CN115645481A - Ointment for quickly curing abscess and wound - Google Patents
Ointment for quickly curing abscess and wound Download PDFInfo
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- CN115645481A CN115645481A CN202211439488.9A CN202211439488A CN115645481A CN 115645481 A CN115645481 A CN 115645481A CN 202211439488 A CN202211439488 A CN 202211439488A CN 115645481 A CN115645481 A CN 115645481A
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Abstract
The invention discloses a paste for quickly curing wound abscess. The paste comprises the following components in parts by weight: 30-60 parts of astragalus extract, 10-20 parts of sophora flavescens extract, 10-20 parts of garden burnet extract, 5-15 parts of angelica extract, 20-40 parts of yam rhizome extract, 20-40 parts of pine bark extract, 10-20 parts of borneol and 500-700 parts of vaseline. The paste disclosed by the invention can reduce the expression level of PTEN genes in vivo and quickly cure abscess of wounds and sores, and the yam rhizome extract and the lycopodium clavatum extract in the components are combined for use, so that the synergy is realized, and the effect is better.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine paste, and particularly relates to a paste for quickly curing abscess and wound.
Background
The chronic hard-to-heal wound surface on the body surface is also called body surface ulcer, which is caused by various reasons, still does not heal after more than 1 month of treatment and has no obvious healing tendency, and mainly comprises diabetic ulcer, traumatic ulcer, pressure sore, arteriovenous ulcer, cancerous ulcer, infectious ulcer and the like. Among them, traumatic ulcers (sores) often produce abscesses, making treatment more difficult.
The traditional Chinese medicine is adopted to treat the abscess of the wound and the ulcer, and comprises the steps of tonifying qi and blood, removing necrosis and promoting granulation, warming and tonifying methods, tonifying deficiency and removing stasis, and clearing heat and removing toxicity, but the methods are all the treatment methods of one side and have no universality. The skin regeneration treatment technology (wet treatment technology) comprises MEBO wet burn ointment (ME BO) and wet exposure therapy (MEBT), which is abbreviated as MEBT/MEBO. The MEBT/MEBO is one of the traditional Chinese medicine external treatment methods, is widely applied to the treatment of chronic wounds which are difficult to heal in recent years, and the curative effect of the MEBT/MEBO is accepted by medical workers, but the method is complex to operate, can be operated by special doctors, and has high treatment cost for the common wound abscess.
Wound healing is an extremely complex biological process involving a variety of cells, proteins and factors. This process comprises three main stages: inflammation, proliferation and remodeling are accomplished by the interaction of cells, proteins, factors, etc. through various pathways. But when any one of the links is wrong or blocked, the healing of the wound surface can be delayed. Researches show that the expression level of PTEN in granulation tissue of the wound surface is a remarkable marker for wound surface healing, when the skin is wounded and the wound surface is formed, the expression level of PTEN changes, and an organism can down-regulate the expression level of PTEN to promote the wound surface healing. When a normal wound is interfered to form a chronic wound, the regulation capability of an organism on PTEN is reduced, so that the expression of PTEN cannot be reduced in time, and the wound is healed slowly. The traditional Chinese medicine composition capable of obviously reducing the expression level of PTEN is developed, and is very effective in eliminating abscess and wound.
Disclosure of Invention
The invention aims to provide a paste for quickly curing wound abscess.
The ointment for quickly curing the abscess of the wound and the ulcer consists of the following components in parts by weight: 30-60 parts of astragalus extract, 10-20 parts of sophora flavescens extract, 10-20 parts of garden burnet extract, 5-15 parts of angelica dahurica extract, 20-40 parts of yam rhizome extract, 20-40 parts of pine bark extract, 10-20 parts of borneol and 500-700 parts of vaseline.
The preparation method of the astragalus extract comprises the following steps: pulverizing dried radix astragali, sieving with 60-100 mesh sieve, percolating with 10-15 times of 75% ethanol for 1-3 hr, adding 4-8 times of 75% ethanol into the residue, percolating for 0.5-1.5 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure below 50 deg.C, and concentrating to obtain extract with a medicinal liquid ratio of 1 (1.0-1.2).
The preparation method of the sophora flavescens extract comprises the following steps: pulverizing dried radix Sophorae Flavescentis, sieving with 60-100 mesh sieve, percolating with 10-15 times of 70% ethanol for 1-3 hr, adding 5-10 times of 70% ethanol into the residue, further percolating for 1-2 hr, discarding the residue, mixing the two extractive solutions, recovering ethanol under reduced pressure below 50 deg.C, and concentrating to obtain extract with a liquid-to-liquid ratio of 1 (1.0-1.3).
The preparation method of the sanguisorba extract comprises the following steps: drying herba Hedyotidis Diffusae in the sun, pulverizing, sieving with 60-120 mesh sieve, percolating with 10-15 times of 75% ethanol for 1-3 hr, adding 2-6 times of 75% ethanol into the residue, further percolating for 1-3 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C, and concentrating to obtain extract with a liquid-to-liquid ratio of 1 (1.0-1.2).
The preparation method of the angelica dahurica extract comprises the following steps: pulverizing dried radix Angelicae Dahuricae, sieving with 60-80 mesh sieve, percolating with 10-16 times of 70% ethanol for 1-3 hr, adding 5-10 times of 70% ethanol into the residue, further percolating for 1-2 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure below 50 deg.C, and concentrating to obtain extract with a liquid-to-liquid ratio of 1 (1.0-1.3).
The preparation method of the yam rhizome extract comprises the following steps: pulverizing dried rhizoma Dioscoreae Septemlobae, sieving with 50-80 mesh sieve, percolating with 8-16 times of 75% ethanol for 1-3 hr, adding 5-10 times of 75% ethanol into the residue, further percolating for 1-3 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure below 50 deg.C, and concentrating to obtain extract with a liquid-to-liquid ratio of 1 (1.0-1.3).
The preparation method of the Pinus sylvestris extract comprises the following steps: grinding dried fir pine tree into powder, sieving with 50-100 mesh sieve, adding 5-10 times of water, soaking for 15-25 hr, centrifuging at 4000-6000rpm, collecting supernatant, and evaporating to dryness at low temperature under reduced pressure.
A preparation method of an ointment for quickly curing abscess and wound comprises the following steps: adding 500-700 parts of vaseline into a clean pot according to parts by weight, and heating to 45-55 ℃ until the vaseline is completely melted; adding radix astragali extract 30-60 parts, radix Sophorae Flavescentis extract 10-20 parts, radix Sangusorbae extract 10-20 parts, radix Angelicae Dahuricae extract 5-15 parts, rhizoma Dioscoreae Septemlobae extract 20-40 parts, and Pinus sylvestris extract 20-40 parts, heating to 60-70 deg.C, and stirring; cooling to 45-55 deg.C, adding ground Borneolum 10-20 parts, and stirring.
The invention has the beneficial effects that: the paste disclosed by the invention can reduce the expression level of PTEN genes in vivo and quickly cure abscess of wounds and sores, and the yam rhizome extract and the lycopodium clavatum extract in the components are combined for use, so that the synergy is realized, and the effect is better.
Detailed Description
In order that the invention may be more fully understood, reference will now be made to the following more detailed description. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Example 1
The ointment for quickly curing the abscess of the wound and the ulcer consists of the following components in parts by weight: 50 parts of astragalus extract, 15 parts of sophora flavescens extract, 15 parts of garden burnet extract, 10 parts of angelica extract, 30 parts of yam rhizome extract, 30 parts of pine bark extract, 15 parts of borneol and 600 parts of vaseline.
The preparation method of the astragalus extract comprises the following steps: pulverizing dried radix astragali, sieving with 80 mesh sieve, percolating with 12 times of 75% ethanol for 2 hr, adding 6 times of 75% ethanol into the residue, percolating for 1 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a liquid-to-liquid ratio of 1.1.
The preparation method of the sophora flavescens extract comprises the following steps: pulverizing dried radix Sophorae Flavescentis, sieving with 80 mesh sieve, percolating with 12 times of 70% ethanol for 2 hr, adding 8 times of 70% ethanol into the residue, percolating for 1.5 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a ratio of 1.1.
The preparation method of the sanguisorba extract comprises the following steps: sun drying herba Hedyotidis Diffusae, pulverizing, sieving with 100 mesh sieve, percolating with 12 times of 75% ethanol for 2 hr, adding 4 times of 75% ethanol into the residue, percolating for 2 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a ratio of 1.1.
The preparation method of the angelica dahurica extract comprises the following steps: pulverizing dried radix Angelicae Dahuricae, sieving with 70 mesh sieve, percolating with 13 times of 70% ethanol for 2 hr, adding 8 times of 70% ethanol into the residue, percolating for 1.5 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a ratio of 1.1.
The preparation method of the yam rhizome extract comprises the following steps: pulverizing dried rhizoma Dioscoreae Septemlobae, sieving with 70 mesh sieve, percolating with 12 times of 75% ethanol for 2 hr, adding 8 times of 75% ethanol into the residue, percolating for 2 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a liquid-liquid ratio of 1.2.
The preparation method of the Pinus sylvestris extract comprises the following steps: grinding dried fir pine tree into powder, sieving with 80 mesh sieve, adding 8 times of water, soaking for 20 hr, centrifuging at 5000rpm, collecting supernatant, and evaporating to dryness under reduced pressure at low temperature.
A preparation method of an ointment for quickly curing abscess on a wound comprises the following steps: adding 600 parts by weight of vaseline into a clean pot, and heating to 50 ℃ until the vaseline is completely melted; adding radix astragali extract 50 parts, radix Sophorae Flavescentis extract 15 parts, radix Sangusorbae extract 15 parts, radix Angelicae Dahuricae extract 10 parts, rhizoma Dioscoreae Septemlobae extract 30 parts, and Pinus sylvestris extract 30 parts, heating to 65 deg.C, and stirring; cooling to 50 deg.C, adding ground Borneolum 15 parts, and stirring.
Example 2
The ointment for quickly curing the abscess of the wound and the ulcer consists of the following components in parts by weight: 30 parts of astragalus extract, 10 parts of sophora flavescens extract, 10 parts of garden burnet extract, 6 parts of angelica dahurica extract, 20 parts of yam rhizome extract, 20 parts of pinus sylvestris extract, 10 parts of borneol and 500 parts of vaseline.
The preparation method of the astragalus extract comprises the following steps: pulverizing dried radix astragali, sieving with 60 mesh sieve, percolating with 10 times of 75% ethanol for 1 hr, adding 4 times of 75% ethanol into the residue, percolating for 0.5 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a ratio of 1.
The preparation method of the sophora flavescens extract comprises the following steps: pulverizing dried radix Sophorae Flavescentis, sieving with 60 mesh sieve, percolating with 10 times of 70% ethanol for 1 hr, adding 5 times of 70% ethanol into the residue, percolating for 1 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a ratio of 1.
The preparation method of the garden burnet extract comprises the following steps: sun-drying herba Hedyotidis Diffusae, pulverizing, sieving with 60 mesh sieve, percolating with 10 times of 75% ethanol for 1 hr, adding 2 times of 75% ethanol into the residue, further percolating and extracting for 1 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a ratio of 1.
The preparation method of the angelica dahurica extract comprises the following steps: pulverizing dried radix Angelicae Dahuricae, sieving with 60 mesh sieve, percolating with 10 times of 70% ethanol for 1 hr, adding 5 times of 70% ethanol into the residue, percolating for 1 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a ratio of 1.
The preparation method of the yam rhizome extract comprises the following steps: pulverizing dried rhizoma Dioscoreae Septemlobae, sieving with 50 mesh sieve, percolating with 8 times of 75% ethanol for 1 hr, adding 5 times of 75% ethanol into the residue, percolating for 1 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a liquid-liquid ratio of 1.
The preparation method of the Pinus sylvestris extract comprises the following steps: grinding dried fir pine tree into powder, sieving with 50 mesh sieve, adding 5 times of water, soaking for 15 hr, centrifuging at 4000rpm, collecting supernatant, and evaporating to dryness under reduced pressure at low temperature.
A preparation method of an ointment for quickly curing abscess on a wound comprises the following steps: adding 500 parts by weight of vaseline into a clean pot, and heating to 45 ℃ until the vaseline is completely melted; adding radix astragali extract 30 parts, radix Sophorae Flavescentis extract 10 parts, radix Sangusorbae extract 10 parts, radix Angelicae Dahuricae extract 6 parts, rhizoma Dioscoreae Septemlobae extract 20 parts, and Pinus sylvestris extract 20 parts, heating to 60 deg.C, and stirring; cooling to 4 deg.C, adding ground Borneolum Syntheticum 10 parts, and stirring.
Example 3
The ointment for quickly curing the abscess of the wound and the ulcer consists of the following components in parts by weight: 60 parts of astragalus extract, 20 parts of sophora flavescens extract, 20 parts of garden burnet extract, 15 parts of angelica extract, 40 parts of yam rhizome extract, 40 parts of pinus sylvestris extract, 20 parts of borneol and 700 parts of vaseline.
The preparation method of the astragalus extract comprises the following steps: pulverizing dried radix astragali, sieving with 100 mesh sieve, percolating with 15 times of 75% ethanol for 3 hr, adding 8 times of 75% ethanol into the residue, percolating for 1.5 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a ratio of 1.2.
The preparation method of the sophora flavescens extract comprises the following steps: taking dried radix Sophorae Flavescentis, pulverizing, sieving with 100 mesh sieve, percolating with 15 times of 70% ethanol for 3 hr, adding 10 times of 70% ethanol into the residue, further percolating and extracting for 2 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a liquid-medicine ratio of 1.3.
The preparation method of the sanguisorba extract comprises the following steps: sun drying herba Hedyotidis Diffusae, pulverizing, sieving with 120 mesh sieve, percolating with 15 times of 75% ethanol for 3 hr, adding 6 times of 75% ethanol into the residue, percolating for 3 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a ratio of 1.2.
The preparation method of the angelica dahurica extract comprises the following steps: pulverizing dried radix Angelicae Dahuricae, sieving with 80 mesh sieve, percolating with 16 times of 70% ethanol for 3 hr, adding 10 times of 70% ethanol into the residue, percolating for 2 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a ratio of 1.3.
The preparation method of the yam rhizome extract comprises the following steps: pulverizing dried rhizoma Dioscoreae Septemlobae, sieving with 80 mesh sieve, percolating with 16 times of 75% ethanol for 3 hr, adding 10 times of 75% ethanol into the residue, percolating for 3 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a liquid-liquid ratio of 1.3.
The preparation method of the Pinus sylvestris extract comprises the following steps: grinding dried fir pine tree into powder, sieving with 100 mesh sieve, adding 10 times of water, soaking for 25 hr, centrifuging at 6000rpm, collecting supernatant, and evaporating to dryness under reduced pressure at low temperature.
A preparation method of an ointment for quickly curing abscess and wound comprises the following steps: adding 700 parts by weight of vaseline into a clean pot, and heating to 55 ℃ until the vaseline is completely melted; adding radix astragali extract 60 parts, radix Sophorae Flavescentis extract 20 parts, radix Sangusorbae extract 20 parts, radix Angelicae Dahuricae extract 15 parts, rhizoma Dioscoreae Septemlobae extract 40 parts, and Pinus sylvestris extract 40 parts, heating to 70 deg.C, and stirring; cooling to 55 deg.C, adding 20 parts of ground Borneolum Syntheticum, and stirring.
Comparative example 1
The ointment for quickly curing the abscess of the wound and the ulcer consists of the following components in parts by weight: 50 parts of astragalus extract, 15 parts of sophora flavescens extract, 15 parts of garden burnet extract, 10 parts of angelica extract, 60 parts of yam rhizome extract, 15 parts of borneol and 600 parts of vaseline.
The preparation method of the astragalus extract comprises the following steps: pulverizing dried radix astragali, sieving with 80 mesh sieve, percolating with 12 times of 75% ethanol for 2 hr, adding 6 times of 75% ethanol into the residue, percolating for 1 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a liquid-to-liquid ratio of 1.1.
The preparation method of the sophora flavescens extract comprises the following steps: pulverizing dried radix Sophorae Flavescentis, sieving with 80 mesh sieve, percolating with 12 times of 70% ethanol for 2 hr, adding 8 times of 70% ethanol into the residue, percolating for 1.5 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a ratio of 1.1.
The preparation method of the sanguisorba extract comprises the following steps: sun drying herba Hedyotidis Diffusae, pulverizing, sieving with 100 mesh sieve, percolating with 12 times of 75% ethanol for 2 hr, adding 4 times of 75% ethanol into the residue, percolating for 2 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a ratio of 1.1.
The preparation method of the angelica dahurica extract comprises the following steps: pulverizing dried radix Angelicae Dahuricae, sieving with 70 mesh sieve, percolating with 13 times of 70% ethanol for 2 hr, adding 8 times of 70% ethanol into the residue, percolating for 1.5 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a ratio of 1.1.
The preparation method of the yam rhizome extract comprises the following steps: pulverizing dried rhizoma Dioscoreae Septemlobae, sieving with 70 mesh sieve, percolating with 12 times of 75% ethanol for 2 hr, adding 8 times of 75% ethanol into the residue, percolating for 2 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a liquid-liquid ratio of 1.2.
A preparation method of an ointment for quickly curing abscess on a wound comprises the following steps: adding 600 parts by weight of vaseline into a clean pot, and heating to 50 ℃ until the vaseline is completely melted; adding 50 parts of astragalus extract, 15 parts of sophora flavescens extract, 15 parts of garden burnet extract, 10 parts of angelica dahurica extract and 60 parts of yam rhizome extract, heating to 65 ℃, and uniformly stirring; cooling to 50 deg.C, adding ground Borneolum 15 parts, and stirring.
Comparative example 2
The ointment for quickly curing the abscess of the wound and the ulcer consists of the following components in parts by weight: 50 parts of astragalus extract, 15 parts of sophora flavescens extract, 15 parts of garden burnet extract, 10 parts of angelica extract, 60 parts of pine bark extract, 15 parts of borneol and 600 parts of vaseline.
The preparation method of the astragalus extract comprises the following steps: pulverizing dried radix astragali, sieving with 80 mesh sieve, percolating with 12 times of 75% ethanol for 2 hr, adding 6 times of 75% ethanol into the residue, percolating for 1 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a liquid-to-liquid ratio of 1.1.
The preparation method of the sophora flavescens extract comprises the following steps: taking dried radix Sophorae Flavescentis, pulverizing, sieving with 80 mesh sieve, percolating with 12 times of 70% ethanol for 2 hr, adding 8 times of 70% ethanol into the residue, further percolating and extracting for 1.5 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a ratio of the medicinal liquid to the medicinal liquid of 1.1.
The preparation method of the sanguisorba extract comprises the following steps: sun drying herba Hedyotidis Diffusae, pulverizing, sieving with 100 mesh sieve, percolating with 12 times of 75% ethanol for 2 hr, adding 4 times of 75% ethanol into the residue, percolating for 2 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a ratio of 1.1.
The preparation method of the angelica dahurica extract comprises the following steps: pulverizing dried radix Angelicae Dahuricae, sieving with 70 mesh sieve, percolating with 13 times of 70% ethanol for 2 hr, adding 8 times of 70% ethanol into the residue, percolating for 1.5 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure at 50 deg.C below, and concentrating to obtain extract with a ratio of 1.1.
The preparation method of the Pinus sylvestris extract comprises the following steps: grinding dried fir pine tree into powder, sieving with 80 mesh sieve, adding 8 times of water, soaking for 20 hr, centrifuging at 5000rpm, collecting supernatant, and evaporating to dryness under reduced pressure at low temperature.
A preparation method of an ointment for quickly curing abscess on a wound comprises the following steps: adding 600 parts by weight of vaseline into a clean pot, and heating to 50 ℃ until the vaseline is completely melted; adding radix astragali extract 50 parts, radix Sophorae Flavescentis extract 15 parts, radix Sangusorbae extract 15 parts, radix Angelicae Dahuricae extract 10 parts, and Pinus sylvestris extract 60 parts, heating to 65 deg.C, and stirring; cooling to 50 deg.C, adding ground Borneolum 15 parts, and stirring.
Experimental example:
taking healthy adult SPF-grade Wistar male rats, 12-14 weeks old and about 220g of body weight, and establishing a chronic wound model difficult to heal:
anesthesia: 7% chloral hydrate is used for carrying out intraperitoneal injection and anesthesia on rats according to the dose of 0.5ml/100 g;
preparing skin: preparing skin at the position of lumbar vertebrae at two sides of the spinal column of a rat, and marking the area to be molded at the skin preparation position by a stamp with the diameter of 1.5cm after skin preparation;
making an wound: marking an open wound surface reaching the fascia at the skin preparation position, and paying attention to sterile operation in the process;
medicine injection: after the wound is created, a rat needing to establish a chronic wound model difficult to heal is modeled according to the dose of 6mg hydrocortisone acetate injected per 100g to establish the rat chronic wound model difficult to heal;
scab tearing: after the model is made, all the rats with wound are subjected to scab tearing before dressing change every time so as to delay wound healing.
After the model building of each group of rats is completed, the rats are immediately subjected to drug intervention and are randomly divided into 8 groups according to a random number table method, and 10 rats in each group are obtained. Before dressing change, the wound is debrided by 1/5000 furacilin solution, dressing change is carried out 3 times a day, and the grouping conditions are as follows:
blank control group: the skin is prepared at the same position without any injurious treatment, two layers of normal saline gauze are covered at the skin preparation position, double layers of sterilized dry gauze are covered, and then the gauze is fixed without other intervening treatment.
Model group: and performing full-layer skin excision at the modeling part according to the model building method, and injecting hydrocortisone to build a rat chronic wound model difficult to heal. Covering double-layer normal saline gauze on the wound surface, then covering double-layer sterilized dry gauze, and fixing the gauze.
Beifuji group: performing full-layer skin excision at the modeling part according to the model building method, injecting hydrocortisone to build a rat chronic difficult-to-heal wound model, and externally applying double-layer Beifuji soaked gauze (70U/cm) on the wound 2 ) Then, double-layer sterilized dry gauze is covered, and then the gauze is fixed.
Examples 1-3 and comparative examples 1-3 groups: and performing full-thickness skin excision at the modeling part according to the model building method, and injecting hydrocortisone to build a rat chronic wound surface model difficult to heal. Ointment (0.5 g/cm) prepared in examples 1 to 3 and comparative examples 1 to 3 was applied to the outside of the wound 2 ) Then, double-layer sterilized dry gauze is covered, and then the gauze is fixed.
The drug administration was started immediately after the molding was completed, and 5 patients were sacrificed at random in each group by means of neck-broken sacrifice after 7% chloral hydrate over-anesthesia at 2 time points of day 5 and day 8, respectively. The operation is finished under the aseptic condition, the whole granulation tissue which is about 2mm away from the wound edge is cut, PTEN detection primers are arranged, RT-PCR detection is carried out, and the determination result is shown in tables 1-2:
TABLE 1
Note: * Represents P <0.05 compared to the example 1 group.
TABLE 2
Note: * Represents P <0.05 compared to the example 1 group.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that various changes and modifications can be made by those skilled in the art without departing from the spirit of the invention, and these changes and modifications are all within the scope of the invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (8)
1. The ointment for quickly curing the abscess on the wound is characterized by comprising the following components in parts by weight: 30-60 parts of astragalus extract, 10-20 parts of sophora flavescens extract, 10-20 parts of garden burnet extract, 5-15 parts of angelica extract, 20-40 parts of yam rhizome extract, 20-40 parts of pine bark extract, 10-20 parts of borneol and 500-700 parts of vaseline.
2. The ointment for rapidly curing abscess of wound according to claim 1, wherein the astragalus extract is prepared by the following steps: pulverizing dried radix astragali, sieving with 60-100 mesh sieve, percolating with 10-15 times of 75% ethanol for 1-3 hr, adding 4-8 times of 75% ethanol into the residue, percolating for 0.5-1.5 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure below 50 deg.C, and concentrating to obtain extract with a medicinal liquid ratio of 1 (1.0-1.2).
3. The ointment for rapidly curing abscess of wound according to claim 1, wherein said Sophorae radix extract is prepared by the steps of: pulverizing dried radix Sophorae Flavescentis, sieving with 60-100 mesh sieve, percolating with 10-15 times of 70% ethanol for 1-3 hr, adding 5-10 times of 70% ethanol into the residue, further percolating for 1-2 hr, discarding the residue, mixing the two extractive solutions, recovering ethanol under reduced pressure below 50 deg.C, and concentrating to obtain extract with a liquid-to-liquid ratio of 1 (1.0-1.3).
4. The ointment for rapidly curing abscess of wound according to claim 1, wherein the sanguisorba officinalis extract is prepared by the following steps: drying herba Hedyotidis Diffusae in the sun, pulverizing, sieving with 60-120 mesh sieve, percolating with 10-15 times of 75% ethanol for 1-3 hr, adding 2-6 times of 75% ethanol into the residue, further percolating for 1-3 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure below 50 deg.C, and concentrating to obtain extract with a liquid-to-liquid ratio of 1 (1.0-1.2).
5. The ointment for rapidly curing abscess of wound according to claim 1, wherein the radix angelicae extract is prepared by the following steps: pulverizing dried radix Angelicae Dahuricae, sieving with 60-80 mesh sieve, percolating with 10-16 times of 70% ethanol for 1-3 hr, adding 5-10 times of 70% ethanol into the residue, further percolating for 1-2 hr, discarding the residue, mixing the two extractive solutions, recovering ethanol under reduced pressure below 50 deg.C, and concentrating to obtain extract with a liquid-to-liquid ratio of 1 (1.0-1.3).
6. The ointment for rapidly curing wound abscess according to claim 1, wherein the yam rhizome extract is prepared by the following steps: pulverizing dried rhizoma Dioscoreae Septemlobae, sieving with 50-80 mesh sieve, percolating with 8-16 times of 75% ethanol for 1-3 hr, adding 5-10 times of 75% ethanol into the residue, further percolating for 1-3 hr, discarding residue, mixing the two extractive solutions, recovering ethanol under reduced pressure below 50 deg.C, and concentrating to obtain extract with a liquid-to-liquid ratio of 1 (1.0-1.3).
7. The ointment for rapidly curing abscess of wound according to claim 1, wherein said Pinus sylvestris extract is prepared by the following steps: grinding dried fir pine tree into powder, sieving with 50-100 mesh sieve, adding 5-10 times of water, soaking for 15-25 hr, centrifuging at 4000-6000rpm, collecting supernatant, and evaporating to dryness at low temperature under reduced pressure.
8. The method for preparing an ointment for rapidly curing abscess of wound according to claim 1, which comprises the following steps: adding 500-700 parts of vaseline into a clean pot according to parts by weight, and heating to 45-55 ℃ until the vaseline is completely melted; adding radix astragali extract 30-60 parts, radix Sophorae Flavescentis extract 10-20 parts, radix Sangusorbae extract 10-20 parts, radix Angelicae Dahuricae extract 5-15 parts, rhizoma Dioscoreae Septemlobae extract 20-40 parts, and Pinus sylvestris extract 20-40 parts, heating to 60-70 deg.C, and stirring; cooling to 45-55 deg.C, adding ground Borneolum 10-20 parts, and stirring.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211439488.9A CN115645481A (en) | 2022-11-17 | 2022-11-17 | Ointment for quickly curing abscess and wound |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101284067A (en) * | 2008-04-23 | 2008-10-15 | 孙玉伙 | Chinese medicine wash-out effervescent tablet for disinfection and anti-inflammation of the wound surface and preparation method thereof |
| CN102631423A (en) * | 2012-05-09 | 2012-08-15 | 白玲强 | Care solution for wound cleaning |
| CN103800759A (en) * | 2014-03-14 | 2014-05-21 | 张利民 | Traditional Chinese medicine for treating middle-aged rheumatism and rheumatoid |
-
2022
- 2022-11-17 CN CN202211439488.9A patent/CN115645481A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101284067A (en) * | 2008-04-23 | 2008-10-15 | 孙玉伙 | Chinese medicine wash-out effervescent tablet for disinfection and anti-inflammation of the wound surface and preparation method thereof |
| CN102631423A (en) * | 2012-05-09 | 2012-08-15 | 白玲强 | Care solution for wound cleaning |
| CN103800759A (en) * | 2014-03-14 | 2014-05-21 | 张利民 | Traditional Chinese medicine for treating middle-aged rheumatism and rheumatoid |
Non-Patent Citations (3)
| Title |
|---|
| 常乐政等: "地黄醇液治疗外伤性创面360例", 中国中医急症, vol. 6, no. 05, pages 205 * |
| 阳辉顺等: "肛窦切开挂线合薢黄洗剂熏洗坐浴治疗***30例", 湖南中医杂志, vol. 36, no. 2, pages 10 - 12 * |
| 高文武等: "生肌散治疗创口不愈95例小结", 四川中医, vol. 21, no. 08, pages 73 - 74 * |
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