CN115251053B - 一种香紫苏醇植物抗病毒制剂及其应用 - Google Patents
一种香紫苏醇植物抗病毒制剂及其应用 Download PDFInfo
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- CN115251053B CN115251053B CN202210845071.6A CN202210845071A CN115251053B CN 115251053 B CN115251053 B CN 115251053B CN 202210845071 A CN202210845071 A CN 202210845071A CN 115251053 B CN115251053 B CN 115251053B
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- sclareol
- plant
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- antiviral preparation
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- XVULBTBTFGYVRC-HHUCQEJWSA-N sclareol Chemical compound CC1(C)CCC[C@]2(C)[C@@H](CC[C@](O)(C)C=C)[C@](C)(O)CC[C@H]21 XVULBTBTFGYVRC-HHUCQEJWSA-N 0.000 title claims abstract description 150
- XVULBTBTFGYVRC-UHFFFAOYSA-N Episclareol Natural products CC1(C)CCCC2(C)C(CCC(O)(C)C=C)C(C)(O)CCC21 XVULBTBTFGYVRC-UHFFFAOYSA-N 0.000 title claims abstract description 75
- LAEIZWJAQRGPDA-UHFFFAOYSA-N Manoyloxid Natural products CC1(C)CCCC2(C)C3CC=C(C)OC3(C)CCC21 LAEIZWJAQRGPDA-UHFFFAOYSA-N 0.000 title claims abstract description 75
- 238000002360 preparation method Methods 0.000 title claims abstract description 42
- 230000000840 anti-viral effect Effects 0.000 title claims abstract description 25
- 241000196324 Embryophyta Species 0.000 claims abstract description 41
- 241000700605 Viruses Species 0.000 claims abstract description 24
- 244000061176 Nicotiana tabacum Species 0.000 claims abstract description 23
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims abstract description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 241000723762 Potato virus Y Species 0.000 claims abstract description 11
- 150000002191 fatty alcohols Chemical class 0.000 claims abstract description 9
- 229940051841 polyoxyethylene ether Drugs 0.000 claims abstract description 9
- 229920000056 polyoxyethylene ether Polymers 0.000 claims abstract description 9
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 7
- 240000008067 Cucumis sativus Species 0.000 claims abstract description 5
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims abstract description 5
- 201000010099 disease Diseases 0.000 claims description 31
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 31
- 238000003756 stirring Methods 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 5
- 239000008367 deionised water Substances 0.000 claims description 2
- 229910021641 deionized water Inorganic materials 0.000 claims description 2
- 239000008399 tap water Substances 0.000 claims description 2
- 235000020679 tap water Nutrition 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 24
- 230000002265 prevention Effects 0.000 abstract description 13
- 239000003995 emulsifying agent Substances 0.000 abstract description 3
- 239000012752 auxiliary agent Substances 0.000 abstract description 2
- 231100000053 low toxicity Toxicity 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000004530 micro-emulsion Substances 0.000 abstract description 2
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
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- 238000012360 testing method Methods 0.000 description 17
- 239000000243 solution Substances 0.000 description 10
- 238000011081 inoculation Methods 0.000 description 8
- 238000011160 research Methods 0.000 description 8
- 241000723873 Tobacco mosaic virus Species 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 238000002161 passivation Methods 0.000 description 5
- 239000003085 diluting agent Substances 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
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- 238000011835 investigation Methods 0.000 description 3
- 230000003716 rejuvenation Effects 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000724252 Cucumber mosaic virus Species 0.000 description 2
- 241000221785 Erysiphales Species 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- 102000003777 Interleukin-1 beta Human genes 0.000 description 2
- 108090000193 Interleukin-1 beta Proteins 0.000 description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
- 241001477931 Mythimna unipuncta Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 244000061456 Solanum tuberosum Species 0.000 description 2
- 235000002595 Solanum tuberosum Nutrition 0.000 description 2
- 241000607479 Yersinia pestis Species 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000531 effect on virus Effects 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
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- 239000013642 negative control Substances 0.000 description 2
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 244000020518 Carthamus tinctorius Species 0.000 description 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 description 1
- 241001115402 Ebolavirus Species 0.000 description 1
- 241000711950 Filoviridae Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 206010061217 Infestation Diseases 0.000 description 1
- 208000003947 Knee Osteoarthritis Diseases 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 241001115401 Marburgvirus Species 0.000 description 1
- 241001495644 Nicotiana glutinosa Species 0.000 description 1
- IMKJGXCIJJXALX-SHUKQUCYSA-N Norambreinolide Chemical compound CC([C@@H]1CC2)(C)CCC[C@]1(C)[C@@H]1[C@]2(C)OC(=O)C1 IMKJGXCIJJXALX-SHUKQUCYSA-N 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000221535 Pucciniales Species 0.000 description 1
- 241000256251 Spodoptera frugiperda Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
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- 230000002776 aggregation Effects 0.000 description 1
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 1
- 210000001264 anterior cruciate ligament Anatomy 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008355 cartilage degradation Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 239000007957 coemulsifier Substances 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
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- 230000006806 disease prevention Effects 0.000 description 1
- IMKJGXCIJJXALX-UHFFFAOYSA-N ent-Norambreinolide Natural products C1CC2C(C)(C)CCCC2(C)C2C1(C)OC(=O)C2 IMKJGXCIJJXALX-UHFFFAOYSA-N 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- -1 lactone compounds Chemical class 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000005648 plant growth regulator Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000012372 quality testing Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 229940096995 sclareolide Drugs 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- DAJSVUQLFFJUSX-UHFFFAOYSA-M sodium;dodecane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCS([O-])(=O)=O DAJSVUQLFFJUSX-UHFFFAOYSA-M 0.000 description 1
- 230000004763 spore germination Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/06—Oxygen or sulfur directly attached to a cycloaliphatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Toxicology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
序号 | 香紫苏醇浸膏% | 乙醇% | 脂肪醇聚氧乙烯醚% | 十二烷基磺酸钠 | 水% |
1 | 8% | 25% | 15% | 6% | 余量 |
2 | 9% | 30% | 20% | 7% | 余量 |
3 | 10% | 35% | 25% | 8% | 余量 |
质量技术指标 | 测定值 | 检测方法 |
透明温度范围 | -4℃-60℃ | 冰箱、水浴检测 |
微乳剂稳定性 | 合格 | GB/T1603 |
PH值 | 7.0 | GB/T1601 |
低温稳定性(0℃±1℃下贮存14d) | 合格 | GB/T19137, |
热贮稳定性(50℃±2℃下贮存14d) | 合格 | GB/T19136 |
Claims (5)
Priority Applications (1)
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CN202210845071.6A CN115251053B (zh) | 2022-07-19 | 2022-07-19 | 一种香紫苏醇植物抗病毒制剂及其应用 |
Applications Claiming Priority (1)
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CN202210845071.6A CN115251053B (zh) | 2022-07-19 | 2022-07-19 | 一种香紫苏醇植物抗病毒制剂及其应用 |
Publications (2)
Publication Number | Publication Date |
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CN115251053A CN115251053A (zh) | 2022-11-01 |
CN115251053B true CN115251053B (zh) | 2023-09-26 |
Family
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CN202210845071.6A Active CN115251053B (zh) | 2022-07-19 | 2022-07-19 | 一种香紫苏醇植物抗病毒制剂及其应用 |
Country Status (1)
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CN (1) | CN115251053B (zh) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011246447A (ja) * | 2010-04-26 | 2011-12-08 | National Institute Of Agrobiological Sciences | 植物病害防除剤および植物病害防除方法 |
CN103120189A (zh) * | 2013-02-06 | 2013-05-29 | 杨凌农科大无公害农药研究服务中心 | 一种粗榧抗植物病毒剂及其制备方法 |
CN103766414A (zh) * | 2014-01-08 | 2014-05-07 | 杨凌农科大无公害农药研究服务中心 | 一种含余甘子植物源抗病毒剂及其制备方法 |
CN104738102A (zh) * | 2015-03-26 | 2015-07-01 | 杨凌农科大无公害农药研究服务中心 | 中华猕猴桃根皮提取物用于制备抗植物病毒剂的应用 |
CN111265502A (zh) * | 2018-12-05 | 2020-06-12 | 中国医学科学院药物研究所 | 香紫苏醇和香紫苏内酯在抗丝状病毒感染中的应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210378238A1 (en) * | 2018-10-21 | 2021-12-09 | Grace Breeding Ltd. | Dual-route administration of composition for improved protection of plants against pathogens |
-
2022
- 2022-07-19 CN CN202210845071.6A patent/CN115251053B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011246447A (ja) * | 2010-04-26 | 2011-12-08 | National Institute Of Agrobiological Sciences | 植物病害防除剤および植物病害防除方法 |
CN103120189A (zh) * | 2013-02-06 | 2013-05-29 | 杨凌农科大无公害农药研究服务中心 | 一种粗榧抗植物病毒剂及其制备方法 |
CN103766414A (zh) * | 2014-01-08 | 2014-05-07 | 杨凌农科大无公害农药研究服务中心 | 一种含余甘子植物源抗病毒剂及其制备方法 |
CN104738102A (zh) * | 2015-03-26 | 2015-07-01 | 杨凌农科大无公害农药研究服务中心 | 中华猕猴桃根皮提取物用于制备抗植物病毒剂的应用 |
CN111265502A (zh) * | 2018-12-05 | 2020-06-12 | 中国医学科学院药物研究所 | 香紫苏醇和香紫苏内酯在抗丝状病毒感染中的应用 |
Non-Patent Citations (1)
Title |
---|
Discovery of sclareol and sclareolide as filovirus entry inhibitors;Qing Chen;Journal of Asian Natural Products Research;第22卷(第2期);第464-473页 * |
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Inventor after: Liu Yanhua Inventor after: Du Yongmei Inventor after: Zhang Hongbo Inventor after: Qi Chaofan Inventor after: Shen Lili Inventor after: Dou Yuqing Inventor after: Han Xiao Inventor after: Zhang Jianhui Inventor after: Yang Xingyou Inventor before: Liu Yanhua Inventor before: Du Yongmei Inventor before: Zhang Hongbo Inventor before: Qi Chaofan Inventor before: Shen Lili Inventor before: Dou Yuqing Inventor before: Han Xiao |
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Effective date of registration: 20240110 Address after: Unit 1, building 1, No. 936, shijicheng Road, high tech Zone, Chengdu, Sichuan 610000 Patentee after: CHINA NATIONAL TOBACCO CORPORATION SICHUAN Patentee after: INSTITUTE OF TOBACCO RESEARCH OF CAAS, QINGZHOU TOBACCO RESEARCH INSTITUTE OF CHINA NATIONAL TOBACCO Co. Address before: 266000 Shandong Province, Qingdao city Laoshan District Four Keyuan Road No. 11 Patentee before: INSTITUTE OF TOBACCO RESEARCH OF CAAS, QINGZHOU TOBACCO RESEARCH INSTITUTE OF CHINA NATIONAL TOBACCO Co. |