CN1160549A - Concentrated Chinese medicine preparation and its preparation process - Google Patents
Concentrated Chinese medicine preparation and its preparation process Download PDFInfo
- Publication number
- CN1160549A CN1160549A CN 96103415 CN96103415A CN1160549A CN 1160549 A CN1160549 A CN 1160549A CN 96103415 CN96103415 CN 96103415 CN 96103415 A CN96103415 A CN 96103415A CN 1160549 A CN1160549 A CN 1160549A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- medicine preparation
- traditional chinese
- making
- concentrated traditional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Chinese patent drug is water extracted to obtain dry extract, which is further produced into concentrated Chinese medicine preparation by using the water or alcohol solution of fatty acid, sucrose ester and other edible surfactant or their polymer as adhesive and through spraying, drying and fast rotating pelletization. The said Chinese medicine preparation, as grain property analysis and stability test shows, has good fluidity, even grain distribution, excellent moistureproof effect and good disintegrating property, and may be also used in filling capsule or producing troche.
Description
The present invention utilizes water extracting gained dry extract for a kind of with Chinese traditional patent formulation, is adhesive with water, ethanol or its mixed solution of edibility interfacial agents such as fatty acid cane sugar ester or other macromolecular compounds; This Chinese medicine preparation shows through particle characteristics analysis and soundness test, mobile good, even particle distribution, and good moisture effect is arranged, and it is good to collapse the dissolubility of loosing, and can be applicable to capsule charge or directly make ingot, and gained damp proofing effect of finished product and collapsibility are also good.
The application of concentrated traditional Chinese medicine is gradually for popularizing, only because of the mode of taking and Chinese medicine ball, diffusing, cream, DANJI soup, agent such as to fry in shallow oil different, and the Chinese medicine natural goods extract moisture absorption very easily, the excipient that often must add height ratio at existing processing procedure can keep preparation than stability; But because contained composition complexity in the natural goods, most probably with adding excipient produce the reciprocal action that can not expect, influence absorption, metabolism, physicochemical properties change and the stability etc. of active ingredient, and further influence the pharmacological action of preparation and reduce clinical therapeutic efficacy.Therefore, with Chinese crude drug with solvent extracting drying after, add on a small quantity or do not add excipient, the form of Chinese drug that makes stable and high concentration multiple is for needing the emphasis of improvement technology at present.
Though it is many that general concentrated traditional Chinese medicine reduces than Chinese medicine on taking dose, for Western medicine, the still too big and inconvenience of swallowing of taking dose, thereby lower the compliance that sufferer is taken medicine, the use wish reduces, and influences therapeutic process and effect, reduces commodity value.
The objective of the invention is to, overcome above-mentioned shortcoming, a kind of concentrated traditional Chinese medicine preparation and method for making thereof are provided, the present invention utilizes to add the edibility interfacial agent, for example fatty acid cane sugar ester (Sucrose fatty acid esters), fatty acid Pyrusussuriensis sugar ester (Sorbitan fatty acid esters), fatty glyceride (glycerinfatty acid esters) etc. or other macromolecular compounds or do not add excipient, these edibility interfacial agents can use separately or mix use, are to hold Xie Yuhuo to be suspended in water, ethanol or the use of its mixed solution.It is long-pending to reduce Chinese medicine dry extract and air contacting surface in the mixing granulation mode, reaches moistureproof effect, and manufactured goods are through test and the long-time result who observes, and its stability is very high.
Indication of the present invention " Chinese traditional patent formulation " is for having the name of an article, the prescription of former allusion quotation foundation, for example Yizong Jinjian, the collection of prescriptions with notes, Compendium of Materia Medica or outstanding prescriptions such as Chinese medicine voluminous dictionary, Dictionary of Chinese Pharmacy, or the Chinese medicine benchmark side that announces of national health office, have authority and be general confessed Chinese medicine preparation.
The present invention is with the pure water heated and boiled of Chinese medicine composition with 10-20 times of consumption, through gained leachate behind the certain hour, removes partly water in 40 ℃ of-65 ℃ of concentrating under reduced pressure, and obtains dry extract with vacuum drying or spray drying; Again with dry extract; behind fluidized bed spray dryer or rapid mixing comminutor mix homogeneously; add fatty acid cane sugar ester, fatty acid Pyrusussuriensis sugar ester, fatty glyceride or its mixture; its use amount is the 1-15% of dry extract weight; and be dissolved in or be suspended in water, ethanol or its mixed solution, mix then or pelletize number minute after drying and getting.
In order to further specify feature of the present invention and technology contents, see also following relevant detailed description of the present invention.
Embodiment one: the method for making of LIUWEI DIHUANG WAN
The medical material that present embodiment uses is composed as follows:
Radix Rehmanniae Preparata Rehmanniae Radix et Rhizomac 3200 grams
Fructus Corni Corni fructus 1600 grams
Rhizoma Dioscoreae dioscoreae Rhizoma 1600 grams
Rhizoma Alismatis Alismatis Rhizoma 1200 grams
Cortex Moutan Moutan Radicis Cortex 1200 grams
Poria Hoelen 1200 grams
Its step is as follows:
1, above-mentioned medical material is formed 10 kilograms and risen the centrifugal filtration after a few hours of pure water heated and boiled with 100-200.
2, get the leachate of above-mentioned steps 1 gained, after in 40 ℃-65 ℃, concentrating with pressure reducing mode, reuse vacuum or spray pattern dry about 2000 grams of dry extract.
Above raw medicinal herbs is made about 2000 grams of dry extract
Use fatty acid cane sugar ester 100 grams
3, above-mentioned steps 2 gained crude drugs are extracted out about 2000 grams of dry extract and inserted the rapid mixing comminutor, mixed number minute.
4, with fatty acid cane sugar ester 100 gram allocating suitable ethanol, water or ethanol/water mixed liquid dissolving or to suspend it, and sieve with No. 100 or No. 200 screen clothes.
5, with above-mentioned steps 4 gained solution slowly spray add in the above-mentioned steps 3 gained dry extracts, mix or pelletize number minute.
6, move in the fluidized bed spray dryer with 30 ℃ of-75 ℃ of hot air dryings.
7, sieve with No. 20 or No. 24 screen clothes after, get product.
Embodiment two: the method for making of LIUWEI DIHUANG WAN
The medical material that present embodiment uses is formed as embodiment one, and its step is as follows:
1, above-mentioned medical material is formed 10 kilograms and risen the centrifugal filtration after a few hours of pure water heated and boiled with 100-200.
2, get the leachate of above-mentioned steps 1 gained, after in 40 ℃-65 ℃, concentrating with pressure reducing mode, reuse vacuum or spray pattern dry about 2000 grams of dry extract.
Above raw medicinal herbs is made about 2000 grams of dry extract
Use fatty acid cane sugar ester 100 grams
3, above-mentioned steps 2 gained crude drugs are extracted out about 2000 grams of dry extract and inserted the fluidized bed spray dryer, mixed number minute.
4, with fatty acid cane sugar ester 100 gram allocating suitable ethanol, water or ethanol/water mixed liquid dissolving or to suspend it, and sieve with No. 100 or No. 200 screen clothes.
5, with step 4 gained solution slowly spray add in the step 3 gained dry extract, mix or pelletize number minute.
6, continuous with behind 30 ℃ of-75 ℃ of hot air dryings, sieving with No. 20 or No. 24 screen clothes gets product.
Embodiment three: the method for making of decoction of ten powerful tonics
The medical material that present embodiment uses is composed as follows:
Poria Hoelen 1500 grams
Rhizoma Atractylodis Macrocephalae Atractylodis Rhizoma W. 1500 grams
Radix Ginseng Ginseng Radix 1500 grams
Radix Rehmanniae Preparata Rehmanniae Radix et Rhizomac 1500 grams
Radix Paeoniae Alba Paeoniae Lactiflorae Radix 1500 grams
Radix Glycyrrhizae Preparata Glycyrrhizae Radix (Mele) 1500 grams
Radix Astragali Astragail Radix 1500 grams
Cortex Cinnamomi Cinnamomi Bark 1500 grams
Radix Angelicae Sinensis Angelicae Sinensis Radix 1500 grams
Rhizoma Chuanxiong Ligustici Wallichii Rhizoma 1500 grams
Rhizoma Zingiberis Recens Zingiberis Rhizoma 1500 grams
Fructus Jujubae Zizyphi Fructus 1000 grams
Its step is as follows:
1, above-mentioned medical material is formed 17.5 kilograms and risen the centrifugal filtration after a few hours of pure water heated and boiled with 175-350.
2, get the leachate of step 1 gained, after in 40 ℃-65 ℃, concentrating with pressure reducing mode, reuse vacuum or spray pattern dry about 3500 grams of dry extract.
Above raw medicinal herbs is made about 3500 grams of dry extract
Use fatty acid cane sugar ester 175 grams
3, above-mentioned steps 2 gained crude drugs are extracted out about 3500 grams of dry extract and inserted the rapid mixing comminutor, mixed number minute.
4, with fatty acid cane sugar ester allocating the dissolving of suitable ethanol, water or ethanol/water mixed liquid or to suspend it, and sieve with No. 100 or No. 200 screen clothes.
5, with above-mentioned steps 4 gained solution slowly spray add in the above-mentioned steps 3 gained dry extracts, mix or pelletize number minute.
6, move in the fluidized bed spray dryer with 30 ℃ of-75 ℃ of hot air dryings.
7, sieve with No. 20 or No. 24 screen clothes after, get product.
Embodiment four: the method for making of decoction of ten powerful tonics
The medical material that present embodiment uses is formed as embodiment three, and its step is as follows:
1, above-mentioned medical material is formed 17.5 kilograms and risen the centrifugal filtration after a few hours of pure water heated and boiled with 175-350.
Above raw medicinal herbs is made about 3500 grams of dry extract
Use fatty acid cane sugar ester 175 grams
3, above-mentioned steps 2 gained crude drugs are extracted out about 3500 grams of dry extract and inserted the fluidized bed spray dryer, mixed number minute.
4, with fatty ester sucrose ester 175 gram allocating suitable ethanol, water or ethanol/water mixed liquid dissolving or to suspend it, and sieve with No. 100 or No. 200 screen clothes.
5, with above-mentioned steps 4 gained solution slowly spray add in the above-mentioned steps 3 gained dry extracts, mix or pelletize number minute.
6, continuous with behind 30 ℃ of-75 ℃ of hot air dryings, sieving with No. 20 or No. 24 screen clothes gets product.
Embodiment five: the method for making of Antiphlogistic Powder of Schizonepetae and Ledebouriellae
The medical material that present embodiment uses is composed as follows:
Herba Schizonepetae Schizonepetae Herba 1500 grams
Radix Saposhnikoviae Ledebouriellae Radix 1500 grams
Rhizoma Et Radix Notopterygii Notopterygii Rhizoma 1500 grams
Radix Angelicae Pubescentis Angelicae Laxiflorae Radix 1500 grams
Radix Bupleuri Bupleuri Radix 1500 grams
Radix Peucedani Pcucedami Radix 1500 grams
Rhizoma Chuanxiong Ligustici Wallichii Rhizoma 1500 grams
Fructus Aurantii Aurantii Fructus 1500 grams
Radix Platycodonis Platycode Radix 1500 grams
Poria Hoelen 1500 grams
Radix Glycyrrhizae Glycyrrhizae Radix 750 grams
Rhizoma Zingiberis Recens Zingiberis Rhizoma 1500 grams
Herba Menthae Menthae Herba 500 grams
Its step is as follows:
1, above-mentioned medical material is formed 17.75 kilograms and risen the centrifugal filtration after a few hours of pure water heated and boiled with 177-355.
2, get the leachate of step 1 gained, after concentrating with pressure reducing mode in 40 ℃-65 ℃, reuse vacuum or spray pattern are dry that dry extract be about 3550 grams.
Above raw medicinal herbs is made about 3550 grams of dry extract
Use fatty acid cane sugar ester 180 grams
3, above-mentioned steps 2 gained crude drugs are extracted out about 3550 grams of dry extract and inserted the rapid mixing comminutor, mixed number minute.
4, with fatty acid cane sugar ester 180 gram allocating suitable ethanol, water or ethanol/water mixed liquid dissolving or to suspend it, and sieve with No. 100 or No. 200 screen clothes.
5, with above-mentioned steps 4 gained solution slowly spray add in the above-mentioned steps 3 gained dry extracts, mix or pelletize number minute.
6, move in the fluidized bed spray dryer with 30 ℃ of-75 ℃ of hot air dryings.
7, sieve with No. 20 or No. 24 screen clothes after, get product.
Embodiment six: the method for making of Antiphlogistic Powder of Schizonepetae and Ledebouriellae
Composition that present embodiment uses such as embodiment five, its step are as follows:
1, above-mentioned medical material is formed 17.75 kilograms and risen the centrifugal filtration after a few hours of pure water heated and boiled with 177-355.
2, get the leachate of step 1 gained, after concentrating with pressure reducing mode in 40 ℃-65 ℃, reuse vacuum or spray pattern are dry that dry extract be about 3550 grams.
Above raw medicinal herbs is made about 3550 grams of dry extract
Use fatty acid cane sugar ester 180 grams
3, above-mentioned steps 2 gained crude drugs are extracted out about 3550 grams of dry extract and inserted the fluidized bed spray dryer, mixed number minute.
4, with fatty ester sucrose ester 180 gram allocating suitable ethanol, water or ethanol/water mixed liquid dissolving or to suspend it, and sieve with No. 100 or No. 200 screen clothes.
5, with above-mentioned steps 4 gained solution slowly spray add in the step 3 gained dry extract, mix or pelletize number minute.
6, continuous with behind 30 ℃ of-75 ℃ of hot air dryings, with No. 20 or sieve with No. 24 nets and to get product.
In the foregoing description, the fatty ester sucrose ester can substitute with fatty ester Pyrusussuriensis sugar ester or fatty ester glyceride, and its effect is suitable.
Embodiment seven
The Chinese medicine preparation that the embodiment of the invention one to six is made, utilize the method for general test stability and moisture resistance, quicken soundness test, thin layer chromatographic analysis comparison and water content determination test, test condition is a relative humidity 75%, the determination of moisture condition is 80 ℃, 30 minutes dry losss of weight.Its test result is that table one is to table three.
Table one is the test result of LIUWEI DIHUANG WAN (embodiment one and embodiment two).
Table two is the test result of decoction of ten powerful tonics (embodiment three and embodiment four).
Table three is the test result of Antiphlogistic Powder of Schizonepetae and Ledebouriellae (embodiment five and embodiment six).
Can find out Chinese medicine preparation of the present invention by table one to table three, the moisture absorption time is long, and the moisture absorption degree is low, that is has good moisture resistance and stability.
Claims (7)
1, a kind of concentrated traditional Chinese medicine preparation and method for making thereof is characterized in that, comprise the following steps:
1) with an amount of Chinese traditional patent formulation in addition the pure water of 10-20 times of consumption boil together, obtain leachate and concentrate, and gained dry extract after vacuum drying or the spray drying;
2) again with behind fluidized bed spray dryer or the rapid mixing comminutor mix homogeneously; add fatty acid cane sugar ester, fatty acid Pyrusussuriensis sugar ester, fatty glyceride or its mixture; its use amount is the 1-15% of dry extract weight; and be dissolved in or be suspended in water, ethanol or its mixed solution, form through sieving after mixing, pelletize, the drying.
2, by described concentrated traditional Chinese medicine preparation of claim 1 and method for making thereof, it is characterized in that the use amount of said fatty acid cane sugar ester, fatty acid Pyrusussuriensis sugar ester, fatty glyceride is good with respect to the 4-10% of dry extract.
3, by described concentrated traditional Chinese medicine preparation of claim 1 and method for making thereof, it is characterized in that said pelletize or exsiccant temperature are 30 ℃-75 ℃.
4,, it is characterized in that said concentrated traditional Chinese medicine preparation is to make by claim 1,2 or 3 method for making by described concentrated traditional Chinese medicine preparation of claim 1 and method for making thereof.
5, by described concentrated traditional Chinese medicine preparation of claim 1 and method for making thereof, it is characterized in that said concentrated traditional Chinese medicine preparation can be made Chinese medicine granules, cooperates excipient again.
6, by described concentrated traditional Chinese medicine preparation of claim 1 and method for making thereof, it is characterized in that said concentrated traditional Chinese medicine preparation can be made the Chinese medicinal capsule agent, cooperates excipient again.
7, by described concentrated traditional Chinese medicine preparation of claim 1 and method for making thereof, it is characterized in that said concentrated traditional Chinese medicine preparation can be made Chinese medicine lozenge, cooperates excipient again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96103415A CN1067256C (en) | 1996-03-21 | 1996-03-21 | Concentrated chinese medicine preparation and its preparation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96103415A CN1067256C (en) | 1996-03-21 | 1996-03-21 | Concentrated chinese medicine preparation and its preparation process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1160549A true CN1160549A (en) | 1997-10-01 |
| CN1067256C CN1067256C (en) | 2001-06-20 |
Family
ID=5118061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96103415A Expired - Fee Related CN1067256C (en) | 1996-03-21 | 1996-03-21 | Concentrated chinese medicine preparation and its preparation process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1067256C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101755975A (en) * | 2010-01-25 | 2010-06-30 | 中山市新运来医药科技开发有限公司大涌分公司 | Chinese herbal medicine sugar and tea drink preparation for preventing and treating cold |
| CN103432557A (en) * | 2013-09-04 | 2013-12-11 | 周冠旻 | Medicine for treating cold of pig |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100389818C (en) * | 2006-01-10 | 2008-05-28 | 孙小五 | Medicinal soap for treating pruritus and preparation method thereof |
-
1996
- 1996-03-21 CN CN96103415A patent/CN1067256C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101755975A (en) * | 2010-01-25 | 2010-06-30 | 中山市新运来医药科技开发有限公司大涌分公司 | Chinese herbal medicine sugar and tea drink preparation for preventing and treating cold |
| CN103432557A (en) * | 2013-09-04 | 2013-12-11 | 周冠旻 | Medicine for treating cold of pig |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1067256C (en) | 2001-06-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101073606A (en) | Method for separating and extracting white Peony Root | |
| CN1583086A (en) | Chinese medicine for relieving exterior syndrome, regulating stomach and eliminatnig dampness and its production | |
| CN101057925A (en) | Preparation technology for 'jieguqili' capsule and its quality control method | |
| CN1895462A (en) | Nankang soft capsule for treating prostatitis | |
| CN1891284A (en) | Chinese medicine composition, and its preparing method and quality control method | |
| CN1067256C (en) | Concentrated chinese medicine preparation and its preparation process | |
| CN1226033C (en) | Method for preparing traditional Chinese medicine concentrated pill | |
| CN1319573C (en) | Chinese medicine composition for treating osteoporosis and preparing method | |
| CN1289115C (en) | Immunity raising Chinese medicine and its prepn process | |
| CN1586612A (en) | Process for preparing granular powder for treating blood stasis disease and quality control method | |
| CN101036739A (en) | Chinese medicine preparation for treating stomach-ache and its preparation process | |
| CN1316960C (en) | Compound mactra clam drip pill and its preparation method | |
| CN100341489C (en) | Xianling gubao dripping pills having functions of reinforcing kidney strengthening bone, and its prepn method | |
| CN1369306A (en) | 'Huajuhong' preparation and its preparing process | |
| CN1824078A (en) | Green biota body cleaning effervescent particle preparation | |
| CN1424085A (en) | Process for preparing Tibet medicine | |
| CN1319572C (en) | Coating method for Chinese medicine Zuogui granule | |
| CN1695728A (en) | Oral taking preparation of Chinese traditional medicine for nourishing the kidney and the lung | |
| CN1481873A (en) | Novel preparation method for ageratum zhengqi capsule | |
| CN1569178A (en) | Chinese medicine oral preparation for treating gynecologic inflammation and its preparation method | |
| CN1316962C (en) | Cough panting quieting drip pill and its preparation method | |
| CN1457809A (en) | Dandelion preparation and preparing method | |
| CN1559527A (en) | Compound stemona cough stopping medicine and its preparation method | |
| CN1569197A (en) | Chinese medicinal soft capsule and preparing process thereof | |
| CN1368151A (en) | Nano medicine 'Hailong Gejie' and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: CORRECT ZHENGFUNG BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: CHINA CHEMICAL PHARMACEUTICAL CO., LTD. Effective date: 20020927 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20020927 Address after: Tai Wansheng Patentee after: HSBC biotech, Limited by Share Ltd Address before: No. 23, Xiangyang Road, Taipei, Taiwan Patentee before: China Chemical Pharmaceutical Co., Ltd. |
|
| C56 | Change in the name or address of the patentee |
Owner name: HUAYUN BIOLOGICAL TECHNOLOGY CO., LTD. Free format text: FORMER NAME OR ADDRESS: CORRECT ZHENGFUNG BIOTECHNOLOGY CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Patentee after: China Bio Polytron Technologies Inc Patentee before: HSBC biotech, Limited by Share Ltd |
|
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |