CN1158093C - Medicine composition containing yak bone for treating rhenmatism and method for making same - Google Patents
Medicine composition containing yak bone for treating rhenmatism and method for making same Download PDFInfo
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- CN1158093C CN1158093C CNB011340614A CN01134061A CN1158093C CN 1158093 C CN1158093 C CN 1158093C CN B011340614 A CNB011340614 A CN B011340614A CN 01134061 A CN01134061 A CN 01134061A CN 1158093 C CN1158093 C CN 1158093C
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Abstract
The present invention discloses a medicine composition which comprises the traditional Tibet medicine of yak bone, lamiophlomis rotata kudo and snow lotus herb and the traditional Chinese medicine of mistletoe, carthamus flower and cinnamon twig and treats rhenmatism. By extraction and separation, the medicine composition has the synergistic effect of dispelling wind, eliminating dampness, promoting blood circulation, dredging the meridian, warming the channels and stopping pain and effectively treats rheumatism and wind-dampness arthralgia syndromes.
Description
Technical field: the present invention relates to treat rheumatismal pharmaceutical composition that contains the Tibet yak bone and preparation method thereof, especially traditional Tibetan medicine Os Bovis grunniens extract and Chinese medicine are carried out prescription, adopt extraction and separation process, the rheumatismal medicine of preparation treatment.
Background technology: report that according to statistics there is the arthritis patient in the U.S. more than 2,000 ten thousand.China's Epidemiological study shows, suffers from rheumatismal number and account for 19.53% of total population.Rheumatism is to become estranged owing to energy and blood of human body battalion defends, experience pathogens such as wind, cold, wet, heat, invasion and attack skin meridians, muscles and bones blood vessels, pathogen conflicting with vital QI, the resistance of QI and blood numbness, appearance with pain, the swelling of limbs joint, weighing, symptoms such as numbness, distortion, stiff and limitation of activity are feature, involve internal organs when serious, cause a class disease of function activity imbalance.The rheumatismal medicine of clinical treatment mainly contains hormone, Radix Tripterygii Wilfordii tablet, Wang numbness electuary etc., but these medicines exist the restriction in the application or take for a long time after can produce dependency, and the toxic and side effects of bringing out other pathological changes is arranged.
Os Bovis grunniens is the dry bone that Bovidae (Bovidae) animal yak (Bos grunniens L) is rejected the muscle mesentery.The Tibetan medicine with its calcining, be ground into smalls, making pellets by mixing medical powder with honey is used for the treatment of Fengshi Guanjie pain.Tibetan medicine and Tibet national folk are endured diseases such as cream is used for children's's rickets and the muscles and bones flaccidity is soft, osteodynia with it.Modern analysis shows that Os Bovis grunniens contains multiple element such as calcium, copper, zinc and osseocolla peptide, polysaccharide etc., and its component content that promotes skeleton development and bone injury healing is than general herbivore skeleton height.Therefore, in recent years, the research that utilizes Os Bovis grunniens to make the bone strengthening health product constantly occurs.As: patent application " yak marrow tonic powder and processing method thereof " (CN1259384), its component is corn, Mel, soybean protein, yak calcium king powder, Poria, chocolate, Lentinus Edodes, Semen Armeniacae Amarum, Radix Glycyrrhizae etc.Patent application " a kind of Medulla Bovis grunniens powder health food and manufacture method thereof " (CN1244425), it consists of Medulla Bovis grunniens powder and Herba Herminii powder etc.(CN1215593), its component is bone meal, dextrinosan, vitamin D, beta-carotene in patent application " high active calcium tablet and processing technology ".The above-mentioned patent that contains Os Bovis grunniens is health product.Because medicine not only requires composition clear and definite, reasonable recipe, and require to prove evident in efficacy with experimental data, difficulty is bigger, so do not see as yet that so far having with the Os Bovis grunniens is the medicine that raw material is made.
Summary of the invention: the technical problem to be solved in the present invention is, how according to theory of Chinese medical science, traditional Tibetan medicine Os Bovis grunniens, Radix Lamiophlomidis Rotatae and Chinese medicine carried out prescription, and by the removing dampness of dispeling the wind, promoting blood circulation to remove obstruction in the collateral, antalgic are treated rheumatic Bi syndrome effectively.Simultaneously, the extraction and separation process of design system makes clear and definite, the enrichment of effective site, make the present invention treat rheumatismal pharmaceutical effectiveness significantly, stable.
Technical scheme of the present invention is as follows.
The rheumatismal pharmaceutical composition of a kind of treatment is characterized in that comprising following raw material: Os Bovis grunniens, Herba Saussureae Involueratae, Radix Lamiophlomidis Rotatae, Herba Taxilli, Flos Carthami, Ramulus Cinnamomi.
Its weight proportion can be Os Bovis grunniens 1-60, Herba Saussureae Involueratae 1-20, Radix Lamiophlomidis Rotatae 1-20, Herba Taxilli 1-20, Flos Carthami 1-20, Ramulus Cinnamomi 1-20.
Its weight proportion also can be Os Bovis grunniens 10-45, Herba Saussureae Involueratae 5-12, Radix Lamiophlomidis Rotatae 2-10, Herba Taxilli 5-12, Flos Carthami 5-10, Ramulus Cinnamomi 5-10.
Its preferably weight proportion be: Os Bovis grunniens 40, Herba Saussureae Involueratae 10, Radix Lamiophlomidis Rotatae 5, Herba Taxilli 10, Flos Carthami 5, Ramulus Cinnamomi 10.
The rheumatismal pharmaceutical composition of above-mentioned treatment is characterized in that described preparation can be any preparation on the pharmaceutics.
The rheumatismal preparation of compositions method of a kind of treatment is characterized in that comprising the steps:
Get Os Bovis grunniens, Herba Saussureae Involueratae, Radix Lamiophlomidis Rotatae, Herba Taxilli, Flos Carthami, Ramulus Cinnamomi, use water extraction, concentrate, solid-liquid separation, drying is granulated, and is encapsulated.
Os Bovis grunniens, water extraction such as Herba Saussureae Involueratae can adopt water at low temperature to extract and/or decocting boils.Solid-liquid separation can adopt centrifugalize and/or membrance separation and/or filtration.Drying can adopt oven drying and/or vacuum drying and/or lyophilization and/or spray drying.Granulation can be adopted wet granulation and/or dry granulation.
Perhaps adopt the method that comprises the steps: the Os Bovis grunniens water extraction, solid-liquid separation concentrates, and gets Os Bovis grunniens water extract (A); Herba Saussureae Involueratae, Radix Lamiophlomidis Rotatae, Herba Taxilli, Flos Carthami, ethanol is reclaimed in alcohol extractions such as Ramulus Cinnamomi, and solid-liquid separation concentrates, and gets alcohol extracts (B) such as Herba Saussureae Involueratae; Os Bovis grunniens water extract (A), alcohol extracts such as Herba Saussureae Involueratae (B) mix, and drying is granulated, and is encapsulated.
The Os Bovis grunniens water extraction can adopt water at low temperature to extract and/or decocting boils.Alcohol extractions such as Herba Saussureae Involueratae can adopt Different concentrations of alcohol merceration and/or hot reflux and/or Soxhlet to extract.Solid-liquid separation can adopt centrifugalize and/or membrance separation and/or filtration.Drying can adopt oven drying and/or vacuum drying and/or lyophilization and/or spray drying.Granulation can be adopted wet granulation and/or dry granulation.
Perhaps adopt the better method that comprises the steps:
Get Ramulus Cinnamomi and extract volatile oil, get Ramulus Cinnamomi Volatile oil (A); Os Bovis grunniens and Ramulus Cinnamomi medicinal residues water extraction, solid-liquid separation concentrates, and gets Os Bovis grunniens and Ramulus Cinnamomi water extract (B); Herba Saussureae Involueratae, Radix Lamiophlomidis Rotatae, Herba Taxilli, ethanol is reclaimed in alcohol extractions such as Flos Carthami, and solid-liquid separation concentrates, and gets alcohol extracts (C) such as Herba Saussureae Involueratae; Alcohol extracts (C) such as Os Bovis grunniens and Ramulus Cinnamomi water extract (B), Herba Saussureae Involueratae mix, drying.Ramulus Cinnamomi Volatile oil (A) mixes with the dry fine powder of alcohol extracts (C) such as Os Bovis grunniens, Ramulus Cinnamomi water extract (B) and Herba Saussureae Involueratae, granulates, and is encapsulated.
Ramulus Cinnamomi Volatile oil extracts and can adopt the volatile oil device to extract and/or steam distillation, organic solvent extraction and/or supercritical CO 2 extraction.The water extraction of Os Bovis grunniens and Ramulus Cinnamomi can adopt water at low temperature to extract and/or decocting boils.Alcohol extractions such as Herba Saussureae Involueratae can adopt Different concentrations of alcohol merceration and/or hot reflux and/or Soxhlet to extract.Solid-liquid separation can adopt centrifugalize and/or membrance separation and/or filtration.Drying can adopt oven drying and/or vacuum drying and/or lyophilization and/or spray drying.Granulation can be adopted wet granulation and/or dry granulation.
The rheumatismal preparation of drug combination method of the treatment of better efficacy is characterized in that comprising the steps:
Get Ramulus Cinnamomi, extract volatile oil, volatile oil wraps up with beta-schardinger dextrin-, gets Ramulus Cinnamomi Volatile oil beta-cyclo dextrin included compound (A); Os Bovis grunniens and Ramulus Cinnamomi, medicinal residues water extraction, solid-liquid separation concentrates, and gets Os Bovis grunniens and Ramulus Cinnamomi water extract (B); Herba Saussureae Involueratae, Radix Lamiophlomidis Rotatae, Herba Taxilli, the Flos Carthami alcohol extraction, solid-liquid separation concentrates, and gets alcohol extracts (C) such as Herba Saussureae Involueratae; Alcohol extracts (C) such as Os Bovis grunniens and Ramulus Cinnamomi water extract (B), Herba Saussureae Involueratae mix, drying.Get dry fine powder.Ramulus Cinnamomi Volatile oil beta-cyclo dextrin included compound (A) mixes with the dry fine powder of alcohol extracts (C) such as Os Bovis grunniens, Ramulus Cinnamomi water extract (B) and Herba Saussureae Involueratae, granulates, and is encapsulated.
In the above-mentioned preparation method, Os Bovis grunniens is the bone of Bovidae (Bovidae) animal yak (Bos grunniens L.).Modern analysis shows that Os Bovis grunniens contains multiple element such as calcium, copper, zinc and osseocolla peptide, polysaccharide etc., and its component content that promotes skeleton development and bone injury healing is than general herbivore skeleton height.The Tibetan medicine is used for the treatment of diseases such as Fengshi Guanjie pain and children's's rickets and muscles and bones flaccidity are soft, osteodynia, meets the theory of Chinese medical science of " removing dampness of dispeling the wind ".
The water extraction of Os Bovis grunniens and Ramulus Cinnamomi can adopt water at low temperature to extract and/or decocting boils.Alcohol extractions such as Herba Saussureae Involueratae can adopt Different concentrations of alcohol merceration and/or hot reflux and/or Soxhlet to extract.Solid-liquid separation can adopt centrifugalize and/or membrance separation and/or filtration.Drying can adopt oven drying and/or vacuum drying and/or lyophilization and/or spray drying.
Utilize the Ramulus Cinnamomi antalgic, be used for the cold in blood amenorrhea, arthralgia.The extraction of volatile oil can adopt the volatile oil device to extract and/or steam distillation, organic solvent extraction and/or supercritical CO 2 extraction.Its volatile oil beta-cyclodextrin inclusion complex (A) is wrapped in molecular microcapsule in the beta-schardinger dextrin-for Ramulus Cinnamomi Volatile oil, is convenient to the raising of the stable and curative effect of preparation.
Alcohol extracts such as Herba Saussureae Involueratae are Herba Saussureae Involueratae, and Radix Lamiophlomidis Rotatae, Herba Taxilli, Flos Carthami etc. be through ethanol extraction, concentrate and get, and the shared removing dampness of dispeling the wind of all medicines, blood circulation and channel invigorating, eliminating stasis to stop pain is used for rheumatic arthritis, rheumatic arthralgia, bones and muscles pain, walking hardship.
Experimental results show that: technical scheme of the present invention is carried out prescription according to theory of Chinese medical science with traditional Tibetan medicine Os Bovis grunniens, Radix Lamiophlomidis Rotatae and Chinese medicine, and by the removing dampness of dispeling the wind, the synergism of aspects such as promoting blood circulation to remove obstruction in the collateral, antalgic is treated rheumatic arthralgia disease effectively.The extraction and separation process of designed system makes the effective site enrichment, has prepared the rheumatismal medicine of effective treatment.
Toxicity and pharmacological evaluation prove:
1. through the safety testing evaluation, do not see tangible toxic reaction after white mice oral (filling stomach) this product, its maximum dosage-feeding is 4 gram crude drugs/per 10 gram body weight, is equivalent to more than 380 times of day for human beings dose; Take pharmaceutical composition 3 months in the technical solution of the present invention continuously for the SD rat, do not find that also this product has tangible toxic reaction, prove that this product do not have obvious toxic and side effects, take safety.
2. give under the right back sufficient plantar aponeurosis of SD rat inject 1% carrageenin respectively, 2.5% formaldehyde 0.1ml makes experimental arthroncus animal model.The pharmaceutical composition of example 4 preparations in the technical solution of the present invention, heavy dose of (2.4g/ml), middle dosage (1.2g/ml), low dose of (0.6g/ml), all oral 10ml/kg administration, compare with carrageenin model control group (0.5%), obvious suppression effect (P＜0.05～0.01) is all arranged, and wherein heavy dose of group reaches 61.3% and 54.6% respectively to the inhibitory rate of intumesce of two kinds of models.Positive control drug ibuprofen tablet (lot number: 20,001 124, Shanghai the 9th pharmaceutical factory produces) the 0.5mg/kg administration, though these two kinds of models are also had the swelling of inhibition effect, but suppression ratio is only up to 36.6%, and the intensity of effect is obviously not as good as the pharmaceutical composition (P＜0.05) in the technical solution of the present invention.In addition the pharmaceutical composition in the technical solution of the present invention also the slow method allergy of white mice skin of pinna to 2, due to the 4-dinitrochlorobenzene obvious suppression effect (P＜(0.01) is arranged, intraperitoneal mouse that pro-inflammatory cytokine is caused and the increase of capillary of skin permeability also have obvious suppression effect (P＜(0.05～0.01), and significant analgesia role (hot tail-flick method of rat and white mice acetic acid twisting method) (P＜(0.05～0.01) is arranged.The removing dampness of dispeling the wind of proof this product, promoting blood circulation to remove obstruction in the collateral, antalgic, the effect of treatment arthromyodynia, and its effect is better than positive control drug.
Utilization modern science evaluation index, functional experiment result through system shows, technical scheme prescription of the present invention does not have obvious toxic and side effects, take safety, this product can make two kinds of experimental arthroncus animal models that obvious suppression swelling effect is arranged, slow method allergy has the obvious suppression effect to the white mice skin of pinna, and intraperitoneal mouse and the increase of capillary of skin permeability that pro-inflammatory cytokine is caused also have the obvious suppression effect, and significant analgesia role is arranged.Therefore this product removing dampness of dispeling the wind, promoting blood circulation to remove obstruction in the collateral, antalgic, the effect of treatment arthromyodynia, and its effect is better than positive control drug.
Example 1:
Get Os Bovis grunniens 40 grams, Herba Saussureae Involueratae 15 grams, Radix Lamiophlomidis Rotatae 15 grams, Herba Taxilli 10 grams, Flos Carthami 10 grams, Ramulus Cinnamomi 10 grams.
Preparation method: each medicinal water extraction of writing out a prescription, concentrate, solid-liquid separation, drying is granulated, and is encapsulated.
Example 2:
Get Os Bovis grunniens 50 grams, Herba Saussureae Involueratae 10 grams, Radix Lamiophlomidis Rotatae 10 grams, Herba Taxilli 10 grams, Flos Carthami 10 grams, Ramulus Cinnamomi 10 grams.
The Os Bovis grunniens water extraction, solid-liquid separation concentrates, and gets Os Bovis grunniens water extract (A);
Herba Saussureae Involueratae, Radix Lamiophlomidis Rotatae, Herba Taxilli, Flos Carthami, Ramulus Cinnamomi is used ethanol extraction, reclaims ethanol, and solid-liquid separation concentrates, and gets alcohol extracts (B) such as Herba Saussureae Involueratae;
Os Bovis grunniens water extract (A), alcohol extracts such as Herba Saussureae Involueratae (B) mix, and drying is granulated, and is encapsulated.
Example 3:
Get Os Bovis grunniens 45 grams, Herba Saussureae Involueratae 15 grams, Radix Lamiophlomidis Rotatae 10 grams, Herba Taxilli 10 grams, Flos Carthami 10 grams, Ramulus Cinnamomi 10 grams.
Ramulus Cinnamomi extracts volatile oil, gets Ramulus Cinnamomi Volatile oil (A);
The medicinal residues water extraction of Os Bovis grunniens and Ramulus Cinnamomi, solid-liquid separation concentrates, and gets Os Bovis grunniens and Ramulus Cinnamomi water extract (B);
Herba Saussureae Involueratae, Radix Lamiophlomidis Rotatae, Herba Taxilli, ethanol is reclaimed in alcohol extractions such as Flos Carthami, and solid-liquid separation concentrates, and gets alcohol extracts (C) such as Herba Saussureae Involueratae;
Alcohol extracts (C) such as Os Bovis grunniens and Ramulus Cinnamomi water extract (B), Herba Saussureae Involueratae mix, drying.
Ramulus Cinnamomi Volatile oil (A) mixes with the dry fine powder of alcohol extracts (C) such as Os Bovis grunniens and Ramulus Cinnamomi water extract (B) and Herba Saussureae Involueratae, granulates, and is encapsulated.
Example 4:
Get Os Bovis grunniens 40 grams, Herba Saussureae Involueratae 10 grams, Radix Lamiophlomidis Rotatae 5 grams, Herba Taxilli 10 grams, Flos Carthami 5, Ramulus Cinnamomi 10 grams.
Ramulus Cinnamomi extracts volatile oil: the Ramulus Cinnamomi vapor distillation, petroleum ether (30-60 ℃) extraction extracts volatile oil, by volatile oil: beta-schardinger dextrin-: water (1: 10: 60) adds volatile oil while stirring in 55 ℃, stirred 1 hour, and put coldly, cold preservation is spent the night, filter, 40 ℃ of dryings of filtering residue get Ramulus Cinnamomi Volatile oil beta-cyclo dextrin included compound (A), place standby
Ramulus Cinnamomi medicinal residues and Os Bovis grunniens decoct with water 3 times, add medical material 10 at every turn and are equipped with water gaging, extract 1 hour, filter, and collecting decoction is concentrated into relative density 1.15 (60 ℃), gets Os Bovis grunniens and Ramulus Cinnamomi water extract (B), and cold preservation is standby;
Herba Saussureae Involueratae, Radix Lamiophlomidis Rotatae, Herba Taxilli, Flos Carthami add 70% alcohol reflux 2 times, add 10 times of amount alcohol of medical material at every turn, extract 1 hour, filter, and merging filtrate, reclaim under reduced pressure concentrates ethanol to relative density 1.15 (60 ℃), gets alcohol extracts (C) such as Herba Saussureae Involueratae;
The extraction extractum that adds Os Bovis grunniens and Ramulus Cinnamomi, spray drying gets the dry fine powder of yellowish-brown, adds the Ramulus Cinnamomi Volatile oil beta-cyclo dextrin included compound, mixing, dry granulation, encapsulated, promptly.
Perhaps use the dry fine powder of alcohol extracts (C) such as the water extract (B) of Ramulus Cinnamomi Volatile oil beta-cyclo dextrin included compound (A) and Os Bovis grunniens, Ramulus Cinnamomi and Herba Saussureae Involueratae to mix, granulate, encapsulated.
[function and notes are controlled] is used for rheumatic arthralgia, bones and muscles pain, walking hardship.
[usage and consumption] is oral, a 1-2 grain, 3 times on the one; Or follow the doctor's advice.
[specification] every dress 0.35g.
Claims (7)
1, the rheumatismal pharmaceutical composition of a kind of treatment is characterized in that mainly being made by following bulk drugs: Os Bovis grunniens 1-60, Herba Saussureae Involueratae 1-20, Radix Lamiophlomidis Rotatae 1-20, Herba Taxilli 1-20, Flos Carthami 1-20, Ramulus Cinnamomi 1-20.
2, according to the rheumatismal pharmaceutical composition of the described treatment of claim 1, wherein the consumption of crude drug is: Os Bovis grunniens 10-45, Herba Saussureae Involueratae 5-12, Radix Lamiophlomidis Rotatae 2-10, Herba Taxilli 5-12, Flos Carthami 5-10, Ramulus Cinnamomi 5-10.
3, according to the rheumatismal pharmaceutical composition of the described treatment of claim 2, wherein the consumption of crude drug is: Os Bovis grunniens 40, Herba Saussureae Involueratae 10, Radix Lamiophlomidis Rotatae 5, Herba Taxilli 10, Flos Carthami 5, Ramulus Cinnamomi 10.
4. according to claim 1-3 treatment medicinal for rheumatism patient compositions preparation method, it is characterized in that comprising the steps: to get Os Bovis grunniens, Herba Saussureae Involueratae, Radix Lamiophlomidis Rotatae, Herba Taxilli, Flos Carthami and Ramulus Cinnamomi, water and/or alcohol extraction, concentrated extracting solution.
5. according to the rheumatismal preparation of pharmaceutical compositions method of claim 4 treatment, it is characterized in that comprising the steps: the Os Bovis grunniens water extraction, the condensed water extract gets the Os Bovis grunniens water extract;
Herba Saussureae Involueratae, Radix Lamiophlomidis Rotatae, Herba Taxilli, Flos Carthami and Ramulus Cinnamomi ethanol extraction concentrate ethanol extract, get alcohol extracts such as Herba Saussureae Involueratae;
The Os Bovis grunniens water extract is mixed with alcohol extracts such as Herba Saussureae Involuerataes.
6. treat rheumatismal preparation of pharmaceutical compositions method according to claim 1-3, it is characterized in that comprising the steps:
Get Ramulus Cinnamomi, extract volatile oil, get Ramulus Cinnamomi Volatile oil;
Os Bovis grunniens and Ramulus Cinnamomi medicinal residues water extraction, the condensed water extracting solution gets Os Bovis grunniens and Ramulus Cinnamomi water extract;
Herba Saussureae Involueratae, Radix Lamiophlomidis Rotatae, Herba Taxilli and Flos Carthami ethanol extraction concentrate ethanol liquid, get alcohol extracts such as Herba Saussureae Involueratae;
Alcohol extracts such as Ramulus Cinnamomi Volatile oil, Os Bovis grunniens and Ramulus Cinnamomi water extract and Herba Saussureae Involueratae mix.
7. according to the rheumatismal preparation of pharmaceutical compositions method of claim 6 treatment, it is characterized in that comprising the steps:
Extract Ramulus Cinnamomi Volatile oil, volatile oil wraps up with beta-schardinger dextrin-, gets the Ramulus Cinnamomi Volatile oil beta-cyclo dextrin included compound;
Os Bovis grunniens and Ramulus Cinnamomi medicinal residues water extraction, the condensed water extract gets Os Bovis grunniens and Ramulus Cinnamomi water extract;
Herba Saussureae Involueratae, Radix Lamiophlomidis Rotatae, Herba Taxilli and Flos Carthami ethanol extraction concentrate ethanol extract, get alcohol extracts such as Herba Saussureae Involueratae;
Ramulus Cinnamomi Volatile oil beta-cyclo dextrin included compound, Os Bovis grunniens and Ramulus Cinnamomi water extract are mixed with alcohol extracts such as Herba Saussureae Involuerataes.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011340614A CN1158093C (en) | 2001-10-19 | 2001-10-19 | Medicine composition containing yak bone for treating rhenmatism and method for making same |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB011340614A CN1158093C (en) | 2001-10-19 | 2001-10-19 | Medicine composition containing yak bone for treating rhenmatism and method for making same |
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| CN1158093C true CN1158093C (en) | 2004-07-21 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP5023253B2 (en) * | 2005-09-14 | 2012-09-12 | 株式会社ノエビア | Composition for preventing and treating fatigue and fatigue |
| CN102727856B (en) * | 2012-07-13 | 2014-04-02 | 安徽安科余良卿药业有限公司 | Volatile oil for treating arthralgia and injuries of tendons and preparation method of volatile oil |
| CN107898889A (en) * | 2017-12-20 | 2018-04-13 | 彭裕民 | Treat Chinese medicine preparation of rheumatism and rheumatoid and preparation method thereof |
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