CN115999658A - Microfluidic chip for drug delivery system - Google Patents
Microfluidic chip for drug delivery system Download PDFInfo
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- CN115999658A CN115999658A CN202210821014.4A CN202210821014A CN115999658A CN 115999658 A CN115999658 A CN 115999658A CN 202210821014 A CN202210821014 A CN 202210821014A CN 115999658 A CN115999658 A CN 115999658A
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- delivery system
- drug delivery
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- microfluidic chip
- flow dividing
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Abstract
The invention discloses a chip body, wherein a flow channel for mixing liquid is arranged in the chip body, a plurality of flow dividing devices are arranged in the middle of the flow channel, and a flow dividing part is arranged at the center of the inner part of the flow dividing devices, so that solutions can be continuously fused and separated, the mixing effect is better, and meanwhile, the time required for mixing is shortened. The device can realize that the parameters of the sample are completely controllable in the process of continuous preparation, and the conveying speed of the injector can be controlled, so that two-phase liquid can be subjected to different impact forces and shearing forces during mixing, and the preparation of samples with different particle diameters is realized.
Description
Technical Field
The invention relates to the field of microfluidic chips, in particular to a microfluidic chip for a drug delivery system.
Background
The microfluidic chip technology is based on the hydrodynamic theory, integrates basic operation units such as sample preparation, reaction, separation, detection and the like in biological, chemical and medical analysis processes on a micro-scale chip, precisely controls and controls micro-scale fluid in a micro-nano structure of the chip, and automatically completes the whole analysis process. The great potential of microfluidic chip technology in the fields of biology, chemistry, medicine and the like has been developed into a brand-new research field crossing disciplines of biology, chemistry, medicine, fluid, electronics, materials, machinery and the like.
The microfluidic chip of publication number CN 113828366A provides a liquid mixing flow path, and by providing an inverted "S" flow path and a spiral flow path, gas and liquid can be sufficiently mixed, but because the flow path is provided longer, the mixing time is also longer, and the device cannot prepare the particle size of the mixed sample.
Disclosure of Invention
The invention aims to solve the defects in the prior art, and provides a microfluidic chip for a drug delivery system.
In order to achieve the above purpose, the present invention adopts the following technical scheme: a microfluidic chip for a drug delivery system, comprising: the chip body, the inside of chip body is equipped with the runner that makes liquid carry out the mixture, be equipped with a plurality of diverging device in the middle of the runner, the inside centre of a circle department of diverging device is equipped with the reposition of redundant personnel part, can make the solution constantly fuse the separation, when making the mixing effect better, shortens the required time of mixing.
As a further description of the above technical solution: the shape of the runner is Y-shaped, the upper part is an A section and a B section for liquid inlet, the flow dividing device is arranged at the output section below, and the output section is arc-shaped.
As a further description of the above technical solution: the outer side of the chip body is provided with a first luer connector, a second luer connector and a liquid outlet column.
As a further description of the above technical solution: the liquid inlet pipe wall of the first luer connector is communicated with the section A above the flow channel, and the liquid inlet pipe wall of the second luer connector is communicated with the section B above the flow channel; after the two liquids are fully mixed, the two liquids flow out of the liquid outlet column.
As a further description of the above technical solution: after two liquids are contacted, the two liquids enter the first flow dividing device on the output section, the mixed liquid is separated at the flow dividing part of the first flow dividing device, and then the two liquids are mixed again after passing through the annular flow passage, and the two liquids enter the second flow dividing device, the third flow dividing device and the fourth flow dividing device in sequence in the same mode.
As a further description of the above technical solution: luer external threads are arranged on the outer sides of ports of the first luer connector and the second luer connector, and the luer external threads are used for connecting with a syringe.
As a further description of the above technical solution: and the oblique flushing liquid inlet angle of the section A and the section B in the flow channel is B.
As a further description of the above technical solution: and an included angle a is formed between the flow passages of each three flow dividing devices for buffering.
As a further description of the above technical solution: grooves are formed in two sides of the chip body.
As a further description of the above technical solution: and (3) controlling the injection speed of the injector to ensure that the speed of liquid entering the first luer connector is different from that of liquid entering the second luer connector, so as to prepare samples with different particle sizes.
The technical scheme has the following advantages or beneficial effects:
1. in the continuous preparation process of the samples, parameters in the process are completely controllable, and the conveying speed of the injector can be controlled, so that two-phase liquid is subjected to different impact forces and shearing forces during mixing, and samples with different particle sizes are prepared.
2. And a flow dividing device is arranged, so that AB two-phase liquid is subjected to step-by-step cross convection in a tortuous channel to be fully mixed and reacted, and the uniformity and consistency of products are improved.
3. The flow dividing device is internally provided with a flow dividing component which can separate the AB phases and enable the AB phases to react step by step in sequence, so that the opposite flow velocity is increased, and the flow direction of the AB phases is adjusted.
4. The output section is arranged in an arc shape, so that the turbulence of the mixed liquid can be increased, the path is prolonged, and the reaction time is prolonged.
5. The angles of the section A and the section B in the flow channel and the included angles of the plurality of flow dividing devices can be adjusted according to actual production conditions.
Drawings
Fig. 1 is a perspective view of a microfluidic chip for a drug delivery system according to the present invention;
fig. 2 is a front view of a microfluidic chip for a drug delivery system according to the present invention;
fig. 3 is a right side view of a microfluidic chip for a drug delivery system according to the present invention;
fig. 4 is an internal structure diagram of a microfluidic chip for a drug delivery system according to the present invention;
fig. 5 is a partial flow chart of a microfluidic chip for a drug delivery system according to the present invention;
fig. 6 is a partial perspective view of a microfluidic chip for a drug delivery system according to the present invention.
Legend description:
1. a first luer fitting; 2. a second luer fitting; 3. a liquid column is discharged; 4. a flow passage; 5. luer external threads; 6. a groove; 7. a chip body; 100. a shunt member; 200. an output section; 300. and a shunt device.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1-6, one embodiment provided by the present invention is: a microfluidic chip for a drug delivery system, comprising: the chip body 7, the inside of chip body 7 is equipped with the runner 4 that makes liquid mix, be equipped with a plurality of diverging device 300 in the middle of the runner 4, the centre of a circle department of diverging device 300 inside is equipped with the reposition of redundant personnel part 100, can make the solution constantly fuse the separation, when making the mixing effect better, shortens the required time of mixing.
The liquid entering the flow channel 4 can be mixed and split for multiple times by the splitting device 300 and the splitting component 100 therein, so that the liquid can be fully and uniformly mixed.
Further, the flow channel 4 is Y-shaped, the upper part is a section a and a section B for feeding liquid, the flow dividing device 300 is disposed at the lower output section 200, and the output section 200 is arc-shaped.
The two liquids enter the flow dividing device 300 to be mixed through the section A and the section B, the mixed liquid enters the output section 200, the output section 200 is arc-shaped, the turbulence of the mixed liquid can be increased, the path is prolonged, and the reaction time is prolonged.
Further, a first luer connector 1, a second luer connector 2 and a liquid outlet column 3 are arranged on the outer side of the chip body 7.
The liquid can be mixed and output after entering the microfluidic chip.
Further, the liquid inlet pipe wall of the first luer connector 1 is communicated with the section A above the flow channel 4, and the liquid inlet pipe wall of the second luer connector 2 is communicated with the section B above the flow channel 4; after the two liquids are fully mixed, the mixture flows out of the liquid outlet column 3.
Two different liquids can be respectively made to enter the section A of the flow channel 4 from the first luer connector 1, the second luer connector 2 enters the section B of the flow channel 4, and then enter the output section 200 after being mixed, and flow out from the liquid outlet column 3 connected with the output section 200.
Further, after the two liquids contact, the two liquids enter the first flow dividing device on the output section 200, the mixed liquid is separated at the flow dividing part 100 of the first flow dividing device, and then mixed again after passing through the annular flow channel, and the two liquids enter the second flow dividing device, the third flow dividing device and the fourth flow dividing device in sequence in the same way.
The two liquids enter the output section 200 to be prepared by mixing after contacting, enter from the input port of the first flow dividing device, enable the mixed liquid to be separated for the first time under the blocking of the flow dividing component 100, continuously flow downwards along the flow channel of the first flow dividing device from two sides, enable the separated liquid to be mixed again through the annular flow channel, flow into the second flow dividing device, repeat the flow dividing process, sequentially enter the second flow dividing device, and enable the third flow dividing device and the fourth flow dividing device to achieve multiple mixing and separation, and achieve better mixing effects.
Further, luer external threads 5 are arranged on the outer sides of the ports of the first luer connector 1 and the second luer connector 2, and the luer external threads 5 are used for connecting with a syringe.
Luer connectors are convenient connection devices used in the medical industry, and can realize quick connection and disassembly of the syringe.
Further, the oblique flushing inlet angles of the section A and the section B in the flow channel 4 are B.
Different oblique flushing liquid inlet angles can be designed according to actual conditions, and the angle b range in the embodiment is 85-120 degrees; when the liquid enters the chip for mixing, the directions of the impact force and the shearing force are different, so that different stress effects are achieved, and the liquid can be used for preparing mixed liquids with different particle sizes.
Further, the flow paths of each three of the flow dividing devices 300 form an included angle a for buffering.
The liquid can be fully mixed and reacted in the tortuous channel through the flow dividing device 300 by step-by-step cross convection, and the impact force of the liquid can be relieved, so that the flow direction is changed, and the liquid can react in the chip for a longer time; the degree of the included angle a in this embodiment is selected to be 120 °.
Further, grooves 6 are formed on two sides of the chip body 7.
The chip can be clamped and fastened through the spherical plunger when the chip is installed, and the spherical plunger is far away from the structure 6 under the action of external force when the chip is taken down, so that the chip is clamped, fixed and loosened.
Further, by controlling the injection speed of the syringe, the liquid is made to have different speeds in the first luer connector 1 and the second luer connector 2, so as to prepare samples with different particle sizes.
The liquid can be conveyed into the chip at a constant speed in a certain proportion by controlling the injector to mix, and the sample can reach a turbulent flow or laminar flow state in the microfluidic chip by controlling the speed of the two-phase liquid entering the chip, so that the preparation of samples with different particle diameters can be realized under different impact forces and shearing forces, the minimum particle diameter can be within 100nm, and the PDI (polymer dispersion index) can be below 0.3.
Working principle: the chip body 1 is provided with a first luer connector 1, a second luer connector 2 and a liquid outlet column 3, luer external threads 5 are arranged on the periphery of the two liquid inlet columns, and the injector can be better fixed; different syringes control liquid to enter the flow channel 4 from the first luer connector 1 and the second luer connector 2 at a constant speed in a certain proportion, the speed of the two-phase liquid entering the chip is controlled, so that samples reach turbulence or laminar flow states in the microfluidic chip, the preparation of the samples with different particle sizes is realized under different impact forces and shearing forces, the included angles of the flow channels of the section A and the section B adopt an inclined flushing liquid inlet angle of 85-120 degrees according to different requirements, the flow dividing device 300 is provided with four flow dividing devices, a serial structure is adopted, the included angles of the flow channels between three continuous flow dividing devices adopt a 120-degree design, the force of opposite flushing reaction is increased, and the mixed prepared liquid is output from the liquid outlet column 3 through the output section 200.
Finally, it should be noted that: the foregoing description is only illustrative of the preferred embodiments of the present invention, and although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described, or equivalents may be substituted for elements thereof, and any modifications, equivalents, improvements or changes may be made without departing from the spirit and principles of the present invention.
Claims (10)
1. A microfluidic chip for a drug delivery system, comprising: chip body (7), its characterized in that: the inside of chip body (7) is equipped with runner (4) that make liquid mix, be equipped with a plurality of diverging device (300) in the middle of runner (4), the centre of a circle department of diverging device (300) inside is equipped with diverging component (100), can make the solution constantly fuse the separation, when making the mixing effect better, shortens the required time of mixing.
2. The microfluidic chip for a drug delivery system according to claim 1, wherein: the flow channel (4) is Y-shaped, the upper part is an A section and a B section for liquid inlet, the flow dividing device (300) is arranged at the lower output section (200), and the output section (200) is arc-shaped.
3. The microfluidic chip for a drug delivery system according to claim 1, wherein: the outer side of the chip body (7) is provided with a first luer connector (1), a second luer connector (2) and a liquid outlet column (3).
4. A microfluidic chip for a drug delivery system according to claim 3, wherein: the liquid inlet pipe wall of the first luer connector (1) is communicated with the section A above the flow channel (4), and the liquid inlet pipe wall of the second luer connector (2) is communicated with the section B above the flow channel (4); after the two liquids are fully mixed, the two liquids flow out of the liquid outlet column (3).
5. A microfluidic chip for a drug delivery system according to claim 2, wherein: after two liquids are contacted, the two liquids enter the first flow dividing device on the output section (200), mixed liquid is separated at the flow dividing part (100) of the first flow dividing device, and then the two liquids are mixed again after passing through the annular flow passage, and enter the second flow dividing device, the third flow dividing device and the fourth flow dividing device in sequence in the same mode.
6. A microfluidic chip for a drug delivery system according to claim 3, wherein: luer external threads (5) are arranged on the outer sides of ports of the first luer connector (1) and the second luer connector (2), and the luer external threads (5) are used for being connected with a syringe.
7. The microfluidic chip for a drug delivery system according to claim 1, wherein: and the oblique flushing liquid inlet angles of the section A and the section B in the flow channel (4) are B.
8. The microfluidic chip for a drug delivery system according to claim 1, wherein: and an included angle a is formed between the flow passages of each three flow dividing devices (300) for buffering.
9. The microfluidic chip for a drug delivery system according to claim 1, wherein: grooves (6) are formed in two sides of the chip body (7).
10. A microfluidic chip for a drug delivery system according to claim 3, wherein: by controlling the injection speed of the injector, the liquid is made to enter the first luer connector (1) and the second luer connector (2) at different speeds, so that samples with different particle sizes are prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210821014.4A CN115999658A (en) | 2022-07-12 | 2022-07-12 | Microfluidic chip for drug delivery system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210821014.4A CN115999658A (en) | 2022-07-12 | 2022-07-12 | Microfluidic chip for drug delivery system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115999658A true CN115999658A (en) | 2023-04-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210821014.4A Pending CN115999658A (en) | 2022-07-12 | 2022-07-12 | Microfluidic chip for drug delivery system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115999658A (en) |
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2022
- 2022-07-12 CN CN202210821014.4A patent/CN115999658A/en active Pending
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