CN115227787A - Traditional Chinese medicine composition for treating acute tonsillitis and application thereof - Google Patents

Traditional Chinese medicine composition for treating acute tonsillitis and application thereof Download PDF

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Publication number
CN115227787A
CN115227787A CN202211007905.2A CN202211007905A CN115227787A CN 115227787 A CN115227787 A CN 115227787A CN 202211007905 A CN202211007905 A CN 202211007905A CN 115227787 A CN115227787 A CN 115227787A
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traditional chinese
chinese medicine
medicine composition
radix
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谢洋
李素云
王明航
杨建雅
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First Affiliated Hospital of Henan University of TCM
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First Affiliated Hospital of Henan University of TCM
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Abstract

The invention provides a traditional Chinese medicine composition for treating acute tonsillitis, which comprises the following raw materials in parts by weight: 10-20 parts of wild chrysanthemum flower, 10-20 parts of honeysuckle flower, 10-20 parts of Chinese violet, 10-20 parts of chingma abutilon seed, 10-20 parts of dandelion, 5-15 parts of angelica dahurica, 20-40 parts of herba patriniae, 20-40 parts of coix seed, 10-20 parts of moutan bark, 8-16 parts of rhizoma acori graminei, 4-8 parts of blackberry lily, 5-10 parts of platycodon grandiflorum, 5-9 parts of burdock fruit and 5-9 parts of liquorice. The traditional Chinese medicine composition for treating acute tonsillitis provided by the invention is reasonable and balanced in preparation, all raw materials act synergistically, can treat both symptoms and root causes, clear away heat and toxic materials, nourish yin to moisten dryness, activate blood to reduce swelling, and has no toxic or side effect.

Description

Traditional Chinese medicine composition for treating acute tonsillitis and application thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating acute tonsillitis and application thereof.
Background
Acute tonsillitis is a nonspecific acute inflammation of palatine tonsil, and is a common clinical disease of inflammation of pharyngeal tonsil. It is mainly caused by bacterial infection of beta hemolytic streptococcus, staphylococcus, pneumococcus and the like, has intolerable pharyngalgia during disease attack, is often radiated to ears, and is also accompanied with symptoms of hoarseness, dysphagia, red tongue with yellow coating, inappetence and the like. If the treatment is not timely, the general symptoms such as chills, high fever and headache can be caused.
At present, most of modern medicine for treating acute tonsillitis adopts medicines such as antibiotics and the like, although the medicines have certain curative effect, the side effect is large, the medicines are difficult to be thoroughly cured, the tonsillitis is easy to recur, tonsil extirpation operation has to be carried out in serious cases, and antibiotic medicines are used for a long time, and part of patients can have antibiotic dependence or antibiotic drug resistance.
Disclosure of Invention
In view of the above, the technical problem to be solved by the invention is to provide a traditional Chinese medicine composition for treating acute tonsillitis and an application thereof, the traditional Chinese medicine composition for treating acute tonsillitis provided by the invention has the advantages of abundant raw materials, scientific and reasonable formula, synergistic effect of the raw materials, treatment of both symptoms and root causes, heat clearing and detoxifying, yin nourishing and dryness moistening, blood circulation promoting and swelling diminishing, no toxic or side effect, good curative effect, quick response, strong drug effect, difficult relapse and the like in the aspect of treating acute tonsillitis.
The invention provides a traditional Chinese medicine composition for treating acute tonsillitis, which comprises the following raw materials in parts by weight: 10-20 parts of wild chrysanthemum flower, 10-20 parts of honeysuckle flower, 10-20 parts of Chinese violet, 10-20 parts of malva seed, 10-20 parts of dandelion, 5-15 parts of angelica dahurica, 20-40 parts of dahurian patrinia herb, 20-40 parts of coix seed, 10-20 parts of tree peony bark, 8-16 parts of grassleaf sweelflag rhizome, 4-8 parts of blackberry lily, 5-10 parts of platycodon root, 5-9 parts of great burdock achene and 5-9 parts of liquorice.
Preferably, the raw materials comprise the following components in parts by weight:
10 parts of wild chrysanthemum flower, 10 parts of honeysuckle flower, 10 parts of Chinese violet, 10 parts of cluster mallow fruit, 10 parts of dandelion, 5 parts of angelica dahurica, 20 parts of dahurian patrinia herb, 20 parts of coix seed, 10 parts of tree peony bark, 8 parts of grassleaf sweelflag rhizome, 4 parts of blackberry lily, 5 parts of platycodon root, 5 parts of great burdock achene and 6 parts of liquorice.
Preferably, the raw materials comprise the following components in parts by weight:
15 parts of wild chrysanthemum flower, 15 parts of honeysuckle flower, 15 parts of Chinese violet, 15 parts of malva seed, 15 parts of dandelion, 10 parts of angelica dahurica, 30 parts of patrinia, 30 parts of coix seed, 15 parts of moutan bark, 10 parts of grassleaf sweelflag rhizome, 6 parts of blackberry lily, 10 parts of platycodon root, 6 parts of great burdock achene and 6 parts of liquorice.
Preferably, the raw materials comprise the following components in parts by weight:
20 parts of wild chrysanthemum flower, 20 parts of honeysuckle flower, 20 parts of Chinese violet, 20 parts of malva seed, 20 parts of dandelion, 15 parts of angelica dahurica, 40 parts of dahurian patrinia herb, 40 parts of coix seed, 20 parts of tree peony bark, 16 parts of grassleaf sweelflag rhizome, 8 parts of blackberry lily, 10 parts of platycodon root, 9 parts of great burdock achene and 9 parts of liquorice.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating and/or preventing acute tonsillitis.
Preferably, the medicament is selected from powder, capsules or decoction.
Preferably, the powder is prepared according to the following method:
respectively drying flos Chrysanthemi Indici, flos Lonicerae, herba Violae, semen Abutili, herba Taraxaci, radix Angelicae Dahuricae, herba Patriniae, coicis semen, cortex moutan, rhizoma Acori Graminei, rhizoma Belamcandae, radix Platycodi, fructus Arctii and Glycyrrhrizae radix, mixing, grinding into powder, and sieving to obtain Chinese medicinal powder.
Preferably, the capsule is prepared according to the following method:
respectively drying flos Chrysanthemi Indici, flos Lonicerae, herba Violae, semen Abutili, herba Taraxaci, radix Angelicae Dahuricae, herba Patriniae, coicis semen, cortex moutan, rhizoma Acori Graminei, rhizoma Belamcandae, radix Platycodi, fructus Arctii and Glycyrrhrizae radix, mixing, grinding into powder, and sieving to obtain Chinese medicinal powder;
and filling the traditional Chinese medicine powder into a capsule shell to obtain the capsule.
Preferably, the decoction is prepared according to the following method:
a) Mixing flos Chrysanthemi Indici, flos Lonicerae, herba Violae, semen Abutili, herba Taraxaci, radix Angelicae Dahuricae, herba Patriniae, coicis semen, cortex moutan, rhizoma Acori Graminei, rhizoma Belamcandae, radix Platycodi, fructus Arctii and Glycyrrhrizae radix with water, and heating and extracting to obtain extract;
b) Performing solid-liquid separation on the extract to obtain medicine residues and an extracting solution;
c) Mixing the medicine residues with water, heating and extracting, and performing solid-liquid separation to obtain an extracting solution;
d) Mixing the extractive solution obtained in step B) with the extractive solution obtained in step C) to obtain decoction.
Compared with the prior art, the invention provides a traditional Chinese medicine composition for treating acute tonsillitis, which comprises the following raw materials in parts by weight: 10-20 parts of wild chrysanthemum flower, 10-20 parts of honeysuckle flower, 10-20 parts of Chinese violet, 10-20 parts of chingma abutilon seed, 10-20 parts of dandelion, 5-15 parts of angelica dahurica, 20-40 parts of herba patriniae, 20-40 parts of coix seed, 10-20 parts of moutan bark, 8-16 parts of rhizoma acori graminei, 4-8 parts of blackberry lily, 5-10 parts of platycodon grandiflorum, 5-9 parts of burdock fruit and 5-9 parts of liquorice. The traditional Chinese medicine composition for treating acute tonsillitis provided by the invention is reasonable and balanced in preparation, all raw materials act synergistically, can treat both symptoms and root causes, clear away heat and toxic materials, nourish yin to moisten dryness, activate blood to reduce swelling, and has no toxic or side effect.
Detailed Description
The invention provides a traditional Chinese medicine composition for treating acute tonsillitis, which comprises the following raw materials in parts by weight: 10-20 parts of wild chrysanthemum flower, 10-20 parts of honeysuckle flower, 10-20 parts of Chinese violet, 10-20 parts of chingma abutilon seed, 10-20 parts of dandelion, 5-15 parts of angelica dahurica, 20-40 parts of herba patriniae, 20-40 parts of coix seed, 10-20 parts of moutan bark, 8-16 parts of rhizoma acori graminei, 4-8 parts of blackberry lily, 5-10 parts of platycodon grandiflorum, 5-9 parts of burdock fruit and 5-9 parts of liquorice.
The traditional Chinese medicine composition for treating acute tonsillitis provided by the invention comprises 10-20 parts of wild chrysanthemum flower, preferably 10, 12, 14, 15, 16, 18, 20, or any value between 10-20 parts. In the present invention, wild chrysanthemum: bitter and pungent in property and slightly cold in nature. It enters liver and heart meridians. The function is mainly used for clearing away heat and toxic materials. Can be used for treating furuncle, carbuncle, swelling, conjunctival congestion, swelling and pain, headache, and vertigo.
The traditional Chinese medicine composition for treating acute tonsillitis provided by the invention also comprises 10-20 parts of honeysuckle, preferably 10, 12, 14, 15, 16, 18, 20, or any value between 10-20 parts. In the present invention, honeysuckle: sweet in nature and taste and cold in nature. It enters lung, heart and stomach meridians. The functions are mainly used for clearing away heat and toxic materials and cooling and dispersing wind heat. Can be used for treating carbuncle, furuncle, sore throat, erysipelas, toxic heat, dysentery, wind-heat type common cold, epidemic febrile disease, and fever.
The traditional Chinese medicine composition for treating acute tonsillitis provided by the invention also comprises 10-20 parts of Chinese violet, preferably 10, 12, 14, 15, 16, 18 and 20, or any value between 10-20 parts. In the invention, the Chinese violet: bitter, pungent and cold in nature. It enters heart and liver meridians. The functions are mainly to clear away heat and toxic material, cool blood and relieve swelling. Can be used for treating furuncle, pyogenic infection, carbuncle, cellulitis, carbuncle, erysipelas, and snake bite.
The traditional Chinese medicine composition for treating acute tonsillitis provided by the invention also comprises 10-20 parts of cluster mallow seeds, preferably 10, 12, 14, 15, 16, 18, 20, or any value between 10-20 parts. In the present invention, cluster mallow: sweet in nature and taste, cold in nature. Enter the large and small intestine and bladder meridians. The functions are mainly used for promoting diuresis, lubricating intestines and promoting lactation. It is indicated for obstruction of urination and defecation, gonorrhea, edema, female milk obstruction, and breast swelling and pain.
The traditional Chinese medicine composition for treating acute tonsillitis provided by the invention also comprises 10-20 parts of dandelion, preferably 10, 12, 14, 15, 16, 18, 20, or any value between 10-20 parts. In the present invention, dandelion: bitter, sweet and cold in nature. They enter liver and stomach meridians. The functions are mainly used for clearing away heat and toxic material, reducing swelling and resolving masses, and inducing diuresis for treating stranguria. Can be used for treating furuncle, pyogenic infection, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat pathogen, and stranguria with damp-heat pathogen.
The traditional Chinese medicine composition for treating acute tonsillitis further comprises 5-15 parts of radix angelicae, preferably 5, 7, 9, 10, 12, 14, 15, or any value between 5-15 parts. In the invention, radix angelicae: pungent and warm in nature and flavor. It enters stomach, large intestine and lung meridians. The functions are mainly used for dispelling wind and eliminating dampness, dredging orifices and relieving pain, and reducing swelling and expelling pus. Can be used for treating common cold, headache, supra-orbital bone pain, nasal obstruction, nasosinusitis, toothache, leukorrhagia, and pyocutaneous disease with swelling and pain.
The traditional Chinese medicine composition for treating acute tonsillitis further comprises 20-40 parts of herba patriniae, preferably 20, 25, 30, 35, 40 or any value between 20-40 parts. In the present invention, herba patriniae: pungent, bitter and cool in nature. Enter stomach, large intestine and liver meridians. The functions are mainly used for clearing away heat and toxic material, eliminating carbuncle and expelling pus, and promoting blood circulation and removing blood stasis. Can be used for treating abdominal pain, pain in chest and abdomen due to excessive heat and blood stasis, and puerperal abdominal pain due to intestinal carbuncle, pulmonary abscess, sore, carbuncle, and toxic swelling.
The traditional Chinese medicine composition for treating acute tonsillitis further comprises 20-40 parts of coix seeds, preferably 20, 25, 30, 35, 40 or any value between 20-40 parts. In the present invention, coix seed: sweet, light and cool in nature and taste. It enters spleen, stomach and lung meridians. The functions are mainly used for strengthening spleen and excreting dampness, eliminating arthralgia and checking diarrhea, clearing heat and expelling pus. Can be used for treating edema, loempe, dysuresia, damp arthralgia, spasm, spleen deficiency, diarrhea, pulmonary abscess, and intestinal abscess; flat warts.
The traditional Chinese medicine composition for treating acute tonsillitis provided by the invention also comprises 10-20 parts of moutan bark, preferably 10, 12, 14, 15, 16, 18, 20, or any value between 10-20 parts. In the present invention, moutan bark: bitter and pungent in property and slightly cold in nature. It enters heart, liver and kidney meridians. The functions are mainly used for clearing heat and cooling blood, and promoting blood circulation and removing blood stasis. Can be used for treating macula due to toxic heat, hematemesis, epistaxis, nocturnal fever, morning coldness, no sweating, hectic fever, dysmenorrhea due to amenorrhea, carbuncle, swelling, skin sore, and traumatic injury.
The traditional Chinese medicine composition for treating acute tonsillitis provided by the invention also comprises 8-16 parts of rhizoma acori graminei, preferably 8, 10, 12, 14 and 16, or any value between 8-16 parts. In the present invention, grassleaf sweelflag rhizome: pungent, bitter and warm in nature. It enters heart and stomach meridians. The functions are mainly used for eliminating dampness, stimulating appetite, inducing resuscitation, eliminating phlegm, refreshing mind and benefiting intelligence. Can be used for treating epigastric fullness, inappetence, dysentery, coma, epilepsy, amnesia, and deafness.
The traditional Chinese medicine composition for treating acute tonsillitis provided by the invention also comprises 4-8 parts of blackberrykiky rhizome, preferably 4, 5, 6, 7, 8, or any value between 4-8 parts. In the invention, the blackberrylily rhizome is bitter and cold in nature. It enters lung meridian. The functions are mainly used for clearing away heat and toxic material, eliminating phlegm and relieving sore throat. Can be used for treating stagnation of heat-toxin and phlegm-fire, sore throat, excessive phlegm and saliva, cough and asthma.
The traditional Chinese medicine composition for treating acute tonsillitis further comprises 5-10 parts of platycodon grandiflorum, preferably 5, 6, 7, 8, 9, 10 or any value between 5-10 parts. In the invention, the balloonflower root is bitter, pungent and mild in nature and taste. It enters lung meridian. The functions are mainly used for dispersing lung qi, relieving sore throat, eliminating phlegm and expelling pus. Can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, lung carbuncle, suppuration, and pyocutaneous disease with pus formation.
The traditional Chinese medicine composition for treating acute tonsillitis further comprises 5-9 parts of burdock, preferably 5, 6, 7, 8, 9, or any value between 5-9 parts. In the invention, the burdock is pungent, bitter and cold in nature. It enters lung and stomach meridians. The functions are mainly to disperse wind and heat, ventilate lung and promote eruption, detoxify and relieve sore throat. Can be used for treating wind-heat type common cold, cough with excessive phlegm, measles, rubella, sore throat, mumps, erysipelas, carbuncle, swelling, and suppurative sore.
The traditional Chinese medicine composition for treating acute tonsillitis further comprises 5-9 parts of liquorice, preferably 5, 6, 7, 8, 9 or any value between 5-9 parts. In the invention, the liquorice has sweet and mild nature and taste. It enters heart, lung, spleen and stomach meridians. The functions are mainly used for tonifying spleen and qi, clearing heat and detoxicating, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing the medicines. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.
In some specific embodiments of the present invention, the traditional Chinese medicine composition for treating acute tonsillitis comprises the following raw materials, by weight:
10 parts of wild chrysanthemum flower, 10 parts of honeysuckle flower, 10 parts of Chinese violet, 10 parts of malva seed, 10 parts of dandelion, 5 parts of angelica dahurica, 20 parts of dahurian patrinia herb, 20 parts of coix seed, 10 parts of tree peony bark, 8 parts of grassleaf sweelflag rhizome, 4 parts of blackberry lily, 5 parts of platycodon root, 5 parts of great burdock achene and 6 parts of liquorice.
In some specific embodiments of the present invention, the traditional Chinese medicine composition for treating acute tonsillitis comprises the following raw materials, by weight:
15 parts of wild chrysanthemum flower, 15 parts of honeysuckle flower, 15 parts of Chinese violet, 15 parts of cluster mallow seed, 15 parts of dandelion, 10 parts of angelica dahurica, 30 parts of dahurian patrinia herb, 30 parts of coix seed, 15 parts of tree peony bark, 10 parts of grassleaf sweelflag rhizome, 6 parts of blackberry lily, 10 parts of platycodon root, 6 parts of great burdock achene and 6 parts of liquorice.
In some specific embodiments of the present invention, the traditional Chinese medicine composition for treating acute tonsillitis comprises the following raw materials, by weight:
20 parts of wild chrysanthemum flower, 20 parts of honeysuckle flower, 20 parts of Chinese violet, 20 parts of malva seed, 20 parts of dandelion, 15 parts of angelica dahurica, 40 parts of dahurian patrinia herb, 40 parts of coix seed, 20 parts of tree peony bark, 16 parts of grassleaf sweelflag rhizome, 8 parts of blackberry lily, 10 parts of platycodon root, 9 parts of great burdock achene and 9 parts of liquorice.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating and/or preventing acute tonsillitis.
Wherein, the medicine is selected from powder, capsules or decoction.
Wherein the powder is prepared according to the following method:
respectively drying flos Chrysanthemi Indici, flos Lonicerae, herba Violae, semen Abutili, herba Taraxaci, radix Angelicae Dahuricae, herba Patriniae, coicis semen, cortex moutan, rhizoma Acori Graminei, rhizoma Belamcandae, radix Platycodi, fructus Arctii and Glycyrrhrizae radix, mixing, grinding into powder, and sieving to obtain Chinese medicinal powder. Wherein the sieving is 80-100 mesh sieving.
The capsules were prepared as follows:
respectively drying flos Chrysanthemi Indici, flos Lonicerae, herba Violae, semen Abutili, herba Taraxaci, radix Angelicae Dahuricae, herba Patriniae, coicis semen, cortex moutan, rhizoma Acori Graminei, rhizoma Belamcandae, radix Platycodi, fructus Arctii and Glycyrrhrizae radix, mixing, grinding into powder, and sieving to obtain Chinese medicinal powder; wherein the sieving is 80-100 mesh sieving.
And filling the traditional Chinese medicine powder into a capsule shell to obtain the capsule.
The decoction is prepared according to the following method:
a) Mixing flos Chrysanthemi Indici, flos Lonicerae, herba Violae, semen Abutili, herba Taraxaci, radix Angelicae Dahuricae, herba Patriniae, coicis semen, cortex moutan, rhizoma Acori Graminei, rhizoma Belamcandae, radix Platycodi, fructus Arctii and Glycyrrhrizae radix with water, and heating and extracting to obtain extract;
b) Performing solid-liquid separation on the extract to obtain medicine residues and an extracting solution;
c) Mixing the medicine residues with water, heating and extracting, and carrying out solid-liquid separation to obtain an extracting solution;
d) Mixing the extractive solution obtained in step B) with the extractive solution obtained in step C) to obtain decoction.
Wherein, in the step A), the mass ratio of the total mass of the traditional Chinese medicines to the water is 1:6. after mixing, the traditional Chinese medicines are firstly soaked for 35 to 45 minutes. And after the soaking is finished, heating the mixture, wherein the heating is carried out by boiling the mixture with strong fire and then heating the mixture with slow fire for 30 to 40 minutes. After heating, cooling the extract, and performing solid-liquid separation to obtain residue and extractive solution.
In the step C), when the medicine residues are mixed with water, the water is hot water with the temperature of 30-50 ℃, and the mass ratio of the medicine residues to the water is 1:3. the heating extraction is to heat for 25 to 35 minutes with slow fire after the mixture is heated and boiled.
Mixing the extractive solution obtained in step B) with the extractive solution obtained in step C) to obtain decoction. Sterilizing the decoction, packaging, sealing, refrigerating, and heating before administration.
The prescription of the invention takes wild chrysanthemum and honeysuckle as monarch drugs, wherein the wild chrysanthemum, ancient name of bitter Job's tears, is pungent, bitter and warm in taste, and is good at treating carbuncle poison scrofula, des concoction materia Medica, and Chinese medicine dictionary carries the functions of dispelling wind and clearing heat, and detumescence and detoxification, and the prescription takes the drastic effect of clearing heat and detoxification; honeysuckle flower is bitter and sweet in taste, neutral in nature, slightly cold in nature, and can treat dysentery due to heat-toxicity, bloody dysentery, carbuncle and toxin, tonify deficiency and cure wind, so it is also the disinfectant in Lei Gong processing Yao Ji, newly compiled materia Medica. All flowers are ascending, and wild chrysanthemum flower and honeysuckle flower have the property of clearing heat and ascending to reach high-position disease centers, have the function of clearing heat and removing toxicity, and are not compatible with other medicines, so the wild chrysanthemum flower and the honeysuckle flower are monarch drugs. The herba violae, the dandelion, the mallow seeds and the moutan bark are ministerial drugs, wherein the herba violae and the dandelion are commonly called as the herba violae, the purple flower is one of the herba violae and the daylily is one of the daylily, and are all used as whole herbs, and the herba violae and the dandelion are pungent and bitter in property, slightly cold in property, functional heat toxin, digestion toxin relieving and swollen stone eliminating, and the herba violae and the daylily are usually mutually reinforced to be used, thereby specially treating the unknown swollen toxin 'Ben Cao Bian', and assisting the monarch drugs to perform the function of detoxification; abelmoschus seeds, sweet in taste and cold in nature, cloud in Ben Cao: mainly refers to the five internal organs and six fu organs, such as cold, heat, emaciation, five urine retention and urination promotion, the term "derivation" means that the Chinese herbal medicine is good at treating carbuncle and furuncle caused by toxic heat attack, and the Chinese herbal medicine is used as a ministerial medicine for assisting the monarch medicine in clearing heat; cortex moutan has the effects of cold qi, bitter and pungent taste, and yin-middle-slight yang, and can purge yin-middle fire, so the formula is called from materia medica to calm five internal organs, treat carbuncle sore and guest heat, and the formula is a ministerial medicine to help the monarch medicine purge blood-middle fire. The angelica dahurica and the rhizoma acori graminei, the patrinia herb and the semen coicis and the blackberry lily and the burdock are adjuvant medicaments, wherein the angelica dahurica and the rhizoma acori graminei are pungent in flavor and warm in nature and are fragrant and scattered, and the cold property of the adjuvant medicaments is assisted, guided and cleared away; the patrinia and coix seeds have the functions of assisting the monarch and minister in purging the heat by applying the method of the lung and the large intestine to the exterior and interior; belamcanda chinensis and great burdock achene are used for treating swollen abscess of throat and assisting monarch and minister to reduce swelling. The platycodon root and the liquorice are guiding drugs, wherein the platycodon root is pungent and slightly warm in flavor, is specially used for treating lung diseases, ascends through lung channels, and directly reaches the disease sites, so that the effects of clearing throat and benefiting diaphragm are achieved. Licorice root, radix Glycyrrhizae has the main action of harmonizing the actions of the other drugs and clearing heat. The traditional Chinese medicine composition has reasonable and balanced configuration, takes effect by the synergy of all raw materials, treats both symptoms and root causes, clears away heat and toxic materials, nourishes yin and moistens dryness, promotes blood circulation and reduces swelling, has no toxic or side effect, and has the advantages of good curative effect, quick response, strong drug effect, difficult relapse and the like in the aspect of treating acute tonsillitis.
For further understanding of the present invention, the following examples are provided to illustrate the traditional Chinese medicine composition for treating acute tonsillitis and the application thereof, and the scope of the present invention is not limited by the following examples.
Example 1
1. The formula is as follows:
the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 10 parts of wild chrysanthemum flower, 10 parts of honeysuckle flower, 10 parts of Chinese violet, 10 parts of malva seed, 10 parts of dandelion, 5 parts of angelica dahurica, 20 parts of dahurian patrinia herb, 20 parts of coix seed, 10 parts of tree peony bark, 8 parts of grassleaf sweelflag rhizome, 4 parts of blackberry lily, 5 parts of platycodon root, 5 parts of great burdock achene and 6 parts of liquorice.
2. Preparation method
Taking the traditional Chinese medicines of the components according to the parts by weight, and putting the traditional Chinese medicines into a marmite; adding the traditional Chinese medicines and water into a marmite according to the mass ratio of 1:6, adding water according to the proportion, and soaking for 45 minutes; boiling with strong fire, heating with slow fire for 30 min, and pouring into a container to obtain a first medicinal liquid; and decocting for the second time by the above method, wherein the mass ratio of the decoction dregs to the water in the second time is 1:3, after boiling, heating with slow fire for about 25 minutes, mixing the two boiled liquid medicines in the same container, sterilizing the prepared liquid medicine, filling, sealing and refrigerating.
Example 2
1. The formula is as follows:
the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 15 parts of wild chrysanthemum flower, 15 parts of honeysuckle flower, 15 parts of Chinese violet, 15 parts of malva seed, 15 parts of dandelion, 10 parts of angelica dahurica, 30 parts of patrinia, 30 parts of coix seed, 15 parts of moutan bark, 10 parts of grassleaf sweelflag rhizome, 6 parts of blackberry lily, 10 parts of platycodon root, 6 parts of great burdock achene and 6 parts of liquorice.
2. Preparation method
Same as example 1
Example 3
1. The formula is as follows:
the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 20 parts of wild chrysanthemum flower, 20 parts of honeysuckle flower, 20 parts of Chinese violet, 20 parts of chingma abutilon seed, 20 parts of dandelion, 15 parts of angelica dahurica, 40 parts of dahurian patrinia herb, 40 parts of coix seed, 20 parts of moutan bark, 16 parts of grassleaf sweelflag rhizome, 8 parts of blackberry lily, 10 parts of platycodon grandiflorum, 9 parts of great burdock achene and 9 parts of liquorice.
2. Preparation method
Same as example 1
Comparative example 1:
an external anti-inflammatory liquid for treating acute tonsillitis and chronic tonsillitis, which comprises the following ingredients by weight: the preparation method comprises the steps of soaking the rhubarb 20%, the dried alum 20%, the salt 15%, the boron matte 15%, the iodine-containing tablets 1.6%, the eupatorium 25% and the balance of 75% alcohol in 75% alcohol solution, fishing out the residues after 1 day, mixing and grinding the rhubarb, the dried alum, the boron matte and the iodine-containing tablets into powder according to a certain proportion, and soaking the powder in the powder for 3 days for later use.
Comparative example 2:
1. the formula is as follows:
a traditional Chinese medicine for treating acute tonsillitis is prepared by decocting raw materials of radix Cyathulae 15 parts, herba Violae Juzemae 20 parts, flos Lonicerae 20 parts, and radix Paeoniae Rubra 15 parts with water.
2. Preparation method
Same as example 1
Comparative example 3:
1. the formula is as follows:
a traditional Chinese medicine composition for treating tonsillitis is prepared from the following raw materials in parts by weight: 15 parts of wild chrysanthemum flower, 8 parts of liquorice, 16 parts of rhizoma anemarrhenae, 18 parts of paederia scandens, 12 parts of honeysuckle, 8 parts of fructus forsythiae, 18 parts of watermelon peel, 12 parts of platycodon grandiflorum, 12 parts of radix scrophulariae, 8 parts of coptis chinensis, 15 parts of common sage herb, 18 parts of radix scutellariae, 12 parts of ficus microcarpa leaves, 16 parts of radix ophiopogonis, 18 parts of radix rehmanniae, 15 parts of rabdosia rubescens, 20 parts of periostracum cicada, 8 parts of radix angelicae, 7 parts of burdock, 15 parts of paulownia flower, 20 parts of roughhaired holly root, 8 parts of blackberry lily, 12 parts of cortex moutan, 9 parts of common andrographis herb and 12 parts of boat-fruited sterculia seed.
2. Preparation method
Same as example 1
Comparative example 4:
removing the chrysanthemum indicum which is a monarch drug, wherein the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 15 parts of honeysuckle, 15 parts of Chinese violet, 15 parts of malva seed, 15 parts of dandelion, 10 parts of angelica dahurica, 30 parts of patrinia, 30 parts of semen coicis, 15 parts of moutan bark, 10 parts of rhizoma acori graminei, 6 parts of blackberrykiky rhizome, 10 parts of platycodon grandiflorum, 6 parts of burdock and 6 parts of liquorice.
2. Preparation method
Same as example 1
Example 4 toxicity test
20 adult female mice and adult male mice with the same body weight are selected respectively and divided into a control group and an administration group, the administration group is divided into 3 groups, 3 groups are respectively 3 in example 1 and example 3, 4 groups in example 2, the raising conditions are consistent, the control group is not fed with drugs, the administration group is respectively fed with the drugs prepared in example 1, example 2 and example 3, the administration group is fed with the drugs 1 time per day, the dose is the normal dose of adults and is converted into the dose of the mice, the physical condition, the food intake, the water intake and the body weight of each mouse are recorded per day, the test lasts for six months, and compared with the control group, the body condition, the food intake, the water intake and the body weight increase of the administration group are normal, and the mice are not sick or dead. The medicine powder has good safety and no toxic or side effect.
Example 5 safety evaluation
Monitoring the adverse reaction condition of the patient in the medication process, and immediately stopping the medication process if more than three serious adverse reactions occur.
According to observation, 700 patients have no serious adverse reaction event during the administration period, and the incidence rate of the tertiary adverse reaction of each group is 0 when 100 patients are respectively selected from the group consisting of example 1, example 2, example 3, comparative example 1, comparative example 2, comparative example 3 and comparative example 4. The statistical results are shown in the following table.
TABLE 1 evaluation of safety
Figure BDA0003809669410000101
Example 6
The invention is further illustrated below in connection with clinical trials conducted at the first subsidiary hospital of the university of traditional Chinese medicine in Henan:
1. case selection: the selected cases are acute tonsillitis patients in the first affiliated hospital of Henan university of traditional Chinese medicine, 700 acute tonsillitis patients are selected, and 100 patients in each group of example 1, example 2, example 3, comparative example 1, comparative example 2, comparative example 3 and comparative example 4 have the course of disease of 1 day to 6 months; graduation of tonsil enlargement: degree I: beyond the palatoglossal arch, but not the palatopharyngeal arch; II degree: beyond the palatopharyngeal arch, short of the posterior pharyngeal midline; and (3) III degree: up to or beyond the posterior pharyngeal wall midline. The specific grouping is as follows:
example 1 groups 44 men and 56 women; 21 cases of acute catarrhal tonsillitis, 79 cases of acute suppurative tonsillitis; tonsil with 41 cases of I-degree enlargement, 33 cases of II-degree enlargement and 26 cases of III-degree enlargement;
example 2 groups 40 men and 60 women; 23 cases of acute catarrhal tonsillitis, 77 cases of acute suppurative tonsillitis; 42 cases of tonsil swelling with I degree, 31 cases of swelling with II degree and 27 cases of swelling with III degree;
example 3 groups 45 men and 55 women; 22 cases of acute catarrhal tonsillitis, 78 cases of acute suppurative tonsillitis; tonsil with 45 cases of I-degree enlargement, 34 cases of II-degree enlargement and 21 cases of III-degree enlargement;
comparative example 1 group 42 men and 58 women; 20 cases of acute catarrhal tonsillitis and 80 cases of acute suppurative tonsillitis; 43 cases of tonsil swelling at I degree, 35 cases of swelling at II degree and 22 cases of swelling at III degree;
comparative example 2 groups 41 men and 59 women; 25 cases of acute catarrhal tonsillitis and 75 cases of acute suppurative tonsillitis; 47 cases of tonsil with I-degree enlargement, 32 cases of II-degree enlargement and 21 cases of III-degree enlargement;
comparative example 3 groups 43 men and 57 women; 24 cases of acute catarrhal tonsillitis, 76 cases of acute suppurative tonsillitis; tonsil with 45 cases of I-degree enlargement, 32 cases of II-degree enlargement and 23 cases of III-degree enlargement;
comparative example 4 groups 46 men and 54 women; 26 cases of acute catarrhal tonsillitis, 74 cases of acute suppurative tonsillitis; tonsil with swelling degree I46 cases, II with swelling degree 31 cases, III with swelling degree 23 cases.
2. Diagnostic criteria: according to the national administration of traditional Chinese medicine, the standard of curative effect of the diagnosis of the traditional Chinese medicine diseases, the diagnosis is confirmed according to the symptoms, physical signs, the total number of leucocytes and the neutrophil count of a patient.
3. The treatment method comprises the following steps: the medicine is taken according to the following taking method in the embodiments 1-3 and the comparative examples 2-4 every day, 1 dose is taken orally every time, three times a day, 7 days are taken as a course of treatment, 2 courses of treatment are generally continuously taken until the signs of clinical symptoms disappear, the curative effect is consolidated, the medicine is taken for 1 course of treatment, and the medicine is taken after a visit for 3 months. During the treatment period, patients are advised to eat easily digestible nutrient-rich semifluid or soft food and fast spicy, greasy and hard stimulating food.
Comparative example 1 was used as follows:
when in use, the anti-inflammatory liquid is smeared on the tonsil of a patient under the guidance of a doctor, and the treatment is carried out 2 times a day. During operation, adopt the liquid medicine fixed point external application treatment, can be earlier with the wet compress of the big cotton ball of vascular pincers centre gripping prefabricated broad bean in reserve anti-inflammatory liquid bottle, take the bottleneck and force to remove unnecessary liquid medicine, order the patient to enlarge the oral cavity, press tongue 1/2 with the duck tongue board that has disinfected on one hand and make the almond physical stamina clearly see, the other hand is about to go deep into patient's oral cavity with the absorbent cotton that has prepared on the vascular pincers, wet compress fast on its tonsil, then take out vascular pincers absorbent cotton and tongue depressor fast, accomplish within 3 seconds generally and be suitable. After 10 minutes, the operation is repeated, and the treatment is finished.
The medicine is used for 7 days as a treatment course, is generally continuously used for 2 treatment courses until clinical symptoms and signs disappear, is used for 1 treatment course after the curative effect is consolidated, and is followed for 3 months. During the treatment period, patients are advised to eat easily digestible and nutrient-rich semifluid or soft food and fast spicy, greasy and hard irritative food.
4. The evaluation standard of the curative effect is as follows:
and (3) curing: pharyngeal symptoms disappear, tonsils are not congested, pus points do not exist, or the pharynx is removed. The blood is normally and completely recovered, and the total number of leucocytes is reduced to 10.0 x 10 by laboratory examination 9 Less than L, the number of neutrophils decreases to 7.0X 10 9 below/L, no recurrence was observed for 6 months of follow-up.
Improvement: the pharyngeal symptom is relieved, the suppurative point of tonsil is eliminated, and the body temperature is close to normal. The blood routine is close to normal, and the total number of white blood cells is reduced to 10.0 x 10 in laboratory examination 9 Less than L, the number of neutrophils decreases to 7.0X 10 9 The disease is stable and has no recurrence after 3 months of follow-up visit.
The disease is not cured: there was no significant improvement in symptoms and signs. Blood routine has no obvious change, and laboratory examination of total leucocyte and neutrophil has no obvious progress.
5. The observation indexes of the curative effect are as follows:
total score of symptoms: according to the main symptom scoring table, common symptoms of the patients, such as fever, pharyngalgia, tonsil swelling and tonsil suppuration, are observed and inquired, and the total score is recorded in detail, wherein the total score is the sum of the symptom scores of the patients, and the higher the score is, the more serious the symptom is.
6. The treatment effect is as follows: the traditional Chinese medicine compositions are applied to 100 clinical cases of patients with acute tonsillitis for 2 courses of treatment, and after clinical symptom signs disappear, the traditional Chinese medicine compositions are consolidated in curative effect and taken for 1 course of treatment, and the curative effect evaluation criteria are applied to evaluate the curative effect: 73 cases are cured, and the cure rate is about 73%; 22 cases of improvement, accounting for about 22%; the disease is not cured for 5 cases, and accounts for about 5 percent. The total effective rate is about 95%. The therapeutic effects are shown in tables 2 and 3.
6.1 comparison of clinical efficacy
As shown in table 2, the clinical effective rates of inventive examples 1 to 3 were 91%, 95% and 92%, which are significantly higher than those of comparative example group.
TABLE 2 comparison of the clinical efficacy of the groups after treatment
Figure BDA0003809669410000121
6.2 Total score comparison of symptoms
As shown in Table 3, inventive examples 1-3 were able to reduce the total score of symptoms, the difference being statistically significant, compared to pre-treatment and examples and comparative examples.
TABLE 3 Total score comparison of symptoms in each group before and after treatment
Figure BDA0003809669410000122
Figure BDA0003809669410000131
Note: p < 0.05 in group compared to pre-treatment.
7. And (3) safety evaluation: by revisiting, during the period of taking the medicine, the patients taking the preparations of the embodiment and the comparative example have no side effects such as anorexia, dizziness, nausea, pruritus, diarrhea and the like, only 1 patient has slight vomiting, and the other patients have no obvious vomiting. When the relapse condition of the patient after the withdrawal of the drug is tracked and investigated, the result shows that the patient who takes the preparation of the embodiment of the invention has no recurrent episodes of acute tonsillitis within one year, and the statistical result is shown in table 4. In conclusion, the preparation has the advantages of quick response, strong drug effect, difficult relapse and no toxic or side effect.
TABLE 4 number of adverse reactions occurring during dosing and relapse within one year after drug withdrawal
Figure BDA0003809669410000132
Figure BDA0003809669410000141
Note: relapse rate = (number of relapses)/(total number) х% 100%
Example 7 typical cases
Case 1: old certain, woman, age 38. Xu Jiuzhen at 21 st 4/1/2019: high fever (39.7 ℃), cough, hemoptysis, sore throat, dry lips, aphonia, general muscle pain, dark urine, dry stool, deep-red tongue, thin white fur, and superficial and rapid pulse. Physical examination: the tonsils on both sides are swollen at an I degree, scattered at the suppurative site, and the auscultation of both lungs is not abnormal; auxiliary inspection: the blood routine indicates that the total number of the white blood cells and the neutrophils are increased, and the white blood cells are 35.39 multiplied by 10 9 L, neutrophil 15.4X 10 9 And L, no obvious abnormality is found in chest CT. And (3) Western diagnosis: acute suppurative tonsillitis; traditional Chinese medicine diagnosis: acute tonsillitis (syndrome of wind-heat invasion); therapeutic principle: clearing away heat and toxic material, relieving sore-throat and eliminating swelling.
The traditional Chinese medicine decoction provided in embodiment 1 is taken. The taking method comprises the following steps: decocting with water, taking 1 dose each time, taking three times a day, taking 7 days as a course of treatment, continuously taking 2 courses, wherein the body temperature fluctuation is 37.5-39.3 ℃ in the early treatment period, the body temperature is normal after 1 day, no fever occurs, the whole body is light, fast and painless, a patient can speak normally, the tone is slightly deep, the pharyngalgia is obviously relieved, no hemoptysis occurs, the patient still has cough and sticky phlegm, dry throat and dry stool, the tongue is dark red, thin white and greasy fur, and the pulse is micro-rapid. After 2 treatment courses, no pus spots were found. The blood was checked again and there was no abnormality. The disease does not relapse after half a year of follow-up.
Case 2: zhu somebody, man, 59 years old. The sore throat after the cold in 2019 in 8 and 1 month appears, the symptoms of the cold are not obvious, poor appetite, dry and hard stool, red tongue, yellow and greasy coating, and floating and slippery pulse, which are not regarded and treated, the symptoms are not obviously improved, and the sore throat is aggravated in 2019 in 8 and 9 months, so that the first affiliated hospital of the Henan university of traditional Chinese medicine is called for further diagnosis and treatment. Physical examination: the body temperature is 39.6 ℃, the pharynx is congested (+ +), the left tonsil is swollen at II degrees, congestion is caused, a plurality of pus spots are visible and are connected into slices, the right tonsil is swollen at I degrees, the color is red, and no pus spot is temporarily seen; auxiliary inspection: the blood routine indicates that the total number of the white blood cells and the neutrophils are increased, and the white blood cells are 36.6 multiplied by 10 9 L, 18.6X 10 neutrophils 9 the/L, X-ray shows that both lungs are normal. And (3) Western diagnosis: acute suppurative tonsillitis; traditional Chinese medicine diagnosis: acute tonsillitis(syndrome of wind-heat invading the exterior); therapeutic principle: clearing away heat and toxic material, relieving sore-throat and eliminating swelling.
The traditional Chinese medicine decoction provided in example 2 is taken. The taking method comprises the following steps: the medicine is decocted in water for oral administration, 1 dose is taken orally each time, three times a day, 7 days are taken as a treatment course, and the medicine is cured after continuously taking for 2 treatment courses. The disease does not relapse after half a year of follow-up.
Case 3: a doctor in Tang Dynasty, male, 20 years old, is diagnosed at 21 days 7 and 7 months in 2019 mainly because of repeated pharyngalgia with low fever, has no obvious inducement to pharyngalgia, fever, 38.0 ℃ of maximum body temperature, nasal obstruction, running nose, cough, expectoration, obvious foreign body sensation, obvious snore, suffocation, joint pain and other discomfort before half year, and has no throat pain after the local clinic presses the cold for static dripping (the medicine is not detailed). The low heat is continuously generated in the last half year, and the temperature fluctuates between 37.1 and 37.3 ℃, which is not taken into consideration. The discomfort of the pharynx was obvious in 7 months and 21 days in 2019, and the method is a first subsidiary hospital of Henan university of traditional Chinese medicine for Chinese medicine treatment. Auxiliary inspection: the blood routine indicates that the total number of leukocytes and neutrophils are increased, and the leukocytes are 25.0 multiplied by 10 9 L, neutrophil 13.7X 10 9 And L. And (3) Western diagnosis: acute suppurative tonsillitis; traditional Chinese medicine diagnosis: acute tonsillitis (syndrome of wind-heat invasion); the therapeutic principle is as follows: clearing away heat and toxic material, relieving sore-throat and eliminating swelling.
The Chinese medicinal decoction provided in example 3 is taken. The taking method comprises the following steps: the medicine is decocted in water for oral administration, 1 dose is taken orally each time, three times a day, 7 days are taken as a treatment course, and the medicine is cured after continuously taking for 2 treatment courses. The disease condition is stable and does not relapse after half a year of follow-up visit.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims (9)

1. A traditional Chinese medicine composition for treating acute tonsillitis is characterized by comprising the following raw materials in parts by weight: 10-20 parts of wild chrysanthemum flower, 10-20 parts of honeysuckle flower, 10-20 parts of Chinese violet, 10-20 parts of chingma abutilon seed, 10-20 parts of dandelion, 5-15 parts of angelica dahurica, 20-40 parts of herba patriniae, 20-40 parts of coix seed, 10-20 parts of moutan bark, 8-16 parts of rhizoma acori graminei, 4-8 parts of blackberry lily, 5-10 parts of platycodon grandiflorum, 5-9 parts of burdock fruit and 5-9 parts of liquorice.
2. The traditional Chinese medicine composition according to claim 1, which comprises the following raw materials in parts by weight:
10 parts of wild chrysanthemum flower, 10 parts of honeysuckle flower, 10 parts of Chinese violet, 10 parts of cluster mallow fruit, 10 parts of dandelion, 5 parts of angelica dahurica, 20 parts of dahurian patrinia herb, 20 parts of coix seed, 10 parts of tree peony bark, 8 parts of grassleaf sweelflag rhizome, 4 parts of blackberry lily, 5 parts of platycodon root, 5 parts of great burdock achene and 6 parts of liquorice.
3. The traditional Chinese medicine composition according to claim 1, which comprises the following raw materials in parts by weight:
15 parts of wild chrysanthemum flower, 15 parts of honeysuckle flower, 15 parts of Chinese violet, 15 parts of malva seed, 15 parts of dandelion, 10 parts of angelica dahurica, 30 parts of patrinia, 30 parts of coix seed, 15 parts of moutan bark, 10 parts of grassleaf sweelflag rhizome, 6 parts of blackberry lily, 10 parts of platycodon root, 6 parts of great burdock achene and 6 parts of liquorice.
4. The traditional Chinese medicine composition according to claim 1, which comprises the following raw materials in parts by weight:
20 parts of wild chrysanthemum flower, 20 parts of honeysuckle flower, 20 parts of Chinese violet, 20 parts of chingma abutilon seed, 20 parts of dandelion, 15 parts of angelica dahurica, 40 parts of dahurian patrinia herb, 40 parts of coix seed, 20 parts of moutan bark, 16 parts of grassleaf sweelflag rhizome, 8 parts of blackberry lily, 10 parts of platycodon grandiflorum, 9 parts of great burdock achene and 9 parts of liquorice.
5. Use of the Chinese medicinal composition of any one of claims 1-4 in the preparation of a medicament for the treatment and/or prevention of acute tonsillitis.
6. Use according to claim 5, wherein the medicament is selected from a powder, capsule or decoction.
7. Use according to claim 6, characterized in that the powder is prepared according to the following method:
respectively drying flos Chrysanthemi Indici, flos Lonicerae, herba Violae, semen Abutili, herba Taraxaci, radix Angelicae Dahuricae, herba Patriniae, coicis semen, cortex moutan, rhizoma Acori Graminei, rhizoma Belamcandae, radix Platycodi, fructus Arctii and Glycyrrhrizae radix, mixing, grinding into powder, and sieving to obtain Chinese medicinal powder.
8. Use according to claim 6, wherein the capsules are prepared according to the following method:
respectively drying flos Chrysanthemi Indici, flos Lonicerae, herba Violae, semen Abutili, herba Taraxaci, radix Angelicae Dahuricae, herba Patriniae, coicis semen, cortex moutan, rhizoma Acori Graminei, rhizoma Belamcandae, radix Platycodi, fructus Arctii and Glycyrrhrizae radix, mixing, grinding into powder, and sieving to obtain Chinese medicinal powder;
and filling the traditional Chinese medicine powder into a capsule shell to obtain the capsule.
9. The use of claim 6, wherein the decoction is prepared as follows:
a) Mixing flos Chrysanthemi Indici, flos Lonicerae, herba Violae, semen Abutili, herba Taraxaci, radix Angelicae Dahuricae, herba Patriniae, coicis semen, cortex moutan, rhizoma Acori Graminei, rhizoma Belamcandae, radix Platycodi, fructus Arctii and Glycyrrhrizae radix with water, and heating and extracting to obtain extract;
b) Performing solid-liquid separation on the extract to obtain medicine residues and an extracting solution;
c) Mixing the medicine residues with water, heating and extracting, and carrying out solid-liquid separation to obtain an extracting solution;
d) Mixing the extractive solution obtained in step B) with the extractive solution obtained in step C) to obtain decoction.
CN202211007905.2A 2022-08-22 2022-08-22 Traditional Chinese medicine composition for treating acute tonsillitis and application thereof Withdrawn CN115227787A (en)

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