CN115227767A - 一种治疗高尿酸血症及降低尿酸的中药 - Google Patents
一种治疗高尿酸血症及降低尿酸的中药 Download PDFInfo
- Publication number
- CN115227767A CN115227767A CN202210929075.2A CN202210929075A CN115227767A CN 115227767 A CN115227767 A CN 115227767A CN 202210929075 A CN202210929075 A CN 202210929075A CN 115227767 A CN115227767 A CN 115227767A
- Authority
- CN
- China
- Prior art keywords
- parts
- pills
- uric acid
- traditional chinese
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 title claims abstract description 30
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 title claims abstract description 30
- 229940116269 uric acid Drugs 0.000 title claims abstract description 30
- 201000001431 Hyperuricemia Diseases 0.000 title claims abstract description 25
- 239000003814 drug Substances 0.000 title claims abstract description 20
- 239000006187 pill Substances 0.000 claims abstract description 36
- 235000012907 honey Nutrition 0.000 claims abstract description 25
- 239000000853 adhesive Substances 0.000 claims abstract description 17
- 230000001070 adhesive effect Effects 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 239000000463 material Substances 0.000 claims abstract description 9
- 241000382455 Angelica sinensis Species 0.000 claims abstract description 4
- 241000758794 Asarum Species 0.000 claims abstract description 4
- 241000045403 Astragalus propinquus Species 0.000 claims abstract description 4
- 241000132012 Atractylodes Species 0.000 claims abstract description 4
- 244000223760 Cinnamomum zeylanicum Species 0.000 claims abstract description 4
- 241000112528 Ligusticum striatum Species 0.000 claims abstract description 4
- 244000131316 Panax pseudoginseng Species 0.000 claims abstract description 4
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 4
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 4
- 244000197580 Poria cocos Species 0.000 claims abstract description 4
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 4
- 241000009298 Trigla lyra Species 0.000 claims abstract description 4
- 244000126002 Ziziphus vulgaris Species 0.000 claims abstract description 4
- 235000006533 astragalus Nutrition 0.000 claims abstract description 4
- 235000007215 black sesame Nutrition 0.000 claims abstract description 4
- 235000017803 cinnamon Nutrition 0.000 claims abstract description 4
- 235000008434 ginseng Nutrition 0.000 claims abstract description 4
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 4
- 210000000582 semen Anatomy 0.000 claims abstract description 3
- 241000173529 Aconitum napellus Species 0.000 claims abstract 2
- 238000001035 drying Methods 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 14
- 238000009835 boiling Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 239000011248 coating agent Substances 0.000 claims description 9
- 238000000576 coating method Methods 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 9
- 239000000314 lubricant Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 4
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 claims description 3
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 claims description 3
- 244000068988 Glycine max Species 0.000 claims description 3
- 235000010469 Glycine max Nutrition 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000007667 floating Methods 0.000 claims description 3
- 239000006260 foam Substances 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000004898 kneading Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 238000007670 refining Methods 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- 239000011230 binding agent Substances 0.000 claims description 2
- 239000008159 sesame oil Substances 0.000 claims description 2
- 235000011803 sesame oil Nutrition 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
- 210000002700 urine Anatomy 0.000 abstract description 12
- 210000002966 serum Anatomy 0.000 abstract description 8
- 210000004369 blood Anatomy 0.000 abstract description 7
- 239000008280 blood Substances 0.000 abstract description 7
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract description 6
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 5
- 201000005569 Gout Diseases 0.000 abstract description 4
- 230000000052 comparative effect Effects 0.000 description 15
- 230000029142 excretion Effects 0.000 description 3
- 150000003626 triacylglycerols Chemical class 0.000 description 3
- 241000227129 Aconitum Species 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000009982 effect on human Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 230000004144 purine metabolism Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/288—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及中药技术领域，公开了一种治疗高尿酸血症及降低尿酸的中药，包括原料和辅料，所述原料的组分由以下重量份组成：50份黄芪、15份白芍、15份白术、15份毕解、15份肉桂、15份独活、15份人参、15份半下、15份当归、15份云苓、15份防风10、8份川芎、15份附子、15份羌活、15份云羊合、15份枣仁、10份炙草、10份细辛、15份收山虎、15份闰王刺、15份鸟不站、15份冬桑叶和15份黑芝麻，所述辅料由粘合剂和蜜水组成。本发明通过多种纯中药制备成药丸，可以有效地降低高尿酸症患者的血尿酸含量，同时可以增加患者的尿尿酸和尿pH值，并降低血清胆周醇和甘油三酯的含量，彻底治愈患者的高尿酸血症，减少痛风的发作。
Description
技术领域
本发明涉及中药技术领域，具体是一种治疗高尿酸血症及降低尿酸的中药。
背景技术
尿酸是人类嘌呤代谢的终产物,主要经过肾脏***，随着物质生活水平的提高，人们的饮食结构发生改变，长期高嘌吟饮食使高尿酸血症和痛风的发生率逐年增长，长期高尿酸血症易诱发痛风,还容易累及肾脏和心血管***，由于中药在治疗高尿酸症具有用药安全、有效、副作用小，而广泛使用。
中国专利公开了一种治疗高尿酸血症的中药(公告号CN105687901A)，该专利技术选择的药材为纯中药制剂，对身体无副作用，并且治疗高尿酸血症效果好，治疗周期短，但是其不能有效地提高尿尿酸的***和尿pH值，并不能有效地降低血清胆周醇和甘油三酯的含量。
发明内容
本发明的目的在于提供一种治疗高尿酸血症及降低尿酸的中药，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供如下技术方案：
一种治疗高尿酸血症及降低尿酸的中药，包括原料和辅料，所述原料的组分由以下重量份组成：50份黄芪、15份白芍、15份白术、15份毕解、15份肉桂、15份独活、15份人参、15份半下、15份当归、15份云苓、15份防风10、8份川芎、15份附子、15份羌活、15份云羊合、15份枣仁、10份炙草、10份细辛、15份收山虎、15份闰王刺、15份鸟不站、15份冬桑叶和15份黑芝麻，所述辅料由粘合剂和蜜水组成。
作为本发明再进一步的方案：其制备工艺包括以下步骤：
S1、药粉制备：将各原料分别进行清洗，再将清洗干净后的原料分别烘干、粉碎、研磨，过100目筛，将过筛后的药粉经钴-60辐照灭菌，然后将各原料粉按照比例混合，制得药粉；
S2、粘合剂和蜜水制备：取质量份10份纯水煮沸，加入30份炼蜜，同时搅拌至全部溶化，再次煮沸、过滤即可，制得粘合剂；再将10份煮沸纯水与10份炼蜜混合溶化、煮沸、过滤，制得蜜水；
S3、湿药丸制备：在搅拌釜内涂抹一层润滑剂，向搅拌釜内不断加入药粉和粘合剂，并不断搅拌，等结成团块、色泽一直后，再进行揉捏搓条，再通过模具制成黄豆粒大小的湿药丸；
S4、包衣成丸：将湿药丸放入到热风循环箱内干燥，再将干燥后的药丸放入到包衣锅内，在包衣锅转动的过程中，向药丸喷洒蜜水，使药丸湿润均匀，在转动的过程中，使药丸互相摩擦，表面光亮；
S5、消毒包装：打光后的药丸再次放入到热风循环箱内干燥，再通过微波灭菌消毒后，包装分袋，每袋5g，服用方法为每日三次温服，每次一袋。
作为本发明再进一步的方案：所述S2步骤中炼蜜的方法包括以下步骤：
将蜂蜜过滤后，加入到蒸煮锅中加热沸腾，然后除去泡沫和上浮蜡质，当呈现出金黄色至黄棕色稠厚糖浆状液体，手捻有粘性，两手指分开无长白丝出现，迅速出锅，自然冷却，即得到炼蜜。
作为本发明再进一步的方案：所述S3步骤中药粉和粘合剂的质量比为1:0.8～0.9，且S3步骤中润滑剂为甘油或麻油。
作为本发明再进一步的方案：所述S4步骤中湿药丸的干燥温度为55±2℃，湿药丸干燥后水分≤7％。
作为本发明再进一步的方案：所述S5步骤中药丸的干燥温度为60±2℃，干燥时间为180～240℃。
与现有技术相比，本发明的有益效果：
本发明通过多种纯中药制备成药丸，可以有效地降低高尿酸症患者的血尿酸含量，同时可以增加患者的尿尿酸的***，提高尿pH值，并降低血清胆周醇和甘油三酯的含量，彻底治愈患者的高尿酸血症，减少痛风的发作。
具体实施方式
本发明实施例中，一种治疗高尿酸血症及降低尿酸的中药，包括原料和辅料，原料的组分由以下重量份组成：50份黄芪、15份白芍、15份白术、15份毕解、15份肉桂、15份独活、15份人参、15份半下、15份当归、15份云苓、15份防风10、8份川芎、15份附子、15份羌活、15份云羊合、15份枣仁、10份炙草、10份细辛、15份收山虎、15份闰王刺、15份鸟不站、15份冬桑叶和15份黑芝麻，辅料由粘合剂和蜜水组成。
优选的，其制备工艺包括以下步骤：
S1、药粉制备：将各原料分别进行清洗，以去除泥土、杂质，再将清洗干净后的原料分别烘干、粉碎、研磨，过100目筛，将过筛后的药粉经钴-60辐照灭菌，然后将各原料粉按照比例混合，制得药粉；
S2、粘合剂和蜜水制备：取质量份10份纯水煮沸，加入30份炼蜜，同时搅拌至全部溶化，再次煮沸、过滤即可，制得粘合剂；再将10份煮沸纯水与10份炼蜜混合溶化、煮沸、过滤，制得蜜水；
S3、湿药丸制备：在搅拌釜内涂抹一层润滑剂，向搅拌釜内不断加入药粉和粘合剂，并不断搅拌，等结成团块、色泽一直后，再进行揉捏搓条，再通过模具制成黄豆粒大小的湿药丸；
S4、包衣成丸：将湿药丸放入到热风循环箱内干燥，再将干燥后的药丸放入到包衣锅内，在包衣锅转动的过程中，向药丸喷洒蜜水，使药丸湿润均匀，在转动的过程中，使药丸互相摩擦，表面光亮；
S5、消毒包装：打光后的药丸再次放入到热风循环箱内干燥，再通过微波灭菌消毒后，包装分袋，每袋5g，服用方法为每日三次温服，每次一袋。
优选的，S2步骤中炼蜜的方法包括以下步骤：
将蜂蜜过滤后，加入到蒸煮锅中加热沸腾，然后除去泡沫和上浮蜡质，当呈现出金黄色至黄棕色稠厚糖浆状液体，手捻有粘性，两手指分开无长白丝出现，迅速出锅，自然冷却，即得到炼蜜。
优选的，S3步骤中药粉和粘合剂的质量比为1:0.8～0.9，且S3步骤中润滑剂为甘油或麻油，通过润滑剂防止粘连早搅拌釜的内壁和搅拌轴上。
优选的，S4步骤中湿药丸的干燥温度为55±2℃，湿药丸干燥后水分≤7％。
优选的，S5步骤中药丸的干燥温度为60±2℃，干燥时间为180～240℃。
为了更好地说明本发明的技术效果，通过下述实施例进行阐述：
选用本发明制备的中药作为实施例；选用专利网公开的用于治疗痛风及高尿酸血症的中药(公开日：2016-10-12，公开号：CN105998453A)制备的中药作为对比例一，选用专利网公开的一种治疗高尿酸血症的中药(公开日：2016-06-22，公开号：CN105687901A)制备的中药作为对比例二
选取因高尿酸血症入院的患者200例，其中，男性和女性各100例，年龄35～75岁，平均年龄(52.43±14.84)岁，病程1～13年，将200例患者随机分成四组，每组均50例，实施例组、对比例一组、对比例二组和对照组，四组患者的基线资料对比，差异无统计学意义(P＞0.05)，数据采用SPSS14.0统计学软件进行分析，以平均值±标准差对计量数据表示，计量资料采用t检验，计数资料采用X2检验，P＜0.05为有统计学意义；
其中，实施例组、对比例一组、对比例二组分别服用实施例、对比例一和对比例二制备的中药，对照组服用安慰剂；在用药前和用药1个月后，分别测量每组中每例患者的血尿酸(单位：μmol/L)、尿尿酸(单位：mmol/L)、尿pH值、血清胆周醇(单位：mmol/L)和甘油三酯(单位：mmol/L)，并计算每组中患者的各项指标的平均值±标准差；并记录到下表1中；
表1血尿酸、尿尿酸、尿pH值、血清胆周醇和甘油三酯的含量
从上表1可以得出：实施例组、对比例一组、对比例二组中的患者血尿酸含量均较大幅度的下降，尿尿酸和尿pH值均较大幅度的增加，血清胆周醇和甘油三酯均较大幅度的降低，具有统计学意义，而对照组中血尿酸、尿尿酸、尿pH值、血清胆周醇和甘油三酯均变化不大，无统计学意义；
同时，实施例组中的患者血尿酸含量下降值大于对比例一组、对比例二组中的患者血尿酸，实施例组中的患者尿尿酸和尿pH值增加值大于对比例一组、对比例二组中的患者尿尿酸和尿pH值增加值，实施例组中的患者血清胆周醇和甘油三酯下降值大于对比例一组、对比例二组中的患者血清胆周醇和甘油三酯下降值。
进而可以得出：本发明制备的中药可以有效地降低高尿酸症患者的血尿酸含量，同时可以增加患者的尿尿酸和尿pH值，从而说明可以提高尿尿酸的***，提高尿pH值，降低血清胆周醇和甘油三酯的含量。
以上所述的，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。
Claims (6)
1.一种治疗高尿酸血症及降低尿酸的中药，包括原料和辅料，其特征在于，所述原料的组分由以下重量份组成：50份黄芪、15份白芍、15份白术、15份毕解、15份肉桂、15份独活、15份人参、15份半下、15份当归、15份云苓、15份防风10、8份川芎、15份附子、15份羌活、15份云羊合、15份枣仁、10份炙草、10份细辛、15份收山虎、15份闰王刺、15份鸟不站、15份冬桑叶和15份黑芝麻，所述辅料由粘合剂和蜜水组成。
2.根据权利要求1所述的一种治疗高尿酸血症及降低尿酸的中药，其特征在于，其制备工艺包括以下步骤：
S1、药粉制备：将各原料分别进行清洗，再将清洗干净后的原料分别烘干、粉碎、研磨，过100目筛，将过筛后的药粉经钴-60辐照灭菌，然后将各原料粉按照比例混合，制得药粉；
S2、粘合剂和蜜水制备：取质量份10份纯水煮沸，加入30份炼蜜，同时搅拌至全部溶化，再次煮沸、过滤即可，制得粘合剂；再将10份煮沸纯水与10份炼蜜混合溶化、煮沸、过滤，制得蜜水；
S3、湿药丸制备：在搅拌釜内涂抹一层润滑剂，向搅拌釜内不断加入药粉和粘合剂，并不断搅拌，等结成团块、色泽一直后，再进行揉捏搓条，再通过模具制成黄豆粒大小的湿药丸；
S4、包衣成丸：将湿药丸放入到热风循环箱内干燥，再将干燥后的药丸放入到包衣锅内，在包衣锅转动的过程中，向药丸喷洒蜜水，使药丸湿润均匀，在转动的过程中，使药丸互相摩擦，表面光亮；
S5、消毒包装：打光后的药丸再次放入到热风循环箱内干燥，再通过微波灭菌消毒后，包装分袋，每袋5g，服用方法为每日三次温服，每次一袋。
3.根据权利要求2所述的一种治疗高尿酸血症及降低尿酸的中药，其特征在于，所述S2步骤中炼蜜的方法包括以下步骤：
将蜂蜜过滤后，加入到蒸煮锅中加热沸腾，然后除去泡沫和上浮蜡质，当呈现出金黄色至黄棕色稠厚糖浆状液体，手捻有粘性，两手指分开无长白丝出现，迅速出锅，自然冷却，即得到炼蜜。
4.根据权利要求2所述的一种治疗高尿酸血症及降低尿酸的中药，其特征在于，所述S3步骤中药粉和粘合剂的质量比为1:0.8～0.9，且S3步骤中润滑剂为甘油或麻油。
5.根据权利要求2所述的一种治疗高尿酸血症及降低尿酸的中药，其特征在于，所述S4步骤中湿药丸的干燥温度为55±2℃，湿药丸干燥后水分≤7%。
6.根据权利要求2所述的一种治疗高尿酸血症及降低尿酸的中药，其特征在于，所述S5步骤中药丸的干燥温度为60±2℃，干燥时间为180～240℃。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210929075.2A CN115227767A (zh) | 2022-08-03 | 2022-08-03 | 一种治疗高尿酸血症及降低尿酸的中药 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210929075.2A CN115227767A (zh) | 2022-08-03 | 2022-08-03 | 一种治疗高尿酸血症及降低尿酸的中药 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115227767A true CN115227767A (zh) | 2022-10-25 |
Family
ID=83677169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210929075.2A Pending CN115227767A (zh) | 2022-08-03 | 2022-08-03 | 一种治疗高尿酸血症及降低尿酸的中药 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115227767A (zh) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101601786A (zh) * | 2008-06-12 | 2009-12-16 | 孙承宽 | 速祛痛风病药剂的制造方法 |
| CN108079162A (zh) * | 2016-11-23 | 2018-05-29 | 刘明明 | 一种治疗痛风的中药配方 |
-
2022
- 2022-08-03 CN CN202210929075.2A patent/CN115227767A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101601786A (zh) * | 2008-06-12 | 2009-12-16 | 孙承宽 | 速祛痛风病药剂的制造方法 |
| CN108079162A (zh) * | 2016-11-23 | 2018-05-29 | 刘明明 | 一种治疗痛风的中药配方 |
Non-Patent Citations (1)
| Title |
|---|
| 高佳麟;戚淑云;: "中西医结合治疗原发性痛风", 医药论坛杂志 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1043010C (zh) | 祛斑美容制剂 | |
| CN1586544A (zh) | 一种药酒及其制造方法 | |
| CN102579667B (zh) | 一种阿归养血颗粒的制备方法 | |
| CN1245707A (zh) | 一种治疗艾滋病及癌症的药物 | |
| CN108042766A (zh) | 一种补肾通络养脑膏及其制备方法 | |
| CN112546148A (zh) | 一种治疗慢性心衰的中药配方及其制备方法 | |
| CN112717068B (zh) | 一种治疗慢性疲劳综合征的中药组合物及其应用 | |
| CN115227767A (zh) | 一种治疗高尿酸血症及降低尿酸的中药 | |
| CN106310042A (zh) | 用中药药渣制备的药石及其制备方法 | |
| CN100457151C (zh) | 黄连上清软胶囊剂及其制备工艺 | |
| CN111632134A (zh) | 一种乌鸡白凤软胶囊及其制备方法和应用 | |
| CN101317924A (zh) | 一种温补脾肾胶囊的制作方法 | |
| CN1709481A (zh) | 一种治疗肾病、***的中药制剂及其制备方法 | |
| CN101317951A (zh) | 一种滋阴清热补心安神胶囊的制作方法 | |
| CN108578480A (zh) | 一种具有健胃止咳功能的胖血藤中药茶的制备工艺 | |
| CN111803576A (zh) | 一种治疗痛风的复方六月雪胶囊 | |
| CN114533803B (zh) | 用于预防老年痴呆的中药组合物及其制备方法 | |
| CN115040604B (zh) | 一种心神安胶囊的中药组合物及其制备方法 | |
| CN116920039B (zh) | 治疗高血脂的中药组合物及其制备方法 | |
| CN1057676C (zh) | 治疗脑萎缩的药物及制法 | |
| CN116098981A (zh) | 一种药食同源的降血脂中药组合物及其制备方法 | |
| CN114404551A (zh) | 改善人类***活力和质量的组合物及其制备和使用方法 | |
| CN116898027A (zh) | 一种中草药饲料添加剂及其制备方法 | |
| CN115487260A (zh) | 一种治疗高胆固醇血症或动脉粥样硬化的中药组合物及其应用 | |
| CN116350705A (zh) | 一种用于治疗肾阴亏损、骨蒸潮热的中药滴丸制剂的制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20221025 |