CN115735784A - Conditional position preference experiment box and method suitable for aerosol exposure - Google Patents
Conditional position preference experiment box and method suitable for aerosol exposure Download PDFInfo
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- CN115735784A CN115735784A CN202211465489.0A CN202211465489A CN115735784A CN 115735784 A CN115735784 A CN 115735784A CN 202211465489 A CN202211465489 A CN 202211465489A CN 115735784 A CN115735784 A CN 115735784A
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- 239000000443 aerosol Substances 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims abstract description 7
- 238000002474 experimental method Methods 0.000 title abstract description 20
- 239000000779 smoke Substances 0.000 claims abstract description 32
- 238000007789 sealing Methods 0.000 claims abstract description 7
- 238000012360 testing method Methods 0.000 claims description 18
- 229910000838 Al alloy Inorganic materials 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 238000005259 measurement Methods 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 12
- 229940079593 drug Drugs 0.000 abstract description 7
- 238000010171 animal model Methods 0.000 abstract description 5
- 238000012549 training Methods 0.000 abstract description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 28
- 238000005192 partition Methods 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000006399 behavior Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 206010012335 Dependence Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/03—Housing for domestic or laboratory animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/02—Breeding vertebrates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L1/00—Enclosures; Chambers
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Abstract
The invention relates to a conditional location preference experiment box and a conditional location preference experiment method suitable for aerosol exposure. A conditional position preference experimental box suitable for aerosol exposure comprises a box body and a transparent cover plate; the baffle plate is vertically arranged in the box body, can slide up and down, and divides the interior of the box body into two independent chambers when the baffle plate slides to the bottom; the transparent cover plate is arranged at the top of the box body and used for sealing the interior of the box body; the side surface of the box body is provided with a plurality of gas path quick connectors which are connected with the smoke exposure machine through the quick connectors; each chamber at least corresponds to one air path quick connector. The invention provides a conditional position preference experiment box and a conditional position preference experiment method suitable for aerosol exposure, which have a smoke exposure function and realize smoke exposure of experimental animals in a drug matching training stage in a conditional position preference experiment.
Description
Technical Field
The invention relates to a conditional location preference test box and a conditional location preference test method suitable for aerosol exposure.
Background
The scientific fields of neurobiology, pharmacology, toxicology and the like often apply position preference experiments to evaluate the mental dependence of drugs. The position preference experiment analyzes and contrasts the activity condition of a mouse between a drug matching region and a non-drug matching region after observing experimental animals (rats and mice) and performing matching training, and obtains the evaluation of the degree of dependence on drugs. At present, no conditional place preference test box can complete the smoke exposure test.
Disclosure of Invention
In order to solve the problems in the background art, the invention provides a conditional position preference experiment box and a conditional position preference experiment method suitable for aerosol exposure, which have a smoke exposure function and realize smoke exposure of experimental animals in a drug matching training stage in a conditional position preference experiment.
The technical scheme for solving the problems is as follows: a conditional position preference experimental box suitable for aerosol exposure is characterized in that:
comprises a box body and a transparent cover plate;
the baffle plate is vertically arranged in the box body, can slide up and down, and divides the interior of the box body into two independent chambers when the baffle plate slides to the bottom; the transparent cover plate is arranged at the top of the box body and used for sealing the interior of the box body;
the side surface of the box body is provided with a plurality of gas path quick connectors which are connected with the smoke exposure machine through the quick connectors; each cavity at least corresponds to one gas circuit quick connector.
Furthermore, two partition walls are symmetrically arranged inside the box body, a gap exists between the two partition walls, the baffle is arranged between the gaps, grooves are formed in two sides of the baffle, and the two grooves are respectively matched with the two partition walls to be sealed.
Furthermore, two air path quick connectors are arranged on the front side and the rear side of the box body.
Furthermore, the lower part of each chamber is provided with a grid plate, and a storage chamber is arranged below the grid plate; the grid plate is detachably connected with the chamber.
Furthermore, an excrement storage box is arranged in the storage chamber, and the excrement storage box is detachably connected with the cavity.
Furthermore, a drawer for storing excrement is arranged in the storage chamber, and the drawer can be drawn out from the side face of the box body.
Furthermore, the box body is made of a high-quality aluminum alloy frame and an acrylic material, and is firm and durable.
Furthermore, the transparent cover plate is also provided with an illuminating lamp for illuminating the interior of the box body.
Further, the conditional position preference experimental box further comprises a camera, and the camera records the video inside the chamber through the transparent cover plate.
In addition, the invention also provides an experimental method of the conditional position preference experimental box suitable for aerosol exposure, which is characterized by comprising the following steps:
1) Baseline measurement phase
Taking down the transparent cover plate, removing the baffle plate to communicate the two chambers, putting the mouse into the box body, allowing the mouse to move freely, and placing a camera above the box body for recording for 15 minutes;
2) Phase of establishing conditions
Inserting the baffle into the box body, putting the mouse into the box body on one side in the morning, giving smoke for a preset time such as 1 hour or 2 hours, and putting the mouse back into the cage after finishing the smoke; after 4 hours, the mice are placed in the box body on the other side, air is introduced, and the duration time is consistent with the morning; after 5-8 days, the experimental mice establish the association of the smoke and the context of the box body;
3) Testing phase
Removing the baffle plate to communicate the two chambers, putting the mouse into the box body, allowing the mouse to move freely, and placing a camera above the box body for recording videos for 15 minutes; if the laboratory mouse has a preference for smoke, the mouse will stay more on the side of the housing associated with the smoke; and vice versa.
The invention has the advantages that:
1) The experimental box for realizing conditional position preference can be used for carrying out smoke exposure experiments and evaluating addiction behaviors of cigarettes, and can be exposed in the box body, so that the matching time of transferring the medicine into the box body after administration is saved, and the experimental efficiency is greatly improved;
2) The baffle can prevent smoke from moving between the two box bodies; the cover plate can prevent smoke leakage and isolate the pollution of external gas to experimental animals in the box body, and the cover plate is a transparent cover plate and can observe the behavior of a mouse under the condition of sealing the box body;
3) The side opening of the experimental box is provided with the air path quick connection interface, and the atomized medicine is filled in the experimental box through the connection with the smoke exposure machine, so that the parameters such as the concentration of atomized medicine administration are dynamically adjusted.
Drawings
FIG. 1 is a block diagram of an embodiment of a conditional position preference test box suitable for aerosol exposure.
Wherein: 1. the gas path quick connector comprises a box body, 2, a transparent cover plate, 3, a baffle, 4, a gas path quick connector, 5, a partition wall, 6, a grid plate, 7 and a drawer.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings of the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention.
Referring to fig. 1, a conditional site preference test box suitable for aerosol exposure includes a box body 1 and a transparent cover plate 2.
The transparent cover plate 2 is placed on the top of the box body 1 and used for sealing the interior of the box body 1. The box body 1 is internally provided with a baffle 3 which is vertically arranged, the baffle 3 can slide up and down, and when the baffle 3 slides to the bottom, the interior of the box body 1 is divided into two independent and closed chambers; when the baffle 3 is removed, the two separate chambers are in communication. The side surface of the box body 1 is provided with a plurality of gas path quick connectors 4, and the gas path quick connectors 4 are connected with a smoke exposure machine; each cavity at least corresponds to one air path quick connector 4 and can be connected with a smoke exposure machine to dynamically adjust the concentration and other parameters of atomized medicine. The conditional position preference experiment box has a smoke exposure function, and smoke exposure of experimental animals in a drug matching training stage in a conditional position preference experiment is achieved.
As a preferred embodiment of the present invention, two partition walls 5 are arranged inside the box 1, the two partition walls 5 are symmetrically arranged, a gap exists between the two partition walls 5, the baffle 3 is arranged between the gap, two sides of the baffle 3 are provided with grooves, and the two grooves are respectively matched with the two partition walls 5 for sealing. The both sides of baffle 3 are equipped with the recess and form the sealed of space left and right sides with two cooperation of separating the shelves wall 5, and the bottom of baffle 3 and the sealed of 1 bottom contact formation space bottom of box, and the top of baffle 3 and the bottom surface contact of transparent cover 2 form the sealed to the space top, finally realize dividing into two independent, confined cavities with 1 inside of box.
As a preferred embodiment of the present invention, referring to fig. 1, two air path quick connectors 4 are respectively disposed on the front and rear sides of the box body 1, that is, one air path quick connector 4 is disposed on each of the front and rear sides of each chamber, and each air path quick connector 4 can be connected to different smoke exposure machines to dynamically adjust parameters such as concentration of atomized medicine.
As a preferred embodiment of the present invention, referring to fig. 1, a grid plate 6 is provided at the lower part of each chamber, and a storage chamber is provided below the grid plate 6; the grid plate 6 is detachably connected with the chamber.
Specifically, a step is provided on the wall surface inside the box body 1, and the step contacts with the edge of the grid plate 6 and carries the grid plate 6. The mouse is placed on the grid plate 6, and the excrement falls into the storage chamber from the holes on the grid plate 6, so that the mouse is kept clean, and the influence of the excrement discharged on the experimental result is avoided. The grid plate 6 can be removed from the upper part of the chamber for cleaning.
As a preferred embodiment of the present invention, a feces storage box is arranged in the storage chamber, which is not shown in the figure, and the feces storage box is detachably connected with the chamber. The excrement case receives the mouse excrement that drops from grid plate 6, after the experiment, can take out grid plate 6, takes out the excrement case again and clears up it.
As a preferred embodiment of the invention, referring to FIG. 1, a drawer 7 for storing excrement is arranged in the storage chamber, and the drawer 7 can be drawn out from the side of the case 1, so that the excrement of the mouse can be cleaned more conveniently.
As a preferred embodiment of the invention, the 1 is made of a high-quality aluminum alloy frame and an acrylic material, and is firm and durable.
As a preferred embodiment of the present invention, the cover plate 2 is further provided with an illuminating lamp for illuminating the inside of the box body 1, and further comprises a camera for recording video inside the chamber through the transparent cover plate 2.
Examples
Referring to fig. 1, a conditional position preference experiment box suitable for aerosol exposure comprises a box body 1 and a transparent cover plate 2. The transparent cover plate 2 is placed on the top of the box body 1 and used for sealing the interior of the box body 1.
The box body 1 is internally provided with a baffle 3 which is vertically arranged, the baffle 3 can slide up and down, and when the baffle 3 slides to the bottom, the interior of the box body 1 is divided into two independent and closed chambers; when the baffle 3 is removed, the two separate chambers are in communication. Two inside shelves walls 5 that separate of box 1, two are separated the setting of shelves wall 5 symmetry, and have the space between two shelves walls 5, baffle 3 sets up between the space, the both sides of baffle 3 are equipped with the recess, and two recesses are sealed with two cooperation of separating shelves wall 5 respectively. The both sides of baffle 3 are equipped with the recess and form the sealed of space left and right sides with two cooperation of separating the shelves wall 5, and the bottom of baffle 3 and the sealed of 1 bottom contact formation space bottom of box, and the top of baffle 3 and the bottom surface contact of transparent cover 2 form the sealed to the space top. The quick connector 4 of two gas circuits is all equipped with in both sides around the box 1, and both sides all are equipped with a quick connector 4 of gas circuit around every cavity promptly, and the quick connector 4 of every gas circuit can connect different smog and expose the machine, the concentration isoparametric of dynamic adjustment atomizing dosing.
The wall surface in the box body 1 is provided with steps which are contacted with the edge of the grid plate 6 and bear the grid plate 6. The mouse is placed on the grid plate 6, and the excrement of the mouse falls into the storage chamber from the holes on the grid plate 6, so that the mouse is kept clean, and the influence of excrement discharged on the experimental result is avoided. The grid plate 6 can be removed from the upper part of the chamber for cleaning. Be equipped with the drawer 7 of depositing the excrement in the locker room, drawer 7 can be taken out from box 1 side, and it is more convenient to clear up mouse excrement.
Still be equipped with the light on the apron 2 for provide the illumination to box 1 inside, still include the camera, the camera sees through transparent cover 2 and records a video to the cavity inside.
When the aerosol exposure conditional position preference experiment box is used for carrying out an aerosol exposure experiment, the method comprises the following steps:
1 base line measurement phase
Taking down the transparent cover plate 2, removing the baffle plate 3 to communicate the two chambers, putting the mouse into the box body 1 to allow the mouse to move freely, and placing a camera above the box body 1 to record a video for 15 minutes;
2 phase of establishing conditions
Inserting the baffle 3 into the box body 1, putting the mouse into the box body 1 on one side in the morning, giving smoke for a preset time such as 1 hour or 2 hours, and putting the mouse back into the cage after finishing the smoke; after 4 hours, the mouse is placed in the box body 1 on the other side, and air is introduced, wherein the duration time is consistent with the morning; after 5 days, the experimental mouse establishes the association between the smoke and the context environment of the box body 1;
3 testing phase
Removing the baffle 3 to communicate the two chambers, putting the mouse into the box body 1 to allow the mouse to move freely, and placing a camera above the box body 1 for recording for 15 minutes; if the laboratory mouse has a preference for smoke, the mouse will stay more on the side of the housing 1 associated with the smoke; and vice versa.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and those skilled in the art can still make modifications to the technical solutions described in the above embodiments, or make equivalent substitutions for some technical features. Therefore, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (10)
1. A conditional positional preference test box adapted for aerosol exposure, comprising:
comprises a box body (1) and a transparent cover plate (2);
the box body (1) is internally provided with a baffle (3) which is vertically arranged, the baffle (3) can slide up and down, and when the baffle (3) slides to the bottom, the interior of the box body (1) is divided into two independent chambers; the transparent cover plate (2) is placed at the top of the box body (1) and used for sealing the interior of the box body (1);
the side surface of the box body (1) is provided with a plurality of gas path quick connectors (4), and the gas path quick connectors (4) are connected with a smoke exposure machine; each chamber at least corresponds to one air path quick connector (4).
2. A conditional position preference test box for aerosol exposure according to claim 1, wherein:
two inside separating wall (5) of box (1), two separate wall (5) symmetry settings, and have the space between two separating wall (5), baffle (3) set up between the space, the both sides of baffle (3) are equipped with the recess, and two recesses are sealed with two separating wall (5) cooperations respectively.
3. A conditional position preference test box for aerosol exposure according to claim 2, wherein:
two air path quick connectors (4) are arranged on the front side and the rear side of the box body (1).
4. A conditional position preference test box for aerosol exposure according to claim 3, wherein:
the lower part of each chamber is provided with a grid plate (6), and a storage chamber is arranged below the grid plate (6); the grid plate (6) is detachably connected with the chamber.
5. A conditional position preference test box for aerosol exposure according to claim 4, wherein:
be equipped with the excrement case in the locker room, the excrement case is connected for dismantling with the cavity.
6. A conditional position preference test box for aerosol exposure according to claim 4, wherein:
a drawer (7) for storing excrement is arranged in the storage chamber, and the drawer (7) can be drawn out from the side face of the box body (1).
7. A conditional position preference test kit for aerosol exposure according to claim 1, wherein:
the frame (1) is made of a high-quality aluminum alloy frame and an acrylic material.
8. A conditional position preference test kit for aerosol exposure according to claim 1, wherein:
and the cover plate (2) is also provided with an illuminating lamp for illuminating the inside of the box body (1).
9. A conditional position preference test kit for aerosol exposure according to claim 1, wherein:
still include the camera, the camera sees through transparent cover plate (2) and records a video to the cavity inside.
10. A method of using an aerosol exposure conditional location preference test kit, comprising the steps of:
1) Baseline measurement phase
Taking down the transparent cover plate (2), removing the baffle plate (3), communicating the two chambers, putting the mouse into the box body (1), allowing the mouse to move freely, and placing a camera above the box body (1) for recording;
2) Phase of establishing condition
Inserting the baffle (3) into the box body (1), putting the mouse into the box body (1) on one side in the morning, giving smoke for a preset time such as 1 hour or 2 hours, and putting the mouse back into the cage after the smoke is given; after 4 hours, the mouse is placed in the box body (1) at the other side, and air is introduced, wherein the duration time is consistent with the morning; after 5 to 8 days, the experimental mouse establishes the association between the smoke and the context of the box body (1);
3) Testing phase
Removing the baffle (3) to communicate the two chambers, putting the mouse into the box body (1) to allow the mouse to move freely, and placing a camera above the box body (1) for recording a video; if the experimental mouse has a preference for smoke, the mouse will stay more on the side of the box (1) associated with the smoke; and vice versa.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211465489.0A CN115735784A (en) | 2022-11-22 | 2022-11-22 | Conditional position preference experiment box and method suitable for aerosol exposure |
| PCT/CN2023/133458 WO2024109852A1 (en) | 2022-11-22 | 2023-11-22 | Conditioned place preference experiment box and method suitable for aerosol exposure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211465489.0A CN115735784A (en) | 2022-11-22 | 2022-11-22 | Conditional position preference experiment box and method suitable for aerosol exposure |
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| Publication Number | Publication Date |
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| CN115735784A true CN115735784A (en) | 2023-03-07 |
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| CN202211465489.0A Pending CN115735784A (en) | 2022-11-22 | 2022-11-22 | Conditional position preference experiment box and method suitable for aerosol exposure |
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| CN (1) | CN115735784A (en) |
| WO (1) | WO2024109852A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116420629A (en) * | 2023-03-16 | 2023-07-14 | 浙江大学 | Multifunctional animal exposure experimental device |
| WO2024109852A1 (en) * | 2022-11-22 | 2024-05-30 | 中国科学院深圳先进技术研究院 | Conditioned place preference experiment box and method suitable for aerosol exposure |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6644244B2 (en) * | 2001-12-05 | 2003-11-11 | University Of Florida | Apparatus and methods for testing pain sensitivity |
| CN208891418U (en) * | 2018-09-11 | 2019-05-24 | 山西医科大学 | It is a kind of for measuring the experimental box of rats and mice conditioned place preference |
| CN113243304B (en) * | 2021-06-24 | 2022-10-28 | 中国科学院深圳先进技术研究院 | Marmoset behaviourology experiment box |
| CN216456393U (en) * | 2021-07-02 | 2022-05-10 | 国家烟草质量监督检验中心 | Animal inhalation type administration condition position preference training equipment |
| CN114514881B (en) * | 2021-12-16 | 2023-04-21 | 中国科学院深圳先进技术研究院 | Experimental equipment |
| CN115735784A (en) * | 2022-11-22 | 2023-03-07 | 中国科学院深圳先进技术研究院 | Conditional position preference experiment box and method suitable for aerosol exposure |
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2022
- 2022-11-22 CN CN202211465489.0A patent/CN115735784A/en active Pending
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2023
- 2023-11-22 WO PCT/CN2023/133458 patent/WO2024109852A1/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024109852A1 (en) * | 2022-11-22 | 2024-05-30 | 中国科学院深圳先进技术研究院 | Conditioned place preference experiment box and method suitable for aerosol exposure |
| CN116420629A (en) * | 2023-03-16 | 2023-07-14 | 浙江大学 | Multifunctional animal exposure experimental device |
| CN116420629B (en) * | 2023-03-16 | 2024-02-02 | 浙江大学 | Multifunctional animal exposure experimental device |
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| Publication number | Publication date |
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| WO2024109852A1 (en) | 2024-05-30 |
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