CN115252908A - Preparation method of composite porous titanium scaffold for increasing new bone ingrowth - Google Patents
Preparation method of composite porous titanium scaffold for increasing new bone ingrowth Download PDFInfo
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- CN115252908A CN115252908A CN202211085302.4A CN202211085302A CN115252908A CN 115252908 A CN115252908 A CN 115252908A CN 202211085302 A CN202211085302 A CN 202211085302A CN 115252908 A CN115252908 A CN 115252908A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/427—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Abstract
The invention discloses a preparation method of a composite porous titanium bracket for increasing new bone ingrowth, which comprises the steps of mixing and stirring alpha-calcium sulfate hemihydrate and deionized water to obtain bone cement, filling the bone cement into the porous titanium bracket to obtain a composite material, drying the composite material, and removing a detailed protruding part to obtain a regular composite porous titanium bracket; the composite porous titanium scaffold has the advantages of inductivity and osteoconductivity, and as the alpha-calcium sulfate hemihydrate is degraded, new bones completely replace the alpha-calcium sulfate hemihydrate to fill gaps of the porous titanium, so that firm growth is realized, the combination of the contact surfaces of the bones and the implant is enhanced, and the composite porous titanium scaffold is particularly suitable for patients with impaired bone growth capacity; the alpha-calcium sulfate hemihydrate prepared by the steps of the invention has simple whole preparation conditions, mild reaction and no high temperature or harmful substances; in addition, the biological activator has good biocompatibility, namely no cytotoxicity, can not damage the existing cells, and can not inhibit the growth of the cells.
Description
Technical Field
The invention relates to the technical field of biomedical materials, in particular to a preparation method of a composite porous titanium scaffold for increasing new bone ingrowth.
Background
A large number of skeletal trauma and defect cases are caused annually due to various reasons such as traffic accidents, diseases and the like, when large-area bone defects occur, the two ends of the fracture cannot be fixedly butted, the skeletal repair fails, and the conditions of nonunion or deformed healing and the like occur. Bone repair material filling is needed at this time to help connect and reconstruct the bone structure and promote bone formation; with the aging population, the demand of people for joint replacement is continuously increasing, and the service life of the existing prosthesis is limited, so that the number of renovations is greatly increased.
In the joint replacement revision surgery, a great amount of bone loss caused by prosthesis removal cannot provide a growth space for host bones after bone cement is used for filling a bone-prosthesis contact surface. In addition, complex joint diseases are often accompanied by the following basic diseases: the bone growth ability of patients with diabetes, osteoporosis and non-steroidal drugs is impaired by long-term users, and the implanted prosthesis lacks materials inducing osteogenesis, so that the prosthesis is not firmly combined with human tissues, the service life of the prosthesis is short, the repair rate is high, heavy economic burden is brought to the patients, and pains are brought to the bodies of the patients.
Disclosure of Invention
Aiming at the technical problem that the traditional prosthesis lacks osteoinductivity and osteoconductivity, so that the combination between the prosthesis and human tissues of a patient with impaired bone growth capacity is not firm, the invention provides a preparation method of a composite porous titanium scaffold for increasing new bone ingrowth.
The technical scheme adopted by the invention is as follows: the preparation method of the composite porous titanium scaffold with new bone growth is added, alpha-calcium sulfate hemihydrate and deionized water are mixed and stirred to obtain bone cement, the bone cement is filled into the porous titanium scaffold to obtain a composite material, and then the composite material is dried to remove the detailed protruding part to obtain the regular composite porous titanium scaffold.
The porous titanium is used as an inert metal, does not release harmful metal ions in vivo, has mechanical strength similar to human skeleton, high porosity and proper pore size, and is very suitable for bone defect repair. However, the situation of new bone growth of pure porous titanium is still not ideal, bone cells cannot grow into pores as much as possible, gaps of the porous titanium are filled, and osteoinductivity and osteoconductivity are poor. Therefore, the invention fills the pores of the porous titanium with the bone cement mixed by alpha-calcium sulfate hemihydrate and deionized water. Calcium sulfate hemihydrate can be the mainstream bone substitute material in calcium sulfate because of its relatively appropriate degradation rate and stability. The alpha-calcium sulfate hemihydrate is a hexagonal crystal system, has low crystal length-diameter ratio, large size and relatively stable crystal form, and is particularly suitable for bone substitute materials. After the composite porous titanium scaffold is placed into a human body, calcium ions and sulfate ions generated when alpha-calcium sulfate hemihydrate is degraded in vivo are important components for bone formation, and extracellular high-concentration calcium ions inhibit bone marrow mesenchymal stem cells from differentiating to osteoclasts so as to promote the differentiation of the bone marrow mesenchymal stem cells to osteoblasts; meanwhile, the proliferation of osteoblasts is promoted, the osteoblasts are induced to migrate to a bone reconstruction region, the activity of alkaline phosphatase is improved, and the bone ingrowth capacity is further improved. The porous titanium has the advantages of osteoinductivity and osteoconductivity, and as the alpha-calcium sulfate hemihydrate is degraded, new bones completely replace the alpha-calcium sulfate hemihydrate to fill gaps of the porous titanium, so that firm growth is realized, and the combination of the contact surface of the bones and the implant is enhanced.
Furthermore, the ratio of the deionized water to the alpha-calcium sulfate hemihydrate is 0.25-0.45. The self-curing property is an important characteristic of the artificial bone repair material, the alpha-calcium sulfate hemihydrate has the self-curing property, and the deionized water is used as a curing liquid. Another important characteristic of the artificial bone repair material is a reasonable setting time, and the deionized water and the alpha-calcium sulfate hemihydrate are mixed in different proportions, and the setting times are different, and the inventor of the present application preferably selects that the ratio of the deionized water to the alpha-calcium sulfate hemihydrate is 0.25 to 0.45 based on a large number of experiments.
Furthermore, the porous titanium support is made by selective laser sintering, and has the advantages of simple manufacturing process, high flexibility, wide material selection range, low material price, low cost, high material utilization rate, high forming speed and the like.
Furthermore, the porosity of the porous titanium scaffold is 70-80%, and the selection of the porosity range is also a great deal of practice of the inventor, and in practice, it is found that too high porosity affects the strength of the porous titanium scaffold, and too low porosity affects the bonding of the bone and the contact surface of the porous titanium scaffold, and finally the porosity is preferably 70-80%.
Furthermore, the aperture in the porous titanium bracket is 200-600 μm. The invention controls the aperture range of the porous titanium, which is most beneficial to the growth of fibers, blood vessels and cells.
Further, in each step:
s1, adding 36-44 parts of powdered calcium sulfate dihydrate and 90-110 parts of deionized water into a container, mixing and stirring, adding 0.14-0.16 part of sodium acetate and 3-3.6 parts of calcium chloride into the container, mixing and stirring, placing the container into a high-pressure steam sterilizer, and dissolving and recrystallizing the calcium sulfate dihydrate to form calcium sulfate hemihydrate crystals;
s2, putting the calcium sulfate hemihydrate crystal prepared in the step S1 into an electric heating air blowing drying oven for drying treatment;
s3, taking out crystals from the electric heating air drying box, grinding the crystals to obtain white powdery alpha-calcium sulfate hemihydrate, and storing the white powdery alpha-calcium sulfate hemihydrate in a normal-temperature drying place for later use;
s4, mixing and stirring the alpha-calcium sulfate hemihydrate prepared in the step S3 with deionized water to obtain bone cement, and filling the bone cement into the porous titanium support to obtain a composite material;
and S5, drying the composite material prepared in the step S4, and removing the detailed protruding part to obtain the regular composite porous titanium support.
There are many ways in the prior art to prepare calcium sulfate alpha-hemihydrate, for example, phosphogypsum is used as raw material and sodium sulfate is used as crystal transformation agent to prepare calcium sulfate alpha-hemihydrate; adding a calcium acetate solution into a reaction bottle, heating to a certain temperature, adding sodium sulfate into the reaction bottle, carrying out heat preservation reaction, filtering to obtain a calcium sulfate wet product and a calcium sulfate mother liquor, and carrying out airflow drying on the wet product at 100 ℃ to obtain alpha-calcium sulfate hemihydrate powder. However, these methods have the following disadvantages: complex preparation conditions, large energy consumption, inconvenient material obtaining, generation of toxic or difficultly-treated substances in the preparation process, low purity and the like. Based on the defects of the prior art, the alpha-calcium sulfate hemihydrate prepared by the steps of the invention has the advantages of simple whole preparation conditions, mild reaction, easily obtained materials, low energy consumption and no generation of high temperature or harmful substances. In addition, the biological activity inhibitor has good biocompatibility, namely, no cytotoxicity exists, the existing cells cannot be damaged, and the growth of the cells cannot be inhibited; appropriate biodegradability, both degradable and absorbable, to coordinate the rate of degradation with the rate of new osteogenesis; excellent osteoconductivity and osteoinductivity.
Further, in the step S1, the temperature in the high-pressure steam sterilizer is 120-140 ℃, and the reaction time is 1.5-2.5 h.
Further, in the step S2, the temperature in the electric heating air blowing drying oven is 100-120 ℃, and the drying time is 24-30 h.
Further, in the step S2, when the calcium sulfate hemihydrate crystal is dried in the electric heating blowing dry box, the vacuum filtration and the washing treatment with boiling water are sequentially carried out for 3 to 4 times under a hot state. The purpose of this step is to wash away excess crystal form conversion agent, making the prepared alpha-calcium sulfate hemihydrate powder more pure.
Furthermore, in the step S4, powdery alpha-calcium sulfate hemihydrate with the particle size range of 40-100 μm is selected. The inventor finds that the alpha-calcium sulfate hemihydrate with different particle sizes can influence the performance of the composite porous titanium scaffold on the basis of a large number of experiments, and the alpha-calcium sulfate hemihydrate with overlarge particle size contains more impurities and low purity due to large block heads, so that the combination between the composite porous titanium scaffold and human tissues can be influenced; when the particle size is too small, the bone cement filled into the porous titanium scaffold is influenced by pressure in the process of placing the composite porous titanium scaffold into a human body, and small alpha-calcium sulfate hemihydrate can be diffused into blood and circulate into the lung along with the blood to cause embolism, so that pain and unnecessary economic burden are brought to a patient. For this reason, the preferred particle size range for the calcium sulfate alpha-hemihydrate of the present invention is from 40 μm to 100 μm, based on a number of experiments.
The invention has the beneficial effects that:
1. the composite porous titanium scaffold has the advantages of inductivity and osteoconductivity, and as the alpha-calcium sulfate hemihydrate is degraded, new bones completely replace the alpha-calcium sulfate hemihydrate to fill gaps of the porous titanium finally, so that firm growth is realized, the combination of the contact surfaces of the bones and the implant is enhanced, and the composite porous titanium scaffold is particularly suitable for patients with impaired bone growth capacity.
2. The invention takes the porous titanium as the base and controls the aperture range of the porous titanium, and the range is most beneficial to the growth of fibers, blood vessels and cells.
3. The alpha-calcium sulfate hemihydrate prepared by the steps of the invention has the advantages of simple whole preparation conditions, mild reaction, easily obtained materials, low energy consumption and no generation of high temperature or harmful substances; in addition, the biological preservative also has good biocompatibility, namely no cytotoxicity, no damage to the existing cells and no inhibition of the growth of the cells; suitable biodegradability is both degradable and absorbable, and allows the rate of degradation to be coordinated with the rate of new bone formation.
Drawings
FIG. 1 is a graph of the initial set time and final set time for different solid to liquid ratios of alpha calcium sulfate hemihydrate to deionised.
Fig. 2 shows the weight loss of bone cement at different liquid-solid ratios.
Detailed Description
The invention is further described below with reference to the accompanying drawings.
Example one
The preparation method of the composite porous titanium scaffold for increasing the growth of new bones comprises the following steps:
s1, adding 40 parts of powdered calcium sulfate dihydrate and 100 parts of deionized water into a container, mixing and stirring, adding 0.15 part of sodium acetate and 3.3 parts of calcium chloride into the container, mixing and stirring, placing the container into a high-pressure steam sterilizer, setting the temperature at 130 ℃, reacting for 2 hours, and dissolving and recrystallizing the calcium sulfate dihydrate to form calcium sulfate hemihydrate crystals;
s2, drying the calcium sulfate hemihydrate crystal prepared in the step S1 in an electric heating forced air drying oven, wherein the temperature in the electric heating forced air drying oven is 110 ℃, and the drying time is 24 hours;
s324h, taking out crystals from the electrothermal blowing drying box, grinding the crystals to obtain white powdery alpha-calcium sulfate hemihydrate, selecting powdery alpha-calcium sulfate hemihydrate with the particle size range of 40-100 mu m after the particle size of the crystals is screened by an analysis sieve, and storing the white powdery alpha-calcium sulfate hemihydrate in a room-temperature drying place for later use;
s4, mixing and stirring the alpha-calcium sulfate hemihydrate prepared in the step S3 with deionized water to obtain bone cement, and filling the bone cement into the porous titanium support to obtain a composite material; the proportion of the deionized water to the alpha-calcium sulfate hemihydrate is 1g;
and S5, drying the composite material prepared in the step S4, and removing the detailed protruding part to obtain the regular composite porous titanium support.
Example two
In this example, the ratio of deionized water to calcium sulfate alpha-hemihydrate in step S4 is different, and the other conditions are the same, and the ratio of deionized water to calcium sulfate alpha-hemihydrate in this example is 1 g.
EXAMPLE III
In the embodiment, the ratio of the deionized water to the alpha-calcium sulfate hemihydrate in the step S4 is different, and the other conditions are the same, and the ratio of the deionized water to the alpha-calcium sulfate hemihydrate in the embodiment is 1g.
Example four
In the embodiment, the ratio of the deionized water to the alpha-calcium sulfate hemihydrate in the step S4 is different, and the other conditions are the same, and the ratio of the deionized water to the alpha-calcium sulfate hemihydrate in the embodiment is 1g.
EXAMPLE five
In this example, the ratio of deionized water to α -calcium sulfate hemihydrate in step S4 is different, and the other conditions are the same, and the ratio of deionized water to α -calcium sulfate hemihydrate in this example is 1g.
Setting time experiment of alpha-calcium sulfate hemihydrate:
self-curing is an important characteristic of the artificial bone repair material, and the alpha-calcium sulfate hemihydrate has self-curing property. Meanwhile, another important characteristic of the artificial bone repair material is a reasonable curing time. The setting time of the artificial bone repair material can be divided into an initial setting time (T1) and a final setting Time (TF). According to clinical observations and clinician requirements, khairoun sets forth a widely clinically accepted standard for setting time for artificial bone repair materials: the method comprises the steps of enabling T1 to be more than or equal to T3 min and less than or equal to T1 min; the T1-Tc is more than or equal to 1min; the TF is less than or equal to 15min. Where Tc is the binding time, i.e. the time between the start of mixing of the two phases, solid and liquid, and the moment when the mixture is in contact with the liquid and no longer thins out. The initial setting time and the final setting time of the alpha-calcium sulfate hemihydrate are influenced by the temperature and the humidity of a curing environment, a curing liquid, a liquid-solid ratio and other factors. In the research, the environmental temperature is 25 ℃, the air humidity is 80%, the curing liquid is deionized water, and the alpha-calcium sulfate hemihydrate powder and the deionized water are divided into 5 groups according to different proportions. The setting time of the alpha-calcium sulfate hemihydrate is shown in table 1 and fig. 1 under different liquid-solid ratio conditions.
Table 1: setting time (min, X +/-s) of alpha-calcium sulfate hemihydrate solidified by different liquid-solid ratios
| Liquid-solid ratio | Shape of | Initial setting time | Final setting time | Whether or not to meet the standard | |
| Example one | 0.2 | Dough shape | 1.7±0.3 | 6.1±1.1 | Is not in compliance with |
| Example two | 0.25 | Paste-like | 2.6±0.8 | 7.7±1.8 | Non-conforming to |
| EXAMPLE III | 0.3 | Paste-like | 3.3±1.4 | 8.4±2.0 | Conform to |
| Example four | 0.4 | Paste-like | 5.9±1.9 | 13.9±3.2 | Meet with |
| EXAMPLE five | 0.5 | Paste-like | 6.6±1.8 | 16.9±3.5 | Is not in compliance with |
It can be seen that the setting time (initial setting time, final setting time) of the calcium sulfate alpha-hemihydrate is prolonged as the setting liquid content ratio is increased. When the liquid-solid ratio is 0.2, the initial setting time is 1.7 +/-0.3 min, and the final setting time is 6.1 +/-1.1 min; when the liquid-solid ratio is increased to 0.5, the initial setting time is 6.6 +/-1.9 min, and the final setting time is 16.9 +/-3.5 min. In conclusion, the bone cements prepared in example three and example four meet the standards. For this reason, the preferred ratio of deionized water to alpha calcium sulfate hemihydrate of the present invention is 0.25 to 0.45.
Degradability test of alpha-calcium sulfate hemihydrate:
the proportion of the alpha-calcium sulfate hemihydrate powder to the deionized water is respectively as follows: 1g. When the liquid-solid ratio is 0.2, the weight loss rate is 50.7% +/-2.5%, and when the liquid-solid ratio is 0.5, the weight loss rate is increased to 58.3% +/-2.4%, so that the degradation rate of the alpha-calcium sulfate hemihydrate bone cement is gradually increased along with the increase of the liquid-solid ratio.
In vivo experiments
Group 1 (blank group): only punching holes and not implanting the porous titanium stent;
group 2 (control group): a porous titanium scaffold unfilled with alpha-calcium sulfate hemihydrate;
group 3 (experimental group): composite porous titanium scaffolds prepared in example three;
the experimental conditions are as follows: implanting the 3 prepared porous titanium stents into femoral condyles of rabbits, euthanizing the rabbits after 4 weeks, taking out the porous titanium and surrounding bone tissues, fixing, eluting, embedding, preparing slices, performing Micro-CT scanning, and evaluating the new bone ingrowth condition.
The experimental results are as follows: the percent bone in growth was 15%, 35%, 76% for group 1 (blank), group 2 (control) and group 3 (experimental), respectively.
The experimental conclusion is that: the group 3 (experimental group) is more than 2 times of the group 2 (control group) for new bone ingrowth and 5 times of the group 1 (blank group), thereby greatly increasing the bone ingrowth capacity.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (10)
1. The preparation method of the composite porous titanium scaffold with new bone growth is characterized in that alpha-calcium sulfate hemihydrate and deionized water are mixed and stirred to obtain bone cement, the bone cement is filled into the porous titanium scaffold to obtain a composite material, and then the composite material is dried to remove the detailed protruding part to obtain the regular composite porous titanium scaffold.
2. The method for preparing a composite porous titanium scaffold for increasing new bone in-growth according to claim 1, wherein the ratio of the deionized water to the alpha-calcium sulfate hemihydrate is 0.25-0.45.
3. The method of preparing a composite porous titanium scaffold that increases new bone in-growth according to claim 1, wherein said porous titanium scaffold is made by selective laser sintering.
4. The method for preparing a composite porous titanium scaffold for increasing new bone in-growth according to claim 1, wherein the porosity of the porous titanium scaffold is 70% to 80%.
5. The method for preparing a composite porous titanium scaffold for increasing the ingrowth of new bone according to claim 1, wherein the pore size in said porous titanium scaffold is 200 μm to 600 μm.
6. The method for preparing a composite porous titanium scaffold for increasing new bone in-growth according to claim 1, wherein in the steps:
s1, adding 36-44 parts of powdered calcium sulfate dihydrate and 90-110 parts of deionized water into a container, mixing and stirring, adding 0.14-0.16 part of sodium acetate and 3-3.6 parts of calcium chloride into the container, mixing and stirring, placing the container into a high-pressure steam sterilizer, and dissolving and recrystallizing the calcium sulfate dihydrate to form calcium sulfate hemihydrate crystals;
s2, placing the calcium sulfate hemihydrate crystal prepared in the step S1 into an electric heating air blowing drying oven for drying treatment;
s3, taking out the crystal from the electric heating air blast drying box, grinding to obtain white powdery alpha-calcium sulfate hemihydrate, and storing the white powdery alpha-calcium sulfate hemihydrate in a normal-temperature drying place for later use;
s4, mixing and stirring the alpha-calcium sulfate hemihydrate prepared in the step S3 with deionized water to obtain bone cement, and filling the bone cement into the porous titanium support to obtain a composite material;
and S5, drying the composite material prepared in the step S4, and removing the detailed protruding parts to obtain the regular composite porous titanium scaffold.
7. The method for preparing a composite porous titanium scaffold for increasing the ingrowth of new bone according to claim 6, wherein in said step S1, the temperature in the autoclave is 120 to 140 ℃ and the reaction time is 1.5 to 2.5 hours.
8. The method for preparing a composite porous titanium scaffold for increasing the ingrowth of new bones according to claim 6, wherein in the step S2, the temperature in the electrothermal blowing dry box is 100-120 ℃ and the drying time is 24-30 h.
9. The method for preparing a composite porous titanium scaffold with increased new bone ingrowth according to claim 6, wherein in the step S2, the calcium sulfate hemihydrate crystals are sequentially subjected to suction filtration and boiling water washing for 3 to 4 times in a hot state while being dried in an electric hot blast drying oven.
10. The method for preparing a composite porous titanium scaffold for increasing the in-growth of new bone according to claim 6, wherein in the step S4, the powdered alpha-calcium sulfate hemihydrate having a particle size ranging from 40 μm to 100 μm is selected.
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