CN115228293A - Modular ultrafiltration system - Google Patents
Modular ultrafiltration system Download PDFInfo
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- CN115228293A CN115228293A CN202210725170.0A CN202210725170A CN115228293A CN 115228293 A CN115228293 A CN 115228293A CN 202210725170 A CN202210725170 A CN 202210725170A CN 115228293 A CN115228293 A CN 115228293A
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- pipeline
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- ultrafiltration
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- pressure sensor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/18—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/20—Accessories; Auxiliary operations
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- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
The invention provides a modular ultrafiltration system, relates to the technical field of biological pharmacy, and aims to solve the problem that cross contamination is easily caused due to inconvenient pipeline cleaning in the use process of an ultrafiltration assembly in the prior art. This modularization ultrafiltration system includes ultrafiltration apparatus and ultrafiltration module, ultrafiltration module detachable installs on ultrafiltration apparatus, ultrafiltration module includes the feed liquid bag, the sample inlet pipeline, filter module, filter out pipeline and return line, the entry section and the feed liquid bag of sample inlet pipeline are linked together, the last three port that is provided with of filter module at least, be first port respectively, second port and third port, the export of sample inlet pipeline is connected with filter module's first port, the second port is connected with return line, the tip of keeping away from the second port on the return line is linked together with the feed liquid bag, the third port is connected with the filter out pipeline, the sample inlet pipeline, it all is provided with pressure measurement on pipeline and the return line to filter out.
Description
Technical Field
The invention relates to the technical field of biological pharmacy, in particular to a modular ultrafiltration system.
Background
Ultrafiltration is a membrane separation technique that can purify and separate solutions, one of which is a membrane separation technique that uses pressure as a driving force and aims to separate macromolecules from small molecules.
The existing ultrafiltration system mainly comprises ultrafiltration equipment and an ultrafiltration component, wherein the ultrafiltration component and the ultrafiltration equipment are fixed together, and the ultrafiltration component is a group of pipeline structures formed by taking an ultrafiltration membrane as a core.
The ultrafiltration membrane is a solution separation device which takes ultrafiltration membrane filaments as a filter medium and takes the pressure difference between two sides of the membrane as a driving force. The ultrafiltration membrane only allows the solvent (such as water molecules), inorganic salt and small molecular organic matters in the solution to permeate, and retains suspended substances, colloids, proteins, microorganisms and other macromolecular substances in the solution, thereby achieving the purpose of purification or separation.
However, the applicant has found that the prior art has at least the following technical problems:
the common ultrafiltration module often has the problem of inconvenient pipeline cleaning in the use process. In the use of the conventional ultrafiltration module, the longer the usage time is, the more garbage is accumulated in the conventional ultrafiltration module, a large amount of human resources are wasted in cleaning, and cross contamination is easily caused.
Disclosure of Invention
In view of this, the present invention provides a modular ultrafiltration system, so as to solve the technical problem that the pipeline is inconvenient to clean and cross contamination is easily caused in the process of using the ultrafiltration module in the prior art.
In order to achieve the above object, the present invention provides a modular ultrafiltration system comprising an ultrafiltration unit and an ultrafiltration module detachably mounted on the ultrafiltration unit, wherein: the ultrafiltration component comprises a feed liquid bag, a sample introduction pipeline, a filter module, a filtering pipeline and a return pipeline, wherein an inlet section of the sample introduction pipeline is communicated with the feed liquid bag, the filter module is at least provided with three ports, namely a first port, a second port and a third port, an outlet of the sample introduction pipeline is connected with the first port of the filter module, the second port is connected with the return pipeline, the return pipeline is kept away from the end part of the second port and the feed liquid bag, the third port is connected with the filtering pipeline, the sample introduction pipeline is filtered and the return pipeline is provided with a pressure detection device.
As a further improvement of the present invention, the pressure detection device includes a sample introduction end pressure sensor, a filtering out end pressure sensor and a return end pressure sensor, the sample introduction pipe is provided with the sample introduction end pressure sensor, the filtering out pipe is provided with the filtering out end pressure sensor, and the return pipe is provided with the return end pressure sensor.
As a further improvement of the invention, a power pump structure is arranged on the sample inlet pipeline and is arranged between the feed liquid bag and the sample inlet end pressure sensor.
As a further improvement of the invention, a temperature sensor and a conductivity sensor are further arranged on the filtration pipeline, and a container for containing the permeate liquid is connected to the end part of the filtration pipeline far away from the third port.
As a further improvement of the present invention, the filtration module comprises a hollow fiber membrane, the hollow fiber membrane is detachably mounted on the ultrafiltration apparatus, the lower part of the hollow fiber membrane is provided with the first port, the upper part of the hollow fiber membrane is provided with the second port, and the side part of the hollow fiber membrane is provided with the third port.
As a further improvement of the invention, the sample introduction pipeline, the filtering pipeline and the return pipeline are all plastic hoses or rubber hoses, and the material of the sample introduction pipeline, the material of the filtering pipeline and the material of the return pipeline are the same.
As a further improvement of the present invention, the ultrafiltration apparatus includes a housing, a display screen, and a control module disposed inside the housing, wherein the display screen is disposed on the housing, the housing is provided with a mounting seat for mounting the hollow fiber membrane, the housing is provided with a sensor interface, the sample inlet pressure sensor, the filter outlet pressure sensor, the return outlet pressure sensor, the temperature sensor, and the conductivity sensor are connected to the control module through the corresponding sensor interfaces, and the control module is connected to the display screen.
As a further improvement of the present invention, a back pressure valve and a pipeline fixing clamp seat are fixedly arranged on the outer surface of the housing, the sample introduction pipeline and the filtering pipeline are both installed on the pipeline fixing clamp seat at corresponding positions, and the return pipeline is installed on the back pressure valve.
The modular ultrafiltration system provided by the invention comprises ultrafiltration equipment and an ultrafiltration component, wherein the ultrafiltration component is detachably arranged on the ultrafiltration equipment, the ultrafiltration component has the advantage of pressure measurement, and meanwhile, a pressure detection device, a feed liquid bag, a sample introduction pipeline, a filtering pipeline and a return pipeline of the ultrafiltration component are replaceable, so that the convenience in use is improved, the cost is saved, the cross contamination and the bacterial contamination are avoided, and meanwhile, the cleaning and verification procedure is saved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic diagram of the structure of an ultrafiltration module provided in an embodiment of the present invention;
fig. 2 is a schematic diagram of a modular ultrafiltration system provided by an embodiment of the present invention.
Reference numerals: 1. a feed liquid bag; 2. a sample introduction pipeline; 3. filtering out the pipeline; 4. a return line; 5. a sample introduction end pressure sensor; 6. filtering out an end pressure sensor; 7. a return end pressure sensor; 8. a temperature sensor; 9. a conductivity sensor; 10. a hollow fiber membrane.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
In the description of the present invention, it is to be noted that, unless otherwise specified, "a plurality" means two or more; the terms "upper", "lower", "left", "right", "inner", "outer", "front", "rear", "head", "tail", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are only for convenience in describing and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, should not be construed as limiting the invention. Furthermore, the terms "first," "second," "third," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; may be directly connected or indirectly connected through an intermediate. The specific meaning of the above terms in the present invention can be understood as appropriate to those of ordinary skill in the art.
Referring to fig. 1 and 2, the present invention provides a modular ultrafiltration system, comprising an ultrafiltration apparatus and an ultrafiltration module, wherein the ultrafiltration module is detachably mounted on the ultrafiltration apparatus, so as to facilitate replacement of the ultrafiltration module.
In this embodiment, the ultrafiltration assembly includes a feed liquid bag 1, a sample introduction pipeline 2, a filter module, a filtering pipeline 3 and a return pipeline 4, an inlet section of the sample introduction pipeline 2 is communicated with the feed liquid bag 1, the filter module is at least provided with three ports, which are a first port, a second port and a third port, respectively, an outlet of the sample introduction pipeline 2 is connected with the first port of the filter module, the second port is connected with the return pipeline 4, an end portion of the return pipeline 4 far away from the second port is communicated with the feed liquid bag 1, the third port is connected with the filtering pipeline 3, and pressure detection devices are arranged on the sample introduction pipeline 2, the filtering pipeline 3 and the return pipeline 4.
Specifically, the pressure detection device in this embodiment includes a sample injection end pressure sensor 5, a filtering end pressure sensor 6, and a return end pressure sensor 7, the sample injection end pressure sensor 5 is provided on the sample injection pipeline 2, the filtering end pressure sensor 6 is provided on the filtering pipeline 3, and the return end pressure sensor 7 is provided on the return pipeline 4.
In addition, a power pump structure is arranged on the sample injection pipeline 2, and the power pump structure in the embodiment is arranged between the feed liquid bag 1 and the sample injection end pressure sensor 5, so that the liquid in the feed liquid bag 1 can be conveniently pumped into the filter module.
The filtering pipeline 3 in this embodiment is further provided with a temperature sensor 8 and a conductivity sensor 9, and the end of the filtering pipeline 3 far away from the third port is connected with a container for containing the permeation liquid.
The ultrafiltration device comprises a shell, a display screen and a control module arranged in the shell, wherein the display screen is arranged on the shell, a mounting seat used for mounting the hollow fiber membrane 10 is arranged on the shell, a sensor interface is arranged on the shell, the sample inlet end pressure sensor 5, the filter outlet end pressure sensor 6, the return end pressure sensor 7, the temperature sensor 8 and the conductivity sensor 9 are connected with the control module through corresponding sensor interfaces, and the control module is connected with the display screen.
In the ultrafiltration assembly provided by the invention, the pressure sensor, the temperature sensor 8 and the conductivity sensor 9 are connected with corresponding pipelines, so that the measurement of pressure, temperature and conductivity data of ultrafiltration equipment can be realized, the data of the pressure sensor, the temperature sensor 8 and the conductivity sensor 9 are timely fed back to the ultrafiltration equipment, an operator can observe and record related pressure, temperature and conductivity values in real time, and different pressure sensors, temperature sensors 8 and conductivity sensors 9 can be conveniently and easily replaced to measure pressure, temperature and conductivity data with different sizes, and the complicated step of disassembling boxes and replacing various sensors is avoided.
The filtration module in this embodiment may be a hollow fiber membrane 10, and of course, the filtration module in this embodiment may also be a plate-type membrane, which is not specifically limited herein. When the filtration module in this embodiment is the hollow fiber membrane 10, the hollow fiber membrane 10 is detachably mounted on the ultrafiltration apparatus, the lower portion of the hollow fiber membrane 10 is provided with a first port, the upper portion of the hollow fiber membrane 10 is provided with a second port, and the side portion of the hollow fiber membrane 10 is provided with a third port.
As an optional implementation manner of this embodiment, the sample inlet pipeline 2, the filtering out pipeline 3, and the return pipeline 4 are all plastic hoses or rubber hoses, and the sample inlet pipeline 2, the filtering out pipeline 3, and the return pipeline 4 are made of the same material. In order to avoid cross contamination and contamination, the feed liquid bag 1, the sample introduction pipeline 2, the filtering out pipeline 3 and the return pipeline 4 are preferably made of disposable materials, so that cleaning verification is omitted, and the time of CIP (clean in place) and SIP (sterilize in place) is saved. Different feed liquid bags 1, sample introduction pipelines 2, filtering pipelines 3 and return pipelines 4 can be replaced, and different feed liquids can be ultrafiltered.
In addition, the external fixed surface of casing is provided with back pressure valve and the fixed cassette of pipeline, advances appearance pipeline 2 and filters out pipeline 3 and all installs on the fixed cassette of pipeline that corresponds position department, realizes advancing appearance pipeline 2 and filtering out the fixed of pipeline 3 through fixed cassette, and return line 4 installs on the back pressure valve for can be used for fixed return line 4 when adjusting the fluid pressure in return line 4. It should be noted that the back pressure valve and the pipe fixing seat in the embodiment are structures in the prior art, and are not described in detail herein.
During specific implementation, an operator can directly connect the feed liquid bag 1, the pressure detection device (the sampling end pressure sensor 5, the filtering end pressure sensor 6 and the return end pressure sensor 7), the temperature sensor 8 and the conductivity sensor 9 with the sampling pipeline 2, the filtering pipeline 3 and the return pipeline 4 and then respectively connect the pressure detection device, the temperature sensor 8 and the conductivity sensor 9 with corresponding sensor interfaces on the ultrafiltration device.
When ultrafiltration equipment during operation, pressure detection device can measure the sample inlet pipeline 2 that corresponds, filter out the pressure value in pipeline 3, the return line 4 and real-timely through the display screen record show, has avoided the loaded down with trivial details operation of experiment, has increased the convenience of experiment simultaneously. The temperature sensor 8 and the conductance sensor 9 can measure the temperature value and the conductance value in the filtering pipeline 3 and record and display the temperature value and the conductance value in real time. The method does not need to measure related numerical values independently, reduces the steps of the experiment and brings convenience to the experiment work. The sample introduction end pressure sensor 5, the filtering end pressure sensor 6, the backflow end pressure sensor 7, the temperature sensor 8 and the conductivity sensor 9 are only required to be directly replaced from the outside of the ultrafiltration equipment, so that the operation is simpler and more convenient, and the labor cost is also reduced.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (8)
1. A modular ultrafiltration system, comprising an ultrafiltration unit and an ultrafiltration module removably mounted on the ultrafiltration unit, wherein:
the ultrafiltration component comprises a feed liquid bag, a sample introduction pipeline, a filter module, a filtering pipeline and a return pipeline, wherein an inlet section of the sample introduction pipeline is communicated with the feed liquid bag, the filter module is at least provided with three ports, namely a first port, a second port and a third port, an outlet of the sample introduction pipeline is connected with the first port of the filter module, the second port is connected with the return pipeline, the return pipeline is kept away from the end part of the second port and the feed liquid bag, the third port is connected with the filtering pipeline, the sample introduction pipeline is filtered and the return pipeline is provided with a pressure detection device.
2. The modular ultrafiltration system of claim 1, wherein the pressure detection device comprises a sample inlet end pressure sensor, a filtrate outlet end pressure sensor, and a return end pressure sensor, the sample inlet line having the sample inlet end pressure sensor disposed thereon, the filtrate outlet line having the filtrate outlet end pressure sensor disposed thereon, the return line having the return end pressure sensor disposed thereon.
3. The modular ultrafiltration system of claim 2, wherein the sample inlet conduit is configured with a power pump structure disposed between the fluid bag and the sample inlet end pressure sensor.
4. The modular ultrafiltration system of claim 2, wherein the filtrate line further comprises a temperature sensor and a conductivity sensor, and a vessel for holding permeate is connected to an end of the filtrate line distal to the third port.
5. The modular ultrafiltration system of claim 4, wherein the filtration module comprises hollow fiber membranes detachably mounted on the ultrafiltration device, wherein the first port is provided at a lower portion of the hollow fiber membranes, the second port is provided at an upper portion of the hollow fiber membranes, and the third port is provided at a side portion of the hollow fiber membranes.
6. The modular ultrafiltration system of claim 1, wherein the sample inlet line, the filtrate line, and the return line are plastic or rubber hoses, and wherein the sample inlet line, the filtrate line, and the return line are made of the same material.
7. The modular ultrafiltration system of claim 5, wherein the ultrafiltration apparatus comprises a housing, a display screen, and a control module disposed inside the housing, wherein the display screen is disposed on the housing, a mounting seat for mounting the hollow fiber membrane is disposed on the housing, a sensor interface is disposed on the housing, the sample inlet pressure sensor, the filter outlet pressure sensor, the return outlet pressure sensor, the temperature sensor, and the conductivity sensor are connected to the control module through corresponding sensor interfaces, and the control module is connected to the display screen.
8. The modular ultrafiltration system of claim 7, wherein the outer surface of the housing is fixedly provided with a back pressure valve and a pipeline fixing clamp seat, the sample inlet pipeline and the filtering pipeline are both installed on the pipeline fixing clamp seat at corresponding positions, and the return pipeline is installed on the back pressure valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210725170.0A CN115228293A (en) | 2022-06-24 | 2022-06-24 | Modular ultrafiltration system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210725170.0A CN115228293A (en) | 2022-06-24 | 2022-06-24 | Modular ultrafiltration system |
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| CN115228293A true CN115228293A (en) | 2022-10-25 |
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| CN202210725170.0A Pending CN115228293A (en) | 2022-06-24 | 2022-06-24 | Modular ultrafiltration system |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060118472A1 (en) * | 2002-06-14 | 2006-06-08 | Schick Karl G | Single-use manifold and sensors for automated, aseptic transfer of solutions in bioprocessing applications |
| US20110005984A1 (en) * | 2008-03-20 | 2011-01-13 | Sartorius Stedim Biotech Gmbh | Presterilizable filtration system to be disposed of after a single use |
| CN103298542A (en) * | 2010-10-15 | 2013-09-11 | 艾克塞勒雷克斯公司 | Large volume disposable ultrafiltration systems and methods |
| CN203648395U (en) * | 2013-12-26 | 2014-06-18 | 利穗科技(苏州)有限公司 | Automatic ultra-filtration system |
| CN207287147U (en) * | 2017-09-30 | 2018-05-01 | 上海多宁生物科技有限公司 | Disposable pipe-line system for ultrafiltration apparatus |
| US20200078740A1 (en) * | 2017-05-15 | 2020-03-12 | Sartorius Stedim Biotech Gmbh | Single-use filtering module and single-use cleaning module, each insertable in a modular filtering system |
-
2022
- 2022-06-24 CN CN202210725170.0A patent/CN115228293A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060118472A1 (en) * | 2002-06-14 | 2006-06-08 | Schick Karl G | Single-use manifold and sensors for automated, aseptic transfer of solutions in bioprocessing applications |
| US20110005984A1 (en) * | 2008-03-20 | 2011-01-13 | Sartorius Stedim Biotech Gmbh | Presterilizable filtration system to be disposed of after a single use |
| CN103298542A (en) * | 2010-10-15 | 2013-09-11 | 艾克塞勒雷克斯公司 | Large volume disposable ultrafiltration systems and methods |
| CN203648395U (en) * | 2013-12-26 | 2014-06-18 | 利穗科技(苏州)有限公司 | Automatic ultra-filtration system |
| US20200078740A1 (en) * | 2017-05-15 | 2020-03-12 | Sartorius Stedim Biotech Gmbh | Single-use filtering module and single-use cleaning module, each insertable in a modular filtering system |
| CN207287147U (en) * | 2017-09-30 | 2018-05-01 | 上海多宁生物科技有限公司 | Disposable pipe-line system for ultrafiltration apparatus |
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