CN115227767A - 一种治疗高尿酸血症及降低尿酸的中药 - Google Patents
一种治疗高尿酸血症及降低尿酸的中药 Download PDFInfo
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Abstract
本发明涉及中药技术领域,公开了一种治疗高尿酸血症及降低尿酸的中药,包括原料和辅料,所述原料的组分由以下重量份组成:50份黄芪、15份白芍、15份白术、15份毕解、15份肉桂、15份独活、15份人参、15份半下、15份当归、15份云苓、15份防风10、8份川芎、15份附子、15份羌活、15份云羊合、15份枣仁、10份炙草、10份细辛、15份收山虎、15份闰王刺、15份鸟不站、15份冬桑叶和15份黑芝麻,所述辅料由粘合剂和蜜水组成。本发明通过多种纯中药制备成药丸,可以有效地降低高尿酸症患者的血尿酸含量,同时可以增加患者的尿尿酸和尿pH值,并降低血清胆周醇和甘油三酯的含量,彻底治愈患者的高尿酸血症,减少痛风的发作。
Description
技术领域
本发明涉及中药技术领域,具体是一种治疗高尿酸血症及降低尿酸的中药。
背景技术
尿酸是人类嘌呤代谢的终产物,主要经过肾脏***,随着物质生活水平的提高,人们的饮食结构发生改变,长期高嘌吟饮食使高尿酸血症和痛风的发生率逐年增长,长期高尿酸血症易诱发痛风,还容易累及肾脏和心血管***,由于中药在治疗高尿酸症具有用药安全、有效、副作用小,而广泛使用。
中国专利公开了一种治疗高尿酸血症的中药(公告号CN105687901A),该专利技术选择的药材为纯中药制剂,对身体无副作用,并且治疗高尿酸血症效果好,治疗周期短,但是其不能有效地提高尿尿酸的***和尿pH值,并不能有效地降低血清胆周醇和甘油三酯的含量。
发明内容
本发明的目的在于提供一种治疗高尿酸血症及降低尿酸的中药,以解决上述背景技术中提出的问题。
为实现上述目的,本发明提供如下技术方案:
一种治疗高尿酸血症及降低尿酸的中药,包括原料和辅料,所述原料的组分由以下重量份组成:50份黄芪、15份白芍、15份白术、15份毕解、15份肉桂、15份独活、15份人参、15份半下、15份当归、15份云苓、15份防风10、8份川芎、15份附子、15份羌活、15份云羊合、15份枣仁、10份炙草、10份细辛、15份收山虎、15份闰王刺、15份鸟不站、15份冬桑叶和15份黑芝麻,所述辅料由粘合剂和蜜水组成。
作为本发明再进一步的方案:其制备工艺包括以下步骤:
S1、药粉制备:将各原料分别进行清洗,再将清洗干净后的原料分别烘干、粉碎、研磨,过100目筛,将过筛后的药粉经钴-60辐照灭菌,然后将各原料粉按照比例混合,制得药粉;
S2、粘合剂和蜜水制备:取质量份10份纯水煮沸,加入30份炼蜜,同时搅拌至全部溶化,再次煮沸、过滤即可,制得粘合剂;再将10份煮沸纯水与10份炼蜜混合溶化、煮沸、过滤,制得蜜水;
S3、湿药丸制备:在搅拌釜内涂抹一层润滑剂,向搅拌釜内不断加入药粉和粘合剂,并不断搅拌,等结成团块、色泽一直后,再进行揉捏搓条,再通过模具制成黄豆粒大小的湿药丸;
S4、包衣成丸:将湿药丸放入到热风循环箱内干燥,再将干燥后的药丸放入到包衣锅内,在包衣锅转动的过程中,向药丸喷洒蜜水,使药丸湿润均匀,在转动的过程中,使药丸互相摩擦,表面光亮;
S5、消毒包装:打光后的药丸再次放入到热风循环箱内干燥,再通过微波灭菌消毒后,包装分袋,每袋5g,服用方法为每日三次温服,每次一袋。
作为本发明再进一步的方案:所述S2步骤中炼蜜的方法包括以下步骤:
将蜂蜜过滤后,加入到蒸煮锅中加热沸腾,然后除去泡沫和上浮蜡质,当呈现出金黄色至黄棕色稠厚糖浆状液体,手捻有粘性,两手指分开无长白丝出现,迅速出锅,自然冷却,即得到炼蜜。
作为本发明再进一步的方案:所述S3步骤中药粉和粘合剂的质量比为1:0.8~0.9,且S3步骤中润滑剂为甘油或麻油。
作为本发明再进一步的方案:所述S4步骤中湿药丸的干燥温度为55±2℃,湿药丸干燥后水分≤7%。
作为本发明再进一步的方案:所述S5步骤中药丸的干燥温度为60±2℃,干燥时间为180~240℃。
与现有技术相比,本发明的有益效果:
本发明通过多种纯中药制备成药丸,可以有效地降低高尿酸症患者的血尿酸含量,同时可以增加患者的尿尿酸的***,提高尿pH值,并降低血清胆周醇和甘油三酯的含量,彻底治愈患者的高尿酸血症,减少痛风的发作。
具体实施方式
本发明实施例中,一种治疗高尿酸血症及降低尿酸的中药,包括原料和辅料,原料的组分由以下重量份组成:50份黄芪、15份白芍、15份白术、15份毕解、15份肉桂、15份独活、15份人参、15份半下、15份当归、15份云苓、15份防风10、8份川芎、15份附子、15份羌活、15份云羊合、15份枣仁、10份炙草、10份细辛、15份收山虎、15份闰王刺、15份鸟不站、15份冬桑叶和15份黑芝麻,辅料由粘合剂和蜜水组成。
优选的,其制备工艺包括以下步骤:
S1、药粉制备:将各原料分别进行清洗,以去除泥土、杂质,再将清洗干净后的原料分别烘干、粉碎、研磨,过100目筛,将过筛后的药粉经钴-60辐照灭菌,然后将各原料粉按照比例混合,制得药粉;
S2、粘合剂和蜜水制备:取质量份10份纯水煮沸,加入30份炼蜜,同时搅拌至全部溶化,再次煮沸、过滤即可,制得粘合剂;再将10份煮沸纯水与10份炼蜜混合溶化、煮沸、过滤,制得蜜水;
S3、湿药丸制备:在搅拌釜内涂抹一层润滑剂,向搅拌釜内不断加入药粉和粘合剂,并不断搅拌,等结成团块、色泽一直后,再进行揉捏搓条,再通过模具制成黄豆粒大小的湿药丸;
S4、包衣成丸:将湿药丸放入到热风循环箱内干燥,再将干燥后的药丸放入到包衣锅内,在包衣锅转动的过程中,向药丸喷洒蜜水,使药丸湿润均匀,在转动的过程中,使药丸互相摩擦,表面光亮;
S5、消毒包装:打光后的药丸再次放入到热风循环箱内干燥,再通过微波灭菌消毒后,包装分袋,每袋5g,服用方法为每日三次温服,每次一袋。
优选的,S2步骤中炼蜜的方法包括以下步骤:
将蜂蜜过滤后,加入到蒸煮锅中加热沸腾,然后除去泡沫和上浮蜡质,当呈现出金黄色至黄棕色稠厚糖浆状液体,手捻有粘性,两手指分开无长白丝出现,迅速出锅,自然冷却,即得到炼蜜。
优选的,S3步骤中药粉和粘合剂的质量比为1:0.8~0.9,且S3步骤中润滑剂为甘油或麻油,通过润滑剂防止粘连早搅拌釜的内壁和搅拌轴上。
优选的,S4步骤中湿药丸的干燥温度为55±2℃,湿药丸干燥后水分≤7%。
优选的,S5步骤中药丸的干燥温度为60±2℃,干燥时间为180~240℃。
为了更好地说明本发明的技术效果,通过下述实施例进行阐述:
选用本发明制备的中药作为实施例;选用专利网公开的用于治疗痛风及高尿酸血症的中药(公开日:2016-10-12,公开号:CN105998453A)制备的中药作为对比例一,选用专利网公开的一种治疗高尿酸血症的中药(公开日:2016-06-22,公开号:CN105687901A)制备的中药作为对比例二
选取因高尿酸血症入院的患者200例,其中,男性和女性各100例,年龄35~75岁,平均年龄(52.43±14.84)岁,病程1~13年,将200例患者随机分成四组,每组均50例,实施例组、对比例一组、对比例二组和对照组,四组患者的基线资料对比,差异无统计学意义(P>0.05),数据采用SPSS14.0统计学软件进行分析,以平均值±标准差对计量数据表示,计量资料采用t检验,计数资料采用X2检验,P<0.05为有统计学意义;
其中,实施例组、对比例一组、对比例二组分别服用实施例、对比例一和对比例二制备的中药,对照组服用安慰剂;在用药前和用药1个月后,分别测量每组中每例患者的血尿酸(单位:μmol/L)、尿尿酸(单位:mmol/L)、尿pH值、血清胆周醇(单位:mmol/L)和甘油三酯(单位:mmol/L),并计算每组中患者的各项指标的平均值±标准差;并记录到下表1中;
表1血尿酸、尿尿酸、尿pH值、血清胆周醇和甘油三酯的含量
从上表1可以得出:实施例组、对比例一组、对比例二组中的患者血尿酸含量均较大幅度的下降,尿尿酸和尿pH值均较大幅度的增加,血清胆周醇和甘油三酯均较大幅度的降低,具有统计学意义,而对照组中血尿酸、尿尿酸、尿pH值、血清胆周醇和甘油三酯均变化不大,无统计学意义;
同时,实施例组中的患者血尿酸含量下降值大于对比例一组、对比例二组中的患者血尿酸,实施例组中的患者尿尿酸和尿pH值增加值大于对比例一组、对比例二组中的患者尿尿酸和尿pH值增加值,实施例组中的患者血清胆周醇和甘油三酯下降值大于对比例一组、对比例二组中的患者血清胆周醇和甘油三酯下降值。
进而可以得出:本发明制备的中药可以有效地降低高尿酸症患者的血尿酸含量,同时可以增加患者的尿尿酸和尿pH值,从而说明可以提高尿尿酸的***,提高尿pH值,降低血清胆周醇和甘油三酯的含量。
以上所述的,仅为本发明较佳的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,根据本发明的技术方案及其发明构思加以等同替换或改变,都应涵盖在本发明的保护范围之内。
Claims (6)
1.一种治疗高尿酸血症及降低尿酸的中药,包括原料和辅料,其特征在于,所述原料的组分由以下重量份组成:50份黄芪、15份白芍、15份白术、15份毕解、15份肉桂、15份独活、15份人参、15份半下、15份当归、15份云苓、15份防风10、8份川芎、15份附子、15份羌活、15份云羊合、15份枣仁、10份炙草、10份细辛、15份收山虎、15份闰王刺、15份鸟不站、15份冬桑叶和15份黑芝麻,所述辅料由粘合剂和蜜水组成。
2.根据权利要求1所述的一种治疗高尿酸血症及降低尿酸的中药,其特征在于,其制备工艺包括以下步骤:
S1、药粉制备:将各原料分别进行清洗,再将清洗干净后的原料分别烘干、粉碎、研磨,过100目筛,将过筛后的药粉经钴-60辐照灭菌,然后将各原料粉按照比例混合,制得药粉;
S2、粘合剂和蜜水制备:取质量份10份纯水煮沸,加入30份炼蜜,同时搅拌至全部溶化,再次煮沸、过滤即可,制得粘合剂;再将10份煮沸纯水与10份炼蜜混合溶化、煮沸、过滤,制得蜜水;
S3、湿药丸制备:在搅拌釜内涂抹一层润滑剂,向搅拌釜内不断加入药粉和粘合剂,并不断搅拌,等结成团块、色泽一直后,再进行揉捏搓条,再通过模具制成黄豆粒大小的湿药丸;
S4、包衣成丸:将湿药丸放入到热风循环箱内干燥,再将干燥后的药丸放入到包衣锅内,在包衣锅转动的过程中,向药丸喷洒蜜水,使药丸湿润均匀,在转动的过程中,使药丸互相摩擦,表面光亮;
S5、消毒包装:打光后的药丸再次放入到热风循环箱内干燥,再通过微波灭菌消毒后,包装分袋,每袋5g,服用方法为每日三次温服,每次一袋。
3.根据权利要求2所述的一种治疗高尿酸血症及降低尿酸的中药,其特征在于,所述S2步骤中炼蜜的方法包括以下步骤:
将蜂蜜过滤后,加入到蒸煮锅中加热沸腾,然后除去泡沫和上浮蜡质,当呈现出金黄色至黄棕色稠厚糖浆状液体,手捻有粘性,两手指分开无长白丝出现,迅速出锅,自然冷却,即得到炼蜜。
4.根据权利要求2所述的一种治疗高尿酸血症及降低尿酸的中药,其特征在于,所述S3步骤中药粉和粘合剂的质量比为1:0.8~0.9,且S3步骤中润滑剂为甘油或麻油。
5.根据权利要求2所述的一种治疗高尿酸血症及降低尿酸的中药,其特征在于,所述S4步骤中湿药丸的干燥温度为55±2℃,湿药丸干燥后水分≤7%。
6.根据权利要求2所述的一种治疗高尿酸血症及降低尿酸的中药,其特征在于,所述S5步骤中药丸的干燥温度为60±2℃,干燥时间为180~240℃。
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