CN115068561A

CN115068561A - Traditional Chinese medicine composition for treating atopic dermatitis and application thereof

Info

Publication number: CN115068561A
Application number: CN202210802698.3A
Authority: CN
Inventors: 苗晋鑫; 宋韶鹤
Original assignee: Henan University of Traditional Chinese Medicine HUTCM
Current assignee: Henan University of Traditional Chinese Medicine HUTCM
Priority date: 2022-07-07
Filing date: 2022-07-07
Publication date: 2022-09-20

Abstract

The invention provides a traditional Chinese medicine composition for treating atopic dermatitis and application, and relates to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition has the effects of clearing heat and removing toxicity, dispelling wind and removing dampness, relieving itching and killing insects, can realize higher cure rate of atopic dermatitis, reduce the recurrence of diseases, shorten the treatment period, obviously reduce inflammatory factors, play a role in treatment fundamentally and greatly relieve the pain of patients.

Description

Traditional Chinese medicine composition for treating atopic dermatitis and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating atopic dermatitis and application thereof.

Background

Atopic Dermatitis (AD) is a chronic, recurrent, inflammatory skin disease that is clinically manifested as a rash with severe itching on the face, extremities, eyelids, hand, instep, etc. According to survey, the prevalence rate of the disease in children is 15-30% globally, the prevalence rate of adults is 2-10%, and the prevalence rate of AD is gradually increased year by year along with the increase of environmental pollution and mental stress. AD patients are at increasing risk for infections, lymphomas and non-melanoma skin cancers, which severely affect the quality of life of the patients. Modern medical research considers that AD is closely related to factors such as skin barrier dysfunction, immune abnormality, skin flora disorder, familial inheritance and the like, but specific action mechanisms are still unclear. The traditional Chinese medicine considers that AD is caused by the combination of internal and external pathogenic factors, the internal causes are caused by spleen and stomach deficiency heat, spleen and lung qi deficiency, heart fire hyperactivity, external pathogenic wind, dampness and heat, the heat is transformed into heat after a long time, the damp heat is stagnated in skin and striae, and the treatment principles are spleen strengthening, dampness eliminating, heat clearing, blood cooling, blood circulation promoting, blood stasis removing, wind dispelling and itching relieving. At present, most of the western medicines including antihistamine, glucocorticoid and immunosuppressant are used in western medicine, and repeated use of the medicines can cause damage such as adrenal suppression, skin atrophy, thinning and pigment loss, and the diseases are easy to relapse and seriously affect the life of patients. The traditional Chinese medicine has long history, outstanding curative effect and small adverse reaction, and the traditional Chinese medicine has certain progress in treating AD (AD) along with the increase of the attention degree of the traditional Chinese medicine in the world in recent years, and a plurality of documents and patents disclose that related traditional Chinese medicine formula is used for treating atopic dermatitis, but has the defects of poor curative effect, easiness in repetition, long treatment period and the like.

Disclosure of Invention

Technical problem to be solved

Aiming at the defects of the prior art, the invention provides the traditional Chinese medicine composition for treating atopic dermatitis and the application thereof, the traditional Chinese medicine composition has the effects of clearing away heat and toxic materials, dispelling wind and removing dampness, relieving itching and killing parasites, and can achieve the technical effects of realizing higher cure rate of atopic dermatitis, reducing the recurrence of diseases, shortening the treatment period and greatly relieving the pain of patients.

(II) technical scheme

In order to achieve the purpose, the invention is realized by the following technical scheme:

on one hand, the invention provides a traditional Chinese medicine composition for treating atopic dermatitis, which comprises the following traditional Chinese medicine components in parts by weight: 20-40 parts of radix rehmanniae recen, 20-40 parts of gypsum, 5-15 parts of tree peony bark, 5-15 parts of red paeony root, 5-15 parts of common anemarrhena rhizome, 5-15 parts of honeysuckle flower, 5-15 parts of weeping forsythia capsule, 5-15 parts of common lophatherum herb, 10-25 parts of wild grass incense, 20-40 parts of densefruit pittany root-bark, 10-30 parts of stir-fried tribulus terrestris, 5-15 parts of prepared fleece-flower root, 5-25 parts of szechuan lovage rhizome and 1-10 parts of raw liquoric root.

Further, the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight: 25-35 parts of radix rehmanniae recen, 25-35 parts of gypsum, 7-12 parts of tree peony bark, 7-12 parts of red peony root, 7-12 parts of rhizoma anemarrhenae, 7-12 parts of honeysuckle, 7-12 parts of fructus forsythiae, 7-12 parts of lophatherum gracile, 15-20 parts of wild grass incense, 25-35 parts of cortex dictamni, 15-20 parts of stir-fried caltrop, 8-12 parts of prepared fleece-flower root, 10-20 parts of ligusticum chuanxiong hort and 4-8 parts of raw liquorice.

Further, the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight: 30 parts of radix rehmanniae recen, 30 parts of gypsum, 9 parts of tree peony bark, 9 parts of red peony root, 9 parts of rhizoma anemarrhenae, 9 parts of honeysuckle, 9 parts of fructus forsythiae, 9 parts of lophatherum gracile, 15 parts of wild herb incense, 30 parts of cortex dictamni, 20 parts of stir-fried caltrop, 10 parts of prepared fleece-flower root, 15 parts of ligusticum chuanxiong hort and 6 parts of raw liquorice.

Further, the traditional Chinese medicine composition is prepared into an oral medicine suitable for medical use according to a conventional traditional Chinese medicine preparation method, preferably a water decoction, and is taken once each day in the morning and at night after meals.

On the other hand, the invention also provides application of the traditional Chinese medicine composition for treating the atopic dermatitis in preparing a medicine for treating the atopic dermatitis.

The pharmacological actions of the traditional Chinese medicine components in the traditional Chinese medicine composition are as follows:

dried rehmannia root: cold in nature, bitter and sweet in taste; heart, liver and kidney meridians entered; has effects in clearing away heat, cooling blood, nourishing yin, and promoting fluid production, and can be used for treating fever, crimson tongue, polydipsia, yin deficiency, internal heat, bone steaming, senile heat, diabetes, hematemesis, speckle, and erythra; it mainly contains iridoid, ionone, phenethyl alcohol compound, triterpenes, flavonoids, lignan grin, phenolic acids and other compounds; modern pharmacological studies show that rehmannia has significant effects on a human blood system, a cardiovascular system, a cerebrovascular system, a central nervous system and an immune system, and also has the effects of regulating blood sugar and blood fat, resisting aging, resisting tumors, inhibiting bacteria, resisting gastric ulcer, protecting gastric mucosa and the like.

Raw gypsum: the gypsum plaster has the advantages of large and cold nature, sweet and pungent taste, has the effects of penetrating exterior and relieving muscles, has the efficacies of clearing heat and draining water, relieving restlessness and quenching thirst and the like, is one of the most common mineral traditional Chinese medicines, contains abundant trace elements such as zinc, copper, iron, manganese and the like, and has the effects of reducing fever, improving immunity, resisting virus and the like according to modern pharmacological research.

Moutan bark: bitter and pungent taste, slightly cold nature; heart, liver and kidney meridians entered; has the effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis; can be used for treating heat entering nutrient-blood, toxic heat, speckle, carbuncle, swelling, and sore; cortex moutan contains a large amount of complex chemical components such as phenol and phenol glycosides, monoterpene and its glycosides, triterpenes, etc.; modern pharmacological research shows that the tree peony bark has strong functions of bacteriostasis, anti-inflammation, anti-tumor, anti-arrhythmia, blood sugar reduction, activation of the immune system of the organism, protection of the cardiovascular system and the like,

Red peony root: slightly cold in nature and bitter in taste; entering liver and spleen meridians; has effects in clearing away heat, cooling blood, promoting blood circulation, and dispelling blood stasis; can be used for treating heat entering nutrient-blood, macula due to toxic heat, liver depression, hypochondriac pain, swelling, and pyocutaneous disease; the radix Paeoniae Rubra contains effective chemical components such as radix Paeoniae Rubra total glycosides, gallic acid, radix Paeoniae Rubra total flavonoids and neolignanoid glycosides; modern pharmacological studies show that the red paeony root has the effects of protecting nerves, resisting depression, regulating blood sugar and blood fat, resisting inflammation, inhibiting bacteria, resisting tumors, resisting oxidation, regulating immunity and the like.

Rhizoma anemarrhenae: bitter taste and cold nature, entering lung, stomach and kidney meridians; has the effects of clearing heat, purging fire, nourishing yin, moistening dryness, etc.; can be used for treating fever polydipsia, lung heat dry cough, hectic fever due to yin-deficiency, internal heat diabetes, and constipation due to intestinal dryness; the rhizoma anemarrhenae mainly contains active ingredients of saponins, bipyridone, lignin, alkaloid, polysaccharides, trace elements, a large amount of mucoid and the like, and has pharmacological effects of resisting inflammation and virus, inhibiting platelet aggregation, reducing blood sugar, reducing blood fat and the like.

Honeysuckle flower: sweet taste, cold nature, entering lung and stomach meridians; has effects in clearing away heat and toxic materials, relieving inflammation, and relieving swelling; can be used for treating various infectious diseases such as exogenous wind heat or epidemic febrile disease fever, heatstroke, toxic heat and bloody dysentery, carbuncle, furuncle, and pharyngitis; the honeysuckle flower mainly contains effective components such as flavonoid, organic acid, volatile oil, iridoid and the like; modern pharmacological studies show that the honeysuckle has the effects of resisting inflammation, resisting oxidation, resisting ultraviolet injury, reducing blood fat, reducing blood sugar, resisting virus and the like.

Fructus forsythiae: slightly cold in nature, bitter in taste, entering lung, heart and small intestine meridians; has effects of clearing away heat and toxic materials, relieving swelling, and dispersing pathogen accumulation; can be used for treating wind-heat type common cold, early stage epidemic febrile disease, warm heat entering nutrient system, hyperpyrexia, polydipsia, and heat stranguria; fructus forsythiae contains effective components such as phenethanol glycosides, lignans and their glycosides, pentacyclic triterpenes, phenolic acids, and volatile oil; modern pharmacological studies show that fructus forsythiae has the effects of resisting bacteria, viruses, inflammation and oxidation, relieving fever and pain, resisting tumors, resisting fatigue and the like.

Herba lophatheri: sweet and light taste, cold in nature, and entering heart, lung, stomach and bladder meridians; has the effects of clearing heat, purging fire, relieving restlessness, promoting urination, etc.; can be used for treating fever, polydipsia, aphtha, dark urine, stranguria caused by heat, and pain; the lophatherum gracile leaves contain flavonoid compounds, triterpenoid compounds, volatile components, phenolic acids, polysaccharides, amino acids and trace elements, and modern pharmacological studies show that the lophatherum gracile leaves have the effects of bacteriostasis, antioxidation, liver protection, blood vessel contraction, antivirus, blood fat reduction and myocardial protection.

Wild grass fragrance: has pungent and cool taste, has effects of removing toxic substance, clearing heat, relieving exterior syndrome, dispelling cold, etc., and can be used for treating common cold with fever, nasosinusitis, tonsillitis, osteodynia, furuncle, headache, neurodermatitis, etc.

And (3) preparing cortex dictamni: bitter taste and cold nature; spleen, stomach and bladder meridians entered; has effects in clearing away heat, eliminating dampness, dispelling pathogenic wind, and removing toxic substances, and can be used for treating damp-heat sore, yellow water dripping, eczema, rubella, scabies, and rheumatism; the cortex Dictamni Radicis mainly contains ketone, dictamnine, phellodendron ketone, Y-zanthoxylum alkaloid, skimmianine, isodictamnine, dictamnolide, beta-sitosterol and a small amount of volatile oil; modern pharmacological research shows that the cortex dictamni has various pharmacological activities of antibiosis, anti-inflammation, antianaphylaxis, anticancer, hemostasis, disinsection, antitumor, neuroprotection and the like.

Frying caltrops: pungent and bitter in flavor, slightly warm in nature, entering liver meridian; has effects in calming liver, relieving depression, promoting blood circulation, expelling pathogenic wind, improving eyesight, and relieving itching; can be used for treating headache, vertigo, distending pain in chest and hypochondrium, mammary block, mammary abscess, conjunctival congestion, nebula, rubella, and pruritus.

Radix polygoni multiflori preparata: sweet, bitter and astringent in taste, warm in nature, and entering liver, heart and kidney meridians; has effects in nourishing liver and kidney, nourishing blood and essence, blackening hair and beard, and strengthening muscle and bone; can be used for treating blood deficiency, sallow complexion, giddiness, tinnitus, premature gray hair, soreness of waist and knees, numbness of limbs, metrorrhagia, leukorrhagia, etc.; the radix Polygoni Multiflori Preparata contains polysaccharides, stilbene glycosides, flavonoids, anthraquinones, phospholipids, etc., and has effects in lowering blood sugar, resisting atherosclerosis, preventing alopecia, protecting nerve, repairing liver injury, and resisting cancer.

Ligusticum wallichii: pungent in flavor and warm in nature, entering liver, gallbladder and pericardium meridian; has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain, and can be used for treating menoxenia, amenorrhea, dysmenorrhea, pricking pain in chest and hypochondrium, traumatic injury, rheumatalgia, etc.; the rhizoma Ligustici Chuanxiong contains effective components such as ligustrazine, sodium ferulate, and rhizoma Ligustici Chuanxiong lactone, and has pharmacological effects of promoting blood circulation for removing blood stasis, tranquilizing, relieving pain, and inhibiting release of oxygen free radical.

Raw licorice root: sweet in taste, neutral in nature, and entering spleen, stomach and lung meridians; has the effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the medicines; can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, carbuncle, and skin ulcer; the radix Glycyrrhizae contains effective components such as total flavonoids, glycyrrhizic acid, glycyrrhetinic acid, triterpenes, and liquiritin, and has antioxidant, antiinflammatory, immunity regulating, antiulcer, toxic materials clearing away, anticancer, and hepatic fibrosis resisting effects.

(III) advantageous effects

The invention provides a traditional Chinese medicine composition for treating atopic dermatitis and application thereof. The traditional Chinese medicine composition mainly comprises fourteen traditional Chinese medicines of radix rehmanniae, gypsum, tree peony bark, red paeony root, common anemarrhena rhizome, honeysuckle flower, weeping forsythia, common lophatherum herb, wild grass fragrance, densefruit pittany root-bark, stir-fried caltrop, prepared fleece-flower root, szechwan lovage rhizome, raw liquoric root and the like. The traditional Chinese medicine composition is obtained by creative work based on classical traditional Chinese medicine formulas such as four-ingredient decoction, jade girl decoction, forsythia powder and the like, and the traditional Chinese medicine composition applies the dialectical implementation principle of traditional Chinese medicine, and the raw rehmannia root in the formula has the effects of clearing heat and cooling blood, nourishing yin and promoting the secretion of saliva; gypsum Fibrosum has effects of clearing heat, purging pathogenic fire, astringing, and promoting granulation; the two drugs are combined to be monarch drugs, and have the effects of clearing heat and cooling blood, promoting the production of body fluid to quench thirst, detoxifying and removing ecchymoses. The combination of the tree peony bark, the red paeony root, the common anemarrhena rhizome, the honeysuckle, the weeping forsythia and the common lophatherum herb as ministerial drugs and the root of rehmannia as an adjuvant drug which is the tree peony bark and the red paeony root as well as the three drugs added into blood components can achieve the effects of cooling blood, removing toxicity, promoting blood circulation and removing blood stasis. Rhizoma anemarrhenae is bitter and cold and can purge fire without dryness, is sweet and cold and can moisten yin without greasiness, and can enhance the heat-clearing and fire-purging effects of gypsum; the honeysuckle and the weeping forsythia are combined to gently clear and ascend, float and disperse, and double the effect of clearing heat and removing toxicity; the bamboo leaves are added to assist in expelling heat and clearing away the heart-fire and relieving restlessness. Cortex Dictamni Radicis, fructus Tribuli preparata, radix Polygoni Multiflori Preparata and rhizoma Ligustici Chuanxiong are used as adjuvant drugs, cortex Dictamni Radicis and rhizoma anemarrhenae can be used together for dispelling pathogenic wind, clearing heat and relieving itching, and radix rehmanniae and radix Paeoniae Rubra can be used together for nourishing blood, dispelling pathogenic wind and clearing heat; the prepared fleece flower root has the effects of nourishing liver and kidney, tonifying essence and blood, removing heat from the liver and calming the liver by the stir-fried caltrop, and the compatibility of the two medicines can be used for concurrent blood circulation, stasis removal and tonifying; chuan Xiong can activate blood and move qi, dispel wind and alleviate pain, and is combined with He shou Wu to promote the action of nourishing yin, nourishing blood and activating collaterals. Raw liquorice is taken as a conductant drug to moderate the drug property, the hundred drugs are harmonized, the monarch, the minister, the assistant and the conductant drugs supplement each other, and the treatment is carried out based on syndrome differentiation to jointly treat patients with atopic dermatitis. The traditional Chinese medicine composition has the effects of clearing heat and removing toxicity, dispelling wind and removing dampness, relieving itching and killing insects, can realize higher cure rate of atopic dermatitis, reduce the recurrence of diseases, shorten the treatment period, obviously reduce inflammatory factors, play a role in treatment fundamentally and greatly relieve the pain of patients.

Drawings

FIG. 1 is a pathological section of mouse skin tissue, in which FIG. 1A is a blank group; FIG. 1B is a model set; FIG. 1C is a low dose traditional Chinese medicine group; fig. 1D is a high dose traditional Chinese medicine.

FIG. 2 is a graph showing the change in serum inflammatory factor levels in each group of mice.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive step based on the embodiments of the present invention, are within the scope of protection of the present invention.

Example 1

A traditional Chinese medicine composition for treating atopic dermatitis is prepared by weighing the following raw materials in parts by weight: 20 parts of radix rehmanniae, 20 parts of gypsum, 5 parts of tree peony bark, 5 parts of red paeony root, 5 parts of common anemarrhena rhizome, 5 parts of honeysuckle flower, 5 parts of weeping forsythia capsule, 5 parts of common lophatherum herb, 10 parts of wild grass flavor, 20 parts of cortex dictamni, 10 parts of stir-fried caltrop, 5 parts of prepared fleece-flower root, 5 parts of szechuan lovage rhizome and 2 parts of raw liquoric root; is prepared into water decoction, and one dose is taken after meals every morning and evening.

Example 2

This example differs from example 1 in that:

the weight parts of the raw materials are as follows: 40 parts of radix rehmanniae recen, 40 parts of gypsum, 15 parts of tree peony bark, 15 parts of red peony root, 15 parts of rhizoma anemarrhenae, 15 parts of honeysuckle, 15 parts of forsythia, 15 parts of lophatherum gracile, 25 parts of wild grass incense, 40 parts of cortex dictamni, 30 parts of stir-fried caltrop, 15 parts of prepared fleece-flower root, 25 parts of ligusticum chuanxiong hort and 10 parts of raw liquorice

Example 3

This example differs from example 1 in that:

the weight parts of the raw materials are as follows: 25 parts of radix rehmanniae, 25 parts of gypsum, 7 parts of tree peony bark, 7 parts of red paeony root, 7 parts of common anemarrhena rhizome, 7 parts of honeysuckle flower, 7 parts of weeping forsythia capsule, 7 parts of common lophatherum herb, 15 parts of wild herb, 25 parts of cortex dictamni, 15 parts of stir-fried caltrop, 8 parts of prepared fleece-flower root, 10 parts of szechuan lovage rhizome and 4 parts of raw liquoric root.

Example 4

This example differs from example 1 in that:

the weight parts of the raw materials are as follows: 35 parts of radix rehmanniae recen, 35 parts of gypsum, 12 parts of moutan bark, 12 parts of red peony root, 12 parts of rhizoma anemarrhenae, 12 parts of honeysuckle, 12 parts of fructus forsythiae, 12 parts of lophatherum gracile, 20 parts of wild herb incense, 35 parts of cortex dictamni, 20 parts of stir-fried caltrop, 12 parts of prepared fleece-flower root, 20 parts of ligusticum chuanxiong hort and 8 parts of raw liquorice.

Example 5

This example differs from example 1 in that:

the weight parts of the raw materials are as follows: 30 parts of radix rehmanniae recen, 30 parts of gypsum, 9 parts of tree peony bark, 9 parts of red peony root, 9 parts of rhizoma anemarrhenae, 9 parts of honeysuckle, 9 parts of fructus forsythiae, 9 parts of lophatherum gracile, 15 parts of wild herb incense, 30 parts of cortex dictamni, 20 parts of stir-fried caltrop, 10 parts of prepared fleece-flower root, 15 parts of ligusticum chuanxiong hort and 6 parts of raw liquorice.

Test example 1

In order to further verify the effectiveness of the traditional Chinese medicine composition in treating atopic dermatitis, the following animal experiments are provided for illustration.

1 materials and methods

1.1 test animals and groups

Selecting 24 SPF-grade BALB/c mice, male mice, 6 weeks old mice and 18-22g of body mass, randomly dividing the mice into 4 groups, wherein each group comprises 6 mice, and the groups respectively comprise a blank group, a model group, a low-dose traditional Chinese medicine group and a high-dose traditional Chinese medicine group; wherein, the AD model is made from 18 mice of the model group, the low-dose traditional Chinese medicine and the high-dose traditional Chinese medicine, and the model making method adopts a DNCB external coating method to make the model (the concrete method refers to the establishment of a model of atopic dermatitis of BALB/c mice induced by sensitization of DNCB [ J ]. Chinese tropical medicine, 2013, 13 (12): 1439-.

1.2 herbs are dried and collected

The low-dose traditional Chinese medicine and the high-dose traditional Chinese medicine are administered to the decoction prepared in the example 5 for intragastric administration, wherein the low-dose traditional Chinese medicine is administered according to the body mass of 0.1mL/10g, and the high-dose traditional Chinese medicine is administered according to the body mass of 0.3mL/10 g; the model group and the blank group were gazed with 0.9% physiological saline. The administration is 1 time per day, and the administration is continuously performed by gavage for 3 weeks. After the last administration, the patient is sacrificed and the material is taken within 24h (local skin lesion and blood is taken after the eyeball is picked), the skin tissue is compared with pathological sections and is subjected to immunohistochemical staining, and the peripheral blood is taken and is subjected to enzyme linked immunosorbent assay (ELISA) to determine the content of IgE, IL-1 beta, IL-4 and IFN-gamma in the blood serum.

1.3 statistical analysis

Data analysis statistical tests were performed on all data using SPSS20.0 software One-way ANOVA with results expressed as mean ± standard deviation and as (P <0.05) significant differences.

2 results of

2.1 histopathological changes in skin lesions

As can be seen from the histopathological results of the skin lesions of the mice, the blank group showed no hyperplasia of squamous epithelium and normal dermis (as shown in fig. 1A); the model group showed hyperkeratosis of the epidermis, hyperhypertrophy of the spinous layer, marked proliferation of the squamous epithelium, and infiltration of multiple inflammatory cells in the dermal layer (as shown in fig. 1B); compared with the model group, the low-dose and high-dose traditional Chinese medicines have the advantages that the low-dose traditional Chinese medicine composition and high-dose traditional Chinese medicine group has reduced acanthosis, squamous hyperplasia and inflammatory cell infiltration or no inflammatory cell infiltration (as shown in figures 1C and 1D); the high dose traditional Chinese medicine group was similar to the blank control group.

2.2 serological index Change

The serological inflammation index of the mouse is changed after 3 weeks of intervention after administration, LSD test shows that the expression levels of IgE, IL-1 beta and IL-4 of the model group are obviously increased compared with the low and high dose traditional Chinese medicines and the blank group, and the difference analysis has statistical significance (P is less than 0.05); compared with the blank group, the difference of the traditional Chinese medicine group has no statistical significance. Compared with the blank group and the high-dose traditional Chinese medicine group, the IFN-gamma expression level in the serum of the model group is increased, and the difference has statistical significance; the model group and the low-dose traditional Chinese medicine group have no statistical significance (P >0.05), and the results are detailed in table 1 and figure 2.

TABLE 1 serum index Change in groups of mice: (

n＝6)

Note: the different lower case letters in the shoulder marks in the same column indicate significant difference (P <0.05), and the same letters without shoulder marks or labels indicate insignificant difference (P > 0.05).

3 conclusion

According to the test results, the traditional Chinese medicine composition can obviously improve the skin injury degree of a dermatitis mouse, and obviously reduce inflammatory cell infiltration and squamous epithelial hyperplasia; the high-dose traditional Chinese medicine composition can obviously reduce the content of inflammatory factors in the blood serum of a dermatitis mouse, and can restore the content of the inflammatory factors to a normal level, and the results can fully show that the traditional Chinese medicine composition has a good treatment effect on the aspect of treating atopic dermatitis.

Test example 2

Observation of clinical efficacy of atopic dermatitis

1 general data

150 patients are outpatients, all patients are diagnosed as atopic dermatitis by a doctor of a dermatologist of the hospital, the diagnosis standard refers to Chinese diagnosis and treatment guidelines for atopic dermatitis (2020 edition), development and evolution of the diagnosis standard of atopic dermatitis, and development and evaluation of the diagnosis standard of atopic dermatitis, and all patients are randomly divided into three groups.

Control group 1: 32 men, 20 women, 16-55 years old, average age (38.62 + -3.97);

control group 2: 29 men and 19 women, the age is 20-47 years, and the average age is (31.54 +/-5.03);

treatment groups: 30 men and 20 women, the age is 18-53 years, and the average age (36.52 +/-6.21);

the general data of three groups of patients are compared, and the difference is not statistically significant (P >0.05) and is comparable.

Inclusion criteria were: the diagnosis was confirmed to be allergic dermatitis, skin pruritus and relapse. Exclusion criteria: (1) patients with other complications and contraindications; (2) those who do not take the drug according to the regulations; (3) patients with infectious skin disease were excluded.

2 method

Control group 1: levocetirizine hydrochloride tablets (Chongqing Huabang pharmaceutical Co., Ltd., national drug standard H20040249) are adopted, and the specification is 5 mg/tablet. The use method comprises the following steps: orally administered 1 time/1 tablet/d. The treatment course of the patient is 2 weeks.

Control group 2: the traditional Chinese medicine decoction for invigorating spleen, nourishing blood and dispelling wind is used for treatment, and the formula comprises the following medicines: 30g of tribulus terrestris, 30g of prepared fleece-flower root, 30g of astragalus root, 20g of divaricate saposhnikovia root, 15g of largehead atractylodes rhizome, 15g of Chinese angelica and 10g of centipede are decocted with water, 1 dose is taken every day in the morning and at night for 2 times, and the treatment lasts for 2 weeks.

Treatment groups: the decoction prepared in example 5 was used twice daily for 2 weeks.

3 determination of therapeutic Effect

And (3) healing: the skin lesions subside and the symptoms disappear;

the effect is shown: the skin lesion is faded by 60-90%, and the symptoms are obviously improved;

improvement: the skin lesion is faded by 20-59%, and the symptoms are improved;

and (4) invalidation: the skin damage is reduced by less than or equal to 20 percent, and the symptoms are not improved.

4 results

TABLE 2 therapeutic results for atopic dermatitis in each group

Grouping	Number of examples	Recovery method	Show effect	Improvement of life	Invalidation	Total effective rate
							Control group 1	52	11	30	2	9	82.7％
Control group 2	48	7	22	5	14	70.8％
							Treatment group
	50	34	5	5	6	88.0％

According to the results of clinical efficacy observation of atopic dermatitis, the traditional Chinese medicine composition has a curative effect on the atopic dermatitis which is obviously superior to that of levocetirizine hydrochloride tablets and spleen-tonifying blood-nourishing wind-dispelling decoction, the curative rate can reach 68.0 percent, and the total effective rate can reach 88.0 percent. The traditional Chinese medicine composition has the effects of clearing heat and removing toxicity, dispelling wind and removing dampness, relieving itching and killing parasites, can realize higher cure rate of atopic dermatitis, reduce the recurrence of diseases, shorten the treatment period, play a role in treatment fundamentally and greatly relieve the pain of patients.

The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims

1. The traditional Chinese medicine composition for treating atopic dermatitis is characterized by comprising the following traditional Chinese medicine components in parts by weight: 20-40 parts of radix rehmanniae recen, 20-40 parts of gypsum, 5-15 parts of tree peony bark, 5-15 parts of red peony root, 5-15 parts of rhizoma anemarrhenae, 5-15 parts of honeysuckle, 5-15 parts of fructus forsythiae, 5-15 parts of lophatherum gracile, 10-25 parts of wild grass incense, 20-40 parts of cortex dictamni, 10-30 parts of stir-fried caltrop, 5-15 parts of prepared fleece-flower root, 5-25 parts of ligusticum chuanxiong hort and 1-10 parts of raw liquorice.

2. The traditional Chinese medicine composition for treating atopic dermatitis according to claim 1, which is characterized by comprising the following traditional Chinese medicine components in parts by weight: 25-35 parts of radix rehmanniae recen, 25-35 parts of gypsum, 7-12 parts of tree peony bark, 7-12 parts of red peony root, 7-12 parts of rhizoma anemarrhenae, 7-12 parts of honeysuckle, 7-12 parts of fructus forsythiae, 7-12 parts of lophatherum gracile, 15-20 parts of wild grass incense, 25-35 parts of cortex dictamni, 15-20 parts of stir-fried caltrop, 8-12 parts of prepared fleece-flower root, 10-20 parts of ligusticum chuanxiong hort and 4-8 parts of raw liquorice.

3. The traditional Chinese medicine composition for treating atopic dermatitis as claimed in claim 1, wherein the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight: 30 parts of radix rehmanniae recen, 30 parts of gypsum, 9 parts of tree peony bark, 9 parts of red peony root, 9 parts of rhizoma anemarrhenae, 9 parts of honeysuckle, 9 parts of fructus forsythiae, 9 parts of lophatherum gracile, 15 parts of wild herb incense, 30 parts of cortex dictamni, 20 parts of stir-fried caltrop, 10 parts of prepared fleece-flower root, 15 parts of ligusticum chuanxiong hort and 6 parts of raw liquorice.

4. The traditional Chinese medicine composition for treating atopic dermatitis as claimed in any one of claims 1 to 3, wherein the traditional Chinese medicine composition is prepared into an oral medicine suitable for pharmaceutical use according to a conventional traditional Chinese medicine preparation method.

5. The use of the Chinese medicinal composition for treating atopic dermatitis as claimed in any one of claims 1 to 3, wherein the Chinese medicinal composition is used in the preparation of a medicament for treating atopic dermatitis.