CN115969909B - Traditional Chinese medicine composition and fermented traditional Chinese medicine preparation for improving sub-health of sow as well as preparation method and application of traditional Chinese medicine composition and fermented traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine composition and fermented traditional Chinese medicine preparation for improving sub-health of sow as well as preparation method and application of traditional Chinese medicine composition and fermented traditional Chinese medicine preparation Download PDFInfo
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of fermented traditional Chinese medicine preparations for animals, and particularly relates to a traditional Chinese medicine composition for improving sub-health of sows, a fermented traditional Chinese medicine preparation, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-30 parts of silybum marianum, 20-30 parts of polygonum cuspidatum, 20-30 parts of water chestnut, 10-15 parts of honeysuckle, 5-10 parts of white paeony root, 5-10 parts of gynostemma pentaphylla, 10-15 parts of liquorice, 1-5 parts of radix codonopsis, 5-10 parts of bighead atractylodes rhizome, 5-10 parts of angelica sinensis, 1-5 parts of red sage root, 1-5 parts of astragalus membranaceus, 1-5 parts of eclipta, 1-5 parts of radix bupleuri, 1-5 parts of poria cocos, 1-5 parts of dried orange peel, 1-5 parts of fried hawthorn and 1-5 parts of organic yeast selenium. The traditional Chinese medicine composition and the fermented traditional Chinese medicine preparation can comprehensively improve the sub-health state of sows, improve the health degree of sows, improve the breeding rate of the replacement sows, obviously reduce the two-embryo syndrome of the sows, eliminate the tear spot swelling of the multiperiod sows, restore the skin to be light red, eliminate the sub-health state of the sows, restore the oestrus and the breeding of the sows to be normal, and reduce the elimination rate of the sows.
Description
Technical Field
The invention belongs to the technical field of fermented traditional Chinese medicine preparations for animals, and particularly relates to a traditional Chinese medicine composition for improving sub-health of sows, a fermented traditional Chinese medicine preparation, a preparation method and application thereof.
Background
The sow is the core of pig farm cultivation, the disease resistance and the stress resistance of piglets are closely related to the sow, the health state of the sow is directly related to the exertion of the production performance and influences the production benefit of the pig farm, and particularly, the large-scale and intensive cultivation mode in modern animal husbandry cultivation brings higher requirements to the health level of the sow at a high-strength production rhythm. However, sows may be disturbed by the internal and external environments during growth, and once these toxins cannot be cleared in the pig body in time, the pig herd will release "sub-health signals", i.e. tear spots, old skin, swelling of the vulva, oestrus, dysplasia of the mammary glands, reduced levels of vaccine antibodies, etc. occur. Health care for sub-health state of sows has become the core of each big pig farm, but the side effects that traditional antibiotic health care causes the decrease of the physique of sows, the decrease of reproductive production performance and the like have been increasingly questioned by industry people. Therefore, a green pollution-free drug capable of replacing antibiotics is needed to improve the sub-health condition of sows and improve the productivity of the sows.
In recent years, the anti-aging and anti-subtracting call for the raising industry is higher and higher, and the veterinary drug has the advantages of remarkable control effect, relatively small toxic and side effects on livestock and poultry, no harmful residues in animal foods and difficult drug resistance generation, and the development of veterinary drug products and feed additives is attracting attention increasingly at present, which is sensitive to food safety problems. The application of the traditional Chinese veterinary medicine is used for satisfying the objective requirement of livestock breeding, reflecting the viewpoint of' no disease prevention in the traditional Chinese medicine control system, leading the traditional Chinese veterinary medicine to participate in animal epidemic disease prevention, anti-stress and antibacterial, fully regulating the nonspecific immunity of animal organisms, coordinating the physiological functions of the organisms and improving the disease prevention capability of the organisms.
The fermentation technology has thousands of years history in China, but the traditional Chinese medicine prepared by fermentation is not very much, the reasons for the traditional Chinese medicine are greatly related to the screening and culture of microorganism varieties and the traditional Chinese medicine variety suitable for fermentation, the traditional Chinese medicine fermentation technology has lower efficiency, and the requirement of industrial production is difficult to meet. In recent years, with the development of microecology, modern bioengineering technology is increasingly applied to the field of traditional Chinese medicines, especially fermentation technology. The traditional Chinese medicine can improve the performance of the medicine after fermentation, generate new medicine effect and provide basis for the development of new medicine sources.
In view of this, the present inventors have developed a traditional Chinese medicine composition and a fermented traditional Chinese medicine preparation capable of improving sub-health status of sow in combination with the technical field of veterinary drug preparation.
Disclosure of Invention
In order to solve the technical problems, the invention provides a traditional Chinese medicine composition and a fermented traditional Chinese medicine preparation for improving sub-health of sows, and a preparation method and application thereof.
Specifically, the invention is realized through the following technical schemes:
in a first aspect, the invention provides a traditional Chinese medicine composition for improving sub-health of a sow, which is prepared from the following raw materials in parts by weight: 20-30 parts of silybum marianum, 20-30 parts of polygonum cuspidatum, 20-30 parts of water chestnut, 10-15 parts of honeysuckle, 5-10 parts of white paeony root, 5-10 parts of gynostemma pentaphylla, 10-15 parts of liquorice, 1-5 parts of radix codonopsis, 5-10 parts of bighead atractylodes rhizome, 5-10 parts of angelica sinensis, 1-5 parts of red sage root, 1-5 parts of astragalus membranaceus, 1-5 parts of eclipta, 1-5 parts of radix bupleuri, 1-5 parts of poria cocos, 1-5 parts of dried orange peel, 1-5 parts of fried hawthorn and 1-5 parts of organic yeast selenium.
In an alternative way, in the traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-30 parts of silybum marianum, 25-30 parts of polygonum cuspidatum, 20-30 parts of water chestnut, 10-15 parts of honeysuckle, 5-10 parts of white paeony root, 5-10 parts of gynostemma pentaphylla, 10-15 parts of liquorice, 3-5 parts of radix codonopsis, 5-8 parts of bighead atractylodes rhizome, 5-10 parts of angelica sinensis, 1-5 parts of red sage root, 2-5 parts of astragalus membranaceus, 2-5 parts of eclipta, 3-5 parts of radix bupleuri, 3-5 parts of poria cocos, 3-5 parts of dried orange peel, 3-5 parts of fried hawthorn and 2-5 parts of organic yeast selenium.
Preferably, in the above traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 30 parts of polygonum cuspidatum, 20 parts of water chestnut, 10 parts of honeysuckle stem, 10 parts of white paeony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of angelica sinensis, 1 part of red-rooted salvia root, 2 parts of astragalus membranaceus, 2 parts of eclipta alba, 5 parts of radix bupleuri, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn and 2 parts of organic yeast selenium.
In addition, preferably, in the above traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 parts of silybum marianum, 30 parts of polygonum cuspidatum, 30 parts of water chestnut, 15 parts of honeysuckle stem, 5 parts of white paeony root, 10 parts of gynostemma pentaphylla, 10 parts of liquorice, 5 parts of codonopsis pilosula, 8 parts of bighead atractylodes rhizome, 10 parts of angelica, 5 parts of red sage root, 5 parts of astragalus membranaceus, 5 parts of eclipta alba, 3 parts of radix bupleuri, 3 parts of poria cocos, 3 parts of dried orange peel, 5 parts of fried hawthorn and 5 parts of organic yeast selenium.
In a second aspect, the present invention provides a method for preparing the traditional Chinese medicine composition according to the first aspect, the method comprising the following steps:
(1) Weighing raw materials with the weight ratio, mixing the rest raw materials except the organic yeast, and pulverizing;
(2) Adding 8-10 times of water into the above raw material powder except organic yeast selenium, extracting at 50-60deg.C for 2-3 hr, and transferring into fermentation tank;
(3) Adding white sugar 0.5-1 times of the total weight of the above materials except organic yeast selenium, stirring, cooling to 35deg.C, fermenting for 5-7 days, and filtering to obtain fermentation broth;
(4) Drying the fermentation broth;
(5) And (3) adding organic yeast selenium into the dried material obtained in the step (4), and mixing for 20-30 minutes to obtain the selenium-enriched soybean milk.
Alternatively, in the preparation method, in the step (3), adding a fermentation strain accounting for 0.05% -0.1% of the total weight of the raw materials for fermentation, wherein the filtration is 200-mesh filter cloth filtration, and in the step (4), the drying method is vacuum freeze drying, spray drying or vacuum drying.
Alternatively, in the above preparation method, in step (3), the fermentation strain is selected from one or more of the following: yeast, lactic acid bacteria, bacillus or enzymes.
Preferably, the fermentation strain is a yeast.
In a third aspect, the invention provides a fermented traditional Chinese medicine preparation for improving sub-health of sows, which comprises the traditional Chinese medicine composition described in the first aspect or the traditional Chinese medicine composition prepared by the preparation method described in the second aspect.
In a fourth aspect, the invention provides the use of the traditional Chinese medicine composition described in the first aspect or the fermented traditional Chinese medicine preparation described in the second aspect in preparing a medicament for improving sub-health of a sow.
Alternatively, in the above-mentioned use, the use is to increase the breeding rate of a replacement sow, reduce the second-born syndrome of the sow, eliminate the lacrimal spot swelling of the multiparatus sow, restore the pale red skin, eliminate the sub-health state of the sow, restore the sow to normal in oestrus and breeding, and reduce the elimination rate of the sow.
In a fifth aspect, the invention provides the use of the traditional Chinese medicine composition described in the first aspect or the fermented traditional Chinese medicine preparation described in the second aspect in preparing feed for improving sub-health of sows.
Alternatively, in the above-mentioned use, the Chinese medicinal composition or the fermented Chinese medicinal preparation is added in the feed in an amount of 0.05% -0.5% by weight.
Compared with the prior art, the invention has the following beneficial effects:
(1) The traditional Chinese medicine composition and the fermented traditional Chinese medicine preparation can comprehensively improve the sub-health state of sows, improve the health degree of sows, improve the breeding rate of the replacement sows, obviously reduce the two-embryo syndrome of the sows, eliminate the tear spot swelling of the multiperiod sows, restore the skin to be light red, eliminate the sub-health state of the sows, restore the oestrus and the breeding of the sows to be normal, and reduce the elimination rate of the sows.
(2) The traditional Chinese medicine composition and the raw materials selected from the fermented traditional Chinese medicines are common raw materials in the field of traditional Chinese veterinary medicines, so that the safety of the traditional Chinese medicine composition can be fully ensured, and the invention provides a green pollution-free veterinary medicine capable of replacing antibiotics.
Detailed Description
The traditional Chinese medicine composition disclosed by the invention has the effects of clearing heat and detoxicating, protecting liver and promoting bile flow, soothing liver and regulating qi, dispelling wind and promoting diuresis, removing blood stasis and relieving pain, promoting urination and treating stranguria, relieving cough and reducing sputum, replenishing qi and invigorating spleen and the like.
The specific description of various raw materials used in the traditional Chinese medicine composition and the fermented traditional Chinese medicine preparation is as follows:
silybum marianum (L.) C.H. Chen: is one or two-year herbaceous plants belonging to Compositae. The clematis fruit is used as a medicine, has bitter and cool nature, and has the effects of clearing heat and promoting diuresis, soothing liver and promoting bile flow. Modern pharmacological researches have proved that silybum marianum has the effects of protecting liver, reducing blood fat and resisting atherosclerosis plaque formation, and has the effects of protecting cardiovascular system and cerebral ischemia, and also has the effect of resisting platelet aggregation.
Giant knotweed rhizome: is a perennial herb of Polygonum of Polygonaceae. The rhizome is used for medicine, and has slightly bitter and slightly cold taste. Polygonum cuspidatum has the effects of dispelling wind and promoting diuresis, removing blood stasis and relieving pain, and relieving cough and reducing sputum. Can be used for treating arthralgia, jaundice due to damp-heat, amenorrhea, abdominal mass, scald due to hot water and fire, traumatic injury, carbuncle, swelling, sore, and cough with excessive phlegm.
Water chestnut flavor: is a perennial upright herb of the genus Caltha of the family Aristolochiaceae. Sweet, slightly bitter and pungent in taste, fragrant in smell, flat in nature and nontoxic. Orally taken to dispel wind, dispel qi, relieve summer-heat, induce diuresis, treat stranguria and remove food retention. Enters the urinary bladder channel of the small intestine. It is indicated for carbuncle, furuncle, etc. Is mainly used for treating urolithiasis, dysuria, hematuria, rheumatic edema, common cold, headache, wind cough, stomach ache and long-term accumulated disease pain.
Honeysuckle stem: is a plant of the genus lonicera of the family loniceraceae, and also called honeysuckle stem is a medicinal material. The honeysuckle stem has the effects of clearing heat and detoxicating, and the stir-baked charcoal has the effects of cooling blood and stopping bleeding, and can be used for treating exogenous wind-heat, epidemic febrile disease and fever. Can be used for treating cardiovascular diseases, reducing diastole amplitude of heart, and reducing venous pressure. Enhancing capillary permeability, lowering blood cholesterol, relieving spasm, eliminating phlegm, and relieving inflammation.
Radix Paeoniae alba is a plant of genus Cynanchum of family Asclepiadaceae, and perennial grass vine. Bitter, sour and slightly cold. Enter liver and spleen meridians. Calm liver and relieve pain, nourish blood, astringe yin and stop sweating. Can be used for treating headache, vertigo, hypochondriac pain, abdominal pain, limb spasm and pain, blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, and night sweat.
Gynostemma pentaphylla: is a climbing plant of Cucurbitaceae and Gynostemma herb. Gynostemma pentaphylla has cold nature and bitter taste, has the effects of clearing heat and detoxicating, relieving cough and clearing lung and eliminating phlegm, nourishing heart and tranquillizing, tonifying qi and producing sperm, can be used for reducing blood pressure, reducing blood fat, protecting liver, promoting sleep, treating gastroenteritis, tracheitis and sphagitis, and is used for anticancer clinical treatment of various cancers.
Licorice root: is dry root and rhizome of Glycyrrhiza uralensis Fisch of Glycyrrhiza of Leguminosae or Glycyrrhiza glabra, comprises glycyrrhizic acid, glycyrrhetinic acid, isoglycyrrhizic acid, glycyrrhizin, mannitol, glucose, sucrose, organic acid, volatile oil, etc. Sweet in taste and neutral in nature; it enters heart, lung, spleen and stomach meridians. Has effects in invigorating qi, invigorating spleen, moistening lung, relieving cough, clearing away heat and toxic materials, relieving spasm, and alleviating pain. Is used for treating spleen deficiency, listlessness, palpitation, cough, asthma, carbuncle, pharyngitis, poisoning due to food and medicine, and spasm and pain of limbs. Modern pharmacological studies prove that licorice has the effects of detoxification, antidiuretic, antitussive, anti-inflammatory and antiallergic, etc.
Radix codonopsis pilosulae: is dry root of radix Codonopsis, or radix Codonopsis belonging to Campanulaceae, contains volatile oil, baicalein glucoside, trace alkaloid, amino acid, polysaccharide and saponin, and contains syringin, n-hexyl-beta-D-glucopyranoside, dandelion cyprohol, friedelane, etc.; sweet in nature and smell, and flat; spleen and lung meridian entered; has the effects of invigorating spleen and replenishing qi, and invigorating spleen and replenishing lung. Is mainly used for treating weakness of spleen and stomach, diarrhea caused by overeating, tiredness and weakness, cough and asthma caused by deficiency of lung, and the like. Modern pharmacological researches have proved that radix Codonopsis has effects of lowering blood pressure, exciting nervous system, increasing blood sugar and promoting blood coagulation.
White atractylodes rhizome: is dried rhizome of Atractylodes macrocephala Koidz of Atractylodes of Compositae, and contains atractylol, beta-eucalyptol, atractylol, atractylis ovata ether, atractylis ovata lactone, dehydrated atractylis ovata lactone, fructose, inulin, etc. as effective components; warm, sweet and bitter in nature and taste; spleen and stomach meridian; has the effects of invigorating spleen and replenishing qi, eliminating dampness and promoting diuresis, consolidating superficial resistance and arresting sweating, tonifying qi and preventing miscarriage. Is used for treating spleen deficiency diarrhea, edema, spontaneous perspiration, and fetal irritability. Modern pharmacology proves that the bighead atractylodes rhizome has the effects of improving gastrointestinal functions, enhancing immune system functions, resisting tumors, promoting urination, regulating nervous systems and the like.
Chinese angelica root: is root of Angelica sinensis (oliv.) Diels of Angelica of Umbelliferae, and contains effective components such as neutral oil, acidic oil, organic acid, saccharide, vitamins, amino acids, etc.; sweet and pungent taste and warm nature; enter liver, heart and spleen meridians; has effects of replenishing blood, regulating menstruation, promoting blood circulation, relieving pain, loosening bowel, and relieving constipation. Is used for treating sallow complexion due to blood deficiency, menoxenia, amenorrhea, dysmenorrhea, blood deficiency, blood stagnation, pain due to blood cold, traumatic injury, rheumatalgia, carbuncle, skin ulcer, constipation due to intestinal dryness, etc. Modern pharmacology proves that angelica has the effects of resisting anemia, enhancing immunity, inhibiting platelet aggregation, resisting thrombus, resisting myocardial ischemia and hypoxia, expanding peripheral blood vessels, reducing blood pressure, exciting or inhibiting uterine smooth muscle, relaxing bronchial smooth muscle, reducing blood fat, resisting inflammation, protecting liver and the like.
Root of red-rooted salvia: is dry root and rhizome of Salvia Miltiorrhiza bge of Labiatae. Has effects of promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing heart fire, relieving restlessness, cooling blood, and resolving carbuncle. Can be used for treating chest pain, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease.
Radix astragali: is dry root of Astragalus membranaceus (Fisch.) bge, astragalus mongholicus (Fisch.) bge, or other similar plants of Leguminosae, and contains polysaccharide and saponins as effective components; slightly warm and sweet in nature and taste; enter lung and spleen meridians; has the effects of invigorating qi, strengthening yang, consolidating superficial resistance, stopping sweating, promoting wound healing, promoting granulation, promoting diuresis and relieving swelling. Is mainly used for treating spleen and lung qi deficiency, qi deficiency sinking, exterior deficiency sweating, sore and carbuncle difficult to be ulcerated and qi deficiency edema. Modern pharmacology proves that astragalus has the functions of enhancing immunity, promoting hematopoiesis, improving gastrointestinal tract function, regulating heart, regulating blood pressure, resisting tumor, resisting radiation, resisting fatigue, resisting oxidative damage and protecting liver.
Ecliptae herba: is dry aerial part of eclipta prostrata of Compositae. Has effects of nourishing liver and kidney, cooling blood and stopping bleeding. It is often used for deficiency of liver-yin and kidney-yin, loosening of teeth, premature graying of hair, dizziness, tinnitus, soreness of waist and knees, yin deficiency, blood heat, hematemesis, epistaxis, hematuria, bloody dysentery, metrorrhagia, hemorrhage due to trauma, and hemorrhage.
Bupleurum root: is dry root of Bupleurum scorzonerifolium of Umbelliferae or Bupleurum scorzonerifolium. Bupleuri radix is a commonly used exterior-releasing herb. The herb with the name of fumigating, mountain vegetable, mushroom grass and firewood is bitter in taste and slightly cold in nature, and enters liver and gallbladder meridians. Has the effects of relieving exterior and interior syndrome, soothing liver and raising yang. Can be used for treating common cold, fever, cold and heat, malaria, liver depression, qi stagnation, chest pain, rectocele, uterine prolapse, and menoxenia.
Poria cocos: is dry sclerotium of Poria cocos (Polyporaceae) and contains effective components such as beta-pachyman, pachymic acid, acetylpachymic acid, melic acid, apopore acid, 3 beta-hydroxy wool-supported trienoic acid, histidine, choline, adenine, etc.; the taste is flat, sweet and light; return to heart, lung, spleen, stomach and kidney meridians; has effects of promoting diuresis, removing dampness, invigorating spleen, invigorating middle warmer, and tranquilizing mind. Is used for treating phlegm dampness edema, oliguria, spleen deficiency, anorexia, loose stool, diarrhea, and restlessness. Modern pharmacology proves that poria cocos has the effects of promoting diuresis, soothing nerves, resisting inflammation and bacteria, resisting tumors, improving immunity, protecting liver, resisting rejection reaction, promoting hematopoiesis and the like.
Dried orange peel: is the dried mature pericarp of Citrus reticulata of Citrus of Rutaceae and its cultivar, and contains nobiletin, hesperidin, neohesperidin, hesperetin, p-hydroxyefrin, flavone compounds, etc. Pungent and bitter in nature and warm in nature; enter spleen and lung meridians. Has effects of regulating qi-flowing, invigorating spleen, eliminating dampness and resolving phlegm. It is used for treating spleen and stomach qi stagnation syndrome, emesis, singultus, wet phlegm, cough due to cold phlegm, and thoracic obstruction. Modern pharmacological researches prove that the dried orange peel has the effects of scavenging oxygen free radicals, resisting lipid peroxidation, promoting bile flow, reducing serum cholesterol and the like.
Parching fructus crataegi: hawthorn is a Chinese medicinal raw material used as both medicine and food, and has the effects of promoting digestion, invigorating stomach, promoting qi circulation, relieving fatigue, eliminating turbid pathogen and reducing blood lipid. Can be used for treating food stagnation, gastric distention, diarrhea, abdominal pain, blood stasis, amenorrhea, puerperal fatigue, thoracalgia, chest pain, hernia pain, and hyperlipidemia.
Organic yeast selenium: organic yeast Selenium (SY), namely, a yeast strain which realizes the specific high sulfur requirement according to the chemical similarity of selenium and sulfur, absorbs selenium element from a culture medium extremely lacking sulfur element, selenium absorbed into cells is integrated into a protein structure of yeast cells, and finally, the yeast organic selenium is obtained by washing and removing extracellular inorganic selenium. The organic yeast selenium is added into the daily ration of pigs to promote the growth of pigs, enhance the immune function, improve the reproductive performance, improve the pork quality and other nutrition functions. Not only can improve the selenium content in the body, but also can produce selenium-enriched food and promote the health of human beings.
The invention will be further illustrated with reference to specific examples. It should be understood that the detailed description and specific examples are intended for purposes of illustration only and are not intended to limit the scope of the invention.
The specific techniques or conditions are not identified in the examples and are described in the literature in this field or are carried out in accordance with the product specifications. The reagents or equipment used were conventional products available for purchase through regular channels, with no manufacturer noted.
The experimental methods in the following examples are conventional methods unless otherwise specified. The test materials used in the examples described below, unless otherwise specified, are all commercially available products.
Preparation examples:
example 1:
a traditional Chinese medicine composition for improving sub-health of sows is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 30 parts of polygonum cuspidatum, 20 parts of water chestnut, 10 parts of honeysuckle stem, 10 parts of white paeony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of angelica sinensis, 1 part of red-rooted salvia root, 2 parts of astragalus membranaceus, 2 parts of eclipta alba, 5 parts of radix bupleuri, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn and 2 parts of organic yeast selenium.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) Weighing the raw materials according to the weight ratio, mixing the rest raw materials except the organic yeast, and pulverizing into coarse powder;
(2) Adding 8 times of water into the coarse powder, extracting at 50 ℃ for 3 hours, and transferring to a fermentation tank;
(3) Adding white sugar 0.5 times of the total weight of the raw materials except for organic yeast selenium, stirring uniformly, cooling to 35 ℃, adding saccharomycetes accounting for 0.07% of the total weight of the raw materials for fermentation, fermenting for 7 days, and filtering with 200-mesh filter cloth to obtain fermentation liquor;
(4) Vacuum freeze drying the fermentation broth to powder;
(5) And crushing the dried materials, adding organic yeast selenium, and mixing for 20 minutes to obtain the example 1.
Example 2:
a traditional Chinese medicine composition for improving sub-health of sows is prepared from the following raw materials in parts by weight: 25 parts of silybum marianum, 30 parts of polygonum cuspidatum, 30 parts of water chestnut, 15 parts of honeysuckle stem, 5 parts of white paeony root, 10 parts of gynostemma pentaphylla, 10 parts of liquorice, 5 parts of codonopsis pilosula, 8 parts of bighead atractylodes rhizome, 10 parts of angelica, 5 parts of red sage root, 5 parts of astragalus membranaceus, 5 parts of eclipta alba, 3 parts of radix bupleuri, 3 parts of poria cocos, 3 parts of dried orange peel, 5 parts of fried hawthorn and 5 parts of organic yeast selenium.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) Weighing the raw materials according to the weight ratio, mixing the rest raw materials except the organic yeast, and pulverizing into coarse powder;
(2) Adding 10 times of water into the coarse powder, extracting at 60 ℃ for 2 hours, and transferring to a fermentation tank;
(3) Adding white sugar 1 times of the total weight of the raw materials except for organic yeast selenium, stirring uniformly, cooling to 35 ℃, adding yeast accounting for 0.1% of the total weight of the raw materials for fermentation, fermenting for 7 days, and filtering with 200-mesh filter cloth to obtain fermentation liquor;
(4) Vacuum freeze drying the fermentation broth to powder;
(5) And crushing the dried materials, adding organic yeast selenium, and mixing for 20 minutes to obtain the example 2.
Comparative example 1:
a traditional Chinese medicine composition for improving sub-health of sows is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 50 parts of water chestnut aroma, 10 parts of honeysuckle, 10 parts of white peony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of angelica sinensis, 1 part of salvia miltiorrhiza, 2 parts of astragalus membranaceus, 2 parts of eclipta, 5 parts of radix bupleuri, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn and 2 parts of organic yeast selenium.
The preparation method of the traditional Chinese medicine composition is the same as that of the example 1.
Comparative example 2:
a traditional Chinese medicine composition for improving sub-health of sows is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 30 parts of lophatherum gracile, 20 parts of water chestnut aroma, 10 parts of honeysuckle stem, 10 parts of white paeony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of angelica, 1 part of red-rooted salvia root, 2 parts of astragalus membranaceus, 2 parts of eclipta alba, 5 parts of radix bupleuri, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn and 2 parts of organic yeast selenium.
The preparation method of the traditional Chinese medicine composition is the same as that of the example 1.
Comparative example 3:
a traditional Chinese medicine composition for improving sub-health of sows is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 30 parts of polygonum cuspidatum, 20 parts of water chestnut, 10 parts of honeysuckle stem, 10 parts of white paeony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of angelica sinensis, 1 part of red-rooted salvia root, 2 parts of astragalus membranaceus, 2 parts of eclipta alba, 5 parts of radix bupleuri, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn and 2 parts of organic yeast selenium.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) Weighing the raw materials according to the weight ratio, mixing the rest raw materials except the organic yeast, and pulverizing into coarse powder;
(2) Adding 8 times of water into the coarse powder, and extracting at 50 ℃ for 3 hours;
(3) Vacuum freeze-drying the extract obtained in the step (2) to be powder; and
(4) And crushing the dried materials, adding organic yeast selenium, and mixing for 20 minutes to obtain the comparative example 3.
Effect examples: the traditional Chinese medicine composition has the effect of improving sub-health of sows
1. Test materials
In a large-scale pig farm in Shenyang city of Liaoning, 500 large-white and long-white binary sows are selected, 56 sows with similar expected production period and in sub-health condition are divided into 7 groups, 8 sows in each group are grouped as follows:
(1) Blank control group: 5 multiperies sows, 3 backup sows;
(2) Example 1 group: 6 multiparous sows and 2 backup sows;
(3) Example 2 group: 6 multiparous sows and 2 backup sows;
(4) Comparative example 1 group: 5 multiperies sows, 3 backup sows;
(5) Comparative example 2 group: 6 multiparous sows and 2 backup sows;
(6) Comparative example 3 group: 5 multiperies sows, 3 backup sows;
(7) Positive control group: 6 multiperies sows and 2 backup sows.
2. Test method
The test time is 90 days from gestation to mating, namely, about 10 days from 2022 to 7 months to 28 days from 9 months, and the total time is 80 days, and each group of sows can finish production within 80 days.
(1) The sow in the blank control group is only fed with ordinary feed. (2) The- (7) group is directly mixed in common feed, and is fed with 1kg of mixed feed and 1000kg of mixed feed, and the positive control group is QIZHENZENGZENGZENGYI granule, and comprises radix astragali, herba Epimedii, fructus Ligustri Lucidi, radix Codonopsis, atractylodis rhizoma, radix Angelicae sinensis, cimicifugae rhizoma, bupleuri radix, pericarpium Citri Tangerinae, and Glycyrrhrizae radix as main ingredients. (1) The- (7) groups are continuously fed for 80 days, and the crude drug amount of the feed added in the (2) - (7) groups is the same.
During the test period, each group was fed under the same conditions, and the feed, feeding environment and immunization conditions were the same.
3. Test results
3.1 sow Condition before the test
The 56 sows included the test had severe overall sub-health, had messy fur, and had whitish or yellowish skin with tear spots and swelling.
3.2 average number of born sow in each group
The experimental results are shown in table 1. The experimental results show that the average farrowing number of the sows in each experimental group is not greatly different as a whole. However, some variation trends can be seen, and the average litter size of the sows in each administration group is slightly higher than that of the blank control group, so that the sub-health condition of the sows can be improved to different degrees after administration. Of these, the example 1 and example 2 groups had the highest litter size, slightly higher than the comparative examples 1-3 and positive control groups. Among the groups of comparative examples 1 to 3, the average litter size of the group 3 sows of which the fermentation treatment was not performed was the lowest, suggesting that the fermentation treatment may have a higher influence on the efficacy of the Chinese medicinal composition of the present invention, and the average litter size of the group 1 to 2 sows of the comparative examples was also lower than that of the group 1 to 2, suggesting that the formulation of the Chinese medicinal composition of the present invention may have an important influence on the efficacy thereof, and that the efficacy may be affected to a different extent after omitting a part of the medicinal flavor or replacing it with another medicinal flavor.
3.3 weaning weight of piglets of each group for 25 days
The weight of the piglets can reflect the health condition of the piglets and indirectly the overall health state of the sows. During the experiment, the weight of piglets of the same day of age in each administration group (especially in the examples 1-2) is different to a greater extent than that of the blank control group, and the piglets of the administration group are generally plump in appearance and moist in hair color, while the piglets of the blank control group are sunken in the rib parts, and the overall mental condition is poor.
The experimental results are shown in table 1. Experimental results show that the weaning weights of piglets in each experimental group are different from those in a blank control group in 25 days. Of these, the piglets of example 1 and example 2 had the highest weaning weight for 25 days, significantly higher than the comparison 1-3 and positive control. Of the groups of comparative examples 1 to 3, the group 3 in which the piglets were not subjected to the fermentation treatment had the lowest weaning weight for 25 days and were only slightly higher than the blank group, and the results suggested that the fermentation treatment may have a higher effect on the efficacy of the Chinese medicinal composition of the present invention, and that the group 1 to 2 in which the piglets were subjected to the fermentation treatment had a lower weaning weight for 25 days than the group 1 to 2 in which the formulation of the Chinese medicinal composition of the present invention had a significant effect on the efficacy, and that the efficacy could be affected to a different extent when a part of the taste was omitted or replaced with another taste.
3.4 oestrus rate in 7 days for sows of each group
The number of non-production days of the sow is closely related to the profitability of the pig farm, and the problem has greater influence on a large pig farm. Therefore, the oestrus condition of the sow within 7 days after weaning directly represents the health state of the sow and the profitability of the pig farm.
The experimental results are shown in table 1. The experimental results show that the oestrus rate of each experimental group of sows is higher than that of the blank control group in different degrees within 7 days after weaning. The highest oestrus rate within 7 days after weaning of the sows in the example 1 group and the example 2 group is 100%, which is obviously higher than that of the sows in the comparative examples 1-3 and the positive control group. Of the groups of comparative examples 1 to 3, the sow of comparative example 3, in which the fermentation treatment was not performed, had the lowest oestrus rate (62.5%) within 7 days after weaning, but was slightly higher than that of the positive control group (50%), which suggested that the fermentation treatment may have a higher effect on the efficacy of the Chinese medicinal composition of the present invention, and that the sow of comparative example 1 to 2 had a lower oestrus rate within 7 days after weaning than that of the sow of example 1 to 2, which suggested that the formulation of the Chinese medicinal composition of the present invention also had an important effect on the efficacy thereof, and that it may have a different degree of effect on the efficacy when omitting a part of the drug flavor or replacing it with another drug flavor.
3.4 feeding of the sows of each group
The feeding amount of the sow is directly related to the milk of the sow, the lactation fat condition of the sow, the postweaning oestrus and the like. The test is carried out in summer, and at this time, most pig farms have the problem of low feed intake of pig groups.
The experimental results are shown in table 1. Experimental results show that the feed intake of the sows in each experimental group is higher than that of the blank control group. Wherein, the feeding amount of the sow in the example 1 group and the sow in the example 2 group is highest, which is obviously higher than that of the sow in the comparative examples 1-3 group and the positive control group. Of the groups of comparative examples 1 to 3, the group of comparative example 3, in which the fermentation treatment was not performed, had the lowest intake of sow, and the result suggested that the fermentation treatment may have a higher influence on the efficacy of the Chinese medicinal composition of the present invention, and the intake of sow of the group of comparative examples 1 to 2 was also lower than that of the group of examples 1 to 2, suggesting that the formulation of the Chinese medicinal composition of the present invention may have an important influence on the efficacy thereof, and that it may have a different degree of influence on the efficacy when a part of the taste was omitted or replaced with another taste.
3.5 sub-health symptomatic improvement of sows in groups
The experimental results are shown in table 1. Experimental results show that the sub-health symptom improvement condition of each experimental group of sows is better than that of a blank control group to different degrees. Among them, the sub-health symptoms of the sows in the group of the example 1 and the group of the example 2 are improved by 100%, the skin of all sows is recovered to be light red, tear spots and swelling bags are eliminated, or the skin color is resolved, the tear spots and swelling bags are reduced, and the experimental results are obviously better than those of the groups of the comparative examples 1-3 and the positive control group. Among the groups of comparative examples 1 to 3, the improvement of sub-health conditions of the sows of the group 3, in which the fermentation treatment was not performed, was most undesirable, and the results suggest that the fermentation treatment may have a higher effect on the efficacy of the Chinese medicinal composition of the present invention, and that the improvement of sub-health conditions of the sows of the group 1 to 2 is also inferior to that of the group 1 to 2, suggesting that the formulation of the Chinese medicinal composition of the present invention may have an important effect on the efficacy thereof, and that the efficacy may be affected to a different extent after omitting a part of the medicinal taste or replacing it with another medicinal taste.
Table 1: the invention relates to an effect of a traditional Chinese medicine composition in improving sub-health of sows
Note that: sub-health symptom improvement includes total number of animals with significantly improved and improved sub-health symptoms, wherein "significantly improved" refers to recovery of the sow skin from redness, removal of tear stains and swelling. "improvement" refers to a reduction in the color of the sow's skin, tear spots and swelling. The sub-health state refers to the white or yellowish skin of the sow, with the spots and swelling of tears.
In conclusion, the traditional Chinese medicine composition and the fermented traditional Chinese medicine preparation can comprehensively improve the sub-health state of sows, and improve the health degree of sows, so that the breeding rate of the replacement sows is improved, the two-embryo syndrome of the sows is obviously reduced, the tear-spot swelling of the multiparous sows is eliminated, the skin is recovered to be light red, the sub-health state of the sows is eliminated, the oestrus and the breeding of the sows are recovered to be normal, and the elimination rate of the sows is reduced. Moreover, during the whole experiment period, no toxic or side effect of the traditional Chinese medicine composition and the fermented traditional Chinese medicine preparation is observed in experimental sows.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (7)
1. A traditional Chinese medicine composition for improving sub-health of sows is characterized in that: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 30 parts of polygonum cuspidatum, 20 parts of water chestnut, 10 parts of honeysuckle stem, 10 parts of white paeony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of angelica, 1 part of red-rooted salvia root, 2 parts of astragalus root, 2 parts of eclipta alba, 5 parts of bupleurum, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn fruit, 2 parts of organic yeast selenium,
the preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) Weighing the raw materials according to the weight ratio, mixing the rest raw materials except the organic yeast selenium, and crushing into coarse powder;
(2) Adding 8 times of water into the coarse powder, extracting at 50 ℃ for 3 hours, and transferring to a fermentation tank;
(3) Adding white sugar 0.5 times of the total weight of the above raw materials except organic yeast selenium, stirring, cooling to 35deg.C, adding yeast 0.07% of the total weight of the above raw materials, fermenting for 7 days, fermenting with 200 mesh filter cloth, and filtering to obtain fermentation broth;
(4) Vacuum freeze drying the fermentation broth to powder;
(5) And then crushing the dried materials, adding organic yeast selenium, and mixing for 20 minutes to obtain the traditional Chinese medicine composition.
2. A traditional Chinese medicine composition for improving sub-health of sows is characterized in that: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 parts of silybum marianum, 30 parts of polygonum cuspidatum, 30 parts of water chestnut, 15 parts of honeysuckle stem, 5 parts of white paeony root, 10 parts of gynostemma pentaphylla, 10 parts of liquorice, 5 parts of codonopsis pilosula, 8 parts of bighead atractylodes rhizome, 10 parts of angelica, 5 parts of red sage root, 5 parts of astragalus membranaceus, 5 parts of eclipta alba, 3 parts of radix bupleuri, 3 parts of poria cocos, 3 parts of dried orange peel, 5 parts of fried hawthorn and 5 parts of organic yeast selenium,
the preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) Weighing the raw materials according to the weight ratio, mixing the rest raw materials except the organic yeast selenium, and crushing into coarse powder;
(2) Adding 10 times of water into the coarse powder, extracting at 60 ℃ for 2 hours, and transferring to a fermentation tank;
(3) Adding white sugar 1 times of the total weight of the above raw materials except organic yeast selenium, stirring, cooling to 35deg.C, adding yeast 0.1% of the total weight of the above raw materials, fermenting for 7 days, fermenting with 200 mesh filter cloth, and filtering to obtain fermentation broth;
(4) Vacuum freeze drying the fermentation broth to powder;
(5) And then crushing the dried materials, adding organic yeast selenium, and mixing for 20 minutes to obtain the traditional Chinese medicine composition.
3. A fermented traditional Chinese medicine preparation for improving sub-health of sows is characterized in that: the fermented traditional Chinese medicine preparation comprises the traditional Chinese medicine composition of claim 1 or claim 2.
4. Use of the traditional Chinese medicine composition according to claim 1 or claim 2 or the fermented traditional Chinese medicine preparation according to claim 3 for preparing a medicament for improving sub-health of sows.
5. Use according to claim 4, characterized in that: the application is to improve the breeding rate of the replacement gilts, reduce the two-embryo syndrome of the gilts, eliminate the lacrimal spot swelling of the multiparous gilts, restore the skin to be light red, eliminate the sub-health state of the gilts, restore the oestrus and the mating of the gilts to be normal, and reduce the elimination rate of the gilts.
6. Use of the traditional Chinese medicine composition according to claim 1 or claim 2 or the fermented traditional Chinese medicine preparation according to claim 3 for preparing feed for improving sub-health of sows.
7. Use according to claim 6, characterized in that: the traditional Chinese medicine composition or the fermented traditional Chinese medicine preparation is added into the feed in a weight percentage of 0.05% -0.5%.
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