CN115518204A - Carbomer gel dressing for hemorrhoids - Google Patents
Carbomer gel dressing for hemorrhoids Download PDFInfo
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- CN115518204A CN115518204A CN202110627400.5A CN202110627400A CN115518204A CN 115518204 A CN115518204 A CN 115518204A CN 202110627400 A CN202110627400 A CN 202110627400A CN 115518204 A CN115518204 A CN 115518204A
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- carbomer
- gel dressing
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- hemorrhoid
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Abstract
The invention discloses a carbomer hemorrhoid gel dressing which comprises the following raw materials in parts by weight: 5-24 parts of chitosan, 3-5 parts of carbomer, 6-15 parts of glycerol, 1-2 parts of sodium carboxymethylcellulose, 4-8 parts of lactic acid, 5-15 parts of propylene glycol, 4-6 parts of plant liquid, 1-2 parts of Chinese herbal medicine essence, 0.1-0.2 part of vitamin E and 45-65 parts of purified water, wherein the Chinese herbal medicine essence is composed of one or more of the following components: 5-6 parts of donkey-hide gelatin, 2-3 parts of cordyceps sinensis, 0.8-1.3 parts of ginseng, 1.5-3.5 parts of white drug, 0.2-0.8 part of pawpaw, 0.8-3.5 parts of poria cocos, 0.2-1.2 parts of Chinese yam, 1-2 parts of mulberry and 0.6-0.8 part of liquorice.
Description
Technical Field
The invention relates to the field of carbomer hemorrhoid gel, in particular to carbomer hemorrhoid gel dressing.
Background
The hemorrhoids are lumps formed by pathological hypertrophy and displacement of the anal pad and blood stasis of perianal subcutaneous vascular plexus, and have clinical manifestations of falling and swelling, pain, bleeding or incarceration and the like.
The hemorrhoids mainly comprise internal hemorrhoids, external hemorrhoids and mixed hemorrhoids, and the clinical manifestations of the hemorrhoids are respectively characterized in that the internal hemorrhoids mainly comprise hemafecia and prolapse, the external hemorrhoids mainly comprise swelling pain, pruritus, foreign body sensation and the like, while the mixed hemorrhoids have the clinical manifestations of the internal hemorrhoids and the external hemorrhoids, during the nursing process, a patient needs to keep the local anus clean, develop the good habit of warm water anus hip bath after defecation or before sleeping, maintain a proper amount of exercise every day, particularly for people who need to sit for a long time due to work, strengthen the exercise and carry the anus to exercise, enhance the immunity, and carry the anus to exercise is the recommended exercise method for preventing the hemorrhoids at present.
The carbomer hemorrhoid gel has the effect of adjuvant therapy of hemorrhoid, is very convenient to use, has small irritation, is mainly used for controlling symptoms in hemorrhoid therapy, and can cause reciprocating attack of hemorrhoid symptoms because hemorrhoids without symptoms are not required to be treated, and the traditional carbomer hemorrhoid gel is emphasized to be effective immediately and lacks of long-term therapeutic effect.
Disclosure of Invention
The invention aims to solve the technical problem that the traditional carbomer hemorrhoid gel emphasizes immediate effect and lacks long-term treatment effect, and provides a carbomer hemorrhoid gel dressing, thereby solving the problems.
In order to achieve the purpose, the invention provides the following technical scheme: the carbomer hemorrhoid gel dressing comprises the following raw materials in parts by weight: 5-24 parts of chitosan, 3-5 parts of carbomer, 6-15 parts of glycerol, 1-2 parts of sodium carboxymethylcellulose, 4-8 parts of lactic acid, 5-15 parts of propylene glycol, 4-6 parts of plant liquid, 1-2 parts of Chinese herbal medicine essence, 0.1-0.2 part of vitamin E and 45-65 parts of purified water, wherein the chitosan has good biocompatibility, bioactivity and biodegradability, can be absorbed and utilized by a human body, and can promote the regeneration, repair and healing of the tissue of the hemorrhoids wound; the sodium carboxymethyl cellulose is a good emulsification stabilizer, a thickener and a film-forming agent, can increase the adhesive force of the gel, and can be used together with carbomer to prepare the gel with proper properties; the natural glycerin is extracted from the grease, has strong hygroscopicity and moisture retention, can form a film, has the effect of isolating air, has the effect of preventing water loss, and can prevent the wound of the hemorrhoids from being dried and cracked; lactic acid can improve anus peristalsis activity, and relieve hemorrhoid hemorrhage, pendant swelling, hemorrhoid mucosa congestion, edema, and anal fissure symptoms; propylene glycol and water are used as solvents; the vitamin E is used as antioxidant, and can help to capture and neutralize free radicals, thereby removing the damage of the free radicals to human body and preventing lipid peroxidation of cell membrane.
Further, the Chinese herbal medicine essence is composed of one or more of the following substances: 5-6 parts of donkey-hide gelatin, 2-3 parts of cordyceps sinensis, 0.8-1.3 parts of ginseng, 1.5-3.5 parts of stephanotis, 0.2-0.8 part of pawpaw, 0.8-3.5 parts of poria cocos, 0.2-1.2 parts of Chinese yam, 1-2 parts of mulberry and 0.6-0.8 part of liquorice, wherein the donkey-hide gelatin has the effects of nourishing yin, enriching blood, moistening dryness and stopping bleeding; the cordyceps sinensis has various effects of regulating the function of an immune system, resisting tumor, resisting fatigue, tonifying lung and kidney, stopping bleeding and reducing phlegm, replenishing essence and qi, whitening skin, removing black and the like, and can resist aging and slow down the occurrence of aging and diseases; the ginseng has the functions of promoting protein synthesis, resisting tumor, oxidation, aging, liver injury, gastric ulcer, fatigue, stress, radiation, mutation, bleeding and the like, and has special effects on anemia and malnutrition; the white drug has the effects of removing blood stasis, stopping bleeding, promoting blood circulation, relieving pain, detoxifying and reducing swelling, can accelerate bleeding and shorten the course of disease; the pawpaw contains carotene and rich vitamin C, and the carotene and the vitamin C have strong oxidation resistance, help the organism to repair tissues, eliminate toxic substances, enhance the immunity of the human body and resist the invasion of viruses including influenza A, and the effective components in the pawpaw fruit can improve the efficacy of phagocytic cells; the poria cocos contains pachyman with high content, has an inhibitory effect on various bacteria, can regulate immune function in many aspects, can accelerate the rise of leucocytes caused by chemotherapy, and has a calming effect; the Chinese yam is mainly provided with mucin and can keep the elasticity of blood vessels, tonify qi and enrich blood; the mulberry contains various functional components such as rutin, anthocyanin, resveratrol and the like, has good effects of preventing cancer, resisting aging, resisting ulcer, resisting virus and the like, has the effects of enriching blood, nourishing yin, promoting the production of body fluid, quenching thirst, moistening dryness of the intestine and the like, and is mainly used for treating symptoms such as dizziness and tinnitus, palpitation, dysphoria and insomnia, soreness and weakness of waist and knees, early white hair, thirst, dry mouth, dry stool and the like caused by deficiency of yin and blood; the Glycyrrhrizae radix has antiinflammatory and antiallergic effects.
Further, the plant liquid is composed of one or more of the following components: 5 to 8 parts of aloe, 0.5 to 2.8 parts of menthol, 1 to 3 parts of chamomile and 0.5 to 1.3 parts of geranium, wherein the aloe has the function of promoting the healing and restoration of wounds, has the functions of diminishing inflammation, sterilizing, absorbing heat, reducing swelling, softening skin and keeping cell activity, and the combination of curdlan and callus acid also has the activity of healing wounds and can promote defecation; menthol has the functions of local itching relieving, pain relieving, cooling, slight local anesthesia and the like; chamomile has a remarkable effect on allergic skin, chapped skin and inflamed skin; the geranium essential oil has the functions of stimulating lymphatic system and inducing diuresis, can mutually enhance the two functions, assists the body to quickly and effectively discharge excessive body fluid, and can be used for treating tissue inflammation, fluid retardation and edema.
Furthermore, the carbomer polymer is selected from high-molecular polymers of acrylic acid bonded allyl sucrose or pentaerythritol allyl ether, the carbomer has certain looseness and is a slightly acidic substance with extremely strong dilutability, and in the process of manufacturing the hemorrhoid gel, a proper amount of carbomer is added, so that the viscosity of the substances can be reduced, and the stability of the effective substances can be maintained.
Further, the plant liquid is prepared by extracting aloe, menthol, chamomile and geranium with purified water, filtering to obtain filtrate, and concentrating to obtain the extract which is plant essential oil.
Further, the Chinese herbal medicine essence is prepared by crushing and stirring donkey-hide gelatin, cordyceps sinensis, ginseng, radix stephaniae tetrandrae, pawpaw, poria cocos, chinese yam, mulberry and liquorice, extracting stirred materials in water at 100 ℃ for three times, combining extracting solutions, filtering and concentrating, and the extract is liquid medicine essence.
A preparation method of carbomer hemorrhoid gel dressing comprises the following steps:
step 1: stirring and mixing chitosan, carbomer and sodium carboxymethylcellulose in a certain weight part ratio, and keeping a dissolved substance;
step 2: weighing the Chinese herbal medicine essence, the plant liquid, the vitamin E and the purified water according to the weight part ratio, pouring the mixture into the same container, stirring for 2-7 min, and keeping the additive solution A;
and step 3: weighing glycerol, lactic acid and propylene glycol according to a certain weight part ratio, pouring the mixture into the same container, stirring for 3-6 min, and keeping the additive solution B;
and 4, step 4: and (3) pouring the additive solution A into the additive solution B while stirring, mixing for 5-8 min, pouring the mixed additive solution into the dissolved matter, stirring for 1-2 min for the second time, standing until the mixture is fully swelled, and obtaining the carbomer hemorrhoid gel dressing.
Further, the pH value of the carbomer hemorrhoid gel dressing in the step 4 is between 4.5 and 7.0.
Compared with the prior art, the invention has the following beneficial effects: the carbomer gel dressing for hemorrhoids has the effects of diminishing inflammation, diminishing swelling, stopping bleeding, promoting healing and recovering, has an obvious curative effect of plant essential oil under the action of the essential oil, is used for healing wound surfaces of hemorrhoids, and relieving symptoms of anal tenesmus and pain, mucosal congestion, hematochezia and constipation caused by internal hemorrhoids and mixed hemorrhoids, is prepared from Chinese herbal medicine essence, can tonify qi and enrich blood, has a stable medicinal effect, is suitable for postoperative conditioning, improves body functions, and reduces the risk of relapse.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
Example 1:
the carbomer hemorrhoid gel dressing provided by the invention comprises the following raw materials in parts by weight: 15 parts of chitosan, 4 parts of carbomer, 15 parts of glycerol, 2 parts of sodium carboxymethylcellulose, 8 parts of lactic acid, 13 parts of propylene glycol, 4 parts of plant liquid, 2 parts of Chinese herbal medicine essence, 0.2 part of vitamin E and 45 parts of purified water.
In this embodiment, the herbal essence consists of the following components: 5 parts of donkey-hide gelatin, 3 parts of cordyceps sinensis, 1.3 parts of ginseng, 3 parts of stephanotis, 0.6 part of pawpaw, 2.5 parts of poria cocos, 1.2 parts of Chinese yam, 2 parts of mulberry and 0.8 part of liquorice.
In this example, the plant liquid consisted of the following components: 5 parts of aloe, 2.8 parts of menthol, 1 part of chamomile and 0.5 part of geranium.
In this embodiment, the carbomer polymer is selected from the group consisting of high molecular weight polymers of acrylic acid bonded allyl sucrose or pentaerythritol allyl ether.
In this embodiment, the plant liquid is prepared by extracting aloe, menthol, chamomile, and geranium with purified water, filtering to obtain a filtrate, and concentrating.
In the embodiment, the Chinese herbal medicine essence is prepared by crushing and stirring donkey-hide gelatin, cordyceps sinensis, ginseng, radix stephanotis, pawpaw, poria cocos, chinese yam, mulberry and liquorice, extracting stirred materials in water at 100 ℃ for three times, combining extracting solutions, filtering and concentrating.
A preparation method of carbomer hemorrhoid gel dressing comprises the following steps:
step 1: stirring and mixing chitosan, carbomer and sodium carboxymethylcellulose in a certain weight part ratio, and keeping a solute;
step 2: weighing the Chinese herbal medicine essence, the plant liquid, the vitamin E and the purified water according to the weight part ratio, pouring the mixture into the same container, stirring the mixture for 7min, and keeping the additive solution A;
and step 3: weighing glycerol, lactic acid and propylene glycol according to a certain weight part ratio, pouring into the same container, stirring for 6min, and keeping the additive solution B;
and 4, step 4: and (3) pouring the additive solution A into the additive solution B while stirring, mixing for 6min, pouring the mixed additive solution into the dissolved matter, stirring for 2min twice, standing until the mixture is fully swelled, and obtaining the carbomer hemorrhoid gel dressing.
In this example, the pH of the carbomer hemorrhoid gel dressing in step 4 is between 4.5 and 7.0.
Example 2, compared with example 1, differs in that:
the carbomer hemorrhoid gel dressing provided by the invention comprises the following raw materials in parts by weight: 15 parts of chitosan, 4 parts of carbomer, 15 parts of glycerol, 2 parts of sodium carboxymethylcellulose, 8 parts of lactic acid, 13 parts of propylene glycol, 4 parts of plant liquid, 2 parts of Chinese herbal medicine essence, 0.2 part of vitamin E and 45 parts of purified water.
In this embodiment, the herbal essence consists of the following components: 5 parts of donkey-hide gelatin, 3 parts of cordyceps sinensis, 3.5 parts of radix stephaniae tetrandrae, 0.8 part of pawpaw, 3.5 parts of poria cocos, 2 parts of mulberry and 0.8 part of liquorice.
In this embodiment, the plant liquid is composed of one or more of the following components: 5 parts of aloe, 2.8 parts of menthol, 1 part of chamomile and 0.5 part of geranium.
In this embodiment, the carbomer polymer is selected from the group consisting of high molecular weight polymers of pentaerythritol allyl ether.
A preparation method of carbomer hemorrhoid gel dressing comprises the following steps:
step 1: stirring and mixing chitosan, carbomer and sodium carboxymethylcellulose in a certain weight part ratio, and keeping a dissolved substance;
step 2: weighing the Chinese herbal medicine essence, the plant liquid, the vitamin E and the purified water according to the weight part ratio, pouring the mixture into the same container, stirring the mixture for 7min, and keeping the additive solution A;
and step 3: weighing glycerol, lactic acid and propylene glycol according to a certain weight part ratio, pouring into the same container, stirring for 6min, and keeping the additive solution B;
and 4, step 4: and (3) pouring the additive solution A into the additive solution B while stirring, mixing for 6min, pouring the mixed additive solution into the dissolved matter, stirring for 2min twice, standing until the mixture is fully swelled, and obtaining the carbomer hemorrhoid gel dressing.
Example 3, compared to example 1, differs in that:
the carbomer hemorrhoid gel dressing provided by the invention comprises the following raw materials in parts by weight: 15 parts of chitosan, 4 parts of carbomer, 15 parts of glycerol, 2 parts of sodium carboxymethylcellulose, 4 parts of lactic acid, 13 parts of propylene glycol, 4 parts of plant liquid, 2 parts of Chinese herbal medicine essence, 0.2 part of vitamin E and 45 parts of purified water.
In this embodiment, the herbal essence is composed of one or more of the following components: 6 parts of donkey-hide gelatin, 3 parts of cordyceps sinensis, 1.3 parts of ginseng, 3 parts of radix stephaniae tetrandrae, 0.6 part of pawpaw, 2.5 parts of poria cocos, 1.2 parts of Chinese yam, 2 parts of mulberry and 0.8 part of liquorice.
In this example, the plant liquid consisted of the following substances: 8 parts of aloe and 2.8 parts of menthol.
In this embodiment, the carbomer polymer is selected from the group consisting of high molecular weight polymers of pentaerythritol allyl ether.
A preparation method of carbomer hemorrhoid gel dressing comprises the following steps:
step 1: stirring and mixing chitosan, carbomer and sodium carboxymethylcellulose in a certain weight part ratio, and keeping a dissolved substance;
step 2: weighing the Chinese herbal medicine essence, the plant liquid, the vitamin E and the purified water according to the weight part ratio, pouring the mixture into the same container, stirring for 7min, and keeping the additive solution A;
and 3, step 3: weighing glycerol, lactic acid and propylene glycol according to a certain weight part ratio, pouring into the same container, stirring for 6min, and keeping the additive solution B;
and 4, step 4: and (3) pouring the additive solution A into the additive solution B while stirring, mixing for 6min, pouring the mixed additive solution into the dissolved substance, stirring for 2min twice, standing until the mixture is fully swelled, and thus obtaining the carbomer hemorrhoid gel dressing.
Efficacy experiments, toxicological experiments and stability experiments of the carbomer gel dressing for treating hemorrhoids show that the carbomer gel dressing for treating hemorrhoids has the advantages of remarkable curative effect, no toxicity and good stability, can be used as short-term and middle-term medicaments, is used for experimental treatment of 20 cases of patients with hemorrhoids, improves the cases to 5 cases, enables the patients to relapse for 2 cases after healing, enables 13 cases to not relapse after healing, and has wide application prospect.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. The carbomer hemorrhoid gel dressing is characterized by comprising the following raw materials in parts by weight: 5 to 24 portions of chitosan, 3 to 5 portions of carbomer, 6 to 15 portions of glycerol, 1 to 2 portions of sodium carboxymethylcellulose, 4 to 8 portions of lactic acid, 5 to 15 portions of propylene glycol, 4 to 6 portions of plant liquid, 1 to 2 portions of Chinese herbal medicine essence, 0.1 to 0.2 portion of vitamin E and 45 to 65 portions of purified water.
2. The carbomer hemorrhoid gel dressing of claim 1, wherein the herbal extract is comprised of one or more of the following: 5 to 6 parts of donkey-hide gelatin, 2 to 3 parts of aweto, 0.8 to 1.3 parts of ginseng, 1.5 to 3.5 parts of stephanotis, 0.2 to 0.8 part of pawpaw, 0.8 to 3.5 parts of tuckahoe, 0.2 to 1.2 parts of yam, 1 to 2 parts of mulberry and 0.6 to 0.8 part of liquorice.
3. The carbomer hemorrhoid gel dressing of claim 1, wherein: the plant liquid is composed of one or more of the following components: 5 to 8 parts of aloe, 0.5 to 2.8 parts of menthol, 1 to 3 parts of chamomile and 0.5 to 1.3 parts of geranium.
4. The carbomer hemorrhoid gel dressing of claim 1, wherein: the carbomer polymer is selected from the group consisting of high molecular weight polymers of allyl sucrose or allyl ether of pentaerythritol bonded with acrylic acid.
5. The carbomer hemorrhoid gel dressing of claim 1, wherein: the plant liquid is prepared from Aloe, menthol, chamomile, and flos Pelargonii Hortori by extracting with purified water, filtering to obtain filtrate, and concentrating.
6. The carbomer hemorrhoid gel dressing of claim 1, wherein: the Chinese herbal medicine essence is prepared by crushing and stirring donkey-hide gelatin, cordyceps sinensis, ginseng, radix stephanotis, pawpaw, poria cocos, chinese yam, mulberry and liquorice, extracting stirred substances in water at 100 ℃ for three times, combining extracting solutions, filtering and concentrating.
7. A preparation method of carbomer hemorrhoid gel dressing comprises the following steps:
step 1: stirring and mixing chitosan, carbomer and sodium carboxymethylcellulose in a certain weight part ratio, and keeping a dissolved substance;
step 2: weighing the Chinese herbal medicine essence, the plant liquid, the vitamin E and the purified water according to the weight part ratio, pouring the mixture into the same container, stirring for 2-7 min, and keeping the additive solution A;
and step 3: weighing glycerol, lactic acid and propylene glycol according to a certain weight part ratio, pouring the mixture into the same container, stirring for 3-6 min, and keeping the additive solution B;
and 4, step 4: and (3) pouring the additive solution A into the additive solution B while stirring, mixing for 5-8 min, pouring the mixed additive solution into the dissolved matter, stirring for 1-2 min for the second time, standing until the mixture is fully swelled, and obtaining the carbomer hemorrhoid gel dressing.
8. The method for preparing a carbomer hemorrhoid gel dressing according to claim 7, wherein: the pH value of the carbomer hemorrhoid gel dressing in the step 4 is between 4.5 and 7.0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| US20070269537A1 (en) * | 2003-02-10 | 2007-11-22 | Bioderm Research | Skin Condition Improvement Including Acne, Rosacea, and Topical Wounds by Artemisia Annua Extract via Iron Siderophore Trojan Horse Delivery System |
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Application publication date: 20221227 |