CN115227958A

CN115227958A - Formula for non-permanent reversible change of skin

Info

Publication number: CN115227958A
Application number: CN202210893518.7A
Authority: CN
Inventors: 不公告发明人
Original assignee: Suzhou Nanomed Biomed Co ltd
Current assignee: Suzhou Nanomed Biomed Co ltd
Priority date: 2020-01-08
Filing date: 2020-01-08
Publication date: 2022-10-25
Also published as: CN111150930A

Abstract

The invention discloses a composition capable of reversibly changing non-permanent skin, which comprises at least one nano wafer and/or micro needle introduction instrument and at least one makeup formulation; the nano wafer and/or the micro needle introduction instrument is used for opening an introduction channel on the skin surface layer so as to facilitate the introduction of the beauty treatment formula into the skin surface layer; the skin normality is restored after a certain period of maintenance, and no problems of partial makeup or/and makeup removal occur.

Description

Formula for reversible change of non-permanent skin

The application is a divisional application of an invention patent application with the application number of 202010017884.7, which is filed on 8.1.1.2020 and is entitled "a formula with non-permanent reversible skin changes and a use method thereof".

Technical Field

The invention relates to the technical field of cosmetics, in particular to a formula for non-permanent reversible change of skin.

Background

With the development of economy and the progress of society, the requirements of life grades of people are higher and higher, and more attention is paid to make-up and skin care. For example, liquid foundation is commonly used for people, and is usually applied to the exposed parts of the skin such as the face, the back of the hand and the like to improve the color of the skin, improve the texture of the skin, whiten and hide blemishes, and resist the damage of ultraviolet rays to the skin. The current foundation liquid on the market has short makeup time, and is easy to remove makeup and make up; especially, the foundation makeup is easy to be damaged due to facial oil, sweat or water spraying in daily life; even if this is not the case, when makeup on the skin contacts the surface of other objects (e.g., human skin, clothing, paper towels, cups), a transfer of pigment occurs; therefore, the existing makeup cosmetics need to be removed every day, makeup is supplemented every day, more time is wasted for people, a plurality of cosmetics need to be used for makeup and makeup removal every time, and the skin is damaged greatly.

In order to improve makeup durability, a makeup manner of injecting a dermis appears in the makeup field, and the makeup is mainly focused on the tattooing and eyebrow tattooing fields, wherein the tattooing/eyebrow tattooing is a cosmetic surgery method which penetrates metal or plant pigment into the hypodermis by puncturing the skin and then permanently maintains the shape of the skin/eyebrow; see, for example, china CN105832632A (a highly restorative eyebrow tattooing pigment and method of using it), CN1907231A (tattooing machine), CN1575779A (device for tattooing or permanent make-up); the dermal injection is a "single needle" or "three needles", and is assisted by a power tool to vertically insert the needles into the dermis layer of the skin at an angle of 90 degrees and then permeate pigments into the dermis layer, and has the following disadvantages: 1. the skin is easy to be wounded and broken, a repair period of about one week is needed probably, water cannot be touched during the repair period, food is prohibited, otherwise infection and scabbing are caused, subcutaneous tissues can form permanent scars, even hair follicles are damaged, and the scars can also rise if the body of the scars is strong; 2. the pigment is diluted by the circulation of blood and lymph tissue fluid, the coloring stability is poor, the color complementing rate in the later period is high, the skin is repeatedly damaged by secondary color complementing, the damaged area is enlarged, scars are proliferated, the hair follicle is shrunk, and the lifelong injury is possibly caused. 3. Dermal injections are permanent make-up that cannot be replaced or modified once formed, and as the age progresses, the popular elements change. The dermal injection cosmetic method is also problematic.

In addition, the water light injection beauty treatment in the beauty skin care field is actually an injection type skin care therapy, and the required beauty injection is injected to the dermis layer tightly attached to the lower part of the epidermis by a special instrument 'water light gun' during injection; after injection, the skin can become moist and bright; but the injection is carried out by using a water light needle, and the problems of trauma and pain also exist.

Therefore, the development of a formula which is noninvasive and can stably maintain reversible non-permanent skin appearance change for a long time has great significance.

Disclosure of Invention

Aiming at the defects in the prior art, the invention provides a creative formula with reversible change of non-permanent skin, and the cosmetic formula enters and stays at a specific average depth on the surface layer of the skin through an introduction channel by virtue of a nano wafer and/or microneedle introduction technology so as to realize the cosmetic effect; in addition, because the makeup formula is positioned in the cuticle, the conditions of partial makeup removal, makeup and the like are avoided, and the effect of keeping makeup stable within a certain period of time can be achieved. In addition, with the metabolism of the skin itself, cosmetic components automatically disappear along with the stratum corneum within one day to three years according to different introduction average depths, so that the skin is restored to an untreated state; or gradually return to an untreated state as it is absorbed by the skin.

The technical purpose of the invention is realized by the following technical scheme:

a composition for reversible modification of non-permanent skin comprises at least one nano-chip and/or microneedle introducer, and at least one cosmetic formulation; the nano wafer and/or the micro needle introduction instrument is used for introducing the cosmetic formula into a skin superficial layer.

Preferably, the cosmetic formulation is introduced into the superficial layer of the skin to an average depth of 0 to 1500 microns.

Preferably, the cosmetic formulation is introduced into the superficial skin layer to an average depth of 1 to 500 microns.

Preferably, the makeup formula is one or more of a tattoo dye solution, a eyebrow tattoo dye solution, lip gloss, eye shadow, facial foundation, facial makeup, hyaluronic acid, cross-linked hyaluronic acid, collagen or human-like collagen. The tattoo dye solution is a general name of dyes and medicaments for tattoo; the lip gloss is a general name of cosmetics for lip beautification; the eye shadow is a general name of color cosmetics and is used for being coated on the eyelid (namely eyelid) and the canthus to generate shadow and tone contrast; the foundation is a general name of cosmetics applied to the whole face to perform the functions of decoration and covering; the facial makeup is a general name of beauty cosmetics which endow facial skin with color by using color change and trim facial skin color; hyaluronic acid, namely hyaluronic acid, has the functions of protecting and moisturizing and is a main component of skin moisturizing skincare products; the cross-linked hyaluronic acid is formed by mutually connecting hyaluronic acid molecules by a cross-linking method and then enhancing the binding force and strength; the collagen and the human-like collagen are used for moistening skin, moisturizing, removing wrinkles and beautifying.

Preferably, the facial makeup is a skin-brightening and youthful-keeping powder base solution; the rejuvenating, skin-brightening and youthful-look-retaining liquid foundation comprises the following components in percentage by mass: 1-8% of a sun-screening component, 2-10% of a whitening component, 1-10% of a whitening and skin-nourishing component, 110-20% of a humectant I, 1-10% of a humectant II, 0.2-1% of a thickening agent, 0.4-1.6% of a preservative and the balance of water.

Preferably, the sunscreen component is one or more of titanium dioxide I, zinc oxide, cerium oxide, hydroxy pinacolone retinoic acid ester, lotus flower extract for enhancing mitochondrion autophagy and vascular endothelial growth factor; the whitening component is titanium dioxide II, the whitening and skin-nourishing component is pearl powder, the humectant I is glycerol, and the humectant II is sodium hyaluronate.

Preferably, the sunscreen component is: preferably, the titanium dioxide I is rutile type, and the particle size range is 1-1000nm; the titanium dioxide II is rutile type, and the particle size range is 100-500nm.

Preferably, the titanium dioxide I, the zinc oxide and the titanium dioxide II are all powder subjected to surface treatment, and the surface coating agent is nano silicon dioxide.

The nano titanium dioxide has strong photocatalytic activity, and can be directly used in cosmetics, and the free radicals generated after the nano titanium dioxide absorbs ultraviolet rays can accelerate skin aging and cause damage to the skin, so that the surface of the nano titanium dioxide needs to be modified, namely a layer of substance is coated on the surface of the nano titanium dioxide. According to the invention, the silicon dioxide is used for treating the powder, so that ultraviolet rays reaching titanium dioxide particles are reduced, the absorption of the titanium dioxide to the ultraviolet rays is reduced, the dispersing capacity of the titanium dioxide particles can be increased, the product stability is improved, and the retention amount during introduction is ensured.

Preferably, the mass ratio of the titanium dioxide I to the titanium dioxide II is 1.

Preferably, the pearl powder is prepared by crushing seawater pearls through an ultrafine powder processing technology, and the particle size of the pearl powder is less than 120000 meshes.

The pearl powder is rich in 18 amino acids, wherein 7 amino acids are essential for human body, calcium carbonate with aragonite structure, and more than 20 microelements and vitamins, and has effects of nourishing skin, whitening skin, removing speckle, controlling oil and astringing.

Preferably, the thickening agent is one or more of guar gum, xanthan gum and carbomer.

Preferably, the preservative is one or more of 1,2 pentanediol, phenoxyethanol/ethylhexyl glycerol, 1,2 hexanediol/caprylyl hydroximic acid/ethylhexyl glycerol.

Preferably, the preparation method of the rejuvenating, skin-brightening and youthful-keeping foundation solution comprises the following steps: 1. taking one part of the thickening agent, slowly pouring the thickening agent into more than ten parts of pure water with the temperature of 30-35 ℃ while stirring, soaking for about two hours, and continuously stirring until the thickening agent is completely dissolved to prepare uniform colloid for later use; 2. putting titanium dioxide I, titanium dioxide II, pearl powder and pure water into a stirring pot at 30-35 ℃, putting into an ultrasonic processor, and stirring for 5 minutes while carrying out ultrasonic treatment to prepare dispersion liquid of the main material; 3. adding glycerol and sodium hyaluronate into the dispersion prepared in the previous step, and continuing to stir for 5 minutes while carrying out ultrasonic treatment; 4. adding the preservative, and continuously stirring and ultrasonically treating for 2 minutes; 5. finally, adding the thickener colloid prepared in the first step, and continuing stirring for 5 minutes; cooling to room temperature and discharging.

Compared with the prior art, the formula for the reversible change of the non-permanent skin provided by the invention has the beneficial effects that: 1, the operation is simple and convenient; 2. the trouble of makeup and makeup removal can be avoided; 3. can maintain the makeup stability for a long time without frequent makeup; 4. the medicine is painless, noninvasive, safe and efficient; 5. the makeup can disappear automatically along with the time, and the corresponding average introduction depth can be selected according to the time for maintaining the makeup.

Detailed Description

The present invention will be further described with reference to specific embodiments for better illustrating the objects, technical solutions and advantages of the present invention.

(I) rejuvenating, brightening and retaining youthful looks foundation liquid experiment:

example 1

A composition with non-permanent reversible skin change comprises at least one nanometer wafer and/or microneedle introducing instrument, and skin-whitening and skin-caring foundation solution; the rejuvenating, skin-brightening and youthful-look-retaining liquid foundation comprises the following components in percentage by mass: 2.5% of titanium dioxide I, 9% of titanium dioxide II, 3.5% of pearl powder, 12% of glycerol, 8.5% of sodium hyaluronate, 0.3% of carbomer, 0.4% of phenoxyethanol/ethylhexyl glycerol and the balance of water; the titanium dioxide I and the titanium dioxide II are both powder subjected to surface treatment, and the surface coating agent is nano silicon dioxide; the nano-chip leading-in instrument leads the rejuvenating, brightening and retaining powder base solution into the superficial layer of the skin, and the average depth of the base solution is 20 microns.

Example 2

A composition with non-permanent reversible skin change comprises at least one nanometer wafer and/or microneedle introducing instrument, and skin-whitening and skin-caring foundation solution; the face-refreshing, skin-brightening and youthful-keeping foundation solution comprises the following components in percentage by mass: 4.5% of titanium dioxide I, 7% of titanium dioxide II, 5.5% of pearl powder, 16.5% of glycerol, 5% of sodium hyaluronate, 0.45% of xanthan gum, 0.5% of 1, 2% of hexanediol/caprylyl hydroximic acid/ethylhexyl glycerol and the balance of water; the titanium dioxide I and the titanium dioxide II are both powder subjected to surface treatment, and the surface coating agent is nano silicon dioxide; the nano-chip leading-in instrument leads the rejuvenating, brightening and retaining powder base solution into the superficial layer of the skin, and the average depth of the base solution is 20 microns.

Example 3

A composition with non-permanent reversible skin change comprises at least one nanometer wafer and/or microneedle introducing instrument, and skin-whitening and skin-caring foundation solution; the rejuvenating, skin-brightening and youthful-look-retaining liquid foundation comprises the following components in percentage by mass: 6.5% of titanium dioxide I, 5% of titanium dioxide II, 7.5% of pearl powder, 15% of glycerol, 6.5% of sodium hyaluronate, 0.45% of guar gum, 0.6% of 1,2 pentanediol and the balance of water; the titanium dioxide I and the titanium dioxide II are both powder subjected to surface treatment, and the surface coating agent is nano silicon dioxide; the nano-chip leading-in instrument leads the skin-refreshing, skin-brightening and skin-retaining liquid foundation into the superficial layer of the skin, and the average depth of the liquid foundation is 20 micrometers.

Example 4

A composition with reversible change of non-permanent skin comprises at least one nanometer wafer and/or micro-needle introduction instrument, and skin whitening and skin caring foundation solution; the rejuvenating, skin-brightening and youthful-look-retaining liquid foundation comprises the following components in percentage by mass: 8.5% of titanium dioxide I, 3% of titanium dioxide II, 6% of pearl powder, 10% of glycerol, 11% of sodium hyaluronate, 0.35% of xanthan gum, 0.2% of 1,2 pentanediol, 0.3% of phenoxyethanol/ethylhexyl glycerol and the balance of water; the titanium dioxide I and the titanium dioxide II are both powder subjected to surface treatment, and the surface coating agent is nano silicon dioxide; the nano-chip leading-in instrument leads the rejuvenating, brightening and retaining powder base solution into the superficial layer of the skin, and the average depth of the base solution is 20 microns.

Example 5

A composition with non-permanent reversible skin change comprises at least one nanometer chip leading-in instrument and skin-whitening and skin-retaining foundation solution; the face-refreshing, skin-brightening and youthful-keeping foundation solution comprises the following components in percentage by mass: 10.5% of titanium dioxide I, 0.5% of titanium dioxide II, 7% of pearl powder, 13% of glycerol, 8% of sodium hyaluronate, 0.3% of xanthan gum, 0.5% of 1, 2% of hexanediol/caprylyl hydroximic acid/ethylhexyl glycerol and the balance of water; the titanium dioxide I and the titanium dioxide II are both powder subjected to surface treatment, and the surface coating agent is nano silicon dioxide; the nano-chip leading-in instrument leads the rejuvenating, brightening and retaining powder base solution into the superficial layer of the skin, and the average depth of the base solution is 20 microns.

Example 6

A composition with non-permanent reversible skin change comprises at least one nanometer wafer and/or microneedle introducing instrument, and skin-whitening and skin-caring foundation solution; the face-refreshing, skin-brightening and youthful-keeping foundation solution comprises the following components in percentage by mass: 0.5% of titanium dioxide I, 10.5% of titanium dioxide II, 5% of pearl powder, 15% of glycerol, 6% of sodium hyaluronate, 0.55% of carbomer, 0.4% of phenoxyethanol/ethylhexyl glycerol and the balance of water; the titanium dioxide I and the titanium dioxide II are both powder subjected to surface treatment, and the surface coating agent is nano silicon dioxide; the nano-chip leading-in instrument leads the rejuvenating, brightening and retaining powder base solution into the superficial layer of the skin, and the average depth of the base solution is 20 microns.

The implementation method of the whitening and skin-brightening skin-retaining foundation solution of the above examples 1 to 6 is as follows: 1. uniformly applying the foundation liquid for brightening skin and retaining youthful looks to the cheek parts of normal people; 2. uniformly and point-lifting and introducing a nano-chip introducing instrument in a region where the face-brightening, skin-brightening and youthful-keeping powder base solution is smeared, wherein the introducing time of the whole face part is about 2 minutes; 3. after the introduction is finished, standing for about 3 minutes, and gently washing off foundation substrate remained on the face by using clear water; 4. photographing, instrumental detection and sensory evaluation recording.

Comparative example 1

The difference from example 2 is that: the introduction was not carried out after the application.

Comparative example 2

The difference from example 3 is that: introduction was not carried out after application.

Comparative example 3

One commercially available mild liquid foundation: the application was followed by introduction, the embodiment being identical to examples 1 to 6.

Comparative example 4

The difference from comparative example 3 is that: the introduction was not carried out after the application.

Sensory evaluation

1. The test substance: liquid foundations obtained in examples 1 to 6 and comparative examples 1 to 4.

2. Subject: the total number of 30 persons, 15 persons in male and 15 persons in female, the age is 21-49 years, and the volunteer enrollment criteria of the subject are met.

3. The evaluation method comprises the following steps: 1g of sample is taken to be smeared on the face, and after the operation steps of examples 1-6 and comparative examples 1-4 are carried out, the scores are added in a scoring mode (the higher the score is, the better the texture, spreadability, smoothness, fitness, after-use comfort, skin whiteness and skin elasticity of the product are represented), and the higher the value is, the better the product performance is.

TABLE 1

Sensory evaluation results: the scores of the combined subjects after smearing and introduction were counted, and the results are shown in table 1. It can be seen that the foundation solutions of patent examples 1 to 6 of the present invention are superior to the comparative examples in texture, spreadability, smoothness, conformability, comfort after use, skin whiteness, and skin elasticity.

Compared with the examples 2 to 3, the comparative examples 1 to 2 show that the whitening and skin-brightening and youthful-keeping foundation liquid can obviously improve the whiteness and elasticity of the skin through a microcrystalline introduction mode, and brings the effects of skin brightening and nourishing.

Compared with the examples 1 to 6, the comparative examples 3 to 4 show that the whitening and skin-brightening and youthful-look-retaining foundation liquid disclosed by the application has better skin whitening and elasticity improving effects than the foundation liquid on the market after being introduced; the commercial liquid foundation cannot stay in the stratum corneum due to its large particle size, and contains a large amount of components unsuitable for introduction, which may cause adverse effects.

Assessment of age-keeping

The test substance: foundation solutions obtained in examples 1 to 6 and comparative examples 1 to 4, and methods of introduction.

Subject: the total 10 persons, 5 men and 5 women, the age is 21-49 years, and the volunteer enrollment criteria of the subject are met.

The evaluation method comprises the following steps: after 1g of the sample was applied to the face, the change in skin whiteness was measured with a skin measuring device every day at intervals of 1 day after the procedures of examples 1 to 6 and comparative examples 1 to 4, and the number of individuals who maintained and recovered the whiteness of the sample every day after the application was counted.

TABLE 2

Assessment of appearance-retaining aging results: statistics of the time-dependent decay of skin whiteness of the subjects after application and introduction are shown in Table 2. Therefore, in patent examples 1-6 of the invention, more whiteness of the subjects still stays in days 4-5, and the subjects recover the state before implementation after day 6, so that semi-permanent whitening and youthful looks keeping for days 4-5 are realized.

Compared with the examples 2-3, the comparative examples 1-2 and the examples 2-3 show that the rejuvenating, brightening and youthful skin-retaining foundation liquid can obviously improve the retention time of whiteness of skin in a microcrystalline introduction mode, and semi-permanent youthful skin retention for 4-5 natural days is realized.

As can be seen from comparison of comparative examples 3-4 with examples 1-6, the commercial foundation liquid coating can only be maintained for about 1 day; the nano-chip introduction can be maintained for 3-4 days. The products of examples 1-6 had significantly better appearance retention and aging than the commercial products.

(II) tattoo dye liquor maintaining time test:

example 7

A formula for non-permanent reversible skin change comprises at least one nano-chip leading-in instrument and tattoo dye solution; the average depth of tattoo dye solution introduced into the skin cortex by the nano-chip introducer was 30 μm.

Example 8

A formula for non-permanent reversible skin change comprises at least one nano-chip leading-in instrument and tattoo dye solution; the average depth of tattoo dye solution introduced into the skin cortex by the nano-chip introducer was 70 μm.

Example 9

A formula for non-permanent reversible skin change comprises at least one nano-chip leading-in instrument and tattoo dye solution; the average depth of tattoo dye solution introduced into the skin cortex by the nano-chip introducer was 120 μm.

Comparative example 5

The differences from examples 7 to 9 are: the injection is performed in the dermis layer.

Examples 7-9 above the formulation of the reversible change in non-permanent skin was carried out as follows: 1. the tattoo dye solution is evenly smeared on the arm parts of normal people; 2. a nanometer wafer lead-in instrument is selected to uniformly point-extract and lead in a region coated with tattoo dye liquor, and the lead-in time of the whole arm test part is about 1 minute; 3. after the introduction is finished, standing for about 5 minutes, and gently washing away the tattooing dye solution remained on the tested part by using clear water; 4. photographing, detecting by an instrument and recording.

Evaluation of dyeing aging

The test substance: tattoo dye liquor.

Subject: the total number of 30 persons, 15 persons in male and 15 persons in female, the age is 21-49 years, and the volunteer enrollment criteria of the subject are met.

The evaluation method comprises the following steps: 0.2g of body dyeing liquid is smeared on an arm testing part, after the operation steps of examples 7-9 and comparative example 5 are carried out, the skin color change condition of the testing part is detected by a skin detector every day at intervals of 10 days, and the number of individuals of the sample with color maintenance and recovery every day after implementation is counted.

TABLE 3

TABLE 3 continuation of the table

Evaluation result of dyeing aging: statistics of the time-dependent decay of skin color of the subjects after application and introduction are shown in Table 3. It can be seen that patent examples 7-9 of the present invention all have color resident at day 10, and then gradually recover to the pre-applied state at different times according to the difference of the average introduction depth, thereby realizing the reversible change of the non-permanent skin within a certain time.

Comparing examples 7-9 with comparative example 5, it can be seen that the present application of tattoo dye solutions via microcrystalline introduction allows for non-permanent reversible skin changes in the skin; the skin is permanently changed in appearance by injecting a tattoo into the dermis.

(III) hyaluronic acid wrinkle-removing experiment:

example 10

A composition for non-permanent reversible skin changes comprises at least one nano-chip and/or micro-needle introduction instrument, and low molecular weight hyaluronic acid; the average depth of the small molecular weight hyaluronic acid introduced into the skin cortex of the left canthus of the subject is 70 microns by a nano-chip introduction instrument.

Example 11

A composition for non-permanent reversible skin changes comprises at least one nano-chip and/or micro-needle introduction instrument, and medium molecular weight hyaluronic acid; the average depth of the hyaluronic acid with medium molecular weight introduced into the skin cortex of the right canthus of the affected person by the nano-chip introducing instrument is 70 microns.

Examples 10 to 11 differ in that: hyaluronic acid varies in molecular weight and in the site to be tested.

The above examples 10-11 are examples of formulations for reversible modification of non-permanent skin as follows: 1. evenly smearing hyaluronic acid on the human eye pattern; 2. uniformly and point-lifting and guiding in a hyaluronic acid coating area by using a nano-chip guiding instrument, wherein the guiding time of the whole test part is about 15 seconds; 3. after the introduction is finished, after standing for about 20 minutes, slightly washing away hyaluronic acid remained at the tested part by using clear water; 4. and taking pictures and recording instrument detection.

Wrinkle removal aging evaluation:

the test substance: low and medium molecular weight hyaluronic acid.

Subject: the age of 1 person is 50 years, the grades of the canthus striatus of the left eye and the right eye are the same, and the voluntary enrollment criteria of the testee are met.

The evaluation method comprises the following steps: firstly, photographing a part to be tested, and then selecting 0.05ml of low-molecular-weight hyaluronic acid to be smeared on a left canthus testing part of a testee; 0.05ml of medium molecular weight hyaluronic acid was smeared on the right corner of the eye of a subject, and after the procedure of examples 10 to 11, the test site was photographed at specified intervals (three times per photograph), and the change in wrinkles on the skin at the test site was quantified by using the Visioscan VC98 (CK Electronic G mbH, germany) in the image analyzer and the SEW parameter item in the SELS parameter in the apparatus (averaging SEW parameters for 3 photographs at a time), and the corresponding wrinkle grades were recorded (skin grade was 9, the best skin was 9, and the worst skin was 1).

TABLE 4

And (4) ageing evaluation results: the results of the rating recordings of the skin wrinkles of the subjects after application and introduction over time are shown in table 4. It can be seen from the above data that the data of patent examples 10-11 of the present invention indicate that the present invention can be used for the introduction of hyaluronic acid, and has a significant effect on wrinkle removal of skin, the time maintenance of wrinkle removal is determined by the properties of hyaluronic acid, and the longer the molecular weight is, the longer the time maintenance of wrinkle removal is. With the lapse of time, hyaluronic acid is absorbed and metabolized by the skin, and the skin gradually recovers the state before implementation, realizing the non-permanent reversible change of the skin within a certain time.

The foregoing shows and describes the general principles, principal features and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are given by way of illustration of the principles of the present invention, and that various changes and modifications may be made without departing from the spirit and scope of the invention as defined by the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. A composition for reversible alteration of non-permanent skin, comprising: comprises at least one nano-chip and/or micro-needle leading-in instrument and at least one cosmetic formula; the nano wafer and/or the micro needle introduction instrument is used for opening an introduction channel on the skin surface layer so as to facilitate the introduction of the beauty treatment formula into the skin surface layer.

2. The formulation of claim 1, wherein the formulation is for reversible modification of semipermanent skin: the depth of the makeup formula introduced into the superficial layer of the skin is 0-1500 microns; preferably, the cosmetic formulation is introduced into the superficial skin layer to a depth of preferably 1 to 500 microns.

3. The formulation of claim 1, wherein the formulation is for reversible modification of semipermanent skin: the makeup formula is one or more of body tattooing dye solution, eyebrow tattooing dye solution, lip color, eye shadow, facial foundation, facial makeup, hyaluronic acid, cross-linked hyaluronic acid, collagen and human-like collagen.

4. A formulation of reversible changes in semipermanent skin according to claim 3, characterized in that: the facial foundation is a foundation liquid for beautifying, brightening and retaining youthful looks; the face-brightening skin-retaining face-beautifying liquid foundation at least comprises: a sun-screening component, a whitening and skin-nourishing component, a humectant II, a thickening agent, a preservative and water.

5. The composition of claim 4, wherein the composition comprises: the rejuvenating, skin-brightening and youthful-keeping foundation liquid comprises the following components in percentage by mass: 1 to 8 weight percent of sunscreen component, 2 to 10 weight percent of whitening component, 1 to 10 weight percent of whitening and skin-nourishing component, 1 to 20 weight percent of humectant I, 1 to 10 weight percent of humectant II, 0.2 to 1 weight percent of thickening agent, 0.4 to 1.6 weight percent of preservative and the balance of water.

6. A formulation of reversible changes in semipermanent skin, according to claim 5, characterized in that: the sunscreen component is one or more of titanium dioxide I, zinc oxide, cerium oxide, hydroxy pinacolone retinoic acid ester, lotus flower extract for enhancing mitochondrion autophagy and vascular endothelial growth factor, the whitening component is titanium dioxide II, the whitening and skin-nourishing component is pearl powder, the humectant I is glycerol, and the humectant II is sodium hyaluronate.

7. The composition of claim 6, wherein the composition comprises: the titanium dioxide I is rutile type, and the particle size range is 1-100nm; the titanium dioxide II is rutile type, and the particle size range is 100-500nm; preferably, the titanium dioxide I and the titanium dioxide II are both powder subjected to surface treatment, and the surface coating agent is nano silicon dioxide; preferably, the mass ratio of the titanium dioxide I to the titanium dioxide II is 1.

8. The composition of claim 6, wherein the composition comprises: the pearl powder is prepared by crushing seawater pearl by superfine powder processing technology, and the particle size is less than 120000 meshes.

9. The composition of claim 4, wherein the composition comprises: the thickening agent is one or more of guar gum, xanthan gum and carbomer; the preservative is one or more of 1,2 pentanediol, phenoxyethanol/ethylhexyl glycerin, 1,2 hexanediol/caprylyl hydroximic acid/ethylhexyl glycerin.