CN115166876B - Near infrared superlens and light guide optical system for intracranial tumor thermotherapy - Google Patents
Near infrared superlens and light guide optical system for intracranial tumor thermotherapy Download PDFInfo
- Publication number
- CN115166876B CN115166876B CN202110363895.5A CN202110363895A CN115166876B CN 115166876 B CN115166876 B CN 115166876B CN 202110363895 A CN202110363895 A CN 202110363895A CN 115166876 B CN115166876 B CN 115166876B
- Authority
- CN
- China
- Prior art keywords
- near infrared
- light guide
- light
- optical system
- superlens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000003287 optical effect Effects 0.000 title claims abstract description 49
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 37
- 238000007917 intracranial administration Methods 0.000 title claims abstract description 31
- 238000000015 thermotherapy Methods 0.000 title description 3
- 206010020843 Hyperthermia Diseases 0.000 claims abstract description 28
- 230000036031 hyperthermia Effects 0.000 claims abstract description 28
- 239000002086 nanomaterial Substances 0.000 claims abstract description 25
- 229910052751 metal Inorganic materials 0.000 claims abstract description 22
- 239000002184 metal Substances 0.000 claims abstract description 22
- 239000000758 substrate Substances 0.000 claims abstract description 21
- 239000010935 stainless steel Substances 0.000 claims description 4
- 229910001220 stainless steel Inorganic materials 0.000 claims description 4
- 229910000990 Ni alloy Inorganic materials 0.000 claims description 3
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract 1
- 239000002061 nanopillar Substances 0.000 description 61
- 238000010586 diagram Methods 0.000 description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 238000002834 transmittance Methods 0.000 description 7
- 229910021417 amorphous silicon Inorganic materials 0.000 description 6
- 230000009977 dual effect Effects 0.000 description 6
- 239000002105 nanoparticle Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 239000010453 quartz Substances 0.000 description 4
- 239000002210 silicon-based material Substances 0.000 description 4
- 238000012377 drug delivery Methods 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 230000010287 polarization Effects 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000008499 blood brain barrier function Effects 0.000 description 2
- 210000001218 blood-brain barrier Anatomy 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 239000005331 crown glasses (windows) Substances 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 229910021419 crystalline silicon Inorganic materials 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000010587 phase diagram Methods 0.000 description 1
- 239000004038 photonic crystal Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/002—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of materials engineered to provide properties not available in nature, e.g. metamaterials
- G02B1/007—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of materials engineered to provide properties not available in nature, e.g. metamaterials made of negative effective refractive index materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0625—Warming the body, e.g. hyperthermia treatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y20/00—Nanooptics, e.g. quantum optics or photonic crystals
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B19/00—Condensers, e.g. light collectors or similar non-imaging optics
- G02B19/0033—Condensers, e.g. light collectors or similar non-imaging optics characterised by the use
- G02B19/0047—Condensers, e.g. light collectors or similar non-imaging optics characterised by the use for use with a light source
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01Q—ANTENNAS, i.e. RADIO AERIALS
- H01Q15/00—Devices for reflection, refraction, diffraction or polarisation of waves radiated from an antenna, e.g. quasi-optical devices
- H01Q15/0006—Devices acting selectively as reflecting surface, as diffracting or as refracting device, e.g. frequency filtering or angular spatial filtering devices
- H01Q15/0086—Devices acting selectively as reflecting surface, as diffracting or as refracting device, e.g. frequency filtering or angular spatial filtering devices said selective devices having materials with a synthesized negative refractive index, e.g. metamaterials or left-handed materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nanotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The invention provides a near infrared superlens and a light guide optical system for intracranial tumor hyperthermia, comprising: a substrate that is transparent to near infrared light; the surface structure units are arranged on the same surface of the substrate, the surface structure units are in array arrangement, the surface structure units are regular hexagons and/or squares, and the center position of each surface structure unit or the center position and the vertex position of each surface structure unit are respectively provided with a nano structure; the super surface structure unit can efficiently transmit light with a near infrared band of 925 to 955 nm. The light guide optical system adopts the near infrared superlens to replace the traditional lens, and the volume of the whole optical system is greatly reduced by the near infrared superlens, so that the diameter of the metal sleeve is reduced, the diameter of a needed cranium opening is further reduced, and the good effect of relieving the pain of a patient is achieved.
Description
Technical Field
The invention relates to the field of superlenses, in particular to a near infrared superlens and a light guide optical system for intracranial tumor hyperthermia.
Background
The blood brain barrier prevents traditional antitumor drugs from entering intracranial tumors through the blood. Tumor hyperthermia is carried out by precisely delivering photo-thermal nano-particles to a tumor area through a drug delivery pipeline wrapped in a metal needle head through craniocerebral perforation, and then irradiating the tumor absorbing the nano-particles through a light guide system. The nanoparticle absorbs infrared light and rapidly heats up to kill tumor cells. Conventional light guide systems require a conventional lens mounted on the end face of the light guide waveguide to disperse the infrared light. However, the conventional lens has disadvantages in terms of large volume, complex structure, difficulty in integration, and the like.
Disclosure of Invention
Aiming at the technical problems, the embodiment of the invention provides a near infrared super lens and a light guide optical system comprising the same for intracranial tumor hyperthermia.
A first aspect of an embodiment of the present invention provides a near infrared superlens, including:
A substrate that is transparent to near infrared light; and
The surface structure units are arranged on the same surface of the substrate, the surface structure units are in array arrangement, the surface structure units are regular hexagons and/or squares, and the center position of each surface structure unit or the center position and the vertex position of each surface structure unit are respectively provided with a nano structure; the super surface structure unit can efficiently transmit light with a near infrared band of 925 to 955 nm.
Optionally, the nano-structure is a nano-pillar structure, and the nano-pillar structure is one of a round nano-pillar structure, a square nano-pillar structure, a round hole nano-pillar structure and a square hole nano-pillar structure; the nanostructures in different locations have different optical phases at different wavelengths.
Optionally, the substrate is quartz glass or schottky glass or crown glass, and the thickness of the substrate is 0.05 to 1mm.
Optionally, the phase of the near infrared superlens satisfies the divergent lens phase:
wherein, In order to disperse the phase distribution of the super lens to the infrared light, r is the position of the surface of the near infrared super lens along the radial direction, lambda is in the near infrared light with the wave band of 915-955nm, f is the focal length of the divergent super lens to the near infrared light, and the focal length is a negative number; the phase of the near infrared superlens satisfies the phase distribution of the multifocal lens.
The near infrared superlens has the advantages of simple structure, light weight and small volume, and is easy to integrate.
A second aspect of embodiments of the present invention provides a light guiding optical system for intracranial tumor hyperthermia, comprising:
A metal sleeve;
At least one light guide with one end positioned in the metal sleeve;
the near infrared light source is positioned at the other end of at least one light guide waveguide;
The near infrared super lens as claimed in any one of the above, which is disposed at one end of the at least one light guide away from the near infrared light source;
Preferably, at least one turning prism is also included.
Optionally, the light guiding optical system for intracranial tumor hyperthermia comprises a plurality of light guiding waveguides, a plurality of near infrared superlenses corresponding to the number of the light guiding waveguides; preferably, the light guiding optical system for intracranial tumor hyperthermia further comprises a plurality of turning prisms corresponding to the plurality of the light guiding waveguides, wherein one end face of the turning prism is adhered to the end face of the light guiding waveguide, and the other end face of the turning prism is adhered to the near infrared superlens.
Optionally, the metal sleeve is made of metal with good rigidity, high toughness and strong corrosion resistance; preferably, the inner diameter of the metal sleeve is 1mm-3mm, and the outer diameter is 1.2mm-3.2mm; preferably, the metal sleeve is a stainless steel sleeve, a titanium alloy sleeve or a nickel alloy sleeve.
Optionally, the near infrared light source is a laser or a high-power LED with a center wavelength of 940 nm.
Optionally, the light guide may conduct near infrared light at 925-955 nm; the diameter of the light guide is 50-500 μm.
Optionally, the light guiding optical system for intracranial tumor hyperthermia comprises a light guiding waveguide and a near infrared superlens attached to the end face of the light guiding waveguide.
The light guide optical system for intracranial tumor thermotherapy is provided by the second aspect of the invention, wherein the near infrared superlens is arranged at one end of the light guide waveguide, one end of which is positioned in the metal sleeve, and the other end of the light guide waveguide is connected with the near infrared light source, and is far away from the near infrared light source.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention as claimed.
Drawings
FIG. 1 is a schematic diagram of a near infrared super lens structure according to an embodiment of the invention;
FIG. 2A is a diagram of a regular hexagonal arrangement of hypersurfaces in an embodiment of the present invention;
FIG. 2B is a square arrangement of the hypersurface in an embodiment of the invention;
FIG. 3A is a schematic diagram of a circular nanopillar structure in an embodiment of the invention;
FIG. 3B is a schematic diagram of a round hole nanopillar structure in an embodiment of the invention;
FIG. 3C is a schematic diagram of a square nano-pillar structure according to an embodiment of the present invention;
FIG. 3D is a schematic diagram of a square hole nanopillar structure in an embodiment of the invention;
FIG. 4A is a graph of the operating wavelength 925-955nm optical phase versus the diameter of the nanopillar structure of the quartz substrate and amorphous silicon material in an embodiment of the invention;
FIG. 4B is a graph of operating wavelength 925-955nm light transmittance versus diameter for a quartz substrate and a nano-pillar structure of amorphous silicon material in accordance with an embodiment of the present invention;
FIG. 4C is a graph showing the relationship between the operating wavelength 925-955nm optical phase and the square nano-pillar structure number of the quartz substrate and amorphous silicon material according to an embodiment of the present invention;
FIG. 4D is a graph showing the relationship between the transmittance of light at the operating wavelength of 925-955nm and the square nano-pillar structure of the quartz substrate and amorphous silicon material according to an embodiment of the present invention;
FIG. 5A is a graph of negative lens radius versus phase for a working wavelength of 940nm with a diameter of 62.5 μm, a focal length of-18 μm, and a divergence angle of 120℃in an embodiment of the present invention;
FIG. 5B is a phase diagram of a multi-point lens with a working wavelength of 940nm, a diameter of 62.5 μm, a focal length of 18 μm, and four focal points on the focal plane, in accordance with an embodiment of the present invention;
FIG. 6 is a schematic diagram of a light-guiding optical system for intracranial tumor hyperthermia in an embodiment of the invention;
FIG. 7A is a schematic view of a light guide system in which the near infrared superlens shown in FIG. 5A is attached to a light guide having a diameter of 62.5 μm;
FIG. 7B is a schematic view of a light guide system in which the near infrared superlens shown in FIG. 5B is attached to a light guide having a diameter of 62.5 μm;
FIG. 7C is a schematic diagram of a light guide system comprising a dual optical waveguide, a dual turning prism, and dual near infrared in accordance with one embodiment of the present invention;
FIG. 8 is a graph of the relative intensity profile of the system of FIG. 7A at 18 μm behind a near infrared superlens;
FIG. 9 is a graph of the relative intensity profile at the near infrared superlens focal plane of the system shown in FIG. 7B;
Reference numerals:
100: a near infrared superlens;
1: a substrate;
2: a super surface structural unit; 21: a nanostructure; 211: a circular nanopillar structure; 212: a round hole nano-pillar structure; 2121: a first column; 2122: a first hollow portion; 213: square nano-pillar structure; 214: square hole nano-pillar structure; 2141: a fourth column; 2142: a fourth hollow portion;
a metal sleeve 31, a light guide 32, a near infrared light source 33, a turning prism 34 and a medicine delivery tube 35.
Detailed Description
Reference will now be made in detail to exemplary embodiments, examples of which are illustrated in the accompanying drawings. When the following description refers to the accompanying drawings, the same numbers in different drawings refer to the same or similar elements, unless otherwise indicated. The implementations described in the following exemplary examples do not represent all implementations consistent with the invention. Rather, they are merely examples of apparatus and methods consistent with aspects of the invention as detailed in the accompanying claims.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used in this specification and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It should also be understood that the term "and/or" as used herein refers to and encompasses any or all possible combinations of one or more of the associated listed items.
It should be understood that although the terms first, second, third, etc. may be used herein to describe various information, these information should not be limited by these terms. These terms are only used to distinguish one type of information from another. For example, first information may also be referred to as second information, and similarly, second information may also be referred to as first information, without departing from the scope of the invention. The word "if" as used herein may be interpreted as "at … …" or "at … …" or "in response to a determination" depending on the context. The features of the examples and embodiments described below may be combined with each other without conflict.
The blood brain barrier prevents traditional antitumor drugs from entering intracranial tumors through the blood. Tumor hyperthermia is carried out by precisely delivering photo-thermal nano-particles to a tumor area through a drug delivery pipeline wrapped in a metal needle head through craniocerebral perforation, and then irradiating the tumor absorbing the nano-particles through a light guide system. The nanoparticle absorbs infrared light and rapidly heats up to kill tumor cells. Conventional light guide systems require a conventional lens mounted on the end face of the light guide waveguide to disperse the infrared light. However, the conventional lens has disadvantages in terms of large volume, complex structure, difficulty in integration, and the like.
Optical supersurfaces are rapidly emerging and become a dominant way of achieving miniaturized, planarized optics. Optical supersurfaces have been shown to be based on supersurface axicon lenses, blazed gratings, polarizers, holographic dryplates and planar lenses. The continuous 2 pi phase varying supersurface enables single layer aplanatic superlenses. At the same time, achromatic supersurfaces are also used for white light imaging.
Embodiment one:
A first aspect of an embodiment of the present invention provides a near infrared superlens 100, comprising: a substrate that is transparent to near infrared light; and a plurality of super-surface structural units arranged on the same surface of the substrate. For example, referring to fig. 1, the near infrared super lens is composed of a substrate 1 and a plurality of super surface structure units 2 disposed on one side of the substrate 1. Wherein a plurality of the super-surface structural units 2 are arranged in an array manner, the super-surface structural units 2 are regular hexagons and/or squares, and the center position of each super-surface structural unit 2 or the center position and the vertex position of each super-surface structural unit 2 are respectively provided with a nano structure 21; the super-surface structure unit 2 can efficiently transmit light in a near infrared band, and the near infrared band is 925-955nm.
Alternatively, the substrate 1 is quartz glass or schottky glass or crown glass, and the thickness of the substrate 1 is 0.05mm to 1mm. Illustratively, the substrate 1 is made of a material with high transmittance of the first near infrared light and the second near infrared light, such as quartz glass, K9 glass, and the like. The substrate 1 has a thickness of between 0.05mm and 1mm, and the thickness may be set to 0.05mm, 0.1mm, 0.2mm, 0.3mm, 0.4mm, 0.5mm, 0.6mm, 0.7mm, 0.8mm, 0.9mm, 1mm, and the like.
For example, referring to fig. 2B, a nanostructure 21 is disposed at a central position of each of the super surface structural units 2, and the nano structures 21 of the super surface structural units 2 of the near infrared super lens are formed in the array arrangement, and the performance of the formed super surface structural units 2 meets the requirement; for example, referring to fig. 2A, the vertex position of each of the super surface structure units 2 and the center position of each of the super surface structure units 2 are provided with one nanostructure 21, respectively.
For example, in some embodiments, referring to fig. 2A, all of the super surface structure units 2 are regular hexagons; in other embodiments, referring to fig. 2B, all of the super surface structure units 2 are square; in other embodiments, the plurality of super surface structure units 2 includes regular hexagonal array units and square super surface structure units 2. It should be appreciated that in other embodiments, the super surface structure unit 2 may be designed in other close-packed or fan-shaped structures.
In this embodiment, the nanostructure 21 may have an average transmittance of greater than 80% at 915-955nm (center wavelength 940 nm).
In this embodiment, the nanostructures 21 are axisymmetric along the first axis and the second axis, and the plurality of nanostructure units obtained by splitting the nanostructures 21 along the first axis and the second axis are the same, and the structure is insensitive to polarization of incident light. The first shaft and the second shaft are perpendicular, and the first shaft and the second shaft are perpendicular to the height direction of the nano structure respectively. It should be noted that, the first axis and the second axis pass through the center of the nanostructure 21 and are parallel to the horizontal plane, and one straight line passing through the center of the nanostructure 21 may be arbitrarily selected as the first axis, and the other straight line perpendicular to the first axis and passing through the center is the second axis.
In this embodiment, the optical phases of the nanostructures 21 at different locations are different at different wavelengths to define the optical phase distribution of the super surface structure unit at different wavelengths. It should be noted that, the entire structure formed by the plurality of nanostructures 21 according to the embodiment of the present invention can transmit near infrared light with high transmittance.
Illustratively, the nanostructure 21 may be made of quartz glass, crystalline silicon or amorphous silicon; it should be understood that the material of the nano-pillars may be other materials besides those described above.
The nanostructures 21 may be, for example, nanopillar structures, or other nanostructures that are axisymmetric along the horizontal and vertical axes, respectively.
Next, a description will be given of an example in which the nanostructure 21 is a nanopillar structure; it should be understood that when the nanostructure 21 is other structures, the nanopillar structures in the embodiments described below may be replaced with corresponding structures.
The nano-pillar structures may include at least one of a circular nano-pillar structure 211, a circular hole nano-pillar structure 212, a square nano-pillar structure 213, and a square hole nano-pillar structure 214. Illustratively, the nano-pillar structure is one of a circular nano-pillar structure 211, a round hole nano-pillar structure 212, a square nano-pillar structure 213, and a square hole nano-pillar structure 214, which is convenient for processing.
In the embodiment of the application, the optical phase of the nano structure, the height and the cross section shape of the nano column structure and the material of the nano column structure.
Referring to fig. 3A to 3D, the height of the nano-pillar structure (i.e., the height of the nano-pillar structure in the z direction) is H.
The height H of the nanopillar structures is greater than or equal to 300nm and less than or equal to 3500nm, the spacing between adjacent nanopillar structures (i.e., the spacing between the centers of two adjacent nanopillar structures) is greater than or equal to 40nm and less than or equal to 640nm, and the minimum dimension of the nanopillar structures and the minimum spacing between two adjacent nanopillar structures (i.e., the minimum distance between the edges of two adjacent nanopillars) may be 40nm. Exemplary, the height H of the nanopillar structure is 300nm, 400nm, 500nm, 600nm, 700nm, 800nm, 900nm, 1000nm, 1100nm, 1200nm, 1300nm, 1400nm, 2500nm, 3500nm, or the like. Illustratively, the spacing between adjacent nanopillar structures is 40nm, 140nm, 240nm, 340nm, 440nm, 540nm, 640nm, or the like.
Referring to fig. 3A, the circular nano-pillar structures 211 may include a first cylinder, which is a solid structure. The circular nanopillar structure 211 has a cross-sectional diameter d in the x-y plane ranging between 40nm and 600nm, e.g., d may be set to 40nm, 50nm, 150nm, 200nm, 250nm, 300nm, 350nm, 400nm, 500nm, 600nm, etc.
Referring to fig. 3B, the round hole nano-pillar structure 212 may include a first cylinder 2121, wherein a cross-section of the first cylinder 2121 has the same shape as that of the super surface structure unit 2, and when the super surface structure unit 2 is hexagonal, the cross-section of the first cylinder 2121 is hexagonal; when the super surface structure unit 2 is square, the cross-section of the first cylinder 2121 is also square in shape. In this embodiment, the size of the cross section of the first cylinder 2121 is the same as the size of the super surface structural unit 2. The first cylinder 2121 is provided with a cylindrical first hollow 2122 extending from the top to the bottom thereof, and the first cylinder 2121 and the first hollow 2122 are coaxial. The circular hole nanopillar structure 212 has a cross-sectional diameter d in the x-y plane (i.e., cross-section) ranging from 40nm to 600nm, e.g., d can be set to 40nm, 50nm, 150nm, 200nm, 250nm, 300nm, 350nm, 400nm, 500nm, 600nm, etc.
Referring to fig. 3C, the square nano-pillar structures 213 may include a third pillar, the third pillar is a solid structure, and the cross-section of the third pillar is square.
Referring to fig. 3D, the square hole nano-pillar structure 214 may include a fourth cylinder 2141, the cross-section of the fourth cylinder 2141 has the same shape as the super surface structure unit 2, and when the super surface structure unit 2 is hexagonal, the cross-section of the fourth cylinder 2141 is also hexagonal; when the super surface structure unit 2 is square, the cross-section of the fourth cylinder 2141 is also square in shape. In this embodiment, the cross section of the fourth cylinder 2141 has the same size as the super surface structure unit 2. Further, the fourth column 2141 is provided with a fourth hollow portion 2142 extending from the top to the bottom thereof, the cross-section of the fourth hollow portion 2142 is square in shape, and the fourth column 2141 is coaxial with the fourth middle portion.
Illustratively, in certain embodiments, the nanopillar structure is a circular nanopillar structure. For the design working at the near infrared wavelength of 925-955nm, the material of the round nano-pillar structure is amorphous silicon, the round nano-pillar structure 211 adopts the round nano-pillar structure shown in fig. 4A, the height H of the round nano-pillar structure 211 is 600nm, and the corresponding side of the regular hexagon basic unit is 550nm. FIG. 4A shows the relationship between the optical phase of the near infrared superlens and the diameter of the circular nanopillar structure 211 at near infrared wavelengths 925-955nm, and the optical phase at 925-955nm on the abscissa in FIG. 4A. FIG. 4B shows the relationship between the transmittance of the near infrared superlens and the diameter of the circular nano-pillar structure 211 at the near infrared wavelength of 925-955nm, and the optical phase at 925-955nm, with the diameter of the circular nano-pillar structure 211 on the abscissa in FIG. 4B. FIG. 4C shows the relationship between the optical phase of the near infrared superlens and the number of square nano-pillar structures 213 at near infrared wavelengths 925-955nm, and the optical phase at 925-955nm is shown on the abscissa in FIG. 4C, where the square nano-pillar structures 213 are numbered on the abscissa. Fig. 4D shows the relationship between the transmittance of the near infrared superlens and the number of the square nano-pillar structures 213, and fig. 4D shows the optical phase at 925-955nm, with the number of the square nano-pillar structures 213 on the abscissa.
Illustratively, the phase of the near infrared superlens satisfies the divergent lens phase:
wherein, In order to disperse the phase distribution of the super lens to the infrared light, r is the position of the near infrared super lens surface along the radius direction, lambda is in the near infrared light 915-955nm, and f is the focal length (the focal length is negative) of the super lens to the near infrared light. Referring to FIG. 5A, in some embodiments, the near infrared superlens has a diameter of 62.5 μm at 940nm, a focal length of-18 μm, and a divergence angle of 120 degrees.
Illustratively, the phase of the near infrared superlens satisfies a multifocal lens phase distribution, which may be derived by an optimization algorithm. Referring to FIG. 5B, in some embodiments, the operating wavelength is 62.5 μm in diameter at 940nm, the focal length is 18 μm, and the focal plane has a near infrared superlens surface phase map with four foci.
Embodiment two:
a second aspect of an embodiment of the present invention provides a light guiding optical system for intracranial tumor hyperthermia, please refer to fig. 6, comprising:
a metal sleeve 31;
At least one light guide 32 having one end thereof located within the metal sleeve 31;
a near infrared light source 33 located at the other end of at least one of the light guide guides 32;
At least one near infrared superlens 100 as claimed in any one of the above, disposed at an end of at least one of the light guide 32 remote from the near infrared light source 33.
The light guide optical system for intracranial tumor hyperthermia based on the near infrared superlens 100 replaces the traditional lens with the near infrared superlens 100, so the light guide optical system for intracranial tumor hyperthermia has the advantages of simple structure, light weight, small volume and easy integration. In addition, the near infrared superlens 100 greatly reduces the volume of the whole optical system, thereby reducing the diameter of the metal sleeve 31, further reducing the diameter of the needed cranium opening, and playing a role in relieving the pain of patients.
As a preferred embodiment of the present invention, the light guiding optical system for intracranial tumor hyperthermia comprises a plurality of light guiding waveguides 32, a plurality of near infrared superlenses 100 according to any one of the above corresponding number of the light guiding waveguides 32; as shown in fig. 7C, the light guiding optical system for intracranial tumor hyperthermia further includes a plurality of turning prisms 34 corresponding to the plurality of the light guiding waveguides 32, wherein one end surface of the turning prism 34 is adhered to the end surface of the light guiding waveguide 32, and the other end surface of the turning prism 34 is adhered to the near infrared superlens 100. A drug delivery tube 35 is provided on one side of the light guide 32. When including a plurality of the light guide guides 32 and a plurality of turning prisms 34, it is possible to ensure that the light guide optical system for intracranial tumor hyperthermia more fully covers the full spatial angle.
The metal sleeve 31 is made of metal with good rigidity, high toughness and strong corrosion resistance; preferably, the metal sleeve is made of stainless steel, and has an inner diameter of 1mm-3mm and an outer diameter of 1.2mm-3.2mm; in this embodiment, the metal sleeve 31 is preferably a stainless steel sleeve, a titanium alloy sleeve, or a nickel alloy sleeve.
Optionally, the near infrared light source 33 is a laser or a high-power LED with a center wavelength of 940 nm. Illustratively, the laser output optical power with the center wavelength at 940nm is adjustable from 0 to 10000mW; the half divergence angle is less than 2 degrees, and the light polarization state is circular polarization. Exemplary, the LED light source with a center wavelength of 940nm has a half divergence angle of less than 10 °, a spectral width of 30nm, and an output light power of 5W. The near infrared light source 33 may be only one, and when the light guide 32 is plural, the near infrared light source 33 is divided into plural bundles by the light guide 32.
Optionally, the light guide may conduct near infrared light at 925-955 nm; the diameter of the light guide is 50-500 μm. Preferably, the light guide 32 is one of a single mode fiber, a multimode fiber and a photonic crystal fiber.
As another preferred embodiment of the present invention, the light guiding optical system for intracranial tumor hyperthermia may also include a light guiding waveguide 32 and a near infrared superlens 100 as described above attached to the end surface of the light guiding waveguide 32. This can make the structure of the near infrared super lens 100 simpler, mature, highly reliable and easier to integrate.
For example, please refer to fig. 7A and 7B, wherein fig. 7A is a schematic diagram of a light guiding system formed by attaching the near infrared super lens shown in fig. 5A to a light guiding waveguide with a diameter of 62.5 μm; FIG. 7B is a schematic view of a light guide system in which the near infrared superlens shown in FIG. 5B is attached to a light guide waveguide having a diameter of 62.5. Mu.m.
For example, please refer to fig. 7C, wherein fig. 7C is a schematic diagram of a light guiding system composed of a dual optical waveguide, a dual turning prism and dual near infrared. The two turning prisms respectively guide light to two opposite half spaces, and the maximum range of the full space is covered after light is scattered by the two near infrared superlenses 100.
For example, please refer to fig. 8, fig. 8 is a graph showing the relative light intensity distribution of the system of fig. 7A at 18 μm (reference plane) behind the near infrared superlens. Wherein the on-axis light intensity on the reference plane is highest and the edge point is lowest.
For example, referring to FIG. 9, FIG. 9 is a graph of the relative intensity profile of the system of FIG. 7B at the near infrared superlens focal plane. Wherein four focuses are symmetrically distributed on the focal plane.
The above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (9)
1. A light-guiding optical system for intracranial tumor hyperthermia, comprising:
A metal sleeve;
At least one light guide with one end positioned in the metal sleeve;
The near infrared light source is positioned at the other end of at least one light guide waveguide; at least one near infrared superlens as a heat conduction device, which is arranged at one end of at least one light guide waveguide far away from the near infrared light source; the near infrared superlens is used for diverging infrared rays;
The near infrared superlens comprises: a substrate that is transparent to near infrared light; and
The surface structure units are arranged on the same surface of the substrate, the surface structure units are in array arrangement, the surface structure units are regular hexagons and/or squares, and the center position of each surface structure unit or the center position and the vertex position of each surface structure unit are respectively provided with a nano structure; the super-surface structural unit can efficiently transmit light with a near infrared band of 925-955 nm.
2. The light-guiding optical system for hyperthermia of intracranial tumors as recited in claim 1, further comprising at least one turning prism.
3. The light guide optical system for intracranial tumor hyperthermia according to claim 1, wherein the light guide optical system for intracranial tumor hyperthermia comprises a plurality of light guide waveguides, and a plurality of the near infrared superlenses corresponding to the number of the light guide waveguides.
4. The light guide optical system for intracranial tumor hyperthermia according to claim 3, further comprising a plurality of turning prisms corresponding to the plurality of the light guide waveguides, wherein one end face of the turning prism is bonded to the light guide waveguide end face, and the other end face of the turning prism is bonded to the near infrared superlens.
5. The light-guiding optical system for hyperthermia of intracranial tumor according to claim 1, wherein the metal sleeve has an inner diameter of 1mm-3mm and an outer diameter of 1.2mm-3.2mm.
6. The light-guiding optical system for intracranial tumor hyperthermia according to claim 1, wherein the metal sleeve is a stainless steel sleeve, a titanium alloy sleeve or a nickel alloy sleeve.
7. The light-guiding optical system for intracranial tumor hyperthermia according to claim 1, wherein the near infrared light source is a laser or LED with a central wavelength of 940 nm.
8. The light-guiding optical system for intracranial tumor hyperthermia according to claim 1, wherein the light-guiding waveguide is capable of conducting near infrared light of 925-955 nm; the diameter of the light guide is 50-500 μm.
9. The light guide optical system for intracranial tumor hyperthermia according to claim 1, wherein the light guide optical system for intracranial tumor hyperthermia comprises a light guide waveguide and a near infrared superlens attached to an end face of the light guide waveguide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110363895.5A CN115166876B (en) | 2021-04-02 | 2021-04-02 | Near infrared superlens and light guide optical system for intracranial tumor thermotherapy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110363895.5A CN115166876B (en) | 2021-04-02 | 2021-04-02 | Near infrared superlens and light guide optical system for intracranial tumor thermotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115166876A CN115166876A (en) | 2022-10-11 |
| CN115166876B true CN115166876B (en) | 2024-04-26 |
Family
ID=83476176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110363895.5A Active CN115166876B (en) | 2021-04-02 | 2021-04-02 | Near infrared superlens and light guide optical system for intracranial tumor thermotherapy |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115166876B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200047612A (en) | 2017-08-31 | 2020-05-07 | 메탈렌츠 인코포레이티드 | Transmissive metasurface lens integration |
| US11978752B2 (en) | 2019-07-26 | 2024-05-07 | Metalenz, Inc. | Aperture-metasurface and hybrid refractive-metasurface imaging systems |
| US11927769B2 (en) | 2022-03-31 | 2024-03-12 | Metalenz, Inc. | Polarization sorting metasurface microlens array device |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110376665A (en) * | 2019-07-31 | 2019-10-25 | 郝成龙 | A kind of super lens and the optical system with it |
| CN115047432A (en) * | 2021-03-09 | 2022-09-13 | 深圳迈塔兰斯科技有限公司 | Double-spectrum super-surface and point cloud generating device and laser radar transmitting system |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200008630A (en) * | 2017-05-24 | 2020-01-28 | 더 트러스티스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 | Broadband achromatic flat optical component by distributed engineered dielectric metasurface |
| US11815703B2 (en) * | 2018-12-03 | 2023-11-14 | Samsung Electronics Co., Ltd. | Meta-lens and optical apparatus including the same |
-
2021
- 2021-04-02 CN CN202110363895.5A patent/CN115166876B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110376665A (en) * | 2019-07-31 | 2019-10-25 | 郝成龙 | A kind of super lens and the optical system with it |
| CN115047432A (en) * | 2021-03-09 | 2022-09-13 | 深圳迈塔兰斯科技有限公司 | Double-spectrum super-surface and point cloud generating device and laser radar transmitting system |
Non-Patent Citations (1)
| Title |
|---|
| Nano-optic endoscope for high-resolution optical coherence tomography in vivo;Hamid Pahlevaninezhad等;《Nature Photonics》;第12卷(第9期);正文第540-547页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115166876A (en) | 2022-10-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN115166876B (en) | Near infrared superlens and light guide optical system for intracranial tumor thermotherapy | |
| US6829411B2 (en) | Wide angle light diffusing optical fiber tip | |
| WO2022007738A1 (en) | Large-aperture chromatic aberration correction metalens, metalens system, and optical system | |
| CN106170728B (en) | Beam shaping system and the illumination system for using it | |
| WO2021233416A1 (en) | Hybrid optical system having superlens and refraction and/or reflection lens | |
| JP6110399B2 (en) | Multi-spot laser probe with facet optics | |
| US20180140172A1 (en) | Apparatus, systems, and methods for biomedical imaging and stimulation | |
| US8561280B2 (en) | Assembling a multi-fiber multi-spot laser probe | |
| TWI444745B (en) | Optical path switching device and method for switching the optical path for optical signals | |
| CN115047432A (en) | Double-spectrum super-surface and point cloud generating device and laser radar transmitting system | |
| DE60136531D1 (en) | Method of designing and producing highly efficient non-imaging optics | |
| US20150062573A1 (en) | Optical detection device and optical detection method | |
| CN207352292U (en) | A kind of optical fiber output laser | |
| US20060233492A1 (en) | Optical beam combiner/concentrator | |
| CN101194857B (en) | Laser lancet | |
| US20190020170A1 (en) | Single optical fiber-based multi-ring laser beam device, and manufacturing method therefor | |
| TW200925511A (en) | TIR collimator with improved uniformity | |
| CN113406046A (en) | Near-infrared light sheet microscope | |
| CN203217180U (en) | 1064nm / 532nm dual-band beam expander | |
| US8276283B1 (en) | Reticle etched within optical lens | |
| CN207532375U (en) | The imaging system of human microvascular three-dimensional ultra microstructure based on effluent dark field imaging technique | |
| KR100870446B1 (en) | Lens arrangment for making microthermal treatment zone | |
| CN203217181U (en) | Dual-band beam expander optical system | |
| CN221039507U (en) | Side-shooting optical fiber assembly | |
| Darafsheh et al. | Chains of variable size spheres for focusing of multimodal beams in photonics applications |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |