CN115452803B

CN115452803B - Quantum magneto-optical multidimensional sensing method

Info

Publication number: CN115452803B
Application number: CN202211401773.1A
Authority: CN
Inventors: 丁贤根; 丁远彤
Original assignee: Harbour Star Health Biology Shenzhen Co ltd
Current assignee: Harbour Star Health Biology Shenzhen Co ltd
Priority date: 2022-11-09
Filing date: 2022-11-09
Publication date: 2023-03-03
Anticipated expiration: 2042-11-09
Also published as: CN115452803A

Abstract

The quantum magneto-optical multidimensional sensing method is a method for jointly detecting and sensing a nuclear magnetic resonance magnetic spectrum and a scattered light spectrum under a 0-3-dimensional space, which is proposed by an inventor, for a specific molecule containing a specific proton, the scattered light spectrum is associated and calculated from the angle of quantum mechanics according to the change of the vibration change of a molecular bond and the change of magnetic induction signals of the nuclear magnetic spectrum under a magnetization state, a resonance state, a relaxation state and a non-magnetic state, and the solution of the content of the specific molecule or the specific proton can be realized. Specifically, the nuclear magnetic spectrum and the scattered light spectrum of the nuclear magnetic resonance point are detected, the position of the nuclear magnetic resonance point is adjusted and scanned, so that the 0-3-dimensional space coordinate is analyzed, the content of a specific proton or a specific molecule at the point in the detected object is calculated, and the detection is completed. The invention can be used for realizing the detection of specific micromolecules in subcutaneous tissues and blood outside human skin, and designing IVD equipment such as blood sugar, hormone, blood fat and the like.

Description

Quantum magneto-optical multidimensional sensing method

Technical Field

The invention relates to the field of internet and new energy, in particular to fusion innovation of quantum mechanics, nuclear magnetic spectrum and scattered light spectrum, and relates to the field of sensors of medical in-vitro detection instruments. The invention solves the 0-3 dimension magneto-optical sensing and analytic calculation of nuclear magnetic spectrum and scattered light spectrum under the quantum mechanics theory, is beneficial to realizing the product of medical broad-spectrum IVD (human body in-vitro diagnosis product), carries out the ultra-micro detection of pure non-invasive subcutaneous blood and tissue fluid for the human body in vitro, and can also be used for the non-destructive detection of other trace substances such as special food, medicines and the like.

Background

1. Nuclear magnetic spectrum

The nuclear magnetic resonance technology has the core content of a quantum phenomenon, and particularly, the magnetic moment of part of specific protons is magnetized in an external longitudinal constant magnetic field, and because the protons have inherent precession frequency in the magnetic field, the protons generate precession resonance under the action of a transverse excitation radio frequency magnetic field with the same frequency as the precession frequency, and simultaneously after the excitation radio frequency magnetic field is stopped, the free induction attenuation of chemical shift is generated due to the nutation effect of the protons in chemical bonds, so that the content of the specific molecules can be calculated.

According to the resonance process and relaxation process in nuclear magnetic resonance, especially by detecting the free induction decay of chemical shift, the characteristic magnetic spectrum of specific molecules in the detected object can be obtained, and people can further calculate the content of the specific molecules in the detected object by taking the characteristic magnetic spectrum as the 'fingerprint magnetic spectrum' of the specific molecules.

2. Spectrum of scattered light

According to the optical basic principle, light waves are electromagnetic waves in nature. The frequency of visible light is 380-780 nm, and a beam of light (usually called as excitation light) irradiates the surface of an object to generate reflected light, refracted light, diffracted light and scattered light. In macroscopic geometrical optics, the electromagnetic wave reacts when one propagation medium encounters another, according to the law of reflection, the law of refraction, the law of fermat and the law of malus of light. The specific rule is that for reflected light, the reflection angle is equal to the incident angle, and the wavelength of light waves is unchanged; for refracted light, the sine function of the angle of refraction and the angle of incidence is inversely proportional to the refractive indices of the two media; diffraction refers to a physical phenomenon in which a light wave travels away from an original straight line when it encounters an obstacle. It should be noted that reflected light and refracted light are not within the scope of the present discussion, and only scattered light is discussed.

The scattered light is microscopic and conforms to the principle of quantum mechanics. The basic principle is that charged particles, electrons and protons in a substance oscillate under the action of incident electromagnetic waves (excitation light), and charges accelerated by the electromagnetic waves radiate the electromagnetic waves in all directions, which becomes a scattering process, and the generated electromagnetic waves are called scattered light. The scattered light can be classified into the following types.

(1) Rayleigh scattered light

The british physicist rayleigh indicates that when the diameter of the particle is much smaller than the wavelength of the excitation light, rayleigh scattered light is generated with a scattered light intensity almost equal to that of the excitation light, and the scattered light has a certain scattering angle. When the particle is in a static state, generating static Rayleigh scattering light with the same wavelength as the exciting light; when the particles are in a dynamic state, dynamic sharp scattered light with the wavelength widened by the Doppler shift effect compared with the incident light is generated; when the diameter of the particle is much larger than the excitation wavelength, it also generates a scattered light whose intensity is independent of the excitation wavelength. Rayleigh scattered light is elastic scattered light.

(2) Brillouin scattering light

The research of inelastically scattered light related to acoustic phonons and magnetic vibrators by Brillouin scientists in French American scientists indicates that the meta-excitation generated and annihilated in the interaction process of photon and substance emitting scattered light is only acoustic phonons or magnetic vibrators in a low-energy region, the energy range is less than or equal to 0.124meV, and the magnitude of the interaction with photons is 10 ^-18 ～10 ^-17 And has coherence.

(3) Raman scattering light

This phenomenon was discovered in a study of scattered light by raman, an indian physicist, and won the 1930 nobel prize for physics. This phenomenon is: the process of generating and annihilating one-element excitation (one-element excitation of phonon, magnetic vibrator, electron and plasmon) by the transition of two-photon between three energy levels (ground state, virtual state and final state) includes the element excitation of all kinds of elements, rotation and vibration, and the interaction of the optical quantum and the substance emitting scattered light. With an energy range of a few to several hundred and a photon interaction of the order of 10 ^-14 And has non-coherence. Wherein stokes scattered light with the wavelength of the scattered light being larger than that of the excitation light and anti-stokes scattered light with the wavelength of the scattered light being smaller than that of the excitation light are included.

(4) Thomson scattered light

The british physicist thomson found: the electric field of the electromagnetic wave incident by the exciting light makes the free charged particles generate elastic scattering, and the wavelength of the scattered wave is the same as that of the exciting light. Also, the main cause of particle acceleration is from the electric field component of the incident wave, while the effect of the magnetic field can be neglected. The particles will start to move in the direction of the electric field oscillation, generating electromagnetic dipole radiation. Tomsun's achievement led him to the 1906 prize for nobel physics.

(5) Compton scattered light

The american physicist compton found: the incident excitation light photons are scattered by inelastic collisions with extra-nuclear electrons in the material atoms. Upon collision, the incident photon transfers some of the energy to an electron, causing it to dissociate from an atom into recoil electrons and the scattered photon changes in energy and direction of motion. Among them, the phenomenon in which the wavelength of scattered light is lengthened due to the loss of energy is called compton phenomenon; the shortening of the wavelength of scattered light due to the energy gained by the photons is known as the inverse compton phenomenon. These achievements of compton led him to win the 1927 nobel prize for physics.

(6) Fluorescence of the compound

When excitation light is irradiated to a specific atom, electrons around the nucleus of the atom are transferred from an original orbit to an orbit having higher energy, that is, from a ground state to a higher-order excited singlet state, and the higher-order singlet state is unstable and returns to the ground state, and the energy is released as photons, thereby generating fluorescence. In most cases, the fluorescence light has a longer wavelength and lower energy than the excitation light. However, when the absorption intensity is large, a two-photon absorption phenomenon may occur, resulting in a case where the radiation wavelength is shorter than the absorption wavelength. When the wavelength of the radiation is equal to the absorption wavelength, it is resonance fluorescence. The common example is that substances absorb ultraviolet light and emit visible-band fluorescence, and the principle is that fluorescent lamps in our lives use, and fluorescent powder coated on a lamp tube absorbs ultraviolet light emitted by mercury vapor in the lamp tube and then emits visible light, so that the fluorescent powder can be visible to human eyes and can be used as an illumination light source.

In particular, in the present application, in consideration of the fact that both fluorescence and scattered light have a common basis based on quantum mechanics, we include fluorescence in the category of scattered light as the same category for the convenience of description.

3. Magnetic spectrum spectral correlation

Two patents of the invention granted by the national intellectual property office of China, namely, the quantum magneto-optical sensing method Chinese patent No. CN114441507B, the quantum magneto-optical sensor Chinese patent No. CN114441506B and the quantum scattered light distribution detector based on multi-axis and multi-mode Chinese patent application No. 202210270064.4, are similar innovations applied by the inventor team before, and the main innovation points are firstly proposed: 1. the magnetic spectrum detection of nuclear magnetic resonance is carried out on a detection object containing specific protons, and the scattered light spectrum detection is carried out on the surface of the detection object. 2. And establishing a quantum mechanical equation related to the magnetic spectrum and the optical spectrum, and solving the content of the specific proton and the specific molecule in the detected object. 3. The quantum scattering light presents a thorny ball distribution model, and the establishment of a mathematical model of the statistical distribution of microscopic atoms and macroscopic detection objects is solved.

The invention provides a quantum magneto-optical multidimensional sensing method based on a 0-3 dimensional space on a detected object, and aims to realize more accurate positioning measurement and better application to products in the aspects of non-invasive detection and the like. For example, in the case of non-invasive in vitro detection of the human body (for example, IVD products), the skin interference is a big problem, and in particular, in the case of detecting trace substances in subcutaneous tissues, interstitial fluid and blood vessels in vitro, the problem can be perfectly solved by using multi-dimensional positioning measurement because both magnetic spectrum and optical spectrum cannot resist the interference from skin diversity.

4. Brief description of the existing scattered light detector

In Vitro Diagnostic product IVD (In Vitro Diagnostic products, abbreviated as IVD, and abbreviated as Chinese) is more and more popular and important In medical institutions and detected objects because the In Vitro Diagnostic product IVD performs medical detection by adopting the outside of a human body, which is different from operation and blood drawing test detection, especially non-invasive IVD, and can complete detection without skin breaking. However, since non-invasive IVD is to detect the inside of the human body (such as blood, tissue fluid, subcutaneous tissue, etc.) through the skin of the human body, the innovation of theoretical models and the difficulty of technical implementation are both extremely difficult. Taking the nmr technique as an example, a nmr imaging system inherently contains 17 people to win the nobel prize 12 times, and the raman spectroscopy technique is also the result of gaining the nobel prize.

Trace substance detection product

In the case where the content of ultra-fine substances containing specific protons capable of forming nuclear magnetic resonance, whether in a pure atomic structure solution or in a molecular structure mixture, is very small, detection is difficult, and there are demands for detection, such as detection of trace substances in food, trace substances in medicine, highly toxic substances, and drug-breaking detection.

Spectrum detection product

Scattered light detectors are still a preliminary stage of development compared with other detectors in the field of measurement. Although in recent years, research reports of some special self-developed apparatuses are occasionally reported in some scientific journals for research and exploration, such as experimental apparatuses for femtosecond laser exploration, high-precision raman spectrum acquisition apparatuses, array laser imaging apparatuses, and the like. As a device for commercialization, the following are some kinds of devices searched by the inventors, and the following are introduced.

(1) Coaxial scattered light detector complete machine

By coaxial, it is meant that the emission of excitation light and the reception of scattered light take the same optical axis at the detection point. This is the conventional means based on scattered light detection that is currently available. For example, most of the existing raman detectors, fluorescence detectors, and even active spectrum detectors have a coaxial structure.

(2) Coaxial spectral probe

In order to reduce the cost and emphasize the universality, even manufacturers design the emitting of the excitation light and the receiving of the scattered light into a product called a spectrum detection head, and the structure principle is still a coaxial structure of the excitation light and the receiving light.

(3) In vitro diagnostic product

Typical products for in vitro diagnostics based on coaxial architecture: there is IVD (In Vitro Diagnostic products, abbreviated as IVD, chinese) and because medical detection is performed In Vitro by using human body, it is different from operation and blood drawing test detection, especially non-invasive IVD, and detection can be completed without skin breaking, so it is more and more popular and regarded by medical institutions and detected objects. However, since non-invasive IVD is to detect the inside of the human body (such as blood, tissue fluid, subcutaneous tissue, etc.) through the skin of the human body, the innovation of the theoretical model and the difficulty of technical implementation are both extremely difficult. Taking the nmr technique as an example, one nmr imaging system inherently contains 17 people who win the nobel prize 12 times, and the raman spectroscopy technique is also the result of gaining the nobel prize in physics.

(4) Trace substance detecting product

Trace substance detection product based on coaxial structure: for example, in the case of ultra-fine substances containing specific protons capable of forming nuclear magnetic resonance, whether they are solutions of substances with pure atomic structures or mixtures of substances with molecular structures, the detection is difficult in the case of very small contents, such as trace substances in food, trace substances in drugs, and highly toxic substances, and the need for such detection also exists.

(5) Raman spectroscopy

Raman spectroscopy based on a coaxial structure: the most central theory of Raman spectroscopy is the Raman effect Raman (english name: raman scattering, chinese abbreviation: raman scattering or Raman effect. ChandrasekharaVenkata Raman,1888-1970, indian physicist), which was discovered in 1928 and received the nobel prize in 1930. The core principle of the raman effect is also a quantum phenomenon, in which when a photon of excitation light of a specific wavelength collides with an extra-nuclear electron of an atomic nucleus, the electron absorbs the energy of the photon, and a scattered photon is generated according to the energy conservation principle. Most of the photons are elastically collided, and the wavelength of the ejected photons is consistent with that of exciting light, which is called Rayleigh scattering (English name: rayleigh scattering, chinese short for Rayleigh scattering); in addition, a small part of the scattered light undergoes inelastic collision, and the scattered light has a wavelength different from that of the excitation light because energy level transition of electrons absorbs or releases part of the energy, which is called raman scattered light. The Raman scattering light is divided into a Brillouin scattering light which is called as a Brillouin scattering light and a Stokes scattering light which is called as an Anti-Stokes scattering light (English name: anti-Stokes scattering, chinese short for Anti-Stokes scattering) and a Raman spectrum which is formed by the Brillouin scattering, the Stokes scattering and the Anti-Stokes scattering, wherein the wavelength of the scattering light is slightly different from that of the exciting light (1-10/cm < -1 >), according to the difference of the wavelengths.

Based on the molecular bond and atomic structure of a specific molecule, a fixed raman spectrum can be generated, which is also called as a fingerprint spectrum of the specific molecule, and the content of the specific molecule in a detected object can be further calculated through the fingerprint spectrum.

5. The deficiency of the prior art

From the view of quantum magneto-optical sensing technology (Chinese patent No. CN114441507B of quantum magneto-optical sensing method and Chinese patent No. CN114441506B of quantum magneto-optical sensor), the prior art has not been upgraded to the level of space detection dimensionality, and can not realize accurate positioning measurement of a detected object.

In the prior art, because the scattered light spectrum detection technology adopts a coaxial structure, off-axis detection of excitation light and scattered light cannot be supported, only scattered light with the same optical axis and the opposite direction as the excitation light can be detected, and scattered light at other angles cannot be detected, so that a position point of an optimal wave function or probability distribution and direction cannot be searched, a possible optimal detection point is lost, and optimal detection sensitivity is lost.

6. Objects, intentions and contributions of the invention

Based on the analysis of the defects of the background art and the prior art, the inventor innovates the patent application of the invention, namely the quantum magneto-optical multidimensional sensing method, and the main purposes of the invention comprise:

(1) And introducing a gradient magnetic field to realize dimension control and calculation of nuclear magnetic resonance.

(2) And an off-axis scattered light collection mode is adopted to obtain an optimized excitation light emission angle and an optimized scattered light receiving angle so as to obtain scattered light collection with higher efficiency, and more accurate scattered light spectrum analysis and calculation can be conveniently obtained.

(3) And calculating and analyzing the layered scattered light spectrum according to a layered theory and a scattered light attenuation algorithm.

(4) The quantum magneto-optical multidimensional sensing method realizes plane scanning on a receiving surface of a detected object so as to realize scattered light spectrum detection in at most 3-dimensional space, and perfectly realizes a 0-3-dimensional space by matching with 3-dimensional space scanning of a gradient magnetic field.

The main intents and contributions of the present invention include:

(1) The quantum magneto-optical multidimensional sensing of 0-3 dimensional space is realized by the combined control of a multidimensional gradient magnetic field and a scattered light detection point.

(2) Designing a specific step of the 0-3 dimensional space combined control of the gradient magnetic field and the scattered light.

Disclosure of Invention

1. Core idea of the invention

Theoretical basis of scattered light

According to the principle of scattered light generation, in the microscopic aspect, all the scattered light generation accords with the principle of quantum mechanics, is generated by the interaction of excitation light photons and extra-nuclear electrons of substance atoms, and accords with the energy wave function rule of quantum mechanics. The method comprises the steps of establishing a spherical polar coordinate by taking a detection point irradiated by excitation light as a spherical center and taking incident of received light as a reference, presenting probability distribution and angle distribution on scattered light on the spherical surface according to the rule of an energy wave function, finding a high-probability area by detecting the probability distribution and the angle distribution, and finding a so-called 'highlight point' so as to further detect a scattered light probability distribution map.

Nuclear magnetic energy wave function

The calculation formula of the energy wave function includes but is not limited to:

formula 1.1 is a rectangular three-dimensional coordinate pull-down plateau operator, formula 1.2 is a calculation formula for approximating the planckian constant, formula 1.3 is a schrodinger equation in a rectangular three-dimensional coordinate, formula 1.4 is a spherical polar coordinate pull-down plateau operator, formula 1.5 is a spherical polar coordinate pull-down plateau equation, formula 1.6 is a hamiltonian, formula 1.7 is a schrodinger equation in a spherical polar coordinate, formula 1.8 is a wave function calculation formula for particles, formula 1.9 is a calculation formula for the probability density of particles, formula 1.10 is a total probability function for n quantum numbers, formula 1.11 is a calculation formula for an optimal probability interval,

|Ψ(x,t)| ² ＝|c ₁ | ² |ψ ₁ (x)| ² +|c ₂ | ² |ψ ₂ (x)| ² +2|c ₁ c ₂ ||ψ ₁ (x)ψ ₂ (x)|cos(ωt+δ)1.9

wherein psi ₂ (x) Is the wave function of the particle, | Ψ (x, t) & gt ² Is the probability density of the particle, c ₁ 、c ₂ Is a complex constant, t is an arbitrary time, ω is an oscillation frequency, θ is an azimuth angle, φ is an elevation angle, r is a radius, δ is a Dirac impulse function, n is a quantum number, | ψ _n (x)| ² Is the probability density of the n-th particle, Q _n Is an overall probability function of n particle numbers, Q _ns Is the optimal probability interval, s is between Q _n A threshold value within the size interval.

Preferably, the angle between the quantum state and the magneto-optical in the nmr is a step of releasing photons by electrons which transit from a low energy level to a high energy level and then fall back from the high energy level to the original low energy level when excited by excitation light, and taking the probability distribution of the released photons as the probability distribution of the raman spectrum signal.

Preferably, the probability distribution of the raman spectrum signal is calculated according to the quantum state and magneto-optical angle of all specific protons in the probe in nuclear magnetic resonance.

Preferably, the maximum probability position in the probability distribution of the raman spectrum signal is obtained, and the position is used as a receiving position of the raman scattered light, and the raman scattered light is received to obtain an optimum nuclear magnetic resonance spectrum.

Preferably, the quantum states include spins of atomic nuclei, spins of specific protons, electron energy levels, electron cloud probabilities, electron energy level transitions.

In practical design, the formula in the present invention is only one of the expressions, and in different academic genres, different formula listing manners are included in the present invention. Those skilled in the art should be able to design the device by referencing the common general information.

Gradient magnetic field and K space

The gradient magnetic field is a magnetic field superposed in the main magnetic field, and the nuclear magnetic resonance frequency of a specific proton of a detected object at a certain position in the magnetic field is linearly proportional to the size of the synthetic magnetic field at the position, so that the size of the synthetic magnetic field of each detection point is changed in sequence in the space of one detection area, the nuclear magnetic resonance points can be scanned, and all spaces of all detection areas can be traversed through scanning.

Wherein, formula 1.12 is the frequency calculation principle of nuclear magnetic resonance, formula 1.13 is the nuclear magnetic resonance frequency of x point in the gradient magnetic field, and formula 1.14 is the partial differential equation set of gradient magnetic field tensor and K space. The basic principles of nuclear magnetic resonance will be understood by those skilled in the art,

ω ₀ ＝γB ₀ 1.12

ω _x ＝γ(B ₀ +xG _x )＝ω ₀ +Δω _x 1.13

wherein, ω is ₀ Is the nuclear magnetic resonance frequency in the static magnetic field, gamma is the magnetic rotation ratio of a specific proton, B ₀ The magnitude of the main magnetic field being stationary. Omega _x Is the nuclear magnetic resonance frequency at the gradient magnetic field x, x being the position in the gradient magnetic field, G _x Being field gradients, Δ ω _x Is the offset of nuclear magnetic resonance. T is the tensor of the gradient magnetic field.

Correlation of nuclear magnetic spectrum with scattered light spectrum

The nuclear magnetic spectrum at least comprises: main magnetic field strength, excitation radio frequency, gradient magnetic field strength, nuclear magnetic resonance frequency, coordinates of a nuclear magnetic resonance point, relaxation signals (free induction decay (FID)), longitudinal relaxation time T1, transverse relaxation time T2, detection time and the like.

The spectrum of the scattered light includes at least frequency shift, intensity, detection time, etc.

Scattered light attenuation

Along with the difference of the properties of the detection objects, when the excitation light irradiates the detection point of the detection object, the excitation light can enter the detection object to a certain depth along the optical axis of the excitation light along the difference of the wavelength of the excitation light and the properties of the detection object in a gradient attenuation mode, namely, the energy of photons gradually attenuates to zero along with the expansion of the depth of entering the detection object, and the scattered light which is emitted to the detection point is gradually attenuated along with the attenuation of the energy of the photons of the excitation light with the depth as the maximum detection depth. When infrared laser with the wavelength of 785nm is used as excitation light, the infrared laser can enter the skin of a human body by about 2mm to 3mm, and the excitation light gradually attenuates along with the change of the depth. The scattered light produced also fades away with increasing depth. In this patent application, we can refer to the correction of the scattered light intensity for the detection layer according to a linear attenuation.

The maximum number of detection layers is calculated based on the depth to which excitation light can enter the test object (e.g., skin), for example, for a laser having a wavelength of 785nm, the maximum depth in the skin of the finger pulp of a human finger is about 3.0mm, while the depth of the epidermis and dermis in the skin is about 1.2mm, for glucose (formula C) ₆ H ₁₂ O ₆ ) Or sodium chloride (formula NaCL) or progesterone (formula C) ₂₁ H ₃₀ O ₂ ) The detection of (2) needs to be performed in the subcutaneous tissue below the dermis, and thus the nuclear magnetic spectrum and scattered light spectrum data of the detection layer in the range of 1.2mm to 2.5mm need to be calculated. In particular in the case of a layered calculation by means of magnetic gradient fields in nuclear magnetic resonance, for the determination of the voxel size, for example of 1.40mm here, the thickness of the voxels of the first layer, here precisely the tissue of the epidermis and dermis, is 1.4mm here, and we do not need to detect the glucose values here, while the voxels of the second layer haveThe layer is between 1.4mm and 2.8mm, which is exactly the position where the user needs to detect glucose, then the excitation magnetic field frequency of the layer is calculated, and according to the frequency, the tissue between 1.4mm and 2.8mm under the finger skin enters a hydrogen nuclear magnetic resonance state, according to the scattered light spectrum obtained under the nuclear magnetic resonance state, the scattered light attenuation of the first layer (1.4 mm) is deducted, so that the scattered light spectrum signal of the detection layer is obtained, and according to the comparison database, the detection content of a specific molecule, namely glucose, is searched and calculated.

Discrimination between nuclear magnetic and scattered light spectra of different molecular structures

For different molecular structures containing specific protons, the nuclear magnetic spectrum and the scattered light spectrum are different due to the difference of covalent bonds and the difference of the content of specific molecules in the analyte. When the content of the specific molecule needs to be detected, a person skilled in the art needs to establish a solution equation according to the differences to solve the content of the specific molecule. Or according to the standard (glucose C) ₆ H ₁₂ O ₆ Or sodium chloride NaCL or progesterone C ₂₁ H ₃₀ O ₂ ) And (4) measuring and establishing a comparison database, and searching and determining.

Off-axis adjustable mode of scattered light spectrum

According to the defects of the prior art, a novel scattered light detector is designed, the coaxial mode of the existing exciting light and the collected scattered light is changed into the off-axis mode, the off-axis included angle is adjustable, and the position of the strongest scattered light is found by adjusting the off-axis included angle.

2. Implementation steps of the invention

The purpose, intention and contribution of the invention are realized by adopting the working steps of the following technical scheme.

2.1 base structure

The invention relates to a quantum magneto-optical multidimensional sensing method, which comprises the following working steps:

and for a detected object comprising specific protons in the detection area, a nuclear magnetic spectrum detection step, a scattered light spectrum detection step and a quantum magneto-optical multidimensional analysis step.

Specifically, the method includes but is not limited to:

s1000, a step: detecting nmr spectra, including but not limited to detection zones comprised of a main magnetic field, an excitation magnetic field, and a gradient magnetic field, for a particular proton, detecting nmr spectra by means including but not limited to electromagnetic induction.

S2000, a step: the spectrum of the scattered light is detected, including but not limited to, the spectrum of the scattered light is detected in nuclear magnetic resonance, in which the scattered light is generated by irradiating a detection point of the detection object with excitation light.

S3000, a step: quantum magneto-optical multidimensional analysis, including but not limited to nuclear magnetic spectrum and scattered light spectrum, calculates the detection content of specific protons or specific molecules including but not limited to specific protons in the detected object.

2.2, coordinates, states, emission angles and acceptance angles

On the basis of the foregoing basic solution, the present invention specifically includes but is not limited to the implementation of one or more of the following combinations:

s1010 step: a three-dimensional rectangular coordinate system is established by taking the main magnetic field direction as a Z axis, the direction perpendicular to the detection surface of the detected object as an X axis, the direction parallel to the detection surface as a Y axis and the inner end point of the detection area on the X axis as a coordinate origin. And the excitation magnetic field is arranged to be in the same direction as the X-axis or the Y-axis.

And S1020: the receiving angle is an angle between an optical axis of the scattered light and an X axis, and includes, but is not limited to, a projection angle of the receiving angle to the X axis as a receiving elevation angle and a projection angle of the receiving angle to the Y axis as a receiving azimuth angle.

And S1030: the light emission angle is an angle between the optical axis of the excitation light and the X-axis, and the light emission angle further includes, but is not limited to, a projection angle of the light emission angle to the X-axis as a light emission elevation angle and a projection angle of the light emission angle to the Y-axis as a light emission azimuth angle.

And S1040:

nuclear magnetic resonance includes, but is not limited to, a magnetization state and a resonance state and a relaxation state, wherein:

the magnetization state is a state in which only the main magnetic field is applied to the specimen and the excitation magnetic field and the gradient magnetic field are not applied thereto.

The resonance state is a state that the object is loaded with a main magnetic field, a gradient magnetic field and an excitation magnetic field, so that specific protons generate nuclear magnetic resonance.

The relaxation state is a state between when the detection object is in the resonance state, from the time when the excitation magnetic field is turned off until it is restored to the magnetization state.

The nmr spectrum includes, but is not limited to, electromagnetic induction signals in various states of nmr, including, but not limited to, free induction decay signals in a relaxation state, longitudinal relaxation time, transverse relaxation time, and electromagnetic induction signals at various state switching.

Step S2010: the excitation light includes, but is not limited to, a light beam of a specific wavelength irradiated in a focused or collimated manner to the detection point of the detection object, and the scattered light is a light beam scattered by the irradiation of the excitation light to the detection point of the detection object, and includes, but is not limited to, stokes scattered light, anti-stokes scattered light, brillouin scattered light, rayleigh scattered light, fluorescence.

S2020, a step: scattered light spectra include, but are not limited to, magnetization and resonance and relaxation spectra detected in the magnetization and resonance and relaxation states, and non-magnetic spectra detected in the non-magnetic state.

And S2030 step: and adjusting the light-emitting angle and the receiving angle to optimize the spectrum of the scattered light, wherein the light-emitting angle at the moment is the optimal light-emitting angle, and the receiving angle at the moment is the optimal receiving angle.

S2040: detecting the scattered light spectrum includes a scattered light sampling period including less than 2 times a period of nuclear magnetic resonance including a period of a magnetization state, a period of a resonance state, and a period of a relaxation state. The scattered light sampling period also includes, but is not limited to, periods greater than 2 times the nuclear magnetic resonance including, but not limited to, the period of the magnetization state, the period of the resonance state, and the period of the relaxation state.

2.3 gradient magnetic field

the gradient magnetic field working step of S1100 specifically includes, but is not limited to:

and S1110: the gradient magnetic field is arranged in the X-axis direction and is an X-gradient magnetic field, the main magnetic field and the X-gradient magnetic field are synthesized to form a synthesized magnetic field, and the magnetic field intensity of the synthesized magnetic field is in linear gradient distribution along the X-axis direction.

S1120: setting X-axis granularity according to linear gradient distribution, dividing the detected object into X-axis layers in an X-gradient magnetic field according to the X-axis granularity, taking the X-axis layer farthest from the origin of coordinates as the 1 st layer, and sequentially numbering the layers inwards.

And S1130: the gradient magnetic field is arranged in the Y-axis direction and is a Y-gradient magnetic field, the main magnetic field and the Y-gradient magnetic field are synthesized to form a synthesized magnetic field, and the magnetic field intensity of the synthesized magnetic field is linearly distributed in a gradient manner along the Y-axis direction.

And a step S1140: and setting Y-axis granularity according to linear gradient distribution, dividing the detected object into Y-axis layers in a Y-gradient magnetic field according to the Y-axis granularity, taking the Y-axis layer farthest from the origin of coordinates as the 1 st layer, and sequentially numbering the layers inwards.

S1150, step: the gradient magnetic field is arranged in the Z-axis direction and is a Z-gradient magnetic field, the main magnetic field and the Z-gradient magnetic field are synthesized to form a synthesized magnetic field, and the magnetic field intensity of the synthesized magnetic field is in linear gradient distribution along the Z-axis direction.

S1160, a step: and setting Z-axis granularity according to linear gradient distribution, dividing the detected object into Z-axis layers in a Z-gradient magnetic field according to the Z-axis granularity, taking the Z-axis layer farthest from the origin of coordinates as the 1 st layer, and numbering the layers inwards in sequence.

The strength of the gradient magnetic field is not greater than the strength of the main magnetic field.

2.4, 0-dimensional ensemble test

the step of detecting the whole 0-dimensional data in S4100 includes, but is not limited to:

s4110: the working steps of the 0-dimensional whole nuclear magnetic resonance specifically include but are not limited to:

s4120 step of turning off the gradient magnetic field and calculating the frequency of the excitation magnetic field of the entire specimen based on the specific protons and the magnetic field intensity of the main magnetic field.

S4130 step: and adjusting the frequency of the excitation magnetic field to be the frequency of the whole excitation magnetic field, and starting the excitation magnetic field to enable specific protons in the detected object to enter the whole nuclear magnetic resonance.

S4140 step: detecting the whole nuclear magnetic spectrum of the detected object, wherein the detection includes but is not limited to the whole nuclear magnetic spectrum of more than one pre-configured calibration objects known to contain specific protons or specific molecular content.

S4150 step: a detection point is provided on the surface of the object to be detected, and the surface scattered light spectrum of the object to be detected is detected, and the surface scattered light spectrum of the calibration object is detected.

S4160: setting a detection point on the surface of the detected object, detecting the surface scattering light spectrum of the detected object at the optimal light-emitting angle and the optimal receiving angle, and detecting the surface scattering light spectrum of the calibration object at the optimal light-emitting angle and the optimal receiving angle.

The detection depth of the scattered light spectrum is less than the maximum detection depth.

2.5, 1-dimensional layer detection

the 1-dimensional layer detection step of S4200 specifically includes, but is not limited to:

s4210: the 1-dimensional layer nuclear magnetic resonance working steps specifically include but are not limited to:

s4220 loads an X gradient magnetic field on the detection region, divides the detection region into one or more detection layers based on a composite magnetic field formed by the main magnetic field and the X gradient magnetic field for a specific proton, calculates the frequency of the layer excitation magnetic field and the thickness of the detection layer for all the detection layers, and calculates the maximum number of detection layers of the optical path through which scattered light can pass based on the attenuation of the excitation light and the scattered light in the detection layers.

S4230: and sequentially adjusting the frequency of the excitation magnetic field to be the frequency of the layer excitation magnetic field of all the detection layers, and sequentially starting the excitation magnetic field to enable specific protons in the detection layers to enter the nuclear magnetic resonance of the layers.

And S4240: the slice scan detects the slice nuclear magnetic spectrum of all detection slices.

And S4250: the detection point is arranged on the surface of the detected object, the surface scattering light spectrum of the detected object is detected, and the surface scattering light spectrum of the detected object at the optimal light-emitting angle and the optimal receiving angle is detected.

S4260: for the detected object of the living body with skin, the known skin thickness is less than the maximum detection thickness, the number of detection layers where the skin and the subcutaneous tissue are located is calculated, and the X gradient magnetic field is adjusted to detect the nuclear magnetic spectrum and the surface scattered light spectrum of the layers of the skin and the subcutaneous tissue.

S4270: the layer scattered light spectrum including the layer magnetization spectrum, the layer resonance spectrum, and the layer relaxation spectrum is calculated by subtracting the scattered light spectrum above and below the specified layer from the surface scattered light spectrum by a method including but not limited to a layer attenuation method, based on the surface scattered light spectrum including but not limited to the scattered light spectrum of all of the number of detected layers, from the layer nuclear magnetic resonance and the surface scattered light spectrum of the specified layer in the number of detected layers.

2.6, 2-dimensional strip detection

the 2-dimensional bar detection step of S4300 specifically includes, but is not limited to:

s4310: the 2-dimensional strip nuclear magnetic resonance working steps specifically include but are not limited to:

s4320, loading an X gradient magnetic field and a Y gradient magnetic field on the detection layer, dividing the detection layer into more than one detection strip according to a composite magnetic field formed by the main magnetic field, the X gradient magnetic field and the Y gradient magnetic field, calculating the frequency of the strip excitation magnetic field, and calculating the frequency of the strip excitation magnetic field of all the detection strips and the thickness of the detection strips aiming at specific protons.

S4330: and sequentially adjusting the frequency of the excitation magnetic field to be the frequency of the strip excitation magnetic field of all the detection strips, and sequentially starting the excitation magnetic field to enable specific protons in the detection strips to enter strip nuclear magnetic resonance.

S4340: the strip scan detects strip nuclear magnetic spectra of all the test strips.

S4350 step: and setting a detection point on the surface of the object to be detected of the detection strip along the X axis, detecting the surface scattered light spectrum, and calculating the strip scattered light spectrum according to the layer scattered light spectrum. And detecting the spectrum of the bar scattered light of the detected object at the optimal light emitting angle and the optimal receiving angle.

2.7, 3 dimensional bit detection

the 3-dimensional bit detection step of S4400 specifically includes but is not limited to:

s4410: the 3-dimensional nuclear magnetic resonance working steps specifically include but are not limited to:

and S4420, loading an X gradient magnetic field, a Y gradient magnetic field and a Z gradient magnetic field for the detection strip, dividing the detection strip into more than one detection position according to a combined magnetic field formed by the main magnetic field, the X gradient magnetic field, the Y gradient magnetic field and the Z gradient magnetic field aiming at specific protons, and calculating the frequency of bit excitation magnetic fields of all the detection positions and the width of the detection positions.

Step S4430: and sequentially adjusting the frequency of the excitation magnetic field to be the frequency of bit excitation magnetic fields of all detection bits, and sequentially starting the excitation magnetic field to enable specific protons in the detection bits to enter bit nuclear magnetic resonance.

S4440: the bit scan detects the bit nuclear magnetic spectrum of all detected bits.

S4450: a detection point is provided on the surface of the object to be detected at a detection position along the X-axis, a surface scattered light spectrum is detected, and a position scattered light spectrum is calculated from the layer scattered light spectrum. And detecting the bit scattered light spectrum of the detected object at the optimal light emitting angle and the optimal receiving angle.

2.8, 0-dimensional quantum magneto-optic multidimensional analysis

On the basis of the foregoing basic solution, the present invention specifically includes, but is not limited to, the step of implementing 0-dimensional quantum magneto-optical multidimensional resolution of S3100 by one or more combinations of the following, and specifically includes, but is not limited to:

step S3110: steps S4110 to S4160 are performed to obtain the bulk nmr spectrum and the surface scattered light spectrum of the detection object and the calibration object.

S3120: establishing a comparison database according to the content of the specific protons or the specific molecules included in the calibration object but not limited to and the obtained whole nuclear magnetic spectrum and surface scattering optical spectrum, wherein the comparison database at least comprises but not limited to specific proton names, specific molecule names, contents, whole nuclear magnetic spectrum, surface scattering optical spectrum, surface magnetization spectrum, surface resonance spectrum, surface relaxation spectrum and surface non-magnetic optical spectrum, and optimizing the light-emitting angle and the receiving angle.

S3130: and comparing and searching in a comparison database according to the surface magnetization spectrum, the surface resonance spectrum, the surface relaxation spectrum and the surface non-magnetic spectrum in the integral nuclear magnetic spectrum and the surface scattered light spectrum of the detected object, finding out the content of the closest calibration object, and calculating the detection content of the specific proton or the specific molecule in the detected object by adopting an interpolation method, a regression analysis method, a BP network method or a neural network method.

2.9, 1-dimensional quantum magneto-optic multidimensional analysis

On the basis of the foregoing basic scheme, the present invention specifically includes but is not limited to one or more of the following implementations in combination, specifically: the 1-dimensional quantum magneto-optical multidimensional analysis method of the S3200 specifically includes, but is not limited to:

step S3210: steps S4210 to S4270 are performed to acquire layer nuclear magnetic spectra and layer scattered light spectra of all layers in the maximum number of detection layers.

And S3220: and comparing and searching in a comparison database according to the layer magnetization spectrum, the layer resonance spectrum, the layer relaxation spectrum and the layer non-magnetic spectrum in the layer nuclear magnetic spectrum and the layer scattering light spectrum of the detected object, finding out the content of the closest calibration object, and calculating the detection content of the specific proton or the specific molecule of the specified layer in the detected object by adopting an interpolation method, a regression analysis method, a BP network method or a neural network method.

2.10, 2-dimensional quantum magneto-optical multidimensional analysis

On the basis of the foregoing basic solution, the present invention specifically includes, but is not limited to, the following extremum calculation, specifically:

the step of multidimensional 2-dimensional quantum magneto-optical resolution of the S3300 specifically includes, but is not limited to:

s3310 step: and executing steps S4310 to S4350 to obtain the strip nuclear magnetic spectrum and the strip scattered light spectrum of all the detection layers with the maximum detection layer number.

And S3320: and comparing and searching in a comparison database according to the strip nuclear magnetic spectrum and the strip scattered light spectrum of all the detection strips, finding out the content of the closest calibration object, and calculating the detection content of the specific proton or the specific molecule of the specified strip in the detection object by adopting an interpolation method, a regression analysis method, a BP network method or a neural network method. Or the like, or, alternatively,

and S3330: and calculating the detection content of the specific proton or the specific molecule of the specified strip in the detection object by using a weighted average method, a regression analysis method and a convolution neural network algorithm according to the strip nuclear magnetic spectrum and the strip scattered light spectrum of all the detection strips.

2.11, 3-dimensional quantum magneto-optic multidimensional analysis

the 3-dimensional quantum magneto-optical multidimensional analysis method of the S3400 specifically includes, but is not limited to:

s3410 step: steps S4410 to S4450 are performed to acquire bit nuclear magnetic spectra and bit scattered light spectra of all detection bits on all detection strips in all detection layers up to the number of detection layers.

Step S3420: and comparing and searching in a comparison database according to the bit nuclear magnetic spectrum and the bit scattered light spectrum of all the detection bits to find out the content of the closest calibration object, and calculating the detection content of the specific proton or the specific molecule of the designated position in the detection object by adopting an interpolation method, a regression analysis method, a BP network method or a neural network method. Or the like, or, alternatively,

step S3430: and calculating the detection content of the specific proton or the specific molecule of the designated position in the detected object by adopting a weighted average method, a regression analysis method and a convolution neural network algorithm according to the bit nuclear magnetic spectrum and the bit scattered light spectrum of all the detection bits.

2.12, other calculations

The step of S3500 specifically includes but is not limited to:

s3510: and searching analysis abnormal data according to the time change data of the nuclear magnetic spectrum and the scattered light spectrum of the calibration object and the detection object during the conversion of the nuclear magnetic resonance state, and calculating the detection content of specific protons or specific molecules of specified positions in the detection object by adopting a weighted average method, a regression analysis method and a convolution neural network algorithm.

S3550 step: and (4) according to the detection content of all detection layers or detection strips or detection positions, arranging according to a right-angle three-dimensional coordinate system of an X axis, a Y axis and a Z axis, and calculating and displaying an image.

2.13 advantageous effects of the invention

(1) Qualitative correlations of nuclear magnetic resonance states with scattered light spectra in multiple spatial dimensions are established.

(2) And establishing an analytical method of magnetic spectrum and optical spectrum on multiple spatial dimensions.

(3) An embodiment based on noninvasive broad-spectrum detection of human skin, such as an noninvasive glucose meter, is designed.

(4) And the technology of nuclear magnetic resonance and scattered light spectrum is integrated, so that the manufacturing cost is reduced.

Drawings

FIG. 1: schematic diagram

In FIG. 1, the main magnetic field B is formed by a strong longitudinal magnetic field ₀ The gradient magnetic field and the radio frequency magnetic field are arranged in the transverse direction, and the object to be detected is arranged in the main magnetic field, wherein, taking a human finger as the object to be detected, from right to left, the object to be detected is respectively the epidermis layer L ₁ And a subcutaneous tissue layer L ₂ Capillary layer L ₃ And the like. The excitation light is irradiated to a certain point (detection point) of the finger, and for convenience of explanation, the present invention is applied to the decomposition of the excitation light into EL ₁ 、EL ₂ 、EL ₃ However, EL ₁ 、EL ₂ 、EL ₃ Are combined into a beam of light. The excitation light gradually attenuates after penetrating into the skin and reaches the epidermal layer L ₁ And the subcutaneous tissue layer L ₂ Capillary layer L ₃ Respectively generate scattered lights CL ₁ 、CL ₂ 、CL ₃ . At the detection point, scattered light is collected at an angle of a certain numerical aperture.

FIG. 2 is a schematic diagram: principle diagram of quantum scattering light

In fig. 2, 201 denotes an excitation light direction axis. 202 is the excitation light photon. 203 is the directional axis of the scattered light. 204 are scattered light photons. 205 is the ground state energy level. 206 is the virtual state energy level. 207 is the last state energy level. 208 is an electron at the ground state energy level. 209 is an electron at the virtual state energy level. 210 are electrons that move to a position at the virtual energy level. 211 is an electron moving to the end state energy level, and 212 is a nucleus. The movement process is that the excitation light photon hits the electron in the ground state level at 208, the electron absorbs the energy of the photon, the energy level transitions to the electron 209 in the high level in the virtual state level 206, the electron moves to some point, for example 210, and releases a photon 204, called scattered light photon, which moves in the direction of 203, 203 becomes the directional axis of the scattered light, and the electron loses part of its energy and falls back to the end state level, 211. According to the principle of conservation of energy, the electron energy of the end state energy level is slightly larger than that of the ground state energy level, so the energy of the scattered light photon is also slightly smaller than that of the excitation light photon, i.e. the wavelength of the scattered light is slightly longer than that of the excitation light. This is the quantum process that scattered light produces.

FIG. 3: scattered light thorn ball model diagram

Fig. 3 is a diagram of the quantum scattered light principle according to fig. 2, which is a model of the statistical distribution over a long period of time of a single atom. Where 301 is an atom, 302 is a scattered light photon statistical distribution at the point irradiated with the excitation light, 303 is a scattered light probability distribution of the circular hill model, and 304 is a scattered light distribution showing a single peak shape. Refer to the invention patent application of the quantum scattering light distribution detector based on multi-axis and multi-mode in detail as 'China patent application No. 202210270064.4'.

FIG. 4: nuclear magnetic state diagram

In FIG. 4, the abscissa T is the time axis and the ordinate H is the magnetic field axis, where B ₀ Is the magnetic field strength of the main magnetic field, B _ωx Is the magnetic field strength, t, of the exciting radio frequency magnetic field ₀ To t ₁ In a non-magnetic state, t ₁ To t ₂ Is a magnetization state, t ₂ To t ₃ Is a resonance state, t ₃ To t ₄ Is in a relaxed state.

FIG. 5: one-dimensional layer detection map

Fig. 5 is a state layout diagram of one-dimensional based detection layers. Wherein 501 and 502 are two poles constituting a main magnetic field; 503 and 504 are coils that generate X-axis gradient magnetic fields; 505 is a radio frequency coil that generates an excitation radio frequency magnetic field; 506 is an induction coil for detecting a magnetic field; 507 is a detection object, such as a finger; 508 is an excitation light generation module; 509 is a scattered light receiving module; and 510 is a detection point.

FIG. 6: excitation light generation module diagram

Fig. 6 is a structural view of the excitation light generation module, in which 601 and 609 are optical axes of the excitation light; 602 is a detection point, which is also a point irradiated by the excitation light focusing or collimating; 603 is the main structure of the exciting light generating module; 604 and 606 are condenser lenses; 605 is a narrow band filter; 607 is a light emitting tube of excitation light, such as a laser; 608 is the interface circuit of the excitation light generation module.

FIG. 7 is a schematic view of: scattered light receiving module diagram

Fig. 7 is a structural diagram of a scattered light receiving module, in which 701 and 708 are optical axes of a scattered light receiving optical path; 702 is a detection point and also is a focus of a numerical aperture in the scattered light receiving module; 703 is the main structure of the scattered light receiving module; 704 and 706 are condenser lenses; 705 is a filter lens, and the classification and the requirements of the filter lens in the Chinese patent application No. 202210270064.4 of the quantum scattered light distribution detector based on multi-axis and multi-mode are referred to herein; 707 is an optical fiber, and it is recommended to use an optical fiber having a large core diameter (e.g., 200 μm in diameter).

FIG. 8: three-dimensional position detection map

In FIG. 8, X, Y, and Z are three-dimensional rectangular coordinates, L ₁ 、L ₂ 、L ₃ Three detection layers, B ₁ 、B ₂ 、B ₃ Three test strips respectively, the middle black cube is a volume element, namely a test position, and the exciting light is emitted from L ₁ Enter L ₂ And the generated scattered light is collected by the scattered light module. Wherein, the voxel in the figure is composed of L ₂ And B ₂ And (4) positioning.

Detailed Description

The purpose, intention and contribution of the invention are realized by the following technical scheme of 2 embodiments. It is specifically noted that each of the specific embodiments has specific applications and industrial applicability. Accordingly, none of the following examples include all of the features and steps of the present invention and are not intended to limit the invention, which is defined by the claims appended hereto.

Example one, method of three-dimensional subcutaneous specific molecular distribution imaging

1. Brief description and drawings

This embodiment is a full version of the invention. The content distribution of subcutaneous specific molecules can be detected and imaged in three dimensions. The precision of the imaging size is the volume element size of nuclear magnetic resonance and the detection point area and depth size of scattered light spectrum.

For the views, refer to fig. 1 to 8.

2. Protocol and procedure

2.1, base Structure

Specifically, the method includes but is not limited to:

s1000, step: detecting nmr spectra, including but not limited to detection zones comprised of a main magnetic field, an excitation magnetic field, and a gradient magnetic field, for a particular proton, detecting nmr spectra by means including but not limited to electromagnetic induction.

S2000, step: the spectrum of the scattered light is detected, including but not limited to, the spectrum of the scattered light is detected in nuclear magnetic resonance, in which the detection point of the detection object is irradiated with excitation light to generate scattered light.

Generally, the specific proton of the more effective detector is a hydrogen proton as nuclear magnetic resonance. Thus, as a specific example, the patent will refer to hydrogen protons ¹ H) As a particular proton of primary nuclear magnetic resonance detection, but other protons are not excluded here, e.g. ¹³ C、 ¹⁵ N、 ¹⁹ F、 ²⁹ Si、 ⁷ Li、 ⁹ Be, etc. The specific molecule is a compound molecule including a specific proton, such as glucose (C) ₆ H ₁₂ O ₆ ) Or sodium chloride (NaCL) or progesterone (C) ₂₁ H ₃₀ O ₂ ) And the like.

In fact, based on the basic principle of the present application, this sensing method is a general method based on noninvasive broad-spectrum IVD for living organisms.

2.2 coordinates, states, emission angles and acceptance angles

On the basis of the foregoing basic scheme, the present invention specifically includes but is not limited to one or more of the following implementation combinations:

s1010 step: and establishing a three-dimensional rectangular coordinate system by taking the main magnetic field direction as a Z axis, the direction perpendicular to the detection surface of the detected object as an X axis, the direction parallel to the detection surface as a Y axis and the inner end point of the detection area on the X axis as a coordinate origin. And the excitation magnetic field is arranged to be in the same direction as the X-axis or the Y-axis.

And S1030 step: the light emission angle is an angle between the optical axis of the excitation light and the X-axis, and the light emission angle further includes, but is not limited to, a projection angle of the light emission angle to the X-axis as a light emission elevation angle and a projection angle of the light emission angle to the Y-axis as a light emission azimuth angle.

And S1040:

The relaxation state is a state between when the detection object is in the resonance state, starting from turning off the excitation magnetic field until returning to the magnetization state.

Step S2010: the excitation light includes, but is not limited to, a light beam of a specific wavelength that is irradiated in a focused or collimated manner to a detection point of the detection object, and the scattered light is a light beam that is scattered due to the irradiation of the excitation light to the detection point of the detection object, and includes, but is not limited to, stokes scattered light, anti-stokes scattered light, brillouin scattered light, rayleigh scattered light, and fluorescence.

S2020, step: scattered light spectra include, but are not limited to, magnetization and resonance and relaxation spectra detected in the magnetization and resonance and relaxation states, and non-magnetic spectra detected in the non-magnetic state.

And S2030 step: and adjusting the light emitting angle and the receiving angle to optimize the spectrum of the scattered light, wherein the light emitting angle at the moment is the optimal light emitting angle, and the receiving angle at the moment is the optimal receiving angle.

S2040: detecting the spectrum of scattered light includes a scattered light sampling period that includes less than 2 times a period of nuclear magnetic resonance including a period of a magnetization state, a period of a resonance state, and a period of a relaxation state. The scattered light sampling period also includes, but is not limited to, a period of nuclear magnetic resonance greater than 2 times, including, but not limited to, a period of a magnetization state, a period of a resonance state, and a period of a relaxation state.

It is particularly noted here that, as a conventional nuclear magnetic resonance apparatus, the pulse width of the excitation magnetic field is very short, and the intensity of the excitation magnetic field is also very strong, for example, the power is two steps of kilowatt to several tens of kilowatt. In the present invention, the pulse width of the excitation magnetic field needs to be sufficient to support the collection of the spectrum of the scattered light, that is, the pulse width of the excitation magnetic field needs to be more than 2 times larger than the sampling period of the scattered light. In addition, the energy level of the excitation magnetic field should be adjusted as the overall mass of the test object changes. It should be reminded that when the invention is used for human body detection, the pulse energy of the excitation magnetic field must not generate discomfort for human body, and the recommended power is within kilowatt.

With respect to the illumination angle and the acceptance angle, if the present invention is used in a dedicated detection device (e.g., a human IVD for detecting glucose in blood), the illumination angle and the acceptance angle can be fixed using optimized empirical values, i.e., the illumination angle and the acceptance angle are fixed, to reduce the complexity and cost of the device. In addition, for similar application scenarios, the 3-dimensional detection of the present invention can be simplified to 1-dimensional detection, i.e. only layering is needed, e.g. for finger and skin detection, only the skin is removed and the subcutaneous tissue is detected.

The illumination and reception angles are further subdivided into elevation and azimuth angles because there are different subdivision angles in different magnetic field environments and detection applications.

Regarding the sampling period of the scattered light, those skilled in the art should be reminded that different adjustments can be made at different detection stages, and the sampling period of the scattered light is not fixed.

2.3 gradient magnetic field

s1110: the gradient magnetic field is arranged in the X-axis direction and is an X-gradient magnetic field, the main magnetic field and the X-gradient magnetic field are synthesized to form a synthesized magnetic field, and the magnetic field intensity of the synthesized magnetic field is in linear gradient distribution along the X-axis direction.

S1120: setting X-axis granularity according to linear gradient distribution, dividing a detected object into X-axis layers according to the X-axis granularity in an X-gradient magnetic field, taking the X-axis layer farthest from the origin of coordinates as a 1 st layer, and numbering the layers inwards in sequence.

S1160 step: and setting Z-axis granularity according to linear gradient distribution, dividing the detected object into Z-axis layers in a Z-gradient magnetic field according to the Z-axis granularity, taking the Z-axis layer farthest from the origin of coordinates as the 1 st layer, and sequentially numbering the layers inwards.

The strength of the gradient magnetic field is no greater than the strength of the main magnetic field.

Regarding the gradient magnetic field, in some applications, it can be simplified to only one-dimensional detection, for example, for the detection of glucose in vitro of human body, only the X-axis gradient magnetic field, no Y-axis gradient magnetic field and no Z-axis gradient magnetic field are needed, and only layered detection is needed.

For the in-vitro glucose detection of a human body, attention needs to be paid to finding a skin layer during layer detection, thickness calculation of an X-axis gradient magnetic field is carried out according to the skin thickness, and during subsequent calculation, fingerprint spectrum signals of glucose molecules in the skin layer are removed, so that only the content of glucose in subcutaneous tissues needs to be calculated.

The reason why the gradient magnetic field needs to be numbered is that in scattered light spectrum detection, the depth of irradiation of an excitation light to a detection object (for example, the skin of the finger abdomen of a human finger) is generally limited, and in nuclear magnetic resonance layered detection, the depth of irradiation of the excitation light is generally several mm, while the layer thickness of nuclear magnetic resonance is generally in the order of mm, and therefore, when scattered light spectrum and nuclear magnetic spectrum are correlated, the number of layers is generally about two or three.

2.4, 0-dimensional Overall detection

the step of detecting the 0-dimensional whole body in S4100 includes, but is not limited to:

S4130: and adjusting the frequency of the excitation magnetic field to be the frequency of the whole excitation magnetic field, and starting the excitation magnetic field to enable specific protons in the detected object to enter the whole nuclear magnetic resonance.

S4150 step: a detection point is provided on the surface of a test object, and the surface scattered light spectrum of the test object is detected, and the surface scattered light spectrum of a calibration object is detected.

S4160 step: setting a detection point on the surface of the detected object, detecting the surface scattered light spectrum of the detected object at the optimal light-emitting angle and the optimal receiving angle, and detecting the surface scattered light spectrum of the calibration object at the optimal light-emitting angle and the optimal receiving angle.

The scattered light spectrum has a detection depth less than the maximum detection depth.

The 0-dimensional detection is actually the detection of the whole detection object as a whole, and the detection of non-layering, non-striping and non-dividing positions.

The calibration object is mainly used for manufacturing the efficacy of a standard metering weight when the invention is applied for the first time. A set of standards for concentration gradients of known concentration may be pre-configured, detected and recorded as standards for later use. In this case, the calibrant may be selected from an aqueous solution of the pure substance or other solutions.

Due to the action of the magnetic field, specific protons are in the magnetic field, and are magnetized by the static magnetic field, and the excitation magnetic field causes resonance, attenuation during relaxation, and even in the case of a non-magnetic state when the main magnetic field is turned off, the precession and nutation of the specific protons are different, thereby causing the positions and angles of the scattered light photons to be generated to be different. Therefore, an equation system of quantum motion linkage of the magnetic spectrum of the nuclear magnetic resonance and the spectrum of the scattered light can be established for further solving.

For the parameters and calculation of nuclear magnetic spectrum and scattered light spectrum, those skilled in the art should perform correlation calculation according to basic knowledge. For example, for subcutaneous tissue, different tissue types, longitudinal relaxation time T in NMR ₁ And transverse relaxation time T ₂ Is different, e.g. T for blood at a field strength of the main magnetic field of 1.0T ₁ And T ₂ 800ms and 180ms, respectively; for muscle, T ₁ And T ₂ 600ms and 40ms, respectively; for fat, T ₁ And T ₂ Respectively 180ms and 90ms.

2.5, 1-dimensional layer detection

the 1-dimensional layer detection step of S4200 includes, but is not limited to:

and a step S4220 of loading an X gradient magnetic field on the detection region, dividing the detection region into at least one detection layer according to a combined magnetic field formed by the main magnetic field and the X gradient magnetic field for specific protons, calculating the frequency of a layer excitation magnetic field and the thickness of the detection layer for all the detection layers, and calculating the maximum number of detection layers of an optical path through which scattered light can pass based on the attenuation of the excitation light and the scattered light in the detection layers.

S4230: and sequentially adjusting the frequency of the excitation magnetic field to be the frequency of the layer excitation magnetic field of all the detection layers, and sequentially starting the excitation magnetic field to enable specific protons in the detection layers to enter layer nuclear magnetic resonance.

S4250: a detection point is arranged on the surface of the detected object, the surface scattered light spectrum of the detected object is detected, and the surface scattered light spectrum of the detected object at the optimal light-emitting angle and the optimal receiving angle is detected.

S4260: for the detected object of the living body with skin, the known skin thickness is less than the maximum detection thickness, the number of detection layers where the skin and the subcutaneous tissue are located is calculated, and the X gradient magnetic field is adjusted to detect the nuclear magnetic spectrum and the surface scattering light spectrum of the layers of the skin and the subcutaneous tissue.

And S4270: the layer scattered light spectrum including the layer magnetization spectrum, the layer resonance spectrum, and the layer relaxation spectrum is calculated by subtracting the scattered light spectrum above and below the specified layer from the surface scattered light spectrum by a method including but not limited to a layer attenuation method, based on the surface scattered light spectrum including but not limited to the scattered light spectrum of all of the number of detected layers, from the layer nuclear magnetic resonance and the surface scattered light spectrum of the specified layer in the number of detected layers.

Along with the property difference of the detection object, when the excitation light irradiates the detection point of the detection object, the excitation light can enter the detection object to a certain depth along the optical axis of the excitation light in a gradient attenuation mode along with the difference of the wavelength of the excitation light and the property of the detection object. When infrared laser with the wavelength of 785nm and 1064nm is used as the excitation light, the infrared laser can enter the skin of a human body by about 2mm to 3.5mm, and the excitation light gradually attenuates with the change of the depth. The scattered light produced also fades away with increasing depth. In this patent application we will correct the intensity of the scattered light for the detection layer according to the linear attenuation.

It should be noted that, although there is no problem of detection depth in terms of nuclear magnetic resonance, the depth of the detection layer must be adapted to the depth of the excitation light entering the detection object due to the depth limit of the excitation light entering the detection object, otherwise, the combined solution of the magnetic spectrum and the optical spectrum cannot be realized.

It should be noted that for the case where imaging is not required and only subcutaneous tissue detection is required, only 1-dimensional layer detection is required here.

2.6, 2-dimensional strip detection

the 2-dimensional bar detection step of S4300 specifically includes but is not limited to:

S4350: and setting a detection point on the surface of the object to be detected of the detection strip along the X axis, detecting the surface scattered light spectrum, and calculating the strip scattered light spectrum according to the layer scattered light spectrum. And detecting the bar scattered light spectrum of the detected object at the optimal light emitting angle and the optimal receiving angle.

The test strip is introduced to further enhance the positioning of the test point. It should be noted that the detection point must correspond to the position of the test strip, i.e. the detection point must be located on the detection plane of the test strip along the X-axis.

As a specific implementation method of the detection strip scanning, in this embodiment, the excitation light generation module and the scattered light collection module are designed to be a fixed structure, and then a stepping motor controller that moves linearly along the X axis is designed, so that the detection point can move along with the position change of the detection strip.

In the case of a disturbance such as a scar on the skin, the introduction of 2-dimensional strip detection can skip the scar to allow the detection site to be at the normal skin site or to be directed at the subcutaneous blood vessel for detection.

2.7, 3 dimensional bit detection

S4450: a detection point is provided on the surface of the object to be detected at the detection position along the X-axis, the spectrum of surface scattered light is detected, and the spectrum of bit scattered light is calculated from the spectrum of layer scattered light. And detecting the bit scattered light spectrum of the detected object at the optimal light emitting angle and the optimal receiving angle.

Detection bits are in the field of nuclear magnetic resonance, and the customary term is also called "voxel". The detection position is introduced to further strengthen the positioning of the detection point. It should be noted that the detection point must be in line with the position of the detection site, i.e. the detection point must be at the position of the detection plane of the detection site along the X-axis.

As a specific implementation method of the strip scanning and the detection position scanning, in this embodiment, the excitation light generation module and the scattered light collection module are designed to be a fixed structure, and then a stepping motor controller that performs planar motion along the X axis and the Y axis is designed, so that the detection point can move along with the position change of the detection strip and the detection position.

In the case of a scar or other disturbance on the skin, the 3-dimensional site detection can be introduced by skipping the scar or other disturbance so that the detection site is at the normal skin or aiming at the subcutaneous blood vessel for detection.

2.8, 0-dimensional quantum magneto-optical multidimensional analysis

On the basis of the foregoing basic solution, the invention specifically includes, but is not limited to, the step of 0-dimensional quantum magneto-optical multidimensional resolution of S3100 implemented by one or more combinations of the following, and specifically includes, but is not limited to:

Step S3130: and comparing and searching in a comparison database according to the surface magnetization spectrum, the surface resonance spectrum, the surface relaxation spectrum and the surface non-magnetic spectrum in the integral nuclear magnetic spectrum and the surface scattering light spectrum of the detected object, finding out the content of the closest calibration object, and calculating the detection content of the specific proton or the specific molecule in the detected object by adopting an interpolation method, a regression analysis method, a BP network method or a neural network method.

The 0-dimension here means that the whole detection object is taken as a whole and is not further distinguished.

For the application of the in vitro noninvasive glucose detection of the human body, the other working step of the calibration object is to detect the blood drawn from the human body vein in a biochemical analyzer, obtain a glucose value as a known glucose value of the calibration object, compare the data of the whole nuclear magnetic spectrum and the surface scattering light spectrum detected in the step, use the glucose value tested by the biochemical analyzer as comparison data to calibrate the detection content calculated in the step, and establish a comparison database. And obtaining comparison data of the comparison database through multiple experiments of multi-glucose value detection.

For other subcutaneous molecular assays, e.g. glucose (C) ₆ H ₁₂ O ₆ ) Or sodium chloride (NaCL) or progesterone (C) ₂₁ H ₃₀ O ₂ ) And the standard substance needs to select standard content of progesterone, and a comparison database is detected and established.

2.9, 1-dimensional quantum magneto-optic multidimensional analysis

On the basis of the foregoing basic scheme, the present invention specifically includes but is not limited to one or more of the following implementations in combination, specifically: the 1-dimensional quantum magneto-optical multidimensional analysis step of S3200 specifically includes, but is not limited to:

Step S3220: and comparing and searching in a comparison database according to the layer magnetization spectrum, the layer resonance spectrum, the layer relaxation spectrum and the layer non-magnetic spectrum in the layer nuclear magnetic spectrum and the layer scattering light spectrum of the detected object, finding out the content of the closest calibration object, and calculating the detection content of the specific proton or the specific molecule of the specified layer in the detected object by adopting an interpolation method, a regression analysis method, a BP network method or a neural network method.

The 1-dimensional detection means that the whole detection object is divided into a plurality of detection layers, and further detection is carried out on each detection layer.

The maximum number of detection layers is calculated based on the depth at which excitation light can enter a test object (e.g., skin), for example, the maximum depth of about 3.0mm in the skin of the finger pulp of a human finger for a laser light having a wavelength of 785nm, and the depth of the epidermis and dermis in the skin is about 1.2mm, and for the detection of glucose, it is necessary to perform in the subcutaneous tissue below the dermis, and thus nuclear magnetic spectrum and scattered light spectrum data of the detection layer in the range of 1.2mm to 3.0mm are calculated. Specifically, in the layered calculation in the gradient magnetic field during nuclear magnetic resonance, for example, the voxel size here is 1.40mm, then the thickness of the first layer of voxels is 1.4mm, which is exactly the tissue of epidermis and dermis, and we do not need to detect the glucose value here, while the layer of the second layer of voxels is between 1.4mm and 2.8mm, which is exactly the position where we need to detect glucose, so the excitation magnetic field frequency of the layer is calculated, and according to this frequency, the tissue of 1.4mm to 2.8mm under the finger skin is brought into the hydrogen nuclear magnetic resonance state, according to the scattered light spectrum obtained under this nuclear magnetic resonance state, the scattered light attenuation of the first layer (1.4 mm) is subtracted, so as to obtain the scattered light spectrum signal of the detection layer, and according to the comparison database, the detected content of glucose, which is a specific molecule, is found and calculated.

2.10, 2-dimensional quantum magneto-optical multidimensional analysis

On the basis of the foregoing basic scheme, the present invention specifically includes, but is not limited to, the following extremum calculation, specifically:

And S3320: and comparing and searching in a comparison database according to the strip nuclear magnetic spectrum and the strip scattered light spectrum of all the detection strips to find out the content of the closest calibration object, and calculating the detection content of the specific proton or the specific molecule of the specified strip in the detection object by adopting an interpolation method, a regression analysis method, a BP network method or a neural network method. Or the like, or, alternatively,

The 2-dimensional detection method is characterized in that the whole detection object is divided into a plurality of detection layers, the detection layers are divided into a plurality of detection strips, and further detection is carried out on each detection layer and each detection strip.

Based on the step S4350, the positions of the detection point and the detection strip need to be coincident, so the spectrum detection device can be designed to be movable, and further, can be designed to be an automatic linkage device of the detection strip and the detection point.

For the detection of the detection layer therein and the determination of the size of the detection layer, the steps are as described above.

2.11, 3-dimensional quantum magneto-optic multidimensional analysis

Step S3420: and comparing and searching in a comparison database according to the bit nuclear magnetic spectrum and the bit scattered light spectrum of all the detection bits to find out the content of the closest calibration object, and calculating the detection content of the specific proton or the specific molecule of the designated position in the detection object by adopting an interpolation method, a regression analysis method, a BP network method or a neural network method. Or the like, or a combination thereof,

The 3-dimensional detection method is characterized in that the whole detection object is divided into a plurality of detection layers, the detection layers are divided into a plurality of detection strips, the detection strips are divided into a plurality of detection positions, and each detection layer, each detection strip and each detection position are further detected.

Furthermore, the device for the planar scanning positioning of the X-Y axis is designed by the device for the excitation light and the scattered light.

2.12, other calculations

the step of S3500 specifically includes but is not limited to:

s3510 step: and searching analysis abnormal data according to the time change data of the nuclear magnetic spectrum and the scattered light spectrum of the calibration object and the detection object during the conversion of the nuclear magnetic resonance state, and calculating the detection content of specific protons or specific molecules of specified positions in the detection object by adopting a weighted average method, a regression analysis method and a convolution neural network algorithm.

The abnormal data here mainly refers to data of nuclear magnetic spectrum and scattered light spectrum obtained when the nuclear magnetic resonance state changes. For example, when the magnetic field strength of the main magnetic field is increased or decreased, when the magnetic field strength of the gradient magnetic field is close to the main magnetic field, and when the nuclear magnetic resonance state is switched, in the change, the nuclear magnetic spectrum and the scattered light spectrum are different due to the fact that specific protons have different covalent bond structures in different specific molecules.

The images include a nuclear magnetic spectrum image and a static image of a scattered light spectrum, and the nuclear magnetic spectrum and the scattered light spectrum can be fused into a static image. Furthermore, the image can be dyed, and further, a dynamic image of the video can be formed according to the time data.

S3560 step: layer attenuation methods include, but are not limited to, determining an attenuation gradient as a function of excitation light wavelength properties and detector properties.

Example two, IVD assay method for noninvasive glucose and progesterone

1. Brief introduction to the drawings

Unlike the first embodiment, this embodiment is not used as an imaging and its performing in vitro detection in an image manner, but is an embodiment of a low-cost human IVD detection method. Those skilled in the art should be able to construct a low cost human IVD, such as an apparatus for detecting glucose, in accordance with this method.

2. Description of the figures

The structure of the present embodiment is schematically shown in fig. 1, 5, 6 and 7. It should be understood by those skilled in the art that these drawings are merely schematic illustrations and are not intended to limit the present embodiments.

3. Description of differentiation

The same points as the first embodiment are not repeated here, and as illustrated in the previous drawings, the differences are:

1. detection and analysis of the detection strip and the detection position are cancelled, and the monitoring method is simplified;

2. an imaging is cancelled to display the detection result, and the detection data is directly given.

Claims

1. The quantum magneto-optical multidimensional sensing method is characterized by comprising the following steps: for a detected object comprising a specific proton in a detection area, a nuclear magnetic spectrum detection step, a scattered light spectrum detection step and a quantum magneto-optical multidimensional analysis step specifically comprise the following steps:

s1000, step: detecting the nuclear magnetic spectrum, wherein the nuclear magnetic spectrum comprises a detection area consisting of a main magnetic field, an excitation magnetic field and a gradient magnetic field, nuclear magnetic resonance is formed for specific protons, 0-3-dimensional space detection is formed by adjusting the gradient magnetic field, and the nuclear magnetic spectrum is detected in an electromagnetic induction mode;

s2000, step: detecting the scattered light spectrum, wherein the detection point of the detection object is irradiated by exciting light to generate scattered light, the 0-3-dimensional scattered light spectrum is detected while the 0-3-dimensional nuclear magnetic spectrum is detected, and the layered scattered light spectrum is calculated and analyzed according to a layering theory and a scattered light attenuation algorithm; s3000, a step: the quantum magneto-optical multidimensional analysis comprises the steps of calculating the detection content of specific protons or specific molecules including the specific protons in a detected object by adopting the nuclear magnetic spectrum and the layered scattered light spectrum;

further comprising:

establishing a three-dimensional rectangular coordinate system in the main magnetic field direction, the direction perpendicular to the detection surface of the detected object and the direction parallel to the detection surface, and arranging the excitation magnetic field in the same direction as the direction perpendicular to the detection surface of the detected object or the direction parallel to the detection surface; the gradient magnetic field can be arranged in any one of the same directions of the three-dimensional rectangular coordinate system.

2. The method of claim 1, further comprising:

s1010 step: establishing a three-dimensional rectangular coordinate system by taking the direction of the main magnetic field as a Z axis, the direction perpendicular to the detection surface of the detected object as an X axis, the direction parallel to the detection surface as a Y axis and the inner end point of the detection area on the X axis as a coordinate origin, and arranging the excitation magnetic field to be in the same direction as the X axis or the Y axis; the gradient magnetic field can be arranged in the X-axis direction or the Y-axis direction or the Z-axis direction;

and S1020: the receiving angle is an included angle between an optical axis of the scattered light and an X axis, and the receiving angle also comprises a receiving elevation angle which is a projection angle of the receiving angle to the X axis and a receiving azimuth angle which is a projection angle of the receiving angle to a Y axis;

and S1030 step: the light-emitting angle is an included angle between the optical axis of the exciting light and the X axis, and the light-emitting angle also comprises a projection angle of the light-emitting angle to the X axis as a light-emitting elevation angle and a projection angle of the light-emitting angle to the Y axis as a light-emitting azimuth angle;

and S1040:

nuclear magnetic resonance includes a magnetization state and a resonance state and a relaxation state, in which,

the magnetization state is a state in which the object to be detected is loaded with only the main magnetic field and is not loaded with the excitation magnetic field and the gradient magnetic field,

the resonance state is a state that the object is loaded with the main magnetic field, the gradient magnetic field and the excitation magnetic field, so that specific protons generate nuclear magnetic resonance,

the relaxation state is a state between the state that the detection object is switched off from the excitation magnetic field until the detection object is restored to the magnetization state when the detection object is in the resonance state, and the nuclear magnetic spectrum comprises electromagnetic induction signals in the nuclear magnetic resonance state, free induction decay signals in the relaxation state, longitudinal relaxation time and transverse relaxation time, and electromagnetic induction signals when the state is switched;

step S2010: the excitation light comprises a light beam with a specific wavelength and is irradiated to a detection point of the detection object in a focusing or collimating way, and the scattered light is a light beam which is scattered due to the irradiation of the excitation light to the detection point of the detection object and comprises Stokes scattered light, anti-Stokes scattered light, brillouin scattered light, rayleigh scattered light and fluorescence;

s2020, a step: the scattered light spectrum includes a magnetization spectrum and a resonance spectrum and a relaxation spectrum detected in a magnetization state and a resonance state and a relaxation state, and further includes a non-magnetic spectrum detected in a non-magnetic state;

and S2030 step: adjusting a light emitting angle and a receiving angle to enable the spectrum of the scattered light to be optimal, wherein the light emitting angle at the moment is taken as the optimal light emitting angle, and the receiving angle at the moment is taken as the optimal receiving angle;

s2040: and detecting the spectrum of the scattered light comprises a scattered light sampling period, wherein the scattered light sampling period comprises a nuclear magnetic resonance period which is less than 2 times, including a magnetization state period, a resonance state period and a relaxation state period, and the scattered light sampling period also comprises a nuclear magnetic resonance period which is more than 2 times, including the magnetization state period, the resonance state period and the relaxation state period.

3. The method according to claim 2, characterized in that the step S1000, including the step of operating the gradient magnetic field of S1100, specifically includes:

and S1110: the gradient magnetic field is arranged in the X-axis direction to be an X-gradient magnetic field, the main magnetic field and the X-gradient magnetic field are synthesized to form a synthesized magnetic field, and the magnetic field intensity of the synthesized magnetic field is in linear gradient distribution along the X-axis direction;

s1120: setting X-axis granularity according to the linear gradient distribution, dividing the detected object into X-axis layers in an X-axis gradient magnetic field according to the X-axis granularity, taking the X-axis layer farthest from the origin of coordinates as a layer 1, and inwards sequentially numbering the layers;

and S1130: the gradient magnetic field is arranged in the Y-axis direction and is a Y-gradient magnetic field, the main magnetic field and the Y-gradient magnetic field are synthesized to form a synthesized magnetic field, and the magnetic field intensity of the synthesized magnetic field presents linear gradient distribution along the Y-axis direction;

and a step S1140: setting Y-axis granularity according to the linear gradient distribution, dividing the detected object into Y-axis layers in a Y-gradient magnetic field according to the Y-axis granularity, taking the Y-axis layer farthest from the origin of coordinates as the 1 st layer, and sequentially numbering the layers inwards;

s1150, step: the gradient magnetic field is arranged in the Z-axis direction to be a Z-gradient magnetic field, the main magnetic field and the Z-gradient magnetic field are synthesized to form a synthesized magnetic field, and the magnetic field intensity of the synthesized magnetic field presents linear gradient distribution along the Z-axis direction;

s1160 step: setting Z-axis granularity according to the linear gradient distribution, dividing the detected object into Z-axis layers in a Z-gradient magnetic field according to the Z-axis granularity, taking the Z-axis layer farthest from the origin of coordinates as a layer 1, and inwards sequentially numbering the layers;

4. The method according to claim 3, further comprising a 0-dimensional overall detection step of S4100, specifically comprising: s4110: the working steps of the 0-dimensional integral nuclear magnetic resonance comprise:

s4120, closing the gradient magnetic field, and calculating the frequency of the overall excitation magnetic field of the detected object according to the specific protons and the magnetic field intensity of the main magnetic field;

s4130: adjusting the frequency of the excitation magnetic field to be the frequency of the whole excitation magnetic field, and starting the excitation magnetic field to enable specific protons in the detected object to enter the whole nuclear magnetic resonance;

s4140 step: detecting the whole nuclear magnetic spectrum of the detected object, and/or detecting the whole nuclear magnetic spectrum of more than one pre-configured calibration objects known to contain specific protons or specific molecular contents;

s4150 step: setting a detection point on the surface of the detected object, and detecting the surface scattered light spectrum of the detected object and/or detecting the surface scattered light spectrum of the calibration object; and/or the presence of a gas in the gas,

s4160 step: setting a detection point on the surface of a detected object, and detecting the surface scattering light spectrum of the detected object at an optimal light emitting angle and an optimal receiving angle, and/or detecting the surface scattering light spectrum of a calibration object at the optimal light emitting angle and the optimal receiving angle;

5. The method according to claim 4, further comprising a 1-dimensional layer detection step of S4200, specifically comprising: s4210: the 1-dimensional layer nuclear magnetic resonance working steps specifically comprise:

a step S4220 of loading an X gradient magnetic field to the detection region, dividing the detection region into one or more detection layers according to a combined magnetic field formed by the main magnetic field and the X gradient magnetic field for a specific proton, calculating the frequency of a layer excitation magnetic field of all the detection layers and the thickness of the detection layer, and calculating the maximum number of detection layers of an optical path through which scattered light can pass based on the attenuation of the excitation light and the scattered light in the detection layer;

and S4230: sequentially adjusting the frequency of the excitation magnetic field to be the frequency of the layer excitation magnetic field of all the detection layers, and sequentially starting the excitation magnetic field to enable specific protons in the detection layers to enter layer nuclear magnetic resonance;

and S4240: layer nuclear magnetic spectrum of all the detection layers is detected by layer scanning;

and S4250: setting a detection point on the surface of the detected object, and detecting the surface scattering light spectrum of the detected object, and/or detecting the surface scattering light spectrum of the detected object at the optimal light-emitting angle and the optimal receiving angle; and/or, step S4260: for a detected object of a living body with skin, and the known skin thickness is less than the maximum detection thickness, calculating the number of detection layers where the skin and the subcutaneous tissue are located, and adjusting an X gradient magnetic field to detect the nuclear magnetic spectrum and the surface scattering light spectrum of the layers of the skin and the subcutaneous tissue;

and S4270: the layer scattered light spectrum including the layer magnetization spectrum, the layer resonance spectrum, and the layer relaxation spectrum is calculated by subtracting the scattered light spectra above and below the specified layer from the surface scattered light spectrum by an inclusion layer attenuation method based on the surface scattered light spectrum including the scattered light spectrum of all the layers up to the number of detection layers and the layer nuclear magnetic resonance and surface scattered light spectrum of the specified layer in the number of detection layers up to the number of detection layers.

6. The method according to claim 5, further comprising a 2-dimensional bar detection step of S4300, specifically comprising: s4310: the 2-dimensional strip nuclear magnetic resonance working steps specifically comprise:

s4320, loading an X gradient magnetic field and a Y gradient magnetic field on the detection layer, dividing the detection layer into more than one detection strip according to a synthetic magnetic field formed by the main magnetic field, the X gradient magnetic field and the Y gradient magnetic field, calculating the frequency of a strip excitation magnetic field, and calculating the frequency of the strip excitation magnetic field of all the detection strips and the thickness of the detection strips aiming at specific protons;

s4330: sequentially adjusting the frequency of the excitation magnetic field to be the frequency of the strip excitation magnetic field of all the detection strips, and sequentially starting the excitation magnetic field to enable specific protons in the detection strips to enter strip nuclear magnetic resonance;

s4340 step: strip nuclear magnetic spectrum of all the detection strips is detected by strip scanning;

s4350: setting a detection point on the surface of the detection object of the detection strip along the X axis, detecting a surface scattered light spectrum, and calculating a strip scattered light spectrum according to the layer scattered light spectrum; and/or, detecting the strip scattered light spectrum of the detected object at the optimal light emitting angle and the optimal receiving angle.

7. The method according to claim 6, further comprising a 3-dimensional bit detection step of S4400, specifically comprising: s4410: the 3-dimensional nuclear magnetic resonance working steps specifically comprise:

s4420, loading an X gradient magnetic field, a Y gradient magnetic field and a Z gradient magnetic field for the detection strip, dividing the detection strip into more than one detection position according to a combined magnetic field formed by the main magnetic field, the X gradient magnetic field, the Y gradient magnetic field and the Z gradient magnetic field aiming at specific protons, and calculating the frequency of bit excitation magnetic fields of all the detection positions and the width of the detection positions;

step S4430: sequentially adjusting the frequency of the excitation magnetic field to be the frequency of bit excitation magnetic fields of all the detection bits, and sequentially starting the excitation magnetic field to enable specific protons in the detection bits to enter bit nuclear magnetic resonance;

s4440: bit scanning and detecting bit nuclear magnetic spectra of all the detection bits;

s4450: setting a detection point on the surface of the detection object at the detection position along the X axis, detecting a surface scattered light spectrum, and calculating a position scattered light spectrum according to the layer scattered light spectrum; and/or detecting the bit scattered light spectrum of the detected object at the optimal light emitting angle and the optimal receiving angle.

8. The method according to claim 4, further comprising a step of 0-dimensional quantum magneto-optical multidimensional resolution of S3100, comprising: step S3110: executing the steps S4110 to S4160 to obtain the whole nuclear magnetic spectrum and the surface scattered light spectrum of the detection object and the calibration object;

s3120: establishing a comparison database according to the content of specific protons or specific molecules contained in the calibration object and the obtained integral nuclear magnetic spectrum and surface scattering optical spectrum, wherein the comparison database at least comprises specific proton names, specific molecule names, the content of specific protons and/or specific molecules, the integral nuclear magnetic spectrum, the surface scattering optical spectrum, the surface magnetization spectrum, the surface resonance spectrum, the surface relaxation spectrum and the surface non-magnetic optical spectrum, and/or optimizes the luminescence angle and the receiving angle;

s3130: and comparing and searching in a comparison database according to the surface magnetization spectrum, the surface resonance spectrum, the surface relaxation spectrum and the surface non-magnetic spectrum in the integral nuclear magnetic spectrum and the surface scattering light spectrum of the detected object, finding out the content of the closest calibration object, and calculating the detection content of the specific proton or the specific molecule in the detected object by adopting an interpolation method, a regression analysis method or a neural network method.

9. The method according to claim 5, further comprising a step of 1-dimensional quantum magneto-optical multidimensional resolution of S3200, specifically comprising: step S3210: executing the steps S4210 to S4270, and acquiring layer nuclear magnetic spectra and layer scattered light spectra of all layers in the maximum detection layer number;

step S3220: and according to the layer magnetization spectrum, the layer resonance spectrum, the layer relaxation spectrum and the layer non-magnetic spectrum in the layer nuclear magnetic spectrum and the layer scattering light spectrum of the detected object, which are obtained by detection, comparing and searching in a comparison database, finding out the content of the closest calibration object, and calculating the detection content of specific protons or specific molecules of the specified layer in the detected object by adopting an interpolation method, a regression analysis method or a neural network method.

10. The method according to claim 6, further comprising a step of 2-dimensional quantum magneto-optical multidimensional resolution of S3300, specifically comprising:

s3310 step: performing the steps S4310 to S4350 to obtain a bar nmr spectrum and a bar scattered light spectrum of all the detection layers of the maximum number of detection layers;

and S3320: according to the strip nuclear magnetic spectrum and the strip scattered light spectrum of all the detection strips, comparing and searching in a comparison database, finding out the content of the closest calibration object, and calculating the detection content of the specific proton or the specific molecule of the specified strip in the detection object by adopting an interpolation method, a regression analysis method or a neural network method; or the like, or, alternatively,

and S3330: and calculating the detection content of the specific proton or the specific molecule of the specified strip in the detection object by adopting a weighted average method, a regression analysis method and a convolution neural network algorithm according to the strip nuclear magnetic spectrum and the strip scattered light spectrum of all the detection strips.

11. The method of claim 7, further comprising a step of 3-dimensional quantum magneto-optical multidimensional resolution of S3400, specifically comprising:

s3410 step: performing the steps S4410 to S4450 to obtain bit nuclear magnetic spectra and bit scattered light spectra of all the detection bits on all the detection strips in all the detection layers of the maximum number of detection layers;

step S3420: according to the bit nuclear magnetic spectrum and the bit scattered light spectrum of all the detection bits, comparing and searching in a comparison database, finding out the content of the closest calibration object, and calculating the detection content of the specific proton or the specific molecule of the designated bit in the detection object by adopting an interpolation method, a regression analysis method or a neural network method; or the like, or, alternatively,

step S3430: and calculating the detection content of specific protons or specific molecules of designated positions in the detected object by adopting a weighted average method, a regression analysis method and a convolutional neural network algorithm according to the bit nuclear magnetic spectrum and the bit scattered light spectrum of all the detection positions.

12. The method according to any one of claims 8 to 11, further comprising a step S3500, in particular comprising: s3510: and searching abnormal analysis data according to time change data of nuclear magnetic spectra and scattered light spectra of the calibration object and the detection object during conversion of the nuclear magnetic resonance state, and calculating the detection content of specific protons or specific molecules of designated positions in the detection object by adopting a weighted average method, a regression analysis method and a convolutional neural network algorithm.

13. The method of claim 9, further comprising:

s3550 step: and arranging according to the detection content of all the detection layers and a right-angle three-dimensional coordinate system of an X axis, a Y axis and a Z axis, and calculating and displaying an image.

14. The method of claim 10, further comprising:

s3550 step: and arranging according to the detection content of all the detection strips and a right-angle three-dimensional coordinate system of an X axis, a Y axis and a Z axis, and calculating and displaying an image.

15. The method of claim 11, further comprising:

s3550 step: and arranging according to the detection content of all the detection positions and a right-angle three-dimensional coordinate system of an X axis, a Y axis and a Z axis, and calculating and displaying an image.