CN115137899A - Multifunctional artificial organ device - Google Patents

Multifunctional artificial organ device Download PDF

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Publication number
CN115137899A
CN115137899A CN202210726199.0A CN202210726199A CN115137899A CN 115137899 A CN115137899 A CN 115137899A CN 202210726199 A CN202210726199 A CN 202210726199A CN 115137899 A CN115137899 A CN 115137899A
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CN
China
Prior art keywords
blood
housing
tube bundle
mounting
blood tube
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Pending
Application number
CN202210726199.0A
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Chinese (zh)
Inventor
周金生
李平
孙志远
林晨
高文丹
覃苏萍
郑立新
李珺
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Shenzhen Huayuan Regeneration Medical Science Co ltd
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Shenzhen Huayuan Regeneration Medical Science Co ltd
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Application filed by Shenzhen Huayuan Regeneration Medical Science Co ltd filed Critical Shenzhen Huayuan Regeneration Medical Science Co ltd
Priority to CN202210726199.0A priority Critical patent/CN115137899A/en
Publication of CN115137899A publication Critical patent/CN115137899A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit

Abstract

The invention discloses a multifunctional artificial organ device, which comprises a shell, a blood tube bundle and hydrogel, wherein the blood tube bundle is contained in a containing cavity, the blood tube bundle is communicated with a blood inlet and a blood outlet, the hydrogel is filled in the containing cavity, the hydrogel comprises a gel layer and allogeneic therapeutic cells, the allogeneic therapeutic cells are wrapped in the gel layer, and the allogeneic therapeutic cells absorb nutrient substances and oxygen separated out by the blood tube bundle and secrete therapeutic factors to the blood tube bundle. In the multifunctional artificial visceral organ device provided by the embodiment of the invention, allogeneic therapeutic cells are wrapped inside the gel layer to reduce the immunologic rejection of a human body, blood of the human body is filtered through the blood tube bundle, nutrient substances and oxygen are separated out from the blood tube bundle to supply the allogeneic therapeutic cells for normal metabolism, and the allogeneic therapeutic cells generate therapeutic factors, and the therapeutic factors flow to the visceral organs along with the blood to achieve the purpose of treating diseases.

Description

Multifunctional artificial organ device
Technical Field
The invention relates to the technical field of medical instruments, in particular to a multifunctional artificial visceral organ device.
Background
In the case of injury or loss of function of a patient's organ, it is common in the clinic to replace the patient's organ with a fully functioning allogeneic donor organ by means of organ transplantation. However, in the actual situation, a large number of patients are limited by the shortage of donor organs and cannot be cured in time, and the organ transplantation operation, whether in-situ transplantation or heterotopic transplantation, has great operation difficulty; and the allogeneic donor organ is often affected by the immune components of the human body, resulting in rejection after surgery and failure. When the implanted foreign body organ is in a state, the transplantation operation needs to be carried out again, which not only causes secondary damage to the patient, but also causes permanent immunological rejection. Therefore, there is a need to find a device with low rejection response in clinic, which can be used for treating organ damage or loss of function diseases of patients.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art. Therefore, the invention provides a multifunctional artificial organ device which can treat organ injury or cell function loss diseases and reduce the rejection strength of immune components of a human body.
According to an embodiment of the present invention, a multifunctional artificial organ device includes:
the blood collection device comprises a shell, a blood collection device and a control device, wherein a containing cavity is arranged inside the shell, the shell is provided with a blood inlet and a blood outlet, and the blood inlet and the blood outlet are communicated with the containing cavity;
a plurality of blood tube bundles, wherein the blood tube bundles are accommodated in the accommodating cavity, one end of each blood tube bundle is communicated with the blood inlet, and the other end of each blood tube bundle is communicated with the blood outlet;
hydrogel, fill in hold the intracavity, hydrogel includes gel layer and xenogenesis treatment cell, xenogenesis treatment cell parcel in the inside of gel layer, xenogenesis treatment cell absorbs follow the material of blood tube bank separation out and to hold the chamber secretion treatment factor.
The multifunctional artificial visceral organ device provided by the embodiment of the invention at least has the following beneficial effects:
in the multifunctional artificial visceral organ device provided by the embodiment of the invention, the allogeneic therapeutic cells are wrapped in the gel layer, immune components in blood cannot be in direct contact with the allogeneic therapeutic cells, so that the immunologic rejection of a human body can be reduced, the blood of the human body is filtered through the blood tube bundle, nutrient substances and oxygen are separated out from the blood tube bundle to supply the allogeneic therapeutic cells for normal metabolism, the allogeneic therapeutic cells generate therapeutic factors, and the therapeutic factors flow into a patient body along with the blood to achieve the purpose of treating diseases.
According to some embodiments of the invention, the blood tube bundle comprises a plurality of blood tubes, and the blood tubes are respectively fixed on two ends of the blood tubes.
According to some embodiments of the present invention, the mounting plate includes two opposite mounting portions, a gap is formed between the two mounting portions, each mounting portion has a plurality of mounting openings arranged at intervals, the mounting openings of the two mounting portions are in one-to-one correspondence and are arranged in opposite directions, two sides of each blood tube bundle are respectively inserted into the two mounting openings, a reaction cavity is formed by the adjacent blood tube bundles and the mounting portions, and the hydrogel is filled in the reaction cavity.
According to some embodiments of the invention, the mounting plates have mounting holes, the ends of the blood tube bundle are inserted into the mounting holes, the two mounting plates divide the accommodating chamber into a first buffer chamber, a blood flow chamber and a second buffer chamber, the blood flow chamber is located between the two mounting plates, the blood inlet is communicated with the first buffer chamber, and the blood outlet is communicated with the second buffer chamber.
According to some embodiments of the invention, the blood tube bundle comprises a plurality of blood flow tubes, the plurality of blood flow tubes are arranged side by side and form the blood tube bundle, two ends of the blood tube bundle are provided with sealing parts, the sealing parts are inserted into the mounting holes, and the blood flow tubes are fixedly connected at the sealing parts.
According to some embodiments of the invention, the housing comprises at least one baffle, the baffle being located between two of the mounting plates, an edge of the baffle being connected to an inner wall of the housing, the baffle dividing the blood flow chamber into a plurality of perfusion units, the baffle having through holes through which the blood tube bundle passes.
According to some embodiments of the invention, the housing comprises a filling opening, the filling opening is communicated with the blood flow cavity, and a valve for opening and closing the filling opening is arranged at the filling opening.
According to some embodiments of the invention, the housing comprises a first shell and a second shell, the first shell and the second shell are movably connected to close or open the accommodating cavity.
According to some embodiments of the invention, the housing further comprises a plurality of filter screens, the filter screens are accommodated in the second buffer cavity, and edges of the filter screens are connected to the inner wall of the housing.
According to some embodiments of the invention, the housing further comprises two flushing ports, the two flushing ports being in communication with the first buffer chamber and the second buffer chamber, respectively.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Drawings
The invention is further described with reference to the following figures and examples, in which:
FIG. 1 is a schematic structural view of an embodiment of a multifunctional artificial visceral organ apparatus according to the invention;
FIG. 2 is a schematic view of the mating of one embodiment of a blood tube bundle and a housing;
FIG. 3 is a schematic view of the mating of one embodiment of a blood tube bundle and mounting plate;
FIG. 4 is a cross-sectional view of one embodiment of a hydrogel of the invention;
FIG. 5 is a cross-sectional view of one embodiment of the housing of FIG. 1;
FIG. 6 is a schematic view of one embodiment of a mounting plate of the present invention;
FIG. 7 is a schematic structural view of one embodiment of a blood tube bundle of the present invention;
FIG. 8 is a cross-sectional view of the blood tube bundle of FIG. 7;
fig. 9 is a side view of the multifunctional artificial organ device of fig. 1.
Reference numerals:
the blood perfusion apparatus comprises a shell 100, an accommodating cavity 110, a blood inlet 120, a blood outlet 130, a mounting plate 140, a mounting hole 141, a mounting part 142, a mounting opening 1421, a reaction cavity 150, a first buffer cavity 160, a blood flow cavity 170, a perfusion unit 171, a second buffer cavity 180, a partition plate 190, a perfusion opening 101, a first shell 102, a second shell 103, a flushing opening 104 and a shell 105; a blood tube bundle 200, a blood flow tube 210, a sealing part 220; hydrogel 300, gel layer 310, allogeneic therapeutic cells 320.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.
In the description of the present invention, it should be understood that the orientation or positional relationship referred to in the description of the orientation, such as the upper, lower, front, rear, left, right, etc., is based on the orientation or positional relationship shown in the drawings, and is only for convenience of description and simplification of description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.
In the description of the present invention, the meaning of a plurality is one or more, the meaning of a plurality is two or more, and the above, below, exceeding, etc. are understood as excluding the present numbers, and the above, below, within, etc. are understood as including the present numbers. If the first and second are described for the purpose of distinguishing technical features, they are not to be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated or implicitly indicating the precedence of the technical features indicated.
In the description of the present invention, unless otherwise specifically limited, terms such as set, installation, connection and the like should be understood in a broad sense, and those skilled in the art can reasonably determine the specific meanings of the above terms in the present invention by combining the specific contents of the technical solutions.
In the description of the present invention, reference to the description of "one embodiment", "some embodiments", "illustrative embodiments", "examples", "specific examples", or "some examples", etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
Referring to fig. 1 to 3, an embodiment of the present invention provides a multifunctional artificial organ device, including a shell 100, a blood tube bundle 200 and a hydrogel 300, wherein the shell 100 is internally provided with a receiving cavity 110, a blood inlet 120 and a blood outlet 130 are formed in a side portion of the shell 100, the blood inlet 120 and the blood outlet 130 are both communicated with the receiving cavity 110, and the blood inlet 120 and the blood outlet 130 are both connected with an artificial blood vessel through a quick connector and then connected with a blood vessel of a human body; a plurality of blood tube bundles 200 are arranged, the blood tube bundles 200 are accommodated in the accommodating cavity 110, one end of each blood tube bundle 200 is communicated with the blood inlet 120, the other end of each blood tube bundle 200 is communicated with the blood outlet 130, human blood enters the blood tube bundles 200 from the blood inlet 120, the blood flows through the blood tube bundles 200 and flows out of the accommodating cavity 110 from the blood outlet 130, the blood flowing out of the accommodating cavity 110 reenters the human body, and the blood can circularly flow between the human body and a multifunctional artificial organ device; the hydrogel 300 is filled in the accommodating cavity 110, as shown in fig. 4, the hydrogel 300 includes a gel layer 310 and allogeneic therapeutic cells 320, the allogeneic therapeutic cells 320 are wrapped inside the gel layer 310, the allogeneic therapeutic cells 320 are stimulated by substances precipitated from the blood of the human body to secrete corresponding therapeutic factors, which may be hormones or other secretions, and due to the characteristics of hydrophilicity and macroporosity of the hydrogel 300, the requirements of exchanging nutrient substances between the allogeneic therapeutic cells 320 and the blood and discharging waste can be met.
When human blood flows through the blood tube bundle 200, substances such as nutrient substances, oxygen and the like are separated out from the blood tube bundle 200, the substances are used for maintaining the metabolism of the allogeneic therapeutic cells 320 and maintaining the activity, the gel layer 310 of the hydrogel 300 has higher porosity and smaller pore size, the immune components in the human blood can be effectively prevented from entering, the immune components in the blood cannot be in direct contact with the allogeneic therapeutic cells, the rejection between the human blood and the allogeneic therapeutic cells 320 is reduced, the substances can stimulate the allogeneic therapeutic cells 320 to secrete therapeutic factors outwards, the therapeutic factors have the effect of treating internal organs, the therapeutic factors enter the blood tube bundle 200, are mixed with the blood and are discharged out of the shell 100 together with the blood, and when the therapeutic factors flow to the corresponding internal organs along with the blood, the purpose of treating diseases is achieved.
Therefore, in the multifunctional artificial viscera device in the embodiment of the invention, the allogeneic therapeutic cells 320 are wrapped inside the gel layer 310 to reduce the immunologic rejection of the human body, and the blood of the human body is filtered through the blood tube bundle 200, so that the blood tube bundle 200 can separate out nutrient substances and oxygen for the allogeneic therapeutic cells 320 to metabolize normally, and the allogeneic therapeutic cells 320 can generate therapeutic factors for treating the viscera, and the therapeutic factors can flow to the viscera along with the blood to achieve the purpose of treating diseases.
The multifunctional artificial organ device of the present invention can be applied to diseases caused by organ damage or cell function loss. Under the condition that the function of the original organ of the patient is not completely disabled or completely disabled, the therapeutic factors secreted by the allogeneic therapeutic cells 320 of the transplanted multifunctional artificial visceral organ device can flow along with the blood of the human body, the therapeutic factors can treat diseases to make up for the functional deficiency or the cell functional deficiency of the original organ, so that the multifunctional artificial visceral organ device has the basic functions of the original organ of the human body, and the therapeutic factors secreted by the cells in the device make up for the functional deficiency of the organ of the patient to maintain the normal metabolism of the human body.
In addition, the multifunctional artificial visceral organ device has a small volume and can be transplanted into a human body, such as an iliac fossa and a splenic fossa of the human body, and the blood inlet 120 and the blood outlet 130 of the multifunctional artificial visceral organ device can be directly connected with an artificial blood vessel from the inside of the human body through connectors and then are connected with the blood vessel of the human body, so that the multifunctional artificial visceral organ device is not polluted by the external environment.
The allogeneic therapeutic cells 320 may be one or more of liver cells, kidney cells and islet cells, for example, the allogeneic therapeutic cells 320 are islet cells, the islet cells absorb oxygen and nutrients separated out by the blood tube bundle 200 to metabolize, and secrete insulin, the insulin enters the blood tube bundle 200 and flows along with blood, and the insulin promotes glucose metabolism in the blood to reduce blood sugar of the patient, so that the effect of treating diabetes is achieved. It should be noted that if the allogeneic therapeutic cells 320 are configured as islet cells and hepatocyte cells, diabetes, liver disease and kidney disease can be treated through the similar process, and thus, a multifunctional artificial organ device can be widely applied to the biomedical field.
Specifically, when used for liver disease treatment, the hydrogel 300 has a size of 50-600 μm, the allogeneic therapeutic cells 320 are hepatocytes, and the allogeneic therapeutic cells 320 are distributed in the gel layer 310 at about 800-1500 cells/100 μm; when used in the treatment of diabetes, the allogeneic therapeutic cells are islet cells, about 1IEQ/100-600 μm; when used in the treatment of renal disease, it should be a shear-thinning or flowing hydrogel. The hydrogel 300 may be macroscopic hydrogel or microgel, the material of the hydrogel 300 may be one or more of natural polysaccharides, such as cellulose and its derivatives, gelatin, collagen, alginic acid, hyaluronic acid, chitosan and its derivatives, chondroitin sulfate, etc., and the material of the hydrogel 300 may also be one or more of synthetic polymers, such as polyethylene glycol, polyvinyl alcohol, poly (2-hydroxyethyl methacrylate), poly (N-isopropylacrylamide), guanidine polymers, etc.
The quick connector is a luer connector and the like, the quick connector is connected with an artificial blood vessel, the artificial blood vessel can be Polytetrafluoroethylene (PTFE), polyurethane (PU) or a 3D printed blood vessel and the like, the artificial blood vessel is matched with a human body blood vessel, if a multifunctional artificial organ device is transplanted in a human body iliac fossa, the blood inlet 120 is connected with an iliac artery, the blood outlet 130 is connected with an iliac vein, and after the artificial blood vessel is connected with the human body blood vessel, the blood can circularly flow between the multifunctional artificial organ device and the human body through the quick connector.
As shown in fig. 5, the housing 100 further includes two mounting plates 140, the mounting plates 140 are received in the receiving cavity 110, edges of the mounting plates 140 are connected to an inner wall of the housing 100, so as to divide the receiving cavity 110 of the housing 100 into a first buffer cavity 160, a blood flow cavity 170 and a second buffer cavity 180, and the blood flow cavity 170 is located between the two mounting plates 140.
The blood tube bundle 200 can be a blood fiber tube or a planar membrane, the fiber tube is made of one of Polytetrafluoroethylene (PTFE), polyurethane (PU), polyethylene terephthalate (PET) and other polymers, and is prepared by an electrostatic spinning method, a biaxial stretching method, a phase separation method, a particle-induced pore-forming method and the like, and in order to avoid the blood coagulation phenomenon in the blood flowing process, the surface of the fiber tube can be subjected to anticoagulation treatment, such as physical coating, chemical deposition, chemical grafting and the like.
Further, when the blood tube bundle 200 is installed in the housing 100, referring to fig. 6, the mounting plate 140 has mounting holes 141, both ends of the blood tube bundle 200 are respectively inserted into the mounting holes 141 of the two mounting plates 140, the blood inlet 120 is communicated with the first buffer chamber 160, and the blood outlet 130 is communicated with the second buffer chamber 180. Blood entering the shell 100 from the outside firstly enters the first buffer cavity 160, and the blood is blocked by the mounting plate 140 and buffered in the first buffer cavity 160 so as to reduce the impact of the blood pressure on other components such as the blood tube bundle 200; in addition, the first buffer cavity 160 and the second buffer cavity 180 are both located at the end of the housing 100, and the blood inlet 120 and the blood outlet 130 can be interchanged, so that the convenience of the multifunctional artificial organ device is improved.
Referring to fig. 7 and 8, the blood tube bundle 200 includes a plurality of blood flow tubes 210, a plurality of blood flow tubes 220 are arranged side by side to form the blood tube bundle 200, and each of the blood flow tubes 210 is used for flowing blood. Because the diameter of the blood flow tube 210 is small, usually 0.1-75 μm, and the film thickness is 120-150 μm, the blood flow tube 210 has a large difficulty in assembling the mounting hole 141, and when the number of the blood tube bundles 200 is large, the assembling efficiency of the multifunctional artificial organ device is greatly limited, the cross-sectional size of the blood tube bundle 200 is large, and the size of the mounting hole 141 can be adjusted accordingly, so that the processing of the mounting hole 141 and the insertion of the blood tube bundle 200 into the mounting hole 141 are facilitated.
It should be noted that each blood tube bundle 200 includes a plurality of blood flow tubes 210, and the diameter of each blood flow tube 210 can be the same or different, and can be controlled by adjusting the number of blood flow tubes 210; further, the mounting plate 140 may be provided with a plurality of mounting holes 141, and in order to facilitate more uniform distribution of the hydrogel, the mounting holes 141 may have the same or different diameters.
The blood flow tube 210 may be a fiber tube or a flat membrane having a nano-pore, which is made of one of high polymers such as Polytetrafluoroethylene (PTFE), polyurethane (PU), polyethylene terephthalate (PET), and polyvinyl alcohol (PVA), and is prepared by a commercially available method, an electrostatic spinning method, a biaxial stretching method, a particle-induced pore method, a phase separation method, or titanium dioxide (TiO) 2 ) Gold oxide (Au) 2 O 3 ) Alumina (Al) 2 O 3 ) The inorganic nano-film is prepared by a commercially available anodic oxidation method, a laser processing method, a micro-arc oxidation method and the like, and can perform anticoagulation treatment on the surface of the blood tube bundle to avoid the blood from caking phenomenon, such as physical coating, chemical deposition, chemical grafting and the like.
In order to further improve the convenience of inserting the blood tube bundle 200 into the mounting hole 141, in the embodiment of the present invention, the sealing portions 220 are disposed at two ends of the blood tube bundle 200, and the blood tube 210 is fixedly connected to the sealing portions 220, so as to prevent the blood tube 210 in the blood tube bundle 200 from being scattered, and facilitate the insertion of the tube bundle 400 into the mounting hole 141. In one embodiment, the two ends of the blood tube bundle 200 are sealed by a curing agent to form a sealing portion 220, and the plurality of blood tube bundles 200 are fixedly connected to the sealing portion 220 into a whole under the bonding action of the curing agent, wherein the curing agent may be made of silicon-based organic polymer Polymethylsiloxane (PDMS) or Polyurethane (PU) material or other curing agents.
When the mounting holes 141 are provided in plural numbers, the number of the mounting holes 141 is the same for the two mounting plates 140, so that both ends of each blood tube bundle 200 can be fixed. In one embodiment, the mounting holes 141 are distributed equally across the two mounting plates 140, and the blood tube bundle 200 is provided in multiple, side-by-side, positions. The hydrogel 300 is separated by the blood tube bundles 200 arranged side by side in the direction perpendicular to the extension direction of the blood tube bundles, so that the aggregation of the hydrogel 300 can be reduced, the hydrogel 300 in the blood flow cavity 170 is distributed more uniformly, and the matter exchange between the allogeneic therapeutic cells 320 and the blood in the blood tube bundles 200 is more sufficient.
In another embodiment, a plurality of the mounting holes 141 and the blood tube bundles 200 are provided, and the blood tube bundles 200 are distributed in a staggered manner; the interdigitated blood tube bundles 200 separate the hydrogel 300 from different regions of the blood flow lumen 170 to reduce aggregation of the hydrogel 300 and allow for adequate material exchange of the allogeneic therapeutic cells 320 with the blood within the blood tube bundles 200.
In one embodiment, the blood tube bundle 200 can be selected from a polymer film such as PTFE, PU, PVA, etc., or TiO 2 、Al 2 O 3 、Au 2 O 3 And the surface of the planar membrane can be subjected to anticoagulation treatment, such as physical coating, chemical deposition, chemical grafting and the like, in order to avoid the blood agglomeration phenomenon. When the blood tube bundle 200 is installed in the housing 100 in the form of a flat film, as shown in fig. 3, the installation plate 140 includes two installation parts 142 oppositely arranged with a gap between the two installation parts 142, each installation partThe installing parts 142 are provided with a plurality of installing openings 1421 arranged at intervals, the installing openings 1421 of the two installing parts 142 are in one-to-one correspondence and arranged oppositely, two installing openings 1421 are respectively inserted into two sides of each blood tube bundle 200, a reaction cavity 150 is formed by enclosing between the adjacent blood tube bundles 200 and the installing parts 142, and the hydrogel 300 is filled in the reaction cavity 150.
It should be noted that in the above embodiment, the mounting opening 1421 of the mounting portion 142 forms a hole for mounting the blood tube bundle 200, and the end of the blood tube bundle 200 can pass through the mounting plate 140 to communicate with the first buffer chamber 160 and the second buffer chamber 180. In addition, the size of the planar membrane is larger than that of the blood fiber tube, so that the planar membrane can be conveniently connected to the mounting opening 1421, and since the adjacent reaction chambers 150 are independent of each other, the hydrogel 300 is confined in each reaction chamber 150, so that the hydrogel 300 can be prevented from being accumulated in the housing 100.
Further, as shown in fig. 5, the casing 100 further includes at least one partition 190, the partition 190 is located between two mounting plates, an edge of the partition 190 is connected to an inner wall of the casing 100, the partition 190 partitions the blood flow chamber 170 into a plurality of perfusion units 171, the partition 190 has a through hole, and the blood tube bundle 200 is inserted into the through hole. The partition 190 partitions the hydrogel 300 along the extending direction of the blood tube bundle 200, so that the hydrogel 300 is uniformly distributed in different perfusion units 171, thereby further improving the uniformity of distribution of the hydrogel 300 in the blood flow cavity 170; through the interval distribution of different blood tube bundles 200 and the arrangement of the partition plate 190, the hydrogel 300 is partitioned in different directions, and the distribution uniformity of the hydrogel 300 in the blood flow cavity 170 is effectively improved.
In one embodiment, the housing 100 further includes a filling opening 101, the filling opening 101 is communicated with the blood flow chamber 170, and a valve for opening and closing the filling opening 101 is disposed at the filling opening 101. Before the multifunctional artificial organ device is used, hydrogel 300 is poured into a blood flow cavity 170 through a pouring port 101, the hydrogel 300 is uniformly distributed between adjacent blood tube bundles 200 and in each pouring unit 171, a valve is closed, the pouring port 101 is sealed, a shell 100 is in a closed state, and after the multifunctional artificial organ device is connected with an artificial blood vessel through a quick connector, disease treatment can be carried out; through setting up pouring opening 101, can directly pour into aquogel 300 in blood flow cavity 170, make aquogel 300 can evenly distributed in blood flow cavity 170, and pouring opening 101 can set up a plurality ofly according to the quantity of pouring unit 171, each pouring unit 171 all communicates with a pouring opening 101, aquogel 300 gets into each pouring unit 171 through pouring opening 101 in, can avoid the aquogel 300 after pouring to gather in certain region of blood flow cavity 170, guarantee the degree of consistency that aquogel 300 distributes in each pouring unit 171.
In addition, as shown in fig. 9, the housing 100 further includes a first housing 102 and a second housing 103, and the first housing 102 and the second housing 103 are movably connected and can be opened and closed with each other. For example, one side of the first housing 102 is hinged to one side of the second housing 103, the other side of the first housing 102 is clamped to the other side of the second housing 103, when the first housing 102 is clamped to the second housing 103, the first housing 102 and the second housing 103 are buckled to form the closed housing 100, the accommodating cavity 110 inside the housing 100 is closed, when the first housing 102 and the second housing 103 are released from clamping, the first housing 102 and the second housing 103 rotate relative to each other and are opened based on the hinged position, and the housing 100 is opened. The first housing 102 and the second housing 103 are configured in an openable and closable structure to facilitate pouring of the hydrogel 300 into the interior of the housing 100. The first housing 102 and the second housing 103 are positioned between the two mounting plates 150, and a gap therebetween forms the blood flow chamber 170, so that when perfusion is performed, the blood flow chamber 170 can be opened only by opening and closing the first housing 102 and the second housing 103, and the hydrogel 300 can be perfused or replaced into the blood flow chamber 170, thereby keeping the first buffer chamber 160 and the second buffer chamber 180 sealed.
It should be noted that, because the blood tube bundle 200 and the hydrogel 300 in the present invention are independent from each other, and the blood tube bundle 200 is fixed by the two mounting plates 140 and the partition plate 190, when performing hydrogel perfusion and hydrogel replacement, the blood tube bundle 200 is less affected, which facilitates the replacement of the hydrogel 300 and the cleaning and recycling of a multifunctional artificial organ device, and the hydrogel 300 in one or more perfusion units 171 can be replaced selectively according to the requirement of the multifunctional artificial organ device.
The first housing 102 and the second housing 103 may be provided in a symmetrical structure with each other, or in an asymmetrical structure. In one embodiment, the first housing 102 and the second housing 103 are asymmetric, the abutting position of the first housing 102 and the second housing 103 is 1/3-1/4 of the edge of the housing 100, the volume of the inner space of the second housing 103 is greater than the volume of the inner space of the first housing 102, the edges of the mounting plate 140 and the partition plate 190 are fixedly connected to the inner wall of the second housing 103, the second housing 103 has a higher capability of containing the hydrogel 300 than the first housing 102, the hydrogel 300 can be directly poured into the second housing 103, and after the first housing 102 and the second housing 103 are closed, the edges of the mounting plate 140, the mounting plate 150 and the partition plate 190 and the inner wall of the first housing 102 abut against each other, so that the first buffer cavity 160, the second buffer cavity 180 and the blood flow cavity 170 are independent from each other.
In addition, since the blood inlet 120 and the blood outlet 130 are provided in the first housing 102 or the second housing 103, the blood inlet 120 or the blood outlet 130 can be more easily sealed by providing the blood inlet 120 and the blood outlet 130 separately in the first housing 102 or the second housing 103 than by forming the blood inlet 120 or the blood outlet 130 by combining the first housing 102 and the second housing 103 after they are closed.
Still be provided with on first shell 102 or the second shell 103 and wash mouthful 104, it is provided with two to wash mouthful 104, two wash mouthful 104 and communicate respectively to first cushion chamber 160 and second cushion chamber 180, it can the connecting tube to wash mouthful 104 department, the blood that lets in first cushion chamber 160 or second cushion chamber 180 has the coagulation risk, wash into buffer solutions such as normal saline through washing mouthful 104 to first cushion chamber 160 or second cushion chamber 180, wash out the blood clot from a multi-functional artificial internal organs device, avoid blood to block up the flow channel of blood, influence the flow efficiency of blood.
The housing 100 further has a filter screen 105, the filter screen 105 is accommodated in the second buffer chamber 180, an edge of the filter screen 105 is connected to an inner wall of the housing 100, and the filter screen 105 filters blood flowing out of the housing 105 to prevent blood clots from flowing to a human body. The filter screen 105 is provided with a plurality of layers, and the filter screens 105 in different layers have different apertures so as to intercept blood clots with different sizes; along the direction of blood export 130, the aperture of filter screen 105 reduces in proper order, through the mode of multistage filtration, makes the less blood clot deposit in the filter screen 105 of lowest department, avoids the blood clot to accumulate on same filter screen 105.
Multifunctional artificial viscera device still includes pressure sensor, pressure sensor can set up in first cushion chamber 160, in second cushion chamber 180 or blood flow chamber 170, pressure sensor detects the inside pressure of casing 100, and through the bluetooth, mode such as infrared will detect data transfer to external system module, so that system module acquires the internal pressure of casing 100 current status, and take corresponding measure, avoid appearing because the pressure is too high, lead to the casing to break, or because casing 100 reveals, lead to the condition that casing 100 internal pressure is low excessively, pressure sensor can select to be ceramic material, semiconductor material or organic material make.
In addition, the multifunctional artificial viscera device also comprises a blood parameter sensor which is arranged in the shell 100 and used for detecting the content of different elements in blood and transmitting data to the extracorporeal system module in the modes of Bluetooth, infrared and the like. For example, when the allogeneic therapeutic cells 320 are islet cells, the blood parameter sensor detects the blood sugar content to obtain the therapeutic effect of the allogeneic therapeutic cells 320, so as to achieve the purpose of acquiring the working state of the multifunctional artificial organ device in real time.
In addition, multi-functional artificial viscera device still includes the bubble sensor, and the bubble sensor sets up in casing 100 for detect the bubble content in the blood, and through modes such as bluetooth, infrared with data transfer to external system module, so that the system module acquires the bubble condition of casing 100 current state, and in time take corresponding measure, avoid appearing because the bubble leads to a large amount of blood coagulation conditions, the bubble sensor can select to make for ceramic material, semiconductor material or organic material.
The embodiments of the present invention have been described in detail with reference to the drawings, but the present invention is not limited to the embodiments, and various changes can be made within the knowledge of those skilled in the art without departing from the gist of the present invention. Furthermore, the embodiments of the present invention and the features of the embodiments may be combined with each other without conflict.

Claims (10)

1. A multifunctional artificial organ device, comprising:
the blood collection device comprises a shell, a blood collection device and a control device, wherein a containing cavity is arranged inside the shell, the shell is provided with a blood inlet and a blood outlet, and the blood inlet and the blood outlet are communicated with the containing cavity;
the blood tube bundles are accommodated in the accommodating cavity, one end of each blood tube bundle is communicated with the blood inlet, and the other end of each blood tube bundle is communicated with the blood outlet;
hydrogel, fill in hold the intracavity, hydrogel includes gel layer and xenogenesis treatment cell, xenogenesis treatment cell parcel in the inside of gel layer, xenogenesis treatment cell absorbs follow the material of blood tube bank separation out and to hold the chamber secretion treatment factor.
2. The multifunctional artificial visceral organ device according to claim 1, further comprising two mounting plates, wherein the mounting plates are disposed in the housing, the mounting plates are connected to an inner wall of the housing, and both ends of the blood tube bundle are fixed to the two mounting plates, respectively.
3. The multifunctional artificial visceral organ device according to claim 2, wherein the mounting plate comprises two oppositely disposed mounting portions, a gap is formed between the two mounting portions, each mounting portion has a plurality of mounting openings disposed at intervals, the mounting openings of the two mounting portions correspond to each other in a one-to-one manner and are disposed oppositely, two mounting openings are respectively inserted into two sides of each blood tube bundle, a reaction cavity is formed between the adjacent blood tube bundles and the mounting portions in a surrounding manner, and the hydrogel is filled in the reaction cavity.
4. The multifunctional artificial visceral organ device according to claim 2, wherein the mounting plate has mounting holes, ends of the blood tube bundles are inserted into the mounting holes, the two mounting plates divide the accommodating chamber into a first buffer chamber, a blood flow chamber and a second buffer chamber, the blood flow chamber is located between the two mounting plates, the blood inlet is communicated with the first buffer chamber, and the blood outlet is communicated with the second buffer chamber.
5. The multifunctional artificial visceral organ device according to claim 4, wherein the blood tube bundle comprises a plurality of blood flow tubes, the plurality of blood flow tubes are arranged side by side and form the blood tube bundle, sealing parts are arranged at two ends of the blood tube bundle, the sealing parts are inserted into the mounting holes, and the blood flow tubes are fixedly connected at the sealing parts.
6. A multifunctional artificial visceral organ device according to claim 4 or 5, wherein the housing comprises at least one partition plate, the partition plate is located between the two mounting plates, the edge of the partition plate is connected with the inner wall of the housing, the partition plate divides the blood flow cavity into a plurality of perfusion units, the partition plate is provided with through holes, and the blood tube bundle is arranged through the through holes.
7. The multifunctional artificial visceral organ device according to claim 4, wherein the housing comprises an infusion port, the infusion port is communicated with the blood flow cavity, and a valve for opening and closing the infusion port is arranged at the infusion port.
8. The multifunctional artificial visceral organ device of claim 1, wherein the housing comprises a first housing and a second housing, and the first housing and the second housing are movably connected to close or open the accommodating cavity.
9. The multifunctional artificial visceral organ device of claim 4, wherein the housing further comprises a plurality of filter screens, the filter screens are accommodated in the second buffer cavity, and edges of the filter screens are connected to the inner wall of the housing.
10. The multi-functional artificial organ device according to claim 9, wherein the housing further comprises two flushing ports, and the two flushing ports are respectively communicated with the first buffer chamber and the second buffer chamber.
CN202210726199.0A 2022-06-24 2022-06-24 Multifunctional artificial organ device Pending CN115137899A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210726199.0A CN115137899A (en) 2022-06-24 2022-06-24 Multifunctional artificial organ device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210726199.0A CN115137899A (en) 2022-06-24 2022-06-24 Multifunctional artificial organ device

Publications (1)

Publication Number Publication Date
CN115137899A true CN115137899A (en) 2022-10-04

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN202210726199.0A Pending CN115137899A (en) 2022-06-24 2022-06-24 Multifunctional artificial organ device

Country Status (1)

Country Link
CN (1) CN115137899A (en)

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