CN115902249A - Blood analyzer and diluent heating method - Google Patents

Abstract

The invention discloses a blood analyzer and a diluent heating method, wherein the blood analyzer comprises a shell, a heating device, a transfusion device and at least one liquid using device; the shell is used for accommodating the heating device, the infusion device and at least one liquid using device; the heating device is used for heating the diluent to a first target temperature; the infusion device is connected to the heating device and the administration device, respectively, for delivering the diluent from the heating device to the administration device, the infusion device absorbing heat from the internal environment of the housing and conducting heat to the diluent during infusion to raise the temperature of the diluent to a second target temperature prior to entering the administration device, the difference between the second target temperature and the internal temperature of the housing being less than a first threshold; the liquid using device is used for receiving the diluent to perform blood detection and obtaining a detection result. The blood analyzer has the advantages of low energy consumption, low production cost, small instrument size and high detection speed.

Description

Blood analyzer and diluent heating method

Technical Field

The invention relates to the technical field of blood analysis, in particular to a blood analyzer and a diluent heating method.

Background

The impedance detection device, hemoglobin (HGB) detection device, optical detection device etc. among the blood analysis appearance all need use the diluent, and moreover, the diluent temperature can influence the uniformity that detects the parameter. For example, during hemoglobin detection, the high temperature of the diluent results in a lower value of the HGB parameter; when the impedance channel is detected, the temperature of the diluent is high, which causes the numerical value of parameters such as MCV to be low.

In order to ensure the accuracy of the detection result, the detection result needs to be compensated based on the principle that the temperature affects the detection parameters under normal conditions. Because the diluent often needs to be stored at low temperature, the diluent has a large temperature difference with the environment, so that the temperature fluctuation is large in the diluent conveying process, the temperature of the diluent entering the detection device cannot be accurately determined, and the detection parameters cannot be accurately compensated.

The diluent is preheated in some blood analyzers with higher performance requirements, so that the temperature of the diluent is accurately controlled. That is, the diluent is heated to a fixed temperature and then transported to each detection device through a pipeline. To maintain the temperature of the diluent delivered to each test device constant, the diluent is typically heated to a higher target temperature, and the temperature fluctuations of the diluent are reduced by careful design of the material, length and orientation of the tubing during delivery of the diluent to the test device. Even so, because the diluent temperature in the pipeline is higher, from preheating the pond to impedance detection device, hemoglobin detection device and optical detection device's transportation process, the temperature of diluent still can fluctuate, moreover, because the hot temperature of diluent is higher, leads to preheating the volume of pond great, and the heating consumption is higher, is unfavorable for reducing blood analyzer's energy consumption level.

Disclosure of Invention

In view of the above problems in the prior art, the present invention provides a blood analyzer and a diluent heating method. The technical scheme adopted by the embodiment of the invention is as follows.

The invention provides a first aspect of a blood analyzer, which comprises a shell, a heating device, a transfusion device and at least one liquid using device;

the housing is used for accommodating the heating device, the infusion device and the at least one liquid using device;

the heating device is used for heating the diluent to a first target temperature, wherein the first target temperature is lower than the internal temperature of the shell;

the infusion device is connected with the heating device and the fluid using device respectively and used for conveying the diluent from the heating device to the fluid using device, the infusion device absorbs heat from the internal environment of the shell and conducts heat to the diluent during infusion so as to raise the temperature of the diluent to a second target temperature before the diluent enters the fluid using device, and the difference between the second target temperature and the internal temperature of the shell is smaller than a first threshold value;

the liquid using device is used for receiving the diluent to perform blood detection and obtaining a detection result.

In some embodiments, the first target temperature is a fixed temperature value that is lower than the internal temperature of the housing.

In some embodiments, the blood analyzer further comprises a control device for determining the first target temperature according to the internal temperature of the housing and controlling the heating device to heat the diluent according to the first target temperature.

In some embodiments, the control device is specifically configured to determine the first target temperature based on an internal temperature of the housing and a first warming range of the infusion device; wherein the first temperature rise range is a temperature range within which diluent can rise by absorbing heat from the infusion set prior to entering the administration set.

In some embodiments, the blood analyzer further comprises a first temperature sensor for detecting an internal temperature of the housing;

the control device is configured to acquire the internal temperature of the housing from the first temperature sensor.

In some embodiments, the control device is specifically configured to obtain an ambient temperature of the blood analyzer and determine the first target temperature using the ambient temperature as the internal temperature of the housing.

In some embodiments, the heating device includes a diluent reservoir for containing diluent and a heater, and the control device is configured to control the heater to heat the diluent in the diluent reservoir according to the first target temperature.

In some embodiments, the control device compensates the detection of the at least one fluid consuming device based on an internal temperature of the housing.

In some embodiments, the at least one fluid administration device is selected from the group consisting of a hemoglobin detection device, an impedance detection device, and an optical detection device, and when a plurality of fluid administration devices are present, the heating device is connected to each of the plurality of fluid administration devices via the infusion device disposed in parallel.

The invention provides a diluent heating method, which is applied to a blood analyzer, wherein the blood analyzer comprises a shell, and a heating device, a transfusion device and at least one liquid using device which are accommodated in the shell; the method for heating the diluent is characterized by comprising the following steps:

heating, by the heating device, a diluent to a first target temperature, wherein the first target temperature is lower than an internal temperature of the housing;

delivering diluent from the heating device to the administration device through the infusion device, absorbing heat from the internal environment of the housing and conducting heat to the diluent through the infusion device during infusion to raise the temperature of the diluent to a second target temperature prior to the diluent entering the administration device, the difference between the second target temperature and the internal temperature of the housing being less than a first threshold.

In the blood analyzer according to the embodiment of the present invention, the heating device heats the diluent stored at a low temperature to a first target temperature lower than the internal temperature of the housing, and the infusion device exchanges heat with the internal environment of the housing and the diluent, respectively, while the diluent is being fed to the fluid-using device through the infusion device, and the temperature of the diluent is raised to the internal temperature of the housing or approaches the internal temperature of the housing by using the heat of the internal environment of the housing. That is, instead of relying solely on a heating device to heat the diluent, the heat of the internal environment of the housing is also used to heat the diluent. So, heating device only need with the diluent heating to lower first target temperature can, not only can reduce the energy consumption, can reduce the power and volumetric configuration requirement to heating device moreover to adopt the less heating device of power and size just can satisfy the user demand, be of value to reduction in production cost and instrument size, simultaneously, can also shorten heating device to the heat time of diluent, be of value to the detection speed that improves blood analyzer.

Drawings

FIG. 1 is a schematic view of a blood analyzer according to an embodiment of the present invention;

FIG. 2 is a schematic diagram of a blood analyzer according to an embodiment of the present invention;

FIG. 3 is a schematic structural view of a control device of the blood analyzer according to the embodiment of the present invention;

FIG. 4 is a flow chart of a diluent heating method according to an embodiment of the present invention.

Detailed Description

Various aspects and features of the present invention are described herein with reference to the accompanying drawings.

It will be understood that various modifications may be made to the embodiments of the present application. Accordingly, the foregoing description should not be construed as limiting, but merely as exemplifications of embodiments. Other modifications within the scope and spirit of the invention will occur to those skilled in the art.

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and, together with a general description of the invention given above, and the detailed description of the embodiments given below, serve to explain the principles of the invention.

These and other characteristics of the invention will become apparent from the following description of a preferred form of embodiment, given as a non-limiting example, with reference to the accompanying drawings.

It is also to be understood that although the invention has been described with reference to specific examples, those skilled in the art are able to ascertain many other equivalents to the practice of the invention.

The above and other aspects, features and advantages of the present invention will become more apparent in view of the following detailed description when taken in conjunction with the accompanying drawings.

Specific embodiments of the present invention are described hereinafter with reference to the accompanying drawings; however, it is to be understood that the disclosed embodiments are merely exemplary of the invention, which can be embodied in various forms. Well-known and/or repeated functions and constructions are not described in detail to avoid obscuring the invention in unnecessary or unnecessary detail. Therefore, specific structural and functional details disclosed herein are not to be interpreted as limiting, but merely as a basis for the claims and as a representative basis for teaching one skilled in the art to variously employ the present invention in virtually any appropriately detailed structure.

The specification may use the phrases "in one embodiment," "in another embodiment," "in yet another embodiment," or "in other embodiments," which may each refer to one or more of the same or different embodiments in accordance with the invention.

Referring to fig. 1 and 2, an embodiment of the present invention provides a blood analyzer 100 that includes a housing 110, a heating device 120, an infusion device 130, and at least one administration set.

The housing 110 is adapted to house a heating device 120, an infusion set 130 and at least one administration set. For example, the housing 110 may have one or more internal chambers, and the heating device 120, the infusion set 130, and the at least one administration set may be disposed in the same internal chamber or may be distributed among different internal chambers.

The heating device 120 is used to heat the diluent to a first target temperature, wherein the first target temperature is lower than the internal temperature of the housing 110. Alternatively, the heating device 120 may have a heating chamber for containing the diluent, to which the diluent is delivered, heated to the first target temperature in the heating chamber. Alternatively, the heating device 120 may be connected to the container 200 for holding the diluent by, for example, tubing, and the container 200 may be an integral part of the blood analyzer or may be a separate device from the blood analyzer. The container 200 may be a cryogenic storage device, and the diluent is stored in the container 200 at a storage temperature that is less than the first target temperature.

The infusion device 130 is coupled to the heating device 120 and the administration device, respectively, for delivering the diluent from the heating device 120 to the administration device, the infusion device 130 absorbing heat from the internal environment of the housing 110 and conducting heat to the diluent during an infusion procedure to raise the temperature of the diluent to a second target temperature prior to entering the administration device, the difference between the second target temperature and the internal temperature of the housing 110 being less than the first threshold. Optionally, the infusion device 130 may include a power source for driving the diluent to flow in the infusion tube, and the infusion tube may be made of a material with a high thermal conductivity to increase the heat transferred to the diluent without changing the size of the infusion tube. The second target temperature may be lower than the internal temperature of the case 110 or may be the same as the internal temperature of the case 110.

The liquid using device is used for receiving the diluent to perform blood detection and obtaining a detection result.

Alternatively, the administration set may include a detection device, and the infusion set 130 may deliver the diluent to the detection device. The detection device utilizes the diluent to process the blood sample to be detected collected by the sampling device and detects the processed blood sample to be detected so as to obtain a detection result.

Alternatively, the administration set may comprise a sample preparation device, and the infusion set 130 may deliver the diluent to the sample preparation device. The sample preparation device may have at least one reaction cell and a reagent supply. The at least one reaction cell is used for receiving a blood sample to be tested sucked by the sampling device, and the reagent supply device is used for supplying a processing reagent to the at least one reaction cell, so that the blood sample to be tested sucked by the sampling device and the processing reagent supplied by the reagent supply device are mixed in the reaction cell to prepare a sample liquid to be tested. For example, the reagent supplying device may supply the diluting solution as a red blood cell reagent to the reaction cell, thereby preparing the blood sample to be tested into a sample solution to be tested. The detection device is configured to detect the sample liquid to be detected prepared by the sample preparation device so as to obtain a detection result.

In the blood analyzer according to the embodiment of the present invention, the heating device 120 heats the diluent stored at a low temperature to a first target temperature lower than the internal temperature of the housing 110, and while the diluent is being fed to the fluid-using device through the fluid feeding device 130, the fluid feeding device 130 exchanges heat with the internal environment of the housing 110 and the diluent, respectively, and the diluent is continuously heated by the heat of the internal environment of the housing 110, so that the diluent is heated to the internal temperature of the housing 110 or to a temperature close to the internal temperature of the housing 110. That is, the diluent is not heated solely by the heating device 120, but is heated by the heat of the internal environment of the housing 110. So, heating device 120 only need with the diluent heat to lower first target temperature can, not only can reduce the energy consumption, can reduce the power and the volumetric configuration requirement to heating device 120 moreover to adopt the less heating device 120 of power and size just can satisfy the user demand, be of value to reducing cost of generation and instrument size, simultaneously, can also shorten heating device 120 to the heat time of diluent, be of value to improving the detection speed of blood analysis appearance.

In some embodiments, the first target temperature may be a fixed temperature value that is lower than the internal temperature of the housing 110. For a thermostatic laboratory or a laboratory with relatively stable ambient temperature, the internal temperature of the body of the blood analyzer in such a laboratory is also relatively stable. At the time of factory shipment or at the time of calibration of the blood analyzer, the internal temperature of the blood analyzer used in such a laboratory may be determined, and then a fixed first target temperature may be set for the heating device 120 based on the internal temperature. Thus, the temperature of each liquid using device is kept stable, and the use difficulty of a user can be reduced.

In some embodiments, the blood analyzer may further include a control device 150. The control device 150 is configured to determine a first target temperature according to the internal temperature of the housing 110, and control the heating device 120 to heat the diluent according to the first target temperature. That is, the control device 150 may set a first target temperature lower than the internal temperature of the housing 110 according to the internal temperature of the housing 110 when the internal temperature of the housing 110 is determined, so that the temperature of the diluent with the first target temperature can be raised to the internal temperature of the housing 110 or close to the internal temperature of the housing 110 before the diluent is delivered to the administration set through the infusion device 130. With this control device 150, an automatic setting of the first target temperature can be achieved.

Alternatively, as shown in fig. 3, the control device 150 is configured as a controller including a processor and a storage medium storing a computer program. Specifically, control device 150 includes at least a processing component 151, a RAM152, a ROM153, a communication interface 154, a memory 156, and an I/O interface 155. Processing component 151, RAM152, ROM153, communication interface 154, memory 156, and I/O interface 155 communicate over a bus 157. The processing component may be a CPU, GPU or other chip with computing capabilities. The memory 156 stores various computer programs such as an operating system and an application program to be executed by the processor unit 151, and data necessary for executing the computer programs. In addition, data stored locally during the blood sample analysis may be stored in the memory 156, if desired. The I/O interface 155 is constituted by a serial interface such as USB, IEEE1394, or RS-232C, a parallel interface such as SCSI, IDE, or IEEE1284, and an analog signal interface composed of a D/a converter and an a/D converter. The I/O interface 155 is connected to an input device including a keyboard, a mouse, a touch panel, or other control buttons, and a user can directly input data to the control apparatus 150 using the input device. Further, a display device 140 having a display function, for example: liquid crystal screens, touch screens, LED display screens and the like. The control device 150 may output the processed data as image display data to a display device for display, for example: analytical data, instrument operating parameters, etc. Communication interface 154 is an interface that may be any communication protocol known today. The communication interface 154 communicates with the outside through a network. Control device 150 may communicate data with any device connected via the network via communication interface 154 in a communication protocol. The control device 150 may be a controller of the blood analyzer or a software module in the controller. Of course, the control device 150 may be a controller independent of the blood analyzer controller, and the invention is not limited thereto.

In particular implementations, the control device 150 may obtain the internal temperature of the housing 110 in a variety of ways. As in an alternative embodiment, the blood analyzer further includes a first temperature sensor for detecting the internal temperature of the housing 110; the control device 150 is configured to acquire the internal temperature of the housing 110 from the first temperature sensor. The first temperature sensor can be used for accurately detecting the internal temperature of the shell 110, so that the first target temperature can be accurately set, and the temperature of the diluent entering the liquid using device can be regulated, thereby being beneficial to improving the accuracy of the detection result.

Alternatively, a first temperature sensor may be disposed in the housing 110, and the control device 150 may be communicatively connected to the first temperature sensor, acquire the internal temperature of the housing 110 from the first temperature sensor, and determine the first target temperature of the heating device 120 according to the internal temperature of the housing 110. Alternatively, a first temperature sensor may be positioned near the infusion set 130 to reflect the detection of the actual temperature near the infusion set 130. Further, a plurality of first temperature sensors may be disposed at different positions in the housing 110, and the control device 150 may be respectively in communication connection with each of the first temperature sensors, and respectively obtain the detected temperature of each of the first temperature sensors, and may determine the internal temperature of the body according to a plurality of detected temperatures.

Alternatively, the control device 150 may acquire the internal temperature of the housing 110 from the first temperature sensor in real time, and adjust the first target temperature of the heating device 120 in real time. Therefore, the temperature of the diluent and the internal temperature of the shell 110 can keep good dynamic consistency, and the detection result can be accurately compensated based on the internal temperature of the shell 110 in the subsequent link, which is beneficial to improving the accuracy of the detection result.

Alternatively, the control device 150 may also obtain the internal temperature of the casing 110 from the first temperature sensor in real time, determine whether the internal temperature of the casing 110 fluctuates within a preset range, and adjust the first target temperature based on the current internal temperature of the casing 110 when it is determined that the internal temperature of the casing 110 exceeds the preset range. Of course, the control device 150 may also periodically acquire the internal temperature of the housing 110 from the first temperature sensor. For example, the control device 150 may obtain the internal temperature of the housing 110 each time the blood monitor is activated, or the control device 150 may obtain the internal temperature of the housing 110 every 24 hours, week, or other time interval and adjust the first target temperature of the heating device 120.

In another alternative embodiment, the user may also manually input the internal temperature of the housing 110. For example, a prompt message may be displayed by its display unit each time the blood analyzer is activated to prompt the user to input the internal temperature of the housing 110. The user may input the internal temperature of the housing 110 to the blood analyzer, for example, via an input device.

In yet another alternative embodiment, the control device 150 may be configured to obtain an ambient temperature of the blood analyzer and determine the first target temperature using the ambient temperature as the internal temperature of the housing 110. The ambient temperature of the blood analyzer is long enough to reflect the internal temperature of the housing 110, and therefore, the control device 150 can also determine the first target temperature of the heating device 120 based on the ambient temperature. Alternatively, a temperature sensor for detecting the ambient temperature may be disposed outside the housing 110, and the control device 150 may be communicatively connected to the temperature sensor to obtain the ambient temperature from the temperature sensor. Alternatively, the control device 150 may obtain the ambient temperature of the environment where the blood analyzer is located through a network. For example, the control device 150 may be communicatively connected to a central control system of a laboratory to obtain an ambient temperature of the laboratory from the central control system.

In some embodiments, the control device 150 is specifically configured to determine a first target temperature based on the internal temperature of the housing 110 and a first temperature rise range of the infusion device 130; wherein the first temperature rise range is a temperature range within which the diluent can rise by absorbing heat from the infusion set 130 prior to entering the administration set. For example, the control device 150 may use the internal temperature of the casing 110 minus the first temperature rise range, and take the obtained difference as the first target temperature. In this way, it is ensured that the diluent is heated to the internal temperature of the housing 110 or close to the internal temperature of the housing 110 before entering the liquid using device. The first temperature rise range is influenced by design parameters such as the material, the length, the sectional area, the transfusion speed and the like of the transfusion pipeline. When the length of the infusion tube is longer, the first temperature rise range is larger, and the first target temperature can be set lower to reduce the power consumption of the heating device 120. Optionally, before the blood analyzer leaves the factory, a first temperature-increasing range may be preset, or the control device 150 may determine the first temperature-increasing range according to design parameters such as the material and/or the length of the infusion tube.

In some embodiments, as shown in fig. 2, the blood analyzer may further include a second temperature sensor 160, the second temperature sensor 160 being configured to detect a temperature of the diluent entering the administration set, and the control device 150 being configured to adjust the first target temperature based on the detected temperature of the second temperature sensor 160 such that the temperature of the diluent entering the administration set approaches the interior temperature of the housing 110 indefinitely.

In some embodiments, the heating device 120 may include a diluent reservoir for containing the diluent, that is, the diluent reservoir defines a heating cavity for containing the diluent, and a heater for heating the diluent in the diluent reservoir, and the control device 150 is configured to control the heater to heat the diluent in the diluent reservoir according to the first target temperature. Optionally, the diluent reservoir may be connected to the container 200 so that the diluent in the container 200 can be replenished to the diluent reservoir at a proper time. Of course, the heating cavity of the heating device 120 may also be directly defined by the heater. For example, a fluid passage may be provided in the heater, and the heater heats the diluent flowing in the fluid passage.

In some embodiments, the at least one fluid administration device is selected from the group consisting of a hemoglobin detection device 143, an impedance detection device 142, and an optical detection device 141. When there are a plurality of liquid using devices, the heating device 120 is connected to each of the plurality of liquid using devices via the infusion device 130 arranged in parallel. The optical detection device 141 is used for detecting leukocyte parameters or erythrocyte parameters of a sample to be detected, the sheath flow impedance detection device 142 is used for detecting erythrocyte and/or platelet parameters of the sample to be detected, and the Hemoglobin (HGB) detection device 143 is used for detecting hemoglobin parameters of the sample to be detected.

Alternatively, the optical detection device 141 may include a first reaction cell, a first sample transport portion, an optical flow cell, a light source, and a fluorescence detector.

The first reaction cell is used for receiving a part of a blood sample to be tested collected by the sampling device, so that the part of the blood sample to be tested is mixed and incubated with a reagent such as a hemolytic agent (for dissolving red blood cells in the blood sample) or a diluent and a staining agent (for staining cells in the blood sample) in the first reaction cell to form a first sample liquid to be tested.

The first sample conveying part is used for conveying the first sample liquid to be measured to the optical flow chamber. The first sample transport section may include a sample preparation line, a valve, a first syringe for drawing the sample liquid to be measured in the first reaction cell into the sample preparation line by a valve control technique, and a second syringe for pushing the first sample liquid to be measured in the sample preparation line into the optical flow cell by a valve control technique.

The conveying device is used for conveying the heated diluent in the diluent pool to the optical flow chamber as a sheath liquid, so that the diluent or the sheath liquid is mixed with the first sample liquid to be detected, for example, the mixture is mixed at an inlet of the optical flow chamber and then enters a detection area of the optical flow chamber. Specifically, the diluent pool is in fluid communication with the optical flow cell via a delivery conduit and a valve, and the power source of the delivery device draws or pushes the diluent in the diluent pool into the optical flow cell via the delivery conduit via a valve control technique.

The light source is used for irradiating the first sample liquid to be detected passing through the detection area of the optical flow chamber. The fluorescence detector is used for detecting a fluorescence signal generated after the particles in the first sample solution to be detected are irradiated by light in the detection area.

In addition, the outlet of the optical flow cell is also in communication with a waste reservoir through a valve to drain the detected sample fluid. The first reaction cell is also communicated with the waste liquid cell through a valve so as to discharge the residual sample liquid in the first reaction cell.

In addition, the optical detection device 141 further includes a scattered light detector for detecting a scattered light signal, such as a forward scattered light signal, generated after the particles in the first sample liquid to be detected are irradiated with light in the detection region.

Alternatively, the sheath flow impedance detection device 142 includes a second reaction cell, a second sample delivery unit, a sheath flow impedance flow chamber having a detection hole with an electrode, and an impedance detection circuit electrically connected to the electrode. The second reaction chamber is used for receiving a part of the blood sample to be tested collected by the sampling device, so that the part of the blood sample to be tested is mixed with a reagent, such as a diluent, and incubated in the second reaction chamber to form a second sample liquid to be tested. The second sample transport unit is configured to transport the second sample liquid to be measured to the sheath flow impedance flow chamber. The conveying device is used for conveying the heated diluent in the diluent pool as sheath fluid to the sheath flow impedance flow chamber so that the diluent and the second sample fluid to be detected are mixed and then enter the detection hole of the sheath flow impedance flow chamber. The impedance detection circuit is used for detecting an impedance signal generated when the particles in the second sample liquid to be detected pass through the detection hole.

In particular, the power source for the second sample transport unit to transport the second sample liquid to be tested to the sheath flow resistance flow cell may be the syringe described above. Of course, the second sample transport portion may include a power source independent of the syringe.

Alternatively, the hemoglobin detecting device 143 includes a third reaction cell and a colorimetry detecting portion. The third reaction tank is used for receiving a part of the sample to be detected collected by the sampling device. The conveying device is used for conveying the heated diluent in the diluent pool to the third reaction pool so that the diluent is mixed with the sample liquid to be detected in the third reaction pool to form a third sample liquid to be detected. The colorimetric detection part is used for detecting the hemoglobin parameter of the third sample solution to be detected. Preferably, the third reaction cell also serves as the second reaction cell, that is, the sheath flow impedance detecting means 142 and the hemoglobin detecting means 143 may share one reaction cell.

In some embodiments, the control device 150 compensates the detection of the at least one fluid consuming device based on the internal temperature of the housing 110. The temperature in the laboratory where the blood analyzer is located is typically more stable, the internal temperature of the housing 110 is typically more stable, and the heating device 120 and the infusion set 130 are heated to heat the diluent to a second target temperature, the difference between the second target temperature and the internal temperature of the housing 110 being less than the first threshold value. The first threshold is a maximum allowable temperature difference between the second target temperature and the internal temperature of the casing 110, and the maximum allowable temperature difference causes an error that is a maximum allowable error of the detection result. That is, the error caused by the temperature difference between the second target temperature and the internal temperature of the casing 110 is within the allowable error, and on the basis that the control device 150 compensates the detection result of the detection device based on the internal temperature of the casing 110, it is possible to obtain a detection result having an error within the allowable range.

Optionally, the control means 150 non-linearly compensates the fluorescence signal depending on the internal temperature of the housing 110 according to the present invention. In other embodiments, the fluorescence signal may also be linearly compensated simply based on the internal temperature of the housing 110 according to the present invention.

Optionally, the control device 150 is further configured to compensate the impedance signal measured by the sheath flow impedance detection device 142 according to the internal temperature of the housing 110 according to the present invention. Further, the control device 150 obtains the average red blood cell volume of the sample to be measured from the impedance signal and corrects or compensates the average red blood cell volume, for example by-0.3% per degree celsius, based on the internal temperature of the housing 110 according to the invention.

Optionally, the control device 150 is further configured to correct or compensate the hemoglobin parameter measurement result of the hemoglobin measurement device 143 according to the internal temperature of the housing 110 according to the present invention, for example, by-0.8% per degree celsius.

The embodiment of the invention also provides a diluent heating method which is applied to a blood analyzer, wherein the blood analyzer comprises a shell, and a heating device, a transfusion device and at least one liquid using device which are contained in the shell.

Referring to fig. 4, a method for heating a diluent according to an embodiment of the present invention may specifically include the following steps:

s201, heating the diluent to a first target temperature through a heating device, wherein the first target temperature is lower than the internal temperature of the shell;

and S202, conveying the diluent from the heating device to the liquid using device through the liquid conveying device, absorbing heat from the internal environment of the shell through the liquid conveying device in the liquid conveying process, and conducting heat to the diluent so as to raise the temperature of the diluent to a second target temperature before the diluent enters the liquid using device, wherein the difference value between the second target temperature and the internal temperature of the shell is smaller than a first threshold value.

In some embodiments, the first target temperature is a fixed temperature value that is lower than the internal temperature of the housing.

In some embodiments, the hematology analyzer further includes a control device; the method further comprises the following steps:

determining, by a control device, a first target temperature from an internal temperature of the housing;

and controlling the heating device to heat the diluent by the control device according to the first target temperature.

In some embodiments, determining, by the control device, the first target temperature from the internal temperature of the housing comprises:

determining a first target temperature by the control device according to the internal temperature of the housing and a first temperature rise range of the infusion device; wherein the first temperature rise range is a temperature range within which the diluent can rise by absorbing heat from the infusion set prior to entering the administration set.

In some embodiments, the blood analyzer further comprises a first temperature sensor; the method further comprises the following steps:

detecting an internal temperature of the case through a first temperature sensor;

the internal temperature of the housing is acquired from the first temperature sensor by the control device.

In some embodiments, determining, by the control device, the first target temperature from the internal temperature of the housing comprises:

the ambient temperature of the blood analyzer is acquired by the control device, and the first target temperature is determined using the ambient temperature as the internal temperature of the housing.

In some embodiments, the heating device comprises a diluent reservoir for holding diluent and a heater; controlling the heating device to heat the diluent by the control device according to the first target temperature, comprising:

and controlling the heater to heat the diluent in the diluent pool by the control device according to the first target temperature.

The above embodiments are only exemplary embodiments of the present invention, and are not intended to limit the present invention, and the scope of the present invention is defined by the claims. Various modifications and equivalents may be made by those skilled in the art within the spirit and scope of the present invention, and such modifications and equivalents should also be considered as falling within the scope of the present invention.

Claims (10)

1. A blood analyzer is characterized by comprising a shell, a heating device, a transfusion device and at least one liquid using device;

the housing is used for accommodating the heating device, the infusion device and the at least one liquid using device;

the heating device is used for heating the diluent to a first target temperature, wherein the first target temperature is lower than the internal temperature of the shell;

the infusion device is connected with the heating device and the fluid using device respectively and used for conveying the diluent from the heating device to the fluid using device, the infusion device absorbs heat from the internal environment of the shell and conducts heat to the diluent during infusion so as to raise the temperature of the diluent to a second target temperature before the diluent enters the fluid using device, and the difference between the second target temperature and the internal temperature of the shell is smaller than a first threshold value;

the liquid using device is used for receiving the diluent to perform blood detection and obtaining a detection result.

2. The blood analyzer of claim 1, wherein the first target temperature is a fixed temperature value that is lower than an internal temperature of the housing.

3. The blood analyzer of claim 1, further comprising a control device for determining the first target temperature based on an internal temperature of the housing and controlling the heating device to heat the diluent based on the first target temperature.

4. The hematology analyzer of claim 3, wherein the control device is specifically configured to determine the first target temperature based on an internal temperature of the housing and a first temperature rise range of the infusion device; wherein the first temperature rise range is a temperature range within which diluent can rise by absorbing heat from the infusion set prior to entering the administration set.

5. The blood analyzer of claim 3 or 4, further comprising a first temperature sensor for detecting an internal temperature of the housing;

the control device is configured to acquire the internal temperature of the housing from the first temperature sensor.

6. A blood analyser according to claim 3 or 4 wherein the control means is specifically configured to take an ambient temperature of the blood analyser and determine the first target temperature using the ambient temperature as the internal temperature of the housing.

7. A blood analyser according to claim 3 or 4 wherein the heating means comprises a diluent reservoir for containing diluent and a heater, and the control means is configured to control the heater to heat diluent in the diluent reservoir in dependence on the first target temperature.

8. A blood analyser according to claim 3 or 4 wherein the control means compensates the detection of the at least one fluid consuming device in dependence on the internal temperature of the housing.

9. The blood analyzer of claim 1, wherein the at least one fluid consuming device is selected from the group consisting of a hemoglobin detecting device, an impedance detecting device, and an optical detecting device, and when a plurality of fluid consuming devices are present, the heating device is connected to each of the plurality of fluid consuming devices through the infusion set arranged in parallel.

10. A diluent heating method is applied to a blood analyzer, the blood analyzer comprises a shell, and a heating device, a transfusion device and at least one liquid using device which are contained in the shell; the method for heating the diluent is characterized by comprising the following steps:

heating, by the heating device, the diluent to a first target temperature, wherein the first target temperature is lower than an internal temperature of the housing;

delivering diluent from the heating device to the administration device through the infusion device, absorbing heat from the internal environment of the housing and conducting heat to the diluent through the infusion device during infusion to raise the temperature of the diluent to a second target temperature prior to the diluent entering the administration device, the difference between the second target temperature and the internal temperature of the housing being less than a first threshold.

Images