CN115919318A - Measuring system and measuring method for biological magnetic field - Google Patents
Measuring system and measuring method for biological magnetic field Download PDFInfo
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Abstract
The invention discloses a measuring system and a measuring method of a biological magnetic field. The system comprises an objective table, a field stabilization magnetometer module, a measurement magnetometer module, a field stabilization coil module, a feedback control module and a data processing module; wherein, the objective table is used for placing the organism to be detected; the field stabilizing magnetometer module is used for measuring the environmental magnetic field in the field stabilizing coil module and inputting a measurement signal to the feedback control module and the data processing module in real time; the feedback control module is used for adjusting the current input to the field stabilizing coil module in real time according to the measurement signal; the field stabilizing coil module is used for generating a compensation magnetic field for eliminating an environmental magnetic field; the measuring magnetometer module is used for measuring the total magnetic field in the field stabilizing coil module and sending the total magnetic field to the data processing module; and the data processing module is used for performing difference operation on the measurement signal of the measurement magnetometer module and the measurement signal of the steady field magnetometer module to obtain the biological magnetic field of the to-be-measured organism. The invention can realize the measurement of the biological magnetic field under the condition of no magnetic shielding.
Description
Technical Field
The invention belongs to the technical field of magnetic field measurement, and particularly relates to a measuring system and a measuring method for a biological magnetic field.
Background
The measurement of biological magnetic fields has important value in clinical and scientific applications. For example, the magnetoencephalogram has important application value in diagnosis of epilepsy and positioning of focus, and plays an important role in research on brain structure and function; the magnetocardiogram has important application value in early diagnosis of coronary heart disease and plays an important role in the research of heart structure and function; the gastrointestinal magnetic map has important application value in the detection of electrophysiological abnormalities such as gastrointestinal slow wave disorders, and plays an important role in the research of the electrophysiological properties of the gastrointestinal tract.
In order to measure the biological magnetic field, researchers at home and abroad design different biological magnetic field measuring systems. The structure of the biological magnetic field measured by the superconducting quantum interference magnetometer in the magnetic shielding room is complex, the construction and use cost is high, and the measured object is single; the unshielded measuring system based on the atomic magnetometer has extremely strict requirements on the environmental magnetic field condition, low sensitivity and single measuring object. For this reason, these existing biomagnetic field measurement systems are not advantageous for the application of biomagnetic fields in the medical field and the scientific research of biomagnetic fields.
Laboratory animals are indispensable experimental materials in biological research, especially in physiological experiments. Different pathological models or mutant species can be flexibly constructed by applying experimental animals to carry out experiments, the number of experimental samples is sufficient, the experimental conditions are controllable and rich, the ethical risk is small, and the experimental data obtained in the research of the mammals have guiding significance for human experiments and final application. The measurement of the biological magnetic field also needs to be started from the measurement of the animal magnetic field, the experiment for measuring the animal magnetic field can be used for testing the reliability of the experimental device and the experimental method, the improvement direction of the experimental device and the experimental method is provided, rules can be summarized from obtained data, and the application of the biological magnetic field in clinic and scientific research is finally guided.
Disclosure of Invention
In view of the problems in the prior art, the present invention aims to provide a measuring system and a measuring method for a biological magnetic field.
The system at least comprises an objective table, a field stabilizing magnetometer module, a measuring magnetometer module, a field stabilizing coil module, a feedback control module and a data acquisition module, and can also comprise a data processing module and a position adjusting module according to experimental needs.
Anaesthetizing the experimental animal and placing the experimental animal on an objective table; adjusting the position of the measuring magnetometer module to a specific position relative to the experimental animal to be measured; the field stabilizing magnetometer module measures the environmental magnetic field in the field stabilizing coil module and inputs a measurement signal to the feedback control module in real time; the feedback control module adjusts the current input to the field stabilizing coil module in real time; the field stabilizing coil module generates a compensation magnetic field which has the same size and the opposite direction with the environmental magnetic field fluctuation in real time, so that a stable magnetic field in a certain area is generated in the field stabilizing coil module; the measuring magnetometer module measures the total magnetic field obtained by adding the environmental magnetic field and the biological magnetic field in the field stabilizing coil module; and performing difference operation on the measurement signal of the measurement magnetometer module and the measurement signal of the steady field magnetometer module to obtain the biological magnetic field at the specific position generated by the experimental animal.
Wherein the content of the first and second substances,
in the formula>
For the biomagnetic field obtained by the difference operation, <' >>
For measuring the magnetic field measured by the magnetometer module, in combination with a magnetic field sensor>
The magnetic field is measured by the stable field magnetometer module. />
The invention has the advantages that:
the measuring system for the biological magnetic field of the experimental animal designed by the invention can realize the measurement of the biological magnetic field of the experimental animal under the condition of no magnetic shielding, has simple structure, easy operation and high accuracy, and is suitable for measuring and analyzing the biological magnetic field in units such as hospitals, laboratories and the like.
Drawings
FIG. 1 is a biological magnetic field measuring system proposed in the present invention;
fig. 2 shows a steady-field magnetometer module, a measurement magnetometer module, an experimental animal placement module, a data acquisition module, a data processing module, a feedback adjustment module, and the positional relationship therebetween in embodiment 1;
fig. 3 is a field stabilizing coil module in example 1 and example 2;
fig. 4 is a position adjusting module in embodiment 1;
fig. 5 shows a steady field magnetometer module, a measurement magnetometer module, an experimental animal placement module, a data acquisition module, a data processing module, a feedback adjustment module, and the positional relationship therebetween in embodiment 2.
Detailed Description
The invention will be described in further detail with reference to the drawings, which are given by way of example only for the purpose of illustrating the invention and not for the purpose of limiting the scope of the invention.
The biological magnetic field measurement system of the invention is shown in figure 1, and comprises an experimental animal placing module 1, a field stabilizing magnetometer module 2, a measurement magnetometer module 3, a field stabilizing coil module 4, a feedback control module 5, a data acquisition module 6, and a data processing module 7 and a position adjusting module 8 according to experimental requirements.
When measuring the biological magnetic field, anaesthetizing the experimental animal and placing the animal in the experimental animal placing module 1; the position of the measuring magnetometer module 3 is adjusted to a position to be detected relative to the experimental animal to be detected through the position adjusting module 8; the field stabilizing magnetometer module 2 measures the environmental magnetic field in the field stabilizing coil module 4 and inputs the measurement signal to the feedback control module 5 in real time; the feedback control module 5 adjusts the current input to the field stabilizing coil module 4 in real time; the field stabilizing coil module 4 generates a compensation magnetic field which has the same size with the environmental magnetic field fluctuation but opposite direction in real time, so that a stable magnetic field in a certain area is generated in the field stabilizing coil module 4; the measuring magnetometer module 3 measures the total magnetic field obtained by adding the environmental magnetic field and the biological magnetic field in the field stabilizing coil module 4; and performing difference operation on the measurement signal of the measurement magnetometer module 3 and the measurement signal of the steady field magnetometer module 2 to obtain the biological magnetic field of the position to be detected, which is generated by the experimental animal.
The experimental animal placing module 1 is used for placing an experimental animal which generates a biological magnetic field to be measured. When the biological magnetic field is measured, the animal to be measured is anesthetized, and the animal is placed in the experimental animal placing module 1 and fixed according to the body type of the experimental animal and the generation position of the biological magnetic field to be measured.
The stable field magnetometer module 2 can adopt an atomic magnetometer, a superconducting quantum interference magnetometer, a coil magnetometer, a fluxgate magnetometer, a giant magnetoresistance magnetometer or a combination of the magnetometers. When the biological magnetic field is measured, the field stabilizing magnetometer module 2 measures the environmental magnetic field in the field stabilizing coil module 4, and inputs the measurement signal to the feedback control module 5 and the data acquisition module 6 in real time.
The measurement magnetometer module 3 may employ an atomic magnetometer, a superconducting quantum interference magnetometer, a coil magnetometer, a fluxgate magnetometer, a giant magnetoresistance magnetometer, or a combination thereof. When measuring the biological magnetic field, the measuring magnetometer module 3 measures the total magnetic field obtained by adding the environmental magnetic field and the biological magnetic field in the field stabilizing coil module 4, and inputs the measurement signal to the data acquisition module 6 in real time.
The field stabilizing coil module 4 may employ a helmholtz coil, a combination of helmholtz coils, or a solenoid. The Helmholtz coil comprises a single-shaft circular Helmholtz coil, a double-shaft circular Helmholtz coil, a three-shaft circular Helmholtz coil, a single-shaft square Helmholtz coil, a double-shaft square Helmholtz coil or a three-shaft square Helmholtz coil. When the biological magnetic field is measured, the field stabilizing coil module 4 receives the current input by the feedback control module 5, and generates a compensation magnetic field with the same size and the opposite direction to the environmental magnetic field fluctuation in real time, so that a stable magnetic field in a certain area is generated in the field stabilizing coil module 4.
The feedback control module 5 may employ a pid circuit module. When the biological magnetic field is measured, the feedback control module 5 outputs a current which enables the field stabilization coil module 4 to generate a compensation magnetic field with the same size and the opposite direction of the environmental magnetic field fluctuation in real time to the field stabilization coil module 4 according to the signal input by the field stabilization magnetometer module 2.
The data acquisition module 6 can adopt an acquisition card, an industrial personal computer, a single chip microcomputer, a computer, a server or a combination of the above devices. When the biological magnetic field is measured, the data acquisition module 6 is used for acquiring the output signal of the measurement magnetometer module 3, the output signal of the field stabilization magnetometer module 2 and/or the difference signal between the output signal of the measurement magnetometer module 3 and the output signal of the field stabilization magnetometer module 2 and storing the difference signal on a data carrier in a preset format.
The data processing module 7 can adopt an industrial personal computer, a single chip microcomputer, a computer, a server or a combination of the above devices. When measuring the biological magnetic field, the data processing module 7 acquires and processes the data recorded by the data acquisition module 6.
The position adjusting module 8 comprises a pulley, a guide rail, a fixed rod, a graduated scale and a combination of the above facilities. When measuring the biological magnetic field, the position adjusting module 8 is used for adjusting the position of the measuring magnetometer module 3 relative to the experimental animal generating the magnetic field to be measured.
Example 1
The stable field magnetometer module, the measurement magnetometer module, the experimental animal placing module, the data acquisition module, the data processing module and the feedback adjusting module and the position relation among the stable field magnetometer module, the measurement magnetometer module, the experimental animal placing module, the data acquisition module, the data processing module and the feedback adjusting module are shown in figure 2.
Example 1 is an experimental rabbit gastrointestinal magnetic field measurement system based on a three-dimensional helmholtz coil combination and amplitude modulation nonlinear magneto-optical rotary magnetometer (AM-NMOR magnetometer).
In this embodiment 1, the field-stabilized magnetometer module 2 and the measurement magnetometer module 3 employ a combination 21 of two AM-NMOR magnetometers. An AM-NMOR magnetometer is a high sensitivity atomic magnetometer that operates under a limited magnetic field. The combination 21 of two AM-NMOR magnetometers is placed in the central area of the field stabilizing coil module 4 at a distance in the vertical direction, wherein the upper AM-NMOR magnetometer 211 serves as the field stabilizing magnetometer module 2; the upper AM-NMOR magnetometer 211 and the lower AM-NMOR magnetometer 212 together form a measurement magnetometer module 3 to achieve measurement of the bio-magnetic field.
In the present embodiment, the field stabilizing coil module 4 employs a three-dimensional helmholtz coil assembly 41 as shown in fig. 3. The three-dimensional helmholtz coil assembly 41 includes two layers of three-dimensional field-stabilizing coils 411 and three-dimensional compensation coils 412, which are coaxial respectively. The three-dimensional field stabilizing coil 411 includes a first helmholtz field stabilizing coil 4111 oriented vertically, a second helmholtz field stabilizing coil 4112 oriented east and west, and a third helmholtz field stabilizing coil 4113 oriented north and south; the three-dimensional compensation coil 412 includes a first helmholtz compensation coil 4121 in the vertical direction, a second helmholtz compensation coil 4122 in the east-west direction, and a third helmholtz compensation coil 4123 in the north-south direction, which are coaxial with the helmholtz steady field coil, respectively.
In the present embodiment, the position adjustment module 8 includes two north-south horizontal rails 81 fixed to the coil, a east-west horizontal rail 82 slidably mounted on the north-south horizontal rails, and a magnetometer fixing module 83 including a vertical fixing rod 831 slidably mounted on the east-west horizontal rail slidably mounted on the north-south horizontal rails, and a magnetometer fixing platform 832 fixed to the lower end of the fixing rod.
In the present embodiment, the feedback adjusting module 5 is a pid/integrator circuit module 51.
In this embodiment, the experimental animal placing module 1 is located at a proper position below the combination of two AM-NMOR magnetometers in the three-dimensional helmholtz coil, and comprises an experimental animal height adjusting device 11 and a rabbit dissecting plate 12. Wherein the experimental animal height adjusting device 11 adopts a jack structure.
In this embodiment, the data acquisition module 6 includes a data acquisition card 61 and a computer 62. The measured data of the two AM-NMOR magnetometers 21 are transmitted to the data acquisition card 61 via data lines, converted into digital signals by the data acquisition card 61 and then transmitted to the computer 62. The computer 62 is internally provided with a data processing module 71, and the gradient signal of the vertical biological magnetic field for eliminating the common mode noise is obtained by subtracting the measurement data of the lower layer AM-NMOR magnetometer 212 from the measurement data of the upper layer AM-NMOR magnetometer 211.
In this embodiment, when measuring the gastrointestinal magnetic field of a laboratory rabbit, the current in the three-dimensional bucking coil 412 in the field-stabilizing coil module 4 is adjusted to direct the main magnetic field vertically upward.
In this embodiment, when measuring the gastrointestinal magnetic field of the experimental rabbit, the AM-NMOR magnetometer 211 at the upper layer measures the ambient magnetic field in the vertical direction in the three-dimensional helmholtz coil assembly 41 and inputs a signal to the proportional-differential-integration circuit module 51, and the proportional-differential-integration circuit module 51 adjusts the current input to the first helmholtz field-stabilizing coil 4111 in real time according to the fluctuation of the magnetic field, so that the magnetic field in the vertical direction generated by the first helmholtz field-stabilizing coil 4111 and the fluctuation of the magnetic field in the vertical direction in the three-dimensional field-stabilizing coil 411 cancel each other, so as to reduce the fluctuation of the magnetic field in the vertical direction of the AM-NOMR magnetometer, thereby maintaining the stable ambient magnetic field in the vertical direction.
In this embodiment, when measuring the gastrointestinal magnetic field of the experimental rabbit, injecting a proper amount of anesthetic according to the body weight of the experimental rabbit to anesthetize the experimental rabbit, fixing the abdominal surface of the experimental rabbit on the rabbit anatomical plate 12 of the experimental animal placing module 1, and adjusting the abdominal surface of the experimental rabbit to the central position in the field stabilizing coil module 4 by using the experimental animal height adjusting device 11. The measurement can be performed by adjusting the position adjustment module 8 to the stationary field magnetometer module 2 and the measurement magnetometer module 3 to the respective measurement positions.
Example 2
The stable field magnetometer module, the measurement magnetometer module, the experimental animal placing module, the data acquisition module, the data processing module and the feedback adjusting module and the position relation among the modules are shown in figure 5.
Example 2 is a rat magnetocardiography system based on a three-dimensional helmholtz coil assembly and amplitude modulated nonlinear magneto-optical rotating magnetometer (AM-NMOR magnetometer).
In this embodiment, the field-stabilized magnetometer module 2 and the measurement magnetometer module 3 employ a combination 22 of two AM-NMOR magnetometers. An AM-NMOR magnetometer is a high sensitivity atomic magnetometer that operates under a limited magnetic field. The combination 22 of the two AM-NMOR magnetometers is arranged in the central area of the field stabilizing coil module 4 and is arranged at a certain distance in the vertical direction, wherein the lower AM-NMOR magnetometer 221 is used as the field stabilizing magnetometer module 2; the upper AM-NMOR magnetometer 222 and the lower AM-NMOR magnetometer 221 together form a measurement magnetometer module 3 to achieve measurement of the biological magnetic field.
In the present embodiment, the field stabilizing coil module 4 is a three-dimensional helmholtz coil assembly 41. The three-dimensional helmholtz coil assembly 41 includes two layers of three-dimensional field-stabilizing coils 411 and three-dimensional compensation coils 412, which are coaxial respectively. The three-dimensional field stabilizing coil 411 includes a first helmholtz field stabilizing coil 4111 oriented vertically, a second helmholtz field stabilizing coil 4112 oriented east and west, and a third helmholtz field stabilizing coil 4113 oriented north and south; the three-dimensional compensation coil 412 includes a first helmholtz compensation coil 4121 in the vertical direction, a second helmholtz compensation coil 4122 in the east-west direction, and a third helmholtz compensation coil 4123 in the north-south direction, which are coaxial with the helmholtz steady field coil, respectively.
In the present embodiment, the feedback adjusting module 5 is a pid/integrator circuit module 51.
In the present embodiment, the experimental animal housing module 1 includes the heat insulating film 13.
In this embodiment, the data acquisition module 6 includes a data acquisition card 61 and a computer 62. The measured data of the two AM-NMOR magnetometers are transmitted to the data acquisition card 61 through a data line, converted into digital signals through the data acquisition card 61 and then transmitted to the computer 62. The data processing module 72 is arranged in the computer, and the measurement data of the AM-NMOR magnetometer 222 on the upper layer and the measurement data of the AM-NMOR magnetometer 221 on the lower layer are subtracted to obtain a gradient signal of the biological magnetic field in the vertical direction for eliminating the common mode noise.
In this embodiment, when measuring rat magnetocardiogram, the current in the three-dimensional bucking coils 412 in the field stabilizing coil module 4 is adjusted to direct the main magnetic field vertically upward.
In this embodiment, when measuring rat magnetocardiogram, the lower AM-NMOR magnetometer 221 measures an ambient magnetic field in the vertical direction in the three-dimensional helmholtz coil assembly 41 and inputs a signal to the pid module, and the pid module 51 adjusts the current input to the first helmholtz field stabilizing coil 4111 in real time according to the fluctuation of the magnetic field, so that the vertical magnetic field generated by the first helmholtz field stabilizing coil 4111 and the vertical magnetic field fluctuation in the three-dimensional field stabilizing coil 411 cancel each other out, so as to reduce the magnetic field fluctuation in the vertical direction of the AM-NOMR magnetometer, thereby maintaining a stable ambient magnetic field in the vertical direction.
In this example, the thermally insulating film was overlaid on a combination of two AM-NMOR magnetometers 22 while measuring the magnetic field of the rat heart. The rats are anesthetized by injecting a proper amount of anesthetic into the rats according to the body weights of the rats, and the anesthetized rats are placed on the heat insulation film 13 with the ventral surfaces facing downwards. The measurement can be performed by adjusting the placement position of the rat so that the heart region is above the probe of the measuring magnetometer.
The measuring method comprises the following steps:
the method for measuring the biological magnetic field by the measuring system comprises the following steps:
(1) Anaesthetizing the experimental animal and placing the experimental animal in an experimental animal placing module;
(2) Adjusting the position of the measuring magnetometer module to a specific position relative to the experimental animal to be measured;
(3) The field stabilizing magnetometer module measures the environmental magnetic field in the field stabilizing coil module and inputs a measurement signal to the feedback control module in real time;
(4) The feedback control module adjusts the current input to the field stabilizing coil module in real time;
(5) The field stabilizing coil module generates a compensation magnetic field which has the same size and the opposite direction with the environmental magnetic field fluctuation in real time, so that a stable magnetic field in a certain area is generated in the field stabilizing coil module;
(6) The measuring magnetometer module measures the total magnetic field obtained by adding the magnetic field and the biological magnetic field in the field stabilizing coil module;
(7) And performing difference operation on the measurement signal of the measurement magnetometer module and the measurement signal of the steady field magnetometer module to obtain the biological magnetic field at the specific position generated by the experimental animal.
Although specific embodiments of the invention have been disclosed for purposes of illustration, and for purposes of aiding in the understanding of the contents of the invention and its implementation, those skilled in the art will appreciate that: various substitutions, changes and modifications are possible without departing from the spirit and scope of the present invention and the appended claims. Therefore, it is intended that the invention not be limited to the particular embodiment disclosed as the best mode contemplated for carrying out this invention, but that the invention will include all embodiments falling within the scope of the appended claims.
Claims (10)
1.A measuring system of a biological magnetic field is characterized by comprising an objective table, a stable field magnetometer module, a measuring magnetometer module, a stable field coil module, a feedback control module and a data processing module; the objective table, the field stabilizing magnetometer module and the measuring magnetometer module are positioned inside the field stabilizing coil module;
the object stage is used for placing a to-be-detected organism;
the field stabilization magnetometer module is used for measuring the environmental magnetic field in the field stabilization coil module and inputting a measurement signal to the feedback control module and the data processing module in real time;
the feedback control module is used for adjusting the current input to the field stabilizing coil module in real time according to the measurement signal;
the field stabilizing coil module is used for generating a compensation magnetic field for eliminating the environmental magnetic field;
the measuring magnetometer module is used for measuring the total magnetic field in the field stabilizing coil module and sending the total magnetic field to the data processing module; the total magnetic field comprises the environmental magnetic field and a biological magnetic field generated by the organism to be detected;
and the data processing module is used for performing difference operation on the measurement signal of the measurement magnetometer module and the measurement signal of the steady field magnetometer module to obtain the biological magnetic field of the to-be-measured organism.
2. The measurement system of claim 1, further comprising a position adjustment module within the shimming coil module for adjusting the position of the measurement magnetometer module to a position to be detected relative to the living being to be detected.
3. The measuring system of claim 2, wherein the position adjusting module comprises two horizontal guide rails (81) fixed on the field stabilizing coil module, a second horizontal guide rail (82) vertically arranged on the two horizontal guide rails (81) and capable of freely sliding, and a magnetometer fixing module (83) vertically arranged on the second horizontal guide rail (82); the magnetometer fixing module (83) comprises a vertical fixing rod (831) and a magnetometer fixing platform (832); the upper end of the vertical fixing rod (831) is connected with the second horizontal guide rail (82) and can freely slide along the second horizontal guide rail (82), and the lower end of the vertical fixing rod (831) is connected and fixed with a magnetometer fixing platform (832); the measurement magnetometer module is fixed to the magnetometer mount platform (832).
4. A measurement system according to claim 1, 2 or 3, wherein the measurement magnetometer module is an atomic magnetometer, a superconducting quantum interference magnetometer, a coil magnetometer, a flux gate magnetometer, a giant magneto-resistance magnetometer or a combination thereof.
5. The measurement system of claim 1, 2 or 3, wherein the steady field magnetometer module is an atomic magnetometer, a superconducting quantum interference magnetometer, a coil magnetometer, a flux gate magnetometer, a giant magnetoresistance magnetometer, or a combination thereof.
6. The measurement system of claim 1, 2 or 3, wherein the field-stabilizing coil module is a Helmholtz coil, a combination of Helmholtz coils, or a solenoid; the Helmholtz coil comprises a single-shaft circular Helmholtz coil, a double-shaft circular Helmholtz coil, a three-shaft circular Helmholtz coil, a single-shaft square Helmholtz coil, a double-shaft square Helmholtz coil or a three-shaft square Helmholtz coil.
7. A measurement system according to claim 1, 2 or 3, further comprising a data acquisition module; and the measurement signal of the measurement magnetometer module and the measurement signal of the stable field magnetometer module are respectively input to the data processing module through the data acquisition module.
8. A method for measuring a biological magnetic field, comprising the steps of:
1) The object stage, the field stabilizing magnetometer module and the measuring magnetometer module are arranged in the field stabilizing coil module;
2) Placing a to-be-detected organism on the objective table; placing the measuring magnetometer module at a detection position relative to the to-be-detected living being and a data processing module;
3) Measuring the environmental magnetic field in the field stabilizing coil module by using the field stabilizing magnetometer module, and inputting a measurement signal to the feedback control module in real time;
4) The feedback control module adjusts the current input to the field stabilizing coil module in real time according to the received measuring signal;
5) The field stabilizing coil module generates a compensation magnetic field which has the same size and the opposite direction with the environmental magnetic field fluctuation in real time;
6) The measuring magnetometer module measures the total magnetic field in the field stabilizing coil module and sends the total magnetic field to the data processing module; the total magnetic field comprises the environmental magnetic field and a biological magnetic field generated by the organism to be detected;
7) And the data processing module performs difference operation on the measurement signal of the measurement magnetometer module and the measurement signal of the steady field magnetometer module to obtain the biological magnetic field of the to-be-measured organism.
9. The method of claim 8, further comprising a position adjustment module within the shimming coil module for adjusting the position of the measurement magnetometer module to a position to be detected relative to the living being to be detected.
10. The method according to claim 9, wherein the position adjusting module comprises two horizontal guide rails (81) fixed on the field stabilizing coil module, a second horizontal guide rail (82) vertically arranged on the two horizontal guide rails (81) and capable of freely sliding, and a magnetometer fixing module (83) vertically arranged on the second horizontal guide rail (82); the magnetometer fixing module (83) comprises a vertical fixing rod (831) and a magnetometer fixing platform (832); the upper end of the vertical fixing rod (831) is connected with the second horizontal guide rail (82) and can freely slide along the second horizontal guide rail (82), and the lower end of the vertical fixing rod (831) is connected and fixed with a magnetometer fixing platform (832); the measuring magnetometer module is fixed to the magnetometer fixation platform (832).
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002232182A (en) * | 2001-02-02 | 2002-08-16 | Mti:Kk | Magnetic shielding room of internal active magnetically shielded system |
| JP2005003503A (en) * | 2003-06-11 | 2005-01-06 | Foresutekku:Kk | Magnetic-shielding method using induction coil |
| CN107984306A (en) * | 2018-01-28 | 2018-05-04 | 吉林大学 | A kind of magnetic field is distant to manipulate vortex flow orientation burnishing device and polishing method |
| CN109283476A (en) * | 2018-09-07 | 2019-01-29 | 中国科学院上海微***与信息技术研究所 | The low frequency intrinsic noise test macro and test method of Magnetic Sensor |
| CN210222235U (en) * | 2019-06-25 | 2020-03-31 | 无锡市计量测试院 | Magnetic sensor's test system |
| CN110958830A (en) * | 2019-12-27 | 2020-04-03 | 中国船舶重工集团有限公司第七一0研究所 | Combined type environmental interference magnetic field shielding system |
| WO2022041701A1 (en) * | 2020-08-24 | 2022-03-03 | 清华大学 | Atomic magnetometer and magnetic field imaging system |
| CN114264984A (en) * | 2021-11-22 | 2022-04-01 | 上海科技大学 | Weak magnetic field measuring method and system for zero-field optical pump atomic magnetometer |
-
2022
- 2022-10-18 CN CN202211274100.4A patent/CN115919318A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002232182A (en) * | 2001-02-02 | 2002-08-16 | Mti:Kk | Magnetic shielding room of internal active magnetically shielded system |
| JP2005003503A (en) * | 2003-06-11 | 2005-01-06 | Foresutekku:Kk | Magnetic-shielding method using induction coil |
| CN107984306A (en) * | 2018-01-28 | 2018-05-04 | 吉林大学 | A kind of magnetic field is distant to manipulate vortex flow orientation burnishing device and polishing method |
| CN109283476A (en) * | 2018-09-07 | 2019-01-29 | 中国科学院上海微***与信息技术研究所 | The low frequency intrinsic noise test macro and test method of Magnetic Sensor |
| CN210222235U (en) * | 2019-06-25 | 2020-03-31 | 无锡市计量测试院 | Magnetic sensor's test system |
| CN110958830A (en) * | 2019-12-27 | 2020-04-03 | 中国船舶重工集团有限公司第七一0研究所 | Combined type environmental interference magnetic field shielding system |
| WO2022041701A1 (en) * | 2020-08-24 | 2022-03-03 | 清华大学 | Atomic magnetometer and magnetic field imaging system |
| CN114264984A (en) * | 2021-11-22 | 2022-04-01 | 上海科技大学 | Weak magnetic field measuring method and system for zero-field optical pump atomic magnetometer |
Non-Patent Citations (2)
| Title |
|---|
| 李军;罗斌;郭弘;: "光存储与传统磁存储理论的比较研究", 量子光学学报, no. 01, 25 February 2008 (2008-02-25) * |
| 赵静;刘光达;安战锋;王君;: "提高高温超导磁力仪动态范围的补偿方法", 吉林大学学报(工学版), no. 05, 15 September 2011 (2011-09-15) * |
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