CN115427453A - Cldn18.2抗体及其用途 - Google Patents

Cldn18.2抗体及其用途 Download PDF

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Publication number
CN115427453A
CN115427453A CN202180013663.5A CN202180013663A CN115427453A CN 115427453 A CN115427453 A CN 115427453A CN 202180013663 A CN202180013663 A CN 202180013663A CN 115427453 A CN115427453 A CN 115427453A
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China
Prior art keywords
antibody
seq
cells
cancer
antigen
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Pending
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CN202180013663.5A
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English (en)
Inventor
周清
许传营
粘伟红
何向宇
张新敏
郑欣桐
何峰
肖婧
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Shanghai Shijian Biotechnology Co ltd
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Shanghai Shijian Biotechnology Co ltd
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Publication of CN115427453A publication Critical patent/CN115427453A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Abstract

提供了一种密蛋白18.2(CLDN18.2)的抗体，及其在诊断和治疗胃、胰腺、食管癌症中的用途。

Description

PCT国内申请，说明书已公开。

Claims (33)

  1. PCT国内申请，权利要求书已公开。
CN202180013663.5A 2020-02-10 2021-02-10 Cldn18.2抗体及其用途 Pending CN115427453A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020100844763 2020-02-10
CN202010084476 2020-02-10
PCT/CN2021/076481 WO2021160154A1 (zh) 2020-02-10 2021-02-10 Cldn18.2抗体及其用途

Publications (1)

Publication Number Publication Date
CN115427453A true CN115427453A (zh) 2022-12-02

Family

ID=77292052

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180013663.5A Pending CN115427453A (zh) 2020-02-10 2021-02-10 Cldn18.2抗体及其用途

Country Status (8)

Country Link
US (1) US20230312704A1 (zh)
EP (1) EP4105237A4 (zh)
JP (1) JP2023513400A (zh)
KR (1) KR20220139357A (zh)
CN (1) CN115427453A (zh)
AU (1) AU2021220887A1 (zh)
CA (1) CA3167299A1 (zh)
WO (1) WO2021160154A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117551199A (zh) * 2023-11-16 2024-02-13 杭州荣谷生物科技有限公司 一种Claudin18.2纳米抗体的制备方法及其应用
CN117551199B (zh) * 2023-11-16 2024-04-19 杭州荣谷生物科技有限公司 一种Claudin18.2纳米抗体的制备方法及其应用

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* Cited by examiner, † Cited by third party
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EP4349371A1 (en) 2021-06-02 2024-04-10 Bio-Thera Solutions, Ltd. Drug conjugate and use thereof
WO2023196882A1 (en) * 2022-04-06 2023-10-12 Zai Lab (Us) Llc Claudin 18.2 immunohistochemistry assay and use thereof

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CN110606891A (zh) * 2018-06-17 2019-12-24 上海健信生物医药科技有限公司 一种针对人cldn18.2的新型抗体分子, 抗原结合片段及其医药用途
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CN104321345A (zh) * 2012-05-09 2015-01-28 加尼梅德药物公司 用于癌症诊断的针对密蛋白18.2的抗体
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WO2019219089A1 (en) * 2018-05-18 2019-11-21 Bridge Health Bio-Tech Co., Ltd Anti-claudin 18.2 antibodies and uses thereof
CN110606891A (zh) * 2018-06-17 2019-12-24 上海健信生物医药科技有限公司 一种针对人cldn18.2的新型抗体分子, 抗原结合片段及其医药用途
WO2020018852A2 (en) * 2018-07-18 2020-01-23 Askgene Pharma Inc. Novel antibodies and methods for making and using the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117551199A (zh) * 2023-11-16 2024-02-13 杭州荣谷生物科技有限公司 一种Claudin18.2纳米抗体的制备方法及其应用
CN117551199B (zh) * 2023-11-16 2024-04-19 杭州荣谷生物科技有限公司 一种Claudin18.2纳米抗体的制备方法及其应用

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Publication number Publication date
EP4105237A1 (en) 2022-12-21
WO2021160154A1 (zh) 2021-08-19
KR20220139357A (ko) 2022-10-14
US20230312704A1 (en) 2023-10-05
CA3167299A1 (en) 2021-08-19
EP4105237A4 (en) 2024-03-27
JP2023513400A (ja) 2023-03-30
AU2021220887A1 (en) 2022-09-29

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