CN115569088A - Pretreatment composition for cosmetics and preparation method and application thereof - Google Patents
Pretreatment composition for cosmetics and preparation method and application thereof Download PDFInfo
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- CN115569088A CN115569088A CN202211147858.1A CN202211147858A CN115569088A CN 115569088 A CN115569088 A CN 115569088A CN 202211147858 A CN202211147858 A CN 202211147858A CN 115569088 A CN115569088 A CN 115569088A
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- Prior art keywords
- ceramide
- cosmetics
- pretreatment composition
- cosmetic
- lotion
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- 239000000203 mixture Substances 0.000 title claims abstract description 94
- 239000002537 cosmetic Substances 0.000 title claims abstract description 78
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 229940106189 ceramide Drugs 0.000 claims abstract description 57
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims abstract description 48
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims abstract description 48
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims abstract description 48
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims abstract description 47
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 29
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 239000006210 lotion Substances 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 15
- -1 glyceramide ethyl methacrylate Chemical compound 0.000 claims description 14
- 239000003755 preservative agent Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 150000001783 ceramides Chemical class 0.000 claims description 9
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N 1-Tetradecanol Natural products CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000011259 mixed solution Substances 0.000 claims description 8
- 229920000223 polyglycerol Polymers 0.000 claims description 8
- 230000002335 preservative effect Effects 0.000 claims description 8
- 229920005862 polyol Polymers 0.000 claims description 7
- 150000003077 polyols Chemical class 0.000 claims description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 4
- 229960005323 phenoxyethanol Drugs 0.000 claims description 4
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 3
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 229920001451 polypropylene glycol Polymers 0.000 claims description 3
- AVBJHQDHVYGQLS-UHFFFAOYSA-N 2-(dodecanoylamino)pentanedioic acid Chemical compound CCCCCCCCCCCC(=O)NC(C(O)=O)CCC(O)=O AVBJHQDHVYGQLS-UHFFFAOYSA-N 0.000 claims description 2
- AGNTUZCMJBTHOG-UHFFFAOYSA-N 3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]propane-1,2-diol Chemical compound OCC(O)COCC(O)COCC(O)CO AGNTUZCMJBTHOG-UHFFFAOYSA-N 0.000 claims description 2
- XPFCZYUVICHKDS-UHFFFAOYSA-N 3-methylbutane-1,3-diol Chemical compound CC(C)(O)CCO XPFCZYUVICHKDS-UHFFFAOYSA-N 0.000 claims description 2
- BBAFBDLICMHBNU-MFZOPHKMSA-N N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine Chemical compound CCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC BBAFBDLICMHBNU-MFZOPHKMSA-N 0.000 claims description 2
- SFNDYIVAFUGZQI-UHFFFAOYSA-N N-hydroxy-N-(3-hydroxy-3-tetradecoxypropyl)decanamide Chemical compound C(CCCCCCCCCCCCC)OC(CCN(C(CCCCCCCCC)=O)O)O SFNDYIVAFUGZQI-UHFFFAOYSA-N 0.000 claims description 2
- KZTJQXAANJHSCE-OIDHKYIRSA-N N-octodecanoylsphinganine Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)CCCCCCCCCCCCCCC KZTJQXAANJHSCE-OIDHKYIRSA-N 0.000 claims description 2
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 229920000289 Polyquaternium Polymers 0.000 claims description 2
- GCDXVKZXCQGDHC-BLCQCPAESA-N [30-oxo-30-[[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]amino]triacontyl] (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC GCDXVKZXCQGDHC-BLCQCPAESA-N 0.000 claims description 2
- 239000006096 absorbing agent Substances 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 229940086668 ceramide eop Drugs 0.000 claims description 2
- 229930183167 cerebroside Natural products 0.000 claims description 2
- 239000002738 chelating agent Substances 0.000 claims description 2
- 239000002781 deodorant agent Substances 0.000 claims description 2
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 2
- 239000000686 essence Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 230000001815 facial effect Effects 0.000 claims description 2
- 150000002305 glucosylceramides Chemical class 0.000 claims description 2
- 150000002339 glycosphingolipids Chemical class 0.000 claims description 2
- 239000003906 humectant Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 230000003020 moisturizing effect Effects 0.000 claims description 2
- SLCVBVWXLSEKPL-UHFFFAOYSA-N neopentyl glycol Chemical compound OCC(C)(C)CO SLCVBVWXLSEKPL-UHFFFAOYSA-N 0.000 claims description 2
- 239000002453 shampoo Substances 0.000 claims description 2
- 239000002562 thickening agent Substances 0.000 claims description 2
- 230000001256 tonic effect Effects 0.000 claims description 2
- CAYHVMBQBLYQMT-UHFFFAOYSA-N 2-decyltetradecan-1-ol Chemical compound CCCCCCCCCCCCC(CO)CCCCCCCCCC CAYHVMBQBLYQMT-UHFFFAOYSA-N 0.000 claims 4
- 238000002203 pretreatment Methods 0.000 claims 4
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims 2
- 229940043375 1,5-pentanediol Drugs 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 230000002567 autonomic effect Effects 0.000 claims 1
- 150000001784 cerebrosides Chemical class 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 229940051250 hexylene glycol Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229930000756 phytoceramide Natural products 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 239000002245 particle Substances 0.000 description 10
- 238000012360 testing method Methods 0.000 description 9
- 238000009472 formulation Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 6
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 description 4
- 125000001931 aliphatic group Chemical group 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 3
- 230000003381 solubilizing effect Effects 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000002411 adverse Effects 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- JSPNNZKWADNWHI-PNANGNLXSA-N (2r)-2-hydroxy-n-[(2s,3r,4e,8e)-3-hydroxy-9-methyl-1-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]heptadecanamide Chemical compound CCCCCCCCCCCCCCC[C@@H](O)C(=O)N[C@H]([C@H](O)\C=C\CC\C=C(/C)CCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JSPNNZKWADNWHI-PNANGNLXSA-N 0.000 description 1
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241001163455 Eulepidotis superior Species 0.000 description 1
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 229940124532 absorption promoter Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- RIZIAUKTHDLMQX-UHFFFAOYSA-N cerebroside D Natural products CCCCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=C(C)CCCCCCCCC)COC1OC(CO)C(O)C(O)C1O RIZIAUKTHDLMQX-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 1
- 229960004705 kojic acid Drugs 0.000 description 1
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 239000007908 nanoemulsion Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229940092258 rosemary extract Drugs 0.000 description 1
- 235000020748 rosemary extract Nutrition 0.000 description 1
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007785 strong electrolyte Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/49—Solubiliser, Solubilising system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a pretreatment composition for cosmetics, which mainly comprises ceramide and a nonionic surfactant, and also discloses a pretreatment composition comprising a polyalcohol, a preparation method thereof and application thereof in cosmetics. And the compatibility of the components and contents of the pretreatment composition leads to excellent transparency and stability over time of cosmetics prepared by using the pretreatment composition as a raw material.
Description
Technical Field
The invention relates to a composition for cosmetics, in particular to a pretreatment composition for cosmetics capable of enhancing the transparency of the cosmetics, a preparation method and application thereof, belonging to the technical field of cosmetics.
Background
Cosmetic and personal care compositions are often required to have a variety of visual and functional attributes. Clear, transparent compositions are often the most desirable choice, for example, to appeal to the consumer, but when some beneficial active is incorporated, problems such as product cloudiness and discoloration often result due to the nature of the active itself.
Ceramide is a substance having high crystallinity, is insoluble in water, has low solubility in other oil agents, and is easily crystallized at low temperature, and therefore, when ceramide is introduced into a cosmetic, there has been a problem that the stability with time is poor. However, it is difficult to sufficiently reduce the particle size of dispersed particles of ceramide, and there is a problem that transparency of the cosmetic cannot be obtained.
Ceramides, which are excellent in skin care effects, are very easily crystallized, and even when they are prepared as stable dispersions, they are still precipitated in the form of crystals in the subsequent storage period after being mixed with base components of cosmetics, thus adversely affecting the transparent appearance of cosmetics.
At present, many techniques have been studied to solve the problem of transparentization of cosmetics containing ceramide.
Such as: the invention patent CN101214198A discloses a ceramide nano liposome preparation, which comprises: 0.1 to 5 weight percent of ceramide, 1 to 20 weight percent of phospholipid, 10 to 70 weight percent of glycerol, 25 to 80 weight percent of water and the like are mixed and emulsified evenly at the temperature of between 60 and 80 ℃ in sequence, and finally, the ceramide nanoliposome preparation which is transparent or semitransparent and has the average grain diameter of less than 100nm can be obtained by processing the mixture by a high-pressure homogenizer. However, the technical scheme has adverse effects on production equipment and energy consumption due to the adoption of a high-pressure homogenization treatment method, and a product with a very transparent appearance is difficult to obtain when the content of ceramide is relatively high.
Patent CN105456045B provides a transparent gel-like aqueous cosmetic, which contains 0.5 to 5% by mass of a copolymer selected from PEG-240/decyltetradecyltetradecylpolyether-20/hexamethylene diisocyanate, distearyl PEG/PPG-8/6 copolymer, 0.1 to 1000ppm of acylceramide, a nonionic surfactant having an acylceramide content of 0.1 times or more, an anionic surfactant having an acylceramide content of 0.01 times or more, and water, based on the total mass of the cosmetic. The composition has good transparency, but the preparation of the composition requires devices such as ultrasonic homogenization, ultrahigh pressure emulsification and the like. Meanwhile, it has a high viscosity due to its high polymer content, it is greatly restricted in formulation of cosmetic formulations, and the content of ceramide in the composition is low.
Patent application CN109843257A provides a transparent cosmetic composition having excellent ceramide dissolution stability, comprising (a) 0.00001 to 5.0 wt% of ceramide, (b) 0.1 to 5.0 wt% of polyglycerol aliphatic ether, and (c) water, wherein the content of polyglycerol mono-aliphatic ether is preferably 75 wt% or more of the total amount of polyglycerol aliphatic ether, and the content of polyglycerol di-aliphatic ether is preferably 5 wt% or less of the total amount of polyglycerol aliphatic ether. However, the technical solution still cannot solve the problem of transparency and stability of high ceramide content. The ceramide transparent solution of the technical scheme is easy to be turbid at high temperature and easy to be separated out at low temperature, and is sensitive to other oil-soluble components in the product.
Patent CN106456516B provides a composition in the form of a nanoemulsion or microemulsion, comprising: (a) at least one oil; (b) At least one nonionic surfactant having an HLB value of 8.0 to 14.0, preferably 9.0 to 13.5, and more preferably 10.0 to 13.0; (c) at least one ceramide compound; (d) at least one anionic surfactant; and (e) water. However, in the technical scheme, the transparency of the compound still cannot meet the requirement, and the transparency stability of the compound with high content of ceramide is poor.
Patent CN106061462B discloses a ceramide dispersion composition, which mainly addresses the problem of the temporal stability of ceramide, but this technical scheme only addresses that the average particle size of dispersed particles of ceramide is less than 60nm, the temporal stability is excellent under high temperature conditions and the skin care effect is excellent, but the problem of transparency of cosmetics is not clearly identified, and this technical scheme specifically limits the kind of ceramide and the nonionic surfactant to polyglycerol fatty acid ester, and the conditions are more limited and the versatility is not strong. And the nonionic surfactant does not exist in an ionic state in the solution, so that the nonionic surfactant has high stability, is not easily influenced by the existence of strong electrolyte, acid and alkali, has good compatibility and has good solubility in various solvents.
Studies on the transparency effect of compositions have also been reported in the prior art, for example:
JP2017149673A discloses a cosmetic composition containing 20-50 wt% of rosemary extract containing ursolic acid. The ratio of polyol to nonionic surfactant is 10:1-1:5, the composition is transparent and suitable for long-term storage, but no ceramides are involved in the composition.
WO2011102001A1 discloses a composition comprising a non-ionic surfactant, kojic acid and at least one perfume and fatty compound. The composition has excellent temperature stability and transparency, but the composition also does not involve ceramides.
Disclosure of Invention
Aiming at the defects in the prior art, the invention mainly aims to provide a pretreatment composition for cosmetics, which can ensure that the cosmetics have excellent transparency and strong stability over time.
In order to achieve the purpose of the invention, the invention adopts the technical scheme that:
the invention provides a pretreatment composition for cosmetics, which comprises the following components in percentage by mass:
ceramide (b): 0.01 to 5.0 percent;
nonionic surfactant: 0.1 to 10 percent;
the above-mentioned nonionic surfactant may be at least one selected from PPG-6 decyltetradecyltetradecyltehy-30, PPG-6 decyltetradecyltehy-12, PPG-13 decyltetradecyltehy-24, and PPG-6 decyltetradecyltehy-20, wherein the solubilizing effect of PPG-6 decyltetradecyltehy-30 and PPG-6 decyltetradecyltehy-20 on ceramide is more excellent.
The mass percentage of the nonionic surfactant in the composition may be preferably 5 to 10%, and more preferably 6 to 8%.
Furthermore, the weight percentage of the ceramide in the composition can be 0.1-5%, preferably 1-5%, and more preferably 3-5%, so as to achieve the optimal compounding effect.
The ceramide is preferably at least one selected from the group consisting of plant ceramides, biological ceramides and ceramides, and the nonionic surfactant preferred in the present invention exhibits an excellent solubilizing effect with respect to the ceramide.
More specifically, the above-mentioned vegetable ceramide is selected from the group consisting of glycosphingolipid, cerebroside, and glucosylceramide.
The biological ceramide is selected from ceramide EOP, ceramide NS/ceramide NG, ceramide NP, ceramide AS, and ceramide AP.
The ceramide is selected from N-lauroyl-L-glutamic acid di (phytosterol/2-octyldodecyl) ester, glyceryl amidoethyl methacrylate/stearyl methacrylate copolymer, polyquaternium 51, and N- (tetradecyloxy hydroxypropyl) -N-hydroxydecanamide.
In order to achieve the object of the present invention, the present invention also provides a preparation method of the pretreatment composition for cosmetics, specifically: weighing the raw materials according to the mass percentage of each component, firstly adding the nonionic surfactant into the ceramide heated to 70-90 ℃, stirring and mixing at the rotating speed of 45-50 r/min, then adding the water with the temperature of 70-80 ℃ into the mixture, stirring the mixed solution at the rotating speed of 45-50 r/min again until the mixed solution is transparent, finally adding the preservative under the condition of 40-45 ℃, and stirring uniformly to obtain the pretreatment composition for the cosmetics.
The invention also discloses a pretreatment composition for cosmetics, which comprises the following components in percentage by mass:
ceramide: 0.01 to 5.0 percent;
nonionic surfactant: 0.1 to 10 percent;
polyol: 5 to 30 percent;
water: the balance of the weight percentage is as follows,
the non-ionic surfactant is at least one selected from PPG-6 decyl tetradecyl alcohol polyether-30, PPG-6 decyl tetradecyl alcohol polyether-12, PPG-13 decyl tetradecyl alcohol polyether-24 and PPG-6 decyl tetradecyl alcohol polyether-20.
Still further, the cosmetic pretreatment composition further comprises a proper amount of preservative, wherein the preservative is at least one of p-hydroxyacetophenone, hexanediol, phenoxyethanol and pentanediol, and a complex of p-hydroxyacetophenone and hexanediol is preferably selected in the cosmetic pretreatment composition without polyhydric alcohol; while pentanediol is preferred in cosmetic pretreatment compositions containing polyols.
The above polyols may be selected from: glycerol, diglycerol, triglycerol, polyglycerol, butanediol, isoprene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, ethylene glycol, diethylene glycol, neopentyl glycol, 1, 2-pentanediol, 1, 2-hexanediol, dipropylene glycol.
The addition of the polyalcohol component has a further enhancement effect on the solubilizing effect of the nonionic surfactant on ceramide, the dissolving time of the polyalcohol is short, the effects of the whole composition system (micro-water system) on the solubility and the dispersibility are obviously improved, the temperature application range of the product is widened, for example, the nonionic surfactant is greatly influenced by low temperature, and after the polyalcohol is added, the CMC of the system is improved, so that the whole composition system has a good antifreezing effect.
Synchronously, the invention also provides a preparation method of the pretreatment composition for cosmetics with the polyol component, which comprises the following steps:
weighing the raw materials according to the mass percentage of each component, firstly adding the nonionic surfactant and the polyhydric alcohol into the ceramide heated to 70-90 ℃, stirring and mixing the mixture at the rotating speed of 45-50 r/min until the mixture is transparent, then adding the water with the temperature of 70-80 ℃ into the mixture, stirring the mixed solution at the rotating speed of 45-50 r/min again, finally adding the preservative at the temperature of 45-50 ℃, and stirring the mixture uniformly to obtain the pretreatment composition for the cosmetics.
Further, the present invention applies the above-mentioned pretreatment composition for cosmetics (including a pretreatment composition for cosmetics containing a polyhydric alcohol or not containing a polyhydric alcohol) to the preparation of cosmetic products.
Of course, the above-mentioned cosmetics include not only the pretreatment composition for cosmetics but also, of course, cosmetically acceptable auxiliary materials such as thickeners, humectants, ultraviolet absorbers, absorption promoters, antioxidants, pH adjusters, chelating agents, perfumes, preservatives and the like. Of course, the person skilled in the art will be careful to select the adjuvants with which the advantageous properties of the cosmetic pretreatment compositions according to the invention and of the cosmetics to which they are applied are not, or substantially not, impaired.
Further, in order to achieve a more reasonable formula effect, the pretreatment composition for cosmetics comprises the following components in percentage by mass in the cosmetics: 5 to 10 percent.
The cosmetic may be any one of moisturizer, shaving lotion, aftershave lotion, cleansing lotion, facial mask lotion, after-sun lotion, bath lotion, body lotion, essence, deodorant lotion, shampoo, hair conditioner, hair tonic, and hair lotion.
Advantageous effects
The ceramide and the nonionic surfactant are compounded, particularly the screened PPG series nonionic surfactant is compounded, so that the prepared pretreatment composition has excellent transparency, can be used as an active substance (skin conditioner) of cosmetics when being applied to the cosmetics, and can also effectively ensure the transparency and the stability of the cosmetics over time.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments.
All tests and measurements were performed under "normal conditions" unless otherwise indicated. The term "conventional conditions" means 20 ℃, 1013hPa and a relative humidity of 50%.
For the purposes of the present disclosure, the term "free from" means that the proportion of the corresponding substances is less than 0.05% by weight. This ensures that "free" according to the invention does not include entrainers and impurities containing these substances.
In this example, the formulation of the cosmetic pretreatment composition is as follows:
example 1
Example 2
Example 3
Example 4
Example 5
The preparation methods of the pretreatment compositions for cosmetics described in examples 1 to 5 above were all as follows: weighing the raw materials according to the mass percent, firstly adding a nonionic surfactant (when containing polyhydric alcohol, the polyhydric alcohol and the nonionic surfactant are sequentially added with ceramide) into ceramide heated to about 85 ℃, stirring and mixing at the rotating speed of about 45r/min, then adding water with the temperature of about 86 ℃ into the mixture, stirring the mixed solution at the rotating speed of about 45r/min again until the mixed solution is transparent, and finally adding preservatives (in example 1, the preservatives are 1, 2-hexanediol and p-hydroxyacetophenone, and the preservatives in examples 2-5 are 1, 2-pentanediol, and naturally, the preservatives can also be phenoxyethanol, pentanediol and the like, particularly, in the pretreatment composition without polyhydric alcohol, the p-hydroxyacetophenone, hexanediol and phenoxyethanol are taken as main components, and in the pretreatment composition containing polyhydric alcohol, the pentanediol is optimally utilized), and stirring uniformly to obtain the pretreatment composition for cosmetics.
The pretreatment compositions for cosmetics obtained in examples 1 to 5 were subjected to turbidity, particle size and refractive index tests, the specific test methods were:
and (3) turbidity testing: the pretreatment composition was subjected to turbidity measurement by a conventional method using an optical turbidimeter.
And (3) particle size testing: the volume average particle size determination of the dispersed particles of the pretreatment composition was carried out using a Malvern particle size potentiometer (Zetasizer Nano-ZS 90) using conventional methods.
And (3) refractive index testing: measuring refractive index with refractometer (agrrefractometer) at 20 + -0.5 deg.C, repeating the reading three times, and taking the average value of the three readings.
The test results are shown in table 2 below:
TABLE 2
As shown in the test results in Table 2: the cosmetic pretreatment composition stages obtained in examples 1 to 5, i.e. superior to the prior art in terms of turbidity, particle size and refractive index, have very good transparency, especially with the advantage of more pronounced transparency of the polyol-free cosmetic pretreatment composition (example 1).
The pretreatment composition described in example 1 above was applied to the serum, and the specific formulation was as shown in example 6:
example 6
The pretreatment composition described in example 2 above was applied to moisturizing water, and the specific formulation was as shown in example 7:
example 7
The pretreatment composition described in example 1 above was applied to a mask solution, and the specific formulation was as shown in example 8:
example 8
The formulations described in examples 6-8 above were prepared by conventional methods to give the corresponding cosmetics (example 6-essence; example 7-moisturizing lotion, example 8-facial mask lotion).
The stability test of the cosmetics prepared according to the formulations described in examples 6 to 8 was carried out by the accelerated test, and the results are shown in Table 2, in which the cosmetics were stored at (40. + -.1) ℃ for 6 months or more (equivalent to the storage stability test data of 3 years or more at room temperature).
| Examples | Initial turbidity | Turbidity at 180 days |
| Example 6 | 1.29/NTU | 1.32/NTU |
| Example 7 | 2.84/NTU | 2.96/NTU |
| Example 8 | 2.28/NTU | 2.33/NTU |
TABLE 2
As can be seen from table 2, cosmetics generally have excellent transparency after the application of the pretreatment composition according to the present invention, and it is seen from the accelerated test that the stability of cosmetics over time is far superior to the prior art.
The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without inventive step based on the embodiments of the present invention, are within the scope of protection of the present invention.
The foregoing description has described the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are given by way of illustration of the principles of the present invention, and that various changes and modifications may be made therein without departing from the spirit and scope of the invention as defined by the appended claims and their equivalents.
Claims (17)
1. The pretreatment composition for cosmetics is characterized by comprising the following active components in percentage by mass:
ceramide: 0.01 to 5.0 percent;
nonionic surfactant: 0.1 to 10 percent;
the non-ionic surfactant is at least one selected from PPG-6 decyl tetradecanol polyether-30, PPG-6 decyl tetradecanol polyether-12, PPG-13 decyl tetradecanol polyether-24 and PPG-6 decyl tetradecanol polyether-20.
2. A pre-treatment composition for cosmetics according to claim 1, wherein the nonionic surfactant is present in the composition in an amount of 5 to 10% by weight, preferably 6 to 8% by weight.
3. A pre-treatment composition for cosmetics according to claim 1, characterized in that the ceramide is present in the composition in an amount of 0.1 to 5% by mass, preferably 1 to 5% by mass, and more preferably 3 to 5% by mass.
4. A cosmetic pretreatment composition according to any of claims 1 to 3, wherein said ceramide is at least one selected from the group consisting of autonomic ceramides, biological ceramides, and ceramides.
5. A pre-treatment composition for cosmetic use according to claim 4, wherein said phytoceramide is selected from the group consisting of glycosphingolipids, cerebrosides, glucosylceramides.
6. A cosmetic pretreatment composition according to claim 4, wherein said biological ceramide is selected from the group consisting of ceramide EOP, ceramide NS/ceramide NG, ceramide NP, ceramide AS, and ceramide AP.
7. A pre-treatment composition for cosmetic use according to claim 4, wherein said ceramide is selected from the group consisting of N-lauroyl-L-glutamic acid bis (phytosterol/2-octyldodecyl) ester, glyceramide ethyl methacrylate/stearyl methacrylate copolymer, polyquaternium 51, N- (tetradecyloxyhydroxypropyl) -N-hydroxydecanoamide.
8. A preparation method of a pretreatment composition for cosmetics according to any one of claims 1 to 7, characterized by weighing raw materials according to the mass percentage of each component, firstly adding a nonionic surfactant into ceramide heated to 70-90 ℃, stirring and mixing at the rotating speed of 45-50 r/min, then adding water at the temperature of 70-80 ℃ into the mixture, stirring the mixed solution at the rotating speed of 45-50 r/min again until the mixed solution is transparent, finally adding a preservative at the temperature of 40-45 ℃, and uniformly stirring to obtain the pretreatment composition for cosmetics.
9. The pretreatment composition for cosmetics is characterized by comprising the following components in percentage by mass:
ceramide (b): 0.01 to 5.0 percent;
nonionic surfactant: 0.1 to 10 percent;
polyol (b): 5 to 30 percent;
water: the balance of the weight percentage is as follows,
the non-ionic surfactant is at least one selected from PPG-6 decyl tetradecyl alcohol polyether-30, PPG-6 decyl tetradecyl alcohol polyether-12, PPG-13 decyl tetradecyl alcohol polyether-24 and PPG-6 decyl tetradecyl alcohol polyether-20.
10. A cosmetic pretreatment composition according to claim 9, further comprising a preservative: proper amount.
11. The cosmetic pretreatment composition of claim 10, wherein the preservative is at least one of p-hydroxyacetophenone, hexylene glycol, phenoxyethanol, and pentylene glycol.
12. A cosmetic pretreatment composition according to claim 9, wherein said polyol is selected from the group consisting of: glycerol, diglycerol, triglycerol, polyglycerol, butanediol, isoprene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, ethylene glycol, diethylene glycol, neopentyl glycol, 1, 2-pentanediol, 1, 2-hexanediol, dipropylene glycol.
13. A method for preparing a pretreatment composition for cosmetics according to any one of claims 9 to 12, characterized by weighing raw materials according to the mass percentage of each component, firstly adding a nonionic surfactant and a polyhydric alcohol into ceramide heated to 70 to 90 ℃, stirring and mixing at a rotating speed of 45 to 50r/min until the ceramide is transparent, then adding water with a temperature of 70 to 80 ℃ into the mixture, stirring the mixed solution at a rotating speed of 45 to 50r/min, finally adding a preservative at a temperature of 45 to 50 ℃, and uniformly stirring to obtain the pretreatment composition for cosmetics.
14. Use of a cosmetic pretreatment composition according to claim 1 or 9 in the preparation of a cosmetic product.
15. The use according to claim 14, wherein the cosmetic comprises a pretreatment composition for cosmetics and acceptable auxiliary materials, and the pretreatment composition for cosmetics comprises the following components in percentage by mass in the cosmetic: 5 to 10 percent.
16. The use of claim 15, wherein the acceptable excipients comprise at least one of thickeners, humectants, uv absorbers, absorption enhancers, antioxidants, pH adjusters, chelating agents, fragrances, preservatives.
17. The use according to claim 14, wherein the cosmetic is any one of moisturizing lotion, shaving lotion, after-shave lotion, cleansing lotion, facial mask lotion, after-sun lotion, body wash, body lotion, essence, deodorant lotion, hair shampoo, hair conditioner, hair tonic, and hair lotion.
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