: 3 parts of honeysuckle, 4 parts of weeping forsythia, 2 parts of radix isatidis, 2 parts of reed rhizome, 2 parts of cogongrass rhizome, 2 parts of wrinkled gianthyssop, 3 parts of radix angelicae and 1 part of tsaoko amomum fruit.

4. A method for preparing a tea beverage for preventing influenza as claimed in any one of claims 1 to 3, comprising the steps of:

(5) And (3) sterilization: ozone is adopted for sterilization treatment;

(6) And (3) packaging: quantitatively packaging to obtain the product.

5. The process of claim 4 wherein in step (1), the coarse powder is less than 10 mesh in size; in the step (2), the size of the fine powder is 10-50 meshes.

6. The method according to claim 4, wherein in the step (5), the conditions for the ozone sterilization treatment are: the treatment time is 2-4 hours, and the ozone concentration is 8-20ppm.

7. The method of manufacturing according to claim 4, comprising the steps of:

(1) The preparation of the decoction comprises the following steps: mixing radix Isatidis, rhizoma Phragmitis and lalang grass rhizome at a certain proportion, pulverizing into coarse powder smaller than 10 mesh, adding 5 times of water for each time, decocting for 30-45min, decocting for 3 times, and mixing decoctions;

(2) Preparing medicinal powder: mixing flos Lonicerae, fructus forsythiae, herba Agastaches, radix Angelicae Dahuricae and fructus Tsaoko at a certain ratio, and pulverizing to obtain 10-50 mesh fine powder;

(3) Concentrating: mixing the decoction with the fine powder according to the proportion, adding water with the volume of 3 times of that of the mixed solution, stirring uniformly, and concentrating in vacuum at 40-60 ℃ to 1/6 of the volume of the mixed solution;

(5) And (3) sterilization: sterilizing with ozone for 2-4 hr to obtain ozone concentration of 12ppm;

(6) And (3) packaging: quantitatively packaging to obtain the product.