CN115531302A - 一种用于制备治疗角膜血管新生病症的眼用组合物 - Google Patents
一种用于制备治疗角膜血管新生病症的眼用组合物 Download PDFInfo
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- CN115531302A CN115531302A CN202211193746.XA CN202211193746A CN115531302A CN 115531302 A CN115531302 A CN 115531302A CN 202211193746 A CN202211193746 A CN 202211193746A CN 115531302 A CN115531302 A CN 115531302A
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Abstract
Description
全氟萘烷 | 全氟己基辛烷 | 全氟三丁胺 | |
处方1 | 60% | 40% | / |
处方2 | / | 40% | 60% |
组别 | n(只) | 处理 | 剂量 | 给药途径 |
组1 | 6 | 无 | N/A | N/A |
组2 | 6 | 处方1 | 每天三次 | 滴眼液 |
组3 | 6 | 处方2 | 每天三次 | 滴眼液 |
组4 | 6 | 抗小鼠VEGF(1ng/1μL/只眼睛) | 一次注射 | 玻璃体内 |
组5 | 6 | 0.1%*** | 每天三次 | 滴眼液 |
组别 | n(只) | 处理 | 平均CNV(μm<sup>2</sup>) |
组1 | 6 | 无 | 52011 |
组2 | 6 | 处方1 | 27302 |
组3 | 6 | 处方2 | 29065 |
组4 | 6 | 抗小鼠VEGF(1ng/1μL/只眼睛) | 38901 |
组5 | 6 | 0.1%*** | 26403 |
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A.M.JOUSSEN, ET AL: "Effect of gravity in long-term vitreous tamponade:in vivo investigation using perfluorocarbon liquids and semi-fluorinated alkanes", GRAEFE’S ARCH CLIN EXP OPHTHALMOL, vol. 245, pages 665 - 675, XP037834866, DOI: 10.1007/s00417-006-0414-3 * |
COCO RM, ET AL: "Acute retinal toxicity associated with a mixture of perfluorooctane and perfluorohexyloctane: failure of another indirect cytotoxicity analysis", BR J OPHTHALMOL, vol. 0, pages 1 - 6 * |
TATTINI, ET AL: "Gels from a semifluorinated n-alkane in fluorinated solvents as a probe for intermolecular interactions", JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 339, pages 259 - 265, XP026542304, DOI: 10.1016/j.jcis.2009.07.037 * |
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