CN115969909B - Traditional Chinese medicine composition and fermented traditional Chinese medicine preparation for improving sub-health of sow as well as preparation method and application of traditional Chinese medicine composition and fermented traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine composition and fermented traditional Chinese medicine preparation for improving sub-health of sow as well as preparation method and application of traditional Chinese medicine composition and fermented traditional Chinese medicine preparation Download PDFInfo
- Publication number
- CN115969909B CN115969909B CN202211423676.2A CN202211423676A CN115969909B CN 115969909 B CN115969909 B CN 115969909B CN 202211423676 A CN202211423676 A CN 202211423676A CN 115969909 B CN115969909 B CN 115969909B
- Authority
- CN
- China
- Prior art keywords
- parts
- traditional chinese
- chinese medicine
- sows
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 99
- 239000000203 mixture Substances 0.000 title claims abstract description 69
- 238000002360 preparation method Methods 0.000 title claims abstract description 41
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 40
- 239000002994 raw material Substances 0.000 claims abstract description 38
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims abstract description 37
- 229910052711 selenium Inorganic materials 0.000 claims abstract description 37
- 239000011669 selenium Substances 0.000 claims abstract description 37
- 241000132012 Atractylodes Species 0.000 claims abstract description 15
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 15
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 15
- 235000002956 Gynostemma pentaphyllum Nutrition 0.000 claims abstract description 15
- 244000197580 Poria cocos Species 0.000 claims abstract description 15
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 15
- 235000010841 Silybum marianum Nutrition 0.000 claims abstract description 14
- 244000272459 Silybum marianum Species 0.000 claims abstract description 14
- 235000006533 astragalus Nutrition 0.000 claims abstract description 14
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 14
- 230000008961 swelling Effects 0.000 claims abstract description 14
- 241000045403 Astragalus propinquus Species 0.000 claims abstract description 13
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 13
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 13
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 13
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 13
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 13
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 13
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 13
- 240000000171 Crataegus monogyna Species 0.000 claims abstract description 13
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 13
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 13
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 13
- 244000286838 Eclipta prostrata Species 0.000 claims abstract description 13
- 235000003283 Pachira macrocarpa Nutrition 0.000 claims abstract description 13
- 235000014364 Trapa natans Nutrition 0.000 claims abstract description 13
- 230000012173 estrus Effects 0.000 claims abstract description 13
- 235000009165 saligot Nutrition 0.000 claims abstract description 13
- 240000006509 Gynostemma pentaphyllum Species 0.000 claims abstract description 12
- 240000007164 Salvia officinalis Species 0.000 claims abstract description 12
- 235000011477 liquorice Nutrition 0.000 claims abstract description 12
- 235000006484 Paeonia officinalis Nutrition 0.000 claims abstract description 11
- 240000001341 Reynoutria japonica Species 0.000 claims abstract description 11
- 235000018167 Reynoutria japonica Nutrition 0.000 claims abstract description 11
- 238000009395 breeding Methods 0.000 claims abstract description 10
- 230000001488 breeding effect Effects 0.000 claims abstract description 10
- 208000011580 syndromic disease Diseases 0.000 claims abstract description 7
- 235000005412 red sage Nutrition 0.000 claims abstract description 6
- 230000008030 elimination Effects 0.000 claims abstract description 5
- 238000003379 elimination reaction Methods 0.000 claims abstract description 5
- 240000001085 Trapa natans Species 0.000 claims abstract description 4
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract 3
- 244000170916 Paeonia officinalis Species 0.000 claims abstract 3
- 238000000855 fermentation Methods 0.000 claims description 38
- 230000004151 fermentation Effects 0.000 claims description 38
- 239000000843 powder Substances 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 11
- 241000007126 Codonopsis pilosula Species 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 8
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 235000017276 Salvia Nutrition 0.000 claims description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 6
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 239000004744 fabric Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 240000002045 Guettarda speciosa Species 0.000 claims description 3
- 241000202726 Bupleurum Species 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 230000013011 mating Effects 0.000 claims description 2
- 229940107666 astragalus root Drugs 0.000 claims 1
- 230000036541 health Effects 0.000 abstract description 11
- 241000382455 Angelica sinensis Species 0.000 abstract description 9
- 241000756943 Codonopsis Species 0.000 abstract description 8
- 241001465754 Metazoa Species 0.000 abstract description 7
- 230000000694 effects Effects 0.000 description 41
- 230000001737 promoting effect Effects 0.000 description 22
- 210000004369 blood Anatomy 0.000 description 21
- 239000008280 blood Substances 0.000 description 21
- 230000000052 comparative effect Effects 0.000 description 21
- 210000000952 spleen Anatomy 0.000 description 21
- 210000004185 liver Anatomy 0.000 description 15
- 208000002193 Pain Diseases 0.000 description 14
- 235000019640 taste Nutrition 0.000 description 13
- 241001570521 Lonicera periclymenum Species 0.000 description 12
- 230000007812 deficiency Effects 0.000 description 12
- 210000004072 lung Anatomy 0.000 description 10
- 206010011224 Cough Diseases 0.000 description 9
- 241001083492 Trapa Species 0.000 description 9
- 241001106477 Paeoniaceae Species 0.000 description 8
- 208000004880 Polyuria Diseases 0.000 description 8
- 230000035619 diuresis Effects 0.000 description 8
- 210000002216 heart Anatomy 0.000 description 8
- 239000013641 positive control Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 206010062717 Increased upper airway secretion Diseases 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 208000026435 phlegm Diseases 0.000 description 7
- 230000001105 regulatory effect Effects 0.000 description 7
- 206010007247 Carbuncle Diseases 0.000 description 6
- 235000009508 confectionery Nutrition 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 230000006872 improvement Effects 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 201000000736 Amenorrhea Diseases 0.000 description 4
- 206010001928 Amenorrhoea Diseases 0.000 description 4
- 244000061520 Angelica archangelica Species 0.000 description 4
- 206010008479 Chest Pain Diseases 0.000 description 4
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 208000019255 Menstrual disease Diseases 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 4
- 208000005392 Spasm Diseases 0.000 description 4
- 231100000540 amenorrhea Toxicity 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000002708 enhancing effect Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000036039 immunity Effects 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- 238000010298 pulverizing process Methods 0.000 description 4
- 230000035900 sweating Effects 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 208000004998 Abdominal Pain Diseases 0.000 description 3
- 241000208838 Asteraceae Species 0.000 description 3
- 241000132011 Atractylodes lancea Species 0.000 description 3
- 241001065361 Gynostemma Species 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- -1 baicalein glucoside Chemical class 0.000 description 3
- 210000000941 bile Anatomy 0.000 description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 230000006806 disease prevention Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 206010016256 fatigue Diseases 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 239000011593 sulfur Substances 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 239000000273 veterinary drug Substances 0.000 description 3
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 2
- 241000208173 Apiaceae Species 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 2
- TYPSVDGIQAOBAD-DZGCQCFKSA-N Atractylone Chemical compound C([C@]1(C)C2)CCC(=C)[C@@H]1CC1=C2OC=C1C TYPSVDGIQAOBAD-DZGCQCFKSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000213015 Bupleurum scorzonerifolium Species 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 208000005171 Dysmenorrhea Diseases 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- 241000220485 Fabaceae Species 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 239000009636 Huang Qi Substances 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 235000021050 feed intake Nutrition 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 2
- 229960004949 glycyrrhizic acid Drugs 0.000 description 2
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 2
- 235000019410 glycyrrhizin Nutrition 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 208000006750 hematuria Diseases 0.000 description 2
- 230000011132 hemopoiesis Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 150000002596 lactones Chemical class 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 201000009240 nasopharyngitis Diseases 0.000 description 2
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 244000132619 red sage Species 0.000 description 2
- 230000001850 reproductive effect Effects 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- 235000017709 saponins Nutrition 0.000 description 2
- 210000002460 smooth muscle Anatomy 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- JVAZJLFFSJARQM-RMPHRYRLSA-N (2r,3r,4s,5s,6r)-2-hexoxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound CCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JVAZJLFFSJARQM-RMPHRYRLSA-N 0.000 description 1
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 1
- HOMSOWZTBJWNHP-UHFFFAOYSA-N 5-chlorothiadiazole Chemical compound ClC1=CN=NS1 HOMSOWZTBJWNHP-UHFFFAOYSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241000208327 Apocynaceae Species 0.000 description 1
- 241000758795 Aristolochiaceae Species 0.000 description 1
- 241001061264 Astragalus Species 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 241000092665 Atractylodes macrocephala Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- FXNFHKRTJBSTCS-UHFFFAOYSA-N Baicalein Natural products C=1C(=O)C=2C(O)=C(O)C(O)=CC=2OC=1C1=CC=CC=C1 FXNFHKRTJBSTCS-UHFFFAOYSA-N 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010007027 Calculus urinary Diseases 0.000 description 1
- 241000218208 Caltha Species 0.000 description 1
- 241000208671 Campanulaceae Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 241001672694 Citrus reticulata Species 0.000 description 1
- 241000218158 Clematis Species 0.000 description 1
- 241000219104 Cucurbitaceae Species 0.000 description 1
- 241000587240 Cynanchum Species 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- KVSNMTUIMXZPLU-UHFFFAOYSA-N D:A-friedo-oleanane Natural products CC12CCC3(C)C4CC(C)(C)CCC4(C)CCC3(C)C2CCC2(C)C1CCCC2C KVSNMTUIMXZPLU-UHFFFAOYSA-N 0.000 description 1
- 208000035240 Disease Resistance Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- 241000380130 Ehrharta erecta Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 241000202807 Glycyrrhiza Species 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- 235000000554 Glycyrrhiza uralensis Nutrition 0.000 description 1
- 240000008917 Glycyrrhiza uralensis Species 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 235000017443 Hedysarum boreale Nutrition 0.000 description 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 1
- 206010049077 Hernia pain Diseases 0.000 description 1
- QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 description 1
- 208000031361 Hiccup Diseases 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020710 Hyperphagia Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 235000010671 Lathyrus sativus Nutrition 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- 206010024642 Listless Diseases 0.000 description 1
- 241000245240 Lonicera Species 0.000 description 1
- 240000003915 Lophatherum gracile Species 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- OBIOZWXPDBWYHB-UHFFFAOYSA-N Nobiletin Natural products C1=CC(OC)=CC=C1C1=C(OC)C(=O)C2=C(OC)C(OC)=C(OC)C(OC)=C2O1 OBIOZWXPDBWYHB-UHFFFAOYSA-N 0.000 description 1
- JVAZJLFFSJARQM-UHFFFAOYSA-N O-n-hexyl beta-D-glucopyranoside Natural products CCCCCCOC1OC(CO)C(O)C(O)C1O JVAZJLFFSJARQM-UHFFFAOYSA-N 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 1
- 244000236658 Paeonia lactiflora Species 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 241000255969 Pieris brassicae Species 0.000 description 1
- 208000005374 Poisoning Diseases 0.000 description 1
- 241000219050 Polygonaceae Species 0.000 description 1
- 241000205407 Polygonum Species 0.000 description 1
- 241000222341 Polyporaceae Species 0.000 description 1
- 206010038084 Rectocele Diseases 0.000 description 1
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 description 1
- 244000153955 Reynoutria sachalinensis Species 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 241000235342 Saccharomycetes Species 0.000 description 1
- 241001558929 Sclerotium <basidiomycota> Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 240000001949 Taraxacum officinale Species 0.000 description 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 206010044302 Tracheitis Diseases 0.000 description 1
- 206010046814 Uterine prolapse Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 235000007244 Zea mays Nutrition 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000002686 anti-diuretic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002180 anti-stress Effects 0.000 description 1
- 229940124538 antidiuretic agent Drugs 0.000 description 1
- 239000003160 antidiuretic agent Substances 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- QUQPHWDTPGMPEX-UTWYECKDSA-N aurantiamarin Natural products COc1ccc(cc1O)[C@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2O1 QUQPHWDTPGMPEX-UTWYECKDSA-N 0.000 description 1
- 229940015301 baicalein Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 229940104299 cimicifugae rhizoma Drugs 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- APSNPMVGBGZYAJ-GLOOOPAXSA-N clematine Natural products COc1cc(ccc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2 APSNPMVGBGZYAJ-GLOOOPAXSA-N 0.000 description 1
- 230000009194 climbing Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 235000014106 fortified food Nutrition 0.000 description 1
- KVSNMTUIMXZPLU-XOZXFAFYSA-N friedelane Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3CCC[C@@H]1C KVSNMTUIMXZPLU-XOZXFAFYSA-N 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000037308 hair color Effects 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- AIONOLUJZLIMTK-AWEZNQCLSA-N hesperetin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O)=CC(O)=C2C(=O)C1 AIONOLUJZLIMTK-AWEZNQCLSA-N 0.000 description 1
- 229960001587 hesperetin Drugs 0.000 description 1
- AIONOLUJZLIMTK-UHFFFAOYSA-N hesperetin Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(O)=CC(O)=C2C(=O)C1 AIONOLUJZLIMTK-UHFFFAOYSA-N 0.000 description 1
- 235000010209 hesperetin Nutrition 0.000 description 1
- 229940025878 hesperidin Drugs 0.000 description 1
- VUYDGVRIQRPHFX-UHFFFAOYSA-N hesperidin Natural products COc1cc(ccc1O)C2CC(=O)c3c(O)cc(OC4OC(COC5OC(O)C(O)C(O)C5O)C(O)C(O)C4O)cc3O2 VUYDGVRIQRPHFX-UHFFFAOYSA-N 0.000 description 1
- QUQPHWDTPGMPEX-QJBIFVCTSA-N hesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-QJBIFVCTSA-N 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 229960002885 histidine Drugs 0.000 description 1
- FTODBIPDTXRIGS-UHFFFAOYSA-N homoeriodictyol Natural products C1=C(O)C(OC)=CC(C2OC3=CC(O)=CC(O)=C3C(=O)C2)=C1 FTODBIPDTXRIGS-UHFFFAOYSA-N 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 208000017971 listlessness Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- JVAZJLFFSJARQM-YBXAARCKSA-N n-Hexyl-beta-D-glucopyranoside Natural products CCCCCCO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O JVAZJLFFSJARQM-YBXAARCKSA-N 0.000 description 1
- ARGKVCXINMKCAZ-UZRWAPQLSA-N neohesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@H]3[C@@H]([C@H](O)[C@@H](O)[C@H](C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UZRWAPQLSA-N 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- MRIAQLRQZPPODS-UHFFFAOYSA-N nobiletin Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC(=O)C2=C(OC)C(OC)=C(OC)C(OC)=C2O1 MRIAQLRQZPPODS-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000020830 overeating Nutrition 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- VDYCLYGKCGVBHN-UHFFFAOYSA-N pachymaic acid Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC(=C)C(C)C)C(O)=O)C(O)CC21C VDYCLYGKCGVBHN-UHFFFAOYSA-N 0.000 description 1
- SRDNLMOBFKJOSD-UHFFFAOYSA-N pachymic acid Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C(O)=O)C(O)CC21C SRDNLMOBFKJOSD-UHFFFAOYSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000007505 plaque formation Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- QJVXKWHHAMZTBY-GCPOEHJPSA-N syringin Chemical compound COC1=CC(\C=C\CO)=CC(OC)=C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 QJVXKWHHAMZTBY-GCPOEHJPSA-N 0.000 description 1
- QJVXKWHHAMZTBY-KSXIZUIISA-N syringin Natural products COc1cc(C=CCO)cc(OC)c1O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O QJVXKWHHAMZTBY-KSXIZUIISA-N 0.000 description 1
- 210000004233 talus Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 230000003867 tiredness Effects 0.000 description 1
- 208000016255 tiredness Diseases 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 208000008281 urolithiasis Diseases 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of fermented traditional Chinese medicine preparations for animals, and particularly relates to a traditional Chinese medicine composition for improving sub-health of sows, a fermented traditional Chinese medicine preparation, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-30 parts of silybum marianum, 20-30 parts of polygonum cuspidatum, 20-30 parts of water chestnut, 10-15 parts of honeysuckle, 5-10 parts of white paeony root, 5-10 parts of gynostemma pentaphylla, 10-15 parts of liquorice, 1-5 parts of radix codonopsis, 5-10 parts of bighead atractylodes rhizome, 5-10 parts of angelica sinensis, 1-5 parts of red sage root, 1-5 parts of astragalus membranaceus, 1-5 parts of eclipta, 1-5 parts of radix bupleuri, 1-5 parts of poria cocos, 1-5 parts of dried orange peel, 1-5 parts of fried hawthorn and 1-5 parts of organic yeast selenium. The traditional Chinese medicine composition and the fermented traditional Chinese medicine preparation can comprehensively improve the sub-health state of sows, improve the health degree of sows, improve the breeding rate of the replacement sows, obviously reduce the two-embryo syndrome of the sows, eliminate the tear spot swelling of the multiperiod sows, restore the skin to be light red, eliminate the sub-health state of the sows, restore the oestrus and the breeding of the sows to be normal, and reduce the elimination rate of the sows.
Description
Technical Field
The invention belongs to the technical field of fermented traditional Chinese medicine preparations for animals, and particularly relates to a traditional Chinese medicine composition for improving sub-health of sows, a fermented traditional Chinese medicine preparation, a preparation method and application thereof.
Background
The sow is the core of pig farm cultivation, the disease resistance and the stress resistance of piglets are closely related to the sow, the health state of the sow is directly related to the exertion of the production performance and influences the production benefit of the pig farm, and particularly, the large-scale and intensive cultivation mode in modern animal husbandry cultivation brings higher requirements to the health level of the sow at a high-strength production rhythm. However, sows may be disturbed by the internal and external environments during growth, and once these toxins cannot be cleared in the pig body in time, the pig herd will release "sub-health signals", i.e. tear spots, old skin, swelling of the vulva, oestrus, dysplasia of the mammary glands, reduced levels of vaccine antibodies, etc. occur. Health care for sub-health state of sows has become the core of each big pig farm, but the side effects that traditional antibiotic health care causes the decrease of the physique of sows, the decrease of reproductive production performance and the like have been increasingly questioned by industry people. Therefore, a green pollution-free drug capable of replacing antibiotics is needed to improve the sub-health condition of sows and improve the productivity of the sows.
In recent years, the anti-aging and anti-subtracting call for the raising industry is higher and higher, and the veterinary drug has the advantages of remarkable control effect, relatively small toxic and side effects on livestock and poultry, no harmful residues in animal foods and difficult drug resistance generation, and the development of veterinary drug products and feed additives is attracting attention increasingly at present, which is sensitive to food safety problems. The application of the traditional Chinese veterinary medicine is used for satisfying the objective requirement of livestock breeding, reflecting the viewpoint of' no disease prevention in the traditional Chinese medicine control system, leading the traditional Chinese veterinary medicine to participate in animal epidemic disease prevention, anti-stress and antibacterial, fully regulating the nonspecific immunity of animal organisms, coordinating the physiological functions of the organisms and improving the disease prevention capability of the organisms.
The fermentation technology has thousands of years history in China, but the traditional Chinese medicine prepared by fermentation is not very much, the reasons for the traditional Chinese medicine are greatly related to the screening and culture of microorganism varieties and the traditional Chinese medicine variety suitable for fermentation, the traditional Chinese medicine fermentation technology has lower efficiency, and the requirement of industrial production is difficult to meet. In recent years, with the development of microecology, modern bioengineering technology is increasingly applied to the field of traditional Chinese medicines, especially fermentation technology. The traditional Chinese medicine can improve the performance of the medicine after fermentation, generate new medicine effect and provide basis for the development of new medicine sources.
In view of this, the present inventors have developed a traditional Chinese medicine composition and a fermented traditional Chinese medicine preparation capable of improving sub-health status of sow in combination with the technical field of veterinary drug preparation.
Disclosure of Invention
In order to solve the technical problems, the invention provides a traditional Chinese medicine composition and a fermented traditional Chinese medicine preparation for improving sub-health of sows, and a preparation method and application thereof.
Specifically, the invention is realized through the following technical schemes:
in a first aspect, the invention provides a traditional Chinese medicine composition for improving sub-health of a sow, which is prepared from the following raw materials in parts by weight: 20-30 parts of silybum marianum, 20-30 parts of polygonum cuspidatum, 20-30 parts of water chestnut, 10-15 parts of honeysuckle, 5-10 parts of white paeony root, 5-10 parts of gynostemma pentaphylla, 10-15 parts of liquorice, 1-5 parts of radix codonopsis, 5-10 parts of bighead atractylodes rhizome, 5-10 parts of angelica sinensis, 1-5 parts of red sage root, 1-5 parts of astragalus membranaceus, 1-5 parts of eclipta, 1-5 parts of radix bupleuri, 1-5 parts of poria cocos, 1-5 parts of dried orange peel, 1-5 parts of fried hawthorn and 1-5 parts of organic yeast selenium.
In an alternative way, in the traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-30 parts of silybum marianum, 25-30 parts of polygonum cuspidatum, 20-30 parts of water chestnut, 10-15 parts of honeysuckle, 5-10 parts of white paeony root, 5-10 parts of gynostemma pentaphylla, 10-15 parts of liquorice, 3-5 parts of radix codonopsis, 5-8 parts of bighead atractylodes rhizome, 5-10 parts of angelica sinensis, 1-5 parts of red sage root, 2-5 parts of astragalus membranaceus, 2-5 parts of eclipta, 3-5 parts of radix bupleuri, 3-5 parts of poria cocos, 3-5 parts of dried orange peel, 3-5 parts of fried hawthorn and 2-5 parts of organic yeast selenium.
Preferably, in the above traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 30 parts of polygonum cuspidatum, 20 parts of water chestnut, 10 parts of honeysuckle stem, 10 parts of white paeony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of angelica sinensis, 1 part of red-rooted salvia root, 2 parts of astragalus membranaceus, 2 parts of eclipta alba, 5 parts of radix bupleuri, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn and 2 parts of organic yeast selenium.
In addition, preferably, in the above traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 parts of silybum marianum, 30 parts of polygonum cuspidatum, 30 parts of water chestnut, 15 parts of honeysuckle stem, 5 parts of white paeony root, 10 parts of gynostemma pentaphylla, 10 parts of liquorice, 5 parts of codonopsis pilosula, 8 parts of bighead atractylodes rhizome, 10 parts of angelica, 5 parts of red sage root, 5 parts of astragalus membranaceus, 5 parts of eclipta alba, 3 parts of radix bupleuri, 3 parts of poria cocos, 3 parts of dried orange peel, 5 parts of fried hawthorn and 5 parts of organic yeast selenium.
In a second aspect, the present invention provides a method for preparing the traditional Chinese medicine composition according to the first aspect, the method comprising the following steps:
(1) Weighing raw materials with the weight ratio, mixing the rest raw materials except the organic yeast, and pulverizing;
(2) Adding 8-10 times of water into the above raw material powder except organic yeast selenium, extracting at 50-60deg.C for 2-3 hr, and transferring into fermentation tank;
(3) Adding white sugar 0.5-1 times of the total weight of the above materials except organic yeast selenium, stirring, cooling to 35deg.C, fermenting for 5-7 days, and filtering to obtain fermentation broth;
(4) Drying the fermentation broth;
(5) And (3) adding organic yeast selenium into the dried material obtained in the step (4), and mixing for 20-30 minutes to obtain the selenium-enriched soybean milk.
Alternatively, in the preparation method, in the step (3), adding a fermentation strain accounting for 0.05% -0.1% of the total weight of the raw materials for fermentation, wherein the filtration is 200-mesh filter cloth filtration, and in the step (4), the drying method is vacuum freeze drying, spray drying or vacuum drying.
Alternatively, in the above preparation method, in step (3), the fermentation strain is selected from one or more of the following: yeast, lactic acid bacteria, bacillus or enzymes.
Preferably, the fermentation strain is a yeast.
In a third aspect, the invention provides a fermented traditional Chinese medicine preparation for improving sub-health of sows, which comprises the traditional Chinese medicine composition described in the first aspect or the traditional Chinese medicine composition prepared by the preparation method described in the second aspect.
In a fourth aspect, the invention provides the use of the traditional Chinese medicine composition described in the first aspect or the fermented traditional Chinese medicine preparation described in the second aspect in preparing a medicament for improving sub-health of a sow.
Alternatively, in the above-mentioned use, the use is to increase the breeding rate of a replacement sow, reduce the second-born syndrome of the sow, eliminate the lacrimal spot swelling of the multiparatus sow, restore the pale red skin, eliminate the sub-health state of the sow, restore the sow to normal in oestrus and breeding, and reduce the elimination rate of the sow.
In a fifth aspect, the invention provides the use of the traditional Chinese medicine composition described in the first aspect or the fermented traditional Chinese medicine preparation described in the second aspect in preparing feed for improving sub-health of sows.
Alternatively, in the above-mentioned use, the Chinese medicinal composition or the fermented Chinese medicinal preparation is added in the feed in an amount of 0.05% -0.5% by weight.
Compared with the prior art, the invention has the following beneficial effects:
(1) The traditional Chinese medicine composition and the fermented traditional Chinese medicine preparation can comprehensively improve the sub-health state of sows, improve the health degree of sows, improve the breeding rate of the replacement sows, obviously reduce the two-embryo syndrome of the sows, eliminate the tear spot swelling of the multiperiod sows, restore the skin to be light red, eliminate the sub-health state of the sows, restore the oestrus and the breeding of the sows to be normal, and reduce the elimination rate of the sows.
(2) The traditional Chinese medicine composition and the raw materials selected from the fermented traditional Chinese medicines are common raw materials in the field of traditional Chinese veterinary medicines, so that the safety of the traditional Chinese medicine composition can be fully ensured, and the invention provides a green pollution-free veterinary medicine capable of replacing antibiotics.
Detailed Description
The traditional Chinese medicine composition disclosed by the invention has the effects of clearing heat and detoxicating, protecting liver and promoting bile flow, soothing liver and regulating qi, dispelling wind and promoting diuresis, removing blood stasis and relieving pain, promoting urination and treating stranguria, relieving cough and reducing sputum, replenishing qi and invigorating spleen and the like.
The specific description of various raw materials used in the traditional Chinese medicine composition and the fermented traditional Chinese medicine preparation is as follows:
silybum marianum (L.) C.H. Chen: is one or two-year herbaceous plants belonging to Compositae. The clematis fruit is used as a medicine, has bitter and cool nature, and has the effects of clearing heat and promoting diuresis, soothing liver and promoting bile flow. Modern pharmacological researches have proved that silybum marianum has the effects of protecting liver, reducing blood fat and resisting atherosclerosis plaque formation, and has the effects of protecting cardiovascular system and cerebral ischemia, and also has the effect of resisting platelet aggregation.
Giant knotweed rhizome: is a perennial herb of Polygonum of Polygonaceae. The rhizome is used for medicine, and has slightly bitter and slightly cold taste. Polygonum cuspidatum has the effects of dispelling wind and promoting diuresis, removing blood stasis and relieving pain, and relieving cough and reducing sputum. Can be used for treating arthralgia, jaundice due to damp-heat, amenorrhea, abdominal mass, scald due to hot water and fire, traumatic injury, carbuncle, swelling, sore, and cough with excessive phlegm.
Water chestnut flavor: is a perennial upright herb of the genus Caltha of the family Aristolochiaceae. Sweet, slightly bitter and pungent in taste, fragrant in smell, flat in nature and nontoxic. Orally taken to dispel wind, dispel qi, relieve summer-heat, induce diuresis, treat stranguria and remove food retention. Enters the urinary bladder channel of the small intestine. It is indicated for carbuncle, furuncle, etc. Is mainly used for treating urolithiasis, dysuria, hematuria, rheumatic edema, common cold, headache, wind cough, stomach ache and long-term accumulated disease pain.
Honeysuckle stem: is a plant of the genus lonicera of the family loniceraceae, and also called honeysuckle stem is a medicinal material. The honeysuckle stem has the effects of clearing heat and detoxicating, and the stir-baked charcoal has the effects of cooling blood and stopping bleeding, and can be used for treating exogenous wind-heat, epidemic febrile disease and fever. Can be used for treating cardiovascular diseases, reducing diastole amplitude of heart, and reducing venous pressure. Enhancing capillary permeability, lowering blood cholesterol, relieving spasm, eliminating phlegm, and relieving inflammation.
Radix Paeoniae alba is a plant of genus Cynanchum of family Asclepiadaceae, and perennial grass vine. Bitter, sour and slightly cold. Enter liver and spleen meridians. Calm liver and relieve pain, nourish blood, astringe yin and stop sweating. Can be used for treating headache, vertigo, hypochondriac pain, abdominal pain, limb spasm and pain, blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, and night sweat.
Gynostemma pentaphylla: is a climbing plant of Cucurbitaceae and Gynostemma herb. Gynostemma pentaphylla has cold nature and bitter taste, has the effects of clearing heat and detoxicating, relieving cough and clearing lung and eliminating phlegm, nourishing heart and tranquillizing, tonifying qi and producing sperm, can be used for reducing blood pressure, reducing blood fat, protecting liver, promoting sleep, treating gastroenteritis, tracheitis and sphagitis, and is used for anticancer clinical treatment of various cancers.
Licorice root: is dry root and rhizome of Glycyrrhiza uralensis Fisch of Glycyrrhiza of Leguminosae or Glycyrrhiza glabra, comprises glycyrrhizic acid, glycyrrhetinic acid, isoglycyrrhizic acid, glycyrrhizin, mannitol, glucose, sucrose, organic acid, volatile oil, etc. Sweet in taste and neutral in nature; it enters heart, lung, spleen and stomach meridians. Has effects in invigorating qi, invigorating spleen, moistening lung, relieving cough, clearing away heat and toxic materials, relieving spasm, and alleviating pain. Is used for treating spleen deficiency, listlessness, palpitation, cough, asthma, carbuncle, pharyngitis, poisoning due to food and medicine, and spasm and pain of limbs. Modern pharmacological studies prove that licorice has the effects of detoxification, antidiuretic, antitussive, anti-inflammatory and antiallergic, etc.
Radix codonopsis pilosulae: is dry root of radix Codonopsis, or radix Codonopsis belonging to Campanulaceae, contains volatile oil, baicalein glucoside, trace alkaloid, amino acid, polysaccharide and saponin, and contains syringin, n-hexyl-beta-D-glucopyranoside, dandelion cyprohol, friedelane, etc.; sweet in nature and smell, and flat; spleen and lung meridian entered; has the effects of invigorating spleen and replenishing qi, and invigorating spleen and replenishing lung. Is mainly used for treating weakness of spleen and stomach, diarrhea caused by overeating, tiredness and weakness, cough and asthma caused by deficiency of lung, and the like. Modern pharmacological researches have proved that radix Codonopsis has effects of lowering blood pressure, exciting nervous system, increasing blood sugar and promoting blood coagulation.
White atractylodes rhizome: is dried rhizome of Atractylodes macrocephala Koidz of Atractylodes of Compositae, and contains atractylol, beta-eucalyptol, atractylol, atractylis ovata ether, atractylis ovata lactone, dehydrated atractylis ovata lactone, fructose, inulin, etc. as effective components; warm, sweet and bitter in nature and taste; spleen and stomach meridian; has the effects of invigorating spleen and replenishing qi, eliminating dampness and promoting diuresis, consolidating superficial resistance and arresting sweating, tonifying qi and preventing miscarriage. Is used for treating spleen deficiency diarrhea, edema, spontaneous perspiration, and fetal irritability. Modern pharmacology proves that the bighead atractylodes rhizome has the effects of improving gastrointestinal functions, enhancing immune system functions, resisting tumors, promoting urination, regulating nervous systems and the like.
Chinese angelica root: is root of Angelica sinensis (oliv.) Diels of Angelica of Umbelliferae, and contains effective components such as neutral oil, acidic oil, organic acid, saccharide, vitamins, amino acids, etc.; sweet and pungent taste and warm nature; enter liver, heart and spleen meridians; has effects of replenishing blood, regulating menstruation, promoting blood circulation, relieving pain, loosening bowel, and relieving constipation. Is used for treating sallow complexion due to blood deficiency, menoxenia, amenorrhea, dysmenorrhea, blood deficiency, blood stagnation, pain due to blood cold, traumatic injury, rheumatalgia, carbuncle, skin ulcer, constipation due to intestinal dryness, etc. Modern pharmacology proves that angelica has the effects of resisting anemia, enhancing immunity, inhibiting platelet aggregation, resisting thrombus, resisting myocardial ischemia and hypoxia, expanding peripheral blood vessels, reducing blood pressure, exciting or inhibiting uterine smooth muscle, relaxing bronchial smooth muscle, reducing blood fat, resisting inflammation, protecting liver and the like.
Root of red-rooted salvia: is dry root and rhizome of Salvia Miltiorrhiza bge of Labiatae. Has effects of promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing heart fire, relieving restlessness, cooling blood, and resolving carbuncle. Can be used for treating chest pain, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease.
Radix astragali: is dry root of Astragalus membranaceus (Fisch.) bge, astragalus mongholicus (Fisch.) bge, or other similar plants of Leguminosae, and contains polysaccharide and saponins as effective components; slightly warm and sweet in nature and taste; enter lung and spleen meridians; has the effects of invigorating qi, strengthening yang, consolidating superficial resistance, stopping sweating, promoting wound healing, promoting granulation, promoting diuresis and relieving swelling. Is mainly used for treating spleen and lung qi deficiency, qi deficiency sinking, exterior deficiency sweating, sore and carbuncle difficult to be ulcerated and qi deficiency edema. Modern pharmacology proves that astragalus has the functions of enhancing immunity, promoting hematopoiesis, improving gastrointestinal tract function, regulating heart, regulating blood pressure, resisting tumor, resisting radiation, resisting fatigue, resisting oxidative damage and protecting liver.
Ecliptae herba: is dry aerial part of eclipta prostrata of Compositae. Has effects of nourishing liver and kidney, cooling blood and stopping bleeding. It is often used for deficiency of liver-yin and kidney-yin, loosening of teeth, premature graying of hair, dizziness, tinnitus, soreness of waist and knees, yin deficiency, blood heat, hematemesis, epistaxis, hematuria, bloody dysentery, metrorrhagia, hemorrhage due to trauma, and hemorrhage.
Bupleurum root: is dry root of Bupleurum scorzonerifolium of Umbelliferae or Bupleurum scorzonerifolium. Bupleuri radix is a commonly used exterior-releasing herb. The herb with the name of fumigating, mountain vegetable, mushroom grass and firewood is bitter in taste and slightly cold in nature, and enters liver and gallbladder meridians. Has the effects of relieving exterior and interior syndrome, soothing liver and raising yang. Can be used for treating common cold, fever, cold and heat, malaria, liver depression, qi stagnation, chest pain, rectocele, uterine prolapse, and menoxenia.
Poria cocos: is dry sclerotium of Poria cocos (Polyporaceae) and contains effective components such as beta-pachyman, pachymic acid, acetylpachymic acid, melic acid, apopore acid, 3 beta-hydroxy wool-supported trienoic acid, histidine, choline, adenine, etc.; the taste is flat, sweet and light; return to heart, lung, spleen, stomach and kidney meridians; has effects of promoting diuresis, removing dampness, invigorating spleen, invigorating middle warmer, and tranquilizing mind. Is used for treating phlegm dampness edema, oliguria, spleen deficiency, anorexia, loose stool, diarrhea, and restlessness. Modern pharmacology proves that poria cocos has the effects of promoting diuresis, soothing nerves, resisting inflammation and bacteria, resisting tumors, improving immunity, protecting liver, resisting rejection reaction, promoting hematopoiesis and the like.
Dried orange peel: is the dried mature pericarp of Citrus reticulata of Citrus of Rutaceae and its cultivar, and contains nobiletin, hesperidin, neohesperidin, hesperetin, p-hydroxyefrin, flavone compounds, etc. Pungent and bitter in nature and warm in nature; enter spleen and lung meridians. Has effects of regulating qi-flowing, invigorating spleen, eliminating dampness and resolving phlegm. It is used for treating spleen and stomach qi stagnation syndrome, emesis, singultus, wet phlegm, cough due to cold phlegm, and thoracic obstruction. Modern pharmacological researches prove that the dried orange peel has the effects of scavenging oxygen free radicals, resisting lipid peroxidation, promoting bile flow, reducing serum cholesterol and the like.
Parching fructus crataegi: hawthorn is a Chinese medicinal raw material used as both medicine and food, and has the effects of promoting digestion, invigorating stomach, promoting qi circulation, relieving fatigue, eliminating turbid pathogen and reducing blood lipid. Can be used for treating food stagnation, gastric distention, diarrhea, abdominal pain, blood stasis, amenorrhea, puerperal fatigue, thoracalgia, chest pain, hernia pain, and hyperlipidemia.
Organic yeast selenium: organic yeast Selenium (SY), namely, a yeast strain which realizes the specific high sulfur requirement according to the chemical similarity of selenium and sulfur, absorbs selenium element from a culture medium extremely lacking sulfur element, selenium absorbed into cells is integrated into a protein structure of yeast cells, and finally, the yeast organic selenium is obtained by washing and removing extracellular inorganic selenium. The organic yeast selenium is added into the daily ration of pigs to promote the growth of pigs, enhance the immune function, improve the reproductive performance, improve the pork quality and other nutrition functions. Not only can improve the selenium content in the body, but also can produce selenium-enriched food and promote the health of human beings.
The invention will be further illustrated with reference to specific examples. It should be understood that the detailed description and specific examples are intended for purposes of illustration only and are not intended to limit the scope of the invention.
The specific techniques or conditions are not identified in the examples and are described in the literature in this field or are carried out in accordance with the product specifications. The reagents or equipment used were conventional products available for purchase through regular channels, with no manufacturer noted.
The experimental methods in the following examples are conventional methods unless otherwise specified. The test materials used in the examples described below, unless otherwise specified, are all commercially available products.
Preparation examples:
example 1:
a traditional Chinese medicine composition for improving sub-health of sows is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 30 parts of polygonum cuspidatum, 20 parts of water chestnut, 10 parts of honeysuckle stem, 10 parts of white paeony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of angelica sinensis, 1 part of red-rooted salvia root, 2 parts of astragalus membranaceus, 2 parts of eclipta alba, 5 parts of radix bupleuri, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn and 2 parts of organic yeast selenium.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) Weighing the raw materials according to the weight ratio, mixing the rest raw materials except the organic yeast, and pulverizing into coarse powder;
(2) Adding 8 times of water into the coarse powder, extracting at 50 ℃ for 3 hours, and transferring to a fermentation tank;
(3) Adding white sugar 0.5 times of the total weight of the raw materials except for organic yeast selenium, stirring uniformly, cooling to 35 ℃, adding saccharomycetes accounting for 0.07% of the total weight of the raw materials for fermentation, fermenting for 7 days, and filtering with 200-mesh filter cloth to obtain fermentation liquor;
(4) Vacuum freeze drying the fermentation broth to powder;
(5) And crushing the dried materials, adding organic yeast selenium, and mixing for 20 minutes to obtain the example 1.
Example 2:
a traditional Chinese medicine composition for improving sub-health of sows is prepared from the following raw materials in parts by weight: 25 parts of silybum marianum, 30 parts of polygonum cuspidatum, 30 parts of water chestnut, 15 parts of honeysuckle stem, 5 parts of white paeony root, 10 parts of gynostemma pentaphylla, 10 parts of liquorice, 5 parts of codonopsis pilosula, 8 parts of bighead atractylodes rhizome, 10 parts of angelica, 5 parts of red sage root, 5 parts of astragalus membranaceus, 5 parts of eclipta alba, 3 parts of radix bupleuri, 3 parts of poria cocos, 3 parts of dried orange peel, 5 parts of fried hawthorn and 5 parts of organic yeast selenium.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) Weighing the raw materials according to the weight ratio, mixing the rest raw materials except the organic yeast, and pulverizing into coarse powder;
(2) Adding 10 times of water into the coarse powder, extracting at 60 ℃ for 2 hours, and transferring to a fermentation tank;
(3) Adding white sugar 1 times of the total weight of the raw materials except for organic yeast selenium, stirring uniformly, cooling to 35 ℃, adding yeast accounting for 0.1% of the total weight of the raw materials for fermentation, fermenting for 7 days, and filtering with 200-mesh filter cloth to obtain fermentation liquor;
(4) Vacuum freeze drying the fermentation broth to powder;
(5) And crushing the dried materials, adding organic yeast selenium, and mixing for 20 minutes to obtain the example 2.
Comparative example 1:
a traditional Chinese medicine composition for improving sub-health of sows is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 50 parts of water chestnut aroma, 10 parts of honeysuckle, 10 parts of white peony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of angelica sinensis, 1 part of salvia miltiorrhiza, 2 parts of astragalus membranaceus, 2 parts of eclipta, 5 parts of radix bupleuri, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn and 2 parts of organic yeast selenium.
The preparation method of the traditional Chinese medicine composition is the same as that of the example 1.
Comparative example 2:
a traditional Chinese medicine composition for improving sub-health of sows is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 30 parts of lophatherum gracile, 20 parts of water chestnut aroma, 10 parts of honeysuckle stem, 10 parts of white paeony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of angelica, 1 part of red-rooted salvia root, 2 parts of astragalus membranaceus, 2 parts of eclipta alba, 5 parts of radix bupleuri, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn and 2 parts of organic yeast selenium.
The preparation method of the traditional Chinese medicine composition is the same as that of the example 1.
Comparative example 3:
a traditional Chinese medicine composition for improving sub-health of sows is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 30 parts of polygonum cuspidatum, 20 parts of water chestnut, 10 parts of honeysuckle stem, 10 parts of white paeony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of angelica sinensis, 1 part of red-rooted salvia root, 2 parts of astragalus membranaceus, 2 parts of eclipta alba, 5 parts of radix bupleuri, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn and 2 parts of organic yeast selenium.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) Weighing the raw materials according to the weight ratio, mixing the rest raw materials except the organic yeast, and pulverizing into coarse powder;
(2) Adding 8 times of water into the coarse powder, and extracting at 50 ℃ for 3 hours;
(3) Vacuum freeze-drying the extract obtained in the step (2) to be powder; and
(4) And crushing the dried materials, adding organic yeast selenium, and mixing for 20 minutes to obtain the comparative example 3.
Effect examples: the traditional Chinese medicine composition has the effect of improving sub-health of sows
1. Test materials
In a large-scale pig farm in Shenyang city of Liaoning, 500 large-white and long-white binary sows are selected, 56 sows with similar expected production period and in sub-health condition are divided into 7 groups, 8 sows in each group are grouped as follows:
(1) Blank control group: 5 multiperies sows, 3 backup sows;
(2) Example 1 group: 6 multiparous sows and 2 backup sows;
(3) Example 2 group: 6 multiparous sows and 2 backup sows;
(4) Comparative example 1 group: 5 multiperies sows, 3 backup sows;
(5) Comparative example 2 group: 6 multiparous sows and 2 backup sows;
(6) Comparative example 3 group: 5 multiperies sows, 3 backup sows;
(7) Positive control group: 6 multiperies sows and 2 backup sows.
2. Test method
The test time is 90 days from gestation to mating, namely, about 10 days from 2022 to 7 months to 28 days from 9 months, and the total time is 80 days, and each group of sows can finish production within 80 days.
(1) The sow in the blank control group is only fed with ordinary feed. (2) The- (7) group is directly mixed in common feed, and is fed with 1kg of mixed feed and 1000kg of mixed feed, and the positive control group is QIZHENZENGZENGZENGYI granule, and comprises radix astragali, herba Epimedii, fructus Ligustri Lucidi, radix Codonopsis, atractylodis rhizoma, radix Angelicae sinensis, cimicifugae rhizoma, bupleuri radix, pericarpium Citri Tangerinae, and Glycyrrhrizae radix as main ingredients. (1) The- (7) groups are continuously fed for 80 days, and the crude drug amount of the feed added in the (2) - (7) groups is the same.
During the test period, each group was fed under the same conditions, and the feed, feeding environment and immunization conditions were the same.
3. Test results
3.1 sow Condition before the test
The 56 sows included the test had severe overall sub-health, had messy fur, and had whitish or yellowish skin with tear spots and swelling.
3.2 average number of born sow in each group
The experimental results are shown in table 1. The experimental results show that the average farrowing number of the sows in each experimental group is not greatly different as a whole. However, some variation trends can be seen, and the average litter size of the sows in each administration group is slightly higher than that of the blank control group, so that the sub-health condition of the sows can be improved to different degrees after administration. Of these, the example 1 and example 2 groups had the highest litter size, slightly higher than the comparative examples 1-3 and positive control groups. Among the groups of comparative examples 1 to 3, the average litter size of the group 3 sows of which the fermentation treatment was not performed was the lowest, suggesting that the fermentation treatment may have a higher influence on the efficacy of the Chinese medicinal composition of the present invention, and the average litter size of the group 1 to 2 sows of the comparative examples was also lower than that of the group 1 to 2, suggesting that the formulation of the Chinese medicinal composition of the present invention may have an important influence on the efficacy thereof, and that the efficacy may be affected to a different extent after omitting a part of the medicinal flavor or replacing it with another medicinal flavor.
3.3 weaning weight of piglets of each group for 25 days
The weight of the piglets can reflect the health condition of the piglets and indirectly the overall health state of the sows. During the experiment, the weight of piglets of the same day of age in each administration group (especially in the examples 1-2) is different to a greater extent than that of the blank control group, and the piglets of the administration group are generally plump in appearance and moist in hair color, while the piglets of the blank control group are sunken in the rib parts, and the overall mental condition is poor.
The experimental results are shown in table 1. Experimental results show that the weaning weights of piglets in each experimental group are different from those in a blank control group in 25 days. Of these, the piglets of example 1 and example 2 had the highest weaning weight for 25 days, significantly higher than the comparison 1-3 and positive control. Of the groups of comparative examples 1 to 3, the group 3 in which the piglets were not subjected to the fermentation treatment had the lowest weaning weight for 25 days and were only slightly higher than the blank group, and the results suggested that the fermentation treatment may have a higher effect on the efficacy of the Chinese medicinal composition of the present invention, and that the group 1 to 2 in which the piglets were subjected to the fermentation treatment had a lower weaning weight for 25 days than the group 1 to 2 in which the formulation of the Chinese medicinal composition of the present invention had a significant effect on the efficacy, and that the efficacy could be affected to a different extent when a part of the taste was omitted or replaced with another taste.
3.4 oestrus rate in 7 days for sows of each group
The number of non-production days of the sow is closely related to the profitability of the pig farm, and the problem has greater influence on a large pig farm. Therefore, the oestrus condition of the sow within 7 days after weaning directly represents the health state of the sow and the profitability of the pig farm.
The experimental results are shown in table 1. The experimental results show that the oestrus rate of each experimental group of sows is higher than that of the blank control group in different degrees within 7 days after weaning. The highest oestrus rate within 7 days after weaning of the sows in the example 1 group and the example 2 group is 100%, which is obviously higher than that of the sows in the comparative examples 1-3 and the positive control group. Of the groups of comparative examples 1 to 3, the sow of comparative example 3, in which the fermentation treatment was not performed, had the lowest oestrus rate (62.5%) within 7 days after weaning, but was slightly higher than that of the positive control group (50%), which suggested that the fermentation treatment may have a higher effect on the efficacy of the Chinese medicinal composition of the present invention, and that the sow of comparative example 1 to 2 had a lower oestrus rate within 7 days after weaning than that of the sow of example 1 to 2, which suggested that the formulation of the Chinese medicinal composition of the present invention also had an important effect on the efficacy thereof, and that it may have a different degree of effect on the efficacy when omitting a part of the drug flavor or replacing it with another drug flavor.
3.4 feeding of the sows of each group
The feeding amount of the sow is directly related to the milk of the sow, the lactation fat condition of the sow, the postweaning oestrus and the like. The test is carried out in summer, and at this time, most pig farms have the problem of low feed intake of pig groups.
The experimental results are shown in table 1. Experimental results show that the feed intake of the sows in each experimental group is higher than that of the blank control group. Wherein, the feeding amount of the sow in the example 1 group and the sow in the example 2 group is highest, which is obviously higher than that of the sow in the comparative examples 1-3 group and the positive control group. Of the groups of comparative examples 1 to 3, the group of comparative example 3, in which the fermentation treatment was not performed, had the lowest intake of sow, and the result suggested that the fermentation treatment may have a higher influence on the efficacy of the Chinese medicinal composition of the present invention, and the intake of sow of the group of comparative examples 1 to 2 was also lower than that of the group of examples 1 to 2, suggesting that the formulation of the Chinese medicinal composition of the present invention may have an important influence on the efficacy thereof, and that it may have a different degree of influence on the efficacy when a part of the taste was omitted or replaced with another taste.
3.5 sub-health symptomatic improvement of sows in groups
The experimental results are shown in table 1. Experimental results show that the sub-health symptom improvement condition of each experimental group of sows is better than that of a blank control group to different degrees. Among them, the sub-health symptoms of the sows in the group of the example 1 and the group of the example 2 are improved by 100%, the skin of all sows is recovered to be light red, tear spots and swelling bags are eliminated, or the skin color is resolved, the tear spots and swelling bags are reduced, and the experimental results are obviously better than those of the groups of the comparative examples 1-3 and the positive control group. Among the groups of comparative examples 1 to 3, the improvement of sub-health conditions of the sows of the group 3, in which the fermentation treatment was not performed, was most undesirable, and the results suggest that the fermentation treatment may have a higher effect on the efficacy of the Chinese medicinal composition of the present invention, and that the improvement of sub-health conditions of the sows of the group 1 to 2 is also inferior to that of the group 1 to 2, suggesting that the formulation of the Chinese medicinal composition of the present invention may have an important effect on the efficacy thereof, and that the efficacy may be affected to a different extent after omitting a part of the medicinal taste or replacing it with another medicinal taste.
Table 1: the invention relates to an effect of a traditional Chinese medicine composition in improving sub-health of sows
Note that: sub-health symptom improvement includes total number of animals with significantly improved and improved sub-health symptoms, wherein "significantly improved" refers to recovery of the sow skin from redness, removal of tear stains and swelling. "improvement" refers to a reduction in the color of the sow's skin, tear spots and swelling. The sub-health state refers to the white or yellowish skin of the sow, with the spots and swelling of tears.
In conclusion, the traditional Chinese medicine composition and the fermented traditional Chinese medicine preparation can comprehensively improve the sub-health state of sows, and improve the health degree of sows, so that the breeding rate of the replacement sows is improved, the two-embryo syndrome of the sows is obviously reduced, the tear-spot swelling of the multiparous sows is eliminated, the skin is recovered to be light red, the sub-health state of the sows is eliminated, the oestrus and the breeding of the sows are recovered to be normal, and the elimination rate of the sows is reduced. Moreover, during the whole experiment period, no toxic or side effect of the traditional Chinese medicine composition and the fermented traditional Chinese medicine preparation is observed in experimental sows.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (7)
1. A traditional Chinese medicine composition for improving sub-health of sows is characterized in that: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 30 parts of polygonum cuspidatum, 20 parts of water chestnut, 10 parts of honeysuckle stem, 10 parts of white paeony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of angelica, 1 part of red-rooted salvia root, 2 parts of astragalus root, 2 parts of eclipta alba, 5 parts of bupleurum, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn fruit, 2 parts of organic yeast selenium,
the preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) Weighing the raw materials according to the weight ratio, mixing the rest raw materials except the organic yeast selenium, and crushing into coarse powder;
(2) Adding 8 times of water into the coarse powder, extracting at 50 ℃ for 3 hours, and transferring to a fermentation tank;
(3) Adding white sugar 0.5 times of the total weight of the above raw materials except organic yeast selenium, stirring, cooling to 35deg.C, adding yeast 0.07% of the total weight of the above raw materials, fermenting for 7 days, fermenting with 200 mesh filter cloth, and filtering to obtain fermentation broth;
(4) Vacuum freeze drying the fermentation broth to powder;
(5) And then crushing the dried materials, adding organic yeast selenium, and mixing for 20 minutes to obtain the traditional Chinese medicine composition.
2. A traditional Chinese medicine composition for improving sub-health of sows is characterized in that: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 parts of silybum marianum, 30 parts of polygonum cuspidatum, 30 parts of water chestnut, 15 parts of honeysuckle stem, 5 parts of white paeony root, 10 parts of gynostemma pentaphylla, 10 parts of liquorice, 5 parts of codonopsis pilosula, 8 parts of bighead atractylodes rhizome, 10 parts of angelica, 5 parts of red sage root, 5 parts of astragalus membranaceus, 5 parts of eclipta alba, 3 parts of radix bupleuri, 3 parts of poria cocos, 3 parts of dried orange peel, 5 parts of fried hawthorn and 5 parts of organic yeast selenium,
the preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) Weighing the raw materials according to the weight ratio, mixing the rest raw materials except the organic yeast selenium, and crushing into coarse powder;
(2) Adding 10 times of water into the coarse powder, extracting at 60 ℃ for 2 hours, and transferring to a fermentation tank;
(3) Adding white sugar 1 times of the total weight of the above raw materials except organic yeast selenium, stirring, cooling to 35deg.C, adding yeast 0.1% of the total weight of the above raw materials, fermenting for 7 days, fermenting with 200 mesh filter cloth, and filtering to obtain fermentation broth;
(4) Vacuum freeze drying the fermentation broth to powder;
(5) And then crushing the dried materials, adding organic yeast selenium, and mixing for 20 minutes to obtain the traditional Chinese medicine composition.
3. A fermented traditional Chinese medicine preparation for improving sub-health of sows is characterized in that: the fermented traditional Chinese medicine preparation comprises the traditional Chinese medicine composition of claim 1 or claim 2.
4. Use of the traditional Chinese medicine composition according to claim 1 or claim 2 or the fermented traditional Chinese medicine preparation according to claim 3 for preparing a medicament for improving sub-health of sows.
5. Use according to claim 4, characterized in that: the application is to improve the breeding rate of the replacement gilts, reduce the two-embryo syndrome of the gilts, eliminate the lacrimal spot swelling of the multiparous gilts, restore the skin to be light red, eliminate the sub-health state of the gilts, restore the oestrus and the mating of the gilts to be normal, and reduce the elimination rate of the gilts.
6. Use of the traditional Chinese medicine composition according to claim 1 or claim 2 or the fermented traditional Chinese medicine preparation according to claim 3 for preparing feed for improving sub-health of sows.
7. Use according to claim 6, characterized in that: the traditional Chinese medicine composition or the fermented traditional Chinese medicine preparation is added into the feed in a weight percentage of 0.05% -0.5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211423676.2A CN115969909B (en) | 2022-11-15 | 2022-11-15 | Traditional Chinese medicine composition and fermented traditional Chinese medicine preparation for improving sub-health of sow as well as preparation method and application of traditional Chinese medicine composition and fermented traditional Chinese medicine preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211423676.2A CN115969909B (en) | 2022-11-15 | 2022-11-15 | Traditional Chinese medicine composition and fermented traditional Chinese medicine preparation for improving sub-health of sow as well as preparation method and application of traditional Chinese medicine composition and fermented traditional Chinese medicine preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115969909A CN115969909A (en) | 2023-04-18 |
| CN115969909B true CN115969909B (en) | 2023-12-08 |
Family
ID=85971130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211423676.2A Active CN115969909B (en) | 2022-11-15 | 2022-11-15 | Traditional Chinese medicine composition and fermented traditional Chinese medicine preparation for improving sub-health of sow as well as preparation method and application of traditional Chinese medicine composition and fermented traditional Chinese medicine preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115969909B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116966230B (en) * | 2023-09-11 | 2024-04-19 | 山东利邦牧业股份有限公司 | Fermented traditional Chinese medicine composition for preventing and controlling porcine reproductive and respiratory syndrome as well as preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109589361A (en) * | 2017-09-30 | 2019-04-09 | 河南牧动物药业有限公司 | A kind of Chinese medicine composition for improving sow fertility rate, Chinese materia medica preparation and preparation method thereof |
| CN114848763A (en) * | 2022-03-25 | 2022-08-05 | 河南牧业经济学院 | Traditional Chinese medicine composition for sows in gestation period and/or lactation period, fermented traditional Chinese medicine preparation and preparation method thereof |
-
2022
- 2022-11-15 CN CN202211423676.2A patent/CN115969909B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109589361A (en) * | 2017-09-30 | 2019-04-09 | 河南牧动物药业有限公司 | A kind of Chinese medicine composition for improving sow fertility rate, Chinese materia medica preparation and preparation method thereof |
| CN114848763A (en) * | 2022-03-25 | 2022-08-05 | 河南牧业经济学院 | Traditional Chinese medicine composition for sows in gestation period and/or lactation period, fermented traditional Chinese medicine preparation and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 加味逍遥散对肝郁脾虚型亚健康状态的干预治疗;梁国平;;深圳中西医结合杂志;-;第19卷(第05期);第303-304，311页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115969909A (en) | 2023-04-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101787432B1 (en) | Method for manufacturing oriental medicine composition which improves menorrhagia and dysmenorrhea comprising fermented velvet antler and yeast hydrolysate | |
| CN102178100B (en) | Low-tryptophan feed for hybrid chicken and preparation method of the low-tryptophan feed | |
| CN104472913A (en) | Application of Chinese medicinal herb layer feed additive | |
| CN104161187B (en) | A kind of poultry Chinese herbal feed additive, preparation method and application | |
| CN104173436A (en) | Compound traditional Chinese medicinal composition for cows, and preparation method and application thereof | |
| CN103734426B (en) | A kind of Fructus Corni health protection tea of improving immunity and preparation method thereof | |
| CN104431498A (en) | Chinese herbal medicine laying hen feed additive and preparation method thereof | |
| CN110384732B (en) | Traditional Chinese medicine composition, traditional Chinese medicine microecological preparation, and preparation method and application thereof | |
| CN104472914A (en) | Laying hen feed containing Chinese herbal medicine additive and preparation method thereof | |
| CN108338258A (en) | A kind of farrowing sow Synbiotic feed additive and preparation method and application | |
| CN115969909B (en) | Traditional Chinese medicine composition and fermented traditional Chinese medicine preparation for improving sub-health of sow as well as preparation method and application of traditional Chinese medicine composition and fermented traditional Chinese medicine preparation | |
| KR20160119999A (en) | Gongjindan based on dongibogam and method of manufacturing the same | |
| CN104826022A (en) | Traditional Chinese medicine for treating hyperplasia of mammary glands | |
| CN104208339A (en) | Traditional Chinese medicine composition for treating livestock and poultry bacterial or viral diseases and preparation method thereof | |
| CN114848763B (en) | Traditional Chinese medicine composition for sow gestation period and/or lactation period, fermented traditional Chinese medicine preparation and preparation method thereof | |
| CN105918658A (en) | Sheep feed for treating diarrhoea | |
| CN108783432A (en) | Health food and preparation method thereof with antitumaous effect | |
| CN104431359A (en) | Rearing method of laying hens | |
| CN108617853A (en) | The feed addictive and preparation method for promoting chick growth, improving laying rate of laying hen | |
| CN114099626A (en) | Multifunctional composition for human body health care and preparation method and application thereof | |
| CN112868937A (en) | Chicken feed for improving disease resistance and survival rate, preparation method and feeding method thereof | |
| CN105941953A (en) | Feed additive for raising cavies | |
| CN105327147A (en) | Medicine composition for treating swine enzootic pneumonia and preparation method thereof | |
| CN109646665A (en) | Cortex Eucommiae clearing lung-heat anticancer solid tea and preparation method thereof | |
| CN114344434B (en) | Traditional Chinese medicine composition for treating pulmonary nodules and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |