CN1155152A - Charged particle bunch device and operation method thereof - Google Patents
Charged particle bunch device and operation method thereof Download PDFInfo
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- CN1155152A CN1155152A CN 96121604 CN96121604A CN1155152A CN 1155152 A CN1155152 A CN 1155152A CN 96121604 CN96121604 CN 96121604 CN 96121604 A CN96121604 A CN 96121604A CN 1155152 A CN1155152 A CN 1155152A
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Abstract
Charged particle beam device comprise annular charged particle accelerator and irradiation unit. The charged particle beam is irradiated on the irradiation target in the irradiation unit. A charged particle accelerator has a switching device for switching on and off the extraction of a charged particle beam, an irradiation unit has electromagnets for setting an irradiation point of the charged particle beam to be irradiated on an irradiation target, and a control unit controls the switching device to cause it to switch on and off the beam extraction and the electromagnets to cause them to change the irradiation point.
Description
The present invention relates to use the charged particle beam apparatus at charged particle beam treatment cancer and diagnosis impaired position.
JP-A-198397 discloses and a kind ofly will draw around the charged particle beam of charged particle accelerator motion based on the scattering resonance outbound course, will be used for the technology of disease treatment by the charged particle beam that charged particle accelerator is drawn.
A kind of traditional charged particle beam apparatus sees the Rev.Sci.Instrum that publishes in August, 1993.The 64th volume the 8th phase Figure 45 of the 2088th page.Below in conjunction with Fig. 9 the prior art is described.
Among Fig. 9, charged particle beam moves along the Z direction.When transient current was flowed through directions X scanning electro-magnet 101 and Y scanning direction electromagnet 102, these electromagnet produced transient magnetic field, made charged particle beam in directions X (aspect horizontal) and Y direction (vertical direction) scanning.In Fig. 9, the interscan of directions X unit interval (operate often than the unit interval interscan of Y direction, thereby can constitute irradiated site 99 by the number of times of to-and-fro movement operation.The width a of irradiated site 99 and b are determined by the maximum current of directions X scanning electro-magnet 101 and Y scanning direction electromagnet 102 respectively.
But when the irradiation target is complicated shape, when charged particle beam irradiation, must change the sweep length and the sweep velocity of X and Y direction, make charged particle beam can high precision and homogeneous beam current density irradiation on the irradiation target, therefore, the control to the electric current that offers scanning direction electromagnet 101 and Y scanning direction electromagnet 102 is very complicated.
An object of the present invention is to provide a kind of charged particle beam apparatus and method of operating thereof, by simple control, even irradiation target shape complexity, this device also can be with high precision and homogeneous beam current density to irradiation target irradiation charged particle beam.
For achieving the above object, according to the present invention, charged particle accelerator has a switchgear of drawing that is used to open and close charged particle beam, radiation unit is useful on the electromagnet of the exposure spots that the charged particle beam of irradiation to the irradiation target is set, and control module gauge tap device, make it open and close drawing of charged particle beam, and the control electromagnet, make it change exposure spots.
Among the present invention, when switchgear is opened, drawn around the charged particle beam of charged particle accelerator motion, and entered radiation unit, charged particle beam at radiation unit irradiation to the irradiation target.When switchgear cut out by the charged particle beam accelerator to the drawing of radiation unit, the radiation of charged particle beam on irradiation targets also was stopped.Equally, control this switchgear when control module and make it open and close line when drawing, the irradiation to the irradiation target also can be opened and closed.Because electromagnet is provided with the exposure spots of charged particle beam in radiation unit, but is drawn out to the charged particle beam irradiation of radiation unit to the irradiation target from charged particle accelerator.Because control module control electromagnet makes it change exposure spots, charged particle beam can be irradiated onto another exposure spots of irradiation target.
And, in the present invention, radiation dose Target Setting unit is divided into a plurality of irradiated sites with the irradiation target, and the target of definite each irradiated site irradiation dose, the irradiation dose measuring unit is measured the irradiation dose of each irradiated site charged particle beam, and control module is then according to the target of irradiation dose and the irradiation dose gauge tap device that is recorded by the irradiation dose measuring unit.Since control module control electromagnet make charged particle beam when irradiated site changes irradiation at each irradiation zone, even the complicated charged particle beam of irradiation target shape also can be with high precision and beam current density irradiation uniformly.In addition, because control module makes irradiation last till that always the irradiation dose of irradiated site reaches the radiation dose target, even the intensity of charged particle beam is transition, the irradiation target also can be with uniform beam current density by irradiation.
When switchgear is a radio-frequency power feed unit, apply when comprising charged particle beam to charged particle beam around the radio frequency electromagnetic field of free vibration (betatron oscillation) frequency of charged particle accelerator motion, around the free vibration of the charged particle beam of charged particle accelerator motion owing to the radio frequency electromagnetic field that applies enters resonance state, surpass the stability limit of resonance thereby the amplitude that makes the free vibration of charged particle beam strengthens, charged particle beam is drawn from charged particle accelerator.This outbound course is called the scattering resonance outbound course, uses this method, can guarantee to charged particle beam continue draw, thereby make the charged particle beam can homogeneous beam current density irradiation.
In addition, in the treatment of cancer based on charged particle beam, the energy of the charged particle beam of irradiation must be according to the change of the irradiation target degree of depth.For satisfying this requirement, at the charged particle beam of drawing during, can place the energy that the method such as the board-like material of graphite that makes that charged particle beam passes through changes charged particle beam by changing at boost phase around the energy of the charged particle of charged particle accelerator motion or at radiation unit by irradiation.
Fig. 1 is the synoptic diagram of first embodiment of expression charged particle beam apparatus of the present invention.
Fig. 2 is the figure of an example of the relation between the expression damaged part degree of depth and particle beams dosage.
Fig. 3 is the skeleton view of first embodiment of presentation layer and irradiated site.
Fig. 4 is the block diagram of operating unit.
Fig. 5 is the process flow diagram of first embodiment of the method for operation charged particle beam apparatus.
Fig. 6 is the synoptic diagram of expression range converter.
Fig. 7 is the skeleton view of second embodiment of expression irradiated site.
Fig. 8 is the process flow diagram of second embodiment of the method for expression operation charged particle beam apparatus.
Fig. 9 is the perspective illustration of a kind of traditional charged particle beam apparatus of expression.
(embodiment 1)
First embodiment of charged particle beam apparatus of the present invention is described below with reference to Fig. 1.
The charged particle beam apparatus of this embodiment mainly comprises preaccelerator 98, synchrotron 100, rotational stand 110 and control device group 140.The low energy ion of being drawn by preaccelerator 98 is injected into accelerator 100, and is accelerated device 100 and quickens, and is gone into out the rotational stand 110 in the therapeutic room 103 then, makes ion beam can be used as medical treatment.
The main building block of accelerator 100 is described now.Accelerator 100 utilizes the scattering resonance outbound course, wherein the free vibration around the charged particle beam of accelerator 100 motion enters resonance state, and apply a radio frequency electromagnetic field to the charged particle beam that rotatablely moves, to increase its free vibration, thereby guarantee to surpass the stability limit of resonance, charged particle beam is drawn by accelerator.
Present description control unit group 140.Control module group 140 comprises irradiation control module 130, operating unit 131 and accelerator control module 132.
Accelerator control module control charged particle beam by preaccelerator 98 to the drawing of accelerator 100, the acceleration of the charged particle beam that moves around accelerator 100, and the conveying of charged particle beam in rotational stand 110.
With the at first effect of description operation unit 130, explanation is by the method for irradiation control module 130 and accelerator control module 132 operation charged particle line devices then below.
Damaged part information, as the shape of damaged part, the degree of depth and essential irradiation dose R etc. by operator's input operation unit 131.On the basis of the damaged part information of importing, operating unit calculates also determines irradiation zone, and irradiation is to the energy of the charged particle beam of damaged part, and the current amplitude that offers electromagnet 220 and 221.
Relation between the damaged part degree of depth and charged particle beam energy is described here.Fig. 2 represents the relation between the interior degree of depth of body and charged particle beam energy.Fig. 2 represents an example of the relation between the interior degree of depth of body and the charged particle irradiation dose.The peak of irradiation dose shown in Figure 2 is called bragg peak.The irradiation effect of charged particle beam occurs in the bragg peak place.The position of Prague black peak changes with the change of the energy of charged particle beam.Like this, by changing energy according to the degree of depth in the body of damaged part, charged particle beam can be had different-thickness Anywhere at damaged part at depth direction by irradiation.
Fig. 4 shows operating unit 131.
The irradiated site of operating unit 131 constitutes unit 133 and at depth direction damaged part is divided into a plurality of layers on the damaged part information basis of input, usually by Li (i=1,2 ..., N) expression; As shown in Figure 3.Energy calculator 134 determines that according to the degree of depth of each layer suitable beam energy is very much not little, is represented by Ei usually.
And irradiated site tectonic element 133 is determined a plurality of irradiated sites according to the shape of each layer Li, is typically expressed as Ai, j (i=1,2 ... N, J=1,2 ..., M), irradiated site Ai, the mid point Pi of j, the coordinate values of j and mid point (Xij, Yij).Defer to Gaussian distribution because the Strength Space of charged particle beam distributes, operating unit 131 is determined each irradiated site Ai according to the size of charged particle beam by this way, j and mid point Pi thereof, and j makes irradiated site Ai, and j covers adjacent irradiated site a little.Irradiation dose counter 135 is determined each layer mid point Pi according to essential irradiation dose R, the irradiation dose target at j place.
Electromagnet current counter 136 determines to supply with the electric current I Xij and the IYij of electromagnet 220 and 221, so that the center of charged particle beam and each mid point Pi, the j alignment.
The beam energy Ei that operating unit 131 will be determined with respect to each layer Li, each irradiated site Ai, j, mid point Pi, j, irradiation dose Ri, information such as the target of j and electric current I Xij and IYij convey to irradiation control module 130.
Fig. 5 has provided a kind of method of the charged particle beam apparatus of operation present embodiment.
(1) accelerator control module 132 control preaccelerators 98 make its output charged particle beam.
(2) the irradiation control module 130 beam energy size Ei that will wherein store sends accelerator control module 132 to.
(3) accelerator control module 132 accelerates to ENERGY E i to deflection electromagnet 146, four utmost point electromagnet 145 and 11 power supplies of multipolar electromagnetic iron with the charged particle beam that will rotatablely move, and control accelerator power source 165 makes it provide power to radio frequency accelerating cavity 147.
(4) when the charged particle beam of circumnutation is accelerated to ENERGY E i, accelerator control module 132 control accelerator power sources 165 make it to four utmost point electromagnet 145 and 11 power supplies of multipolar electromagnetic iron, to produce the stability limit of free vibration resonance.
When to drawing when applying power with radio frequency applying unit 120, the free vibration amplitude of the charged particle of circumnutation increases, thereby causes the resonance state of the free vibration of charged particle beam to exceed stability limit.
(5) irradiation control module 130 control power supplys 160 make it to electromagnet 220 and 221 power supply stream Ixij and IYij, so that charged particle beam center and selected mid point Pi, the j alignment.
(6) accelerator control module 132 control power supplys 170 make it to four utmost point electromagnet 150 and 151 power supplies of deflection electromagnet, so that the charged particle beam of guiding rotational stand 110 into from accelerator 100 transfers to the damaged part as the irradiation target.
(7) irradiation control module 130 is with the target Rij and certain the concrete mid point Pi that is measured by irradiation dose monitor 200 of irradiation dose, and the dosage of j compares.
(8) if certain concrete mid point Pi, the irradiation dose of j is during less than irradiation dose target Rij, 130 controls of irradiation control module are drawn with radio frequency power source 166 and are made it provide power to drawing with radio frequency applying unit 120, so that line is drawn out to rotational stand 110 by accelerator 100.
When to drawing when providing power with radio frequency applying unit 120, a radio frequency electromagnetic field is applied to the charged particle beam of circumnutation, with the free vibration amplitude of the charged particle beam that increases circumnutation.When the free vibration amplitude increased enough ambassador's free vibration resonance stabilized limit and is exceeded, charged particle beam just was drawn out to rotational stand 110 from accelerator 100.In rotational stand 110, charged particle beam is irradiated onto the irradiated site Ai of selection, j.
(9) irradiation control module 130 compares irradiation dose target Rij with the irradiation dose of another mid point Pij that is recorded by irradiation dose monitor 200.As this mid point Pi, the irradiation dose at j place continues to draw particle during less than irradiation dose target Rij.
(10) as different mid point Pi, when the irradiation dose at j place reached irradiation dose target Rij, irradiation control module 130 control was drawn and with radio frequency power source 166 it is closed to draw.Then irradiation control module 130 control power supplys 160 make charged particle beam center and next irradiated site Ai, the mid point Pi of i+1, j+1 alignment.
(11) when irradiation by irradiated site Ai, j turns to irradiated site Ai, during j+1, under the enough situation of the line of accelerator 100 motion, operation is by the beginning of (5) step, but when the beam intensity and the time of drawing were not enough, operation then went on foot beginning to replenish charged particle beam by (1).
(12) as all irradiated site Ai that select layer Li, when the irradiation dose of j all reaches target, operation by the beginning of (1) step with one deck Li+1 under the irradiation, and with layer Li in same all irradiation layer Ai+1 of mode irradiation, j.
(13) after the irradiation of all layers Li of damaged part is finished, to the EO of charged particle beam apparatus.
Though the energy of charged particle beam is set as Ei in the present embodiment in accelerator 100, the energy of charged particle beam can be changed in rotational stand 110.For example, range converter 500 as shown in Figure 6 is placed near the place before the electromagnet 220 that the line exposure spots is set.Like this, drive range converter 500 to change its thickness, can change energy by the charged particle beam of range converter 500 by making irradiation control module 130.
According to present embodiment, even irradiation target shape complexity, damaged part also can shine with high precision radiation.And, because irradiation one is to lasting till that irradiation dose reaches target, so even beam intensity changes in time, damaged part also can be with the homogeneous beam current density by irradiation.
(embodiment 2)
The following describes the second embodiment of the present invention.The assembly of present embodiment constitutes similar to first embodiment.Every layer of Li of damaged part is not divided into irradiated site at directions X, and only is divided in the Y direction, as shown in Figure 7 but in an embodiment.In other words, irradiated site Ai, j is identical at the directions X width.Another irradiated site Ai, j by the magnetic field intensity that changes electromagnet 220 and produce charged particle beam is scanned at directions X.
Fig. 8 shows a kind of method of the charged particle beam apparatus of operation present embodiment.Except that step (8), other operation stepss are identical with first embodiment.
In step (8), 130 controls of irradiation control module are drawn with radio frequency power source 166 and are made it provide power to drawing with radio frequency applying unit 120, to begin from accelerator 100 line being drawn out to rotational stand 110, in addition, also control power supply 160 in range delta IXij, changing the electric current I ij add to electromagnet 220 so that charged particle beam in directions X scanning by irradiation.
In the present embodiment, the same with described in the embodiment 1 also can change the energy of charged particle beam by using range converter 500 in rotational stand 110.
Though be in the present embodiment by changing the magnetic field intensity that produces by electromagnet 220 charged particle beam is scanned its irradiation to irradiated site Ai at directions X, on the j, also can be by changing the magnetic field intensity that produces by electromagnet 221 charged particle beam being scanned the irradiation that carries out charged particle beam in the Y direction.
Claims (9)
1. a charged particle beam apparatus comprises an endless charged particle accelerator and a radiation unit, and the charged particle beam irradiation that is used for providing from described charged particle accelerator is to an irradiation target,
It is characterized in that, described charged particle accelerator is useful on the switchgear of drawing of opening and closing to described charged particle beam, described radiation unit is useful on the electromagnet of the exposure spots that the described charged particle beam of irradiation to the described irradiation target is set, and settle a control module, to control described switchgear it is opened and closed the drawing of described charged particle beam, and control described electromagnet and make it change described exposure spots.
2. the described charged particle beam apparatus of claim 1, it is characterized in that, described device also comprises and is used for described irradiation target being divided into a plurality of irradiated sites and determining the irradiation dose Target Setting unit of each irradiated site irradiation dose target and be used to measure the irradiation dose measuring unit that the charged particle irradiation dose is stated in each irradiated site place
Wherein, described control module is controlled described switchgear according to the irradiation dose target with by the irradiation dose that described irradiation dose measuring unit records.
3. the described charged particle beam apparatus of claim 1, it is characterized in that, described switchgear is a kind of radio frequency applying unit, is used for applying to described charged particle beam the radio frequency electromagnetic field of the frequency of the free vibration (betatron oscillation) that comprises the described charged particle that moves around described charged particle accelerator.
4. the described charged particle beam apparatus of claim 3 is characterized in that, this device also comprises the energy change device, is used to change the energy of the described charged particle beam of irradiation to the described irradiation target.
5. the described charged particle beam apparatus of claim 4 is characterized in that, described energy change device is installed in the described radiation unit.
6. an operational rights requires the method for 1 described charged particle beam apparatus, it is characterized in that, comprises step:
Open or close drawing to charged particle beam;
Each exposure spots is set; With
Change to another exposure spots from an exposure spots of selecting.
7. an operational rights requires the method for 2 described charged particle beam apparatus,
It is characterized in that, on the irradiation target, determine a plurality of irradiated sites; Determine the irradiation target of each irradiated site; The exposure spots of each irradiated site is set; From the endless charged particle accelerator, draw a charged particle beam; Measure the radiation dose of the above charged particle beam of irradiated site of selecting; Close drawing according to the target of radiation dose and the radiation dose that records to described charged particle beam; Change to another point with exposure spots from the point of described selection.
8. the method for the described operation charged particle beam apparatus of claim 7,
It is characterized in that, apply a radio frequency electromagnetic field to open, stop to impose on the described radio frequency electromagnetic field of described charged particle beam to close drawing to described charged particle beam to the drawing of charged particle beam to described charged particle beam.
9. the method for claim 6 or 7 described operation charged particle beam apparatus is characterized in that, this method also comprises the step of the energy that changes described charged particle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96121604 CN1155152A (en) | 1995-12-11 | 1996-12-11 | Charged particle bunch device and operation method thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP321427/95 | 1995-12-11 | ||
| CN 96121604 CN1155152A (en) | 1995-12-11 | 1996-12-11 | Charged particle bunch device and operation method thereof |
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| CN1155152A true CN1155152A (en) | 1997-07-23 |
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| CN 96121604 Pending CN1155152A (en) | 1995-12-11 | 1996-12-11 | Charged particle bunch device and operation method thereof |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100456416C (en) * | 2001-08-30 | 2009-01-28 | 瓦里安半导体设备联合公司 | Method and apparatus for tuning ion implanters |
| CN101110280B (en) * | 2006-07-17 | 2012-02-29 | 同方威视技术股份有限公司 | Irradiation device and its control method |
| CN102397628A (en) * | 2010-09-14 | 2012-04-04 | 国立癌症中心 | Charged particle beam irradiation control device and charged particle beam irradiation method |
| CN102740929A (en) * | 2010-01-28 | 2012-10-17 | 三菱电机株式会社 | Particle beam treatment apparatus |
| CN101543663B (en) * | 2008-03-28 | 2013-02-27 | 住友重机械工业株式会社 | Charged particle ray irradiation device |
| CN103026803A (en) * | 2010-04-26 | 2013-04-03 | 量子日本股份有限公司 | Charged particle accelerator and charged particle acceleration method |
| CN103458966A (en) * | 2011-04-21 | 2013-12-18 | Gsi重离子研究亥姆霍茨中心有限公司 | Irradiation installation and control method for controlling same |
| CN103458966B (en) * | 2011-04-21 | 2016-11-30 | Gsi重离子研究亥姆霍茨中心有限公司 | Irradiation apparatus and the control method controlling it |
| CN104411361B (en) * | 2012-07-24 | 2016-12-14 | 三菱电机株式会社 | The high audio-frequency control device of accelerator and particle-beam therapeutic apparatus |
| CN106569055A (en) * | 2016-10-19 | 2017-04-19 | 哈尔滨工业大学 | Electronic material and device heat cycle and charged particle irradiation combined environment test method |
| CN108939323A (en) * | 2018-07-11 | 2018-12-07 | 中国科学院近代物理研究所 | Dosage delivery system for particle therapy device |
-
1996
- 1996-12-11 CN CN 96121604 patent/CN1155152A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100456416C (en) * | 2001-08-30 | 2009-01-28 | 瓦里安半导体设备联合公司 | Method and apparatus for tuning ion implanters |
| CN101110280B (en) * | 2006-07-17 | 2012-02-29 | 同方威视技术股份有限公司 | Irradiation device and its control method |
| CN101543663B (en) * | 2008-03-28 | 2013-02-27 | 住友重机械工业株式会社 | Charged particle ray irradiation device |
| CN102740929B (en) * | 2010-01-28 | 2015-07-01 | 三菱电机株式会社 | Particle beam treatment apparatus |
| CN102740929A (en) * | 2010-01-28 | 2012-10-17 | 三菱电机株式会社 | Particle beam treatment apparatus |
| CN103026803A (en) * | 2010-04-26 | 2013-04-03 | 量子日本股份有限公司 | Charged particle accelerator and charged particle acceleration method |
| CN102397628A (en) * | 2010-09-14 | 2012-04-04 | 国立癌症中心 | Charged particle beam irradiation control device and charged particle beam irradiation method |
| CN102397628B (en) * | 2010-09-14 | 2015-04-08 | 国立癌症中心 | Charged particle beam irradiation control device and charged particle beam irradiation method |
| CN103458966A (en) * | 2011-04-21 | 2013-12-18 | Gsi重离子研究亥姆霍茨中心有限公司 | Irradiation installation and control method for controlling same |
| CN103458966B (en) * | 2011-04-21 | 2016-11-30 | Gsi重离子研究亥姆霍茨中心有限公司 | Irradiation apparatus and the control method controlling it |
| CN104411361B (en) * | 2012-07-24 | 2016-12-14 | 三菱电机株式会社 | The high audio-frequency control device of accelerator and particle-beam therapeutic apparatus |
| CN106569055A (en) * | 2016-10-19 | 2017-04-19 | 哈尔滨工业大学 | Electronic material and device heat cycle and charged particle irradiation combined environment test method |
| CN108939323A (en) * | 2018-07-11 | 2018-12-07 | 中国科学院近代物理研究所 | Dosage delivery system for particle therapy device |
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