CN115487164B - Praziquantel pill capable of being put in unmanned aerial vehicle - Google Patents

Praziquantel pill capable of being put in unmanned aerial vehicle Download PDF

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Publication number
CN115487164B
CN115487164B CN202211144214.7A CN202211144214A CN115487164B CN 115487164 B CN115487164 B CN 115487164B CN 202211144214 A CN202211144214 A CN 202211144214A CN 115487164 B CN115487164 B CN 115487164B
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praziquantel
vitamin
unmanned aerial
aerial vehicle
parts
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CN115487164A (en
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游锡火
黄思涵
伍卫平
胡燕
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Hubei Shizhen Health Research Co ltd
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Zhongnong Huawei Biopharmaceutical Hubei Co ltd
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Publication of CN115487164A publication Critical patent/CN115487164A/en
Priority to PCT/CN2023/110076 priority patent/WO2024060838A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/288—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Fodder In General (AREA)

Abstract

The application discloses praziquantel pills capable of being put in an unmanned aerial vehicle, and relates to the technical field of echinococcosis insect repellent medicines, wherein the praziquantel pills capable of being put in the unmanned aerial vehicle consist of praziquantel, a bait layer and a waterproof layer, wherein the bait layer and the waterproof layer are sequentially coated outside the praziquantel from inside to outside, and ventilation holes are formed in the waterproof layer; the bait layer consists of nutritional ingredients, a phagostimulant and a preservative. The praziquantel pill which can be put in an unmanned aerial vehicle can be used for expelling parasites, including echinococcus, from intestinal tracts of dogs and cats in villages and field environments, improves the edibility, the waterproofness and the usability of the insect expelling medicine, and improves the duration of the insect expelling medicine before being eaten in the field environment. The praziquantel pill capable of being put in an unmanned aerial vehicle can be put in a field environment, can be put in a household environment, and does not need to comprise a waterproof layer when being put in the household environment.

Description

Praziquantel pill capable of being put in unmanned aerial vehicle
Technical Field
The application relates to the technical field of echinococcosis anthelmintic drugs, in particular to praziquantel pills which can be put in an unmanned plane.
Background
Echinococcosis, also known as echinococcosis, is a parasitic disease that is common to humans and animals caused by infection of their larvae with echinococcosis. Echinococcosis is often parasitic in the liver of patients, resulting in abdominal pain and cysts. For patients who are already ill, surgery is required to treat them.
Echinococcosis is mainly popular in western, northern and northwest pastures and agriculture and animal pastures in China, and at present, the field echinococcus terminal host has high fecal positive rate and serious field environmental pollution. The risk of infection in the population, dogs and other intermediate hosts is greatly increased by wild sources of infection.
The existing method for preventing echinococcosis is artificial administration. Because the field territory is wide, the geographical environment is complex, the natural condition is bad, the field transmission hosts of echinococcus are numerous and widely distributed, and the artificial drug administration is used for expelling the insects, so that the problems of high difficulty, high cost, poor insect expelling effect and the like exist. At present, manual administration often adopts a mode of wrapping food as bait to induce wild animals to ingest actively. However, animals can not swallow the bait immediately after administration, and the bait is easy to be washed by rain water in a field environment to cause the dissolution of the drug, thereby influencing the insect repellent effect.
Disclosure of Invention
Aiming at the defects in the prior art, the application provides praziquantel pills which can be put in unmanned aerial vehicles. Solves the problems that the existing echinococcosis field anthelmintic has limited waterproof function, is easily influenced by environmental factors to reduce the drug effect and can not be applied to large-area field administration.
The application aims to protect praziquantel pills which can be put in an unmanned aerial vehicle, wherein the praziquantel pills which can be put in the unmanned aerial vehicle consist of praziquantel, a bait layer and a waterproof layer, wherein the bait layer and the waterproof layer are sequentially coated outside the praziquantel from inside to outside, and ventilation holes are formed in the waterproof layer; the bait layer consists of nutritional ingredients, a phagostimulant and a preservative; the nutrient components comprise the following raw material components: corn flour, soybean meal, chicken meal, fishbone meal, salt and cod liver oil; the nutrient components also comprise the following raw material components: vitamin a acetate, vitamin D3, vitamin E acetate, vitamin B1, vitamin B2, vitamin B3, calcium pantothenate, vitamin B6, vitamin B12, ferrous sulfate, copper sulfate, manganese sulfate, zinc sulfate, sodium selenite, calcium iodate; the waterproof layer is one of wax, food-grade resin and food-grade anti-corrosion nano paint.
Preferably, the praziquantel, the bait layer and the waterproof layer are prepared from the following components in parts by weight: 85-81.2:5-8.8.
Preferably, the nutritional ingredients comprise the following raw material components in parts by weight: 35-40 parts of corn flour, 10-20 parts of flour, 30-35 parts of soybean meal, 5-6 parts of chicken powder, 6-8 parts of fishbone powder, 1 part of salt and 1-2 parts of cod liver oil.
Preferably, the nutrient components further comprise the following raw material components in parts by weight: 10000IU/kg of vitamin A acetate, 3 IU/kg of vitamin D, 100IU/kg of vitamin E acetate, 15mg/kg of vitamin B, 25mg/kg of vitamin B, 50mg/kg of vitamin B, 30mg/kg of calcium pantothenate, 66 mg/kg of vitamin B, 0.1mg/kg of vitamin B, 250mg/kg of ferrous sulfate, 14mg/kg of copper sulfate, 60mg/kg of manganese sulfate, 60mg/kg of zinc sulfate, 0.15mg/kg of sodium selenite and 2mg/kg of calcium iodate.
Preferably, the preparation method of the phagostimulant comprises the following steps:
s1, adding distilled water into fresh meat, pulping, heating, adjusting pH, and adding papain for enzymolysis to obtain fresh meat enzymolysis liquid;
s2, adding xylose, L-cysteine hydrochloride, phosphoric acid, a flavoring agent and an antioxidant into the fresh meat enzymolysis liquid, regulating the pH value again, heating, and performing Maillard reaction to obtain a Maillard reaction product;
s3, adding Arabic gum and maltodextrin into the Maillard reaction product to prepare a mixture, and performing spray drying to prepare the phagostimulant.
Further preferably, in step S1, the heating is to 45 ℃, and the pH adjustment is to adjust the pH to 6.5; the weight part ratio of the fresh meat to the distilled water is 1:2.
further preferably, in the step S2, the weight part ratio of the fresh meat enzymolysis liquid, xylose, L-cysteine hydrochloride, phosphoric acid, flavoring agent and antioxidant is 100:4:1:1:5:0.05. in the step S2, the pH is regulated again and heated to be 5.0, and heated to 115 ℃, and the Maillard reaction is carried out for 50min;
further preferably, in step S3, the concentration of maillard reaction products in the mixture is 28-32%; the weight parts ratio of the Arabic gum to the maltodextrin is 1:8.
preferably, the flavoring agent comprises one or more of disodium ribonucleotide and maltol; the antioxidant is 2, 6-di-tert-butyl-p-cresol; the preservative is one of sorbic acid and potassium sorbate.
Preferably, the number of the ventilation holes is 4-8, and the diameter of the ventilation holes is 1-2mm.
The beneficial effects of the application are as follows:
(1) The praziquantel pill which can be put in an unmanned aerial vehicle provided by the application is wrapped with the bait layer outside the praziquantel, so that the special smell of the medicine can be shielded, and the wild animals can be induced to ingest actively; the waterproof layer outside the bait layer can prevent the drug from being dissolved due to the fact that the drug is soaked in rainwater, and further can preserve the drug effect of praziquantel; the vent holes arranged on the waterproof layer can enable the smell of the bait to be dispersed, and the bait is guided to be eaten by dogs or cats.
(2) The praziquantel pill which can be put in an unmanned aerial vehicle can be used for expelling parasites, including echinococcus, from intestinal tracts of dogs and cats in villages and field environments, improves the edibility, the waterproofness and the usability of the insect expelling medicine, and improves the duration of the insect expelling medicine before being eaten in the field environment.
(3) The praziquantel pill which can be put in an unmanned aerial vehicle is suitable for large-area unmanned aerial vehicle putting, can effectively cover bad smell of praziquantel, and increases the food calling effect on wild animals.
(4) The praziquantel pill capable of being put in an unmanned aerial vehicle can be put in a field environment, can be put in a household environment, and does not need to comprise a waterproof layer when being put in the household environment.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. Like elements or portions are generally identified by like reference numerals throughout the several figures. In the drawings, elements or portions thereof are not necessarily drawn to scale.
Fig. 1 is a schematic structural diagram of a praziquantel pill provided by the application, which can be put in an unmanned aerial vehicle;
in the attached drawings, 1-praziquantel, 2-bait layer, 3-ventilation holes and 4-waterproof layer.
Detailed Description
Embodiments of the technical scheme of the present application will be described in detail below with reference to the accompanying drawings. The following examples are only for more clearly illustrating the technical aspects of the present application, and thus are merely examples, and are not intended to limit the scope of the present application.
It is noted that unless otherwise indicated, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this application belongs.
Example 1
The embodiment provides praziquantel pills which can be put in an unmanned aerial vehicle, as shown in fig. 1, the praziquantel pills consist of praziquantel 1, a bait layer 2 and a waterproof layer 4, wherein the bait layer 2 and the waterproof layer 4 are sequentially wrapped outside the praziquantel 1 from inside to outside, and ventilation holes 3 are formed in the waterproof layer 4; the bait layer 2 consists of nutritional ingredients, a phagostimulant and a preservative; the waterproof layer 4 is wax.
The nutritional ingredients comprise the following raw material components in parts by weight: 35 parts of corn flour, 10 parts of flour, 30 parts of soybean meal, 5 parts of chicken meal, 6 parts of fishbone meal, 1 part of salt and 1 part of cod liver oil. The nutrient components also comprise the following raw material components in parts by weight: 10000IU/kg of vitamin A acetate, 3 IU/kg of vitamin D, 100IU/kg of vitamin E acetate, 15mg/kg of vitamin B, 25mg/kg of vitamin B, 50mg/kg of vitamin B, 30mg/kg of calcium pantothenate, 66 mg/kg of vitamin B, 120.1mg/kg of vitamin B, 250mg/kg of ferrous sulfate, 14mg/kg of copper sulfate, 60mg/kg of manganese sulfate, 60mg/kg of zinc sulfate, 0.15mg/kg of sodium selenite and 2mg/kg of calcium iodate.
Wherein, praziquantel 1, bait layer 2 and waterproof layer 4 weight ratio is 10:85:5.
the flavoring agent comprises flavoring nucleotide disodium;
the antioxidant is 2, 6-di-tert-butyl-p-cresol;
the preservative is sorbic acid.
The number of the air holes 3 is 8, and the diameter of the air holes 3 is 1mm.
The preparation method of the phagostimulant comprises the following steps:
s1, adding distilled water into fresh meat, pulping, heating, adjusting pH, and adding papain for enzymolysis to obtain fresh meat enzymolysis liquid;
s2, adding xylose, L-cysteine hydrochloride, phosphoric acid, a flavoring agent and an antioxidant into the fresh meat enzymolysis liquid, regulating the pH value again, heating, and performing Maillard reaction to obtain a Maillard reaction product;
s3, adding Arabic gum and maltodextrin into the Maillard reaction product to prepare a mixture, and performing spray drying to prepare the phagostimulant.
In the step S1, heating to 45 ℃, and adjusting the pH to 6.5; the weight portion ratio of the fresh meat to the distilled water is 1:2.
in the step S2, the weight part ratio of the fresh meat enzymolysis liquid, xylose, L-cysteine hydrochloride, phosphoric acid, flavoring agent and antioxidant is 100:4:1:1:5:0.05. the pH was again adjusted and heated to pH 5.0, heated to 115℃and Maillard reaction was carried out for 50min.
In step S3, the concentration of Maillard reaction products in the mixture is 28%; the weight parts ratio of the Arabic gum to the maltodextrin is 1:8.
example 2
The embodiment provides praziquantel pills which can be put in an unmanned aerial vehicle, as shown in fig. 1, the praziquantel pills consist of praziquantel 1, a bait layer 2 and a waterproof layer 4, wherein the bait layer 2 and the waterproof layer 4 are sequentially wrapped outside the praziquantel 1 from inside to outside, and ventilation holes 3 are formed in the waterproof layer 4; the bait layer 2 consists of nutritional ingredients, a phagostimulant and a preservative; the waterproof layer 4 is a food-grade resin.
The nutritional ingredients comprise the following raw material components in parts by weight: 35 parts of corn flour, 10 parts of flour, 30 parts of soybean meal, 5 parts of chicken meal, 6 parts of fishbone meal, 1 part of salt and 1 part of cod liver oil. The nutrient components also comprise the following raw material components in parts by weight: 10000IU/kg of vitamin A acetate, 3 IU/kg of vitamin D, 100IU/kg of vitamin E acetate, 15mg/kg of vitamin B, 25mg/kg of vitamin B, 50mg/kg of vitamin B, 30mg/kg of calcium pantothenate, 66 mg/kg of vitamin B, 120.1mg/kg of vitamin B, 250mg/kg of ferrous sulfate, 14mg/kg of copper sulfate, 60mg/kg of manganese sulfate, 60mg/kg of zinc sulfate, 0.15mg/kg of sodium selenite and 2mg/kg of calcium iodate.
Wherein, praziquantel 1, bait layer 2 and waterproof layer 4 weight ratio is 10:85:5.
the flavoring agent comprises flavoring nucleotide disodium;
the antioxidant is 2, 6-di-tert-butyl-p-cresol;
the preservative is sorbic acid.
The number of the air holes 3 is 8, and the diameter of the air holes 3 is 1mm.
The preparation method of the phagostimulant comprises the following steps:
s1, adding distilled water into fresh meat, pulping, heating, adjusting pH, and adding papain for enzymolysis to obtain fresh meat enzymolysis liquid;
s2, adding xylose, L-cysteine hydrochloride, phosphoric acid, a flavoring agent and an antioxidant into the fresh meat enzymolysis liquid, regulating the pH value again, heating, and performing Maillard reaction to obtain a Maillard reaction product;
s3, adding Arabic gum and maltodextrin into the Maillard reaction product to prepare a mixture, and performing spray drying to prepare the phagostimulant.
In the step S1, heating to 45 ℃, and adjusting the pH to 6.5; the weight portion ratio of the fresh meat to the distilled water is 1:2.
in the step S2, the weight part ratio of the fresh meat enzymolysis liquid, xylose, L-cysteine hydrochloride, phosphoric acid, flavoring agent and antioxidant is 100:4:1:1:5:0.05. the pH was again adjusted and heated to pH 5.0, heated to 115℃and Maillard reaction was carried out for 50min.
In step S3, the concentration of Maillard reaction products in the mixture is 30%; the weight parts ratio of the Arabic gum to the maltodextrin is 1:8.
example 3
The embodiment provides praziquantel pills which can be put in an unmanned aerial vehicle, as shown in fig. 1, the praziquantel pills consist of praziquantel 1, a bait layer 2 and a waterproof layer 4, wherein the bait layer 2 and the waterproof layer 4 are sequentially wrapped outside the praziquantel 1 from inside to outside, and ventilation holes 3 are formed in the waterproof layer 4; the bait layer 2 consists of nutritional ingredients, a phagostimulant and a preservative; the waterproof layer 4 is food-grade anti-corrosion nano paint.
The nutritional ingredients comprise the following raw material components in parts by weight: 35 parts of corn flour, 10 parts of flour, 30 parts of soybean meal, 5 parts of chicken meal, 6 parts of fishbone meal, 1 part of salt and 1 part of cod liver oil. The nutrient components also comprise the following raw material components in parts by weight: 10000IU/kg of vitamin A acetate, 3 IU/kg of vitamin D, 100IU/kg of vitamin E acetate, 15mg/kg of vitamin B, 25mg/kg of vitamin B, 50mg/kg of vitamin B, 30mg/kg of calcium pantothenate, 66 mg/kg of vitamin B, 120.1mg/kg of vitamin B, 250mg/kg of ferrous sulfate, 14mg/kg of copper sulfate, 60mg/kg of manganese sulfate, 60mg/kg of zinc sulfate, 0.15mg/kg of sodium selenite and 2mg/kg of calcium iodate.
Wherein, praziquantel 1, bait layer 2 and waterproof layer 4 weight ratio is 10:85:5.
the flavoring agent comprises flavoring nucleotide disodium;
the antioxidant is 2, 6-di-tert-butyl-p-cresol;
the preservative is sorbic acid.
The number of the air holes 3 is 8, and the diameter of the air holes 3 is 1mm.
The preparation method of the phagostimulant comprises the following steps:
s1, adding distilled water into fresh meat, pulping, heating, adjusting pH, and adding papain for enzymolysis to obtain fresh meat enzymolysis liquid;
s2, adding xylose, L-cysteine hydrochloride, phosphoric acid, a flavoring agent and an antioxidant into the fresh meat enzymolysis liquid, regulating the pH value again, heating, and performing Maillard reaction to obtain a Maillard reaction product;
s3, adding Arabic gum and maltodextrin into the Maillard reaction product to prepare a mixture, and performing spray drying to prepare the phagostimulant.
In the step S1, heating to 45 ℃, and adjusting the pH to 6.5; the weight portion ratio of the fresh meat to the distilled water is 1:2.
in the step S2, the weight part ratio of the fresh meat enzymolysis liquid, xylose, L-cysteine hydrochloride, phosphoric acid, flavoring agent and antioxidant is 100:4:1:1:5:0.05. the pH was again adjusted and heated to pH 5.0, heated to 115℃and Maillard reaction was carried out for 50min.
In step S3, the concentration of Maillard reaction products in the mixture is 32%; the weight parts ratio of the Arabic gum to the maltodextrin is 1:8.
finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present application, and not for limiting the same; although the application has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the application, and are intended to be included within the scope of the appended claims and description.

Claims (10)

1. A praziquantel pill for unmanned aerial vehicle delivery, which is characterized in that: the praziquantel pill capable of being put in an unmanned aerial vehicle consists of praziquantel, a bait layer and a waterproof layer, wherein the bait layer and the waterproof layer are sequentially coated outside the praziquantel from inside to outside, and ventilation holes are formed in the waterproof layer; the bait layer consists of nutritional ingredients, a phagostimulant and a preservative; the nutrient components comprise the following raw material components: corn flour, soybean meal, chicken meal, fishbone meal, salt and cod liver oil; the nutrient components also comprise the following raw material components: vitamin a acetate, vitamin D3, vitamin E acetate, vitamin B1, vitamin B2, vitamin B3, calcium pantothenate, vitamin B6, vitamin B12, ferrous sulfate, copper sulfate, manganese sulfate, zinc sulfate, sodium selenite, calcium iodate; the waterproof layer is one of wax, food-grade resin and food-grade anti-corrosion nano paint.
2. Praziquantel pill available for unmanned aerial vehicle delivery according to claim 1, wherein: the praziquantel, the bait layer and the waterproof layer are prepared from the following components in parts by weight: 85-81.2:5-8.8.
3. Praziquantel pill available for unmanned aerial vehicle delivery according to claim 1, wherein: the nutritional ingredients comprise the following raw material components in parts by weight: 35-40 parts of corn flour, 10-20 parts of flour, 30-35 parts of soybean meal, 5-6 parts of chicken powder, 6-8 parts of fishbone powder, 1 part of salt and 1-2 parts of cod liver oil.
4. Praziquantel pill available for unmanned aerial vehicle delivery according to claim 1, wherein: the nutrient components also comprise the following raw material components in parts by weight: 10000IU/kg of vitamin A acetate, 33000 IU/kg of vitamin D, 100IU/kg of vitamin E acetate, 115 mg/kg of vitamin B, 25mg/kg of vitamin B, 350 mg/kg of vitamin B, 30mg/kg of calcium pantothenate, 66 mg/kg of vitamin B, 120.1mg/kg of vitamin B, 250mg/kg of ferrous sulfate, 14mg/kg of copper sulfate, 60mg/kg of manganese sulfate, 60mg/kg of zinc sulfate, 0.15mg/kg of sodium selenite and 2mg/kg of calcium iodate.
5. Praziquantel pill available for unmanned aerial vehicle delivery according to claim 1, wherein: the preparation method of the phagostimulant comprises the following steps:
s1, adding distilled water into fresh meat, pulping, heating, adjusting pH, and adding papain for enzymolysis to obtain fresh meat enzymolysis liquid;
s2, adding xylose, L-cysteine hydrochloride, phosphoric acid, a flavoring agent and an antioxidant into the fresh meat enzymolysis liquid, regulating the pH value again, heating, and performing Maillard reaction to obtain a Maillard reaction product;
s3, adding Arabic gum and maltodextrin into the Maillard reaction product to prepare a mixture, and performing spray drying to prepare the phagostimulant.
6. Praziquantel pill available for unmanned aerial vehicle delivery according to claim 5, wherein: in the step S1, the heating is to heat to 45 ℃, and the pH is adjusted to 6.5; the weight part ratio of the fresh meat to the distilled water is 1:2.
7. praziquantel pill available for unmanned aerial vehicle delivery according to claim 5, wherein: in the step S2, the weight parts ratio of the fresh meat enzymolysis liquid, xylose, L-cysteine hydrochloride, phosphoric acid, flavoring agent and antioxidant is 100:4:1:1:5:0.05; in the step S2, the pH is regulated again and heated to be 5.0, and heated to 115 ℃, and the Maillard reaction is carried out for 50min.
8. Praziquantel pill available for unmanned aerial vehicle delivery according to claim 5, wherein: in the step S3, the concentration of Maillard reaction products in the mixture is 28-32%; the weight parts ratio of the Arabic gum to the maltodextrin is 1:8.
9. praziquantel pill available for unmanned aerial vehicle delivery according to claim 5, wherein: the flavoring agent comprises one or more of flavor nucleotide disodium and maltol; the antioxidant is 2, 6-di-tert-butyl-p-cresol; the preservative is one of sorbic acid and potassium sorbate.
10. Praziquantel pill available for unmanned aerial vehicle delivery according to claim 1, wherein: the number of the air holes is 4-8, and the diameter of the air holes is 1-2mm.
CN202211144214.7A 2022-09-20 2022-09-20 Praziquantel pill capable of being put in unmanned aerial vehicle Active CN115487164B (en)

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PCT/CN2023/110076 WO2024060838A1 (en) 2022-09-20 2023-07-31 Praziquantel pill suitable for distribution by unmanned aerial vehicles

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Publication number Priority date Publication date Assignee Title
CN115487164B (en) * 2022-09-20 2023-08-18 中农华威生物制药(湖北)有限公司 Praziquantel pill capable of being put in unmanned aerial vehicle

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