CN116034984A - Perfusion system for multiple cardiac coronary arteries - Google Patents
Perfusion system for multiple cardiac coronary arteries Download PDFInfo
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- CN116034984A CN116034984A CN202211249138.6A CN202211249138A CN116034984A CN 116034984 A CN116034984 A CN 116034984A CN 202211249138 A CN202211249138 A CN 202211249138A CN 116034984 A CN116034984 A CN 116034984A
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- solution tank
- coronary arteries
- perfusion
- upper solution
- perfusion system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
Abstract
The invention belongs to the technical field of medical appliances, and particularly relates to a perfusion system for a plurality of hearts. A perfusion system for a plurality of hearts includes a frame, an upper solution tank, a liquid level sensing system, a lifting mechanism, a valve switch, a lower solution tank, an exhaust system, electrical control components, and a liquid circulation system. According to the invention, the height of the upper solution tank is freely adjusted through the lifter, and the relative heights of the upper solution tank and the lower solution tank are adjustable within the range of 1-1.5m, so that the heart is in a full state; the device has the positive advantages of simplicity in operation and strong practicability.
Description
Technical Field
The invention belongs to the technical field of medical appliances, and particularly relates to a perfusion system for a plurality of heart coronary arteries.
Background
The safety and the effectiveness of the medical instrument used in the prior coronary intervention operation are verified by an animal experiment method before clinic, the clinical operation mode is simulated firstly by the verification mode, the coronary intervention operation is performed on an experimental animal by using the medical instrument, a certain period of follow-up visit is performed after the operation according to a formulated experimental scheme, the treatment condition of the coronary is observed, and finally, the treated harrow blood vessel and adjacent blood vessel tissues are sent to pathological examination together through the anatomical material drawing of the experimental animal, so that the damage condition of the instrument to the blood vessel is further judged.
It is known that once a living body dies, no fresh flowing blood circulation exists, blood vessels collapse immediately, and a time difference exists between taking samples from animal anatomy and sending the samples to a pathology department for pathological detection for at least 24 hours, which greatly influences the accuracy of the detection of the blood vessels of the samples, so that the true results of animal experiments of medical instruments cannot be judged.
A perfusion system for a plurality of heart coronary arteries can solve the problem of collapse and deterioration of blood vessels of an isolated sample, restore the real tissue condition of the blood vessels of the sample to the maximum extent when a pathology experiment is carried out, and provide a reliable detection result.
Chinese patent application number CN202110540466.0 discloses a device for maintaining harvested hearts to be transplanted, by perfusing the hearts, to achieve maintenance of excised hearts, waiting to be accepted, but is limited to maintenance of only one heart. Therefore, the mechanical perfusion system which can prevent the collapse and deterioration of the isolated cardiac coronary artery blood vessel and keep the cardiac blood vessel in a good physiological activity state in the long-time isolated preservation process is a problem which needs to be solved at present.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a synchronous heart perfusion combined device capable of simultaneously perfusing formalin solution or physiological saline into heart coronary arteries of animals with certain body types, such as a plurality of experimental animals (pigs, dogs, sheep) and the like.
The technical scheme adopted for solving the technical problems is as follows:
the perfusion system for the hearts sequentially comprises a frame, a lower solution tank, a liquid level sensing system, a valve switch, a lifting mechanism, an upper solution tank and an exhaust system from bottom to top; the electric control component is connected with the lifting mechanism and used for controlling the lifting mechanism to move up and down; the lifting mechanism is connected with the upper solution tank and used for controlling the upper solution tank to move up and down.
Preferably, the perfusion system further comprises an electrical control component, a liquid circulation system.
Preferably, the electrical control component is connected with the liquid level sensing system and is used for detecting the height of the perfusate of the upper solution tank and the lower solution tank.
Preferably, the electrical control component is connected with the valve switch and is used for controlling the flow of the perfusate in the upper solution tank.
Preferably, the electrical control component is connected with the exhaust system and is used for exhausting toxic gas in the box body.
Preferably, the electrical control component is connected to the fluid circulation system for powering the perfusate.
Further preferably, the lifting mechanism comprises a first power mechanism, a guide rail, a sliding block and a support; the sliding block is connected with the guide rail; the supporting piece is connected with the upper solution tank.
Further preferably, the liquid level sensing system comprises a low liquid level detection and an over water level detection.
Further preferably, the exhaust system comprises an exhaust duct and a second power mechanism.
Further preferably, the fluid circulation system comprises a perfusion fluid filtering device and an infusion fluid delivery conduit; the perfusion conveying pipeline comprises a conveying conduit and an output conduit, the upper solution tank is connected with the central viscera of the lower solution tank through the conveying conduit, and the lower solution tank is connected with the upper solution tank through the output conduit.
Further preferably, the electrical control component comprises a timing module, a signal transmission device and a buzzer system.
The inventor creatively discovers in experiments that a plurality of experimental animals of one project can have heart sample injection needed by each heart when the heart is perfused, for example, the time required by each heart to perfuse one by one can be long, the timeliness of pathology delivery is influenced, so that the animal heart samples needed by experiments are perfused together, the perfusion time is saved, and experimental data which does not influence the judgment of pathology can be obtained.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the invention, the height of the upper solution tank is freely adjusted through the lifter, and the relative heights of the upper solution tank and the lower solution tank are adjustable within the range of 1-1.5m, so that the coronary arteries of the heart are in a full state.
2. The upper solution tank and the lower solution tank in the system are both provided with liquid level sensing systems, and the low liquid level or the super water level can give an alarm.
3. 10-20 sample hearts can be simultaneously placed for perfusion at one time, the mutual interference is avoided, the heart perfusion is performed controllably, and the in vitro heart of animals is successfully perfused by formalin solution.
4. The device has the positive advantages of simplicity in operation and strong practicability.
The perfusion system for a plurality of hearts works on the principle that: before starting up, checking whether all circuits are normal, whether a waterway leaks or not, after preparation, pouring formalin solution into an upper solution box, wherein the liquid level of the formalin solution is between a low liquid level detection water level and a super water level detection, placing a heart sample to be tested in a lower solution box, connecting a heart blood inlet to a liquid outlet on the solution box, covering a solution box cover with a lock catch, opening a corresponding valve on a touch screen, after the valve is opened, enabling solution in the upper solution box to flow from gravity into the heart, and then flowing out from a heart outlet into the lower solution box, regulating the height of the upper solution box by observing the state of the heart, and after the solution in the upper solution box is reduced by a certain amount, automatically opening a magnetic pump to pump the solution in the lower solution box into the upper solution box again, so that the solution is circulated and reciprocated.
Drawings
Embodiments of the present invention will now be described more fully with reference to the accompanying drawings. The drawings, however, are for illustration and description only and are not to be construed as limiting the scope of the invention.
Fig. 1 is a schematic diagram of a perfusion system for multiple hearts according to the present invention.
Fig. 2 is a schematic perspective view of a perfusion system for multiple hearts according to the present invention.
The serial numbers in the figure are: the infusion apparatus comprises a frame 1, an upper solution tank 2, a first liquid level sensor 3, a lifting mechanism 4, a valve switch 5, a lower solution tank 6, a second liquid level sensor 7, an air suction pipeline 8, a second power mechanism 9, an electrical control component 10, a first power mechanism 11, a guide rail 12, a sliding block 13, a first supporting piece 14, a second supporting piece 15, a third supporting piece 16, an infusion solution filtering device 17, a conveying pipeline 18, an output pipeline 19, an infusion solution conveying pipeline 20, a solution circulating pump 21 and a heart 22.
Detailed Description
The invention will be further described with reference to the drawings and specific examples, which are not intended to be limiting.
Example 1 construction and connection of a mechanical perfusion system for heart preservation.
In this embodiment, as shown in fig. 1, a cardiac perfusion arrangement includes a frame 1, an upper solution tank 2, a liquid level sensing system, a lifting mechanism 4, a valve switch 5, a lower solution tank 6, an exhaust system, an electrical control component 10, and a liquid circulation system; the electrical control component is connected with the lifting mechanism 4 and used for controlling the lifting machine to move up and down; the lifting mechanism is connected with the upper solution tank and used for controlling the upper solution tank to move up and down; the electric control component 10 is connected with the liquid level sensing system and is used for detecting the height of the perfusate of the upper solution tank and the lower solution tank; an electrical control element 10 is connected to the valve switch 5 for controlling the flow of the solution; the electrical control component 10 is connected with an exhaust system and is used for exhausting toxic gas in the box body; the electrical control component 10 is connected with the liquid circulation system and is used for providing power for the perfusate; the lifting mechanism 4 comprises a first power mechanism 11, a guide rail 12, a sliding block 13 and a supporting piece; the sliding block is connected with the guide rail; the supporting piece is connected with the upper solution tank; the liquid level sensing system comprises low liquid level detection and super water level detection; the exhaust system comprises an exhaust pipeline 8 and a second power mechanism 9; the liquid circulation system comprises a perfusion liquid filtering device 17, an infusion liquid conveying pipeline 20 and a solution circulation pump 21; the perfusion conveying pipeline 20 comprises a conveying conduit 18 and an output conduit 19, the upper solution tank is connected with the central viscera of the lower solution tank through the conveying conduit, and the lower solution tank is connected with the upper solution tank through the output conduit; the electrical control component 10 comprises a timing module, a signal transmission device and a buzzer system.
Fig. 1 provides a schematic illustration of the perfusion system for multiple hearts.
Fig. 2 provides a schematic perspective view of the perfusion system for multiple hearts.
The infusion liquid delivery conduit comprises a plurality of parallel conduits including an infusion liquid delivery conduit 18 disposed on the end side.
The support members include a first support member 14, a second support member 15, and a third support member 16. The liquid level sensing system comprises a first liquid level sensor 3 and a second liquid level sensor 7.
Before starting up, checking whether a circuit is normal, whether a waterway leaks or not, pouring a proper amount of formalin solution into an upper solution tank after the waterway is ready, wherein the solution height in the upper solution tank is in the middle of a low liquid level detection water level and an excessive water level detection water level, the low liquid level detection water level is 3cm away from the bottom end of the upper solution tank, and the excessive water level detection water level is 20cm away from the bottom end of the upper solution tank; after pouring, placing heart samples to be tested into a lower solution box, wherein in the embodiment, the number of the heart samples is 15, and connecting a heart blood inlet to a liquid outlet on the solution box; after the installation is finished, the cover of the solution box is covered with a lock catch, a corresponding valve is opened on a touch screen in an electric control component, after the valve is opened, solution in the upper solution box flows into a heart from gravity and flows out of a heart outlet into a lower solution box, the height of the upper solution box is adjusted through the electric control component so that a heart sample is in a full state, and in the embodiment, the height of the upper solution box is 1.2m; when the solution in the upper solution tank is lower than the low liquid level detection water level, the magnetic pump can be automatically opened to pump the solution in the lower solution tank into the upper solution tank again, and the above steps are repeated.
Claims (10)
1. A perfusion system for a plurality of immediate isolated coronary arteries, which is characterized by sequentially comprising a frame, a lower solution tank, a liquid level sensing system, a valve switch, a lifting mechanism, an upper solution tank and an exhaust system from bottom to top; the electric control component is connected with the lifting mechanism and used for controlling the lifting mechanism to move up and down; the lifting mechanism is connected with the upper solution tank and used for controlling the upper solution tank to move up and down.
2. The perfusion system for a plurality of cardiac coronary arteries according to claim 1, further comprising an electrical control component, a fluid circulation system.
3. The perfusion system for a plurality of cardiac coronary arteries according to claim 2, wherein the electrical control component is connected to the level sensing system for detecting the level of perfusate in the upper and lower solution tanks; the electric control component is connected with the valve switch and used for controlling the flow of the perfusate in the upper solution tank.
4. The perfusion system for the coronary arteries of the heart of claim 2, wherein the electrical control component is coupled to the exhaust system for exhausting toxic gases from the housing.
5. The perfusion system for a plurality of cardiac coronary arteries according to claim 2, wherein the electrical control component is coupled to the fluid circulation system for powering the perfusate.
6. The perfusion system for a plurality of cardiac coronary arteries according to any one of claims 1 to 5, wherein the lifting mechanism comprises a first power mechanism, a rail, a slider and a support; the sliding block is connected with the guide rail; the supporting piece is connected with the upper solution tank.
7. The perfusion system for a plurality of cardiac coronary arteries according to claim 3, wherein the fluid level sensing system comprises a low fluid level detection and an over-water level detection.
8. The perfusion system for a plurality of cardiac coronary arteries according to claim 4, wherein the exhaust system comprises an exhaust duct and a second power mechanism.
9. The perfusion system for a plurality of cardiac coronary arteries according to claim 5, wherein the fluid circulation system comprises a perfusate filtering device and an perfusate delivery conduit; the perfusion conveying pipeline comprises a conveying conduit and an output conduit, the upper solution tank is connected with the central viscera of the lower solution tank through the conveying conduit, and the lower solution tank is connected with the upper solution tank through the output conduit.
10. The perfusion system for a plurality of cardiac coronary arteries according to claim 2, wherein the electrical control components include a timing module, a signal transmission device, and a buzzer system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211249138.6A CN116034984A (en) | 2022-10-11 | 2022-10-11 | Perfusion system for multiple cardiac coronary arteries |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211249138.6A CN116034984A (en) | 2022-10-11 | 2022-10-11 | Perfusion system for multiple cardiac coronary arteries |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116034984A true CN116034984A (en) | 2023-05-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211249138.6A Pending CN116034984A (en) | 2022-10-11 | 2022-10-11 | Perfusion system for multiple cardiac coronary arteries |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116034984A (en) |
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2022
- 2022-10-11 CN CN202211249138.6A patent/CN116034984A/en active Pending
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