CN115836710B - Composite preparation for improving animal reproductive performance and application thereof - Google Patents
Composite preparation for improving animal reproductive performance and application thereof Download PDFInfo
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- CN115836710B CN115836710B CN202211618840.5A CN202211618840A CN115836710B CN 115836710 B CN115836710 B CN 115836710B CN 202211618840 A CN202211618840 A CN 202211618840A CN 115836710 B CN115836710 B CN 115836710B
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Abstract
The invention discloses a compound preparation for improving animal reproductive performance and application thereof, belonging to the field of animal reproduction. The invention aims to solve the problem of reduced reproductive performance caused by cold stress at low temperature, in particular to a temperate variety introduced into a cold region, such as Hu sheep. The invention comprises the following components in parts by mass: 5 to 25 parts of alpha-ketoglutarate, 0.025 to 0.100 part of zinc lysine, 5 to 10 parts of vitamin C and 1 to 5 parts of vitamin E. The compound preparation has the effects of improving the testosterone content, sperm motility, total antioxidant capacity, catalase activity, glutathione peroxidase activity and superoxide dismutase activity of the ram, having no influence on sperm deformity rate and obviously reducing malondialdehyde content.
Description
Technical Field
The invention belongs to the field of animal reproduction, in particular to a composite preparation for improving animal reproduction performance, and application of the composite preparation for improving animal reproduction performance, wherein the composite preparation is used in feed for improving animal reproduction capacity for promoting cold stress resistance and improving immunity and oxidation resistance of an organism; is especially suitable for improving the reproductive performance of the cold stress resistance of the Hu sheep isothermal zone variety introduced into the cold region.
Background
The Hu sheep is native to the Taihu river basin in south China, is a sheep variety with dual purposes of skin and meat, and has the advantages of early sexual maturity, oestrus in four seasons, fast growth and development, coarse feeding resistance, high slaughter rate and the like. The Hu sheep is introduced into northeast cold regions due to the excellent characters, but the great difference of environment and climate leads the Hu sheep to be in a cold stress state, so that the immunity and oxidation resistance are low, and the reproductive performance is reduced; the method is characterized by slow ram growth speed, bad oestrus state, reduced ewe embryo, low lamb birth weight and the like. Meanwhile, along with the 'forbidden' becoming a key guiding direction in the field of livestock production, reproductive capacity improvement through a nutrition regulation technology becomes an important technical route. Therefore, the development of the effective cold region Hu sheep reproductive performance improvement promotion composite preparation for resisting cold stress has practical positive significance.
At present, the effects of alpha-ketoglutaric acid and zinc lysine on relieving the reduction of the reproductive performance of Hu sheep under the condition of cold stress are not reported yet.
Disclosure of Invention
The invention aims to provide a compound preparation which has simple formula and safe use and can resist the degradation of reproductive performance of Hu sheep in cold areas caused by cold stress.
In order to realize the technical problems, the invention adopts the following technical scheme:
the invention aims to provide a composite preparation for improving animal reproductive performance, which comprises the following components in parts by weight: 5-25 parts of alpha-ketoglutaric acid, 0.025-0.100 part of zinc lysine, 5-10 parts of vitamin C and 1-5 parts of vitamin E. Preferably: 15-20 parts of alpha-ketoglutaric acid, 0.025-0.050 part of zinc lysine, 6-10 parts of vitamin C and 2-5 parts of vitamin E. More preferably: 20 parts of alpha-ketoglutaric acid, 0.050 parts of zinc lysine, 8 parts of vitamin C and 4 parts of vitamin E.
The application of the composite preparation is that the composite preparation is used as an additive of cold stress resistant feed for male animals; or as an active ingredient of a cold stress resistant premix feed for animal feeding.
The compound preparation is used for enhancing the animal semen activity and is applied to animal feeding to improve the reproductive capacity of male animals in cold areas.
The compound preparation is used for enhancing the testosterone content of animals and is applied to animal feeding to improve the reproductive capacity of male animals in cold areas.
The compound preparation is used for reducing animal sperm malformation, and is applied to animal feeding to improve reproductive capacity of male animals in cold regions.
The application of the composite preparation is that the composite preparation is used for improving the immunity and/or the oxidation resistance of animals and is applied to animal feeding.
Further defined, the amount of the compound preparation is 5 kg-20 kg of the compound preparation added to each ton of animal feed.
Further defined, the animal is a mammal, such as a Hu sheep.
Alpha-ketoglutarate is an important transition product and speed limiting step of tricarboxylic acid circulation of animal bodies, and is also a key intermediate of various physiologically active substances. Besides, the alpha-ketoglutarate also has various functions of participating in protein synthesis of organisms, reducing inflammatory reaction of the organisms, improving anti-stress capability, reducing diarrhea of young animals, increasing intestinal microorganism abundance, reducing feed conversion ratio, enhancing antioxidant enzyme activity, scavenging free radicals, improving utilization rate of various elements and the like. The alpha-ketoglutarate is further metabolized into succinyl-CoA under the action of alpha-ketoglutarate dehydrogenase and enters a new metabolic cycle, and the energy and various metabolic substances generated in the process ensure the normal growth and proliferation process of cells. In addition, the alpha-ketoglutaric acid has better stability and solubility than glutamine, and can not cause extra ammonia nitrogen residue after meeting the normal requirement of the organism, thus having less harm to the organism.
Alpha-ketoglutaric acid is also a keto acid product of glutamic acid deamination, and is one of ketoglutaric acid derivatives. Alpha-ketoglutarate can form L-glutamic acid through transamination and enter nitrogen metabolism, and is a key node for connecting carbon and nitrogen metabolism of cells. The position of alpha-ketoglutarate in the tricarboxylic acid cycle is between isocitrate and succinyl-CoA. After glucose is transported into cells, pyruvic acid is produced through glycolysis process, and then the glucose enters tricarboxylic acid cycle in the form of pyruvic acid, and AKG is gradually formed under the action of pyruvate dehydrogenase system, citrate synthase, aconitase and isocitrate dehydrogenase in turn in the cycle. Under low temperature or cold stress conditions, the body's demand for thermoregulation increases, while the operation of the immune system requires a large energy supply as well as the initiation of immune responses. The body must further limit the internal energy supply of the immune system, provided that the energy metabolism state of the body is unchanged. The body must further limit the internal energy supply of the immune system, provided that the energy metabolism state of the body is unchanged. Meanwhile, the metabolism speed of the organism is increased, so that the mitochondrial activity is increased, the yield of free radicals is increased, the oxidation state of the organism is increased, and the reproductive performance is further influenced.
Zinc lysine is a five-membered ring chelate formed by lysine and zinc, and lysine is one of 8 essential amino acids of mammals, is an important nutrient for normal metabolism of a human body, and plays an important role in maintaining nitrogen balance of the human body. Zinc is one of 14 microelements necessary for mammals, and has multiple physiological functions of accelerating growth and development, regulating organism immunity, etc. The amino acid microelement chelate has the advantages of good chemical stability, easy digestion and absorption, high biological utilization rate, strong anti-interference capability and no toxicity, can effectively improve the animal productivity and organism immunity, and has the functions of supplementing microelement nutrition and amino acid reinforcing agent.
Vitamin C, also called ascorbic acid, is one of important water-soluble vitamins, and can effectively remove active oxygen in cells, avoid lipid peroxidation and reduce the oxidative stress degree of organisms. Can also maintain the activity of glutathione which is an important antioxidant of the organism and recover the reduction of active vitamin E caused by capturing free radicals. Vitamin C directly eliminates free radicals and active oxygen; down-regulating ROS-producing enzyme activity; the activity of other antioxidant substances is improved; four paths of Nrf2 related signal paths are activated to realize the antioxidation function.
Vitamin E, also known as tocopherol, is one of the important fat-soluble vitamins, has stronger free radical scavenging ability, and can directly participate in free radical scavenging, or promote the activity of antioxidant enzyme to indirectly participate in free radical scavenging. And has the functions of protecting sulfhydryl enzyme, resisting senility, preventing cancer, etc. The proper vitamin E supplement for male animals can promote testis development, maintain sperm motility and number, avoid sperm malformation and semen quality degradation, etc. Vitamin E ingested by animals is hydrolyzed by nonspecific esterase in intestinal tract and absorbed by intestinal epithelial cells under the action of cholesterol phospholipid and the like to form chylomicron which reaches liver, and then is transported to each target organ of the body through body fluid regulation and blood circulation, and when vitamin E is not ingested enough, the body can preferentially consume the tocopherol which is stored in the liver, spleen and blood for standby.
The invention has the following beneficial effects.
The invention uses alpha-ketoglutaric acid, zinc lysine, vitamin C and vitamin E for compatibility of the compound preparation for the first time, under the synergistic effect, the invention not only can improve the immunity and the antioxidation capability of animals in cold regions under the state of cold stress, but also can effectively improve the reproductive performance index including sperm quality, and has positive significance for improving the feeding and production of animals in cold regions (especially Hu sheep).
The compound preparation for improving and promoting the reproductive performance of the animals in cold areas (especially Hu sheep) with cold stress resistance can improve the reproductive performance of the animals (especially Hu sheep) when the compound preparation is used for raising the animals in cold areas (especially Hu sheep).
The compound preparation for improving and promoting the reproductive performance of animals (especially Hu sheep) in cold areas (especially Hu sheep) with cold stress resistance can improve the immunity and the oxidation resistance of the animals (especially Hu sheep).
Detailed Description
The invention will be further illustrated with reference to specific examples. It is to be understood that these examples are illustrative of the present invention and are not intended to limit the scope of the present invention.
The following detailed description of the present invention is provided for purposes of illustration and is not to be construed as limiting the invention, as the examples, without regard to specific techniques or conditions, may be carried out in accordance with the techniques or descriptions set forth in the literature, and the reagents or instruments used, without regard to sources, may be carried out using commercially available conventional products.
Example 1: the components and the proportions of the compound preparation for improving and promoting the reproductive performance of the Hu sheep in cold areas with cold stress resistance are shown in Table 1;
table 1 shows the raw material composition (parts by mass) of the Hu sheep reproductive performance improvement promotion composite preparation in cold areas with cold stress resistance
The preparation method comprises the following steps: and accurately weighing the raw materials according to the composition of the raw materials, and placing the raw materials into a stirrer for fully and uniformly mixing to obtain the compound preparation for improving the reproductive performance of the Hu sheep in cold areas with cold stress resistance.
Application and effect measurement of composite preparation for improving reproductive performance of Hu sheep in cold areas with cold stress resistance
According to the feeding practice, a concentrate ration containing 1.0% of the compound preparation is prepared, and a feed granulator is used for preparing 0.5cm of granulated feed. The ram with good body condition, no disorder of fur and healthy individual is randomly divided into 4 groups of 8 replicates.
Daily at 07:00 and 15:00, free drinking water is used during feeding, and the ambient temperature is detected. Venous blood is collected by a venipuncture method on days 30, 45 and 60 respectively, heparin is anticoagulated, and supernatant plasma is collected by centrifugal treatment by using a centrifugal machine (3500 rpm,10 min) and is preserved at-20 ℃ for detection. Semen is collected by an electric stimulation method at 30 days, 45 days and 60 days respectively, and is immediately put into a constant temperature box at 37 ℃ for temporary storage after collection, and is sent to a laboratory for detection within 30 minutes.
TABLE 2 influence of composite preparation on ram reproductive performance by improving and promoting reproductive performance of Hu sheep in cold region with cold stress resistance
The same column of data shoulder marks are different in letters and represent significant differences (P < 0.05)
Table 2 shows the effect of the compound preparation on the breeding performance of the ram, wherein the improvement of the breeding performance of the Hu sheep in cold areas with cold stress resistance is promoted. As can be seen from table 2, the testosterone content of the compound preparation II is significantly higher than that of the compound preparation II, the compound preparation III and the control group, and the testosterone content of the compound preparation II and the compound preparation III is significantly higher than that of the control group. The sperm motility of the compound preparation II and the compound preparation III is obviously higher than that of the compound preparation I and the control group, and the sperm motility of the compound preparation I and the control group are obviously higher. There was no significant difference in sperm malformation rate between groups. The result shows that the compound preparation for improving and promoting the reproductive performance of the Hu sheep in cold areas with cold stress resistance can obviously improve the testosterone content of the ram, improve the sperm motility and not influence the sperm deformity rate.
TABLE 3 influence of composite preparation on oxidation resistance of ram by improving reproductive performance of Hu sheep in cold region with cold stress resistance
The same column of data shoulder marks are different in letters and represent significant differences (P < 0.05)
Table 3 shows the effect of the compound preparation on the oxidation resistance of the ram on improving the reproductive performance of the Hu sheep in cold areas with cold stress resistance. From Table 3, it is clear that the compound preparation for improving and promoting the reproductive performance of the Hu sheep in cold areas with cold stress resistance can remarkably improve the total antioxidant capacity, the catalase activity, the glutathione peroxidase activity and the superoxide dismutase activity of the ram, and meanwhile, the malondialdehyde content is remarkably reduced.
TABLE 4 influence of composite preparation on immunity of ram by improving reproductive performance of Hu sheep in cold region with cold stress resistance
Table 4 shows the effect of the compound preparation on the immunity of the ram, wherein the improvement of the reproductive performance of the Hu sheep in cold areas with cold stress resistance is promoted. From Table 4, it is clear that the compound preparation for improving and promoting the reproductive performance of the Hu sheep in cold areas with cold stress resistance can remarkably improve the melatonin level of the ram and remarkably reduce the content of tumor necrosis factor-alpha.
The effect of different doses of alpha-ketoglutaric acid and zinc lysine was examined by the following experiments
The grouping is shown in Table 5:
table 5 shows the optimal dose verification grouping for alpha-ketoglutarate and zinc lysinate
According to the feeding practice, the alpha-ketoglutaric acid and zinc lysine with specific weights are weighed and fully mixed with the concentrate ration respectively, and the mixture is prepared into 0.5cm pellet feed by using a feed granulator. The ram with good body condition, no disorder of fur and healthy individual was randomly divided into 7 groups of 6 replicates.
Daily at 07:00 and 15:00, free drinking water is used during feeding, and the ambient temperature is detected. Venous blood was collected by venipuncture on day 60, heparin was anticoagulated, and the supernatant plasma was collected by centrifugation at-20℃using a centrifuge (3500 rpm,10 min) and stored for detection. Semen is collected by an electric stimulation method on the 60 th day, and is immediately put into a constant temperature box at 37 ℃ for temporary storage after collection, and is sent to a laboratory for detection within 30 min.
Table 6 shows the effect of alpha-ketoglutarate and zinc lysinate on ram reproductive performance, respectively
The same column of data is marked with different acronyms (P < 0.05), capital letters indicate a-ketoglutarate group, and lowercase letters indicate zinc lysine group.
Table 6 shows the effect of alpha-ketoglutarate and zinc lysinate on ram reproductive performance, respectively. As can be seen from table 6, the testosterone levels were significantly higher in the α -ketoglutarate group than in the control group, wherein the α -ketoglutarate I group was significantly higher than in the α -ketoglutarate III group; the testosterone levels of the zinc lysine group are all significantly higher than those of the control group, and the testosterone levels of the zinc lysine group II are significantly higher than those of the zinc lysine group I and the zinc lysine group II. The sperm motility of the alpha-ketoglutarate group and the zinc lysine group is not significantly different from that of the control group.
Table 7 shows the effect of alpha-ketoglutarate and zinc lysinate on the antioxidant capacity of ram
The same column of data is marked with different acronyms (P < 0.05), capital letters indicate a-ketoglutarate group, and lowercase letters indicate zinc lysine group.
Table 7 shows the effect of alpha-ketoglutarate and zinc lysinate on the antioxidant capacity of ram, respectively. As can be seen from table 7, the total antioxidant activity of the α -ketoglutarate group is significantly higher than that of the control group, and the α -ketoglutarate group II is significantly higher than that of the α -ketoglutarate group I and the α -ketoglutarate group III; the total antioxidant activity of the zinc lysine group is obviously higher than that of the control group, and the zinc lysine group II and the zinc lysine group III are obviously higher than that of the zinc lysine group I. The activity of the catalase of the alpha-ketoglutarate group is obviously higher than that of the control group, and the activity of the alpha-ketoglutarate group II is obviously higher than that of the alpha-ketoglutarate group I and the alpha-ketoglutarate group III; zinc lysine group catalase activity was significantly higher than control group, zinc lysine group II and zinc lysine group III were significantly higher than zinc lysine group I. The alpha-ketoglutarate and the zinc lysine can enhance the activity of glutathione peroxidase, and the alpha-ketoglutarate III group and the zinc lysine II group are obviously superior to the control group. The superoxide dismutase activities of the alpha-ketoglutarate group and the zinc lysinate group are obviously higher than those of the control group, but no obvious difference exists between the groups. The malondialdehyde level of the alpha-ketoglutarate group is obviously lower than that of the control group, and the alpha-ketoglutarate II group and the alpha-ketoglutarate III group are obviously lower than that of the alpha-ketoglutarate I group; zinc lysine group III malondialdehyde levels were significantly lower than control.
Table 8 shows the effect of alpha-ketoglutarate and zinc lysinate on the immune competence of ram, respectively
The same column of data is marked with different acronyms (P < 0.05), capital letters indicate a-ketoglutarate group, and lowercase letters indicate zinc lysine group.
Table 8 shows the effect of alpha-ketoglutarate and zinc lysinate on the immunological competence of ram, respectively. As can be seen from table 8, the levels of melatonin were significantly higher in the α -ketoglutarate group than in the control group, wherein the α -ketoglutarate group II was significantly higher than in the α -ketoglutarate group II and the α -ketoglutarate group III; the melatonin level of the zinc lysine group is obviously higher than that of the control group, and the melatonin level of the zinc lysine group II and the melatonin level of the zinc lysine group III are obviously higher than that of the zinc lysine group I. The alpha-ketoglutarate group tumor necrosis factor alpha level is obviously lower than that of the control group, wherein the alpha-ketoglutarate II group and the alpha-ketoglutarate III group are obviously lower than that of the alpha-ketoglutarate I group; the tumor necrosis factor alpha of the zinc lysine group is obviously lower than that of the control group, and the zinc lysine group II and the zinc lysine group III are obviously higher than that of the zinc lysine group I.
Thus, the single addition of alpha-ketoglutarate and zinc lysine can have beneficial effects on the reproductive performance, antioxidant capacity and immunity of ram.
The foregoing is merely illustrative of the preferred embodiments of the present invention and is not intended to limit the embodiments of the present invention, and those skilled in the art can easily make corresponding variations or modifications according to the main concept and spirit of the present invention, so the protection scope of the present invention shall be defined by the claims.
Claims (6)
1. The composite preparation for improving the reproductive performance of the Hu sheep is characterized by comprising the following components in parts by weight:
2. use of the composite preparation according to claim 1 as an additive for cold stress resistant feed for male Hu sheep; or used as an effective component of cold stress resistant premix feed and applied to the feeding of Hu sheep.
3. The use of the composite preparation according to claim 1, wherein the composite preparation is a preparation for enhancing animal semen activity and is applied to the breeding of Hu sheep to improve the reproductive capacity of male Hu sheep in cold regions.
4. The use of the composite preparation according to claim 1, wherein the composite preparation is a preparation for enhancing testosterone content in animals, and is used in sheep raising in a Hu sheep to improve reproductive capacity of male Hu sheep in cold regions.
5. The use of the composite preparation according to claim 1, wherein the composite preparation is a preparation for improving the immunity and/or the oxidation resistance of animals, and is applied to the breeding of Hu sheep.
6. The use according to any one of claims 2 to 5, wherein the amount of the compound preparation is 5 kg to 20 kg per ton of the feed for Hu sheep.
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Citations (4)
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| CN104041707A (en) * | 2014-06-13 | 2014-09-17 | 沈阳农业大学 | Taurine compound preparation for improving semen quality and sexual capacity of sire/male poultry |
| CN106562060A (en) * | 2016-11-04 | 2017-04-19 | 湖北博大生物股份有限公司 | Feed additive for increasing stock boar seminal fluid quality |
| CN108542899A (en) * | 2018-06-07 | 2018-09-18 | 华南农业大学 | Application of the α-ketoglutaric acid in terms of improving obese animal Thermogenesis and reducing body fat content |
| CN111249265A (en) * | 2020-03-26 | 2020-06-09 | 华南农业大学 | α application of short-chain dicarboxylic acid substance in improving animal reproductive capacity |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9781919B2 (en) * | 2011-06-01 | 2017-10-10 | Inguran, Llc | Compositions and methods for improving the quality of processed sperm |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104041707A (en) * | 2014-06-13 | 2014-09-17 | 沈阳农业大学 | Taurine compound preparation for improving semen quality and sexual capacity of sire/male poultry |
| CN106562060A (en) * | 2016-11-04 | 2017-04-19 | 湖北博大生物股份有限公司 | Feed additive for increasing stock boar seminal fluid quality |
| CN108542899A (en) * | 2018-06-07 | 2018-09-18 | 华南农业大学 | Application of the α-ketoglutaric acid in terms of improving obese animal Thermogenesis and reducing body fat content |
| CN111249265A (en) * | 2020-03-26 | 2020-06-09 | 华南农业大学 | α application of short-chain dicarboxylic acid substance in improving animal reproductive capacity |
Non-Patent Citations (1)
| Title |
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| "α-酮戊二酸及其生理作用"，付莹等，《湖南饲料》，2017年第5期，第31-33页;付莹等;《湖南饲料》(第5期);第31-33页 * |
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