CN115554197A

CN115554197A - Soothing and repairing composition and application thereof in cosmetics

Info

Publication number: CN115554197A
Application number: CN202111599211.8A
Authority: CN
Inventors: 胡建锋
Original assignee: Ningbo Jiurui Biological Engineering Co ltd
Current assignee: Ningbo Jiurui Biological Engineering Co ltd
Priority date: 2021-12-24
Filing date: 2021-12-24
Publication date: 2023-01-03

Abstract

The invention relates to A61K8, in particular to a soothing and repairing composition and application thereof in cosmetics. The raw materials of the soothing and repairing composition comprise microbial exopolysaccharide, polyalcohol, glucoside compounds and plant extracts, wherein the microbial exopolysaccharide is selected from one or more of xanthan gum, curdlan and locust bean gum. The skin barrier repairing component is compounded by a plurality of plant anti-inflammatory components, so that the skin barrier is repaired while the skin barrier is anti-inflamed and relieved. Through a large number of experimental screens, the advantages are obtained, the proportion is optimized, and the relieving and repairing composition with a remarkable effect is developed. The composition provided by the invention can be added into cosmetics in any dosage form, so that the composition has a soothing and repairing effect. Through the compounding and synergistic effect of specific system substances, the obtained composition has good stability, does not have the problem of precipitation, and is heat-resistant and cold-resistant. Has low irritation, and can improve skin condition of sensitive muscle and increase skin moisture and glossiness.

Description

Soothing and repairing composition and application thereof in cosmetics

Technical Field

The invention relates to A61K8, in particular to a soothing and repairing composition and application thereof in cosmetics.

Background

Environmental deterioration, poor lifestyle, excessive cleaning and cosmetic abuse lead to the development of more and more sensitive muscles. Sensitive muscles refer to the problem of dermatitis such as redness, itching, burning sensation and the like of the skin due to the fact that the barrier function of the skin is damaged and the skin cannot tolerate various physical and chemical stimuli. The reasons for the generation of sensitive muscles are not only related to the skin condition of an individual, such as dry skin, low skin water saturation, and poor skin barrier function; and the oily skin lipid membrane has thick protective layer and good barrier function, so that the skin is not easy to be sensitive. In addition, the neutral care, such as over-washing and makeup, can induce the generation of sensitive muscles and aggravate skin problems. Even the addition of glucocorticoid ingredients to some cosmetics causes the skin to become thinner and more sensitive.

Allergic reactions are reactions of damaged tissues or dysfunctions that occur when an immunized organism is stimulated again with the same antigen. The reaction is characterized by rapid onset, strong reaction and rapid regression; generally, the method does not damage tissue cells, does not cause serious damage to tissues, and has obvious genetic tendency and individual difference. The mechanism of anaphylaxis is a complex and abstract process, and is generally divided into an allergic stage, an excitation stage and an effector stage. The anti-allergy products on the market are numerous, and the anti-allergy products generally follow the principle of simple formula, and use few or no raw materials which easily cause irritation and allergy. Although these products do not easily cause allergy to sensitive skin by themselves, the repairing effect on sensitive skin is not sufficiently remarkable. In addition, there are problems with the stability of these products.

Patent No. CN109453098B provides a soothing and repairing composition and a preparation method and application thereof, which prevents anaphylactic reaction, enhances the barrier function of an organism, relieves skin irritation symptoms and improves skin immunity by compounding aloe barbadensis leaf water, cornflower water and other substances.

Disclosure of Invention

In order to solve the above problems, the present invention provides, in a first aspect, a soothing repair composition, the raw materials of which comprise microbial exopolysaccharides, polyols, glycosides and plant extracts.

As a preferred technical scheme of the invention, the microbial exopolysaccharide is selected from one or more of xanthan gum, curdlan and locust bean gum.

As a preferred technical scheme of the invention, the polyalcohol is selected from one or more of glycerol, 1, 2-pentanediol and butanediol.

As a preferable technical scheme, the glucoside compound is one or more selected from glycerol glucoside, dihydrooat alkaloid D glucoside and stigmastanol maltoside.

Glycerol glucose sweet

The glycerol glucoside has excellent moisture retention, and can promote the expression of aquaporin AQP3, thereby improving the water retention performance of skin epithelial cells. Meanwhile, the glycerol glucoside also has excellent skin permeability, so that the loss of water can be effectively avoided. In addition, when the glycerol glucoside is applied on the skin, the physiological activity of the glycerol glucoside can promote the regeneration of cells and accelerate metabolism.

As a preferable technical scheme, the plant extract is selected from one or more of artichoke extract, chickweed extract, myrobalan extract, cumin extract, valerian extract, shea butter extract and geranium speckle extract.

Cynara scolymus extract

Cynara scolymus, also called artichoke, the extract of which not only enhances the immune function of the skin but also has a soothing and eliminating action on skin allergies due to excessive histamine release.

Chickweed extract

Chickweed is a herbaceous plant of Caryophyllaceae, and its extract can inhibit the activation of human NF-kB cells and the bioactivity of lipoxygenase-5, and has good anti-inflammatory effect. The chickweed extract can activate peroxidase-activated receptor, promote wound skin healing, and eliminate free radicals, and can be used as an antioxidant.

Extract of Terminalia chebula

Terminalia chebula belongs to the family of the monarch family, and its fruit contains tannins. The fructus Chebulae extract can obviously inhibit leukocyte cell and soluble intercellular adhesion molecule, and has good anti-inflammatory effect.

Cuminum cyminum extract

Cuminum cyminum belongs to Cuminum aromatic crops of Umbelliferae, seeds contain volatile oil, and the extract has obvious inhibition effect on leucocyte cells and ICMA-1 (intercellular adhesion molecule-1) and good anti-inflammatory effect.

Valerian extracts

Valerian, which is a plant of valerian genus of Valerianaceae family, has an inhibitory rate of up to 71.7% on the release of interleukin-4 and is useful as an anti-inflammatory agent.

Butyrospermum parkii fruit resin extract

The shea butter extract contains triterpene ester 50-65%, and is beneficial for repairing epidermal barrier.

Extract of Geranium wilfordii

The geranium speckle extract is extracted from geranium speckle, has nourishing effect on skin, and can supplement cell moisture in time, make skin soft and elastic, and make skin show bright water feeling state.

As a preferred technical solution of the present invention, the soothing and repairing composition further comprises lecithin/acrylic acid copolymer sodium.

As a preferred technical solution of the present invention, the soothing repair composition further comprises deionized water.

Preferably, the soothing and repairing composition comprises, by weight, 0.1-0.8 part of microbial extracellular polysaccharide, 8-16 parts of polyol, 0.1-1 part of glycoside compound, 0.1-0.5 part of lecithin/acrylic acid copolymer sodium, 6-23 parts of plant extract and 60.9-85.7 parts of deionized water.

Further preferably, the ratio of glycerol to 1, 2-pentanediol in the polyol is (4-8): (4-8).

More preferably, in the plant extract, the proportions of the artichoke extract, the chickweed extract, the myrobalan extract, the cumin extract, the valerian extract and the shea butter fruit resin extract are (1-5): (1-5): (1-5): (1-5): (1-5): (1-3).

The tanning compound contained in the myrobalan extract is a general name of a class of organic phenolic complex compounds, and can be combined with components such as protein of a cynara scolymus extract to generate a precipitate which is insoluble in water. The applicant finds through a large number of experiments that the problem of precipitate generation can be avoided and the heat and cold resistance of the system can be improved by adding the specific plant extract, and probably because the lecithin/acrylate copolymer sodium and the shea butter fruit resin extract form an emulsification system with high emulsification performance and then are preferentially combined with the protein of the cynara scolymus extract, so that the occurrence of precipitation reaction is reduced, the substances of the system act synergistically, the intermolecular force is increased, and the stability of the system is improved.

As a preferred technical solution of the present invention, the preparation method of the soothing repair composition comprises the following steps: (1) mixing; and (2) emulsifying.

The mixing comprises the following specific steps: mixing lecithin/acrylate copolymer sodium and shea butter fruit resin extract at 35-45 deg.C, stirring for 1-2 hr to obtain phase A; mixing polyalcohol and microbial extracellular polysaccharide, stirring for 0.5-1h, adding deionized water, and stirring for 0.6-1h to obtain phase B;

the emulsification comprises the specific steps of adding phase A, phase B, a artichoke extract, a chickweed extract, a myrobalan extract, a cumin extract and a valerian extract, and stirring for 1-1.5h to obtain the soothing and repairing composition.

In a second aspect, the present invention provides the use of a soothing and healing composition for cosmetic applications.

Preferably, the cosmetics comprise water and light, essence, toner, skin milk and skin cream.

Compared with the prior art, the invention has the following beneficial effects:

(1) The skin barrier repairing component is compounded by a plurality of plant anti-inflammatory components, so that the skin barrier is repaired while the skin barrier is anti-inflamed and relieved. Through a large number of experimental screens, the advantages are obtained, the proportion is optimized, and the relieving and repairing composition with a remarkable effect is developed.

(2) The composition provided by the invention can be added into cosmetics in any dosage form, so that the composition has a soothing and repairing effect.

(3) Through the compounding and synergistic effect of specific system substances, the obtained composition has good stability, does not have the problem of precipitation, and is heat-resistant and cold-resistant.

(4) Has low irritation, and can improve skin condition of sensitive muscle and increase skin moisture and glossiness.

(5) Can be applied to skin without causing skin redness, swelling, itching, tingling and red blood streak.

Detailed Description

Examples

The raw materials for preparing the compositions in the examples are commercially available, wherein xanthan gum is available from shanghai xiangxi ltd, model NovaXan 200T, glycerol is available from shanghai cheng xi ltd, model Mascerol Gly-01,1, 2-pentanediol is available from shanghai cheng xi ltd, model Activonol-5, glycerol glucoside is available from shanghai xiangxi ltd, model GG, lecithin/acrylic acid copolymer sodium is available from shanghai to flexibilizer ltd, model LECIGEL, cynara scolymus (Cynara scolymus l.) extract is available from shanhua ancei ltd, model CJ, chickweed (Stellaria media (l.) Villars) extracts are available from lake african inc, model FL, myrobalan (teralia bulla retz) extracts are available from lake african hoea bioscience ltd, model JZ, cumaria (valium butyrum retz) extracts are available from lake australian company, model nhua, model FL, chezia extracts, cheira, model kom biol technologies ltd.

Example 1

The embodiment provides a soothing and repairing composition which comprises, by weight, 0.3 part of microbial exopolysaccharide, 11 parts of polyol, 0.5 part of glycoside compound, 0.3 part of lecithin/acrylic acid copolymer sodium, 11 parts of plant extract and 60.9 parts of deionized water.

The microbial exopolysaccharide is xanthan gum, the polyalcohol is glycerol and 1, 2-pentanediol, the glucoside compound is glycerol glucoside, and the plant extracts comprise artichoke extracts, chickweed extracts, myrobalan extracts, cumin extracts, valerian extracts and shea butter extracts.

The ratio of glycerol to 1, 2-pentanediol in the polyol is 5:6.

in the plant extracts, the ratio of cynara scolymus extract, chickweed extract, myrobalan extract, cumin extract, valerian extract and shea butter fruit resin extract is 2:3:3:3:2:1.

the preparation method of the soothing and repairing composition comprises the following steps: (1) mixing; and (2) emulsifying.

The mixing comprises the following specific steps: mixing 0.3 part of lecithin/acrylate copolymer sodium and 1 part of shea butter fruit resin extract, and stirring for 1h at 37 ℃ to obtain phase A; mixing polyalcohol and microbial extracellular polysaccharide, stirring for 0.5h, adding deionized water, and stirring for 0.8h to obtain phase B;

the specific steps of the emulsification are adding the phase A and the phase B, and a cynara scolymus extract, a chickweed extract, a myrobalan extract, a cumin extract and a valerian extract, and stirring for 1 hour to obtain the soothing and repairing composition.

Example 2

This example provides a soothing and healing composition, which differs from example 1 in that the proportions of cynara scolymus extract, chickweed extract, myrobalan extract, cumin extract, valerian extract and shea butter extract are 2:3:2:2:1:1.

example 3

This example provides a soothing and healing composition, which differs from example 1 in that the proportions of cynara scolymus extract, chickweed extract, myrobalan extract, cumin extract and valerian extract are 2:3:1:3:2. the shea butter extract was not added.

Example 4

This example provides a soothing and healing composition, which, unlike example 1, comprises 10 parts of vegetable extracts, cynara scolymus extract, chickweed extract, myrobalan extract, cumin extract and shea butter extract in a ratio of 2:3:3:1:1. no valerian extracts were added.

Example 5

The present example provides a soothing and repairing composition, which differs from example 1 in that the soothing and repairing composition comprises 10 parts of vegetable extracts, artichoke extract, chickweed extract, myrobalan extract, valerian extract, shea butter extract in a ratio of 2:2:3:2:1. cuminum cyminum extract was not added.

Example 6

In contrast to example 1, the soothing and healing composition comprises 10 parts of plant extracts, wherein the ratio of cynara scolymus extract, chickweed extract, cumin extract, valerian extract and shea butter extract is 2:3:2:2:1. the extract of fructus Chebulae is not added.

Example 7

This example provides a soothing and healing composition, which, in contrast to example 1, comprises 7 parts of vegetable extracts, cynara scolymus extract, cumin extract, valerian extract, shea butter extract in a ratio of 1:3:2:1. chickweed extract and myrobalan extract were not added.

Example 8

The present example provides a soothing and healing composition, which differs from example 1 in that the soothing and healing composition comprises 10 parts of vegetable extracts, in a ratio of 2:3:4:1. cumin extract and valerian extract were not added.

Example 9

This example provides a soothing and healing composition, which differs from example 1 in that the proportions of cynara scolymus extract, chickweed extract, myrobalan extract and cumin extract are 4:3:3:1. no valerian extract and no shea butter extract were added.

Example 10

This example provides a soothing and healing composition, which differs from example 1 in that the ratio of cynara scolymus extract, chickweed extract, myrobalan extract, shea butter fruit resin extract is 2:3:3:1. no valerian extract or cumin extract was added.

Example 11

This example provides a soothing and healing composition, which differs from example 1 in that the ratio of cynara scolymus extract, chickweed extract, valerian extract, shea butter extract is 3:3:2:1. fructus Chebulae extract and cumin extract are not added.

Example 12

This example provides a soothing and healing composition, which differs from example 1 in that the proportions of cynara scolymus extract, valerian extract, cumin extract and shea butter extract are 2:3:3:2. chickweed extract and myrobalan extract were not added.

Example 13

This example provides a soothing and healing composition, which differs from example 1 in that the proportions of myrobalan extract, cumin extract, valerian extract and shea butter extract are 3:3:2:1. cynara scolymus extract and Stellaria medialis extract were not added.

Example 14

This example provides a soothing and healing composition, which differs from example 1 in that myrobalan extract, cumin extract, valerian extract, shea butter extract, artichoke extract and chickweed extract are not added.

And (3) performance testing:

1. sensory testing: 40 adult subjects were invited, 20 of which had sensitive skin and 20 of which had normal skin. Two approximately 2 cm diameter sections were selected on the inside of each arm and circled with a marker, 0.1.2.3.4.5.6.7.8.9.10.11.12.13. The area was painted with the samples of examples 1-13, 1 with the sample of example 1, and so on. No. 0 was used as a blank control. Then, 1% histamine solution was applied one drop (20 ul) each to the area 0-13. The skin reaction is observed and recorded after 10 minutes, and is graded according to the degree of red, swelling, pruritus and tingling, 40 people take the average value, the value is 0-5, and the larger the value is, the heavier the reaction is. The results are shown in Table 1:

TABLE 1

2. 30 subjects were invited, using the product of example 1 for 30 consecutive days, and skin moisture content was measured before, after 2 weeks, and after 4 weeks, and averaged, as shown in table 2:

TABLE 2

Time	Before use	After 2 weeks of use	After 4 weeks of use
				Water content	30％	45％	52％

3. And (3) appearance test: the soothing repair compositions obtained in examples 1-9 were observed and the results are shown in table 3:

TABLE 3

Examples	Appearance of the product
		1	Clarifying without precipitation
2	Clarifying without precipitation
		3	No clarification and precipitation
4	No clarification and precipitation
		5	No clarification and precipitation
6	No clarification and precipitation
		7	No clarification and precipitation
8	No clarification and precipitation
		9	No clarification and precipitation

4. The soothing and rejuvenating compositions obtained in examples 1 to 9 were tested for moisturizing efficacy according to QB/T4256-2011, with the results shown in table 4:

TABLE 4

5. Heat resistance and cold resistance: the soothing repair compositions obtained in examples 1 to 9 were placed at 5 ℃ and 35 ℃ for 72 hours, respectively, and then observed for appearance, with the results shown in Table 5:

TABLE 5

Examples	Appearance at 5 ℃	Appearance at 35 deg.C
			1	Clarifying without precipitation	Clarifying without precipitation
2	Clarifying without precipitation	Clarifying without precipitation
			3	No clarification and precipitation	No clarification and precipitation
4	No clarification and precipitation	No clarification and precipitation
			5	No clarification and precipitation	No clarification and precipitation
6	No clarification and precipitation	No clarification and precipitation
			7	No clarification and precipitation	No clarification and precipitation
8	No clarification and precipitation	No clarification and precipitation
			9	No clarification and precipitation	No clarification and precipitation

5. And (3) sensitivity test: 80 subjects, adults with sensitive skin 40 and children with sensitive skin 40 were invited, and after 15 days, no allergy appeared on the facial skin by using the composition provided in example 1 every day for 15 consecutive days.

It is understood that the soothing and repairing composition obtained in example 1 does not cause irritation to sensitive muscles and faces when applied to the cheeks of the face, and does not cause redness, swelling, itching, tingling sensation, or redness. The relieving and repairing composition is clear, has no precipitate, good heat resistance and cold resistance and good moisturizing effect.

Claims

1. The soothing and repairing composition is characterized in that raw materials of the soothing and repairing composition comprise microbial exopolysaccharide, polyalcohol, glucoside compounds and plant extracts.

2. A soothing repair composition according to claim 1, wherein the microbial exopolysaccharide is selected from one or more of xanthan gum, curdlan, locust bean gum.

3. A soothing repair composition according to claim 1, wherein the polyol is selected from one or more of glycerol, 1, 2-pentanediol, butanediol.

4. A soothing restorative composition as claimed in claim 1, wherein the glycoside compound is selected from one or more of glycerol glucoside, dihydroavenanthramide D-glucoside, stigmastanol maltoside.

5. The soothing repair composition of claim 1, wherein the plant extract is selected from one or more of cynara scolymus extract, chickweed extract, myrobalan extract, cumin extract, valerian extract, shea butter extract, geranium maculatum extract.

6. The soothing repair composition of claim 5, further comprising lecithin/acrylic copolymer sodium.

7. A soothing repair composition according to claim 6, wherein the soothing repair composition further comprises deionized water.

8. A soothing repair composition according to any one of claims 1 to 7, wherein the soothing repair composition is prepared by a method comprising the steps of: (1) mixing; and (2) emulsifying.

9. Use of a soothing and healing composition according to any of claims 1 to 8, in a cosmetic application.

10. Use of a soothing repair composition according to claim 9 wherein the cosmetic comprises a lotion, essence, toner, milk lotion, cream lotion.