CN115624585B - 一种治疗或预防风湿性关节炎的中药组合物和中药制剂 - Google Patents
一种治疗或预防风湿性关节炎的中药组合物和中药制剂 Download PDFInfo
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Abstract
本发明公开了一种治疗或预防风湿性关节炎的中药组合物和中药制剂,该中药组合物包括以下重量份的组分:当归10‑40份、乌药10‑30份、羌活10‑30份、独活10‑30份、青皮10‑30份、白芷10‑30份、威灵仙10‑30份、肉桂10‑30份、八角茴香10‑30份、防风10‑20份、木通10‑20份、枳壳10‑20份、红花10‑20份和甘草5‑15份。该中药组合物可有效解决现有的西药存在的无法从根本上治疗风湿性关节炎的问题。
Description
技术领域
本发明涉及中药制剂技术领域,具体涉及一种治疗或预防风湿性关节炎的中药组合物和中药制剂。
背景技术
风湿性关节炎属***反应性疾病,是风湿热的主要表现之一,多以急性发热及关节疼痛起病,典型表现是轻度或中度发热,游走性多关节炎,受累关节多为膝,踝、肩、肘,腕等大关节,常见由一个关节转移至另一个关节,病变局部呈现红,肿、灼热、剧痛,部分病人也有几个关节同时发病,不典型的病人仅有关节疼痛而无其他炎症表现,急性炎症一般于2-4周消退,不留后遗症,但常反复发作。若风湿活动影响心脏,则可发生心肌炎,甚至遗留心脏瓣膜病变。
风湿性关节炎治疗时,西医多以阿司匹林、扶他林、萘普生或其他非激素类抗炎药等药物进行治疗,但是西药大多只能起到止痛的作用,无法从根本上实现治疗风湿性关节炎的目的。
发明内容
针对现有技术中的上述不足,本发明提供了一种治疗或预防风湿性关节炎的中药组合物和中药制剂,该中药组合物可有效解决现有的西药存在的无法从根本上治疗风湿性关节炎的问题。
为实现上述目的,本发明解决其技术问题所采用的技术方案是:
一种治疗或预防风湿性关节炎的中药组合物,包括以下重量份的组分:当归10-40份、乌药10-30份、羌活10-30份、独活10-30份、青皮10-30份、白芷10-30份、威灵仙10-30份、肉桂10-30份、八角茴香10-30份、防风10-20份、木通10-20份、枳壳10-20份、红花10-20份和甘草5-15份。
进一步地,包括以下重量份的组分:当归25-35份、乌药20-30份、羌活15-25份、独活15-25份、青皮15-25份、白芷15-25份、威灵仙15-25份、肉桂15-25份、八角茴香15-25份、防风13-18份、木通13-18份、枳壳13-18份、红花13-18份和甘草8-12份。
进一步地,包括以下重量份的组分:当归30份、乌药25份、羌活20份、独活20份、青皮20份、白芷20份、威灵仙20份、肉桂20份、八角茴香20份、防风15份、木通15份、枳壳15份、红花15份和甘草10份。
一种治疗或预防风湿性关节炎的中药制剂,采用上述的中药组合物制备而成。
进一步地,中药制剂为外用制剂。
进一步地,外用制剂为贴膏、擦剂或喷剂。
进一步地,外用制剂的制备方法为:将上述中药材放入砂锅中用冷水浸泡,液面淹过饮片约2cm为宜,浸泡30min后,用武火迅速煮沸,改用文火维持15~20min左右,趁热滤取药汁后,再重新加水煎煮2次,最后将3次煎煮所得药液混合,然后与辅料再混合即可制得外用制剂。
本发明所产生的有益效果为:
方中当归甘、辛而性温,善走血分,一方面擅长于活血通经止痛,在风湿痹痛、跌扑损伤、痈疽疮疡等方面具有较好的作用,另一方面还擅长于补血润燥,可使血脉充盈而更好祛除痹阻的邪气、润养陈久之损伤;乌药有顺气散寒止痛功效,当归与乌药配伍,治痹从气血入手,以活血行气、通脉止痛为主,以温养益血为辅,祛邪治标与养血扶正兼顾,共作方中君药。臣以羌活、独活、青皮,羌独二活通理一身风寒湿痹,发挥祛风除湿、蠲痹止痛之效;青皮破气行滞,一者使气行湿化血运、痹通痛止,一者助乌药行气散结、消肿止痛。又佐以白芷散寒祛风止痛,燥湿消肿排脓;佐以威灵仙祛风除湿,舒筋活络;佐以肉桂、八角茴香散寒止痛,温通经脉;佐以防风祛风胜湿;佐以木通通络兼利水消肿;佐以枳壳增强行气止痛;佐以红花活血化瘀,消肿止痛。诸佐药配合,既有增强君臣药疗伤痛痹止痛之意,又能缓解痹阻及伤痛所致之肿痛、麻木、筋骨拘挛等症状不适。使以甘草调和诸药,协同药力;方中香药众多,所含芳香成分在外用制剂中亦可发挥促进透皮之效,亦可视作方中引经使药。
全方诸药配伍,以活血行气止痛为主立法,意能通利治标快速缓解伤痛及痹阻疼痛;辅以祛风除湿、行气散结之药,又能治病求因,消除引致疼痛之本。标本兼治,风湿性关节炎具有较好的治疗效果;同时,由于该药具有活血行气止痛的作用,对于跌扑日久失治之陈旧伤痛以及风湿痹阻所致之关节不利、腰腿酸痛、麻木等也具有缓解和治疗作用。
具体实施方式
实施例1
一种治疗或预防风湿性关节炎的中药组合物,包括以下重量份的组分:当归20份、乌药30份、羌活15份、独活20份、青皮20份、白芷15份、威灵仙15份、肉桂15份、八角茴香20份、防风15份、木通15份、枳壳20份、红花10份和甘草5份。
采用上述中药组合物制备外用制剂的方法为:将上述中药材放入砂锅中用冷水浸泡,液面淹过饮片约2cm为宜,浸泡30min后,用武火迅速煮沸,改用文火维持20min左右,趁热滤取药汁后,再重新加水煎煮2次,最后将3次煎煮所得药液混合,然后与辅料制成贴膏。
实施例2
一种治疗或预防风湿性关节炎的中药组合物,包括以下重量份的组分:当归40份、乌药20份、羌活20份、独活30份、青皮10份、白芷20份、威灵仙20份、肉桂15份、八角茴香15份、防风20份、木通15份、枳壳15份、红花20份和甘草10份。
其制备方法同实施例1。
实施例3
一种治疗或预防风湿性关节炎的中药组合物,包括以下重量份的组分:当归30份、乌药25份、羌活17份、独活16份、青皮18份、白芷22份、威灵仙25份、肉桂25份、八角茴香17份、防风17份、木通18份、枳壳13份、红花15份和甘草12份。
其制备方法同实施例1。
实施例4
一种治疗或预防风湿性关节炎的中药组合物,包括以下重量份的组分:当归30份、乌药25份、羌活20份、独活20份、青皮20份、白芷20份、威灵仙20份、肉桂20份、八角茴香20份、防风15份、木通15份、枳壳15份、红花15份和甘草10份。
其制备方法同实施例1。
对比例1
一种治疗或预防风湿性关节炎的中药组合物,包括以下重量份的组分:丹参30份、乌药25份、羌活20份、独活20份、青皮20份、白芷20份、威灵仙20份、肉桂20份、八角茴香20份、防风15份、木通15份、枳壳15份、红花15份和甘草10份。
其制备方法同实施例1。
对比例2
一种治疗或预防风湿性关节炎的中药组合物,包括以下重量份的组分:当归30份、乌药25份、羌活20份、独活20份、枳实20份、白芷20份、威灵仙20份、肉桂20份、八角茴香20份、防风15份、木通15份、枳壳15份、红花15份和甘草10份。
其制备方法同实施例1。
对比例3
一种治疗或预防风湿性关节炎的中药组合物,包括以下重量份的组分:当归30份、乌药25份、羌活20份、独活20份、青皮20份、白芷20份、威灵仙20份、肉桂20份、八角茴香20份、防风15份、木通15份、枳壳15份、赤芍15份和甘草10份。
其制备方法同实施例1。
对比例4
一种治疗或预防风湿性关节炎的中药组合物,包括以下重量份的组分:当归30份、乌药25份、羌活20份、独活20份、青皮20份、白芷20份、海桐皮20份、肉桂20份、八角茴香20份、防风15份、木通15份、枳壳15份、红花15份和甘草10份。
其制备方法同实施例1。
对比例5
一种治疗或预防风湿性关节炎的中药组合物,包括以下重量份的组分:当归30份、乌药25份、羌活20份、独活20份、青皮20份、白芷20份、威灵仙20份、良姜20份、八角茴香20份、防风15份、木通15份、枳壳15份、红花15份和甘草10份。
其制备方法同实施例1。
对比例6
一种治疗或预防风湿性关节炎的中药组合物,包括以下重量份的组分:当归8份、乌药8份、羌活35份、独活35份、青皮30份、白芷20份、威灵仙35份、肉桂20份、八角茴香20份、防风15份、木通15份、枳壳15份、红花15份和甘草10份。
其制备方法同实施例1。
试验例
1、临床资料
1.1、收集临床2020-2022年确诊患有风湿性关节炎且处于发作期的患者,共计200人,年龄在30-50岁之间,平均年龄43.5岁,将上述患者随机分成10组,每组20人,每组患者之间具有可比性,分别为每组患者使用实施例1-4和对比例1-6中的贴膏,每日一次,使用后观察患者的疼痛情况,连续使用4天,分别记录患者的治疗情况,具体结果见表1。
1.2、治疗标准
有效:患者疼痛程度减轻;
无效:患者疼痛程度无明显变化;
治愈:患者疼痛程度完全消失;
有效率=(有效人数+治愈人数)/总人数*100%
1.3、治疗结果
表1:治疗情况统计
通过上表中的数据可以看出,实施例1-4中的中药制剂对于风湿性关节炎的治疗效果明显优于对比例1-6中中药组合物的治疗效果,患者使用实施例1-4中的中药制剂后症状得到明显的缓解,随着使用时间的增加,患者的症状减轻更加明显,连续使用4天后,大部分患者的症状完全消失。
将对比例1与实施例4中的中药组合物进行对比,采用作用相似的丹参替换了当归,通过对比例1中的治疗效果可以看出,替换后的组合物的治疗效果明显变差,可以推断,替换后的组合物内君药发生改变,导致药物的主要治疗原则发生变化,且各个药材之间的相互作用减弱或消失,导致治疗效果变差。
将对比例2与实施例4中的中药组合物进行对比,采用作用相似的枳实替换青皮,通过对比例2中的治疗效果可以看出,替换后的组合物的治疗效果明显变差,可以推断,枳实与乌药等药物之间的协同作用消失,导致治疗效果变差。
将对比例3与实施例4中的中药组合物进行对比,采用作用相似的赤芍替换了红花,通过对比例3中的治疗效果可以看出,替换后的组合物的治疗效果变差,可以推断红花与其余药物之间存在相互作用关系,替换后,相互作用关系消失。
将对比例4与实施例4中的中药组合物进行对比,采用作用相似的海桐皮替换了威灵仙,通过对比例4中的治疗效果可以看出,替换后的组合物的治疗效果变差,可以推断威灵仙与其余药物之间存在相互作用关系,替换后,相互作用关系消失。
将对比例5与实施例4中的中药组合物进行对比,采用作用相似的良姜替换了肉桂,通过对比例5中的治疗效果可以看出,替换后的组合物的治疗效果变差,可以推断肉桂与其余药物之间存在相互作用关系,替换后,相互作用关系消失。
将对比例6与实施例4中的中药组合物进行对比,改变了组方中药物的用量,相当于调整了组合物内的君臣佐使关系,通过对比例6中的治疗效果可以看出,改变用量配比后的中药组合物的治疗效果变差,证明组合物内药物的用量对于治疗也是至关重要的。
综上分析得知,本申请的中药组合物的药材之间存在相互作用关系,组合物作为一个整体发挥治疗作用,当药材发生改变后,会导致组合物整体治疗效果发生改变。而且,本申请中的中药组合物对于跌打损伤造成的关节疼痛也具有一定的治疗效果。
Claims (6)
1.一种治疗或预防风湿性关节炎的中药组合物,其特征在于,由以下重量份的组分组成:当归10-40份、乌药10-30份、羌活10-30份、独活10-30份、青皮10-30份、白芷10-30份、威灵仙10-30份、肉桂10-30份、八角茴香10-30份、防风10-20份、木通10-20份、枳壳10-20份、红花10-20份和甘草5-15份。
2.如权利要求1所述的治疗或预防风湿性关节炎的中药组合物,其特征在于,由以下重量份的组分组成:当归25-35份、乌药20-30份、羌活15-25份、独活15-25份、青皮15-25份、白芷15-25份、威灵仙15-25份、肉桂15-25份、八角茴香15-25份、防风13-18份、木通13-18份、枳壳13-18份、红花13-18份和甘草8-12份。
3.如权利要求1所述的治疗或预防风湿性关节炎的中药组合物,其特征在于,由以下重量份的组分组成:当归30份、乌药25份、羌活20份、独活20份、青皮20份、白芷20份、威灵仙20份、肉桂20份、八角茴香20份、防风15份、木通15份、枳壳15份、红花15份和甘草10份。
4.一种治疗或预防风湿性关节炎的中药制剂,其特征在于,采用权利要求1-3中任一项所述的中药组合物制备而成。
5.如权利要求4中所述的治疗或预防风湿性关节炎的中药制剂,其特征在于,所述中药制剂为外用制剂。
6.如权利要求5中所述的治疗或预防风湿性关节炎的中药制剂,其特征在于,所述外用制剂为贴膏、擦剂或喷剂。
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