CN115445682A - Liquid transfer workstation and use method thereof - Google Patents
Liquid transfer workstation and use method thereof Download PDFInfo
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- CN115445682A CN115445682A CN202211275757.2A CN202211275757A CN115445682A CN 115445682 A CN115445682 A CN 115445682A CN 202211275757 A CN202211275757 A CN 202211275757A CN 115445682 A CN115445682 A CN 115445682A
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- 239000007788 liquid Substances 0.000 title claims description 45
- 238000012546 transfer Methods 0.000 title claims description 23
- 238000000034 method Methods 0.000 title claims description 10
- 239000011148 porous material Substances 0.000 claims abstract description 15
- 230000005540 biological transmission Effects 0.000 claims abstract description 10
- 230000000149 penetrating effect Effects 0.000 claims description 9
- 238000001125 extrusion Methods 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 3
- 230000006978 adaptation Effects 0.000 claims 2
- 230000009347 mechanical transmission Effects 0.000 abstract description 2
- 230000007246 mechanism Effects 0.000 abstract description 2
- 230000001360 synchronised effect Effects 0.000 abstract description 2
- 230000008569 process Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 230000000087 stabilizing effect Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000007877 drug screening Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000012177 large-scale sequencing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
- B01L3/0213—Accessories for glass pipettes; Gun-type pipettes, e.g. safety devices, pumps
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/54—Supports specially adapted for pipettes and burettes
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Abstract
The invention relates to the technical field of pipetting workstations and discloses a small pipetting workstation which comprises a placing box, wherein the top surface of the placing box is fixedly connected with an operating platform, and an operating platform component part, a pipetting mechanical arm transmission part, a pipetting gun quick-change structure part and an electric cabinet are arranged above the placing box; the operating platform assembly part comprises a first rotating rod. A machine frame protection part is formed by the rear shell, the base, the top plate and the shell, and a mechanical transmission part is formed by the lead screw, the lead screw sliding block and the synchronous pulley mechanism; the cam operating table component part is used for quickly and manually controlling the pore plate in the Y-axis direction, so that the repeated positioning precision is high; through pipetting gun quick change structure part, the locking lever card is inside the snap ring to link together pipetting gun and connecting box, through dovetail and locking lever, realize the quick change pipetting gun, improve the convenience that the pipetting gun was changed, reduce the repetition location to the pipetting gun, improve the accuracy that the pipetting gun pipetted.
Description
Technical Field
The invention relates to the technical field of liquid transfer workstations, in particular to a liquid transfer workstation and a use method thereof.
Background
The pipetting workstation is a device for carrying and treating liquid, has the characteristics of high automation, high precision, high compatibility, high cost performance, high throughput and the like, can realize the functions of continuous gradient dilution, liquid distribution, addition, combination, continuous gradient dilution and the like among microporous plates, and is widely applied to large-scale pipetting treatment such as genomic researches on nucleic acid extraction, construction of various biological laboratory systems, large-scale sequencing and the like, drug screening, protein analysis and the like. Need use the orifice plate when moving liquid workstation and move liquid, 3 large-scale automatic liquid-moving equipment that present market has need input accurate figure when moving the orifice plate and adjust the orifice plate position, have increased the difficulty of adjusting the orifice plate, need spend the plenty of time to ensure the precision of removal, lead to the regulation time overlength, influence operating efficiency. Accordingly, a pipetting station and a method for using a pipetting station are proposed.
Disclosure of Invention
The object of the present invention is to provide a small pipetting station that solves the problems mentioned in the background above.
In order to achieve the purpose, the invention provides the following technical scheme: a small-sized liquid transfer workstation comprises a placing box, wherein an operation table is fixedly connected to the top surface of the placing box, and an operation table component part, a liquid transfer mechanical arm transmission part, a liquid transfer gun quick-change structure part and an electric cabinet are arranged above the placing box;
the operation panel assembly part comprises a first rotating rod, the first rotating rod is located above the operation panel, the bottom end face of the first rotating rod penetrates through the top face of the operation panel and extends to the lower portion of the operation panel, the first surface of the first rotating rod is rotatably connected with the inner wall of the operation panel, a rotating button is fixedly connected to the top end of the first rotating rod, a cam is fixedly arranged on the first surface of the rotating rod, a ratchet wheel is fixedly connected to the bottom face of the cam, a U-shaped block is arranged in front of the ratchet wheel, the top face of the U-shaped block is fixedly connected with the bottom face of the operation panel, a rotating rod second is fixedly connected to the inner side bottom face of the U-shaped block, a ratchet plate is arranged above the rotating rod second bottom face, the top end face of the rotating rod second top end face penetrates through the bottom face of the ratchet plate and extends to the upper portion of the ratchet plate, the inner wall of the ratchet plate is rotatably connected with the surface of the rotating rod second rotating rod, the top end face of the rotating rod is fixedly connected with the bottom face of the operation panel, the ratchet wheel side is meshed with the surface of the ratchet plate, an adjusting plate is arranged in front of the cam, and the adjusting plate is connected with the placing frame.
Preferably, the operating table bottom surface is fixedly connected with two first connecting plates, a bottom plate is arranged below the two first connecting plates, the bottom surfaces of the two first connecting plates are fixedly connected with the top surface of the bottom plate, a limiting rod is fixedly connected with the top surface of the bottom plate, a first through groove is vertically formed in the bottom surface of the operating table in a through mode, two first sliders are arranged inside the first through groove, the bottom surfaces of the two first sliders are fixedly connected with the bottom surface of an adjusting plate, a hollow groove is formed in the bottom surfaces of the two first sliders in a through mode, the inner wall of the two first sliders is connected with the limiting rod in a surface sliding mode, the two first sliders are matched with the limiting rod, a connecting rod is fixedly connected with the bottom surface of the operating table and is located on the right side of a ratchet plate, a first spring is fixedly connected with the left side surface of the connecting rod, a rear shell is arranged above the placing box, and a mounting base is fixedly connected with the bottom surface of the rear shell.
Preferably, the liquid-transferring mechanical arm transmission part comprises a rodless guide rail, the bottom surface of the rodless guide rail is rotatably connected with the top surface of the mounting base through a bearing seat, the rear side surface of the rear shell is provided with two through grooves, the inside of each through groove is provided with a limiting block, the rear side of the rodless guide rail is provided with a clamp, the right side of the clamp is fixedly connected with a connecting block, the two rear sides of the limiting blocks are uniformly connected with the front side of the connecting block, the inner side surfaces of the limiting blocks are fixedly connected with the outer side surface of a moving block, the surfaces of the limiting blocks are respectively connected with the inner walls of the two through grooves in a sliding manner, the right side of the clamp is connected with a T-shaped plate, a moving block is arranged above the rodless guide rail, the top end surface of the rodless guide rail slidably penetrates through the top surface of the moving block and extends to the upper side of the moving block, the front moving block and the front of the T-shaped block are fixedly connected with two sliding blocks, the top surface of the mounting base is fixedly connected with two supporting frames, the rear side surfaces of the two supporting frames are fixedly connected with limiting plates, the two surfaces of the two limiting plates in a wedge shape, and the two sliding manner are matched with the limiting plates.
Preferably, two the support frame top is provided with the mounting panel, two the support frame side all with mounting panel side fixed connection, the mounting panel openly and three openly all with backshell medial surface fixed connection of connecting plate, three bottom surface fixedly connected with motors of connecting plate one, no pole guide rail top surface runs through three bottom surfaces of connecting plate and extends to three tops of connecting plate, no pole guide rail surface rotates with three inner walls of connecting plate to be connected, backshell top surface fixedly connected with roof.
Preferably, a connecting box is arranged in front of the clamp, and the inner wall of the clamp is in threaded connection with the inner wall of the connecting box through a bolt.
Preferably, the quick-change structure part of the liquid transfer gun comprises the liquid transfer gun, a dovetail groove is formed in the rear side face of the liquid transfer gun in a penetrating mode, a dovetail block is fixedly connected to the front face of the connecting box, the inner wall of the dovetail groove is in sliding connection with the surface of the dovetail block, the dovetail groove is matched with the dovetail block, a fixed block is fixedly connected to the front face of the connecting box, a snap ring is arranged in front of the fixed block, the rear end face of the snap ring fixedly penetrates through the front face of the fixed block and extends into the fixed block, a first empty groove is formed in the rear side face of the liquid transfer gun in a penetrating mode, a lock rod is arranged on the front face of the liquid transfer gun, a third empty groove and a fourth empty groove are formed in the top face of the lock rod, a slide rod is arranged in the third empty groove, a button fixedly connected with the top face of the slide rod is arranged in the bottom face of the slide rod, the third empty groove extends into the fourth empty groove, and a second spring is sleeved on the surface of the slide rod, the improved liquid transferring gun is characterized in that a button is fixedly connected to the bottom end face of the second spring, the bottom end face of the second spring is fixedly connected with the three inner walls of the empty groove, two convex blocks are arranged inside the four empty grooves and located below the sliding rod, the rear end face of the locking rod fixedly penetrates through the liquid transferring gun and extends to the inside of the empty groove, the surface of the locking rod is fixedly connected with the convex blocks, the rear end face of the locking rod penetrates through the clamping ring and extends to the inner wall of the clamping ring, the surface of the locking rod is connected with the inner wall of the clamping ring in an extrusion mode, the locking rod is matched with the clamping ring in a matched mode, the connecting box is provided with the empty groove II in a front penetrating mode, the rear side face of the liquid transferring gun is fixedly connected with the connecting plate II, the surface of the connecting plate is connected with the inner wall of the empty groove in a sliding mode, a liquid transferring gun is arranged inside, and the bottom end face of the liquid transferring gun penetrates through the inside of the liquid transferring gun and extends to the below the liquid transferring gun.
Preferably, place roof face fixedly connected with electric cabinet, the inside side fixedly connected with fixed plate of electric cabinet, the fixed plate left side is provided with the guide arm, the guide arm left end face passes through the bearing frame and is connected with the inside left surface rotation of electric cabinet, the electric cabinet trailing flank link up and has seted up the through-hole, the mount pad leading flank runs through the through-hole and extends to inside the electric cabinet, the guide arm right-hand member face slides and runs through mount pad left surface and fixed plate left surface and extend to the fixed plate right side, place the inside right flank fixedly connected with motor two, it is provided with the display screen to place roof face.
In order to achieve the purpose, the invention provides the following technical scheme: a method of using a pipetting station comprising the steps of:
placing the pore plate in a placing frame, rotating a rotating button, and adjusting the position of the placing frame through rotation of a cam to realize Y-axis adjustment of the pore plate;
moving the liquid transfer gun to the left side of the connecting box, and sliding the dovetail block to the inner wall of the dovetail groove from front to back so that the dovetail block and the dovetail groove are mutually attached;
the lock rod is placed in the clamp, the button is pressed, the slide rod extrudes the bump to enable the bump to pop out, and the button is loosened to enable the lock rod to be clamped in the clamp ring to rapidly connect the connecting box and the liquid-transferring gun together;
starting a motor I, driving the clamp and the liquid-transfering gun to move in a Z axis mode through the rodless guide rail, and sucking detection liquid through the liquid-transfering gun;
starting a motor II, and enabling a guide rod to rotate to drive the mounting seat and the moving gun to move along the X axis;
the liquid absorbed in the liquid-transfering gun is transferred to different pore plates by moving the liquid-transfering gun along X-axis and Z-axis.
Compared with the prior art, the invention has the beneficial effects that: the liquid transfer workstation forms a rack protection part through a rear shell, a base, a top plate and a shell, and forms a mechanical transmission part through a screw rod, a screw rod sliding block and a synchronous pulley mechanism; the cam operating table component part is used for quickly and manually controlling the pore plate in the Y-axis direction, so that the repeated positioning precision is high; through the quick-change structure part of the liquid-transferring gun, the lock rod is clamped inside the clamping ring, so that the liquid-transferring gun is connected with the connecting box, the quick-change liquid-transferring gun is realized through the dovetail groove and the lock rod, the convenience of replacing the liquid-transferring gun is improved, the repeated positioning of the liquid-transferring gun is reduced, and the liquid-transferring accuracy of the liquid-transferring gun is improved; through the transmission part of the pipetting mechanical arm, the lead screw rotates to drive the moving block and the clamp to move up and down along the Z axis, so that the carrier can move more stably on the Z axis module upright column, the human errors caused by manual operation are reduced, and the pipetting accuracy of sample treatment is improved; the limiting block and the sliding block are matched with each other, so that the carrier is limited and stabilized, the carrier is more stable in the up-and-down moving process, and the stability of the design mechanics of the Z-axis module column of the liquid transfer workstation is improved; the Z-axis module upright post is formed into a containing space through the rear shell, the base, the top plate and the shell, an opening moving up and down is hidden, the Z-axis module upright post is prevented from being polluted, and meanwhile, the Z-axis module upright post is simpler in appearance and convenient to operate; through motor one, the lead screw drives the mount pad and realizes that the X axle removes, removes to the mount pad through electric cabinet and through-hole and plays the stabilizing effect, reduces the skew in the mount pad removes, improves the mount pad and drives the carrier and remove the stability of rifle at the X axle removal.
Drawings
FIG. 1 is a front perspective view of the present invention;
FIG. 2 is a top perspective view of the present invention;
FIG. 3 is a top cross-sectional perspective view of an electrical cabinet of the present invention;
FIG. 4 is a front perspective view of the operator station of the present invention;
FIG. 5 is a bottom perspective view of the cam of the present invention;
FIG. 6 is an enlarged perspective view of area A of FIG. 5 in accordance with the present invention;
FIG. 7 is a left side cutaway perspective view of the operator station of the present invention;
FIG. 8 is a front perspective view of a rodless guide rail of the present invention;
FIG. 9 is a top cross-sectional perspective view of the rear housing of the present invention;
FIG. 10 is a rear left perspective view of the present invention;
FIG. 11 is a front perspective view of the connection box of the present invention;
FIG. 12 is a left side perspective view of a pipette of the present invention;
FIG. 13 is a front perspective view of the locking bar of the present invention;
FIG. 14 is a top perspective view of the connecting rod of the present invention.
In the figure: the device comprises a placing box 1, a display screen 2, an operating platform 3, an operating platform assembly part 4, a first rotating rod 401, a rotating button 402, a cam 403, a ratchet 404, a ratchet plate 405, a connecting rod 406, a first spring 407, a U-shaped block 408, a limiting rod 409, a bottom plate 410, an adjusting plate 411, a first through groove 412, a first slider 413, a second rotating rod 414, a first connecting plate 415, a placing frame 416, a pipetting mechanical arm transmission part 5, a rodless guide rail 501, a moving block 502, a limiting plate 503, a clamp 504, a connecting block 505, a second through groove 506, a supporting frame 507, a limiting block 508, a mounting plate 509, a second slider 510, a T-shaped plate 511, a pipetting gun quick-change structure part 6, a pipetting gun 601, a dovetail groove 603, a second connecting plate 604, a first empty groove 606, a locking rod 607, a dovetail block 608, a fixing block 609, a clamping ring 610, 611, a bump 612, a sliding rod 613, a button 614, a second spring 615, a mounting seat 7, a connecting box 8, a second empty groove 9, a rear shell 10, a first motor 11, a third motor 12, a top plate 13, an electric cabinet 14, a second motor 15, a fixing plate 16 and a guide rod 17.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-14, the present invention provides a technical solution: a liquid transfer workstation comprises a placing box 1, wherein the top surface of the placing box 1 is fixedly connected with an operating platform 3, and an operating platform assembly part 4, a liquid transfer mechanical arm transmission part 5, a liquid transfer gun quick-change structure part 6 and an electric cabinet 14 are arranged above the placing box 1;
the console module 4 comprises a console module 4 comprising a first rotating rod 401, the first rotating rod 401 is located above the console 3, the bottom end surface of the first rotating rod 401 extends to the lower side of the console 3 through the top surface of the console 3, the surface of the first rotating rod 401 is connected with the inner wall of the console 3 in a rotating manner, the top end of the first rotating rod 401 is fixedly connected with a rotating button 402, the first rotating rod 401 is fixedly sleeved with a cam 403, the bottom surface of the cam 403 is fixedly connected with a ratchet 404, a U-shaped block 408 is arranged in front of the ratchet 404, the top surface of the U-shaped block 408 is fixedly connected with the bottom surface of the console 3, a second rotating rod 414 is fixedly connected with the inner side bottom surface of the U-shaped block 408, a ratchet plate 405 is arranged above the second rotating rod 414, the top end surface of the ratchet plate 405 extends to the upper side of the ratchet plate 405, the inner wall of the ratchet plate 405 is connected with the surface of the second rotating rod 414 in a rotating manner, and the top end surface of the rotating rod 414 is fixedly connected with the bottom surface of the console 3, the side surface of the ratchet 404 is engaged with the surface of a ratchet plate 405, an adjusting plate 411 is arranged in front of a cam 403, the front surface of the adjusting plate 411 is connected with the surface of the cam 403 in a squeezing way, the top surface of the adjusting plate 411 is fixedly connected with a placing frame 416, the bottom surface of an operating platform 3 is fixedly connected with two connecting plates I415, a bottom plate 410 is arranged below the two connecting plates I415, the bottom surfaces of the two connecting plates I415 are both fixedly connected with the top surface of the bottom plate 410, the top surface of the bottom plate 410 is fixedly connected with a limiting rod 409, a through groove I412 is vertically penetrated through the bottom surface of the operating platform 3, two sliders I413 are arranged in the through groove I412, the bottom surfaces of the two sliders I413 are fixedly connected with the bottom surface of the adjusting plate 411, empty grooves are penetrated through respectively, the inner walls of the two sliders I413 are slidably connected with the surface of the limiting rod 409, the two sliders I413 are matched with the limiting rod 409, the bottom surface of the operating platform 3 is fixedly connected with a connecting rod 406, the connecting rod 406 is positioned at the right side of the ratchet plate 405, the left side face of the connecting rod 406 is fixedly connected with a first spring 407, the left end face of the first spring 407 is fixedly connected with the right side face of the ratchet plate 405, a rear shell 10 is arranged above the placing box 1, the bottom face of the rear shell 10 is fixedly connected with a mounting seat 7, the adjusting plate drives a connected sliding block to move on the surface of the limiting rod through moving the adjusting plate, and a stabilizing effect is guaranteed when the adjusting plate is adjusted, so that the offset driven by adjusting the pore plate is reduced, the sample processing result is stable and reliable, the cross contamination is less, the processing speed is high, the flexibility is good, the operation is convenient, the liquid transferring device can be suitable for an 8-channel liquid transferring device to quickly transfer liquid to the pore plate, and the manual control of the Y-axis direction of the pore plate is realized through the operating platform component part 4; the pipetting mechanical arm transmission part 5 comprises a rodless guide rail 501, the bottom surface of the rodless guide rail 501 is rotatably connected with the top surface of a mounting seat 7 through a bearing seat, the rear side surface of a rear shell 10 is provided with two through grooves 506 in a penetrating way, the inside of the two through grooves 506 is provided with a limiting block 508, the rear side of the rodless guide rail 501 is provided with a clamp 504, the right side of the clamp 504 is fixedly connected with a connecting block 505, the front side surfaces of the uniform connecting blocks 505 at the rear side surfaces of the two limiting blocks 508 are fixedly connected with the outer side surface of a moving block 502, the surfaces of the two limiting blocks 508 are respectively connected with the inner walls of the two through grooves 506 in a sliding way, the right side of the clamp 504 is connected with a T-shaped plate 511, the moving block 502 is arranged above the rodless guide rail 501, the top end surface of the rodless guide rail 501 penetrates through the top surface of the moving block 502 and extends to the upper part of the moving block 502, the front surface of the moving block 502 and the front surface of the T-shaped plate 511 are both fixedly connected with a second sliding block 510, the top surface of the mounting seat 7 is fixedly connected with two supporting frames 507, the rear side surfaces of the two supporting frames 507 are fixedly connected with limiting plates 503, the surfaces of the two limiting plates 503 are wedge-shaped, the inner wall of a second slider 510 is in sliding connection with the surfaces of the limiting plates 503, the second slider 510 is matched with the limiting plates 503, a mounting plate 509 is arranged above the two supporting frames 507, the side surfaces of the two supporting frames 507 are fixedly connected with the side surfaces of the mounting plate 509, the front surface of the mounting plate 509 and the front surface of a third connecting plate 12 are fixedly connected with the inner side surface of the rear shell 10, the bottom surface of the third connecting plate 12 is fixedly connected with a first motor 6, the top surface of the rodless guide rail 501 penetrates through the bottom surface of the third connecting plate 12 and extends to the top surface of the third connecting plate 12, the surface of the rodless guide rail 501 is rotatably connected with the inner wall of the third connecting plate 12, the top surface of the rear shell 10 is fixedly connected with a top plate 13, and the rodless guide rail rotates to drive the moving block and the clamp to move up and down along the Z axis through the liquid-moving mechanical arm transmission part 5, the clamp can move more stably on the Z-axis module vertical column, so that human errors caused by manual operation are reduced, and the pipetting accuracy of sample treatment is improved; the limiting block and the sliding block are matched with each other, so that the clamp is limited and stabilized, the clamp is more stable in the up-and-down moving process, and the stability of the design mechanics of the Z-axis module stand of the liquid transfer workstation is improved; the Z-axis module vertical column forms a containing space through the rear shell, the base, the top plate and the shell, an opening moving up and down is hidden, the Z-axis module vertical column is prevented from being polluted, and meanwhile, the Z-axis module vertical column is simpler in appearance and convenient to operate; the front part of the clamp 504 is provided with a connecting box 8, the inner wall of the clamp 504 is in threaded connection with the inner wall of the connecting box 8 through a bolt, the quick-change structure part 6 of the pipette comprises a pipette 601, the rear side surface of the pipette 601 is provided with a dovetail groove 603 in a penetrating way, the front surface of the connecting box 8 is fixedly connected with a dovetail block 608, the inner wall of the dovetail groove 603 is in sliding connection with the surface of the dovetail block 608, the dovetail groove 603 is matched with the dovetail block 608, the front surface of the connecting box 8 is fixedly connected with a fixed block 609, the front part of the fixed block 609 is provided with a snap ring 610, the rear end surface of the snap ring 610 fixedly penetrates through the front surface of the fixed block 609 and extends into the fixed block 609, the rear side surface of the pipette 601 is provided with a first empty groove 606, the front surface of the pipette 601 is provided with a lock lever 607, the top surface of the lock lever 607 is provided with a third empty groove and a fourth empty groove, the third inner part of the empty groove is provided with a slide rod 613, a button 614 fixedly connected with the top surface of the slide rod 613, the bottom end surface of the slide rod extends into the empty groove through the third groove, the surface of the sliding rod 613 is sleeved with a second spring 615, the bottom end surface of the second spring 615 is fixedly connected with a button 614, the bottom end surface of the second spring 615 is fixedly connected with the inner wall of the third hollow groove, two convex blocks 612 are arranged inside the fourth hollow groove, the two convex blocks 612 are positioned below the sliding rod 613, the rear end surface of the lock rod 607 fixedly penetrates through the front surface of the pipette 601 and extends into the first hollow groove 606, the surface of the lock rod 607 is fixedly connected with convex blocks, the rear end surface of the lock rod 607 penetrates through the front surface of the snap ring 610 and extends into the inner wall of the snap ring 610, the surface of the lock rod 607 is connected with the inner wall of the snap ring 610 in a pressing manner, the lock rod 607 is matched with the snap ring 610, the front surface of the connecting box 8 is provided with a second hollow groove 9 in a penetrating manner, the rear side surface of the pipette 601 is fixedly connected with a second connecting plate 604, the surface of the connecting plate is connected with the inner wall of the second hollow groove 9 in a sliding manner, a pipette 611 is arranged inside the pipette 601, the bottom end surface of the pipette 601 extends below the pipette 601, through the quick-change structure part 6 of the liquid-transfering gun, the lock rod is clamped in the clamping ring, so that the liquid-transfering gun is connected with the connecting box, and through the dovetail groove and the lock rod, the quick-change liquid-transfering gun is realized, the convenience of replacing the liquid-transfering gun is improved, the repeated positioning of the liquid-transfering gun is reduced, and the liquid-transfering accuracy of the liquid-transfering gun is improved; the top surface of the placing box 1 is fixedly connected with an electric cabinet 14, the side surface inside the electric cabinet 14 is fixedly connected with a fixed plate 16, the left side of the fixed plate 16 is provided with a guide rod 17, the left end surface of the guide rod 17 is rotatably connected with the left side surface inside the electric cabinet 14 through a bearing seat, the rear side surface of the electric cabinet 14 is provided with a through hole in a through manner, the front side surface of the mounting seat 7 extends into the electric cabinet 14 through the through hole, the right end surface of the guide rod 17 slidably extends to the right side surface of the fixed plate 16 through the left side surface of the mounting seat 7 and the left side surface of the fixed plate 16, the right side surface inside the placing box 1 is fixedly connected with a motor II 15, and the guide rod drives the mounting seat to realize X-axis movement through the electric cabinet and the through hole, so that the mounting seat can be moved stably, the offset in the movement of the mounting seat is reduced, and the stability of the clamp and the moving gun driven by the mounting seat in the X-axis movement is improved; the top surface of the placing box 1 is provided with a display screen 2.
The invention provides a technical scheme that: a method of using a pipetting station comprising the steps of:
placing the pore plate in a placing frame 416, rotating a rotating knob 402, and rotating and adjusting the position of the placing frame 416 through a cam 403 to realize Y-axis adjustment of the pore plate;
moving the liquid-transferring gun 601 to the left side of the connecting box 8, and sliding the dovetail block 608 to the inner wall of the dovetail groove 603 from front to back so that the dovetail block 608 and the dovetail groove 603 are attached to each other;
the lock lever 607 is placed inside the clip 650, the button 614 is pressed, the sliding rod 613 presses the bump 612, the bump 612 is ejected, the button 614 is released, the lock lever 607 is clipped inside the snap ring 610, and the connecting box 8 and the pipette 601 are quickly connected together;
starting a first motor 11, driving the clamp 504 and the liquid-transferring gun 601 to move in a Z axis mode through the rodless guide rail 501, and sucking detection liquid through the liquid-transferring gun 601;
starting a second motor 15, and enabling a guide rod 17 to rotate to drive the mounting base 7 and the movable gun 601 to move along the X axis;
the liquid absorbed in the liquid-transfering gun 601 is transferred to different pore plates by moving the liquid-transfering gun 601 along the X axis and the Z axis.
When the liquid carrier is used, when the 96-hole plate and the 384-hole plate of the liquid carrier are switched according to requirements, the relative positions of the centers of the 96-hole plate and the 384-hole plate are different by 2.25mm in Y-axis and X-axis directions due to the fact that the overall dimensions of the 96-hole plate and the 384-hole plate are consistent, the number, the size and the distance among the holes are changed, the X-axis direction is controlled through a program end of a shaft module, and the Y-axis direction is manually controlled through the operating platform assembly part 4; need realize respectively adjusting once backward forward when 96 orifice plates switch 384 orifice plates, just enable all hole liquid distribution of 384 orifice plates and accomplish, place the orifice plates in placing frame 416, adjust a shelves forward through manual regulation turn-button 402, turn-button 402 drives a 401 rotation of the dwang of connecting, make a 401 rotation of dwang drive cam 403 of connecting rotate, cam 403 surface extrusion regulating plate 411, make regulating plate 411 move forward, regulating plate 411 drives the frame 416 of placing of connecting and carries out the position of adjusting forward, thereby realize adjusting the orifice plate position forward, adjust a shelves backward through manual regulation turn-button 402 in the same way, thereby realize adjusting the orifice plate position backward. The current cam 403 is provided with four clamping grooves which are divided into three steps, the shortest side is 15mm to the center of the rotating shaft, the middle side is 17.25mm, the longest side is 19.5mm, and each step can realize displacement of 2.25mm, so that quick centering action after the switching of the pore plates is changed is realized; the cam 403 rotates, the cam 403 drives the connecting ratchet 404 to rotate, and the ratchet plate 405 limits the ratchet, so that the adjusting plate 411 can keep a stable state after adjustment; when the adjusting plate 411 moves, the adjusting plate 411 drives the connected first sliding block 413 to move on the surface of the limiting rod 409, so that a stabilizing effect is guaranteed when the adjusting plate 411 is adjusted;
the liquid-transferring gun 601 is connected with the connecting box 8 by putting the lock rod 607 into the card 610, pressing the button 614, pressing the connected spring 615 by the button 614, enabling the button 614 to drive the sliding rod 613 in the lock rod 607 to slide downwards, enabling the sliding rod 613 to press the bump 612 to enable the bump 612 to pop out, releasing the button 614, enabling the bump 612 to be clamped on the inner wall of the clamping ring 610, enabling the lock rod 607 to be clamped in the clamping ring 610; when the locking lever 607 needs to be taken out from the inside of the snap ring 610, the locking lever 607 can be taken out from the inside of the snap ring 610 by pressing the button 614 and pulling out the locking lever 607; sliding the dovetail block 608 to the inner wall of the dovetail groove 603 from front to back, so that the dovetail block 608 and the dovetail groove 603 are attached to each other, and the liquid transfer gun 601 is connected with the connecting box 8 more firmly;
the movable block 502 is driven to move on the rodless guide rail 501 through the rotation of the rodless guide rail 501, so that the movable block 502 drives the connected second sliding block 510 to move on the limiting plate 503, meanwhile, the movable block 502 drives the connected two limiting blocks 508 to move in the two through grooves 506, further, the two limiting blocks 508 drive the connected connecting block 505 to move up and down, the connecting block 505 drives the connected clamp 504 to move up and down, the clamp 504 drives the liquid-moving gun 601 to move up and down, therefore, the clamp 504 and the liquid-moving gun 601 can move up and down along the Z axis, and the clamp 504 can move more stably on the Z axis module assembling column; the clamp 504 moves, the T-shaped block 511 connected with the clamp 504 is driven to move up and down, the T-shaped block 511 drives the second connected sliding block 510 to move on the limiting plate 503, and the limiting block 503 and the second connected sliding block 510 are matched with each other to limit and stabilize the clamp 504, so that the clamp 504 is more stable in the up-and-down moving process.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in the embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. A liquid transfer workstation, including placing case (1), its characterized in that: an operation table (3) is fixedly connected to the top surface of the placing box (1), and an operation table component part (4), a pipetting mechanical arm transmission part (5), a pipetting gun quick-change structure part (6) and an electric cabinet (14) are arranged above the placing box (1);
the operating platform assembly part (4) comprises a first rotating rod (401), the first rotating rod (401) is located above the operating platform (3), the bottom end face of the first rotating rod (401) penetrates through the top face of the operating platform (3) and extends to the position below the operating platform (3), the surface of the first rotating rod (401) is rotatably connected with the inner wall of the operating platform (3), a rotating button (402) is fixedly connected to the top end of the first rotating rod (401), a cam (403) is fixedly arranged on the surface of the first rotating rod (401), a ratchet wheel (404) is fixedly connected to the bottom face of the cam (403), a U-shaped block (408) is arranged in front of the ratchet wheel (404), the top face of the U-shaped block (408) is fixedly connected with the bottom face of the operating platform (3), a second rotating rod (414) is fixedly connected to the bottom face of the inner side of the U-shaped block (408), a ratchet plate (405) is arranged above the second rotating rod (414), the top end face of the second rotating rod (414) penetrates through the bottom face of the ratchet plate (405) and extends to the upper portion of the ratchet plate (405), the inner wall of the ratchet plate (405) is rotatably connected with the surface of the second ratchet plate (414), the ratchet wheel (403) is fixedly connected with the top face of the ratchet plate (411), and the adjusting plate (414), and the ratchet plate (411) is arranged on the side face of the operating platform (403), the adjusting plate (411) is connected with the cam (403) in a surface extrusion mode in the front face, and a placing frame (416) is fixedly connected to the top face of the adjusting plate (411).
2. A pipetting station as recited in claim 1 wherein: the bottom surface of the operating platform (3) is fixedly connected with two first connecting plates (415), a bottom plate (410) is arranged below the two first connecting plates (415), the bottom surfaces of the two first connecting plates (415) are fixedly connected with the top surface of the bottom plate (410), a limiting rod (409) is fixedly connected to the top surface of the bottom plate (410), a first through groove (412) is vertically formed in the bottom surface of the operating platform (3) in a penetrating mode, two first sliders (413) are arranged inside the first through groove (412), the bottom surfaces of the two first sliders (413) are fixedly connected with the bottom surface of an adjusting plate (411), empty grooves are formed in the bottom surfaces of the two first sliders (413) in a penetrating mode, the inner walls of the two first sliders (413) are connected with the limiting rod (409) in a surface sliding mode, the two first sliders (413) are matched with the limiting rod (409), the bottom surface of the operating platform (3) is fixedly connected with a connecting rod (406), the connecting rod (406) is located on the right side of a ratchet plate (405), the left side surface of the connecting rod (406) is fixedly connected with a first spring (407), the left side of the ratchet plate (405), a rear mounting base (10) is arranged above the placing box (1), and a rear mounting base (10) is arranged.
3. A pipetting station as recited in claim 2 wherein: the pipetting mechanical arm transmission part (5) comprises a rodless guide rail (501), the bottom surface of the rodless guide rail (501) is rotatably connected with the top surface of the mounting seat (7) through a bearing seat, the rear side surface of the rear shell (10) is provided with two through grooves (506) in a penetrating manner, the insides of the two through grooves (506) are respectively provided with a limiting block (508), the rear side of the rodless guide rail (501) is provided with a clamp (504), the right side of the clamp (504) is fixedly connected with a connecting block (505), the front side surfaces of the rear side surfaces of the two limiting blocks (508) are fixedly connected with the front side surface of the uniform connecting block (505), the inner side surfaces of the two limiting blocks (508) are fixedly connected with the outer side surface of the moving block (502), the surfaces of the two limiting blocks (508) are respectively slidably connected with the inner walls of the two through grooves (506), the right side of the clamp (504) is connected with a T-shaped plate (511), a moving block (502) is arranged above the rodless guide rail (501), the top surface of the rodless guide rail (501) slidably penetrates through the top surface of the moving block (502) and extends to the top surface of the moving block (502), the front surface of the mounting seat (7) is fixedly connected with two supporting frames (507), and the rear side surfaces of the two supporting frames (507), the surfaces of the two limiting plates (503) are wedge-shaped, the inner wall of the second sliding block (510) is in sliding connection with the surfaces of the limiting plates (503), and the second sliding block (510) is matched with the limiting plates (503).
4. A pipetting station as recited in claim 3 wherein: two support frame (507) top is provided with mounting panel (509), two support frame (507) side all with mounting panel (509) side fixed connection, mounting panel (509) openly and connecting plate three (12) openly all with backshell (10) medial surface fixed connection, three (12) bottom surfaces fixedly connected with motor (6) of connecting plate, no pole guide rail (501) top surface runs through three (12) bottom surfaces of connecting plate and extends to three (12) tops of connecting plate, no pole guide rail (501) surface is connected with three (12) inner wall rotations of connecting plate, backshell (10) top surface fixedly connected with roof (13).
5. A pipetting station as recited in claim 3 wherein: the connecting box (8) is arranged in front of the clamp (504), and the inner wall of the clamp (504) is in threaded connection with the inner wall of the connecting box (8) through a bolt.
6. A pipetting station as recited in claim 5 wherein: liquid-transfering gun quick change structure part (6) are including liquid-transfering gun (601), dovetail (603) have been seted up in liquid-transfering gun (601) trailing flank link up, connecting box (8) openly fixedly connected with dovetail block (608), dovetail (603) inner wall and dovetail block (608) surface sliding connection, dovetail (603) and dovetail block (608) looks adaptation, connecting box (8) openly fixedly connected with fixed block (609), fixed block (609) the place ahead is provided with snap ring (610), snap ring (610) rear end face is fixed to run through fixed block (609) openly and extends to fixed block (609) inside, liquid-transfering gun (601) trailing flank link up and sets up empty groove one (606), liquid-transfering gun (601) openly is provided with locking lever (607), empty groove three and empty groove four have been seted up to locking lever (607) top surface, empty groove three inside is provided with slide bar (613), slide bar (613) top surface fixed connection's button (614), slide bar (613) bottom surface runs through empty groove three and extends to empty groove four inside, slide bar (613) surface cover is equipped with two fixed spring (615), two fixed spring (615) inner wall (614) are connected with empty groove (614), two lug (612) are located slide bar (613) below, locking lever (607) rear end face is fixed to run through pipetting gun (601) and openly extends to empty groove one (606) inside, locking lever (607) fixed surface is connected with the lug, locking lever (607) rear end face runs through snap ring (610) and openly extends to snap ring (610) inner wall, locking lever (607) surface is connected with snap ring (610) inner wall extrusion, locking lever (607) and snap ring (610) looks adaptation, connecting box (8) openly link up and have seted up empty groove two (9), pipetting gun (601) trailing flank fixedly connected with connecting plate two (604), connecting plate two (604) surfaces and empty groove two (9) inner wall sliding connection, pipetting gun (601) inside is provided with pipette (611), pipette (611) bottom face runs through the inside bottom surface of pipetting gun (601) and extends to pipetting gun (601) below.
7. A pipetting station as recited in claim 4 wherein: place case (1) top surface fixedly connected with electric cabinet (14), electric cabinet (14) inside side fixedly connected with fixed plate (16), fixed plate (16) left side is provided with guide arm (17), guide arm (17) left end face passes through the bearing frame and is connected with the inside left surface rotation of electric cabinet (14), electric cabinet (14) trailing flank link up and has seted up the through-hole, mount pad (7) leading flank runs through the through-hole and extends to inside electric cabinet (14), guide arm (17) right-hand member face slides and runs through mount pad (7) left surface and fixed plate (16) left surface and extends to fixed plate (16) right side, place case (1) inside right side fixedly connected with motor two (15), it is provided with display screen (2) to place case (1) top surface.
8. A pipetting station and method of using the same according to claim 1, characterised by the steps of:
1) Placing the pore plate in a placing frame 416, rotating a rotating knob 402, and rotating and adjusting the position of the placing frame 416 through a cam 403 to realize Y-axis adjustment of the pore plate;
2) Moving the liquid transfer gun 601 to the left side of the connecting box 8, and sliding the dovetail block 608 to the inner wall of the dovetail groove 603 from front to back so that the dovetail block 608 and the dovetail groove 603 are attached to each other;
3) The lock lever 607 is placed inside the clip 650, the button 614 is pressed, the sliding rod 613 presses the bump 612, the bump 612 is ejected, the button 614 is released, the lock lever 607 is clipped inside the snap ring 610, and the connecting box 8 and the pipette 601 are quickly connected together;
4) Starting a first motor 11, driving the clamp 504 and the liquid-transferring gun 601 to move in a Z axis mode through the rodless guide rail 501, and sucking detection liquid through the liquid-transferring gun 601;
5) Starting a second motor 15, and enabling a guide rod 17 to rotate to drive the mounting base 7 and the moving gun 601 to move along the X axis;
6) The liquid absorbed in the liquid-transfering gun 601 is transferred to different pore plates by moving the liquid-transfering gun 601 along X-axis and Z-axis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211275757.2A CN115445682A (en) | 2022-10-18 | 2022-10-18 | Liquid transfer workstation and use method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211275757.2A CN115445682A (en) | 2022-10-18 | 2022-10-18 | Liquid transfer workstation and use method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110268627A1 (en) * | 2010-05-03 | 2011-11-03 | Integra Biosciences Corp. (Formerly Viaflo Corporation) | Manually Directed, Multi-Channel Electronic Pipetting System |
| US20130047751A1 (en) * | 2011-07-26 | 2013-02-28 | Eppendorf Ag | Positioning Device for a Laboratory Apparatus for the Distribution of Fluid Samples, Laboratory Apparatus with a Positioning Device and Positioning Method |
| CN109317231A (en) * | 2018-12-06 | 2019-02-12 | 佛山科学技术学院 | A kind of automatic biological reagent handling device |
| CN213995929U (en) * | 2020-11-27 | 2021-08-20 | 伊艾博(武汉)科技股份有限公司 | Small-size high-efficient liquid-transfering work station |
| CN217221544U (en) * | 2022-03-22 | 2022-08-19 | 英诺维尔智能科技（苏州）有限公司 | Desktop automatic pipetting device with 96 independent pipetting channels |
-
2022
- 2022-10-18 CN CN202211275757.2A patent/CN115445682A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110268627A1 (en) * | 2010-05-03 | 2011-11-03 | Integra Biosciences Corp. (Formerly Viaflo Corporation) | Manually Directed, Multi-Channel Electronic Pipetting System |
| US20130047751A1 (en) * | 2011-07-26 | 2013-02-28 | Eppendorf Ag | Positioning Device for a Laboratory Apparatus for the Distribution of Fluid Samples, Laboratory Apparatus with a Positioning Device and Positioning Method |
| CN109317231A (en) * | 2018-12-06 | 2019-02-12 | 佛山科学技术学院 | A kind of automatic biological reagent handling device |
| CN213995929U (en) * | 2020-11-27 | 2021-08-20 | 伊艾博(武汉)科技股份有限公司 | Small-size high-efficient liquid-transfering work station |
| CN217221544U (en) * | 2022-03-22 | 2022-08-19 | 英诺维尔智能科技（苏州）有限公司 | Desktop automatic pipetting device with 96 independent pipetting channels |
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