CN115569674A - Ion exchange chromatographic column capable of being rapidly mounted and dismounted - Google Patents
Ion exchange chromatographic column capable of being rapidly mounted and dismounted Download PDFInfo
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- CN115569674A CN115569674A CN202211203228.1A CN202211203228A CN115569674A CN 115569674 A CN115569674 A CN 115569674A CN 202211203228 A CN202211203228 A CN 202211203228A CN 115569674 A CN115569674 A CN 115569674A
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- column
- ion exchange
- column tube
- exchange chromatography
- filter element
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/02—Column or bed processes
- B01J47/022—Column or bed processes characterised by the construction of the column or container
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- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The invention belongs to the technical field of chromatographic columns, and discloses an ion exchange chromatographic column capable of being quickly mounted and dismounted, which comprises a liquid retaining groove, a column tube and a connecting assembly, wherein a first internal thread is arranged at the lower end of the liquid retaining groove, a first external thread is arranged at the upper end of the column tube, a second external thread is arranged at the lower end of the column tube, a second internal thread is arranged at the upper end of the connecting assembly, a filter element is arranged in the connecting assembly, the upper end of the column tube and the lower end of the liquid retaining groove are mutually matched and connected through the first external thread and the first internal thread, and the lower end of the column tube and the upper end of the connecting assembly are mutually matched and connected through the second internal thread and the second external thread. The invention can realize the purposes of convenient disassembly and free assembly; the volume of the liquid retention groove, the volume of the column tube and the specification of the filter element are adjusted, so that the effects of adjusting components with different specifications according to the sample requirement at any time and improving the working efficiency are achieved; the filter element can be replaced at any time, and the filter element is not easy to fall off.
Description
Technical Field
The invention belongs to the technical field of chromatographic columns, and particularly relates to an ion exchange chromatographic column capable of being quickly mounted and dismounted.
Background
In recent years, ion exchange chromatography is widely applied with the advantages of high analysis speed, high sensitivity, environmental friendliness, good selectivity, small sample introduction volume, low maintenance cost, long service life and the like. Ion chromatography is based on the principle of ion exchange and utilizes the difference in ion exchange capacity of different ions to be detected relative to the stationary phase to achieve separation. Where separation is central, the key to ion exchange chromatography technology is the chromatography column.
The prior ion exchange chromatographic column comprises a column tube, a liquid retention groove, a filter element, a joint and other structures, when different samples are separated, different sample loading volumes, leacheate volumes, leaching rates and the like are involved, the filter element with fixed length, volume and fixed specification cannot meet the requirements, the chromatographic column which meets the characteristics of the samples needs to be redesigned, and the working efficiency is reduced.
In addition, in the existing ion exchange chromatographic column, a plurality of filter elements are directly embedded on the column and cannot be replaced according to the particle size and the service time of a sample, and the filter elements are prevented from falling off by a plunger piston under part of the chromatographic column, but certain falling risk still exists.
Disclosure of Invention
In view of the above-mentioned shortcomings of the prior art, it is an object of the present invention to provide an ion exchange chromatography column that can be quickly installed and removed.
In order to achieve the purpose, the invention adopts the following technical scheme:
the utility model provides an ion exchange chromatographic column that can install fast and dismantle, stays groove, pillar pipe and coupling assembling including liquid, the lower extreme that the groove was stayed to liquid is provided with first internal thread, the upper end of pillar pipe is provided with first external screw thread, and the lower extreme of pillar pipe is provided with the second external screw thread, coupling assembling's upper end is provided with the second internal thread, the inside filter core that is provided with of coupling assembling, the upper end of pillar pipe and the lower extreme that the groove was stayed to liquid are connected through first external screw thread and first internal thread mutually supporting, the lower extreme of pillar pipe and coupling assembling's upper end are connected through second internal thread and second external screw thread mutually supporting.
In some preferred embodiments of the present invention, the insertion openings are formed in both the top and bottom of the vial.
Preferably, the liquid retention groove is connected with an insertion opening at the top of the column tube through a thread and extends to the sample inlet, and a sealing gasket is arranged at the thread connection position.
Preferably, the connecting assembly is in threaded connection with an insertion opening at the bottom of the column tube and extends to the liquid outlet, and a sealing gasket is arranged at the threaded connection position.
Preferably, the column tube can be set to different volumes through the adjustment of the inner diameter and the length, and is connected with the liquid retaining groove and the connecting assembly through the matching of the external thread and the internal thread.
Preferably, the liquid retention tank can be selected to have different volumes as required.
Preferably, the volume of the liquid retention tank is 5ml, 15ml, 20ml or 30ml.
Preferably, the filter element can select different specifications and pore sizes as required, and the flow rate is controlled by adjusting the specifications and the pore sizes.
Preferably, the inside of the lower extreme of coupling assembling is inlayed and is had annular shock insulator, the internal diameter of annular shock insulator is less than the internal diameter of filter core, the filter core is placed in annular shock insulator top.
Compared with the prior art, the invention has the following beneficial effects:
(1) According to the ion exchange chromatographic column capable of being rapidly assembled and disassembled, the liquid in the ion exchange chromatographic column is retained among the groove, the column pipe and the connecting assembly through the internal and external threaded interfaces, so that the purposes of convenient disassembly and free assembly are achieved, the components can be freely replaced, and the effects of convenience and rapidness in operation are improved;
(2) The volume of the liquid retention groove, the volume of the column tube and the specification of the filter element are adjusted, and the components with different specifications are adjusted at any time according to the requirement of a sample through free disassembly and assembly, so that the effect of improving the working efficiency is achieved;
(3) Through set up annular spacer in coupling assembling to reach the renew cartridge at any time, and the difficult effect that drops of filter core.
Drawings
Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:
FIG. 1 is a schematic diagram of a rapidly attachable and detachable ion exchange chromatography column.
In the figure: 1-a liquid flow groove, 2-a first internal thread, 3-a column pipe, 4-a first external thread, 5-a second external thread, 6-a connecting component, 7-a second internal thread, 8-an annular spacer, 9-a sealing gasket and 10-a filter element.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications can be made by persons skilled in the art without departing from the spirit of the invention. All falling within the scope of the present invention.
Example 1
As shown in fig. 1, a fast-to-install and-remove ion exchange chromatography column according to an embodiment of the present invention includes:
the liquid retention tank 1 is provided with a first internal thread 2 at the lower end of the liquid retention tank 1;
the upper end of the column tube 3 is provided with a first external thread 4, the upper end of the column tube 3 and the lower end of the liquid retaining groove 1 are mutually matched and connected through the first external thread 4 and the first internal thread 2, and the lower end of the column tube 3 is provided with a second external thread 5;
The ion exchange chromatographic column provided by the embodiment of the invention has a simple structure, can be freely assembled, and realizes the effects of quick assembly and disassembly, thereby improving the working efficiency.
And sealing gaskets 9 are arranged at the top and the bottom of the column tube 3, and the tightness is ensured by the sealing gaskets 9. And insertion openings are formed in the top and the bottom of the column tube 3.
The column tube 3 can be set to different volumes, including different internal diameters and lengths, and is connected with the liquid retaining groove 1 and the connecting assembly 6 through the matching of external threads and internal threads.
The liquid retention groove 1 penetrates through an insertion opening at the top of the column tube 3 and the sealing gasket 9 and extends to the sample inlet.
The volume of the liquid retention tank 1 is 5ml, 15ml, 20ml or 30ml.
The connecting assembly 6 penetrates through an insertion opening and a sealing washer 9 at the bottom of the column tube 3 and extends to a liquid outlet.
The filter element 10 can be set to different specifications and different pore sizes, and the flow rate can be controlled by different specifications and different pore sizes.
In a preferred embodiment of the present invention, an annular spacer 8 is embedded inside the lower end of the connecting assembly 6, the inner diameter of the annular spacer 8 is smaller than the inner diameter of the filter element 10, and the filter element 10 is placed above the annular spacer 8 to prevent the filter element 10 from falling off. The annular spacer can be fixed inside the lower end of the connecting component 6 by gluing or directly cutting and cutting in the customization for reservation. When the filter element needs to be replaced, the filter element is taken out from the upper part.
The invention can install and dismantle the ion exchange chromatographic column rapidly, the upper end of the column tube 3 and the lower end of the liquid retention tank 1 are connected with each other through the first external thread 4 and the first internal thread 2; the filter element 10 is embedded in the connecting assembly 6; the upper end of coupling assembling 6 is passed through second internal thread 7 and the 5 mutually supporting connections of second external screw thread with the lower extreme of column tube 3 to the effect that ion exchange chromatographic column can be installed fast and dismantle is realized.
Example 2
The volume of the liquid retention groove 1 is set to be 5ml, and the liquid retention groove is connected with the column tube 3 through the matching of the external thread and the internal thread;
the length and the inner diameter of the column tube 3 are respectively set to be 250mm and 6.4mm, and the column tube is connected with the liquid retention tank 1 and the connecting component 6 through the matching of external threads and internal threads;
the flow rate is controlled by setting the pore size of the filter element 10 to 2 μm.
Example 3
The volume of the liquid retention groove 1 is set to be 15ml, and the liquid retention groove is connected with the column tube 3 through the matching of the external thread and the internal thread;
the length and the inner diameter of the column tube 3 are respectively set to be 260mm and 6.8mm, and the column tube is connected with the liquid retention tank 1 and the connecting component 6 through the matching of external threads and internal threads;
the flow rate was controlled by setting the pore size of the filter element 10 to 3 μm.
Example 4
The volume of the liquid retention tank 1 is set to be 20ml, and the liquid retention tank is connected with the column tube 3 through the matching of external threads and internal threads;
the length and the inner diameter of the column tube 3 are respectively set to be 250mm and 6.4mm, and the column tube is connected with the liquid retention tank 1 and the connecting component 6 through the matching of external threads and internal threads;
the flow rate is controlled by setting the pore size of the filter element 10 to 4 μm.
The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes and modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention.
Claims (9)
1. The utility model provides an ion exchange chromatographic column that can install fast and dismantle, its characterized in that stays groove, column pipe and coupling assembling including liquid, the lower extreme that the groove was stayed to liquid is provided with first internal thread, the upper end of column pipe is provided with first external screw thread, and the lower extreme of column pipe is provided with the second external screw thread, coupling assembling's upper end is provided with the second internal thread, the inside filter core that is provided with of coupling assembling, the lower extreme that the groove was stayed to the upper end of column pipe and liquid is connected through first external screw thread and first internal thread mutually supporting, the lower extreme of column pipe is connected through second internal thread and second external screw thread mutually supporting with coupling assembling's upper end.
2. The rapidly installable and removable ion exchange chromatography column of claim 1 wherein the top and bottom of the column tube have insertion openings formed therein.
3. The rapidly installable and removable ion exchange chromatography column of claim 2, wherein the fluid retention groove is threadably engaged with the insertion port at the top of the column tube and extends to the sample inlet, and wherein the threaded engagement is provided with a sealing gasket.
4. A rapid-fit and disassemble ion exchange chromatography column as claimed in claim 2, wherein said connecting assembly is screwed into the insertion opening at the bottom of the column tube and extends to the liquid outlet, and a sealing gasket is provided at the screwed connection.
5. The rapidly installable and removable ion exchange chromatography column of claim 1 wherein said column tube is configured to be of different volume by adjustment of internal diameter and length, and is connected to the fluid retention groove and the connection assembly by mating external and internal threads.
6. The rapidly installable and removable ion exchange chromatography column of claim 1 wherein said retention tank is capable of being selected from different volumes as desired.
7. The rapidly installable and removable ion exchange chromatography column of claim 6, wherein the volume of said liquid retention tank is 5ml, 15ml, 20ml or 30ml.
8. The rapidly installable and removable ion exchange chromatography column of claim 1, wherein the filter element is capable of selecting different sizes and pore sizes as desired, and the flow rate is controlled by adjusting the sizes and pore sizes.
9. The rapidly installable and removable ion exchange chromatography column of claim 1 wherein the lower end of the connector assembly has an annular spacer embedded therein, the annular spacer having an inner diameter less than an inner diameter of the filter element, the filter element being positioned over the annular spacer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211203228.1A CN115569674A (en) | 2022-09-29 | 2022-09-29 | Ion exchange chromatographic column capable of being rapidly mounted and dismounted |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211203228.1A CN115569674A (en) | 2022-09-29 | 2022-09-29 | Ion exchange chromatographic column capable of being rapidly mounted and dismounted |
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| Publication Number | Publication Date |
|---|---|
| CN115569674A true CN115569674A (en) | 2023-01-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211203228.1A Pending CN115569674A (en) | 2022-09-29 | 2022-09-29 | Ion exchange chromatographic column capable of being rapidly mounted and dismounted |
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Citations (17)
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| EP0328146A2 (en) * | 1988-02-12 | 1989-08-16 | The Perkin-Elmer Corporation | A high pressure column assembly for a liquid chromatograph system |
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| CN103386228A (en) * | 2012-05-11 | 2013-11-13 | 苏州市金翔钛设备有限公司 | Fixing apparatus for preventing filter core from dropping |
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| CN108999672A (en) * | 2018-08-15 | 2018-12-14 | 江西绿擎过滤材料有限公司 | Filter core and filter containing the filter core |
| CN109865316A (en) * | 2019-04-01 | 2019-06-11 | 上海易创分析仪器有限公司 | A kind of liquid-phase chromatographic column of recent specifications |
| CN109956595A (en) * | 2017-12-22 | 2019-07-02 | 托普瑞德（无锡）设计顾问有限公司 | A kind of energy saving water purifier based on ion exchange technique |
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-
2022
- 2022-09-29 CN CN202211203228.1A patent/CN115569674A/en active Pending
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| CN212017011U (en) * | 2020-04-27 | 2020-11-27 | 东西分析(永清)仪器有限公司 | High-efficiency filter |
| CN214714521U (en) * | 2021-04-27 | 2021-11-16 | 张掖市林业科学研究院 | Chromatographic column for separating red date crude polysaccharide |
| CN113522386A (en) * | 2021-07-19 | 2021-10-22 | 中国科学院地球化学研究所 | Improved karuss tube assembly |
| CN217450195U (en) * | 2022-02-18 | 2022-09-20 | 成都理工大学 | Anti-embolism assembled ion exchange column |
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