CN115243553A - 用于制备可饮用产品的粉末组合物 - Google Patents

用于制备可饮用产品的粉末组合物 Download PDF

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CN115243553A
CN115243553A CN202180020598.9A CN202180020598A CN115243553A CN 115243553 A CN115243553 A CN 115243553A CN 202180020598 A CN202180020598 A CN 202180020598A CN 115243553 A CN115243553 A CN 115243553A
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concentrate
extract
composition
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罗尔夫·索尔格
托拜厄斯·冠利
威廉·梅塞尔
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PM International AG
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract

本申请涉及一种用于制备口服溶液的粉末组合物，其中该组合物每100g含有1g至85g的至少一种单糖、0.18g至0.70g的至少一种甜菊糖苷、1.5g至10g柠檬酸、0.3g至3g维生素C、至少两种其他维生素，以及绿茶(Camelliasinensis)提取物。

Description

用于制备可饮用产品的粉末组合物
技术领域
本申请涉及营养补充剂，尤其涉及一种用于制备口服溶液的粉末组合物，以及本申请的用于制备口服溶液的组合物的用途。
背景技术
营养补充剂通常口服给药。为了改善胃肠道对有价值成分的吸收，简化营养补充剂的摄入，并避免摄入过程中的并发症，这些营养补充剂通常以水溶液形式服用。为了减少微生物侵染和增加化学稳定性，为此目的营养补充剂通常以泡腾片或粉剂的形式提供，然后由使用者将其分散在水中以形成可口服的溶液。
在许多情况下，成分的溶解行为、溶液的视觉外观和味道都存在不足。在许多营养补充剂中，不能令人满意的还有一点，即有价值成分的生物利用度不足。一般来说，常规营养补充剂的化学稳定性和微生物稳定性也有改善空间。因此，需要改进的营养补充剂。
营养补充剂也用来改善肌肉和神经细胞的氧气供应。良好的氧气供应被认为是必不可少的，尤其是对于肌肉和神经细胞。人们通常会通过运动、良好的营养或药物来改善人体内的氧气供应。然而，通常情况下，每个个体的氧气供应仍然可以得到改善，如有必要，可以借助营养补充剂。
氧化应激，即体内活性氧物质的形成，被认为是潜在的致病因素，并且人们认为需要减少氧化应激。一氧化氮(NO)作为自由基清除剂，可以清除活性氧，并且可以作为信号发送器。稍微增加内源性一氧化氮浓度被认为是正确的。
因此，作为营养补充剂，希望有一种粉末组合物，其能够尽可能快速且完全溶解在水中，以提供一种健康、可口服的溶液，该溶液具有吸引人的外观和良好的口感，能够使成分具有较高的生物利用度，改善人体内的氧化作用，减少氧化应激，并略微增加内源性一氧化氮浓度。
发明内容
针对上述目标，本申请通过用于制备口服溶液(作为营养补充剂)的粉末组合物至少解决了部分目标，其中该组合物每100g含有1g至85g的至少一种单糖、0.18g至0.70g的至少一种甜菊糖苷、1.5g至10g柠檬酸、0.3g至3g维生素C、至少两种其他维生素和绿茶(茶树(Camellia sinensis))提取物。
可以通过仅向饮用容器中的粉末组合物添加水并在室温(约20℃)下短暂搅拌来制备溶液。悬浮液也是一种解决方案并且包括在本申请中，只要悬浮部分基本上可与溶液一起饮用并且不留在饮用容器的底部。在本申请的含义内，其中主要成分沉淀到饮用容器底部的组合物不认为是一种解决方案。
本申请的优点是溶液中的成分可以特别快速地进入血液。
至少一种单糖可使粉末在水中迅速溶解并具有良好的口感。至少一种甜菊糖苷也有助于改善口感。通过组合至少一种单糖和至少一种甜菊糖苷，可获得一种特别健康的产品，因为可以减少单糖的量并且溶液仍含有至少一种单糖作为能量载体。柠檬酸也有助于特殊的味觉体验。该组合物不需要人工甜味剂，且优选地，该组合物不含人工甜味剂。
出人意料的是，该组合物具有微生物稳定性。该组合物不需要人工防腐剂，且优选地，该组合物不含人工防腐剂。
维生素C和至少两种其他维生素都不属于绿茶提取物。优选地，维生素C和至少两种其他维生素作为纯物质添加。
动词“含有”/“包括”(contain/comprise)及其词形变化也包括动词“含有”(consist of)及其词形变化。
只要上下文没有另外指出，本申请的优选实施例可以相互组合。
优选实施例也在权利要求中给出。
在优选实施例中，该组合物每100g含有5g至80g的至少一种单糖、0.19g至0.60g的至少一种甜菊糖苷、2.5g至7.0g柠檬酸和0.4g至2.5g维生素C。
优选地，该组合物每100g含有4.14mg至3000mg绿茶(茶树(Camellia sinensis))提取物，优选绿茶叶提取物。该提取物含有有价值的多酚、儿茶素，并且有助于形成溶液的特殊口味。
优选地，该组合物含有：
西兰花(Brassica oleracea italica)浓缩物，特别是西兰花的种子、芽和/或嫩枝的浓缩物，和/或
西兰花(Brassica oleracea italica)浓缩物，特别是西兰花的小花和/或茎的浓缩物，和/或
洋葱(Allium cepa，特别是Allium cepa alliaceae)提取物，特别是洋葱鳞茎的提取物，和/或
苹果(Malus domestica)提取物，特别是苹果果实、更具体地是苹果果皮的提取物，和/或
针叶樱桃(Malpighia glabra，特别是Malpighia glabra linne)提取物，特别是针叶樱桃果实的提取物，和/或
番茄(Lycopersicon esculentum)浓缩物，特别是番茄果实的浓缩物，和/或
姜黄(Curcuma longa)浓缩物，特别是姜黄根的浓缩物，和/或
大蒜(Allium sativum)浓缩物，特别是蒜瓣的浓缩物，和/或
罗勒(Ocimum basilicum)浓缩物，特别是罗勒叶的浓缩物，和/或
牛至(Origanum vulgare)浓缩物，特别是牛至叶的浓缩物，和/或
肉桂树(Cinnamonum cassia)浓缩物，特别是肉桂树的树皮(不含软木)的浓缩物，和/或
胡萝卜(Dacus carota，特别是Dacus carota sativa)浓缩物，特别是胡萝卜根部的浓缩物，和/或
接骨木(Sambucus nigra)浓缩物，特别是接骨木果实的浓缩物，和/或
醋栗(Ribes)提取物，特别是黑醋栗(Ribes nigrum)，更具体地是黑醋栗果实的提取物，和/或
蓝莓(Vaccinium)浓缩物，特别是蓝莓的果实的浓缩物，和/或
覆盆子(Rubus idaeus)浓缩物，特别是覆盆子果实的浓缩物，和/或
黑莓(Rubus spp.)浓缩物，特别是黑莓果实的浓缩物，和/或
花楸果(Aronia，特别是Aronia melanocarpa)浓缩物，特别是花楸果果实的浓缩物，和/或
菠菜(Spinacia oleracea)浓缩物，特别是菠菜叶子的浓缩物，和/或
樱桃(Prunus avium)浓缩物，特别是樱桃果实的浓缩物，和/或
球芽甘蓝(Brassica oleracea gemmifera)浓缩物，特别是球芽甘蓝的小花的浓缩物。
优选地，该组合物每100g含有0.10g至0.75g的上述提取物和/或浓缩物。
优选地，该组合物包含：
西兰花(Brassica oleracea italica)浓缩物，特别是西兰花的种子、芽和/或嫩枝的浓缩物，和
西兰花(Brassica oleracea italica)浓缩物，特别是西兰花的小花和/或茎的浓缩物，和
洋葱(Allium cepa，特别是Allium cepa alliaceae)提取物，特别是洋葱的鳞茎的提取物，和
苹果(Malus domestica)提取物，特别是苹果果实、更具体地是苹果果皮的提取物，和
针叶樱桃(Malpighia glabra，特别是Malpighia glabra linne)提取物，特别是针叶樱桃果实的提取物，和
番茄(Lycopersicon esculentum)浓缩物，尤其是番茄果实的浓缩物，和
姜黄(Curcuma longa)浓缩物，特别是姜黄根的浓缩物，和
大蒜(Allium sativum)浓缩物，特别是蒜瓣的浓缩物，以及
罗勒(Ocimum basilicum)浓缩物，特别是罗勒叶的浓缩物，和
牛至(Origanum vulgare)浓缩物，特别是牛至叶子的浓缩物，和
肉桂树(Cinnamonum cassia)浓缩物，特别是肉桂树的树皮(没有软木)的浓缩物，和
胡萝卜(Dacus carota，尤其是Dacus carota sativa)浓缩物，尤其是胡萝卜根部的浓缩物，和
接骨木(Sambucus nigra)浓缩物，特别是接骨木果实的浓缩物，和
醋栗(Ribes)提取物，特别是黑醋栗(Ribes nigrum)、更具体地是黑醋栗果实的提取物，和
蓝莓(Vaccinium)浓缩物，特别是蓝莓果实的浓缩物，和
覆盆子(Rubus idaeus)浓缩物，特别是覆盆子果实的浓缩物，和
黑莓(Rubus spp.)浓缩物，特别是黑莓果实的浓缩物，和
花楸果(Aronia，特别是Aronia melanocarpa)浓缩物，特别是花楸果果实的浓缩物，和
菠菜(Spinacia oleracea)浓缩物，特别是菠菜叶子的浓缩物，和
樱桃(Prunus avium)浓缩物，特别是樱桃果实的浓缩物，和
球芽甘蓝(Brassica oleracea gemmifera)浓缩物，尤其是球芽甘蓝的小花的浓缩物。
优选地，该组合物每100g含有0.10g至0.75g的上述提取物和浓缩物。
术语“提取物”是指植物相应部位的干缩提取物，其中提取物优选通过有机溶剂和/或水的方式获得，并使用在120:1和10:1之间的药物-提取物比。“浓缩物”是指来自植物相应部位的脱水产物。根据植物种类，从果实、叶子、鳞茎、树皮(不包括软木)、根、根茎、块茎、种子、芽、嫩枝、小花和茎获得的提取物和浓缩物可提供高水平的有价值的植物次生代谢物，如多酚。多酚是含有两个或多个直接连接到芳环上的羟基的芳香化合物，并被归类为植物次生代谢物。多酚具有多种健康促进作用；特别是一些多酚具有抗氧化作用。多种植物的浓缩物和提取物提供多种促进健康的植物次生代谢物、维生素和多酚。这种组合物可以增加组合物中所含化合物的生物利用度。因此，可得到一种具有特别的健康促进作用并且特别支持均衡饮食的组合物。此外，发明人发现，本申请中提到的提取物和/或浓缩物的添加对粉末在水中的溶解和溶液的味道具有积极的影响。
优选地，该组合物在各种情况下每100g含有4mg至200mg、优选5mg至50mg的一种或多种选自胡椒(Piper nigrum)提取物和姜(Zingiber officinale)提取物的成分。优选地，该组合物每100g含有4mg至200mg(优选5mg至50mg)辣椒(Piper nigrum)提取物、0.25mg至2g(优选0.45mg至1.5g)姜黄素化合物，和4mg至200mg(优选5mg至50mg)生姜(Zingiberofficinale)提取物。姜黄素化合物可以是姜黄素-环糊精复合物，特别是姜黄素-γ-环糊精复合物。优选地，生姜提取物是生姜(Zingiber officinale)根茎的提取物。这些物质，即使是如此小的剂量，也可发挥生物增强剂的作用，并增加组合物成分的生物利用度。
优选地，该组合物每100g含有2.3mg至5g、更优选4.14mg至3g咖啡(Coffeaarabica)提取物，优选咖啡豆提取物。
优选地，该组合物每100g含有0.025mg至2g、更优选0.045mg至1.5g酸樱桃(Prunuscerasus)提取物，优选酸樱桃果实的提取物。
优选地，该组合物每100g含有0.025mg至2g、更优选0.045mg至1.5g卷心菜(Brassica oleracea acephala)提取物，优选卷心菜叶子的提取物。
优选地，该组合物每100g含有0.25mg至2g、更优选0.45mg至1.5g姜黄(Curcumalonga)提取物，优选姜黄根的提取物。
优选地，该组合物每100g含有0.025mg至2g、更优选0.045mg至1.5g西兰花(Brassica oleracea italica)提取物，优选西兰花小花的提取物。
优选地，该组合物每100g含有0.025mg至2g、更优选0.045mg至1.5g蓝莓(Vaccinium corymbosum)提取物，优选蓝莓果实提取物。
优选地，该组合物含有咖啡(Coffea arabica)(优选咖啡豆)的提取物，酸樱桃(Prunus cerasus)(优选酸樱桃果实)的提取物，卷心菜(Brassica oleracea acephala)(优选卷心菜叶子)的提取物，姜黄(Curcuma longa)(优选姜黄根)的提取物，西兰花(Brassica oleracea italica)(优选西兰花的小花)的提取物，蓝莓(Vacciniumcorymbosum)(优选蓝莓果实)的提取物，以及绿茶(Camellia sinensis)(优选绿茶叶)的提取物。其中该组合物每100g含有0.01g至5g的上述提取物。这些提取物，尤其在结合使用的情况下，可以增加内源性一氧化氮的浓度。
优选地，该组合物每100g含有100mg至1000mg咖啡因。咖啡因可以是瓜拉那提取物。
具体实施方式
在本申请的一个实施例中，所述至少两种其他维生素选自B族维生素(B族维生素实施例)。优选地，该实施例中的组合物每100g含有1g至85g，更优选5g至80g的至少一种单糖。优选地，该实施例中的组合物每100g含有0.19g至0.60g的至少一种甜菊糖苷。优选地，该实施例中的组合物每100g含有2.5g至7.0g柠檬酸。优选地，该实施例中的组合物每100g还含有50mg至200mg藻粉和任选地3g至12g、更优选4g至10g的瓜拉那提取物。此外，瓜拉那提取物可能会产生咖啡因。优选地，藻粉为褐藻粉。优选地，在该实施例中，上述组合物含有葡萄糖作为至少一种单糖。在该实施例中，优选地，该组合物每100g含有100mg至1500mg烟酸、20mg至270mg泛酸、5mg至100mg吡哆醇、4mg至72mg核黄素、5mg至70mg硫胺素、10μg至10mg氰钴胺、0.5mg至7mg生物素和0.5mg至12mg叶酸。葡萄糖在水中溶解得非常快，并与其他成分结合，使溶液具有特殊的味道。此外，葡萄糖可以改善某些成分的吸收。特别地，该实施例有助于改善组织的氧气供应。
在本申请的替代实施例中，至少两种其他维生素选自维生素A和E(维生素A和E实施例)。优选地，该实施例中的组合物每100g含有1500μg至4000μg视黄醇当量和60mg至120mgα-生育酚当量。优选地，该实施例中的组合物每100g含有5g至80g、更优选5g至70g、最优选5g至42g的至少一种单糖。优选地，该实施例中的组合物每100g含有0.19g至0.60g的至少一种甜菊糖苷。优选地，该实施例中的组合物每100g含有2.0g至7.0g柠檬酸。优选地，该实施例中的组合物含有果糖作为至少一种单糖。优选地，该实施例中的组合物每100g含有200μg至350μg硒。优选地，该实施例中的组合物每100g含有35g至85g膳食纤维。优选地，膳食纤维来自燕麦、豌豆、大米和/或苹果的植物纤维。果糖在水中很快溶解，并与其他成分结合，使溶液味道可口。令人惊讶的是，尽管纤维含量很高，但这种特殊的组合物仍可用于生成溶液。该实施例对肠道健康特别有益，并可以激活免疫***。在这种变体中，组合物的成分可以被更好地吸收。在该替代实施例中，还优选该组合物含有消化酶(淀粉酶、蛋白酶、乳糖酶、纤维素酶和脂肪酶)和姜黄素-γ-环糊精复合物。在该替代实施例中，还优选组合物含有革兰氏阳性非孢子形成细菌，例如(嗜酸乳杆菌、罗伊氏乳杆菌)和/或革兰氏阳性芽孢细菌，例如芽孢杆菌。
该组合物还可包含赋形剂，例如甜菜粉(甜菜汁浓缩物、麦芽糊精)、***树胶、果胶和/或瓜尔豆胶。
本申请还涉及根据本申请用于制备口服溶液的组合物的用途。或者换句话说，制备口服溶液的方法。本文中，将粉末组合物溶解在水中以制备溶液。
在这点上，在B族维生素实施例中，在室温下将1.25g至2.25g的组合物加入到约40mL的水中并混合以获得溶液。优选地，该产品每天食用三次。
在维生素A和E的实施例中，在室温下将8g至16g的组合物加入到大约180mL的水中并混合以获得溶液。优选地，该产品每天食用一次。
下面通过两个示例解释本申请。
B族维生素实施例的示例配方
100克本示例的粉末组合物含有：
2.5g维生素C；
0.34g烟酸；
0.8g咖啡因；
0.05g泛酸；
0.02g吡哆醇；
0.02g硫胺素；
0.02mg核黄素；
10μg氰钴胺；
2.0mg叶酸；
1.5mg生物素；
7.5g柠檬酸；
9.5g瓜拉那提取物；
0.4g甜菊糖苷；
0.1g藻粉；
5mg绿茶提取物(Camellia sinensis)；
1g甜菜粉(浓缩甜菜汁、麦芽糊精)；
100g无水葡萄糖。
维生素A和E实施例的示例配方
100克本示例的粉末组合物含有：
0.3g甜菊糖苷；
3.5g柠檬酸；
1.5g维生素C；
0.08g绿茶提取物(Camellia sinensis)；
2000μg视黄醇当量；
70mgα-生育酚当量；
250μg硒；
46g膳食纤维；
0.3g嗜酸乳杆菌、罗伊氏乳杆菌；
0.3g淀粉酶、蛋白酶、乳糖酶、纤维素酶和脂肪酶；
100g果糖。
粉末组合物在水中迅速溶解，形成健康、可饮用的溶液，不含人工防腐剂或甜味剂。该溶液外观美观，口感好，成分的生物利用度高，可改善人体所需的氧气、必需的维生素、多酚等物质的供应。

Claims (15)

1.一种用于制备口服溶液的粉末组合物，其特征在于，
所述组合物每100g含有：
1g至85g的至少一种单糖，
0.18g至0.70g的至少一种甜菊糖苷，
1.5g至10g柠檬酸，
0.3g至3g维生素C，
至少两种其他维生素，和
绿茶(Camellia sinensis)提取物。
2.根据权利要求1所述的组合物，其特征在于，所述组合物含有：西兰花(Brassicaoleracea italica)浓缩物、
洋葱(Allium cepa)提取物、
苹果(Malus domestica)提取物、
针叶樱桃(Malpighia glabra)提取物、
番茄(Lycopersicon esculentum)浓缩物、
姜黄(Curcuma longa)浓缩物、
大蒜(Allium sativum)浓缩物、
罗勒(Ocimum basilicum)浓缩物、
牛至(Origanum vulgare)浓缩物、
肉桂树(Cinnamonum cassia)浓缩物、
胡萝卜(Dacus carota)浓缩物、
接骨木(Sambucus nigra)浓缩物、
醋栗(Ribes)提取物、
蓝莓(Vaccinium)浓缩物、
覆盆子(Rubus idaeus)浓缩物、
黑莓(Rubus spp.)浓缩物、
野樱莓(Aronia)浓缩物、
菠菜(Spinacia oleracea)浓缩物、
樱桃(Prunus avium)浓缩物、
蓝莓(Vaccinium)提取物，和
球芽甘蓝(Brassica oleracea gemmifera)浓缩物。
3.根据前述权利要求任一项所述的组合物，其特征在于，所述组合物每100g含有2.3mg至5g咖啡(Coffea arabica)提取物。
4.根据前述权利要求任一项所述的组合物，其特征在于，所述组合物每100g含有4mg至200mg辣椒(Piper nigrum)提取物、0.25mg至2g姜黄素化合物和4mg至200mg生姜(Zingiberofficinale)提取物。
5.根据前述权利要求任一项所述的组合物，其特征在于，所述组合物含有咖啡(Coffeaarabica)提取物、酸樱桃(Prunus cerasus)提取物、卷心菜(Brassica oleraceaacephala)提取物、姜黄(Curcuma longa)提取物、西兰花(Brassica oleracea italica)提取物，和蓝莓(Vaccinium corymbosum)提取物。
6.根据前述权利要求任一项所述的组合物，其特征在于，所述至少两种其他维生素选自B族维生素，并且所述组合物每100g含有50mg至200mg藻粉，以及任选地3g至12g瓜拉那提取物。
7.根据权利要求6所述的组合物，其特征在于，所述至少一种单糖是葡萄糖。
8.根据权利要求6或7所述的组合物，其特征在于，所述组合物每100g含有作为B族维生素的：
100mg至1500mg烟酸，
20mg至270mg泛酸，
5mg至100mg吡哆醇，
4mg至72mg核黄素，
5mg至70mg硫胺素，
10μg至10mg氰钴胺，
0.5mg至7mg生物素，和
0.5mg至10mg叶酸。
9.根据前述权利要求任一项所述的组合物，其特征在于，所述组合物每100g含有100mg至1000mg咖啡因。
10.根据前述权利要求1至5任一项所述的组合物，其中特征在于，所述至少两种其他维生素选自维生素A和E，并且所述组合物每100g含有1500μg至4000μg视黄醇当量和60mg至120mgα-生育酚当量。
11.根据权利要求10所述的组合物，其特征在于，所述至少一种单糖是果糖。
12.根据权利要求10或11所述的组合物，其特征在于，所述组合物每100g含有200μg至350μg硒。
13.根据权利要求10至12任一项所述的组合物，其特征在于，所述组合物每100g含有35g至85g膳食纤维。
14.根据权利要求10至13任一项所述的组合物，其特征在于，所述组合物包括：
i)淀粉酶、蛋白酶、乳糖酶、纤维素酶和脂肪酶，
ii)姜黄素-γ-环糊精复合物；和
任选地iii)革兰氏阳性非孢子形成细菌，例如嗜酸乳杆菌、罗伊氏乳杆菌，和/或革兰氏阳性芽孢细菌，例如芽孢杆菌属。
15.根据权利要求1至14任一项所述的组合物在制备口服溶液中的用途。
CN202180020598.9A 2020-03-11 2021-01-14 用于制备可饮用产品的粉末组合物 Pending CN115243553A (zh)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009053802A1 (de) * 2007-10-24 2009-04-30 Karl Zehethofer Functional drink
US20100209585A1 (en) * 2007-08-30 2010-08-19 Kao Corporation Instant powder drink
WO2017220220A1 (de) * 2016-06-23 2017-12-28 Frank Holtey Nahrungsergänzungsmittel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413558B1 (en) * 1999-07-19 2002-07-02 The Proctor & Gamble Co. Compositions, kits, and methods for providing and maintaining energy and metal alertness
CN101562987B (zh) * 2006-12-22 2013-06-12 花王株式会社 容器装绿茶饮料

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100209585A1 (en) * 2007-08-30 2010-08-19 Kao Corporation Instant powder drink
WO2009053802A1 (de) * 2007-10-24 2009-04-30 Karl Zehethofer Functional drink
WO2017220220A1 (de) * 2016-06-23 2017-12-28 Frank Holtey Nahrungsergänzungsmittel
CN107846954A (zh) * 2016-06-23 2018-03-27 弗兰克·霍尔特利 营养补充药物

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