CN115888398A - Tangential flow membrane group, tangential flow membrane component, preparation method and application thereof - Google Patents
Tangential flow membrane group, tangential flow membrane component, preparation method and application thereof Download PDFInfo
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- CN115888398A CN115888398A CN202111117266.0A CN202111117266A CN115888398A CN 115888398 A CN115888398 A CN 115888398A CN 202111117266 A CN202111117266 A CN 202111117266A CN 115888398 A CN115888398 A CN 115888398A
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Abstract
The invention relates to the field of material science, and discloses a tangential flow membrane group, a tangential flow membrane component, a preparation method and an application thereof. The tangential flow membrane set provided by the invention comprises an ultrafiltration membrane layer I, a water inlet grid layer, an ultrafiltration membrane layer II and a water production grid layer which are sequentially stacked, wherein the water inlet grid layer comprises water inlet flow passage holes, the water production grid layer comprises water production flow passage holes, the ultrafiltration membrane layer I and the ultrafiltration membrane layer II both comprise water inlet flow passage holes and water production flow passage holes, and the peripheries of the layers and the peripheries of the water inlet flow passage holes and/or the water production flow passage holes are sealed and bonded by hot melt adhesive. The tangential flow membrane module provided by the invention is formed by sequentially stacking and bonding 1-30 membrane sheets. The membrane component has small volume, high filling density and high processing precision, and can be applied to the fields of biology, pharmacy and the like.
Description
Technical Field
The invention relates to the field of material science, in particular to a tangential flow membrane group, a tangential flow membrane component, a preparation method and application thereof.
Background
Tangential Flow (Tangential Flow Filtration or Cross Flow) refers to a form of Filtration in which the Flow direction of liquid is perpendicular to the Filtration direction, and is widely used in ultrafiltration and partial microfiltration processes. For traditional vertical filtration, the filtration form that liquid flow direction and filtration direction are unanimous promptly, the tangential flow filtration is handled and can be filtered great large-scale feed liquid, this is because when adopting the tangential flow to filter, the feed liquid flows and produces the shearing force on the filter medium surface, has reduced the pile up of filter cake layer or gel layer to filter speed has been ensured, and during vertical filtration, feed liquid and filter medium contact, the velocity of flow will reduce rapidly, especially under the less or higher condition of solid content in the feed liquid of filter medium aperture, this kind of defect of vertical filtration is more obvious.
At present, the tangential flow filtration system is mainly applied to the aspects of concentration, purification, dialysis, replacement of buffer solution or culture solution, heat removal and the like of biological products, medicines and the like. Typical tangential flow filtration systems include pumps, membrane packages, clamps, reservoirs, connecting tubing, valves, pressure gauges, etc., wherein the membrane package is an ultrafiltration or microfiltration membrane module that is the core of the tangential flow filtration system. The tangential flow filtration membrane package has high working pressure, needs repeated sterilization, and requires small amount of residual liquid, so that the conventional ultrafiltration or microfiltration membrane module cannot meet the requirements of tangential flow filtration.
Common membrane modules for tangential flow filtration include both of a wound membrane module and a plate-and-frame type, wherein the wound membrane module refers to a tangential flow membrane module prepared by spirally winding a flat membrane on a central tube, and for example, a spirally wound filtration module disclosed in CN110756051A is a wound membrane module. However, the ultrafiltration membrane used in the wound membrane module has a large area, a large residual volume, and a high use cost. The plate-and-frame membrane component is characterized in that two flat membrane sheets are pasted or welded on two sides of the supporting plate, water is produced by utilizing negative pressure, but the plate-and-frame membrane component has small filling density when the membrane is stacked, and when liquid glue is adopted for pasting, the glue amount is small, so that the precision control is difficult, bubbles are easily generated, and the quality of the membrane component is influenced.
Disclosure of Invention
The invention aims to solve the problems that a flat plate type tangential flow membrane component in the prior art is difficult to prepare, a traditional plate-frame type flat plate membrane can only be welded or pasted with two layers of membranes on two sides of a support plate, the loading density is low, and the quality of the membrane component is difficult to control, and provides a tangential flow membrane group, a tangential flow membrane component and a preparation method thereof. The tangential flow membrane set provided by the invention adopts the hot melt adhesive to bond the multilayer ultrafiltration membrane with the water production grid, the water inlet grid and the like, so that the filling density of the membrane is improved.
In order to achieve the above object, the present invention provides a tangential flow membrane module, which includes an ultrafiltration membrane layer I, a water inlet grid layer, an ultrafiltration membrane layer II, and a water production grid layer, which are stacked in sequence, wherein the water inlet grid layer includes water inlet flow channel holes, the water production grid layer includes water production flow channel holes, the ultrafiltration membrane layer I and the ultrafiltration membrane layer II both include water inlet flow channel holes and water production flow channel holes, and the peripheries of the respective layers and the peripheries of the water inlet flow channel holes and/or the water production flow channel holes are bonded by edge sealing with hot melt adhesive.
The invention provides a tangential flow membrane module, which comprises 1-30 tangential flow membrane groups which are sequentially stacked, bonded and sealed, wherein the tangential flow membrane groups are the tangential flow membrane groups, preferably, in the tangential flow membrane module, water production flow passage holes are aligned with each other, and water inlet flow passage holes are aligned with each other between two adjacent membrane groups.
In a third aspect, the present invention provides a method of making a tangential flow membrane module, the method comprising:
(1) Preparing a tangential flow membrane group: cutting an ultrafiltration membrane, a water inlet grid, a water production grid and a hot melt adhesive film, and stacking the ultrafiltration membrane, the water inlet grid, the ultrafiltration membrane and the hot melt adhesive film in sequence according to an ultrafiltration membrane layer I, a water inlet grid layer, an ultrafiltration membrane layer II and a water production grid layer, wherein the water inlet grid layer comprises water inlet flow passage holes, the water production grid layer comprises water production flow passage holes, the ultrafiltration membrane layer I and the ultrafiltration membrane layer II both comprise water inlet flow passage holes and water production flow passage holes, and the cut hot melt adhesive film is placed between two adjacent layers for bonding the periphery of each layer and the periphery of the water inlet flow passage holes and/or the periphery of the water production flow passage holes in a sealing manner;
(2) Preparing a tangential flow membrane module: sequentially stacking and bonding the tangential flow membrane groups obtained in the step (1) by 1-30 in sequence, and bonding and sealing the periphery of the stacked membrane groups by adopting a sealant to form edge sealing.
A fourth aspect of the invention provides a tangential flow membrane module obtained by the method as described above.
A fifth aspect of the invention provides the use of a tangential flow membrane module or a set of tangential flow membranes as described above for the preparation of a pharmaceutical and/or biological product.
According to the technical scheme, the multilayer ultrafiltration membrane sheet, the water inlet grid, the water production grid and the like are bonded together by using the hot melt adhesive, so that the filling density of the membrane can be improved. And the directions of the water production flow passage hole and the water inlet flow passage hole are set, so that the water inlet passage and the water production passage are effectively isolated, and the membrane assembly is convenient to package. In addition, the water production flow channel hole and the water inlet flow channel hole in the membrane group can be opened before edge sealing and bonding, so that positioning of each layer in the membrane group is facilitated, and the processing precision of the assembly is improved. In addition, the invention also solves the problem that the liquid sealant is easy to generate bubbles in the gluing process due to small using amount, ensures the integrity of the membrane component and is more beneficial to large-scale production and operation.
Drawings
FIG. 1 is an SEM image of a water inlet grid/water generating grid used for preparing a membrane set A1 in example 1 of the present invention;
fig. 2 is a schematic structural diagram of two adjacent membrane assemblies in the membrane assembly provided by the present invention (only showing the bonding condition of each layer at the water inlet flow channel, and the sealing condition of the hot melt adhesive to the water production flow channel hole of the water inlet grid mesh layer and the water inlet flow channel hole of the water production grid mesh layer).
Description of the reference numerals
The device comprises a water inlet flow passage 1, a water production flow passage 2, a hot melt adhesive 3, a water production grid layer 4, an ultrafiltration membrane support layer 5, an ultrafiltration membrane separation layer 6 and a water inlet grid layer 7.
Detailed Description
The endpoints of the ranges and any values disclosed herein are not limited to the precise range or value, and such ranges or values should be understood to encompass values close to those ranges or values. For ranges of values, between the endpoints of each of the ranges and the individual points, and between the individual points may be combined with each other to give one or more new ranges of values, and these ranges of values should be considered as specifically disclosed herein.
The traditional plate-and-frame flat membrane component generally adopts a structure that membranes are pasted or welded on two sides of a supporting plate, the structure not only enables the membrane component to have small filling density and relatively large volume, but also ensures the quality of the membrane component difficultly by adopting a pasting or welding process, and the traditional plate-and-frame flat membrane component can only be generally applied to the technical process with lower requirements on a filtering system, such as sewage treatment and the like.
The inventor of the invention skillfully discovers in the research process that a tangential flow membrane group with high processing precision and convenient encapsulation can be obtained by cutting the grid and the flat ultrafiltration membrane according to a certain shape, then stacking according to a specific sequence, sticking and sealing the grid and the flat ultrafiltration membrane by adopting a hot melt adhesive film cut according to the shapes of the cut grid and the flat ultrafiltration membrane and the area needing to be sealed, and arranging special water inlet and water production channels on the grid and the flat ultrafiltration membrane. And then, the tangential flow membrane components with high filling density, good integrity and good quality can be obtained by sticking and sealing the plurality of tangential flow membrane groups again. The membrane component has higher filtration precision, and the volume of the component and the residual volume of liquid during use are relatively smaller, so that the membrane component can meet the ultrafiltration/microfiltration requirements in the fields of biology, pharmacy and the like.
The invention provides a tangential flow membrane group, which comprises an ultrafiltration membrane layer I, a water inlet grid layer, an ultrafiltration membrane layer II and a water production grid layer which are sequentially stacked, wherein the water inlet grid layer comprises water inlet flow passage holes, the water production grid layer comprises water production flow passage holes, the ultrafiltration membrane layer I and the ultrafiltration membrane layer II respectively comprise water inlet flow passage holes and water production flow passage holes, and the peripheries of the layers and the peripheries of the water inlet flow passage holes and/or the water production flow passage holes are sealed and bonded by hot melt adhesives.
In the above description, the phrase "the water inlet mesh layer includes water inlet flow passage holes and the water production mesh layer includes water production flow passage holes" means that the water inlet flow passage holes of the water inlet mesh layer are kept open so that liquid can enter the membrane group from the water inlet flow passage holes of the water inlet mesh layer, and the water production flow passage holes of the water production flow passage mesh layer are kept open so that liquid can flow out of the membrane group from the water production flow passage holes of the water production mesh layer. In order to facilitate production, the water inlet grid mesh layer and the water production grid mesh layer can be provided with water inlet flow channel holes and water production flow channel holes during cutting, and the water production flow channel holes of the water inlet grid mesh layer and the water inlet flow channel holes of the water production grid mesh layer can be sealed only in the process of bonding and edge sealing. For example, in the invention, hot melt adhesive is adopted to bond and close each layer, so when the periphery of the water production flow passage hole of the water inlet grid layer is bonded, the melted hot melt adhesive can enter the mesh hole of the water inlet grid layer, and the bonding and the closing of the water production flow passage hole of the water inlet grid layer are completed simultaneously after the cooling and the solidification.
Preferably, hot melt adhesive edge sealing and bonding are not performed around the water inlet flow channel holes among the ultrafiltration membrane layer I, the water inlet grid mesh layer and the ultrafiltration membrane layer II.
Preferably, hot melt adhesive edge sealing and bonding are not carried out around the water production flow passage hole between the ultrafiltration membrane layer II and the water production grid mesh layer.
The shape of the tangential flow membrane group provided by the invention can be adjusted and set according to actual needs, the adaptability of the tangential flow membrane group to the existing tangential flow filtration system is improved in consideration of the convenience of preparation and use, and each layer of membranes and grids in the membrane group can be cut into rectangles.
In the tangential flow membrane module provided by the invention, the distribution of the water inlet flow passage holes and the water production flow passage holes on the ultrafiltration membrane layers (I and II) is not particularly limited as long as the water inlet flow passage holes and the water production flow passage holes on the same ultrafiltration membrane layer are not overlapped. In order to better isolate the water inlet channel and the water production channel and improve the filtering effect of the membrane group, according to the preferred embodiment of the invention, the water inlet channel hole and the water production channel hole on the ultrafiltration membrane layers (I and II) are respectively positioned at two ends of the membrane (for example, at two ends along the length direction of the rectangle).
According to a preferred embodiment of the present invention, wherein the water inlet flow passage holes of the water inlet grid layer and the water production flow passage holes of the water production grid layer are arranged (spaced) across each other (in the same tangential flow membrane stack). For example, at both ends in the length direction of the rectangle.
Preferably, the water inlet runner holes on the water inlet grid layer, the ultrafiltration membrane layer I and the ultrafiltration membrane layer II are respectively positioned at the same position (in the same tangential flow membrane group) and have the same size, and the water inlet runner holes between the upper layer and the lower layer are aligned with each other. Thereby, the water inlet flow channel is formed in the membrane group.
Preferably, the water production flow passage holes on the water production grid layer, the ultrafiltration membrane layer I and the ultrafiltration membrane layer II are respectively positioned at the same position (in the same tangential flow membrane group) and have the same size, and the water production flow passage holes between the upper layer and the lower layer are aligned with each other. Thereby, a water production flow channel is formed in the membrane group.
In the membrane group provided by the invention, the specific sizes of the water inlet flow passage hole and the water production flow passage hole are not particularly limited, and can be adjusted according to actual conditions (such as the characteristics of filtrate, the requirement on the filtering effect and the like). For the purpose of balancing the flow rate and pressure of the feed liquid, the concentrate and the permeate, it is preferable that the size of the inlet flow channel hole is larger than that of the product flow channel hole. More preferably, the size of the inlet flow channel hole is 1.2 to 1.5 times that of the outlet flow channel hole. The dimensions refer to the diameter of the (single) inlet flow channel hole/product flow channel hole (i.e. the diameter of the inlet flow channel/product flow channel in the membrane stack).
In the membrane group provided by the invention, a plurality of water inlet flow passage holes and/or water production flow passage holes can be arranged on each layer (namely, the membrane group can contain a plurality of water inlet flow passages and/or water production flow passages). Preferably, the number of the water inlet flow passage holes of the ultrafiltration membrane layer I is the same as that of the water production flow passage holes. Preferably 2-10, respectively. According to the position and size relationship of the water inlet flow channel holes and the water production flow channel holes among the layers, a person skilled in the art can understand that the number of the water inlet flow channel holes of the ultrafiltration membrane layer I is the same as that of the water production flow channel holes. Preferably 2-10, respectively. That is, in the tangential flow membrane set provided by the invention, the number of the water inlet flow channels is the same as that of the water production flow channels, and preferably 2-10 water inlet flow channels and water production flow channels are respectively provided.
Preferably, the total area of the inlet flow passage apertures does not exceed 5% of the area of the membrane. Preferably not more than 2% of the area of the membrane.
In the tangential flow membrane group provided by the invention, the water inlet grid layer/the water production grid layer has the function of generating a gap between the ultrafiltration membranes so that liquid to be treated can enter the gap. In the present invention, there is no particular limitation on the selection of the material of the water inlet mesh layer/water production mesh layer, as long as the tangential flow membrane sheet set can perform the above-mentioned function.
According to a preferred embodiment of the present invention, the water inlet mesh layer is made of polypropylene and/or polyethylene terephthalate. In order to control the material dissolving-out and safety, the water inlet grid layer is preferably made of medical-grade polypropylene and/or medical-grade polyethylene terephthalate.
According to a preferred embodiment of the present invention, the water grid producing layer is made of polypropylene and/or polyethylene terephthalate. In order to control the material dissolution and safety, the water producing mesh layer is preferably medical grade polypropylene and/or medical grade polyethylene terephthalate.
In the tangential flow diaphragm group provided by the invention, the water production grid layer and the water inlet grid layer can be made of the same material or different materials. In order to simplify the preparation process, the water producing grid layer and the water inlet grid layer are preferably made of the same material.
In order to provide sufficient support for the membrane and at the same time provide sufficient flow channels for the feed liquid and reduce the liquid flow resistance, the water inlet grid layer preferably adopts a grid with a mesh number of 20-80 meshes. More preferably 30-80 mesh.
More preferably, the thickness of the water inlet mesh layer is 120 to 150 μm.
In order to provide sufficient support for the membrane and at the same time provide sufficient flow channels for the permeate and reduce the flow resistance of the liquid, the water producing grid layer preferably has a mesh size of 60-100 mesh.
More preferably, the thickness of the layer of water grid mesh is 140-200 μm.
In the tangential flow diaphragm group provided by the invention, the mesh number of the grids adopted by the water production grid layer is larger than that of the grids adopted by the water inlet grid layer (namely the aperture of the water production grid layer is smaller than that of the water inlet grid layer). Preferably, the mesh number of the grids adopted by the water producing grid layer is 1.3-5 times that of the grids adopted by the water inlet grid layer.
In the tangential flow membrane set provided by the invention, the ultrafiltration membrane layers (I and II) can be prepared by adopting the existing (flat plate) ultrafiltration membrane meeting the pore size requirement in the field. The pore size requirement is determined by the nature of the solution being treated and the purpose of the filtration. In order to make the membrane sheet group easier to cut and assemble, according to the preferred embodiment of the invention, the ultrafiltration membranes used in the ultrafiltration membrane layer I and the ultrafiltration membrane layer II comprise an ultrafiltration membrane separation layer and an ultrafiltration membrane support layer. The ultrafiltration membrane separation layer is a membrane material layer which plays a role in filtration and separation, and the ultrafiltration membrane support layer is used for providing a supporting force for the ultrafiltration membrane separation layer so as to keep the ultrafiltration membrane separation layer flat.
In the invention, the ultrafiltration membrane layers (I and II) can be made of (flat) organic ultrafiltration membranes directly provided with supporting layers. The ultrafiltration membrane material with the support layer compounded by adopting a coating mode and the like before the membrane group is prepared can also be used. Alternatively, the ultrafiltration membrane layer may be formed by stacking (and bonding) the membrane sheets as the support layer of the ultrafiltration membrane and the membrane sheets as the separation layer of the ultrafiltration membrane, which are independent, in this order when the membrane group is prepared.
Preferably, the thickness ratio of the ultrafiltration membrane separation layer to the ultrafiltration membrane support layer is 1:1-3.
Preferably, the ultrafiltration membrane support layer material is selected from at least one of polyethylene terephthalate, polypropylene and polyethylene. In consideration of safety and other aspects, the material of the ultrafiltration membrane support layer is preferably at least one of medical polyethylene terephthalate, medical polypropylene and medical polyethylene.
More preferably, the ultrafiltration membrane support layer material has a weight average molecular weight of 2 × 10 4 -6×10 5 。
Preferably, the ultrafiltration membrane separation layer material is selected from at least one of polyvinylidene fluoride, polyethersulfone and regenerated cellulose. In consideration of safety and other aspects, the material of the ultrafiltration membrane separation layer is preferably at least one of medical polyvinylidene fluoride, medical polyethersulfone and medical regenerated cellulose.
The thickness of the ultrafiltration membrane layers (I and II) in the tangential flow membrane module provided by the present invention is not particularly limited. In order to enhance the filtering effect, according to a preferred embodiment of the present invention, wherein the thickness of the ultrafiltration membrane layer is 200 to 300 μm. That is, for one ultrafiltration membrane layer, the total thickness of the ultrafiltration membrane separation layer and the ultrafiltration membrane support layer is 200 to 300 μm.
Preferably, the thickness of the ultrafiltration membrane layer I and the ultrafiltration membrane layer II is the same.
According to a preferred embodiment of the present invention, in the membrane sheet set, the ultrafiltration membrane separation layers of the ultrafiltration membrane layer I and the ultrafiltration membrane layer II are both located on the side close to the water inlet grid layer.
Preferably, when the ultrafiltration membrane support layer adopted in the membrane stack is formed by stacking (and bonding) the membrane sheets of the ultrafiltration membrane support layer and the membrane sheets of the ultrafiltration membrane separation layer which are independently arranged in sequence during the preparation of the membrane stack, the membrane sheets can be stacked and bonded in the sequence of ultrafiltration membrane support layer I-ultrafiltration membrane separation layer I-water inlet grid layer-ultrafiltration membrane separation layer II-ultrafiltration membrane support layer II-water production grid layer. The ultrafiltration membrane layer I is formed by an ultrafiltration membrane supporting layer I and an ultrafiltration membrane separating layer I, and the ultrafiltration membrane layer II is formed by an ultrafiltration membrane supporting layer II and an ultrafiltration membrane separating layer II.
In the tangential flow membrane group provided by the invention, the material of the hot melt adhesive is not particularly limited. Considering that the membrane set is mainly used in the fields of biology, medicine and the like, disinfection and sterilization (short-time high-temperature) can be carried out during the use process, the hot melt adhesive capable of resisting the short-time high-temperature disinfection and sterilization is preferably adopted in the invention. According to a preferred embodiment of the present invention, wherein the hot melt adhesive is selected from at least one of polypropylene, polyethylene, ethylene-propylene-1-butene copolymer, polyester and polyurethane. Preferably at least one of medical grade polypropylene, polyethylene, ethylene-propylene-1-butene copolymer, polyester and polyurethane
Preferably, the thickness of the hot melt adhesive between two adjacent layers is 0.015-0.4mm, and the width of the edge sealing is 2-10mm. The sealing width refers to the width of the part which is sealed by hot melt glue.
The membrane group provided by the invention can be directly used as a membrane module in a tangential flow filtration system, or a plurality of tangential flow membrane groups can be adopted to form the tangential flow membrane module used in the tangential flow filtration system. Therefore, in the second aspect of the present invention, a tangential flow membrane module is provided, in which the membrane module includes 1 to 30 tangential flow membrane modules stacked in sequence and bonded and sealed, and the tangential flow membrane module is the tangential flow membrane module as described above, and preferably, in the tangential flow membrane module, between two adjacent membrane modules, the water production flow passage holes are aligned with each other (i.e., such that the water inlet flow passages of two adjacent membrane modules are communicated), and the water inlet flow passage holes are aligned with each other (i.e., such that the water production flow passages of two adjacent membrane modules are communicated).
Preferably, the membrane module contains 1-20 tangential flow membrane modules which are stacked and adhesively sealed in sequence.
According to a preferred embodiment of the present invention, in the tangential flow membrane module, the membrane modules are bonded together by a sealant.
Preferably, the sealant is selected from at least one of epoxy, polyurethane and silicone rubber. In view of safety and the like, it is preferable that the sealant is selected from at least one of medical grade epoxy resin, polyurethane and silicone rubber.
In order to bond each membrane group in the membrane module more firmly and make the pressure resistance of the membrane module better, according to a preferred embodiment of the present invention, the sealant may further form a sealing edge with a certain thickness at the periphery of the stacked membrane groups.
Preferably, the width of the edge seal (i.e. the thickness of the sealant forming the edge seal) is 3-10mm.
Fig. 2 exemplarily shows a schematic structural diagram of two adjacent membrane assemblies in the tangential flow membrane assembly including multiple membrane assemblies provided by the present invention (only the adhesion condition of each layer at the water inlet flow channel is shown, and the sealing condition of the hot melt adhesive on the water production flow channel hole of the water inlet grid mesh layer and the water inlet flow channel hole of the water production grid mesh layer are shown, the adhesion condition of each layer at the water production flow channel, the edge sealing adhesion condition of the hot melt adhesive film between each layer, the edge sealing condition of the sealant between two membrane assemblies, and the edge sealing condition of the sealant at the periphery of the membrane assemblies are not shown). Wherein, the liquid to be treated enters from the water inlet channel 1, and after the filtration treatment, the permeate (such as water and the like) flows out from the water production channel 2. In each membrane group, the water inlet flow passage holes of each layer are aligned with each other to form a water inlet flow passage, and the water inlet flow passages of two adjacent membrane groups are aligned with each other, so that the water inlet flow passages of the membrane groups in the membrane modules are communicated; the water producing flow passages of each layer are aligned with each other to form a water producing flow passage, and the water producing flow passages of two adjacent membrane groups are aligned with each other, so that the water inlet flow passages of the membrane groups in the membrane modules are communicated.
In a third aspect, the present invention provides a method of making a tangential flow membrane module, the method comprising:
(1) Preparing a tangential flow membrane group: cutting an ultrafiltration membrane, a water inlet grid, a water production grid and a hot melt adhesive film, stacking the ultrafiltration membrane, the water inlet grid, the ultrafiltration membrane and the hot melt adhesive film in sequence (from top to bottom), wherein the water inlet grid comprises water inlet flow channel holes, the water production grid comprises water production flow channel holes, the ultrafiltration membrane I and the ultrafiltration membrane II both comprise water inlet flow channel holes and water production flow channel holes, and placing the cut hot melt adhesive film between two adjacent layers for edge sealing and bonding the periphery of each layer and the periphery of the water inlet flow channel holes and/or the periphery of the water production flow channel holes;
(2) Preparing a tangential flow membrane module: sequentially stacking and bonding the tangential flow membrane groups obtained in the step (1) by 1-30 in sequence, and bonding and sealing the periphery of the stacked membrane groups by adopting a sealant to form edge sealing.
The step (1) in the method provided by the invention is the method for preparing the tangential flow membrane set, and the materials and characteristics of the membrane set are as described above and are not described again.
In order to simplify the preparation process and reduce the operation difficulty, the ultrafiltration membrane layer I, the water inlet grid layer, the ultrafiltration membrane layer II and the water production grid layer can be cut according to the same model (simultaneously containing the water inlet flow channel holes and the water production flow channel holes) in the step (1), and then when the layers are bonded, the water inlet flow channel holes of the water production grid layer and the water production flow channel holes of the water inlet grid layer are respectively sealed, so that the water inlet grid layer only with the water inlet flow channel holes and the water production grid layer only with the water production flow channel holes are formed. The sealing operation may be performed by cutting the hot melt adhesive film while maintaining the position of the hot melt adhesive film around the corresponding runner hole. Namely, through the hot melt adhesive membrane that remains the position around the runner hole that needs the confined to in bonding process, the hot melt adhesive membrane heats and melts the back, sees through the mesh of graticule mesh, makes the hot melt adhesive after the cooling solidifies seal the runner hole of graticule mesh layer when bonding graticule mesh and adjacent milipore filter layer with it. For example, referring to fig. 2, in one of the membrane groups, the water inlet flow passage holes of the water producing grid layer and the ultrafiltration membrane (support) layer (II) are sealed while the water producing grid layer and the ultrafiltration membrane layer (II) are bonded at positions around the water inlet flow passage holes by hot melt adhesive, and the water producing grid layer and the ultrafiltration membrane layer (II) are not bonded at positions around the water producing flow passage holes. The water production flow passage holes of the water inlet grid layer are sealed while the positions around the water production flow passage holes of the ultrafiltration membrane (separation) layer (I), the water inlet grid layer and the ultrafiltration membrane (separation) layer (II) are bonded through hot melt adhesives, and the positions around the water inlet flow passage holes of the ultrafiltration membrane layer (I), the water inlet grid layer and the ultrafiltration membrane layer (II) are not bonded.
In order to prevent each layer from slipping and deforming during stacking and/or bonding, the ultrafiltration membrane layer I, the water inlet grid layer, the ultrafiltration membrane layer II, the water production grid layer and the hot melt adhesive film between the layers can be fixed in a bonding die by positioning pins during bonding of the layers in the step (1), and then bonding is carried out. Meanwhile, the thickness of the hot melt adhesive between the layers after bonding and the total thickness of the (single) membrane group can be controlled through the bonding die.
The step (2) in the method provided by the invention is the method for preparing the tangential flow membrane module, and the characteristics of the membrane module are as described above and are not described again.
Preferably, in the step (2), 1 to 20 tangential flow membrane groups are sequentially stacked and bonded, and the periphery of the stacked membrane groups is bonded and sealed by using a sealant to form a seal edge, so as to obtain the membrane groups.
Referring to fig. 2, when two adjacent membrane groups are bonded, the water producing grid mesh layer of the previous membrane group and the water inlet flow channel hole of the ultrafiltration membrane (support) layer (I) of the next membrane group are bonded to each other, while the water producing flow channel hole is not bonded.
In order to control the overall thickness of the membrane module, according to a preferred embodiment of the present invention, in step (2), a bonding mold may be used when bonding each membrane module, and the overall thickness of the finally manufactured membrane module may be adjusted and controlled by using the limit of the mold.
In a fourth aspect the present invention provides a tangential flow membrane module obtained by the method as described above. The features of the tangential flow membrane module are as described above and will not be described in detail here.
In a fifth aspect, the present invention provides the use of a tangential flow membrane module or a tangential flow membrane module as described above for the preparation of a pharmaceutical and/or a biological product
In the invention, the application can be that products or intermediate products are filtered, concentrated and purified by adopting the tangential flow filtration system of the tangential flow membrane group or the membrane module provided by the invention in the preparation process of medicines and/or biological products. The device containing the tangential flow membrane assembly or the membrane assembly provided by the invention can be used for performing operations of buffer solution and/or culture solution replacement, culture solution and/or buffer solution heat removal and the like in the preparation process of medicines and/or biological products.
The present invention will be described in detail below by way of examples. It should be understood that the following examples are only intended to further illustrate and explain the contents of the present invention by way of example, and are not intended to limit the present invention.
The materials and reagents used in the following examples are all commercially available.
Example 1
Tangential flow membrane stacks were prepared according to the materials in table 1 and the parameters in table 2.
The weight average molecular weights of the materials of the support layer in Table 1 are respectively: polyethylene terephthalate 2X 10 4 6X 10 Polypropylene 5 Polyethylene 3X 10 5 Polyethylene terephthalate (medical grade) 1X 10 5 Polypropylene (medical grade) 3.2X 10 5 Polyethylene (medical grade) 2.5X 10 5 。
The preparation method comprises the following steps:
referring to the structure of a single membrane set in fig. 2, the ultrafiltration membrane, the water inlet grid and the water production grid are cut into rectangles (with the length of 210mm and the width of 200 mm) with circular water production flow channel holes and circular water inlet flow channel holes at two ends in the long side direction according to the dimensions in table 2, and the hot melt adhesive film is cut according to the shape of each layer and the required edge sealing width. Stacking the water producing layer hot melt adhesive film, the ultrafiltration film layer I, the water inlet layer hot melt adhesive film, the water inlet grid layer, the water inlet layer hot melt adhesive film, the ultrafiltration film layer II, the water producing layer hot melt adhesive film, the water producing grid layer and the water producing hot melt adhesive film in a bonding die in the sequence from top to bottom. And the separation layers of the ultrafiltration membrane layer I and the ultrafiltration membrane layer II are positioned on one side close to the water inlet grid layer. When stacking, the water inlet flow passage holes on each layer are aligned with each other, and the water production flow passage holes are aligned with each other. When one layer of ultrafiltration membrane or grid is stacked, the hot melt adhesive film is used for bonding the ultrafiltration membrane or grid with the membrane or grid positioned at the lower layer. The hot melt adhesive film on the water producing layer is kept on the periphery of the water inlet flow passage hole during cutting, and the hot melt adhesive film on the water inlet layer is kept on the periphery of the water producing flow passage hole during cutting so as to seal the water inlet flow passage hole of the water producing grid mesh layer and the water producing flow passage hole of the water inlet grid mesh layer. For the ultrafiltration membrane layer, separate membrane sheets of the support layer and the separation layer were used (indicated by x in table 1, the material of the ultrafiltration membrane layer used for the unlabelled membrane sheet was compounded by coating before the membrane sheet was prepared), and when the inlet flow channel holes on the water-producing grid were closed, the inlet flow channel holes on the support layer adjacent to it were also closed accordingly.
TABLE 1
TABLE 2
Example 2
The membrane sheet set obtained in example 1 was made into a tangential flow membrane module according to the parameters in table 3. The preparation method comprises the following steps:
and sequentially placing a plurality of membrane groups into a glue injection mold for fixation, injecting sealant to form edge sealing with a certain thickness around the membrane groups by the sealant, and demolding to obtain the membrane module.
TABLE 3
Test example 1
A simulated concentration test was performed using the tangential flow membrane module prepared in example 2 to test the filtration effect of the tangential flow membrane module provided by the present invention. The specific method comprises the following steps:
the tangential flow membrane module prepared in example 2 was loaded into a tangential flow filtration system, and 500mL of bovine serum albumin solution (bovine serum albumin content 1000 mg/L) was filtered and concentrated under a temperature of 25 ℃ and a pressure of 0.1MPa. In the tangential flow filtration system, a bovine serum albumin solution to be filtered, which is filled in a feed tank, enters a membrane package containing a tangential flow membrane component under the action of a feed pump, the concentrated bovine serum albumin solution after filtration and concentration treatment enters a concentrated liquid tank, and the filtered water enters a permeation liquid tank. The results are detailed in Table 4, wherein the liquid recovery is the sum of the liquid collected through the tank and the concentrate tank.
TABLE 4
As can be seen from the data in Table 4, the tangential flow membrane module provided by the invention has the advantages of high filtration speed and high liquid recovery amount which is more than 90% when in use, which indicates that the membrane module can meet the requirements of filtration, concentration, purification and other operations when a tangential flow filtration system is adopted for preparing medicines and/or biological products.
The preferred embodiments of the present invention have been described above in detail, but the present invention is not limited thereto. Within the scope of the technical idea of the invention, many simple modifications can be made to the technical solution of the invention, including combinations of various technical features in any other suitable way, and these simple modifications and combinations should also be regarded as the disclosure of the invention, and all fall within the scope of the invention.
Claims (12)
1. The utility model provides a tangential flow diaphragm group, its characterized in that, diaphragm group is including the milipore filter layer I that piles up in proper order, the graticule mesh layer of intaking, milipore filter layer II and the graticule mesh layer of producing, the graticule mesh layer of intaking is including the inflow passageway hole, it is including producing the water flow path hole to produce the water grid layer, ultrafiltration rete I and ultrafiltration rete II all include the inflow passageway hole and produce the water flow path hole, and all adopt the hot melt adhesive to carry out the banding and bond around each layer and inflow passageway hole and/or producing the water flow path hole.
2. The tangential flow membrane set of claim 1, wherein the water inlet flow passage hole and the water production flow passage hole on the ultrafiltration membrane layer I and the ultrafiltration membrane layer II are respectively positioned at two ends of the membrane;
and/or the water inlet runner holes of the water inlet grid net layer and the water production runner holes of the water production grid net layer are arranged in a mutually crossed manner;
preferably, the water inlet runner holes on the water inlet grid layer, the ultrafiltration membrane layer I and the ultrafiltration membrane layer II are respectively positioned at the same position and have the same size, and the water inlet runner holes between the upper layer and the lower layer are aligned with each other;
preferably, the water production channel holes on the water production lattice net layer, the ultrafiltration membrane layer I and the ultrafiltration membrane layer II are respectively positioned at the same position and have the same size, and the water production channel holes between the upper layer and the lower layer are arranged in an aligned manner;
more preferably, the size of the water inlet flow passage hole is larger than that of the water production flow passage hole, and the diameter of the water inlet flow passage hole is preferably 1.2-1.5 times of that of the water production flow passage hole;
more preferably, the number of the water inlet flow passage holes of the ultrafiltration membrane layer I is the same as that of the water production flow passage holes, and the number of the water inlet flow passage holes is preferably 2 to 10 respectively.
3. The tangential flow membrane group according to claim 1, wherein the water inlet mesh layer is made of polypropylene and/or polyethylene terephthalate;
and/or the grid material adopted by the water producing grid layer is polypropylene and/or polyethylene terephthalate;
preferably, the mesh number of the meshes adopted by the water inlet mesh layer is 20-80 meshes;
preferably, the mesh number of the mesh adopted by the water producing mesh layer is 20-100 meshes;
more preferably, the mesh number of the grids adopted by the water producing grid layer is 1.3-5 times that of the grids adopted by the water inlet grid layer;
more preferably, the thickness of the water inlet gridding layer is 120-150 μm;
more preferably, the thickness of the water-producing lattice network layer is 140-200 μm.
4. The tangential flow membrane module of claim 1, wherein the ultrafiltration membrane layer I and ultrafiltration membrane layer II comprise an ultrafiltration membrane separation layer and an ultrafiltration membrane support layer, respectively;
preferably, the thickness of the ultrafiltration membrane layer I is 200-300 μm;
preferably, the thickness of the ultrafiltration membrane layer II is 200-300 μm;
preferably, the ultrafiltration membrane support layer material is selected from at least one of polyethylene terephthalate, polypropylene and polyethylene;
preferably, the ultrafiltration membrane separation layer material is selected from at least one of polyvinylidene fluoride, polyether sulfone and regenerated cellulose;
more preferably, the weight average molecular weight of the ultrafiltration membrane support layer material is 2 × 10 4 -6×10 5 ；
More preferably, the thickness ratio of the ultrafiltration membrane separation layer to the ultrafiltration membrane support layer is 1:1-3.
5. The tangential flow membrane array of claim 1, wherein said hot melt adhesive is selected from at least one of polypropylene, polyethylene, ethylene-propylene-1-butene copolymer, polyester, and polyurethane;
preferably, the thickness of the hot melt adhesive between two adjacent layers is 0.015-0.4mm, and the width of the edge sealing is 2-10mm.
6. A tangential flow membrane module, characterized in that the membrane module comprises 1-30 tangential flow membrane groups which are stacked in sequence and are bonded and sealed, wherein the tangential flow membrane groups are the tangential flow membrane groups as claimed in any one of claims 1-5, preferably, in the tangential flow membrane module, between two adjacent membrane groups, water production flow passage holes are arranged in alignment with each other, and water inlet flow passage holes are arranged in alignment with each other.
7. A method of making a tangential flow membrane module, the method comprising:
(1) Preparing a tangential flow membrane group: cutting an ultrafiltration membrane, a water inlet grid, a water production grid and a hot melt adhesive film, and stacking the ultrafiltration membrane, the water inlet grid, the ultrafiltration membrane and the hot melt adhesive film in sequence according to an ultrafiltration membrane layer I, a water inlet grid layer, an ultrafiltration membrane layer II and a water production grid layer, wherein the water inlet grid layer comprises water inlet flow passage holes, the water production grid layer comprises water production flow passage holes, the ultrafiltration membrane layer I and the ultrafiltration membrane layer II both comprise water inlet flow passage holes and water production flow passage holes, and the cut hot melt adhesive film is placed between two adjacent layers for bonding the periphery of each layer and the periphery of the water inlet flow passage holes and/or the periphery of the water production flow passage holes in a sealing manner;
(2) Preparing a tangential flow membrane module: sequentially stacking and bonding the tangential flow membrane groups obtained in the step (1) by 1-30 in sequence, and bonding and sealing the periphery of the stacked membrane groups by adopting a sealant to form edge sealing.
8. The method according to claim 7, wherein in the step (1), the water inlet runner hole and the water production runner hole on the ultrafiltration membrane layer I and the ultrafiltration membrane layer II are respectively positioned at two ends of the membrane sheet;
preferably, the water inlet flow passage holes of the water inlet grid layer and the water production flow passage holes of the water production grid layer are arranged in a mutually crossed and aligned mode;
preferably, the water inlet runner holes on the water inlet grid layer, the ultrafiltration membrane layer I and the ultrafiltration membrane layer II are respectively positioned at the same position and have the same size, and the water inlet runner holes between the upper layer and the lower layer are aligned up and down when being stacked;
preferably, the water production runner holes in the water production grid layer, the ultrafiltration membrane layer I and the ultrafiltration membrane layer II are respectively positioned at the same position and have the same size, and the water production runner holes in the upper layer and the lower layer are aligned up and down when being stacked;
more preferably, the size of the water inlet flow passage hole is larger than that of the water production flow passage hole, and the size of the water inlet flow passage hole is 1.2-1.5 times that of the water production flow passage hole;
more preferably, the number of the water inlet flow passage holes of the ultrafiltration membrane layer I is the same as the number of the water production flow passage holes, and is preferably 2-10 respectively.
9. The method according to claim 7 or 8, wherein the water inlet grid layer adopts a grid made of polypropylene and/or polyethylene terephthalate;
and/or the material of the grid adopted by the water producing grid layer is polypropylene and/or polyethylene terephthalate;
and/or the ultrafiltration membrane layer I and the ultrafiltration membrane layer II are made of organic ultrafiltration membranes with supporting layers;
and/or the material of the hot melt adhesive film is selected from at least one of polypropylene, polyethylene, ethylene-propylene-1-butylene copolymer, polyester and polyurethane;
preferably, the mesh number of the meshes adopted by the water inlet mesh layer is 20-100 meshes;
preferably, the mesh number of the mesh adopted by the water producing mesh layer is 20-100 meshes;
preferably, the material of the support layer is selected from at least one of polyethylene terephthalate, polypropylene and polyethylene;
preferably, the organic ultrafiltration membrane material is selected from at least one of polyvinylidene fluoride, polyethersulfone and regenerated cellulose;
preferably, the thickness of the hot melt adhesive film is 0.015-0.4mm, and the edge sealing width is 2-10mm
More preferably, the mesh number of the water producing grid is 1.3-5 times of that of the water inlet grid;
more preferably, the support layer material has a weight average molecular weight of 2 × 10 4 -6×10 5 ；
More preferably, the thickness ratio of the ultrafiltration membrane separation layer to the ultrafiltration membrane support layer is 1:1-3.
10. The method according to claim 9, wherein the sealant material used in step (2) is at least one of epoxy resin, polyurethane and silicone rubber;
preferably, the width of the sealed edge formed by the sealant is 3-10mm;
more preferably, in the tangential flow membrane module, between two adjacent membrane plate groups, the water production flow passage holes are aligned with each other, and the water inlet flow passage holes are aligned with each other.
11. A tangential flow membrane module obtained by the process according to any one of claims 7 to 10.
12. Use of a tangential flow membrane module according to any of claims 1 to 5 or a tangential flow membrane module according to claim 6 or 11 for the preparation of a pharmaceutical and/or biological product.
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