CN115990040A - Cervical brush for detecting E7 protein in home and detection method thereof - Google Patents
Cervical brush for detecting E7 protein in home and detection method thereof Download PDFInfo
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- CN115990040A CN115990040A CN202211475665.9A CN202211475665A CN115990040A CN 115990040 A CN115990040 A CN 115990040A CN 202211475665 A CN202211475665 A CN 202211475665A CN 115990040 A CN115990040 A CN 115990040A
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- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 21
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 21
- 238000001514 detection method Methods 0.000 title claims abstract description 20
- 238000005070 sampling Methods 0.000 claims abstract description 110
- 238000000034 method Methods 0.000 claims abstract description 6
- 210000001215 vagina Anatomy 0.000 claims description 26
- 239000003795 chemical substances by application Substances 0.000 claims description 17
- 210000003097 mucus Anatomy 0.000 claims description 13
- 238000001179 sorption measurement Methods 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 6
- 230000008014 freezing Effects 0.000 claims description 6
- 238000007710 freezing Methods 0.000 claims description 6
- 239000011521 glass Substances 0.000 claims description 5
- 230000002441 reversible effect Effects 0.000 claims description 5
- 238000007790 scraping Methods 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 241000973497 Siphonognathus argyrophanes Species 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 230000002829 reductive effect Effects 0.000 claims description 2
- 239000004576 sand Substances 0.000 claims 1
- 238000001125 extrusion Methods 0.000 abstract description 5
- 238000007689 inspection Methods 0.000 abstract description 5
- 238000007789 sealing Methods 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 description 7
- 238000010586 diagram Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 210000002919 epithelial cell Anatomy 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 201000000582 Retinoblastoma Diseases 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
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- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrology & Water Resources (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention provides an E7 protein self-home detection cervical brush and an inspection method thereof, wherein a swinging component comprises a rotating shaft, a baffle, a sleeve, a telescopic rod, a piston cylinder, a deformation layer and a raised strip, the rotating shaft is hinged to the inner wall of a sampling brush, which is close to one end of a brush head, the baffle swings to one side of the rotating shaft, the sleeve is inlaid at one end of the baffle, the telescopic rod is slidingly inlaid at one end of the sleeve, which is far away from the baffle, the piston rod is slidingly inlaid at the inner wall of one end of the sleeve, the deformation layer is inlaid at one end of the telescopic rod, the piston cylinder is inlaid at one end of the deformation layer, the raised strip is arranged at two sides of the deformation layer, at the moment, due to the inclination of the baffle, an interval is generated between the baffle and the brush head, the brush head can retract back to the inside of the sampling brush, one end of the baffle loses extrusion support, the baffle can return through the rotating shaft, the baffle can form reseal for the brush head, and the swinging component can form sealing again for the brush head after the brush head samples.
Description
Technical Field
The invention relates to the field of medical detection instruments, in particular to a cervical brush for detecting E7 protein in home and a detection method thereof.
Background
The E7 protein is an important cause of cervical epithelial cell diseases, cells can be proliferated infinitely by inhibiting retinoblastoma cell proteins, when the genome is destroyed and the functions of the cells are lost, the E7 protein starts to be expressed, the over-expression of the E7 protein is closely related to the risk of the cervical epithelial cell diseases, a self-sampling cervical brush is required to be used for the self-home detection of the E7 protein, a sample of the exfoliated cells is taken at the cervical orifice, and the E7 protein in the exfoliated cells of the cervix is detected, so that the cervical epithelial cell diseases can be diagnosed, and the technical teaching of the cervical brush is aimed at;
the study of cervical brushes found the following problems:
the cervical brush scrapes the tissue mucus on the cervical orifice through the brush head, the brush head firstly needs to enter the vagina of a human body before entering the cervical of the human body, at the moment, the surface of the brush head is easy to adhere part of the tissue mucus in the vagina, and meanwhile, when the brush head is taken out after scraping the cervical orifice mucus, the surface of the brush head is also easy to adhere part of the mucus, so that the detection result is easy to deviate after the cervical brush is sampled, and the brush head is easy to adhere to the cervical orifice mucus and the internal mucus of the vagina simultaneously;
at present, CN201810304181.5 in the prior art, a cervical brush with an improved structure, discloses a cervical brush, and after cell sampling is completed, one mounting frame is detached from a mounting rod, so that the separation of two groups of bristle parts can be realized, one-time sampling can be satisfied for cervical liquid-based cell smear inspection and HPV-DNA detection, and the rod body part is operated when the cervical brush is integrally used, so that the bristle parts are not touched, and the cervical brush is relatively sanitary;
the invention mainly solves the problem that cervical brush head is easy to adhere cervical mucous and vaginal mucous.
Disclosure of Invention
The invention aims to provide a cervical brush for detecting E7 protein in a home environment and a detection method thereof.
In order to achieve the above purpose, the present invention provides the following technical solutions:
a cervical brush for detecting E7 protein in house and its detecting method include sampling brush,
the inside slip of this sampling brush is run through there is the push rod, the one end of push rod is provided with the brush head, and it uses with the cooperation of cervical brush lid, the brush head is encircleed to the outside of push rod extension end has the ring.
As a further scheme of the invention: the inside of sampling brush is hollow form setting, and the push rod runs through to the outside of sampling brush, and the brush head is through the inside slip nestification of push rod and sampling brush, and the one end that the sampling brush is close to the brush head is equipped with anti-adhesion's swing subassembly.
As a further scheme of the invention: when the cervical brush cover is positioned at the outer side of the sampling brush, the cervical brush cover surrounds the outer side of the brush head, the brush head samples the cervical, and the brush head is connected with the push rod in a clamping manner.
As a further scheme of the invention: the side surface of the circular ring is in an isosceles trapezoid shape, one end of the maximum diameter of the circular ring is smaller than the diameter of the push rod by 0.5 cm to 1cm, and the circular ring and the swinging assembly are in the same horizontal plane.
As a further scheme of the invention: the swing assembly comprises a rotating shaft, a baffle, a sleeve, a telescopic rod, a piston cylinder, a deformation layer and a raised line, wherein the rotating shaft is hinged to the inner wall of the sampling brush, which is close to one end of the brush head, the baffle swings on one side of the rotating shaft, the sleeve is inlaid at one end of the baffle, the telescopic rod is slidingly nested at one end of the sleeve, which is far away from the baffle, the piston rod is slidingly arranged on the inner wall of one end of the sleeve, the deformation layer is inlaid at one end of the telescopic rod, which is close to the sleeve, the piston cylinder is inlaid at one end of the deformation layer, and the raised line is arranged on two sides of the deformation layer.
As a further scheme of the invention: the baffle is in a semicircular disc shape, the rotating shaft and the baffle are distributed on two sides of one end of the sampling brush in a matched mode, and the baffle swings at an angle of 5-35 degrees through the rotating shaft.
As a further scheme of the invention: the inner wall of sampling brush is located to the one end of telescopic link, and telescopic link and sleeve all are half circular arc form setting, and half circular arc angle is 45-90, and telescopic inside is hollow form setting, and the baffle is slip nested with telescopic link when the telescopic one end is swung.
As a further scheme of the invention: the piston rod is in a T-shaped arrangement, one end of the piston rod slidingly extends to the inside of the piston cylinder, the outer side of the piston rod is in sliding fit with the inner wall of the piston cylinder, and the piston rod and the sleeve are in linkage relation.
As a further scheme of the invention: the piston cylinder is in a cylindrical shape, one end of the piston cylinder, which is close to the deformation layer, is provided with a hole, the diameter of the hole is 2-4cm, and one end of the piston cylinder, which is close to the deformation layer, is in point-to-point connection with the deformation layer.
As a further scheme of the invention: the inner wall of the sleeve is provided with a groove matched with the convex strips, the thickness of the deformation layer is 0.2-0.4cm, the deformation layer is in point-to-point connection with one end of the telescopic rod, and the deformation layer is made of rubber or silica gel.
As a further scheme of the invention: one end of the brush head is slidably nested with a test tube, and one end of the test tube is rotatably sleeved with a tube cover.
As a further scheme of the invention: the test tube is the reagent tube, and the inside of test tube fills sample release agent, and the lower extreme of test tube is equipped with the collet, and test tube and tube cover are supplementary inspection tool, and the brush head sample is accomplished the back, and the brush head is embedded in the inside of test tube.
As a further scheme of the invention: the checking method comprises the following specific operation steps:
s1: the sampling brush and the push rod synchronously enter the human vagina, when the brush head is positioned in the sampling brush, one end of the baffle is attached to and sealed with one end of the brush head, so that the phenomenon that when the sampling brush enters the human vagina, one end of the brush head is adhered to the mucus in the vagina, one end of the push rod is manually pushed, the push rod drives the brush head to slide and extend to the outer side of the sampling brush, and the brush head is extruded to one end of the baffle;
s2: the ring extends to the outer side of the sampling brush synchronously, the baffle swings towards one end far away from the sampling brush through the rotating shaft, the sleeve is driven to swing synchronously when the baffle swings, the sleeve can drive the piston rod to slide in the piston cylinder, and as the outer side of the piston rod is in sliding fit with the inner wall of the piston cylinder, when the piston rod slides towards one end far away from the telescopic rod, the external force forces the volume of air in the piston cylinder to become larger, so that the pressure in the piston cylinder becomes smaller, a pressure difference is formed between the air cylinder and the external atmospheric pressure, and the piston rod can extract the side face of the deformation layer by utilizing the pressure difference;
s3: one end of the deformation layer is deformed and extends into the hole of the piston cylinder, the raised strips and the inner wall of the sleeve are separated, the sleeve can slide outside the telescopic rod conveniently, and meanwhile, the cervical orifice of a human body can be sampled through the brush head;
s4: after sampling is completed, the push rod is reversely pulled, the push rod drives the brush head and the circular ring to slide into the sampling brush, the circular ring is extruded to one end of the baffle before returning to the inside of the sampling brush, the baffle swings towards the inside of the sampling brush through the rotating shaft, the baffle assists the piston rod to return and slide through the sleeve, at the moment, the piston rod can assist the deformation layer to return through reverse operation, and the convex strips on two sides of the deformation layer can be nested with the grooves on the inner wall of the sleeve;
s5: after the sleeve is reset and slides to one end, the raised strips on the two sides of the deformation layer can be nested with the grooves on the inner wall of the sleeve and cannot continuously slide, at the moment, due to the inclination of the baffle, an interval is formed between the baffle and the brush head, the brush head can retract to the inside of the sampling brush again, after the brush head returns, one end of the baffle loses extrusion support, the baffle can return through the rotating shaft, and the baffle can form resealing for the brush head;
s6: after sampling, lightly inverting the test tube filled with the sample releasing agent for three times, adsorbing the bottom support at the lower end of the test tube on a glass surface or a plane with better adsorption force, determining that the test tube and the bottom support are firmly adsorbed, and then performing the next step to avoid tilting the test tube under the condition that the adsorption is not firm, sprinkling the sample releasing agent, holding the test tube by one hand, lightly unscrewing the tube cover by the other hand, ensuring that the mouth of the test tube and the mouth of the tube cover are upward, then inserting a sampling brush into the test tube, lightly pressing down and placing the test tube in place;
s7: then fixing the sampling brush by one hand, slightly pushing the push rod by the other hand, driving the brush head to be immersed in the sample releasing agent by the push rod, rotating for 10 circles after the brush head contacts the bottom of the test tube, fully scraping the brush head and the bottom of the test tube, disconnecting the push rod from the brush head by one hand, leaving the brush head in the test tube, and lightly screwing the tube cover;
s8: and vertically putting the test tube into a freezing refrigerator to freeze for 30min plus or minus 5min, taking out the test tube from the refrigerator, standing at room temperature, standing, dissolving, standing on a horizontal table top again for 20-30 min for later use, and using the treated sample within 2 h.
Advantageous effects
1. According to the invention, the sampling brush and the push rod synchronously enter the human vagina, when the brush head is positioned in the sampling brush, one end of the baffle is in fit and seal with one end of the brush head, so that when the sampling brush enters the human vagina, one end of the brush head is adhered to the internal mucus of the vagina, one end of the push rod is manually pushed, the push rod drives the brush head to slide and extend to the outer side of the sampling brush, the brush head is extruded to one end of the baffle, the ring synchronously extends to the outer side of the sampling brush, the baffle swings towards one end far away from the sampling brush through the rotating shaft, the sleeve is driven to synchronously swing when the baffle swings, the sleeve can drive the piston rod to slide in the piston cylinder, and as the outer side of the piston rod is in fit with the inner wall of the piston cylinder in a sliding manner, the piston rod is forced to enlarge the volume of air in the piston cylinder when the piston rod slides towards one end far away from the telescopic rod, so that the pressure difference is formed between the pressure in the piston cylinder and the external atmospheric pressure, the piston rod can extract the side of the deformation layer by using the pressure difference, and at the moment, one end of the deformation layer is deformed and extends to the hole of the piston cylinder, the inner wall of the sleeve is separated, the convex strip and the inner wall of the sleeve is convenient for the sleeve to slide towards the outer side of the telescopic rod, and the human cervical opening can be sampled at the same time;
2. after the sampling is finished, the push rod is reversely pulled, the push rod drives the brush head and the circular ring to slide into the sampling brush, the outer side wall of the circular ring is extruded to one end of the baffle before the circular ring returns into the sampling brush, the baffle swings towards the inside of the sampling brush through the rotating shaft, the baffle assists the piston rod to return and slide through the sleeve, at the moment, the piston rod can assist the deformation layer to return through reverse operation, and the convex strips on two sides of the deformation layer can be nested with the grooves on the inner wall of the sleeve;
3. according to the invention, after the sleeve is reset and slides for a certain distance, the raised strips on the two sides of the deformation layer can be nested with the grooves on the inner wall of the sleeve and cannot continuously slide, at the moment, due to the inclination of the baffle, the baffle and the brush head generate a space, the brush head can retract again to the inside of the sampling brush, after the brush head is reset, one end of the baffle loses extrusion support, the baffle can return through the rotating shaft, the baffle can form resealing on the brush head, so that the swinging assembly can form sealing on the brush head again after the brush head is sampled, and the mucous in the human vagina is prevented from adhering to the inside of the brush head when the human vagina is taken out;
4. after the sample is taken, the test tube with the sample releasing agent is gently turned upside down for three times, the bottom support at the lower end of the test tube is adsorbed on a glass surface or a plane with better adsorption force, the test tube and the bottom support are firmly adsorbed, and then the next step is carried out, so that the problem that the test tube is inclined under the condition that the adsorption is not firm is avoided, the sample releasing agent is sprayed out, then the test tube is held by one hand, the tube cover is gently unscrewed by the other hand, the mouth of the test tube and the mouth of the tube cover are both upward, then a sampling brush is inserted into the test tube, and the test tube is gently pressed down and placed in place.
Drawings
Fig. 1 is a schematic diagram of the overall structure of the present invention.
FIG. 2 is a schematic diagram of a sampling structure according to the present invention.
Fig. 3 is a partial schematic view of a sampling brush according to the present invention.
Fig. 4 is a schematic partial cross-sectional view of a sampling brush of the present invention.
Fig. 5 is an enlarged schematic view of fig. 4 a in accordance with the present invention.
Fig. 6 is a schematic diagram of a swing section of a baffle plate of the present invention.
Fig. 7 is a schematic cross-sectional view of a sleeve according to the present invention.
Fig. 8 is a schematic view of the brush head and test tube structure of the present invention.
FIG. 9 is a schematic view of the structure of the test tube of the present invention.
Fig. 10 is a schematic diagram of deformation of the deformation layer according to the present invention.
In fig. 1-10: 1-sampling brush, 101-push rod, 102-cervical brush cover, 103-brush head, 104-circular ring, 2-rotating shaft, 201-baffle, 3-sleeve, 301-telescopic rod, 302-piston rod, 4-piston cylinder, 401-deformation layer, 402-convex strip, 5-test tube and 501-tube cover.
Detailed Description
Referring to fig. 1-10, in an embodiment of the present invention,
example 1: the utility model provides a cervical brush for E7 albumen self-contained home detection and inspection method thereof, includes that the inside slip of this sampling brush 1 runs through and has push rod 101, the one end of push rod 101 is provided with brush head 103, and it cooperates with cervical brush cover 102 to use brush head 103 to the outside ring 104 that extends of push rod 101.
Wherein: the inside of the sampling brush 1 is hollow, the push rod 101 penetrates to the outer side of the sampling brush 1, the brush head 103 is nested with the inside of the sampling brush 1 in a sliding way through the push rod 101, and an anti-adhesion swinging assembly is arranged at one end, close to the brush head 103, of the sampling brush 1;
the side surface of the circular ring 104 is isosceles trapezoid, one end of the maximum diameter of the circular ring 104 is smaller than the diameter of the push rod 101 by 0.5 cm to 1cm, and the circular ring 104 and the swinging component are arranged on the same horizontal plane;
one end of the largest diameter of the circular ring 104 is smaller than the diameter of the push rod 101 by 0.5 cm to 1cm, so that the condition that the brush head 103 and the push rod 101 enter the vagina of a human body due to the fact that the diameter of the push rod 101 is large in the circular ring 104 is prevented;
example 2: referring to fig. 4-7 and 10 of the drawings, it can be seen that embodiment 2 is different from embodiment 1 in that the swing assembly comprises a rotating shaft 2, a baffle 201, a sleeve 3, a telescopic rod 301, a piston rod 302, a piston cylinder 4, a deformation layer 401 and a raised strip 402, wherein the rotating shaft 2 is hinged to the inner wall of the sampling brush 1 near one end of the brush head 103, the baffle 201 swings on one side of the rotating shaft 2, the sleeve 3 is inlaid at one end of the baffle 201, the telescopic rod 301 is slidingly inlaid at one end of the sleeve 3 far from the baffle 201, the piston rod 302 is slidingly inlaid at the inner wall of one end of the sleeve 3, the deformation layer 401 is inlaid at one end of the telescopic rod 301 near the sleeve 3, the piston cylinder 4 is inlaid at one end of the deformation layer 401, and the raised strip 402 is arranged at two sides of the deformation layer 401;
wherein: the baffle 201 is arranged in a semicircular disc shape, the rotating shaft 2 and the baffle 201 are distributed on two sides of one end of the sampling brush 1 in a matched mode, and the baffle 201 swings at an angle of 5-35 degrees through the rotating shaft 2;
when the brush head 103 is positioned in the sampling brush 1, one end of the baffle 201 is in fit and seal with one end of the brush head 103, and the specific position refers to figure 5 of the specification, so that when the sampling brush 1 enters the vagina of a human body, one end of the brush head 103 can be prevented from adhering to the mucus in the vagina;
the device comprises a sleeve 3 and a telescopic rod 301, wherein one end of the telescopic rod 301 is arranged on the inner wall of the sampling brush 1, the telescopic rod 301 and the sleeve 3 are arranged in a semicircular arc shape, the semicircular arc angle is 45-90 degrees, the inside of the sleeve 3 is arranged in a hollow shape, and when the baffle 201 swings towards one end of the sleeve 3, the sleeve 3 and the telescopic rod 301 are nested in a sliding manner;
the piston rod 302, the piston rod 302 is arranged in a T shape, one end of the piston rod 302 extends into the piston cylinder 4 in a sliding way, the outer side of the piston rod 302 is in sliding fit with the inner wall of the piston cylinder 4, and the piston rod 302 and the sleeve 3 are in linkage relation;
when the baffle 201 swings, the sleeve 3 is driven to swing synchronously, the sleeve 3 can drive the piston rod 302 to slide in the piston cylinder 4, and as the outer side of the piston rod 302 is in sliding fit with the inner wall of the piston cylinder 4, when the piston rod 302 slides towards one end far away from the telescopic rod 301, the external force forces the volume of air in the piston cylinder 4 to become larger, so that the pressure in the piston cylinder 4 becomes smaller, and a pressure difference is formed between the external atmospheric pressure, the piston rod 302 can extract the side face of the deformation layer 401 by utilizing the pressure difference, at the moment, one end of the deformation layer 401 deforms and extends into a hole of the piston cylinder 4, and referring to fig. 10 of the specification, the specific principle can refer to the principle of extracting liquid medicine from a needle cylinder;
the piston cylinder 4 is arranged in a cylindrical shape, a hole is formed in one end, close to the deformation layer 401, of the piston cylinder 4, the diameter of the hole is 2-4cm, and one end, close to the deformation layer 401, of the piston cylinder 4 is in point-to-point connection with the deformation layer 401;
a hole is formed in one end, close to the deformation layer 401, of the piston cylinder 4, the diameter of the hole is 2-4cm, and inconvenience that the deformation layer 401 deforms and extends into the piston cylinder 4 due to the fact that the diameter of the hole is smaller than 2cm is avoided;
one end of the piston cylinder 4, which is close to the deformation layer 401, is connected with the deformation layer 401 in a point-to-point manner, so that the deformation layer 401 cannot deform at one end of the piston cylinder 4 after the piston cylinder 4 is attached to the deformation layer 401;
the inner wall of the sleeve 3 is provided with grooves matched with the convex strips 402, the convex strips 402 are in sliding nesting with the grooves, the thickness of the deformation layer 401 is 0.2-0.4cm, the deformation layer 401 is in point-to-point connection with one end of the telescopic rod 301, and the deformation layer 401 is made of rubber or silica gel;
the thickness of the deformation layer 401 is 0.2-0.4cm, so that the situation that the deformation layer 401 cannot deform when the thickness of the deformation layer 401 is larger than 0.4cm is avoided;
wherein: the sampling brush 1 and the push rod 101 synchronously enter the human vagina, when the brush head 103 is positioned in the sampling brush 1, one end of the baffle 201 is in fit and seal with one end of the brush head 103, so that when the sampling brush 1 enters the human vagina, one end of the brush head 103 is adhered to the internal mucus of the vagina, one end of the push rod 101 is manually pushed, the push rod 101 drives the brush head 103 to slide and extend to the outer side of the sampling brush 1, the brush head 103 is extruded to one end of the baffle 201, the circular ring 104 synchronously extends to the outer side of the sampling brush 1, the baffle 201 swings to one end far from the sampling brush 1 through the rotating shaft 2, the sleeve 3 is driven to synchronously swing when the baffle 201 swings, the sleeve 3 can drive the piston rod 302 to slide in the piston cylinder 4, and the outer side of the piston rod 302 is in fit with the inner wall of the piston cylinder 4 in a sliding manner, when the piston rod 302 slides to one end far from the telescopic rod 301, the external force is increased in the volume of the piston cylinder 4, the pressure of the piston cylinder 4 is reduced, a pressure difference is formed between the external atmospheric pressure, the piston rod 302 can extract the side of the deformation layer 401 by utilizing the pressure difference, one end of the deformation layer 401 extends to the inner side of the piston cylinder 4 to the piston cylinder 103, and the inner wall of the telescopic rod 3 can slide along the inner wall of the sleeve 3, and the inner wall of the sleeve 3 can slide along the inner wall of the sleeve opening of the sleeve 3, and the inner wall of the sleeve opening of the human vagina can be convenient, and the gap can slide hole 402 can slide along the inner wall of the sleeve 3;
after sampling is completed, the push rod 101 is reversely pulled, the push rod 101 drives the brush head 103 and the circular ring 104 to slide into the sampling brush 1, the circular ring 104 is extruded to one end of the baffle 201 before returning to the sampling brush 1, the baffle 201 swings towards the inside of the sampling brush 1 through the rotating shaft 2, the baffle 201 assists the piston rod 302 to return and slide through the sleeve 3, at the moment, the piston rod 302 can assist the deformation layer 401 to return through reverse operation, and the raised strips 402 on two sides of the deformation layer 401 can be nested with grooves on the inner wall of the sleeve 3, and reference can be made to fig. 7 of the specification;
therefore, after the sleeve 3 slides one end distance in a return manner, the convex strips 402 on two sides of the deformation layer 401 can be nested with the grooves on the inner wall of the sleeve 3 and cannot continuously slide, at this time, due to the inclination of the baffle 201, a space is generated between the baffle 201 and the brush head 103, the brush head 103 can retract into the sampling brush 1 again, after the brush head 103 returns, one end of the baffle 201 loses extrusion support, the baffle 201 can return through the rotating shaft 2, the baffle 201 can form resealing on the brush head 103, and further the swinging assembly can form sealing on the brush head 103 again after the brush head 103 samples, so that when the brush head 103 is taken out from the human vagina, mucus in the human vagina is prevented from adhering to the inside of the brush head 103;
example 3: as can be seen from fig. 8 and 9 of the specification, embodiment 3 is different from embodiments 1 and 2 in that a test tube 5 is slidably nested at one end of a brush head 103, and a tube cover 501 is rotatably nested at one end of the test tube 5;
wherein: the test tube 5 and the tube cover 501, the test tube 5 is a reagent tube, the sample releasing agent is filled in the test tube 5, the lower end of the test tube 5 is provided with a collet, the test tube 5 and the tube cover 501 are auxiliary inspection tools, and after the brush head 103 is sampled, the brush head 103 is embedded in the test tube 5;
wherein: after sampling, the test tube 5 containing the sample releasing agent is gently turned upside down for three times, the bottom support at the lower end of the test tube 5 is adsorbed on a glass surface or a plane with better adsorption force, after the fact that the test tube 5 and the bottom support are firmly adsorbed is determined, the next step is carried out, so that the test tube 5 is prevented from tilting under the condition that the adsorption is not firm, the sample releasing agent is sprayed out, then the test tube 5 is held by one hand, the tube cover 501 is gently unscrewed by the other hand, the mouth of the test tube mouth and the mouth of the tube cover 501 are both upward, then the sampling brush 1 is inserted into the test tube 5, and the test tube is gently pressed down and placed in place, and the test tube is specifically shown in the attached drawing 8 of the specification;
then fixing the sampling brush 1 by one hand, lightly pushing the push rod 101 by the other hand, driving the brush head 103 to be immersed in a sample releasing agent by the push rod 101, rotating for 10 circles after the brush head 103 contacts the bottom of the test tube 5, fully scraping the brush head 103 and the bottom of the test tube 5, disconnecting the push rod 101 from the brush head 103 by one hand, leaving the brush head 103 in the test tube 5, and lightly screwing the tube cover 501;
vertically placing the test tube 5 into a freezing refrigerator, freezing at about-20 ℃ for 30min plus or minus 5min, taking out from the refrigerator, standing at room temperature, standing, dissolving, standing on a horizontal table top again for 20-30 min for later use;
the treated sample was used within 2 hours;
example 4: the checking method comprises the following specific operation steps:
s1: the sampling brush 1 and the push rod 101 synchronously enter the vagina of a human body, when the brush head 103 is positioned in the sampling brush 1, one end of the baffle 201 is in fit and seal with one end of the brush head 103, so that the phenomenon that when the sampling brush 1 enters the vagina of the human body, one end of the brush head 103 is adhered to mucus in the vagina, one end of the push rod 101 is manually pushed, the push rod 101 drives the brush head 103 to slide and extend to the outer side of the sampling brush 1, and the brush head 103 is extruded to one end of the baffle 201;
s2: the ring 104 extends to the outer side of the sampling brush 1 synchronously, the baffle 201 swings towards one end far away from the sampling brush 1 through the rotating shaft 2, the sleeve 3 is driven to swing synchronously when the baffle 201 swings, the sleeve 3 can drive the piston rod 302 to slide in the piston cylinder 4, and as the outer side of the piston rod 302 is in sliding fit with the inner wall of the piston cylinder 4, when the piston rod 302 slides towards one end far away from the telescopic rod 301, the external force forces the volume of air in the piston cylinder 4 to become larger, so that the pressure in the piston cylinder 4 becomes smaller, a pressure difference is formed between the external atmospheric pressure and the pressure, and the piston rod 302 can extract the side face of the deformation layer 401 by utilizing the pressure difference;
s3: one end of the deformation layer 401 deforms and extends into the hole of the piston cylinder 4, the convex strips 402 and the inner wall of the sleeve 3 generate intervals, the sleeve 3 can conveniently slide outside the telescopic rod 301, and meanwhile, the cervical orifice of a human body can be sampled through the brush head 103;
s4: after sampling is completed, the push rod 101 is reversely pulled, the push rod 101 drives the brush head 103 and the circular ring 104 to slide into the sampling brush 1, the circular ring 104 is extruded to one end of the baffle 201 before returning to the sampling brush 1, the baffle 201 swings towards the inside of the sampling brush 1 through the rotating shaft 2, the baffle 201 assists the piston rod 302 to return and slide through the sleeve 3, at the moment, the piston rod 302 can assist the deformation layer 401 to return through reverse operation, and the raised strips 402 on two sides of the deformation layer 401 can be nested with grooves on the inner wall of the sleeve 3;
s5: after the sleeve 3 returns to one end and slides, the convex strips 402 on the two sides of the deformation layer 401 can be nested with the grooves on the inner wall of the sleeve 3 and cannot continuously slide, at the moment, due to the inclination of the baffle 201, a space is generated between the baffle 201 and the brush head 103, the brush head 103 can retract into the sampling brush 1 again, after the brush head 103 returns, one end of the baffle 201 loses extrusion support, the baffle 201 can return through the rotating shaft 2, and the baffle 201 can form resealing on the brush head 103;
s6: after sampling, the test tube 5 containing the sample releasing agent is gently turned upside down for three times, the bottom support of the lower end of the test tube 5 is adsorbed on a glass surface or a plane with better adsorption force, after the fact that the test tube 5 and the bottom support are firmly adsorbed is determined, the next step is carried out, so that the inclination of the test tube 5 is avoided under the condition that the adsorption is not firm, the sample releasing agent is sprayed out, then the test tube 5 is held by one hand, the tube cover 501 is gently unscrewed by the other hand, the mouth of the test tube mouth and the mouth of the tube cover 501 are both upward, then the sampling brush 1 is inserted into the test tube 5, and the test tube is gently pressed down and placed in place;
s7: then fixing the sampling brush 1 by one hand, lightly pushing the push rod 101 by the other hand, driving the brush head 103 to be immersed in a sample releasing agent by the push rod 101, rotating for 10 circles after the brush head 103 contacts the bottom of the test tube 5, fully scraping the brush head 103 and the bottom of the test tube 5, disconnecting the push rod 101 from the brush head 103 by one hand, leaving the brush head 103 in the test tube 5, and lightly screwing the tube cover 501;
s8: and vertically placing the test tube 5 into a freezing refrigerator, freezing at about minus 20 ℃ for 30min plus or minus 5min, taking out from the refrigerator, standing at room temperature, standing, dissolving, standing on a horizontal table top again for 20-30 min for later use, and using the treated sample within 2 hours.
The foregoing is merely a preferred embodiment of the present invention, and it should be noted that modifications and improvements can be made by those skilled in the art without departing from the spirit of the present invention, and these should also be considered as the scope of the present invention, which does not affect the effect of the implementation of the present invention and the utility of the patent.
Claims (10)
1. The utility model provides an E7 albumen is detection of house with cervical brush, includes sampling brush (1), its characterized in that: the inside slip of this sampling brush (1) is run through there is push rod (101), the one end of push rod (101) is provided with brush head (103), and it is used with cervical brush lid (102) cooperation, brush head (103) are encircleed to the one end outside that push rod (101) extends and are had ring (104).
2. The cervical brush for home detection of E7 protein according to claim 1, wherein: the inside of the sampling brush (1) is arranged in a hollow shape, the push rod (101) penetrates through the outside of the sampling brush (1), the brush head (103) is nested with the inside of the sampling brush (1) in a sliding manner through the push rod (101), and an anti-adhesion swinging assembly is arranged at one end, close to the brush head (103), of the sampling brush (1);
when the cervical brush cover (102) is positioned at the outer side of the sampling brush (1), the cervical brush cover (102) surrounds the outer side of the brush head (103), the brush head (103) samples the cervical, and the brush head (103) is in buckling connection with the push rod (101);
the side of the circular ring (104) is in an isosceles trapezoid shape, one end of the maximum diameter of the circular ring (104) is smaller than the diameter of the push rod (101) by 0.5 cm to 1cm, and the circular ring (104) and the swing assembly are arranged on the same horizontal plane.
3. The cervical brush for home detection of E7 protein according to claim 2, wherein: the swing assembly includes: a rotating shaft (2), a baffle plate (201), a sleeve (3), a telescopic rod (301), a piston rod (302), a piston cylinder (4), a deformation layer (401) and a convex strip (402);
the utility model provides a sampling brush, including brush head (103) and baffle (201), pivot (2) are articulated in the inner wall that brush head (103) one end is close to in sampling brush (1), baffle (201) set up in one side of pivot (2), sleeve (3) are inlayed in the one end of baffle (201), telescopic link (301) slip nest is kept away from the one end of baffle (201) in sleeve (3), piston rod (302) slip in the inner wall of sleeve (3) one end, deformation layer (401) are inlayed in telescopic link (301) and are close to the one end of sleeve (3), piston cylinder (4) are inlayed in the one end of deformation layer (401), both sides of deformation layer (401) are located to sand grip (402).
4. A cervical brush for home detection of E7 protein as defined in claim 3, wherein: the baffle (201) is arranged in a semicircular disc shape, the rotating shaft (2) and the baffle (201) are distributed on two sides of one end of the sampling brush (1) in a matched mode, and the baffle (201) swings at an angle of 5-35 degrees through the rotating shaft (2);
the inner wall of sampling brush (1) is located to one end of telescopic link (301), and telescopic link (301) and telescopic link (3) are all in the semicircle form setting, and semicircle angle is 45-90, the inside of telescopic link (3) is the cavity form setting, and when baffle (201) were swung to the one end of telescopic link (3), sleeve (3) were slip nestification with telescopic link (301).
5. A cervical brush for home detection of E7 protein as defined in claim 3, wherein: the piston rod (302) is arranged in a T shape, one end of the piston rod (302) slides and extends to the inside of the piston cylinder (4), the outer side of the piston rod (302) is in sliding fit with the inner wall of the piston cylinder (4), and the piston rod (302) is in linkage connection with the sleeve (3).
6. A cervical brush for home detection of E7 protein as defined in claim 3, wherein: the inner wall of the sleeve (3) is provided with a groove matched with the raised strips (402), the thickness of the deformation layer (401) is 0.2-0.4cm, the deformation layer (401) is connected with one end point of the telescopic rod (301), and the deformation layer (401) is made of rubber or silica gel.
7. A cervical brush for home detection of E7 protein as defined in claim 3, wherein: the piston cylinder (4) is in a cylindrical shape, a hole with the diameter of 2-4cm is formed in one end, close to the deformation layer (401), of the piston cylinder (4), and one end, close to the deformation layer (401), of the piston cylinder (4) is in point connection with the deformation layer (401).
8. The cervical brush for home detection of E7 protein according to claim 1, wherein: one end of the brush head (103) is slidably nested with a test tube (5), and one end of the test tube (5) is rotatably sleeved with a tube cover (501).
9. The cervical brush for home detection of E7 protein as defined in claim 8, wherein: the inside of test tube (5) is filled with sample release agent, the lower extreme of test tube (5) is equipped with the collet, waits after brush head (103) sampling is accomplished, and brush head (103) imbeds in the inside of test tube (5).
10. The examination method of a cervical brush for home detection of E7 protein according to any one of claims 1 to 9, comprising the steps of:
s1: when the sampling brush (1) and the push rod (101) enter the vagina of a human body, the brush head (103) is positioned in the sampling brush (1), one end of the baffle (201) is in fit and seal with one end of the brush head (103), so that when the sampling brush (1) enters the vagina of the human body, one end of the brush head (103) is prevented from adhering to the mucus in the vagina, one end of the push rod (101) is manually pushed, the push rod (101) drives the brush head (103) to slide and extend to the outer side of the sampling brush (1), and the brush head (103) is extruded to one end of the baffle (201);
s2: the ring (104) extends to the outer side of the sampling brush (1), the baffle (201) swings towards one end far away from the sampling brush (1) through the rotating shaft (2), the sleeve (3) is driven to synchronously swing when the baffle (201) swings, the sleeve (3) drives the piston rod (302) to slide in the piston cylinder (4), the outer side of the piston rod (302) is in sliding fit with the inner wall of the piston cylinder (4), when the piston rod (302) slides towards one end far away from the telescopic rod (301), the external force forces the volume of air in the piston cylinder (4) to be increased, so that the pressure in the piston cylinder (4) is reduced, a pressure difference is formed between the external atmospheric pressure and the piston rod (302) extracts the side face of the deformation layer (401) by using the pressure difference;
s3: one end of the deformation layer (401) deforms and extends into a hole of the piston cylinder (4), the convex strips (402) are spaced from the inner wall of the sleeve (3), the sleeve (3) slides outside the telescopic rod (301), and the cervical orifice of a human body is sampled through the brush head (103);
s4: after sampling is completed, the push rod (101) is reversely pulled, the push rod (101) drives the brush head (103) and the circular ring (104) to slide into the sampling brush (1), the circular ring (104) is extruded to one end of the baffle plate (201) before returning to the inside of the sampling brush (1), the baffle plate (201) swings towards the inside of the sampling brush (1) through the rotating shaft (2), the baffle plate (201) assists the piston rod (302) to return and slide through the sleeve (3), the piston rod (302) can assist the deformation layer (401) to return through reverse operation, and the convex strips (402) on two sides of the deformation layer (401) are nested with grooves on the inner wall of the sleeve (3);
s5: after the sleeve (3) returns to one end to slide, convex strips (402) on two sides of the deformation layer (401) are nested with grooves on the inner wall of the sleeve (3), the brush head (103) is retracted into the sampling brush (1) again, after the brush head (103) returns, the baffle (201) returns through the rotating shaft (2), and the baffle (201) seals the brush head (103) again;
s6: after sampling, lightly inverting the test tube (5) filled with the sample releasing agent for three times, adsorbing the bottom bracket of the test tube (5) on a glass surface or a plane with good adsorption force, so that the test tube (5) is inclined, the sample releasing agent is sprayed out, holding the test tube (5) by one hand, slightly unscrewing the tube cover (501) by the other hand, leading the mouth of the test tube mouth and the mouth of the tube cover (501) to be upward, inserting the sampling brush (1) into the test tube (5), slightly pressing down with force, and placing in place;
s7: then fixing the sampling brush (1) by one hand, slightly pushing the push rod (101) by the other hand, driving the brush head (103) to be immersed in the sample releasing agent by the push rod (101), rotating for 10 circles after the brush head (103) contacts the bottom of the test tube (5), fully scraping the brush head (103) and the bottom of the test tube (5), disconnecting the push rod (101) and the brush head (103) by one hand, retaining the brush head (103) in the test tube (5), and lightly screwing the tube cover (501);
s8: and vertically placing the test tube (5) into a freezing refrigerator to freeze for 30min plus or minus 5min, taking out from the refrigerator, standing at room temperature, standing for dissolving, standing on a horizontal table top again for 20-30 min for later use, and using the treated sample within 2 h.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211475665.9A CN115990040B (en) | 2022-11-23 | 2022-11-23 | Cervical brush for detecting E7 protein in home and detection method thereof |
| PCT/CN2022/141221 WO2024108713A1 (en) | 2022-11-23 | 2022-12-23 | Cervical swab for household e7 protein testing and testing method thereof |
| ZA2023/04987A ZA202304987B (en) | 2022-11-23 | 2023-05-05 | E7 protein self-home detection cervical brush and inspection method therefor |
| JP2023096521A JP2024075546A (en) | 2022-11-23 | 2023-06-12 | Cervical brush for automated home testing of E7 protein and method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211475665.9A CN115990040B (en) | 2022-11-23 | 2022-11-23 | Cervical brush for detecting E7 protein in home and detection method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115990040A true CN115990040A (en) | 2023-04-21 |
| CN115990040B CN115990040B (en) | 2024-07-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202211475665.9A Active CN115990040B (en) | 2022-11-23 | 2022-11-23 | Cervical brush for detecting E7 protein in home and detection method thereof |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2024075546A (en) |
| CN (1) | CN115990040B (en) |
| WO (1) | WO2024108713A1 (en) |
| ZA (1) | ZA202304987B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117643484A (en) * | 2024-01-25 | 2024-03-05 | 湖南莱博赛医用机器人有限公司 | Cervical cancer detection device and intelligent detection screening method |
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Also Published As
| Publication number | Publication date |
|---|---|
| ZA202304987B (en) | 2023-11-29 |
| WO2024108713A1 (en) | 2024-05-30 |
| JP2024075546A (en) | 2024-06-04 |
| CN115990040B (en) | 2024-07-23 |
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